Gene Symbol: RAB11B
Description: RAB11B, member RAS oncogene family
Alias: H-YPT3, NDAGSCW, ras-related protein Rab-11B, GTP-binding protein YPT3, RAB11B, member of RAS oncogene family
Species: human
Products:     RAB11B

Top Publications

  1. Best J, Foell J, Buss C, Delisle B, Balijepalli R, January C, et al. Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels. Am J Physiol Cell Physiol. 2011;300:C1023-33 pubmed publisher
    ..The purpose of the current study was to determine whether the small GTPase Rab11b, a known regulator of endosomal recycling, impacts plasmalemmal expression of Ca(v)1.2 LTCCs...
  2. Roland J, Kenworthy A, Peranen J, Caplan S, Goldenring J. Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. Mol Biol Cell. 2007;18:2828-37 pubmed
    ..Additionally, dynamic live cell imaging demonstrates distinct pathways for Rab11a and Rab8a vesicle trafficking. These findings indicate that Rab8a and Rab11a define different recycling pathways that both use Myosin Vb. ..
  3. Zulkefli K, Houghton F, Gosavi P, Gleeson P. A role for Rab11 in the homeostasis of the endosome-lysosomal pathway. Exp Cell Res. 2019;: pubmed publisher
    ..Here, we have generated HeLa cell lines devoid of either Rab11a or Rab11b using CRISPR/Cas9 to functionally dissect the roles of these two Rab11 family members in recycling and in the ..
  4. Zhu F, Cui Q, Yang Y, Hao J, Yang F, Hou Z. Genome-wide association study of the level of blood components in Pekin ducks. Genomics. 2019;: pubmed publisher
    ..In addition, for serum calcium, one genome-wide significant QTL was identified in the upstream region of gene RAB11B. These results provide new markers for functional studies in Pekin ducks, and several candidate genes were ..
  5. Dorval G, Kuzmuk V, Gribouval O, Welsh G, Bierzynska A, Schmitt A, et al. TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways. Am J Hum Genet. 2019;104:348-355 pubmed publisher
    ..We also showed an interaction between TBC1D8B and Rab11b, a key protein in vesicular recycling in cells...
  6. Kanagaraj P, Gautier Stein A, Riedel D, Schomburg C, Cerdà J, Vollack N, et al. Souffle/Spastizin controls secretory vesicle maturation during zebrafish oogenesis. PLoS Genet. 2014;10:e1004449 pubmed publisher
    ..We show that in zebrafish oocytes suf mutants accumulate Rab11b-positive vesicles, but trafficking of recycling endosomes is not affected...
  7. Gallo L, Liao Y, Ruiz W, Clayton D, Li M, Liu Y, et al. TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Mol Biol Cell. 2014;25:3779-97 pubmed publisher
    ..5 mM), TBC1D9B interacted via its Tre2-Bub2-Cdc16 (TBC) domain with Rab11a, Rab11b, and Rab4a in a nucleotide-dependent manner...
  8. Duman J, Tyagarajan K, Kolsi M, Moore H, Forte J. Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. Am J Physiol. 1999;277:C361-72 pubmed publisher
    ..three forms on rabbit gastric microsomes: the two most prominent resemble rab11a, whereas the third resembles rab11b. Using an adenoviral expression system, we expressed the dominant negative mutant rab11a N124I in primary cultures ..
  9. Lian Y, Xiong F, Yang L, Bo H, Gong Z, Wang Y, et al. Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway. J Exp Clin Cancer Res. 2018;37:253 pubmed publisher
    ..These interactions can mediate the expression of RAB11B, LASP1, and FOSL2 and accelerate cell migration and invasion via the Rho/Rac signaling pathway or FOSL2...

More Information


  1. Udayar V, Buggia Prévot V, Guerreiro R, Siegel G, Rambabu N, Soohoo A, et al. A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production. Cell Rep. 2013;5:1536-51 pubmed publisher
    ..a significant genetic association of Rab11A with late-onset AD, and network analysis identified Rab11A and Rab11B as components of the late-onset AD risk network, suggesting a causal link between Rab11 and AD...
  2. Yeung V, Webber J, Dunlop E, Morgan H, Hutton J, Gurney M, et al. Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma. Nanoscale. 2018;10:8547-8559 pubmed publisher
    ..We highlight that RAB11B and RAB35 regulate phenotypically distinct nanovesicle populations, each accounting for only around 20% of the ..
  3. Shimura M, Mizuma M, Takadate T, Katoh Y, Suzuki T, Iseki M, et al. A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis. Oncotarget. 2018;9:24291-24303 pubmed publisher
    ..We focused on ANXA6, CNPY2, RAB11B and TUBB3, all of which had higher expressions in LT...
  4. Ying G, Gerstner C, Frederick J, Boye S, Hauswirth W, Baehr W. Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors. PLoS ONE. 2016;11:e0161236 pubmed publisher
    ..Absence of phenotype after expression of four dn Rab GTPases in a Rab8a-/- retina suggests that Rab8b and Rab11b paralogs maybe dispensable as well...
  5. Connor M, Pulsifer A, CHUNG D, Rouchka E, Ceresa B, Lawrenz M. Yersinia pestis Targets the Host Endosome Recycling Pathway during the Biogenesis of the Yersinia-Containing Vacuole To Avoid Killing by Macrophages. MBio. 2018;9: pubmed publisher
    ..Moreover, we demonstrated that Y. pestis actively recruits Rab4a and Rab11b to the YCV in a type three secretion system-independent manner, indicating remodeling of the YCV by Y...
  6. Silva J, Martins N, Henriques R, Soares H. HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse. J Immunol. 2016;197:4042-4052 pubmed
    ..messenger Ca2+ We found that HIV-1 Nef specifically associates with the traffic regulators MAL and Rab11b compelling the vesicular accumulation of Lck...
  7. Schlick B, Massoner P, Lueking A, Charoentong P, Blattner M, Schaefer G, et al. Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients. PLoS ONE. 2016;11:e0147739 pubmed publisher
    ..Three autoantibodies were significantly upregulated in both screens, MUT, RAB11B and CSRP2 (p>0.05), two, SPOP and ZNF671, close to statistical significance (p = 0.051 and 0.076)...
  8. Mana G, Clapero F, Panieri E, Panero V, Böttcher R, Tseng H, et al. PPFIA1 drives active ?5?1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nat Commun. 2016;7:13546 pubmed publisher
    ..We identify a pathway, comprising the regulators of post-Golgi carrier formation PI4KB and AP-1A, the small GTPase Rab11B, the surface tyrosine phosphatase receptor PTPRF and its adaptor PPFIA1, which we propose acts as a funnel ..
  9. Appelbaum T, Becker D, Santana E, Aguirre G. Molecular studies of phenotype variation in canine RPGR-XLPRA1. Mol Vis. 2016;22:319-31 pubmed
    ..spanning the entire RPGR interacting and protein trafficking genes (RAB8A, RPGRIP1L, CEP290, CC2D2A, DFNB31, and RAB11B) were genotyped in the pedigree...
  10. Agop Nersesian C, Egarter S, Langsley G, Foth B, Ferguson D, Meissner M. Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B. PLoS Pathog. 2010;6:e1001029 pubmed publisher
    ..factor is involved in the specific transport of vesicles from the Golgi to the IMC and identified the small GTPase Rab11B as an alveolate specific Rab-GTPase that localises to the growing end of the IMC during replication of Toxoplasma ..
  11. Seto S, Tsujimura K, Koide Y. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic. 2011;12:407-20 pubmed publisher
    ..tb-containing phagosomes is involved in arresting phagosome maturation and inhibiting phagolysosome biogenesis. ..
  12. Grimsey N, Coronel L, Cordova I, Trejo J. Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. J Biol Chem. 2016;291:2223-36 pubmed publisher
    ..In addition to known mediators of PAR1 endocytosis, we identified Rab11B as a critical regulator of PAR1 trafficking...
  13. Longatti A, Lamb C, Razi M, Yoshimura S, Barr F, Tooze S. TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J Cell Biol. 2012;197:659-75 pubmed publisher
    ..Thus, TBC1D14- and Rab11-dependent vesicular transport from REs contributes to and regulates starvation-induced autophagy. ..
  14. Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015;11:e1005503 pubmed publisher
    ..These effects are strengthened by the R1441G ROC domain-mutant of LRRK2. These findings suggest that the alteration of Notch signaling in mature neurons is a component of PD etiology linked to LRRK2. ..
  15. Silvis M, Bertrand C, Ameen N, Golin Bisello F, Butterworth M, Frizzell R, et al. Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells. Mol Biol Cell. 2009;20:2337-50 pubmed publisher
    ..Western blotting of immunoisolated Rab11a or Rab11b vesicles revealed localization of endogenous CFTR within both compartments...
  16. Khvotchev M, Ren M, Takamori S, Jahn R, Sudhof T. Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. J Neurosci. 2003;23:10531-9 pubmed
    ..b>Rab11b, which is enriched in brain, had the strongest effect...
  17. Roussa E, Speer J, Chudotvorova I, Khakipoor S, Smirnov S, Rivera C, et al. The membrane trafficking and functionality of the K+-Cl- co-transporter KCC2 is regulated by TGF-?2. J Cell Sci. 2016;129:3485-98 pubmed publisher
    ..pathway from TGF-?2 to cAMP-response-element-binding protein (CREB) and Ras-associated binding protein 11b (Rab11b) as the underlying mechanism for TGF-?2-mediated KCC2 trafficking and functional activation...
  18. Oehlke O, Schlosshardt C, Feuerstein M, Roussa E. Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression. Int J Biochem Cell Biol. 2012;44:1254-65 pubmed publisher
    ..activation of PKA caused phosphorylation of cAMP response element-binding (CREB) and activation to regulate Rab11b transcription...
  19. Hales C, Griner R, Hobdy Henderson K, Dorn M, Hardy D, Kumar R, et al. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem. 2001;276:39067-75 pubmed publisher
    ..All four interacting proteins associated with wild type Rab11a and dominant active Rab11a (Rab11aS20V) as well as Rab11b and Rab25. Rab11-FIP2 also interacted with dominant negative Rab11a (Rab11aS25N) and the tail of myosin Vb...
  20. Zhao Z, Sagare A, Ma Q, Halliday M, Kong P, Kisler K, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015;18:978-87 pubmed publisher
    ..Thus, PICALM regulates Aβ BBB transcytosis and clearance, which has implications for Aβ brain homeostasis and clearance therapy. ..
  21. Matsuzaki F, Shirane M, Matsumoto M, Nakayama K. Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Mol Biol Cell. 2011;22:4602-20 pubmed publisher
    ..Given that mutation of protrudin or KIF5 is a cause of human hereditary spastic paraplegia, the protrudin-KIF5 axis appears to be integral to neuronal function. ..
  22. Yu L, Li X, Li H, Chen H, Liu H. Rab11a sustains GSK3?/Wnt/?-catenin signaling to enhance cancer progression in pancreatic cancer. Tumour Biol. 2016;37:13821-13829 pubmed
    ..In conclusion, the present study demonstrated that Rab11a promotes aggressiveness of pancreatic cancer through GSK3?/Wnt/?-catenin signaling pathway. ..
  23. Gomi H, Osawa H, Uno R, Yasui T, Hosaka M, Torii S, et al. Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties. J Histochem Cytochem. 2017;65:637-653 pubmed publisher
    ..Similarly, Rab proteins (Rab3d, Rab11a, Rab11b, Rab27a, and Rab27b) and soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) ..
  24. Zhu A, Zhao Y, Flier J. Molecular cloning of two small GTP-binding proteins from human skeletal muscle. Biochem Biophys Res Commun. 1994;205:1875-82 pubmed
    ..Northern blot analysis shows that both genes are ubiquitously expressed. Using a bacterial expression vector, each clone was overexpressed in Escherichia coli. The two bacterially produced proteins possess GTP-binding activity. ..
  25. Lall P, Horgan C, Oda S, Franklin E, Sultana A, Hanscom S, et al. Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase. Biochim Biophys Acta. 2013;1834:2679-90 pubmed publisher
    ..These cellular, structural and thermodynamic studies provide insight into the Rab11/Rab25 subfamily of small GTPases that regulate endosomal trafficking pathways in eukaryotes. ..
  26. Greninger A, Knudsen G, Betegon M, Burlingame A, Derisi J. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. MBio. 2013;4:e00098-13 pubmed publisher
    ..This work informs our knowledge of both the physical interactions of the proteins that help maintain metazoan Golgi structure and how viruses subvert these evolutionarily conserved interactions for their own purposes. ..
  27. Madrid R, Janvier K, Hitchin D, Day J, Coleman S, Noviello C, et al. Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity. J Biol Chem. 2005;280:5032-44 pubmed
  28. Reger A, Yang M, Koide Yoshida S, Guo E, Mehta S, Yuasa K, et al. Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions. J Biol Chem. 2014;289:25393-403 pubmed publisher
    ..the type II PKG leucine zipper domain and found that residues 40-83 dimerized and specifically interacted with Rab11b. Next, we determined a crystal structure of the PKG II LZ-Rab11b complex...
  29. Tarafder A, Bolasco G, Correia M, Pereira F, Iannone L, Hume A, et al. Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis. J Invest Dermatol. 2014;134:1056-1066 pubmed publisher
    ..Furthermore, depletion of Rab11b, but not Rab27a, caused a marked decrease in both keratinocyte-stimulated melanin exocytosis and transfer to ..
  30. Lindsay A, Jollivet F, Horgan C, Khan A, Raposo G, McCaffrey M, et al. Identification and characterization of multiple novel Rab-myosin Va interactions. Mol Biol Cell. 2013;24:3420-34 pubmed publisher
    ..We also present evidence that myosin Va is necessary for maintaining a peripheral distribution of Rab11- and Rab14-positive endosomes. ..
  31. Schlierf B, Fey G, Hauber J, Hocke G, Rosorius O. Rab11b is essential for recycling of transferrin to the plasma membrane. Exp Cell Res. 2000;259:257-65 pubmed
    ..The Rab11 subfamily consists of two highly conserved members, Rab11a and Rab11b. Rab11a has been localized both to the pericentriolar recycling endosome and to the trans-Golgi network and ..
  32. Yi L, Rosales T, Rose J, Chowdhury B, Chaudhury B, Knutson J, et al. HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking. J Biol Chem. 2010;285:30884-905 pubmed publisher
    ..In all, our data support a model for Nef down-regulation of HLA-I that involves both major trafficking itineraries and persistent protein-protein interactions throughout the cell...
  33. Lapierre L, Kumar R, Hales C, Navarre J, Bhartur S, Burnette J, et al. Myosin vb is associated with plasma membrane recycling systems. Mol Biol Cell. 2001;12:1843-57 pubmed
    ..to the carboxyl terminal 60 kDa of the myosin Vb tail, interacted with all members of the Rab11 family (Rab11a, Rab11b, and Rab25)...
  34. Lapierre L, Goldenring J. Interactions of myosin vb with rab11 family members and cargoes traversing the plasma membrane recycling system. Methods Enzymol. 2005;403:715-23 pubmed
    ..Expression of myosin Vb tail represents a powerful provocative test for the trafficking of cargoes through Rab11-containing plasma membrane recycling systems. ..
  35. Lamers I, Reijnders M, Venselaar H, Kraus A, Jansen S, de Vries B, et al. Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype. Am J Hum Genet. 2017;101:824-832 pubmed publisher
    ..Here, we report five individuals with two recurrent de novo missense mutations in RAB11B; c.64G>A; p.Val22Met in three individuals and c.202G>A; p.Ala68Thr in two individuals...
  36. Haugsten E, Brech A, Liestøl K, Norman J, Wesche J. Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling. Traffic. 2014;15:665-83 pubmed publisher
    ..Upon Rab11b depletion, FGFR4 is trapped in the pericentriolar recycling compartment and the total levels of FGFR4 in cells are ..
  37. Oehlke O, Martin H, Osterberg N, Roussa E. Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. J Cell Physiol. 2011;226:638-51 pubmed publisher
    ..The results show that Rab11b is expressed in salivary ducts and exhibits a significantly higher co-localization with V-ATPase than Rab11a and ..
  38. Prekeris R, Davies J, Scheller R. Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem. 2001;276:38966-70 pubmed
    ..The data suggest that various Rab effectors compete with each other for binding to Rab11/25 possibly accounting for the diversity of Rab11 functions. ..
  39. Chou C, Hwang G, Hageman D, Han L, Agrawal P, Pisitkun T, et al. Identification of UT-A1 and AQP2 interacting proteins in rat inner medullary collecting duct. Am J Physiol Cell Physiol. 2017;:ajpcell.00082.2017 pubmed publisher
    ..Among the proteins unique to the AQP2 list were several Rab proteins (Rab1a, Rab2a, Rab5b, Rab5c, Rab7a, Rab11a, Rab11b, Rab14, Rab17) involved in membrane trafficking...
  40. Scapin S, Carneiro F, Alves A, Medrano F, Guimarães B, Zanchin N. The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform. J Struct Biol. 2006;154:260-8 pubmed
    ..The Rab11 subfamily members, comprising Rab11a, Rab11b, and Rab25, act in recycling of proteins from the endosomes to the plasma membrane, in transport of molecules from ..