Gene Symbol: RAB11FIP4
Description: RAB11 family interacting protein 4
Alias: FIP4-Rab11, RAB11-FIP4, rab11 family-interacting protein 4, RAB11 family interacting protein 4 (class II), arfophilin-2
Species: human
Products:     RAB11FIP4

Top Publications

  1. Wallace D, Lindsay A, Hendrick A, McCaffrey M. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Biochem Biophys Res Commun. 2002;299:770-9 pubmed
    ..It is likely that Rab11-FIP4 serves as a Rab11 effector in a Rab11 mediated function other than transferrin recycling. ..
  2. Wilson G, Fielding A, Simon G, Yu X, Andrews P, Hames R, et al. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol Biol Cell. 2005;16:849-60 pubmed
    ..We propose that the dynamic Rab11-FIP3 interaction controls the delivery, targeting, and fusion of recycling endosomes with furrow during late cytokinesis and abscission. ..
  3. Fielding A, Schonteich E, Matheson J, Wilson G, Yu X, Hickson G, et al. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 2005;24:3389-99 pubmed
    ..Hence, we propose that FIP3 and FIP4 serve to couple Rab11-positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst. ..
  4. Barrett C, Deboever C, Jepsen K, Saenz C, Carson D, Frazer K. Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy. Proc Natl Acad Sci U S A. 2015;112:E3050-7 pubmed publisher
    ..enriched for oncogenic, stem cell/cancer stem cell, and early development loci--including ETV4, FOXM1, LSR, CD9, RAB11FIP4, and FGFRL1...
  5. Pawar K, Sharbati J, Einspanier R, Sharbati S. Mycobacterium bovis BCG Interferes with miR-3619-5p Control of Cathepsin S in the Process of Autophagy. Front Cell Infect Microbiol. 2016;6:27 pubmed publisher
    ..The lysosomal cysteine protease Cathepsin S (CTSS) and Rab11 family-interacting protein 4 (RAB11FIP4) were up-regulated and were considered to be connected to lysosomal trafficking and autophagy...
  6. Jenne D, Tinschert S, Stegmann E, Reimann H, Nurnberg P, Horn D, et al. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. Genomics. 2000;66:93-7 pubmed
  7. Horgan C, Hanscom S, Kelly E, McCaffrey M. Tumor susceptibility gene 101 (TSG101) is a novel binding-partner for the class II Rab11-FIPs. PLoS ONE. 2012;7:e32030 pubmed publisher
    ..Together, these data suggest functional overlap between Rab11-controlled processes and components of the ESCRT pathway. ..
  8. He Y, Ye M, Zhou L, Shan Y, Lu G, Zhou Y, et al. High Rab11-FIP4 expression predicts poor prognosis and exhibits tumor promotion in pancreatic cancer. Int J Oncol. 2017;50:396-404 pubmed publisher
    ..Our findings suggest that overexpression of Rab11-FIP4 predicts poor clinical outcomes for pancreatic cancer and contributes to pancreatic tumor progression. ..
  9. Jenne D, Tinschert S, Dorschner M, Hameister H, Stephens K, Kehrer Sawatzki H. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Genes Chromosomes Cancer. 2003;37:111-20 pubmed

More Information


  1. Jenne D, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, et al. Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. Am J Hum Genet. 2001;69:516-27 pubmed
  2. Hu F, Deng X, Yang X, Jin H, Gu D, Lv X, et al. Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma. Oncogene. 2015;34:6007-17 pubmed publisher
    ..In conclusion, Rab11-FIP4 is a target gene of HIF-1α and has a pro-metastatic role in HCC, suggesting that Rab11-FIP4 may be a promising candidate target for HCC treatment. ..
  3. Hales C, Griner R, Hobdy Henderson K, Dorn M, Hardy D, Kumar R, et al. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem. 2001;276:39067-75 pubmed publisher
    ..The results suggest that the function of Rab11a in plasma membrane recycling systems is dependent upon a compendium of protein effectors...
  4. Shiba T, Koga H, Shin H, Kawasaki M, Kato R, Nakayama K, et al. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. Proc Natl Acad Sci U S A. 2006;103:15416-21 pubmed
    ..The bivalent interaction of FIP3 with Rab11 at the C terminus allows FIP3 to coordinately function with other binding partners, including ARFs. ..
  5. Douglas J, Cilliers D, Coleman K, Tatton Brown K, Barker K, Bernhard B, et al. Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. Nat Genet. 2007;39:963-5 pubmed
    ..These data identify RNF135 as causative of a new overgrowth syndrome and demonstrate that RNF135 haploinsufficiency contributes to the phenotype of NF1 microdeletion cases. ..
  6. Makyio H, Ohgi M, Takei T, Takahashi S, Takatsu H, Katoh Y, et al. Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. EMBO J. 2012;31:2590-603 pubmed publisher
    ..A model based on these results suggests that the Arf6-MKLP1 complex plays a crucial role in cytokinesis by connecting the microtubule bundle and membranes at the cleavage plane. ..