RAB1A

Summary

Gene Symbol: RAB1A
Description: RAB1A, member RAS oncogene family
Alias: RAB1, YPT1, ras-related protein Rab-1A, GTP binding protein Rab1a, RAB1, member RAS oncogene family, Rab GTPase YPT1 homolog, YPT1-related protein
Species: human
Products:     RAB1A

Top Publications

  1. Sklan E, Serrano R, Einav S, Pfeffer S, Lambright D, Glenn J. TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication. J Biol Chem. 2007;282:36354-61 pubmed
    ..TBC1D20 was found to be the first known GAP for Rab1, which is implicated in the regulation of anterograde traffic between the endoplasmic reticulum and the Golgi ..
  2. Hyvola N, Diao A, McKenzie E, Skippen A, Cockcroft S, Lowe M. Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J. 2006;25:3750-61 pubmed
    ..Strongest interaction is seen with Golgi-associated rab1 and rab6 and endosomal rab5...
  3. Haas A, Yoshimura S, Stephens D, Preisinger C, Fuchs E, Barr F. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. J Cell Sci. 2007;120:2997-3010 pubmed
    ..TBC1D20 is the ER-localized GAP for Rab1, and is the only GAP blocking the delivery of secretory cargo from the ER to the cell surface...
  4. Diao A, Rahman D, Pappin D, Lucocq J, Lowe M. The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. J Cell Biol. 2003;160:201-12 pubmed
    ..Golgin-84 binds to active rab1 but not cis-Golgi matrix proteins...
  5. Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T. Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER. FEBS Lett. 2001;508:201-9 pubmed
    ..A similar binding was seen to rab1 but not to rab6, both Golgi rabs...
  6. Moyer B, Allan B, Balch W. Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering. Traffic. 2001;2:268-76 pubmed
    ..We recently demonstrated that Rab1 recruitment of the tethering factor p115 into a cis-SNARE complex programs coat protein II vesicles budding from ..
  7. Allan B, Moyer B, Balch W. Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion. Science. 2000;289:444-8 pubmed
    The guanosine triphosphatase Rab1 regulates the transport of newly synthesized proteins from the endoplasmic reticulum to the Golgi apparatus through interaction with effector molecules, but the molecular mechanisms by which this occurs ..
  8. Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M. Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. Nature. 1991;350:715-8 pubmed
    ..This may provide a clue to the mechanism by which phosphorylation could affect membrane traffic during mitosis. ..
  9. Martincic I, Peralta M, Ngsee J. Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. J Biol Chem. 1997;272:26991-8 pubmed
    ..Using the yeast two-hybrid screen, we have isolated a rat clone that interacts with Rab3A as well as with Rab1. The gene encodes a 20.6-kDa protein with two extensive hydrophobic domains and is broadly expressed in all tissues...

More Information

Publications100

  1. Mukhopadhyay A, Quiroz J, Wolkoff A. Rab1a regulates sorting of early endocytic vesicles. Am J Physiol Gastrointest Liver Physiol. 2014;306:G412-24 pubmed publisher
    We previously reported that Rab1a is associated with asialoorosomucoid (ASOR)-containing early endocytic vesicles, where it is required for their microtubule-based motility...
  2. Sun T, Wang X, He H, Sweeney C, Liu S, Brown M, et al. MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A. Oncogene. 2014;33:2790-800 pubmed publisher
    ..By performing systematic biochemical and bioinformatical analyses, we identified two miR-221 targets, HECTD2 and RAB1A, which could mediate the development of CRPC phenotype in multiple prostate cancer cell lines...
  3. Wang C, Yoo Y, Fan H, Kim E, Guan K, Guan J. Regulation of Integrin ? 1 recycling to lipid rafts by Rab1a to promote cell migration. J Biol Chem. 2010;285:29398-405 pubmed publisher
    b>Rab1a is a member of the Rab family of small GTPases with a well characterized function in the regulation of vesicle trafficking from the endoplasmic reticulum to the Golgi apparatus and within Golgi compartments...
  4. Neunuebel M, Mohammadi S, Jarnik M, Machner M. Legionella pneumophila LidA affects nucleotide binding and activity of the host GTPase Rab1. J Bacteriol. 2012;194:1389-400 pubmed publisher
    ..SidD, and LepB, were shown to target the early secretory pathway by manipulating the activity of the host GTPase Rab1. While the function of these effectors has been well characterized, the role of another Rab1-interacting protein ..
  5. Short B, Preisinger C, Korner R, Kopajtich R, Byron O, Barr F. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. J Cell Biol. 2001;155:877-83 pubmed
    ..The GTP form of rab1 regulates ER to Golgi transport by interaction with the vesicle tethering factor p115 and the cis-Golgi matrix ..
  6. Zenner H, Yoshimura S, Barr F, Crump C. Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment. J Virol. 2011;85:8012-21 pubmed publisher
    ..We identified that TBC1D20 and RN-tre and their partner Rabs, Rab1a/b and Rab43, respectively, are important for virion assembly...
  7. Satoh A, Wang Y, Malsam J, Beard M, Warren G. Golgin-84 is a rab1 binding partner involved in Golgi structure. Traffic. 2003;4:153-61 pubmed
    ..Golgin-84 is a membrane-anchored golgin that we now show binds preferentially to the GTP form of the rab1 GTPase. It is also present throughout the Golgi stack by immuno-EM...
  8. Weide T, Teuber J, Bayer M, Barnekow A. MICAL-1 isoforms, novel rab1 interacting proteins. Biochem Biophys Res Commun. 2003;306:79-86 pubmed
    b>Rab1 GTPases participate in regulating the vesicular transport of ER-Golgi compartments. Recently, GM130, p115, and Golgin-84 were identified as effectors of the active conformation of rab1...
  9. Nevo Yassaf I, Yaffe Y, Asher M, Ravid O, Eizenberg S, Henis Y, et al. Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A. J Virol. 2012;86:6491-502 pubmed publisher
    ..Moreover, TBC1D20 and its cognate GTPase Rab1 are recruited by NS5A to LDs. The NS5A-TBC1D20 interaction was shown to be essential for the viral life cycle...
  10. Mukhopadhyay A, Nieves E, Che F, Wang J, Jin L, Murray J, et al. Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles. J Cell Sci. 2011;124:765-75 pubmed publisher
    ..Several Rab GTPases, including Rab1a, were found...
  11. Nachmias D, Sklan E, Ehrlich M, Bacharach E. Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway. Retrovirology. 2012;9:7 pubmed publisher
    ..TBC1D20, the GTPase-activating protein (GAP) of Rab1, regulates endoplasmic reticulum (ER) to Golgi trafficking, was not identified in any of these screens, and its ..
  12. Fan S, Snell C, Turley H, Li J, McCormick R, Perera S, et al. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene. 2016;35:3004-15 pubmed publisher
    ..cell types, and in situ proximity ligation analysis shows that PAT4 interacts with both mTORC1 and its regulator Rab1A on the Golgi...
  13. Tisdale E, Talati N, Artalejo C, Shisheva A. GAPDH binds Akt to facilitate cargo transport in the early secretory pathway. Exp Cell Res. 2016;349:310-319 pubmed publisher
    ..Interestingly Rab1, which functions in anterograde-directed trafficking, stimulates GAPDH-Akt association with membranes in a ..
  14. Chae S, Kim S, Do Koo Y, Lee J, Kim H, Ahn B, et al. A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles. Exp Mol Med. 2018;50:129 pubmed publisher
    ..the DEPs, we selected two (NDUFS3 and COX2) for downregulated oxidative phosphorylation and three (CALR, SORT, and RAB1A) for upregulated calcium and protein transport as representative mitochondrial and MAM processes, respectively, ..
  15. Yoon Y, Pitts K, Dahan S, McNiven M. A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells. J Cell Biol. 1998;140:779-93 pubmed
    ..most strikingly, with endoplasmic reticulum tubules as verified by double labeling with antibodies to calnexin and Rab1 as well as by immunoelectron microscopy...
  16. Oswald M, West R, Lloyd Evans E, Sweeney S. Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1. Hum Mol Genet. 2015;24:6899-909 pubmed publisher
    ..could rescue sensory function in neurons expressing mutant dSpt1 by co-expressing an effector of ER-Golgi function, Rab1 suggesting compromised ER function in HSAN1 affected dendritic neurons...
  17. Wood R, Newton P, Latomanski E, Newton H. Dot/Icm Effector Translocation by Legionella longbeachae Creates a Replicative Vacuole Similar to That of Legionella pneumophila despite Translocation of Distinct Effector Repertoires. Infect Immun. 2015;83:4081-92 pubmed publisher
    ..We observed that the host Rab GTPase, Rab1, and the v-SNARE Sec22b are also recruited to the longbeachae-LCV during the early stages of infection, coinciding ..
  18. Shimura M, Mizuma M, Hayashi H, Mori A, Tachibana T, Hata T, et al. A long-term survival case treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis. Surg Case Rep. 2017;3:132 pubmed publisher
    ..Histological diagnosis was well-differentiated tubular adenocarcinoma, showing ypT1 ypN1 M1 stage IV, negative surgical margin (R0), and grade III in the Evans classification...
  19. Wang Q, Wang Y, Yu F. Yif1 associates with Yip1 on Golgi and regulates dendrite pruning in sensory neurons during Drosophila metamorphosis. Development. 2018;145: pubmed publisher
    ..Moreover, we show that two GTPases, Rab1 and Sar1, which are known to regulate ER-to-Golgi transport, are essential for dendrite pruning of ddaC neurons...
  20. Peinado H, Alečković M, Lavotshkin S, Matei I, Costa Silva B, Moreno Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18:883-91 pubmed publisher
    ..b>RAB1A, RAB5B, RAB7 and RAB27A, regulators of membrane trafficking and exosome formation, were highly expressed in ..
  21. Ke H, Feng Z, Liu M, Sun T, Dai J, Ma M, et al. Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements. J Genet Genomics. 2018;: pubmed publisher
    ..Our further analysis of the involvement of Rab-GTPases in secretion shows that Rab1, Rab2 and RabX3, are all required at ERES, each of them differentially affecting ERES morphology...
  22. Sittler A, Muriel M, Marinello M, Brice A, den Dunnen W, Alves S. Deregulation of autophagy in postmortem brains of Machado-Joseph disease patients. Neuropathology. 2017;: pubmed publisher
    ..Increase in the levels of lysosomal-associated membrane protein 2 (LAMP-2) and of the endosomal markers (Rab7 and Rab1A) were observed in MJD patients relatively to controls...
  23. Puvar K, Iyer S, Sheedlo M, Das C. Purification and functional characterization of the DUB domain of SdeA. Methods Enzymol. 2019;618:343-355 pubmed publisher
    ..Several mammalian Rab proteins (Rab1, Rab30, and Rab33) have been shown to be targeted...
  24. Lipatova Z, Segev N. A Role for Macro-ER-Phagy in ER Quality Control. PLoS Genet. 2015;11:e1005390 pubmed publisher
    ..three sequential steps of this pathway are delineated: Atg9-dependent exit from the ER en route to autophagy, Ypt1- and core Atgs-mediated pre-autophagsomal-structure organization, and Ypt51-mediated delivery of APs to the vacuole...
  25. De Benedictis P, Minola A, Rota Nodari E, Aiello R, Zecchin B, Salomoni A, et al. Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis. EMBO Mol Med. 2016;8:407-21 pubmed publisher
    ..They showed higher potency and breath compared to antibodies under clinical development (namely CR57, CR4098, and RAB1) and commercially available human RIG...
  26. Peurois F, Veyron S, Ferrandez Y, Ladid I, Benabdi S, Zeghouf M, et al. Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering. Biochem J. 2017;474:1259-1272 pubmed publisher
    ..the exceptional affinity of the bacterial RabGEF DrrA for the phosphoinositide PI(4)P delimits the activation of Rab1 to the immediate vicinity of the membrane-bound GEF...
  27. Yang Y, Hou N, Wang X, Wang L, Chang S, He K, et al. miR-15b-5p induces endoplasmic reticulum stress and apoptosis in human hepatocellular carcinoma, both in vitro and in vivo, by suppressing Rab1A. Oncotarget. 2015;6:16227-38 pubmed
    ..Our results were consistent with the report. Using bioinformatics and luciferase reporter assays, we identified Rab1A as a novel and direct target of miR-15b-5p...
  28. Liu N, Sun C, Cui G, Wei P, Yang L, Sun W, et al. The Rab1 in host cells modulates Brucella intracellular survival and binds to Brucella DnaK protein. Arch Microbiol. 2016;198:923-31 pubmed publisher
    ..and replicates inside host cells within the Brucella-containing vacuole, in which membrane contains a small GTPase Rab1. Here, we reported that Rab1 mediates B. abortus intracellular growth. Furthermore, B...
  29. Farg M, Sundaramoorthy V, Sultana J, Yang S, Atkinson R, Levina V, et al. C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet. 2014;23:3579-95 pubmed publisher
    ..C9ORF72 colocalized with Rab proteins implicated in autophagy and endocytic transport: Rab1, Rab5, Rab7 and Rab11 in neuronal cell lines, primary cortical neurons and human spinal cord motor neurons, ..
  30. Lukman S, Nguyen M, Sim K, Teo J. Discovery of Rab1 binding sites using an ensemble of clustering methods. Proteins. 2017;85:859-871 pubmed publisher
    ..and therapeutic applications is an attractive strategy in proteins that share common native ligands, as in Rab1 protein. Rab1 is a subfamily member of Rab proteins, which are members of Ras GTPase superfamily...
  31. Pieper L, Strotbek M, Wenger T, Gamer M, Olayioye M, Hausser A. Secretory pathway optimization of CHO producer cells by co-engineering of the mitosRNA-1978 target genes CerS2 and Tbc1D20. Metab Eng. 2017;40:69-79 pubmed publisher
    ..sequencing we identified two endoplasmic reticulum (ER)-localized proteins, Ceramide Synthase 2 (CerS2) and the Rab1 GAP Tbc domain family member 20 (Tbc1D20), as target genes of mitosRNA-1978...
  32. Ramírez Peinado S, Ignashkova T, van Raam B, Baumann J, Sennott E, Gendarme M, et al. TRAPPC13 modulates autophagy and the response to Golgi stress. J Cell Sci. 2017;130:2251-2265 pubmed publisher
    ..the TRAPP complex acts as a guanine nucleotide exchange factor (GEF) for Ypt1, which is homologous to human Rab1a and Rab1b...
  33. Sprenger T, Rothe H, Beissbarth T, Conradi L, Kauffels A, Homayounfar K, et al. [Lymph node metastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy : The Achilles heel of organ-preserving operative procedures?]. Chirurg. 2016;87:593-601 pubmed publisher
    ..cancer and complete remission (ypT0) or with good response and residual tumor restricted only to the bowel wall (ypT1-2) after neoadjuvant chemoradiotherapy (CRT), local excision has been suggested as an alternative to avoid the ..
  34. Li C, Luo X, Zhao S, Siu G, Liang Y, Chan H, et al. COPI-TRAPPII activates Rab18 and regulates its lipid droplet association. EMBO J. 2017;36:441-457 pubmed publisher
    ..identified as a vesicle tethering factor in yeast and as a guanine nucleotide exchange factor (GEF) for Ypt1/Rab1. In mammals, structures and functions of various TRAPP complexes are beginning to be understood...
  35. Rizzo G, Zaccone G, Magnocavallo M, Mattana C, Pafundi D, Gambacorta M, et al. Transanal endoscopic microsurgery after neoadjuvant radiochemotherapy for locally advanced extraperitoneal rectal cancer. Eur J Surg Oncol. 2017;43:1488-1493 pubmed publisher
    ..6% (no grade ?3). At pathological analysis, 23 specimens were ypT0 TRG1, and 4 were ypT1 TRG2. In 9 cases (ypT>1 and/or TRG>2), radical surgery with TME was proposed but 3 refused it...
  36. Soo K, Halloran M, Sundaramoorthy V, Parakh S, Toth R, Southam K, et al. Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS. Acta Neuropathol. 2015;130:679-97 pubmed publisher
    ..Each protein inhibited transport by distinct mechanisms, but each process was dependent on Rab1. Mutant TDP-43 and mutant FUS both inhibited the incorporation of secretory protein cargo into COPII vesicles as ..
  37. Jánó Z, Mohos E, Kovacs T, Berki C, Nagy T, Reti G, et al. [Retrospective analysis of carcinomas of the rectum operated by TEM during one year at our institute]. Magy Seb. 2016;69:141-149 pubmed
    ..17 patients received preoperative RCT, (4 ypT0, 2 ypT1, 3 ypT2, 8 ypT3). In the pTis group one patient was lost to follow up. Local recurrence was noted in 2 cases (14...
  38. Ishida M, Ohbayashi N, Fukuda M. Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Sci Rep. 2015;5:8238 pubmed publisher
    ..Here we discovered that small GTPase Rab1A on melanosomes recruits SKIP/PLEKHM2 as a Rab1A-specific effector and that Rab1A, SKIP, and a kinesin-1/(Kif5b+..
  39. Striegl H, Roske Y, Kümmel D, Heinemann U. Unusual armadillo fold in the human general vesicular transport factor p115. PLoS ONE. 2009;4:e4656 pubmed publisher
    ..The golgin p115 is targeted by the GTPase Rab1a, contains a large globular head region and a long region of coiled-coil which forms an extended rod-like structure...
  40. Lamb C, Nühlen S, Judith D, Frith D, Snijders A, Behrends C, et al. TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. EMBO J. 2016;35:281-301 pubmed publisher
    ..In this study, we identify the TRAPP complex, a multi-subunit tethering complex and GEF for RAB1, as an interactor of TBC1D14...
  41. Hass H, Vogel U, Scheurlen M, Jobst J. Gene-expression Analysis Identifies Specific Patterns of Dysregulated Molecular Pathways and Genetic Subgroups of Human Hepatocellular Carcinoma. Anticancer Res. 2016;36:5087-5095 pubmed
    ..g. Rac GTPase activating protein 1 (RACGAP1), Rab GTPase YPT1 homolog (RAB1), and ADP-ribosylation factor-like 2 (ARL2)] and extracellular matrix re-modelling or cytoskeleton ..
  42. Campbell Valois F, Sachse M, Sansonetti P, Parsot C. Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA. MBio. 2015;6:e02567-14 pubmed publisher
    ..The effector VirA, a GTPase-activating protein (GAP) for Rab1, was also shown to prevent LC3 recruitment. However, the context of LC3 recruitment around S...
  43. Monteiro A, Sumagin R, Rankin C, Leoni G, Mina M, Reiter D, et al. JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. Mol Biol Cell. 2013;24:2849-60 pubmed publisher
    ..These results suggest that JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. ..
  44. Mukherjee I, Barlowe C. Overexpression of Sly41 suppresses COPII vesicle-tethering deficiencies by elevating intracellular calcium levels. Mol Biol Cell. 2016;27:1635-49 pubmed publisher
    SLY41 was identified as a multicopy suppressor of loss of Ypt1, a Rab GTPase essential for COPII vesicle tethering at the Golgi complex...
  45. Smart C, Korsgen S, Hill J, Speake D, Levy B, Steward M, et al. Multicentre study of short-course radiotherapy and transanal endoscopic microsurgery for early rectal cancer. Br J Surg. 2016;103:1069-75 pubmed publisher
    ..Histopathological staging identified 20 ypT0 tumours, 23 ypT1, 18 ypT2 and one ypT3...
  46. Voss S, Krüger D, Koch O, Wu Y. Spatiotemporal imaging of small GTPases activity in live cells. Proc Natl Acad Sci U S A. 2016;113:14348-14353 pubmed
    ..The COSGAs allow for monitoring of Rab1 and K-Ras activity in live cells using fluorescence lifetime imaging microscopy...
  47. Garcia Aguilar J, Renfro L, Chow O, Shi Q, Carrero X, Lynn P, et al. Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial. Lancet Oncol. 2015;16:1537-46 pubmed publisher
    ..patients (intention-to-treat population) and for patients who completed chemotherapy and radiation, and had ypT0, ypT1, or ypT2 tumours, and negative resection margins (per-protocol group). This study is registered with ClinicalTrials...
  48. Gustafson M, Fromme J. Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments. Mol Biol Cell. 2017;28:3660-3671 pubmed publisher
    ..We also identify the small GTPase Ypt1 as a recruiter for Gea1 and Gea2...
  49. Kakuta S, Yamaguchi J, Suzuki C, Sasaki M, Kazuno S, Uchiyama Y. Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation. FASEB J. 2017;31:3757-3773 pubmed publisher
    ..One of the proteins obtained via proteomic analyses of the mammalian ATG9A vesicle was Rab1, a small GTPase that is essential in endoplasmic reticulum-to-Golgi vesicle trafficking...
  50. Rak A, Pylypenko O, Niculae A, Pyatkov K, Goody R, Alexandrov K. Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell. 2004;117:749-60 pubmed
  51. Kim J, Lipatova Z, Majumdar U, Segev N. Regulation of Golgi Cisternal Progression by Ypt/Rab GTPases. Dev Cell. 2016;36:440-52 pubmed publisher
    ..Moreover, controversy about the placement of two of the founding members of the Ypt/Rab family, Ypt1 and Ypt31, to specific Golgi cisternae interferes with addressing this question in yeast, where cisternal ..
  52. Zhou F, Zou S, Chen Y, Lipatova Z, Sun D, Zhu X, et al. A Rab5 GTPase module is important for autophagosome closure. PLoS Genet. 2017;13:e1007020 pubmed publisher
    ..In yeast, an autophagy-specific Ypt1 GTPase module, together with a set of autophagy-related proteins (Atgs) and a phosphatidylinositol-3-phosphate (..
  53. Bao S, Zhu J, Garvey W. Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects. Horm Metab Res. 1998;30:656-62 pubmed
    ..Multiple Rab isoforms including Rab1A, Rab4A, Rab5B, Rab7, Rab8, Rab10, Rab12A, Rab13, Rab18, Rab21, and Rab22 mRNA were found to be expressed in human ..
  54. Lin J, Wang C, Liang W, Zhang J, Zhang L, Lv H, et al. Rab1A is required for assembly of classical swine fever virus particle. Virology. 2018;514:18-29 pubmed publisher
    b>Rab1A belongs to the small Rab GTPase family and is involved in the lifecycle of numerous viruses. Here, knockdown of Rab1A inhibited CSFV growth...
  55. Cremers F, Armstrong S, Seabra M, Brown M, Goldstein J. REP-2, a Rab escort protein encoded by the choroideremia-like gene. J Biol Chem. 1994;269:2111-7 pubmed
    ..proteins were approximately equal in facilitating the attachment of GG groups to several Rab proteins, including Rab1A, Rab5A, and Rab6. However, REP-2 was only 25% as active as REP-1 in supporting GG attachment to Rab3A and Rab3D...
  56. Farnsworth C, Seabra M, Ericsson L, Gelb M, Glomset J. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc Natl Acad Sci U S A. 1994;91:11963-7 pubmed
    ..geranylgeranyltransferase, Rab escort protein, and [1-3H]geranylgeranyl pyrophosphate with recombinant wild-type Rab1A (-XXCC), Rab3A (-XCXC), or Rab5A (-CCXX) and treated each labeled protein with trypsin...
  57. Suh H, Lee D, Lee K, Ku B, Choi S, Woo J, et al. Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. EMBO J. 2010;29:496-504 pubmed publisher
    ..Here, we present the structure of a SidM/DrrA fragment possessing dual GEF and GDF activity in complex with Rab1. SidM/DrrA reconfigures the Switch regions of the GTPase domain of Rab1, as eukaryotic GEFs do toward cognate Rabs...
  58. Wang J, Menon S, Yamasaki A, Chou H, Walz T, Jiang Y, et al. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Proc Natl Acad Sci U S A. 2013;110:9800-5 pubmed publisher
    ..The Rab GTPase Ypt1 and its mammalian homolog Rab1 regulate macroautophagy and two other trafficking events: endoplasmic reticulum-Golgi and intra-Golgi traffic...
  59. King G, Stöckli J, Hu S, Winnen B, Duprez W, Meoli C, et al. Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase. J Biol Chem. 2012;287:40996-1006 pubmed publisher
    ..Isothermal titration calorimetry data reveal the interaction between APPL2 and Rab31 has a K(d) of 140 nM. Together with other biophysical data, we conclude the stoichiometry of the complex is 2:2. ..
  60. Solis G, Bilousov O, Koval A, Lüchtenborg A, Lin C, Katanaev V. Golgi-Resident G?o Promotes Protrusive Membrane Dynamics. Cell. 2017;170:939-955.e24 pubmed publisher
    ..We further find small Golgi-residing GTPases Rab1 and Rab3 as direct effectors of G?o...
  61. Baksi S, Singh N. ?-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson's disease. Sci Rep. 2017;7:12843 pubmed publisher
    ..Over-expression of Rab1a restores ferritinophagy, suggesting that ?-syn impairs lysosomal function by disrupting the trafficking of ..
  62. Allgood S, Romero Dueñas B, Noll R, Pike C, Lein S, Neunuebel M. Legionella Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner. Front Cell Infect Microbiol. 2017;7:397 pubmed publisher
    ..The Legionella effector AnkX is a phosphocholine transferase that covalently modifies host Rab1 and Rab35...
  63. Wang X, Liu F, Qin X, Huang T, Huang B, Zhang Y, et al. Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage. Aging (Albany NY). 2016;8:2790-2798 pubmed publisher
    b>Rab1A expression is associated with malignant phenotypes in several human tumors; however, the role of Rab1A in lung cancer is still unclear. In this study, we attempted to establish the role of Rab1A in major human lung cancer subtypes...
  64. Wedemeyer N, Lengeling A, Ronsiek M, Korthaus D, Baer K, Wuttke M, et al. YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p. Genomics. 1996;32:447-54 pubmed
    ..We have localized the wobbler spinal atrophy gene wr to proximal mouse Chr 11, tightly linked to Rab1, a gene coding for a small GTP-binding protein, and Glnsps1, an intronless pseudogene of the glutamine synthetase ..
  65. Khan M, Li B, Jiang Y, Weng Q, Chen Q. Evaluation of Different PCR-Based Assays and LAMP Method for Rapid Detection of Phytophthora infestans by Targeting the Ypt1 Gene. Front Microbiol. 2017;8:1920 pubmed publisher
    ..nested PCR, and real-time PCR to verify and compare the sensitivity and specificity of the reaction based on the Ypt1 (Ras-related protein) gene of P. infestans...
  66. Romano J, Nolan S, Porter C, Ehrenman K, Hartman E, Hsia R, et al. The parasite Toxoplasma sequesters diverse Rab host vesicles within an intravacuolar network. J Cell Biol. 2017;216:4235-4254 pubmed publisher
    ..Correlative light and electron microscopy analysis of infected cells illustrates that intravacuolar Rab1A vesicles are surrounded by the PV membrane, suggesting a phagocytic-like process for vesicle engulfment...
  67. Russo A, Mathiowetz A, Hong S, Welch M, Campellone K. Rab1 recruits WHAMM during membrane remodeling but limits actin nucleation. Mol Biol Cell. 2016;27:967-78 pubmed publisher
    ..We found that Rab1 stimulated the formation and elongation of WHAMM-associated membrane tubules in cells...
  68. Burton J, Roberts D, Montaldi M, Novick P, De Camilli P. A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4. Nature. 1993;361:464-7 pubmed
    ..The protein Sec4, a member of the Sec4/Ypt1/Rab branch of the Ras superfamily, is involved in a late stage of the secretory pathway in yeast...
  69. Fuchs E, Short B, Barr F. Assay and properties of rab6 interaction with dynein-dynactin complexes. Methods Enzymol. 2005;403:607-18 pubmed
    ..Standard protocols for yeast two-hybrid analysis, and biochemical assays for the analysis of the interactions between Rab6, Bicaudal-D, and the subunits of the dynein-dynactin complex are outlined. ..
  70. Wang J, Davis S, Menon S, Zhang J, Ding J, Cervantes S, et al. Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER-Golgi traffic and macroautophagy. J Cell Biol. 2015;210:273-85 pubmed publisher
    ..Instead, we show here that the Rab GTPase Ypt1/Rab1 binds and activates Hrr25/CK1δ to spatially regulate its kinase activity...
  71. Thomas J, Zhang Y, Wei Y, Cho J, Morris L, Wang H, et al. Rab1A is an mTORC1 activator and a colorectal oncogene. Cancer Cell. 2014;26:754-69 pubmed publisher
    ..Here we describe the identification of Rab1 as a conserved regulator of AA signaling to mTORC1. AA stimulates Rab1A GTP binding and interaction with mTORC1 and Rheb-mTORC1 interaction in the Golgi...
  72. Blanco Meneses M, Carbone I, Ristaino J. Population structure and migration of the Tobacco Blue Mold Pathogen, Peronospora tabacina into North America and Europe. Mol Ecol. 2017;: pubmed publisher
    ..Two nuclear loci, Igs2 and Ypt1 and one mitochondrial locus, cox2, were amplified, cloned and sequenced from fifty four isolates of P...
  73. Zhang X, Wang G, Dupre D, Feng Y, Robitaille M, Lazartigues E, et al. Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. J Pharmacol Exp Ther. 2009;330:109-17 pubmed publisher
    ..In this report, we determined the role of Rab1 GTPase, which specifically controls protein transport from the endoplasmic reticulum (ER) to the Golgi, and ..
  74. Karniguian A, Zahraoui A, Tavitian A. Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. Proc Natl Acad Sci U S A. 1993;90:7647-51 pubmed
    ..This study has shown that rab1, rab3B, rab4, rab6, and rab8 proteins, but not rab3A protein, were present in platelets and in endothelial cells...
  75. Janoueix Lerosey I, Jollivet F, Camonis J, Marche P, Goud B. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6. J Biol Chem. 1995;270:14801-8 pubmed
    ..GDI beta is functional; we show that recombinant mouse GDI beta is able to remove several Rab proteins, including Rab1, Rab2, Rab4, and Rab6, from membranes...
  76. Yuan H, Davis S, Ferro Novick S, Novick P. Rewiring a Rab regulatory network reveals a possible inhibitory role for the vesicle tether, Uso1. Proc Natl Acad Sci U S A. 2017;114:E8637-E8645 pubmed publisher
    b>Ypt1 and Sec4 are essential Rab GTPases that control the early and late stages of the yeast secretory pathway, respectively...
  77. Hammad M, Kuang Y, Morse A, Dupre D. Rab1 interacts directly with the ?2-adrenergic receptor to regulate receptor anterograde trafficking. Biol Chem. 2012;393:541-6 pubmed publisher
    ..We evaluated the potential interaction of Rab1, a GTPase known to regulate ?2-adrenergic receptor (?2AR) trafficking, and its effect on export from the ER...
  78. Vielh E, Touchot N, Zahraoui A, Tavitian A. Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT related protein. Nucleic Acids Res. 1989;17:1770 pubmed
  79. Frappaolo A, Sechi S, Kumagai T, Robinson S, Fraschini R, Karimpour Ghahnavieh A, et al. COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. J Cell Sci. 2017;130:3637-3649 pubmed publisher
    ..We demonstrate that the COG complex cooperates with Rab1 and Golgi phosphoprotein 3 to regulate Golgi trafficking and that overexpression of Rab1 can rescue the cytokinesis ..
  80. Madero Pérez J, Fdez E, Fernández B, Lara Ordóñez A, Blanca Ramírez M, Romo Lozano M, et al. Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes. Biochem Soc Trans. 2017;45:147-154 pubmed publisher
    ..In light of these findings, we here review the link between cellular deficits in intracellular trafficking pathways and the LRRK2-mediated phosphorylation of those newly identified substrates. ..
  81. Zhang C, Cao Y, Fu J, Yun J, Zhang M. miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33. Mol Oncol. 2016;10:1532-1541 pubmed publisher
    ..Mechanistically, miR-634 inhibited the expression of Rab1A and DHX33 via directly binding to the 3'-UTR of both genes...
  82. Megger D, Rosowski K, Ahrens M, Bracht T, Eisenacher M, Schlaak J, et al. Tissue-based quantitative proteome analysis of human hepatocellular carcinoma using tandem mass tags. Biomarkers. 2017;22:113-122 pubmed publisher
    ..Among several significantly upregulated proteins, translocator protein 18 (TSPO) and Ras-related protein Rab-1A (RAB1A) were selected for verification by immunohistochemistry in an independent cohort...
  83. Schöppner P, Csaba G, Braun T, Daake M, Richter B, Lange O, et al. Regulatory Implications of Non-Trivial Splicing: Isoform 3 of Rab1A Shows Enhanced Basal Activity and Is Not Controlled by Accessory Proteins. J Mol Biol. 2016;428:1544-57 pubmed publisher
    ..The human small G-protein Rab1A is involved in the regulation of the vesicle transfer from the ER to Golgi...
  84. Timani K, Liu Y, Suvannasankha A, He J. Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15. Int J Biochem Cell Biol. 2014;54:10-9 pubmed publisher
    ..Interestingly, USP15 knockdown restored hTip110 protein expression in Tg MEF and USP15 expression had little effects. Taken together, these results provide insights into the regulatory mechanism of human Tip110 degradation by USP15. ..
  85. Coune P, Bensadoun J, Aebischer P, Schneider B. Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease. J Parkinsons Dis. 2011;1:373-87 pubmed publisher
    ..To address this question, we co-expressed human alpha-synuclein with Rab1A, a regulator of ER-to-Golgi vesicular trafficking, and found a significant reduction of Golgi fragmentation...
  86. Mishra A, Del Campo C, Collins R, Roy C, Lambright D. The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. J Biol Chem. 2013;288:24000-11 pubmed publisher
    ..Here, we report the transition state mimetic structure of the Legionella pneumophila GAP LepB in complex with Rab1 and describe a comprehensive structure-based mutational analysis of potential catalytic and recognition ..
  87. Kirsten M, Baron R, Seabra M, Ces O. Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy. Mol Membr Biol. 2013;30:303-14 pubmed publisher
  88. Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, Shao F. Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses. Cell. 2012;150:1029-41 pubmed publisher
    ..Specific inactivation of Rab1 by VirA/EspG disrupts ER-to-Golgi trafficking. S...
  89. Huang J, Birmingham C, Shahnazari S, Shiu J, Zheng Y, Smith A, et al. Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase. Autophagy. 2011;7:17-26 pubmed
    ..b>Rab1 also localized to autophagosomes, and its activity was required for autophagosome formation, clearance of protein ..
  90. Quan Y, Song Q, Wang J, Zhao L, Lv J, Gong S. MiR-1202 functions as a tumor suppressor in glioma cells by targeting Rab1A. Tumour Biol. 2017;39:1010428317697565 pubmed publisher
    ..in clinical glioma tissues and cell lines, and miR-1202 expression was inversely correlated with the expression of Rab1A. Using bioinformatics and luciferase reporter assays, we identified Rab1A as a novel and direct target of miR-1202...
  91. Xu B, Li X, Yang Y, Zhang M, Rao H, Wang H, et al. Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A. Oncotarget. 2015;6:20813-28 pubmed
    ..b>Rab1A is a newly identified mTORC1 activator that mediates an alternative amino acid (AA) signaling branch to Rag ..