RAB18

Summary

Gene Symbol: RAB18
Description: RAB18, member RAS oncogene family
Alias: RAB18LI1, WARBM3, ras-related protein Rab-18, RAB18 small GTPase
Species: human
Products:     RAB18

Top Publications

  1. Salloum S, Wang H, Ferguson C, Parton R, Tai A. Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. PLoS Pathog. 2013;9:e1003513 pubmed publisher
    ..Using an unbiased proteomic strategy, we have found that Rab18 interacts with the HCV nonstructural protein NS5A...
  2. Handley M, Morris Rosendahl D, Brown S, MacDonald F, Hardy C, Bem D, et al. Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome. Hum Mutat. 2013;34:686-96 pubmed publisher
    ..Causative biallelic germline mutations have been identified in RAB3GAP1, RAB3GAP2, or RAB18, each of which encode proteins involved in membrane trafficking...
  3. Ozeki S, Cheng J, Tauchi Sato K, Hatano N, Taniguchi H, Fujimoto T. Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. J Cell Sci. 2005;118:2601-11 pubmed
    ..In the present study, we identified Rab18 as an LD component of HepG2 cells by proteomic analysis, and confirmed its localization by immunohistochemistry ..
  4. Dejgaard S, Murshid A, Erman A, Kizilay O, Verbich D, Lodge R, et al. Rab18 and Rab43 have key roles in ER-Golgi trafficking. J Cell Sci. 2008;121:2768-81 pubmed publisher
    ..Further analysis of two of these proteins, Rab18 and Rab43, strongly indicated roles in ER-Golgi trafficking...
  5. Bem D, Yoshimura S, Nunes Bastos R, Bond F, Bond F, Kurian M, et al. Loss-of-function mutations in RAB18 cause Warburg micro syndrome. Am J Hum Genet. 2011;88:499-507 pubmed publisher
    ..mapping in five consanguineous families without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18. A c.71T > A (p...
  6. Martin S, Driessen K, Nixon S, Zerial M, Parton R. Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J Biol Chem. 2005;280:42325-35 pubmed
    ..In contrast, GFP-Rab18 localized to LDs and immunoelectron microscopy showed direct association with the monolayer surface...
  7. Handley M, Aligianis I. RAB3GAP1, RAB3GAP2 and RAB18: disease genes in Micro and Martsolf syndromes. Biochem Soc Trans. 2012;40:1394-7 pubmed publisher
    ..Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2...
  8. Lutcke A, Parton R, Murphy C, Olkkonen V, Dupree P, Valencia A, et al. Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression. J Cell Sci. 1994;107 ( Pt 12):3437-48 pubmed
    ..mRNA expression in different tissues and the intracellular localization in organ cryosections of two rab proteins, rab18 and rab20...
  9. Liegel R, Handley M, Ronchetti A, Brown S, Langemeyer L, Linford A, et al. Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am J Hum Genet. 2013;93:1001-14 pubmed publisher
    ..disorders characterized by eye, brain, and endocrine abnormalities caused by mutations in RAB3GAP1, RAB3GAP2, and RAB18. Sequence analysis of a cohort of 77 families affected by WARBM identified five distinct TBC1D20 loss-of-function ..

More Information

Publications73

  1. Kaushal M. Microbes in Cahoots with Plants: MIST to Hit the Jackpot of Agricultural Productivity during Drought. Int J Mol Sci. 2019;20: pubmed publisher
    ..differential expression of various genes such as ERD15 (Early Response to Dehydration 15), RAB18 (ABA-responsive gene) in Arabidopsis, COX1 (regulates energy and carbohydrate metabolism), ..
  2. Wu B, Qi R, Liu X, Qian L, Wu Z. Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer. Onco Targets Ther. 2018;11:7805-7820 pubmed publisher
    Dysregulation of Rab18 has been implicated in human cancers. However, its clinical significance and biological function in gastric cancer have not been investigated...
  3. Dejgaard S, Presley J. Rab18: new insights into the function of an essential protein. Cell Mol Life Sci. 2019;76:1935-1945 pubmed publisher
    b>Rab18 is one of the small number of conserved Rab proteins which have been traced to the last eukaryotic common ancestor...
  4. Li D, Zhao Y, Li D, Zhao H, Huang J, Miao G, et al. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. Cell Rep. 2019;27:343-358.e5 pubmed publisher
    ..DFCP1 acts as a Rab18 effector for LD localization and interacts with the Rab18-ZW10 complex to mediate ER-LD contact formation...
  5. Pei L, Peng L, Wan X, Xiong J, Liu Z, Li X, et al. Expression Pattern and Function Analysis of AtPPRT1, a Novel Negative Regulator in ABA and Drought Stress Responses in Arabidopsis. Int J Mol Sci. 2019;20: pubmed publisher
    ..by quantitative real-time PCR (qRT-PCR) revealed that the expression of three stress-inducible genes (AtRAB18, AtERD10, and AtKIN1) were upregulated in the atpprt1 mutant and downregulated in ..
  6. Nian F, Li L, Cheng C, Wu P, Lin Y, Tang C, et al. Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B. Mol Neurobiol. 2019;: pubmed publisher
    Mutations in RAB18, a member of small G protein, cause Warburg micro syndrome (WARBM), whose clinical features include vision impairment, postnatal microcephaly, and lower limb spasticity...
  7. Hernández Sánchez I, Maruri López I, Molphe Balch E, Becerra Flora A, Jaimes Miranda F, Jiménez Bremont J. Evidence for in vivo interactions between dehydrins and the aquaporin AtPIP2B. Biochem Biophys Res Commun. 2019;510:545-550 pubmed publisher
    ..Furthermore, we also demonstrate the interaction of AtPIP2B with the three Arabidopsis dehydrins COR47 (AT1G20440), ERD10 (At1g20450), and RAB18 (At5g66400).
  8. O Mahony F, Wroblewski K, O Byrne S, Jiang H, Clerkin K, Benhammou J, et al. Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein. Hepatology. 2015;62:615-26 pubmed publisher
    ..We identify Rab18 as a novel retinoic acid-responsive, LD-associated protein that helps mediate stellate cell activation...
  9. Ma Y, Tian S, He S, Chen Q, Wang Z, Xiao X, et al. The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y. Gene. 2016;588:62-8 pubmed publisher
    ..We determined that miR-19b-3p could regulate the expression of not only USP32, RAB18 and Dusp6 but also FXR1, and FXR1 could in turn regulate the expression of miR-19b-3p...
  10. Shikanai M, Yuzaki M, Kawauchi T. Rab family small GTPases-mediated regulation of intracellular logistics in neural development. Histol Histopathol. 2018;33:765-771 pubmed publisher
    ..Many Rab proteins, such as Rab5, Rab6, Rab7, Rab8, Rab10, Rab11, Rab17 and Rab18, are shown to regulate neurite outgrowth in PC12 cells and/or axon and dendrite formation in primary cultured ..
  11. Zhong K, Chen K, Han L, Li B. MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18. BMC Cancer. 2014;14:703 pubmed publisher
    ..Both miR-30b and miR-30c (miR-30b/c) were found having target site in same region of Rab18 mRNA...
  12. Wu F, Li S, Zhang N, Huang W, Li X, Wang M, et al. Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy. Biomed Pharmacother. 2018;104:307-314 pubmed publisher
    ..proteomics and bioinformatics analysis revealed that the hispidulin-regulated Pim1 inhibition was associated to RAB18, NRas, PARK7, and FIS1...
  13. Gillingham A, Sinka R, Torres I, Lilley K, Munro S. Toward a comprehensive map of the effectors of rab GTPases. Dev Cell. 2014;31:358-73 pubmed publisher
    ..We confirm over 25 interactions for Rab2, Rab4, Rab5, Rab6, Rab7, Rab9, Rab18, Rab19, Rab30, and Rab39...
  14. Dubiel D, Bintig W, Kahne T, Dubiel W, Naumann M. Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis. Biochim Biophys Acta Mol Cell Res. 2017;1864:1405-1412 pubmed publisher
    ..Neddylation of Cul3 coincides with an increase of Rab18, a GTPase associated with LDs...
  15. Zhao B, Hu Y, Li J, Yao X, Liu K. BnaABF2, a bZIP transcription factor from rapeseed (Brassica napus L.), enhances drought and salt tolerance in transgenic Arabidopsis. Bot Stud. 2016;57:12 pubmed publisher
    ..and salt stresses is due to reduced water-loss rate and expression of stress-responsive genes such as RD29B, RAB18 and KIN2...
  16. Picker Minh S, Busche A, Hartmann B, Spors B, Klopocki E, Hübner C, et al. Large homozygous RAB3GAP1 gene microdeletion causes Warburg micro syndrome 1. Orphanet J Rare Dis. 2014;9:113 pubmed publisher
    ..WARBM1-4 can be caused by biallelic mutations of the RAB3GAP1 (RAB3 GTPase-activating protein 1), RAB3GAP2, RAB18 (RAS-associated protein RAB18), or TBC1D20 (TBC1 domain protein, member 20) gene, respectively...
  17. Nakamura H, Yamashita N, Kimura A, Kimura Y, Hirano H, Makihara H, et al. Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice. Genes Cells. 2016;21:1059-1079 pubmed publisher
    ..In addition, SNAP25, RAB18, FABP5, ARF5 and LDHA, which are related genes to schizophrenia and methamphetamine sensitization, are also ..
  18. Coulter M, Dorobantu C, Lodewijk G, Delalande F, Cianférani S, Ganesh V, et al. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018;24:973-986.e8 pubmed publisher
    ..Furthermore, we show CHMP1A is important for release of an EV subtype that contains AXL, RAB18, and TMED10 (ART) and SHH...
  19. Zhang J, Chang D, Yang Y, Zhang X, Tao W, Jiang L, et al. Systematic investigation on the intracellular trafficking network of polymeric nanoparticles. Nanoscale. 2017;9:3269-3282 pubmed publisher
    ..in our research: the macropinocytosis (Rab34 positive)-LE (Rab7 positive)-lysosome pathway and the EE-liposome (Rab18)-lysosome pathway...
  20. Mhlanga Mutangadura T, Johnson G, Schnabel R, Taylor J, Johnson G, Katz M, et al. A mutation in the Warburg syndrome gene, RAB3GAP1, causes a similar syndrome with polyneuropathy and neuronal vacuolation in Black Russian Terrier dogs. Neurobiol Dis. 2016;86:75-85 pubmed publisher
    ..RAB3GAP1 encodes the catalytic subunit of a GTPase activator protein and guanine exchange factor for Rab3 and Rab18 respectively...
  21. Kim E, Seo Y, Park K, Kim S, Kim W. Overexpression of CaDSR6 increases tolerance to drought and salt stresses in transgenic Arabidopsis plants. Gene. 2014;552:146-54 pubmed publisher
    ..The expression of drought-induced marker genes, such as RD20, RD22, RD26, RD29A, RD29B, RAB18, KIN2, ABF3, and ABI5, was markedly increased in CaDSR6-overexpressing plants relative to wild type plants under ..
  22. Wu Q, Sun X, Yue W, Lu T, Ruan Y, Chen T, et al. RAB18, a protein associated with Warburg Micro syndrome, controls neuronal migration in the developing cerebral cortex. Mol Brain. 2016;9:19 pubmed publisher
    Loss of function mutations in RAB18, has been identified in patients with the human neurological and developmental disorder Warburg Micro syndrome. However, the function of RAB18 in brain remains unknown...
  23. Carpanini S, McKie L, Thomson D, Wright A, Gordon S, Roche S, et al. A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton. Dis Model Mech. 2014;7:711-22 pubmed publisher
    Mutations in RAB18 have been shown to cause the heterogeneous autosomal recessive disorder Warburg Micro syndrome (WARBM). Individuals with WARBM present with a range of clinical symptoms, including ocular and neurological abnormalities...
  24. Harris J, Dave K, Gorman J, Khanna K. The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking. Int J Biochem Cell Biol. 2018;99:28-37 pubmed publisher
    ..and mass spectrometry, we identified interactions between 5T4 and the membrane trafficking proteins Rab11, Rab18 and ARF6...
  25. Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, et al. Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. J Cell Biol. 2018;217:975-995 pubmed publisher
    ..However, the molecular link mediating ER and LD cross talk remains elusive. Here, we identified Rab18 as an important Rab guanosine triphosphatase in controlling LD growth and maturation...
  26. Babula Skowrońska D, Ludwików A, Cieśla A, Olejnik A, Cegielska Taras T, Bartkowiak Broda I, et al. Involvement of genes encoding ABI1 protein phosphatases in the response of Brassica napus L. to drought stress. Plant Mol Biol. 2015;88:445-57 pubmed publisher
    ..to drought showed a decrease in relative water content, photosynthetic pigments content and expression level of RAB18- and RD19A-drought-responsive marker genes relative to WT plants...
  27. Mateus D, Marini E, Progida C, Bakke O. Rab7a modulates ER stress and ER morphology. Biochim Biophys Acta Mol Cell Res. 2018;1865:781-793 pubmed publisher
    ..Recently, the small GTPases Rab10 and Rab18 were reported to control ER shape by regulating ER dynamics and fusion...
  28. Grasselli E, Voci A, Demori I, Vecchione G, Compalati A, Gallo G, et al. Triglyceride Mobilization from Lipid Droplets Sustains the Anti-Steatotic Action of Iodothyronines in Cultured Rat Hepatocytes. Front Physiol. 2015;6:418 pubmed publisher
    ..the lipid excess through the recruitment of ATGL on LD surface, and the modulation of the LD-associated proteins Rab18 and TIP47...
  29. Rasineni K, Penrice D, Natarajan S, McNiven M, McVicker B, Kharbanda K, et al. Alcoholic vs non-alcoholic fatty liver in rats: distinct differences in endocytosis and vesicle trafficking despite similar pathology. BMC Gastroenterol. 2016;16:27 pubmed publisher
    ..was measured in isolated hepatocytes, and content of selected trafficking proteins (Rab3D, Rab7 and Rab18) were determined in whole liver tissue...
  30. Lim C, Han S, Hwang I, Kim D, Hwang B, Lee S. The Pepper Lipoxygenase CaLOX1 Plays a Role in Osmotic, Drought and High Salinity Stress Response. Plant Cell Physiol. 2015;56:930-42 pubmed publisher
    ..In contrast, expression of the ABA-responsive marker genes RAB18 and RD29B was higher in CaLOX1-OX Arabidopsis plants than in wild-type plants...
  31. Arroyo Carrera I, de Zaldívar Tristancho M, Bermejo Sánchez E, Martínez Fernández M, López Lafuente A, Macdonald A, et al. Deletion 1q43-44 in a patient with clinical diagnosis of Warburg-Micro syndrome. Am J Med Genet A. 2015;167:1243-51 pubmed publisher
    ..This syndrome is caused by mutations in the RAB3GAP1/2 and RAB18 genes, part of the Rab family, and in the TBC1D20 gene, which contributes to lipid droplet formation/metabolism...
  32. Cheng C, Wu J, Tsai J, Nian F, Wu P, Kao L, et al. ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18. Exp Neurol. 2015;267:143-51 pubmed publisher
    Mutations in the gene of RAB18, a member of Ras superfamily of small G-proteins, cause Warburg Micro Syndrome (WARBM) which is characterized by defective neurodevelopmental and ophthalmological phenotypes...
  33. Jayson C, Arlt H, Fischer A, Lai Z, Farese R, Walther T. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 2018;29:2045-2054 pubmed publisher
    Rab GTPases recruit peripheral membrane proteins and can define organelle identity. Rab18 localizes to the endoplasmic reticulum (ER) but also to lipid droplets (LDs), where it has been implicated in effector protein recruitment and in ..
  34. Hao Q, Ren H, Zhu J, Wang L, Huang S, Liu Z, et al. Overexpression of PSK1, a SKP1-like gene homologue, from Paeonia suffruticosa, confers salinity tolerance in Arabidopsis. Plant Cell Rep. 2017;36:151-162 pubmed publisher
    ..under salinity stress: ASK1, LEAFY, FT, and CO involved in flower development and flowering time as well as P5CS, RAB18, DREB, and SOD1-3 contributing to salinity tolerance...
  35. Pereira M, Visbal G, Costa T, Frases S, de Souza W, Atella G, et al. Trypanosoma cruzi epimastigotes store cholesteryl esters in lipid droplets after cholesterol endocytosis. Mol Biochem Parasitol. 2018;224:6-16 pubmed publisher
    ..Fluorescence microscopy using BODIPY showed that LDs have high neutral lipid content and harbor Rab18, differently from other lipid-rich organelles (such as reservosomes)...
  36. Seok H, Nguyen L, Park H, Tarte V, Ha J, Lee S, et al. Arabidopsis non-TZF gene AtC3H17 functions as a positive regulator in salt stress response. Biochem Biophys Res Commun. 2018;498:954-959 pubmed publisher
    ..The transcription of the salt stress-responsive genes in ABA-dependent pathway, such as RAB18, COR15A, and RD22, was significantly higher in AtC3H17 OXs than in WT both under NaCl-free condition and after ..
  37. Shrestha B, Karki H, Groth D, Jungkhun N, Ham J. Biological Control Activities of Rice-Associated Bacillus sp. Strains against Sheath Blight and Bacterial Panicle Blight of Rice. PLoS ONE. 2016;11:e0146764 pubmed publisher
    ..The five selected RABs showing highest antimicrobial activities (RAB6, RAB9, RAB16, RAB17S, and RAB18) were closest to B. amyloliquefaciens in DNA sequence of 16S rDNA and gyrB, but to B. subtilis in that of recA...
  38. He M, Wang H, Z Liu Y, Gao W, Gao Y, Wang F, et al. Cloning and characterization of ChiMYB in Chrysanthemum indicum with an emphasis on salinity stress tolerance. Genet Mol Res. 2016;15: pubmed publisher
    ..Further investigation revealed that ChiMYB was able to regulate the expression of RD29A, RAB18, COR15, ABI1, and ABA genes, which are involved in salt stress signaling pathways...
  39. Dopie J, Rajakylä E, Joensuu M, Huet G, Ferrantelli E, Xie T, et al. Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators. J Cell Sci. 2015;128:2388-400 pubmed publisher
    ..19 factors as specific hits, and show that Chinmo (known as Bach2 in mammals), SNF4Aγ (Prkag1 in mammals) and Rab18 play a role in nuclear localization of actin in both fly and mammalian cells...
  40. Distéfano A, Valiñas M, Scuffi D, Lamattina L, ten Have A, García Mata C, et al. Phospholipase D δ knock-out mutants are tolerant to severe drought stress. Plant Signal Behav. 2015;10:e1089371 pubmed publisher
    ..We further analyzed the mutants and showed that pldδ have higher mRNA levels of RAB18 and RD29A compared to wild-type plants under normal growth conditions...
  41. Wu X, Qiao Z, Liu H, Acharya B, Li C, Zhang W. CML20, an Arabidopsis Calmodulin-like Protein, Negatively Regulates Guard Cell ABA Signaling and Drought Stress Tolerance. Front Plant Sci. 2017;8:824 pubmed publisher
    ..In the cml20 mutant, the transcripts of stress responsive genes, such as MYB2, RAB18, ERD10, COR47, and RD29A were up-regulated in response to drought and ABA, while down-regulated of ..
  42. Makino A, Hullin Matsuda F, Murate M, Abe M, Tomishige N, Fukuda M, et al. Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes. Mol Biol Cell. 2016;27:3293-3304 pubmed
    ..The results indicate that association of ApoB 100 with LDs is dependent on the activity of low-molecular weight GTP-binding protein Rab18 and highlight the role of LDs as targets of free cholesterol toxicity in hepatocytes.
  43. Bai C, Liu X, Xu J, Qiu C, Wang R, Zheng J. Expression profiles of stemness genes in gastrointestinal stromal tumor. Hum Pathol. 2018;76:76-84 pubmed publisher
    ..Furthermore, we confirmed RAS oncogene family (RAB18) and limb development membrane protein 1 (LMBR1) genes as novel targets for BMI1 in GIST cells...
  44. Park A, Liegel R, Ronchetti A, Ebert A, Geurts A, Sidjanin D. Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. BMC Genet. 2014;15:135 pubmed publisher
    ..In addition to TBC1D20, mutations in RAB3GAP1, RAB3GAP2 and RAB18 cause WARBM1-3 respectively...
  45. Liu J, Zhang J, Li Y, Wang L, Sui B, Dai D. MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18. Gene. 2016;592:308-15 pubmed publisher
    To detect the potential regulation pathway of microRNA-455-5p (miR-455-5p) and RAB18, member RAS oncogene family (RAB18) in gastric cancer (GC) cells and tissues and discuss the clinical significance of miR-455-5p in GC genesis and ..
  46. Ahmed I, Yadav D, Shukla P, Vineeth T, Sharma P, Kirti P. Constitutive expression of Brassica juncea annexin, AnnBj2 confers salt tolerance and glucose and ABA insensitivity in mustard transgenic plants. Plant Sci. 2017;265:12-28 pubmed publisher
    ..Furthermore, we found that overexpression of AnnBj2 upregulated the expression of ABA-dependent RAB18 and ABA-independent DREB2B stress marker genes suggesting that the tolerance phenotype exhibited by AnnBj2 OE ..
  47. Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, et al. The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem Biophys Res Commun. 2017;486:738-743 pubmed publisher
    ..Here, we show that the RAB GTPase RAB18 modulates autophagy in primary human fibroblasts...
  48. Hernández Sánchez I, Maruri López I, Graether S, Jiménez Bremont J. In vivo evidence for homo- and heterodimeric interactions of Arabidopsis thaliana dehydrins AtCOR47, AtERD10, and AtRAB18. Sci Rep. 2017;7:17036 pubmed publisher
    ..Our data revealed homodimeric RAB18 complexes in the nucleus and cytosol, while heterodimeric associations between AtRAB18 and acidic DHNs occurred ..
  49. Handley M, Carpanini S, Mali G, Sidjanin D, Aligianis I, Jackson I, et al. Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation. Open Biol. 2015;5:150047 pubmed publisher
    b>RAB18, RAB3GAP1, RAB3GAP2 and TBC1D20 are each mutated in Warburg Micro syndrome, a rare autosomal recessive multisystem disorder...
  50. Gerondopoulos A, Bastos R, Yoshimura S, Anderson R, Carpanini S, Aligianis I, et al. Rab18 and a Rab18 GEF complex are required for normal ER structure. J Cell Biol. 2014;205:707-20 pubmed publisher
    The ancestral Rab GTPase Rab18 and both subunits of the Rab3GAP complex are mutated in the human neurological and developmental disorder Warburg Micro syndrome...
  51. Pereira Leal J, Strom M, Godfrey R, Seabra M. Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface. Biochem Biophys Res Commun. 2003;301:92-7 pubmed
    ..These results support the hypothesis that Rabs bind REP via conserved RabF motifs and provide a molecular explanation for the preferential recognition of the GDP-bound conformation of Rab by REP. ..
  52. Schafer U, Seibold S, Schneider A, Neugebauer E. Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine. FEBS Lett. 2000;466:148-54 pubmed
    Here we report the isolation of a cDNA encoding the complete human rab18 protein from histamine-stimulated endothelial cells using differential display...
  53. Liu Q, Tang H, Liu X, Liao Y, Li H, Zhao Z, et al. miR-200b as a prognostic factor targets multiple members of RAB family in glioma. Med Oncol. 2014;31:859 pubmed publisher
    ..And its downexpression was correlated with poor prognosis in gliomas. Members of RAB family, RAB21, RAB23, RAB18 and RAB3B were predicted to be novel targets of miR-200b...
  54. Ohsaki Y, Maeda T, Maeda M, Tauchi Sato K, Fujimoto T. Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft. Biochem Biophys Res Commun. 2006;347:279-87 pubmed
    ..Consistent with this, overexpression of Rab18 decreased ADRP, but not TIP47, from LDs, and TIP47 did not displace pre-existing ADRP from LDs...
  55. Dou T, Ji C, Gu S, Chen F, Xu J, Ye X, et al. Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18). DNA Seq. 2005;16:230-4 pubmed
    ..To date, 60 distinct human RAB proteins have been identified. RAB18 gene is discovered from endothelial cells. Its function is considered as endosomes and plasma membrane recycling...
  56. You X, Liu F, Zhang T, Li Y, Ye L, Zhang X. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis. 2013;34:1644-52 pubmed publisher
    ..In this study, we report that the oncogene Rab18, a member of Ras family, enhances the HBx-induced hepatocarcinogenesis through inducing dysregulation of ..
  57. Vazquez Martinez R, Martinez Fuentes A, Pulido M, Jimenez Reina L, Quintero A, Leal Cerro A, et al. Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. J Clin Endocrinol Metab. 2008;93:2269-76 pubmed publisher
    ..Herein we investigated the role of Rab18, which negatively regulates hormone secretion by interacting with secretory granules, in relation to the altered ..
  58. Dansako H, Hiramoto H, Ikeda M, Wakita T, Kato N. Rab18 is required for viral assembly of hepatitis C virus through trafficking of the core protein to lipid droplets. Virology. 2014;462-463:166-74 pubmed publisher
    ..Here, we demonstrated that one of the Ras-related small GTPases, Rab18, was required for trafficking of the core protein around LDs...
  59. Tang W, Lin R, Liao C, Lin Y. Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication. J Virol. 2014;88:6793-804 pubmed publisher
    ..The Rab18 protein, a member of the Rab GTPase family, key regulators of membrane trafficking, is located on the organelles ..
  60. Cheng C, Yang A, Huang C, Liu M, Liou Y, Wu J, et al. The association of RAB18 gene polymorphism (rs3765133) with cerebellar volume in healthy adults. Cerebellum. 2014;13:616-22 pubmed publisher
    ..Loss-of-function mutations in the RAB18 gene (RAB18) cause Warburg Micro syndrome, which is associated with reduced brain size and deformed brain ..
  61. Nisa Z, Mallano A, Yu Y, Chen C, Duan X, Amanullah S, et al. GsSNAP33, a novel Glycine soja SNAP25-type protein gene: Improvement of plant salt and drought tolerances in transgenic Arabidopsis thaliana. Plant Physiol Biochem. 2017;119:9-20 pubmed publisher
    ..and up-regulated expression levels of various stress-responsive marker genes, including KINI, COR15A, P5Cs, RAB18, RD29A and COR47 in transgenic lines compared with those in WT lines...
  62. Li C, Luo X, Zhao S, Siu G, Liang Y, Chan H, et al. COPI-TRAPPII activates Rab18 and regulates its lipid droplet association. EMBO J. 2017;36:441-457 pubmed publisher
    ..We found that mammalian TRAPPII was a GEF for both Rab18 and Rab1...
  63. Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, et al. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. Int J Cancer. 2003;106:244-51 pubmed
    ..by 3 novel genes, genes of unknown function (KIAA0445, KIAA1853, KIAA0665, FLJ13942, HSPC213), a proto-oncogene (rab18), candidate tumor suppressor genes (BAP1, PRDM13) and genes encoding a motor protein (kinesin-2), a histone (H2A1...