Gene Symbol: Rab11
Description: RAB11A, member RAS oncogene family
Alias: YL8, ras-related protein Rab-11A, RAB 11A, member oncogene family, rab-11
Species: human
Products:     Rab11

Top Publications

  1. Fielding A, Schonteich E, Matheson J, Wilson G, Yu X, Hickson G, et al. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 2005;24:3389-99 pubmed
    The dual Rab11/Arf binding proteins, family of Rab11-interacting proteins FIP3 and FIP4 function in the delivery of recycling endosomes to the cleavage furrow and are, together with Rab11, essential for completion of abscission, the ..
  2. Nedvetsky P, Stefan E, Frische S, Santamaria K, Wiesner B, Valenti G, et al. A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic. 2007;8:110-23 pubmed
    ..line CD8, and primary principal cells, we studied the role of the motor protein myosin Vb, its vesicular receptor Rab11, and the myosin Vb- and Rab11-binding protein Rab11-FIP2 in the AQP2 shuttle...
  3. Junutula J, Schonteich E, Wilson G, Peden A, Scheller R, Prekeris R. Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. J Biol Chem. 2004;279:33430-7 pubmed
    The Rab11 subfamily of GTPases plays an important role in vesicle trafficking from endosomes to the plasma membrane...
  4. Westlake C, Junutula J, Simon G, Pilli M, Prekeris R, Scheller R, et al. Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. Proc Natl Acad Sci U S A. 2007;104:1236-41 pubmed
    ..Here we describe the identification of Evi5 as a candidate binding protein for Rab11, a GTPase that regulates intracellular transport and has specific roles in endosome recycling and cytokinesis...
  5. Roland J, Kenworthy A, Peranen J, Caplan S, Goldenring J. Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. Mol Biol Cell. 2007;18:2828-37 pubmed
    ..can cause the accumulation of both Rab11a and Rab8a in collapsed membrane cisternae, whereas dominant-negative Rab11-FIP2(129-512) selectively accumulates Rab11a but not Rab8a...
  6. Knödler A, Feng S, Zhang J, Zhang X, Das A, Peranen J, et al. Coordination of Rab8 and Rab11 in primary ciliogenesis. Proc Natl Acad Sci U S A. 2010;107:6346-51 pubmed publisher
    ..Here we report that Rabin8 is a direct downstream effector of Rab11, which functions in membrane trafficking from the trans-Golgi network and recycling endosomes...
  7. Takahashi S, Kubo K, Waguri S, Yabashi A, Shin H, Katoh Y, et al. Rab11 regulates exocytosis of recycling vesicles at the plasma membrane. J Cell Sci. 2012;125:4049-57 pubmed publisher
    b>Rab11 is known to associate primarily with perinuclear recycling endosomes and regulate recycling of endocytosed proteins. However, the recycling step in which Rab11 participates remains unknown...
  8. Hales C, Griner R, Hobdy Henderson K, Dorn M, Hardy D, Kumar R, et al. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem. 2001;276:39067-75 pubmed publisher
    ..Here we define a family of four Rab11-interacting proteins: Rab11-Family Interacting Protein 1 (Rab11-FIP1), Rab11-Family Interacting Protein 2 (Rab11-..
  9. Lindsay A, McCaffrey M. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. FEBS Lett. 2004;571:86-92 pubmed
    Rab coupling protein (RCP) is a member of the Rab11-family of interacting proteins (Rab11-FIPs). Family members are characterised by their ability to interact with Rab11...

More Information

Publications143 found, 100 shown here

  1. Wallace D, Lindsay A, Hendrick A, McCaffrey M. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Biochem Biophys Res Commun. 2002;299:770-9 pubmed
    We have recently identified Rab11-FIP4 as the sixth member of the Rab11-FIP family of Rab11 interacting proteins...
  2. Pohl C, Jentsch S. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. Cell. 2008;132:832-45 pubmed publisher
    ..We propose that BRUCE coordinates multiple steps required for abscission and that ubiquitylation may be a crucial trigger. ..
  3. Yu X, Prekeris R, Gould G. Role of endosomal Rab GTPases in cytokinesis. Eur J Cell Biol. 2007;86:25-35 pubmed
    Completion of cytokinesis requires Rab 11-dependent membrane trafficking events to deliver new membrane to the furrow and for abscission...
  4. Lapierre L, Kumar R, Hales C, Navarre J, Bhartur S, Burnette J, et al. Myosin vb is associated with plasma membrane recycling systems. Mol Biol Cell. 2001;12:1843-57 pubmed
    ..clone, corresponding to the carboxyl terminal 60 kDa of the myosin Vb tail, interacted with all members of the Rab11 family (Rab11a, Rab11b, and Rab25)...
  5. Wikström K, Reid H, Hill M, English K, O Keeffe M, Kimbembe C, et al. Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase. Cell Signal. 2008;20:2332-46 pubmed publisher
    ..The hIP co-localized to Rab11-containing recycling endosomes in both HEK293 and endothelial EA...
  6. Gidon A, Bardin S, Cinquin B, Boulanger J, Waharte F, Heliot L, et al. A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane. Traffic. 2012;13:815-33 pubmed publisher
    ..Rab11A dependent recycling pathway, in the context of the membrane platform constituted by Myosin Vb, Rab11A, and Rab11-FIP2...
  7. Lindsay A, McCaffrey M. Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. J Biol Chem. 2002;277:27193-9 pubmed
    b>Rab11-FIP2 is a recently described member of the Rip11/Rab11-FIP/Rab coupling protein family of Rab11 interacting proteins...
  8. Shirane M, Nakayama K. Protrudin induces neurite formation by directional membrane trafficking. Science. 2006;314:818-21 pubmed
    Guanosine triphosphatases of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling...
  9. Peden A, Schonteich E, Chun J, Junutula J, Scheller R, Prekeris R. The RCP-Rab11 complex regulates endocytic protein sorting. Mol Biol Cell. 2004;15:3530-41 pubmed
    b>Rab 11 GTPase is an important regulator of endocytic membrane traffic. Recently, we and others have identified a novel family of Rab11 binding proteins, known as Rab11-family interacting proteins (FIPs)...
  10. Wilson G, Fielding A, Simon G, Yu X, Andrews P, Hames R, et al. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol Biol Cell. 2005;16:849-60 pubmed
    ..First, we show that Rab11- and FIP3-containing recycling endosomes accumulate near the cleavage furrow and are required for successful ..
  11. Jagoe W, Lindsay A, Read R, McCoy A, McCaffrey M, Khan A. Crystal structure of rab11 in complex with rab11 family interacting protein 2. Structure. 2006;14:1273-83 pubmed
    The small GTPase Rab11 regulates the recycling of endosomes to the plasma membrane via interactions with the Rab11 family of interacting proteins (FIPs)...
  12. Horgan C, Hanscom S, Jolly R, Futter C, McCaffrey M. Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment. J Cell Sci. 2010;123:181-91 pubmed publisher
    Several protein families control intracellular transport processes in eukaryotic cells. Here, we show that the Rab11 GTPase effector protein Rab11-FIP3 (henceforth, FIP3) directly interacts with the dynein light intermediate chain 1 (..
  13. Lindsay A, McCaffrey M. The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. J Cell Sci. 2004;117:4365-75 pubmed
    The Rab11 family of interacting proteins (Rab11-FIP) is a recently identified protein family composed of, to date, six members that interact with Rab11. They all share a highly homologous Rab11-binding domain (RBD) at their C-termini...
  14. Fuchs E, Haas A, Spooner R, Yoshimura S, Lord J, Barr F. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007;177:1133-43 pubmed
    ..These results suggest that Shiga toxin trafficking to the Golgi is a multistep process controlled by several Rab GAPs and their target Rabs and that this process is discrete from ligand-induced EGF receptor trafficking. ..
  15. Chu B, Ge L, Xie C, Zhao Y, Miao H, Wang J, et al. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. J Biol Chem. 2009;284:22481-90 pubmed publisher
    ..the roles of the microfilament and microfilament-associated triple complex composed of myosin Vb, Rab11a, and Rab11-FIP2 in the transport of NPC1L1 from the endocytic recycling compartment to the PM...
  16. Lindsay A, Hendrick A, Cantalupo G, Senic Matuglia F, Goud B, Bucci C, et al. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. J Biol Chem. 2002;277:12190-9 pubmed
    Rab4 and Rab11 are small GTPases belonging to the Ras superfamily. They both function as regulators along the receptor recycling pathway...
  17. Prekeris R, Klumperman J, Scheller R. A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Mol Cell. 2000;6:1437-48 pubmed
    b>Rab11 is a GTPase that regulates endosomal trafficking to apical plasma membrane domains in polarized epithelial cells. We report the identification of a novel Rab11 effector, Rip11...
  18. Westlake C, Baye L, Nachury M, Wright K, Ervin K, Phu L, et al. Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc Natl Acad Sci U S A. 2011;108:2759-64 pubmed publisher
    ..Rab8-dependent ciliary assembly is initiated by the relocalization of Rabin8 to Rab11-positive vesicles that are transported to the centrosome...
  19. Wang L, Kantovitz K, Cullinane A, Nociti F, Foster B, Roney J, et al. Skin fibroblasts from individuals with Chediak-Higashi Syndrome (CHS) exhibit hyposensitive immunogenic response. Orphanet J Rare Dis. 2014;9:212 pubmed publisher
  20. Swiatecka Urban A, Brown A, Moreau Marquis S, Renuka J, Coutermarsh B, Barnaby R, et al. The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells. J Biol Chem. 2005;280:36762-72 pubmed
  21. Tome M, Schaefer C, Jacobs L, Zhang Y, Herndon J, Matty F, et al. Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels. J Neurochem. 2015;134:200-10 pubmed publisher
    ..These data suggest signaling pathways with a potential role in post-translational regulation of PgP activity at the BBB. ..
  22. Yu X, Taylor A, Nagai J, GOLSHANI P, Evans C, Coppola G, et al. Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior. Neuron. 2018;99:1170-1187.e9 pubmed publisher
    ..Thus, striatal astrocytes contribute to neuromodulation controlling mouse obsessive-compulsive-like behavior. ..
  23. Boulanger J, Gueudry C, Münch D, Cinquin B, Paul Gilloteaux P, Bardin S, et al. Fast high-resolution 3D total internal reflection fluorescence microscopy by incidence angle scanning and azimuthal averaging. Proc Natl Acad Sci U S A. 2014;111:17164-9 pubmed publisher
    ..We apply this imaging modality to obtain structural and dynamical information about 3D actin architectures. We also temporally decipher distinct Rab11a-dependent exocytosis events in 3D at a rate of seven stacks per second. ..
  24. Gallo L, Liao Y, Ruiz W, Clayton D, Li M, Liu Y, et al. TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Mol Biol Cell. 2014;25:3779-97 pubmed publisher
    ..We conclude that TBC1D9B is a Rab11a GAP that regulates basolateral-to-apical transcytosis in polarized MDCK cells. ..
  25. Simon G, Schonteich E, Wu C, Piekny A, Ekiert D, Yu X, et al. Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. EMBO J. 2008;27:1791-803 pubmed publisher
    ..Thus, we propose that centralspindlin complex not only regulates acto-myosin ring contraction but also endocytic vesicle transport to the cleavage furrow and it does so through sequential interactions with ECT2 and FIP3. ..
  26. Wang H, Wang G, Gao Y, Zhao C, Li X, Zhang F, et al. Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors. Cell Physiol Biochem. 2018;48:1291-1303 pubmed publisher
    ..Our data suggest that lnc-SNHG1 promotes the progression of pituitary tumors and is a potential therapeutic target for invasive pituitary tumor. ..
  27. Li D, Mangan A, Cicchini L, Margolis B, Prekeris R. FIP5 phosphorylation during mitosis regulates apical trafficking and lumenogenesis. EMBO Rep. 2014;15:428-37 pubmed publisher
    ..These changes are accomplished, at least in part, by the targeting and fusion of Rab11/FIP5-containing apical endosomes with the apical membrane initiation site (AMIS)...
  28. Khandelwal P, Ruiz W, Balestreire Hawryluk E, Weisz O, Goldenring J, Apodaca G. Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci U S A. 2008;105:15773-8 pubmed publisher
    ..Our results indicate that DFV may be biosynthetic in nature and that their exocytosis depends on the activity of the Rab11a GTPase. ..
  29. Bannister J, Bulley S, Leo M, Kidd M, Jaggar J. Rab25 influences functional Cav1.2 channel surface expression in arterial smooth muscle cells. Am J Physiol Cell Physiol. 2016;310:C885-93 pubmed publisher
    ..These data indicate that Rab25 is expressed in arterial myocytes where it promotes surface expression of CaV1.2 channels to control pressure- and depolarization-induced vasoconstriction. ..
  30. Lee C, Ko A, Chiang S, Lu C, Tsai E, Ko Y. Regulatory elements in vectors containing the ctEF-1α first intron and double enhancers for an efficient recombinant protein expression system. Sci Rep. 2018;8:15396 pubmed publisher
  31. Savina A, Fader C, Damiani M, Colombo M. Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner. Traffic. 2005;6:131-43 pubmed
    ..increase in cytosolic calcium affects the development of MVBs and exosome release in K562 cells overexpressing GFP-Rab11 wt or its mutants...
  32. Reish N, Boitet E, Bales K, Gross A. Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsin. J Neurosci. 2014;34:14854-63 pubmed publisher
    ..Together, our results show the critical importance of direct rhodopsin-rab11a interactions for the formation and maintenance of vertebrate photoreceptors. ..
  33. Fowler M, McPhail J, Jenkins M, Masson G, Rutaganira F, Shokat K, et al. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Sci. 2016;25:826-39 pubmed publisher
    ..dynamic regions within type III phosphatidylinositol 4 kinase beta (PI4KIIIβ) in complex with the GTPase Rab11. This information was then used to design deletions that allowed for the production of diffraction quality ..
  34. Shisheva A, Chinni S, DeMarco C. General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. Biochemistry. 1999;38:11711-21 pubmed
    ..in structure, localized and operating on different membranes, including Rab2, Rab4, Rab5, Rab8, Rab9, and Rab11. We demonstrate here a general and nearly invariant ability of GDI-2(WT) to release from membranes this subset of ..
  35. Galea G, Bexiga M, Panarella A, O Neill E, Simpson J. A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking. J Cell Sci. 2015;128:2339-49 pubmed publisher
    ..Our approach therefore provides a novel and robust strategy for a more complete investigation of the molecular components required to regulate Golgi-to-ER transport in mammalian cells. ..
  36. Eggers C, Schafer J, Goldenring J, Taylor S. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem. 2009;284:32869-80 pubmed publisher
    ..We show here that these RGS domains interact with Rab11 and GTP-bound Rab4, the first demonstration of RGS domains binding small GTPases...
  37. Eisfeld A, Kawakami E, Watanabe T, Neumann G, Kawaoka Y. RAB11A is essential for transport of the influenza virus genome to the plasma membrane. J Virol. 2011;85:6117-26 pubmed publisher
    ..Here, we reveal a functional relationship between the cellular Rab11 GTPase isoform, RAB11A, and vRNPs and show that RAB11A is indispensable for proper vRNP transport to the plasma ..
  38. Kadiu I, Gendelman H. Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection. J Neuroimmune Pharmacol. 2011;6:658-75 pubmed publisher
    ..clathrin-dependent viral entry, HIV-1 constituents bypass degradation by differential sorting from early to Rab11(+) recycling endosomes and multivesicular bodies...
  39. Kessler D, Gruen G, Heider D, Morgner J, Reis H, Schmid K, et al. The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration. Cell Physiol Biochem. 2012;29:647-56 pubmed publisher
    The closely related GTPases Rab11 and Rab25 promote cell migration by regulating vesicular transport and recycling of surface receptors. Rab25 carries a constitutively activating mutation in its GTPase domain...
  40. Duman J, Tyagarajan K, Kolsi M, Moore H, Forte J. Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. Am J Physiol. 1999;277:C361-72 pubmed publisher
    ..Previous studies have implicated the small GTPase rab11 in this process...
  41. Prekeris R, Davies J, Scheller R. Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem. 2001;276:38966-70 pubmed
    b>Rab11, a low molecular weight GTP-binding protein, has been shown to play a key role in a variety of cellular processes, including endosomal recycling, phagocytosis, and transport of secretory proteins from the trans-Golgi network...
  42. Cullinane A, Straatman Iwanowska A, Zaucker A, Wakabayashi Y, Bruce C, Luo G, et al. Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. Nat Genet. 2010;42:303-12 pubmed publisher
    ..The VPS33B-VIPAR complex thus has diverse functions in the pathways regulating apical-basolateral polarity in the liver and kidney. ..
  43. Morrow A, Alipour M, Bridges D, Yao Z, Saltiel A, Lee J. The lipid kinase PI4KIII? is highly expressed in breast tumors and activates Akt in cooperation with Rab11a. Mol Cancer Res. 2014;12:1492-508 pubmed publisher
    ..Thus, PI4KIII? likely plays a role in breast oncogenesis and that cooperation between Rab11a and PI4KIII? represents a novel Akt activation pathway. ..
  44. Coumailleau F, Das V, Alcover A, Raposo G, Vandormael Pournin S, Le Bras S, et al. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell. 2004;15:4444-56 pubmed
    ..protein, that, when overexpressed in HeLa cells, induced the condensation of transferrin receptor-, Rab5-, and Rab11-positive recycling tubulovesicular membranes in the perinuclear region...
  45. Marshall M, Pattu V, Halimani M, Maier Peuschel M, Müller M, Becherer U, et al. VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity. J Cell Biol. 2015;210:135-51 pubmed publisher
    ..Our findings imply that secretory granule exocytosis pathways in other cell types may also be more complex than previously appreciated. ..
  46. Drivas G, Shih A, Coutavas E, D EUSTACHIO P, Rush M. Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. Oncogene. 1991;6:3-9 pubmed
    ..The one homologous to rab/YPT, referred to here as YL8, appears to be the human homolog of the recently reported Schizosaccharomyces pombe YPT3 gene...
  47. Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015;11:e1005503 pubmed publisher
    ..These effects are strengthened by the R1441G ROC domain-mutant of LRRK2. These findings suggest that the alteration of Notch signaling in mature neurons is a component of PD etiology linked to LRRK2. ..
  48. Ying G, Gerstner C, Frederick J, Boye S, Hauswirth W, Baehr W. Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors. PLoS ONE. 2016;11:e0161236 pubmed publisher
    ..Our data thus demonstrate significant interspecies variation in photoreceptor membrane protein and rhodopsin trafficking. ..
  49. Zhu S, Bhat S, Syan S, Kuchitsu Y, Fukuda M, Zurzolo C. Rab11a-Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling. J Cell Sci. 2018;131: pubmed publisher
    ..We demonstrate that these two Rab GTPases act in a cascade in which Rab11a activation of Rab8a is independent of Rabin8. We also show that VAMP3 acts downstream of Rab8a to regulate TNT formation. ..
  50. Poehler A, Xiang W, Spitzer P, May V, Meixner H, Rockenstein E, et al. Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment. Autophagy. 2014;10:2171-92 pubmed publisher
    ..These findings suggest that the major toxic role of SNCA is related to its extracellular species and further supports a protective role of intracellular SNCA aggregation. ..
  51. Dumanchin C, Czech C, Campion D, Cuif M, Poyot T, Martin C, et al. Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport. Hum Mol Genet. 1999;8:1263-9 pubmed
    ..We report an interaction between the human PS1 or PS2 hydrophilic loop and Rab11, a small GTPase belonging to the Ras-related superfamily...
  52. Amet T, Nonaka M, Dewan M, Saitoh Y, Qi X, Ichinose S, et al. Statin-induced inhibition of HIV-1 release from latently infected U1 cells reveals a critical role for protein prenylation in HIV-1 replication. Microbes Infect. 2008;10:471-80 pubmed publisher
    ..Our findings thus suggest that small GTPase proteins play an important role in HIV-1 replication, and therefore could be attractive molecular targets for anti-HIV-1 therapy. ..
  53. Parmar H, Duncan R. A novel tribasic Golgi export signal directs cargo protein interaction with activated Rab11 and AP-1-dependent Golgi-plasma membrane trafficking. Mol Biol Cell. 2016;27:1320-31 pubmed publisher
    ..and fluorescence resonance energy transfer (FRET) assays, we now show the PBM directs interaction of p14 with GTP-Rab11. Overexpression of dominant-negative Rab11 and RNA interference knockdown of endogenous Rab11 inhibited p14 plasma ..
  54. Watanuki Z, Kosai H, Osanai N, Ogama N, Mochizuki M, Tamai K, et al. Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling. Biochem Biophys Res Commun. 2014;455:269-76 pubmed publisher
    ..Our results suggest that the synergistic effect exerted by afatinib and cetuximab on NSCLCs is associated with BIM induction and alterations in EGFR status. ..
  55. Jiang C, Liu Z, Hu R, Bo L, Minshall R, Malik A, et al. Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils. J Immunol. 2017;198:1660-1672 pubmed publisher
    ..Our results raise the possibility that inhibition of Rab11a activity in macrophages is a promising strategy for activating the resolution of inflammatory lung injury. ..
  56. Parkinson K, Baines A, Keller T, Gruenheit N, Bragg L, North R, et al. Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel. Nat Cell Biol. 2014;16:87-98 pubmed publisher
    ..These findings suggest that P2XA activation results in vacuolar calcium release, which triggers activation of CnrF Rab GAP activity and subsequent downregulation of Rab11a to allow vacuole fusion. ..
  57. Bodrikov V, Pauschert A, Kochlamazashvili G, Stuermer C. Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons. Exp Neurol. 2017;289:31-45 pubmed publisher
  58. Eathiraj S, Mishra A, Prekeris R, Lambright D. Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes. J Mol Biol. 2006;364:121-35 pubmed
    The Rab11 GTPase regulates recycling of internalized plasma membrane receptors and is essential for completion of cytokinesis...
  59. Ohta K, Matsumoto Y, Nishio M. Rab27a facilitates human parainfluenza virus type 2 growth by promoting cell surface transport of envelope proteins. Med Microbiol Immunol. 2018;207:141-150 pubmed publisher
    ..Our results collectively suggest that the active form of Rab27a enhances hPIV-2 growth by promoting transport of F and HN proteins to the plasma membrane. ..
  60. Hsiao J, Chu L, Lo Y, Lee S, Chen T, Huang C, et al. Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22. J Virol. 2015;89:8365-82 pubmed publisher
    ..Our results showed that vaccinia virus traffics to early endosomes, where recycling endosome markers Rab11 and Rab22 are recruited to participate in subsequent virus trafficking prior to virus core uncoating in the ..
  61. Liao Y, Li M, Chen X, Jiang Y, Yin X. Interaction of TBC1D9B with Mammalian ATG8 Homologues Regulates Autophagic Flux. Sci Rep. 2018;8:13496 pubmed publisher
    ..TBC1D9B can thus positively regulate autophagic flux, possibly through its GTPase activity to inactivate RAB11A, facilitating the proper destination of the autophagosomes to the degradation. ..
  62. Sakurada K, Uchida K, Yamaguchi K, Aisaka K, Ito S, Ohmori T, et al. Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver. Biochem Biophys Res Commun. 1991;177:1224-32 pubmed
    ..The sequence analysis of 24KG revealed that a 24KG cDNA is the rat counterpart of a rab11 cDNA cloned from a Madin-Darby canine kidney cell cDNA library. The 1...
  63. Charest Morin X, Fortin S, Lodge R, Roy C, Gera L, Gaudreault R, et al. Inhibitory effects of cytoskeleton disrupting drugs and GDP-locked Rab mutants on bradykinin B? receptor cycling. Pharmacol Res. 2013;71:44-52 pubmed publisher
    ..Dominant negative (GDP-locked)-Rab5 and -Rab11 reproduced the effects of inhibitors of tubulin and actin, respectively, on the cycling of B?R-GFP...
  64. Hogue I, Bosse J, Hu J, Thiberge S, Enquist L. Cellular mechanisms of alpha herpesvirus egress: live cell fluorescence microscopy of pseudorabies virus exocytosis. PLoS Pathog. 2014;10:e1004535 pubmed publisher
  65. Gomi H, Osawa H, Uno R, Yasui T, Hosaka M, Torii S, et al. Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties. J Histochem Cytochem. 2017;65:637-653 pubmed publisher
    ..These results suggest that protein expression profiles in canine salivary glands differ among individual glands and reflect the properties of their specialized functions. ..
  66. Inoshita M, Mima J. Human Rab small GTPase- and class V myosin-mediated membrane tethering in a chemically defined reconstitution system. J Biol Chem. 2017;292:18500-18517 pubmed publisher
    ..They further indicate that Rab-interacting effector proteins, including class V myosins, can regulate these Rab-mediated membrane-tethering reactions. ..
  67. Reyes Ibarra A, García Regalado A, Ramírez Rangel I, Esparza Silva A, Valadez Sánchez M, Vazquez Prado J, et al. Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism. Mol Endocrinol. 2007;21:1394-407 pubmed
    ..Our results indicate that endocytosis and trafficking of CaR modulate PTHrP secretion. ..
  68. Knowles B, Weis V, Yu S, Roland J, Williams J, Alvarado G, et al. Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. J Cell Sci. 2015;128:1617-26 pubmed publisher
    ..Rab11a deficiency in enterocytes altered the apical localization of syntaxin 3. These data affirm the role of Rab11a in apical membrane trafficking and the maintenance of apical microvilli in enterocytes. ..
  69. Vogel G, Klee K, Janecke A, Müller T, Hess M, Huber L. Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3. J Cell Biol. 2015;211:587-604 pubmed publisher
    ..of NHE3, CFTR (cystic fibrosis transmembrane conductance regulator), and GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3, which cooperate in the final steps of this selective apical traffic ..
  70. Pacheco M, Morais K, Berra C, Demasi M, Sciani J, Branco V, et al. Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X. Exp Cell Res. 2016;340:248-58 pubmed publisher
    ..Thereby, the results provide new insights on the antitumor mechanism of Amblyomin-X and reveal an unsuspected role of cytoplasmic dynein in its uptake, intracellular trafficking and pro-apoptotic action. ..
  71. Leo M, Zhai X, Muralidharan P, Kuruvilla K, Bulley S, Boop F, et al. Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction. Sci Signal. 2017;10: pubmed publisher
    ..Thus, membrane depolarization activates BK channels through stimulation of ROCK- and Rab11A-dependent trafficking of β1 subunits to the surface of arterial myocytes. ..
  72. Yi L, Rosales T, Rose J, Chowdhury B, Chaudhury B, Knutson J, et al. HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking. J Biol Chem. 2010;285:30884-905 pubmed publisher
    ..In all, our data support a model for Nef down-regulation of HLA-I that involves both major trafficking itineraries and persistent protein-protein interactions throughout the cell...
  73. Gardner L, Hajjhussein H, Frederick Dyer K, Bahouth S. Rab11a and its binding partners regulate the recycling of the ß1-adrenergic receptor. Cell Signal. 2011;23:46-57 pubmed publisher
    ..In recycling endosomes WT ß1-AR were colocalized by >70% with the rab11 GTPase...
  74. Lee Y, Chung S, Baek I, Lee T, Paik S, Lee J. UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis. Cell Cycle. 2013;12:1303-15 pubmed publisher
    ..family kinases (SFKs) regulate the completion of cytokinesis through signal transduction pathways that lead to the Rab11-dependent phosphorylation of ERK and its localization to the midbody of cytokinetic cells...
  75. Guo D, Zhang G, Wysocki T, Wysocki B, Gelbard H, Liu X, et al. Endosomal trafficking of nanoformulated antiretroviral therapy facilitates drug particle carriage and HIV clearance. J Virol. 2014;88:9504-13 pubmed publisher
    ..The current work uncovers a new mechanism by which nanoART can enhance viral clearance over native drug formulations...
  76. Liu X, Hong Q, Wang Z, Yu Y, Zou X, Xu L. MiR-21 inhibits autophagy by targeting Rab11a in renal ischemia/reperfusion. Exp Cell Res. 2015;338:64-9 pubmed publisher
    ..The results showed that miR-21 inhibited autophagy by targeting Rab11a in renal I/R, indicating that Rab11a might be a new medical target for the treatment of renal I/R. ..
  77. Stone R, Hayashi T, Bajimaya S, Hodges E, Takimoto T. Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses. Virology. 2016;487:11-8 pubmed publisher
    ..In this study, we analyzed the impact of the Rab11-mediated recycling pathway in Sendai virus (SeV) and human parainfluenza virus type 1 (hPIV1) vRNP transport...
  78. Romano J, Nolan S, Porter C, Ehrenman K, Hartman E, Hsia R, et al. The parasite Toxoplasma sequesters diverse Rab host vesicles within an intravacuolar network. J Cell Biol. 2017;216:4235-4254 pubmed publisher
    ..Overexpression of a phospholipase TgLCAT, which is localized to the IVN, results in a decrease in the number of intravacuolar GFP-Rab11A vesicles, suggesting that TgLCAT controls lipolytic degradation of Rab vesicles for cargo release. ..
  79. Thériault C, Rochdi M, Parent J. Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta). Biochemistry. 2004;43:5600-7 pubmed
    ..Receptor cell surface expression and endocytosis experiments further revealed that the small GTPase Rab11 protein is a determinant factor in controlling TPbeta recycling back to the cell surface...
  80. Pisitkun T, Shen R, Knepper M. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A. 2004;101:13368-73 pubmed
    ..The results indicate that exosome isolation may provide an efficient first step in biomarker discovery in urine. ..
  81. Bruce E, Digard P, Stuart A. The Rab11 pathway is required for influenza A virus budding and filament formation. J Virol. 2010;84:5848-59 pubmed publisher
    ..We find that cellular Rab11 (a small GTP-binding protein involved in endocytic recycling) and Rab11-family interacting protein 3 ([FIP3] which ..
  82. Madsen K, Thorsen T, Rahbek Clemmensen T, Eriksen J, Gether U. Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway. J Biol Chem. 2012;287:12293-308 pubmed publisher
    ..2)-adrenergic receptor, which sorts to recycling upon internalization, led to formation of PICK1 co-clusters in Rab11-positive compartments...
  83. Lesteberg K, Orange J, Makedonas G. Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin. Immunol Res. 2017;65:1031-1045 pubmed publisher
    ..The recycling endosome pathway may serve as an auxiliary intracellular route for the delivery of new perforin to an immunologic synapse in order to perpetuate a cytotoxic response. ..
  84. Gallo L, Dalghi M, Clayton D, Ruiz W, Khandelwal P, Apodaca G. RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells. Am J Physiol Cell Physiol. 2017;:ajpcell.00218.2017 pubmed publisher
    ..We conclude that RAB27B, but not RAB27A, regulates DFV exocytosis in bladder umbrella cells in a manner that may be parallel to the previously described RAB11A-RAB8A-MYO5B pathway...
  85. Mammoto A, Sasaki T, Kim Y, Takai Y. Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking. J Biol Chem. 2000;275:13167-70 pubmed
    ..These results indicate that the rabphilin-11-mSec13p interaction is implicated in vesicle trafficking. ..
  86. Scales S, Hesser B, Masuda E, Scheller R. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. J Biol Chem. 2002;277:28271-9 pubmed
  87. Swiatecka Urban A, Talebian L, Kanno E, Moreau Marquis S, Coutermarsh B, Hansen K, et al. Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. J Biol Chem. 2007;282:23725-36 pubmed
    ..Taken together, these data indicate that myosin Vb is required for CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. ..
  88. Bouchet J, Del Río Iñiguez I, Lasserre R, Agüera González S, Cuche C, Danckaert A, et al. Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation. EMBO J. 2016;35:1160-74 pubmed publisher
    ..We show here that a significant fraction of Rac1 is associated with Rab11-positive recycling endosomes...
  89. Barcelona P, Jaldin Fincati J, Sanchez M, Chiabrando G. Activated ?2-macroglobulin induces Müller glial cell migration by regulating MT1-MMP activity through LRP1. FASEB J. 2013;27:3181-97 pubmed publisher
    ..Moreover, Rab11-dominant negative mutant abrogated MT1-MMP recycling pathway, cell migration, and proMMP-2 activation induced by ?..
  90. Hernández Bedolla M, González Domínguez E, Zavala Barrera C, Gutiérrez López T, Hidalgo Moyle J, Vazquez Prado J, et al. Calcium-sensing-receptor (CaSR) controls IL-6 secretion in metastatic breast cancer MDA-MB-231 cells by a dual mechanism revealed by agonist and inverse-agonist modulators. Mol Cell Endocrinol. 2016;436:159-68 pubmed publisher
    ..These results support the emerging potential of CaSR as a therapeutic target in metastatic breast cancer whose pharmacological modulation would reduce IL-6. ..
  91. Ho E, Ivanova I, Dagnino L. Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes. Biochim Biophys Acta. 2016;1863:2892-2904 pubmed publisher
    ..Our studies show a previously unrecognized role for ELMO2 and ILK in modulation of endosomal positioning, which may play key roles in epidermal sheet maintenance and permeability barrier function. ..