Gene Symbol: RAB11FIP5
Description: RAB11 family interacting protein 5
Alias: GAF1, RIP11, pp75, rab11 family-interacting protein 5, RAB11 family interacting protein 5 (class I), gaf-1, gamma-SNAP-associated factor 1, phosphoprotein pp75, rab11-FIP5, rab11-interacting protein Rip11
Species: human
Products:     RAB11FIP5

Top Publications

  1. Oehlke O, Martin H, Osterberg N, Roussa E. Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. J Cell Physiol. 2011;226:638-51 pubmed publisher
    ..Loss-of-function experiments using specific siRNA either against Rab11b or against its effector Rip11 prevent acidosis-induced V-ATPase translocation...
  2. Prekeris R, Klumperman J, Scheller R. A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Mol Cell. 2000;6:1437-48 pubmed
    ..We report the identification of a novel Rab11 effector, Rip11. Rip11 is enriched in polarized epithelial cells where, like Rab11, it is localized to subapical recycling ..
  3. Kelly E, Horgan C, Adams C, Patzer T, Ní Shúilleabháin D, Norman J, et al. Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. Biol Cell. 2009;102:51-62 pubmed publisher
    ..This protein family has been sub-classified into two groups - class I FIPs [FIP2, RCP (Rab coupling protein) and Rip11 (Rab11-interacting protein)] and class II FIPs (FIP3 and FIP4)...
  4. Schonteich E, Wilson G, Burden J, Hopkins C, Anderson K, Goldenring J, et al. The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling. J Cell Sci. 2008;121:3824-33 pubmed publisher
    ..These pathways are regulated by various Rab GTPases, such as Rab4 and Rab11. Here we characterize the role of Rip11/FIP5, a known Rab11-binding protein, in regulating endocytic recycling...
  5. Hales C, Griner R, Hobdy Henderson K, Dorn M, Hardy D, Kumar R, et al. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem. 2001;276:39067-75 pubmed publisher
    ..Rab11-Family Interacting Protein 2 (Rab11-FIP2), Rab11-Family Interacting Protein 3 (Rab11-FIP3), and pp75/Rip11. All four interacting proteins associated with wild type Rab11a and dominant active Rab11a (Rab11aS20V) as well as ..
  6. Bradley T, Peppa D, Pedroza Pacheco I, Li D, Cain D, Henao R, et al. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Cell. 2018;175:387-399.e17 pubmed publisher
    ..who made bnAbs and 46 HIV-1-infected individuals who did not and identified in bnAb individuals upregulation of RAB11FIP5, encoding a Rab effector protein associated with recycling endosomes...
  7. Wallkamm V, Rahm K, Schmoll J, Kaufmann L, Brinkmann E, Schunk J, et al. Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants. BMC Biol. 2016;14:55 pubmed publisher
    ..We found that pbk was specifically regulated by Wnt5a and rab11fip5 by Wnt11...
  8. Ma Y, Ma N, Liu Q, Qi Y, Manabe R, Furuyashiki T. Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast. PLoS ONE. 2015;10:e0144677 pubmed publisher
    ..the GATAAG motifs in isp5+ promoter was critical for its transcriptional activity, and a GATA transcription factor Gaf1 was critical for the activities of isp5+ promoter and the GATAAG reporter...
  9. Boal F, Hodgson L, Reed S, Yarwood S, Just V, Stephens D, et al. Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event. Cell Signal. 2016;28:74-82 pubmed publisher
    b>Rip11 is a Rab11 effector protein that has been shown to be important in controlling the trafficking of several intracellular cargoes, including the fatty acid transporter FAT/CD36, V-ATPase and the glucose transporter GLUT4...

More Information


  1. Laor D, Cohen A, Kupiec M, Weisman R. TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1. MBio. 2015;6:e00959 pubmed publisher
    ..Here we report the identification of the GATA transcription factor Gaf1 as a positive regulator of the nitrogen stress-induced gene isp7(+), via three canonical GATA motifs...
  2. Bacaj T, Ahmad M, Jurado S, Malenka R, Südhof T. Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression. J Neurosci. 2015;35:7460-74 pubmed publisher
    ..To explore the synaptic function of Rab11Fip5, a neuronal Rab11 effector and a candidate autism-spectrum disorder gene, we performed shRNA-mediated knock-down ..
  3. Moreira N, Vitoriano Souza J, Roatt B, Vieira P, Coura Vital W, Cardoso J, et al. Clinical, hematological and biochemical alterations in hamster (Mesocricetus auratus) experimentally infected with Leishmania infantum through different routes of inoculation. Parasit Vectors. 2016;9:181 pubmed publisher
    ..In the current study, hamsters (Mesocricetus auratus) were infected with the L. infantum strains (WHO/MHOM/BR/74/PP75 and MCAN/BR/2008/OP46) by intradermal, intraperitoneal and intracardiac routes...
  4. Laflamme C, Galan J, Ben El Kadhi K, Méant A, Zeledon C, Carreno S, et al. Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis. Mol Cell Biol. 2017;37: pubmed publisher
    ..identified a group of Rab11 effector proteins, termed class I Rab11 family interacting proteins (Rab11-FIPs), or Rip11 in Drosophila We found that 14-3-3 binds to Rip11 in a phospho-dependent manner to ensure its proper subcellular ..
  5. Hwang H, Park G, Park J, Lee H, Lee J, Jeong J, et al. Next Generation Proteomic Pipeline for Chromosome-Based Proteomic Research Using NeXtProt and GENCODE Databases. J Proteome Res. 2017;: pubmed publisher
    ..Four out of 52 GENCODE ASVs such as RAB11FIP5-008 (Chr. 2), RP13-347D8.7-001 (Chr. X), PRDX4-002 (Chr. X), and RP11-666A8.13-001 (Chr...
  6. Fielding A, Schonteich E, Matheson J, Wilson G, Yu X, Hickson G, et al. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 2005;24:3389-99 pubmed
    ..Hence, we propose that FIP3 and FIP4 serve to couple Rab11-positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst. ..
  7. Willenborg C, Jing J, Wu C, Matern H, Schaack J, Burden J, et al. Interaction between FIP5 and SNX18 regulates epithelial lumen formation. J Cell Biol. 2011;195:71-86 pubmed publisher
    ..In summary, the present findings support the hypothesis that this FIP5-SNX18 complex plays a pivotal role in the polarized transport of apical proteins during apical lumen initiation in epithelial cells. ..
  8. Wallace D, Lindsay A, Hendrick A, McCaffrey M. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Biochem Biophys Res Commun. 2002;299:770-9 pubmed
    ..a GTP-dependent manner and that its C-terminal region allows the protein to self-interact and interact with pp75/Rip11, Rab11-FIP2, and Rab11-FIP3...
  9. Fukazawa J, Mori M, Watanabe S, Miyamoto C, Ito T, Takahashi Y. DELLA-GAF1 Complex Is a Main Component in Gibberellin Feedback Regulation of GA20 Oxidase 2. Plant Physiol. 2017;175:1395-1406 pubmed publisher
    ..Previous studies have identified GAI-ASSOCIATED FACTOR1 (GAF1) as such a DELLA interactor, with which DELLAs act as coactivators, and AtGA20ox2 was identified as a target ..
  10. Li D, Mangan A, Cicchini L, Margolis B, Prekeris R. FIP5 phosphorylation during mitosis regulates apical trafficking and lumenogenesis. EMBO Rep. 2014;15:428-37 pubmed publisher
    ..Importantly, we show that FIP5-T276 phosphorylation occurs specifically during metaphase and anaphase, to ensure the fidelity and timing of FIP5-endosome targeting to the AMIS during apical lumen formation. ..
  11. Chen D, Xu W, He P, Medrano E, Whiteheart S. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. J Biol Chem. 2001;276:13127-35 pubmed
    ..These data identify a class of gamma-SNAP interactions that is distinct from other members of the SNAP family and point to a potential role for gamma-SNAP in mitochondrial dynamics. ..
  12. Prekeris R, Davies J, Scheller R. Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem. 2001;276:38966-70 pubmed
    ..20-amino acid domain that is present at the C terminus of Eferin and other Rab11/25-interacting proteins, such as Rip11 and nRip11...
  13. Roohi J, Tegay D, Pomeroy J, Burkett S, Stone G, Stanyon R, et al. A de novo apparently balanced translocation [46,XY,t(2;9)(p13;p24)] interrupting RAB11FIP5 identifies a potential candidate gene for autism spectrum disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:411-7 pubmed publisher
    ..Molecular characterization of the rearrangement revealed direct interruption of the RAB11 family interacting protein 5 (RAB11FIP5) gene...
  14. Cullis D, Philip B, Baleja J, Feig L. Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. J Biol Chem. 2002;277:49158-66 pubmed
    ..These findings suggest that Rab11-FIP2 may participate in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes. ..
  15. Lall P, Horgan C, Oda S, Franklin E, Sultana A, Hanscom S, et al. Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase. Biochim Biophys Acta. 2013;1834:2679-90 pubmed publisher
    ..These cellular, structural and thermodynamic studies provide insight into the Rab11/Rab25 subfamily of small GTPases that regulate endosomal trafficking pathways in eukaryotes. ..
  16. Carson B, Del Bas J, Moreno Navarrete J, Fernandez Real J, Mora S. The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion. PLoS ONE. 2013;8:e74687 pubmed publisher
    ..In contrast, FIP1 expression increased upon exposure of adipocytes to TNFα. In all, our findings identify FIP1 as a novel protein involved in the regulation of adiponectin trafficking and release. ..
  17. Schwenk R, Luiken J, Eckel J. FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells. Biochem Biophys Res Commun. 2007;363:119-25 pubmed
    ..functional role of Rab11a in vesicle movement we knocked down gene expression of Rab11a and two of its effectors, Rip11 and FIP2, in H9c2-hIR cells and measured the cell surface abundance of GLUT4myc and FAT/CD36...
  18. Kawase K, Shibata M, Kawashima H, Hatsuzawa K, Nagahama M, Tagaya M, et al. Gaf-1b is an alternative splice variant of Gaf-1/Rip11. Biochem Biophys Res Commun. 2003;303:1042-6 pubmed
    Gaf-1/Rip11 encoded by the clone KIAA0857 participates in endosomal recycling through the interaction with both gamma-SNAP, a member of the soluble NSF attachment protein family, and a small GTPase, Rab11...
  19. Tani K, Shibata M, Kawase K, Kawashima H, Hatsuzawa K, Nagahama M, et al. Mapping of functional domains of gamma-SNAP. J Biol Chem. 2003;278:13531-8 pubmed
    ..Our two-hybrid analysis revealed that gamma-SNAP, unlike alpha-SNAP, interacts directly with NSF, as well as Gaf-1/Rip11, but not with SNAREs...
  20. Mitchell J, Chesi A, Cousminer D, McCormack S, Kalkwarf H, Lappe J, et al. Multi-dimensional bone density phenotyping reveals new insights in to genetic regulation of the pediatric skeleton. J Bone Miner Res. 2017;: pubmed publisher
    ..5?×?10-11 ) and near RAB11FIP5 (rs58649746, P?=?4.8?×?10-9 ) that associated with PC3...
  21. Wang D, Buyon J, Zhu W, Chan E. Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies. J Clin Invest. 1999;104:1265-75 pubmed
    ..By yeast 2-hybrid screening, we identified a novel 75-kDa protein (pp75) that interacts with the carboxyl 70% of 60-kDa SS-A/Ro...
  22. Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, et al. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 2017;13:e1006603 pubmed publisher
    ..PKA acts early, preventing Rab11 from associating with its effectors Rip11 and Sec15...