RAB10

Summary

Gene Symbol: RAB10
Description: RAB10, member RAS oncogene family
Alias: ras-related protein Rab-10, GTP-binding protein RAB10, ras-related GTP-binding protein
Species: human
Products:     RAB10

Top Publications

  1. Roland J, Lapierre L, Goldenring J. Alternative splicing in class V myosins determines association with Rab10. J Biol Chem. 2009;284:1213-23 pubmed publisher
    ..We have now determined that a related Rab protein, Rab10, can interact with myosin Va, myosin Vb, and myosin Vc...
  2. English A, Voeltz G. Rab10 GTPase regulates ER dynamics and morphology. Nat Cell Biol. 2013;15:169-78 pubmed publisher
    We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and dynamics...
  3. Miinea C, Sano H, Kane S, Sano E, Fukuda M, Peranen J, et al. AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J. 2005;391:87-93 pubmed
    ..Finally, it was found by immunoblotting that Rabs 2A, 8A and 14 are present in GLUT4 vesicles. These results indicate that AS160 is a Rab GAP, and suggest novel Rabs that may participate in GLUT4 translocation. ..
  4. Sano H, Peck G, Kettenbach A, Gerber S, Lienhard G. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. J Biol Chem. 2011;286:16541-5 pubmed publisher
    ..Insulin-elicited phosphorylation of the GTPase-activating protein TBC1D4 (AS160) suppresses its activity toward Rab10 and thereby leads to an increase in the GTP-bound form of Rab10, which in turn triggers movement of vesicles ..
  5. Larance M, Ramm G, St ckli J, van Dam E, Winata S, Wasinger V, et al. Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. J Biol Chem. 2005;280:37803-13 pubmed publisher
    ..soluble N-ethylmaleimide factor attachment protein (v-SNARE) VAMP2, we have identified three new Rab proteins, Rab10, Rab11, and Rab14, on GLUT4 vesicles...
  6. Babbey C, Ahktar N, Wang E, Chen C, Grant B, Dunn K. Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2006;17:3156-75 pubmed
    b>Rab10, a protein originally isolated from Madin-Darby Canine Kidney (MDCK) epithelial cells, belongs to a family of Rab proteins that includes Rab8 and Rab13...
  7. Funk N, Munz M, Ott T, Brockmann K, Wenninger Weinzierl A, Kühn R, et al. The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4. Sci Rep. 2019;9:4515 pubmed publisher
    ..Furthermore, we find a crucial role of Rab10 phosphorylation by LRRK2 for efficient insulin signal transduction...
  8. Etoh K, Fukuda M. Rab10 regulates tubular endosome formation through KIF13A and KIF13B motors. J Cell Sci. 2019;132: pubmed publisher
    ..In this study, we identified Rab10 as a novel protein localized at tubular endosomes by using a comprehensive localization screen of EGFP-tagged Rab ..
  9. Fan H, Li Y, Liu C, Liu Y, Bai J, Li W. Circular RNA-100290 promotes cell proliferation and inhibits apoptosis in acute myeloid leukemia cells via sponging miR-203. Biochem Biophys Res Commun. 2018;507:178-184 pubmed publisher
    ..Bioinformatic prediction and luciferase assay revealed that hsa_circ_100290 and Rab10 were targeted by miR-203...

More Information

Publications95

  1. Tavana J, Rosene M, Jensen N, Ridge P, Kauwe J, Karch C. RAB10: an Alzheimer's disease resilience locus and potential drug target. Clin Interv Aging. 2019;14:73-79 pubmed publisher
    ..One example is the discovery of a rare variant in the 3'-UTR of RAB10 that is protective for AD...
  2. Zhang P, Fan Y, Ru H, Wang L, Magupalli V, Taylor S, et al. Crystal structure of the WD40 domain dimer of LRRK2. Proc Natl Acad Sci U S A. 2019;116:1579-1584 pubmed publisher
    ..Assessment of full-length LRRK2 kinase activity by measuring phosphorylation of Rab10, a member of the family of Rab GTPases known to be important kinase substrates of LRRK2, shows enhancement of ..
  3. Leandrou E, Markidi E, Memou A, Melachroinou K, Greggio E, Rideout H. Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes. Biochem J. 2019;476:559-579 pubmed publisher
    ..Phosphorylation of the small GTPase Rab10 follows a similar pattern in which hetero-dimers of WT and mutant LRRK2 show similar levels of phosphorylation of ..
  4. Tian A, Lu M, Zhang F, Calderón Mantilla G, Petsalaki E, Tian X, et al. The pervasive effects of recombinant Fasciola gigantica Ras-related protein Rab10 on the functions of goat peripheral blood mononuclear cells. Parasit Vectors. 2018;11:579 pubmed publisher
    ..Here, we elucidated the role of F. gigantica Ras-related protein Rab10 (FgRab10) in the modulation of key functions of peripheral blood mononuclear cells (PBMCs) of goats...
  5. Melero Fernandez de Mera R, Arasu U, Kärnä R, Oikari S, Rilla K, Vigetti D, et al. Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2). Matrix Biol. 2018;: pubmed publisher
    ..TIRF microscopy analysis gave similar results. Rab10 silencing increased HA secretion by HAS2, likely by inhibiting endocytosis of the enzyme from PM, as reported ..
  6. Shikanai M, Yuzaki M, Kawauchi T. Rab family small GTPases-mediated regulation of intracellular logistics in neural development. Histol Histopathol. 2018;33:765-771 pubmed publisher
    ..Many Rab proteins, such as Rab5, Rab6, Rab7, Rab8, Rab10, Rab11, Rab17 and Rab18, are shown to regulate neurite outgrowth in PC12 cells and/or axon and dendrite formation ..
  7. Mafakheri S, Flörke R, Kanngießer S, Hartwig S, Espelage L, de Wendt C, et al. AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP. J Biol Chem. 2018;293:17853-17862 pubmed publisher
    ..Full-length TBC1D1 showed RabGAP activity toward GLUT4-associated Rab8a, Rab10, and Rab14, indicating similar substrate specificity as the truncated GAP domain...
  8. Bruno J, Brumfield A, Chaudhary N, Iaea D, McGraw T. SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. J Cell Biol. 2016;214:61-76 pubmed publisher
    b>RAB10 is a regulator of insulin-stimulated translocation of the GLUT4 glucose transporter to the plasma membrane (PM) of adipocytes, which is essential for whole-body glucose homeostasis...
  9. Su Z, Deshpande V, James D, Stöckli J. Tankyrase modulates insulin sensitivity in skeletal muscle cells by regulating the stability of GLUT4 vesicle proteins. J Biol Chem. 2018;293:8578-8587 pubmed publisher
    ..myotubes identified down-regulation of several glucose transporter GLUT4 storage vesicle (GSV) proteins including RAB10, VAMP8, SORT1, and GLUT4. A similar effect was observed following knockdown of tankyrase 1 in L6 myotubes...
  10. Zhang X, Zhang Y, Yang J, Li S, Chen J. Upregulation of miR-582-5p inhibits cell proliferation, cell cycle progression and invasion by targeting Rab27a in human colorectal carcinoma. Cancer Gene Ther. 2015;22:475-80 pubmed publisher
    ..Our data suggest that miR-582-5p may function as a tumor suppressor in the development of CRC by targeting Rab27a, indicating a novel therapeutic strategy for patients with CRC. ..
  11. Actis Dato V, Grosso R, Sanchez M, Fader C, Chiabrando G. Insulin-induced exocytosis regulates the cell surface level of low-density lipoprotein-related protein-1 in Müller Glial cells. Biochem J. 2018;475:1669-1685 pubmed publisher
    ..through intracellular activation of the IR/PI3K/Akt axis and Rab-GTPase proteins such as Rab8A and Rab10. In addition, these Rab-GTPases regulated both the constitutive and insulin-induced LRP1 translocation to the PM...
  12. Mir R, Tonelli F, Lis P, MacArtney T, Polinski N, Martinez T, et al. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. Biochem J. 2018;475:1861-1883 pubmed publisher
    ..We reveal that the VPS35[D620N] knock-in mutation strikingly elevates LRRK2-mediated phosphorylation of Rab8A, Rab10, and Rab12 in mouse embryonic fibroblasts...
  13. Zhang J, Chang D, Yang Y, Zhang X, Tao W, Jiang L, et al. Systematic investigation on the intracellular trafficking network of polymeric nanoparticles. Nanoscale. 2017;9:3269-3282 pubmed publisher
    ..The PLGA nanoparticles were transported out of the cells by GLUT4 transport vesicles (Rab8, Rab10 positive), classic secretory vesicles (Rab3, Rab27 positive vesicles) and melanosomes (Rab32, Rab38 positive ..
  14. Ho C, Wang J, Lee C, Cheng H, Wen W, Cheng H, et al. Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells. Biomed Pharmacother. 2014;68:1007-14 pubmed publisher
  15. Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, et al. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc Natl Acad Sci U S A. 2018;115:E9115-E9124 pubmed publisher
    ..family-wide screening of Rab GTPases that may act downstream of LRRK2 translocation revealed that Rab8a and Rab10 were specifically accumulated on overloaded lysosomes dependent on their phosphorylation by LRRK2...
  16. Andrzejewska Z, Nevo N, Thomas L, Chhuon C, Bailleux A, Chauvet V, et al. Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling. J Am Soc Nephrol. 2016;27:1678-88 pubmed publisher
    ..Furthermore, this study highlights the need to develop new treatments not dependent on lysosomal cystine depletion alone for this devastating disease. ..
  17. Sano H, Peck G, Blachon S, Lienhard G. A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b. Biochem Biophys Res Commun. 2015;465:601-5 pubmed publisher
    ..Previous studies have provided evidence that insulin signaling increases the amount of Rab10-GTP in the GLUT4 vesicles and that GLUT4 translocation requires the exocyst, a complex that functions in the ..
  18. Li L, Su S, Perry C, Elphick M, Chittka L, Søvik E. Large-scale transcriptome changes in the process of long-term visual memory formation in the bumblebee, Bombus terrestris. Sci Rep. 2018;8:534 pubmed publisher
    ..Several of the genes identified in this study (e.g. Rab10, Shank1 and Arhgap44) are interesting candidates for further investigation of the molecular mechanisms of long-..
  19. Suryawan A, Davis T. Amino Acid- and Insulin-Induced Activation of mTORC1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTOR, and RHEB-mTOR Complex Formation. J Nutr. 2018;148:825-833 pubmed publisher
  20. Kelly K, Wang S, Boddu R, Liu Z, Moukha Chafiq O, Augelli Szafran C, et al. The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition. Exp Neurol. 2018;309:1-13 pubmed publisher
    ..In rodents treated with inhibitors, parallel measurements of phospho-Rab10 revealed a poor correlation to phospho-LRRK2, likely due to cells that express Rab10 but poorly express LRRK2 in ..
  21. Di Maio R, Hoffman E, Rocha E, Keeney M, Sanders L, De Miranda B, et al. LRRK2 activation in idiopathic Parkinson's disease. Sci Transl Med. 2018;10: pubmed publisher
    ..We show that this occurred through an oxidative mechanism, resulting in phosphorylation of the LRRK2 substrate Rab10 and other downstream consequences including abnormalities in mitochondrial protein import and lysosomal function...
  22. Vanderwerf S, Buck D, Wilmarth P, Sears L, David L, Morton D, et al. Role for Rab10 in Methamphetamine-Induced Behavior. PLoS ONE. 2015;10:e0136167 pubmed publisher
    ..changes in the relative abundance of 23 raft proteins, including the monomeric GTP-binding protein Rab10, whose abundance in rafts was decreased 2.1-fold by acute methamphetamine treatment...
  23. Teo W, Yang Z, Kerr M, Luo L, Guo Z, Alexandrov K, et al. Salmonella effector SopD2 interferes with Rab34 function. Cell Biol Int. 2017;41:433-446 pubmed publisher
    ..SopD2 has recently been demonstrated to modulate multiple members of the Rab GTPase family such as Rab7, Rab8, Rab10, and Rab32 (D'Costa et al., , Cell Reports, 12:1508-18; Spano et al., , Cell Host & Microbe, 19:216-26)...
  24. Jaldin Fincati J, Pavarotti M, Frendo Cumbo S, Bilan P, Klip A. Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action. Trends Endocrinol Metab. 2017;28:597-611 pubmed publisher
    ..on Akt-targeted Rab GTPase-activating proteins (GAPs) (TBC1D1, TBC1D4, TBC1D13) and downstream Rab GTPases (Rab8a, Rab10, Rab13, Rab14, and their effectors) along with the input of Rac1 and actin filaments, molecular motors [myosinVa (..
  25. Truchan H, Cockburn C, Hebert K, Magunda F, Noh S, Carlyon J. The Pathogen-Occupied Vacuoles of Anaplasma phagocytophilum and Anaplasma marginale Interact with the Endoplasmic Reticulum. Front Cell Infect Microbiol. 2016;6:22 pubmed publisher
    ..A. phagocytophilum is known to hijack Rab10, a GTPase that regulates ER dynamics and morphology...
  26. Rinaldi F, Packer M, Collins R. New insights into the molecular mechanism of the Rab GTPase Sec4p activation. BMC Struct Biol. 2015;15:14 pubmed publisher
    ..Understanding the structural properties of mutants such as the one described here, provides useful insights into unique aspects of Rab GTPase function. ..
  27. Liu O, Grant B. Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes. PLoS Genet. 2015;11:e1005514 pubmed publisher
    ..elegans intestine. We demonstrate that downstream basolateral recycling regulators, GTPase RAB-10/Rab10 and BAR domain protein AMPH-1/Amphiphysin, bind to TBC-2 and help to recruit it to endosomes...
  28. Lalioti V, Ilari A, O Connell D, Poser E, Sandoval I, Colotti G. Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis. PLoS ONE. 2014;9:e85438 pubmed publisher
    ..These vesicles are positive to RyR, SERCA, calreticulin and Rab10. At the beginning of mitosis, sorcin-containing vesicles associate with the mitotic spindle, and during telophase ..
  29. Homma Y, Fukuda M. Rabin8 regulates neurite outgrowth in both GEF activity-dependent and -independent manners. Mol Biol Cell. 2016;27:2107-18 pubmed publisher
    ..and lipids to the tips of growing neurites by membrane trafficking, and although several Rabs, including Rab8, Rab10, and Rab11, have been implicated in this process, their regulatory mechanisms during neurite outgrowth are poorly ..
  30. Vazirani R, Verma A, Sadacca L, Buckman M, Picatoste B, Beg M, et al. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016;65:1577-89 pubmed publisher
    ..The small Rab GTPase, Rab10, is required for insulin-stimulated GLUT4 translocation in cultured 3T3-L1 adipocytes...
  31. Wang P, Liu H, Wang Y, Liu O, Zhang J, Gleason A, et al. RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes. PLoS Genet. 2016;12:e1006093 pubmed publisher
    ..Ehbp1) is a conserved regulator of endocytic recycling, acting as an effector of small GTPases including RAB-10 (Rab10)...
  32. Han M, Huang B, Chen A, Zhang X, Xu R, Wang J, et al. High expression of RAB43 predicts poor prognosis and is associated with epithelial-mesenchymal transition in gliomas. Oncol Rep. 2017;37:903-912 pubmed publisher
    ..In conclusion, a high level of RAB43 was significantly associated with the malignant phenotypes of gliomas, which suggests that RAB43 may serve as a novel biomarker and a potential therapeutic target for gliomas. ..
  33. Shih Y, Hsueh Y. The involvement of endoplasmic reticulum formation and protein synthesis efficiency in VCP- and ATL1-related neurological disorders. J Biomed Sci. 2018;25:2 pubmed publisher
    ..VCP), Atlastin-1 (ATL1), Spastin (SPAST), Reticulon 2 (RTN2), Receptor expression enhancing protein 1 (REEP1) and RAB10-suggesting a critical role of ER formation in neuronal activity and function...
  34. Brewer P, Habtemichael E, Romenskaia I, Mastick C, Coster A. Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation. J Biol Chem. 2016;291:773-89 pubmed publisher
    ..b>Rab10 knockdown decreased cell surface Glut4 in insulin-stimulated adipocytes by 65%, but not in basal adipocytes or in ..
  35. Mateus D, Marini E, Progida C, Bakke O. Rab7a modulates ER stress and ER morphology. Biochim Biophys Acta Mol Cell Res. 2018;1865:781-793 pubmed publisher
    ..Recently, the small GTPases Rab10 and Rab18 were reported to control ER shape by regulating ER dynamics and fusion...
  36. Zhang J, Kong R, Sun L. Silencing of Rab3D suppresses the proliferation and invasion of esophageal squamous cell carcinoma cells. Biomed Pharmacother. 2017;91:402-407 pubmed publisher
    ..Overall, these findings suggest that targeting the Rab3D may be a potential therapeutic target for treatment of ESCC. ..
  37. Galea G, Bexiga M, Panarella A, O Neill E, Simpson J. A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking. J Cell Sci. 2015;128:2339-49 pubmed publisher
    ..to demonstrating roles for Rab1a, Rab1b, Rab2a, and Rab6a or Rab6a' in this transport step, we also identified Rab10 and Rab11a as playing a role and being physically present on a proportion of the Golgi-to-ER tubular intermediates...
  38. Eyers P. Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease. Biochem J. 2018;475:185-189 pubmed publisher
    ..Recent work established that multiple Rab GTPases are physiological substrates of LRRK2, with Rab10 in particular emerging as a human substrate whose site-specific phosphorylation mirrors hyperactive LRRK2 lesions ..
  39. Karleuša L, Mahmutefendić H, Tomaš M, Zagorac G, Lučin P. Landmarks of endosomal remodeling in the early phase of cytomegalovirus infection. Virology. 2018;515:108-122 pubmed publisher
    ..Internalized cargo accumulates in Arf6-, Rab5-, Rab22A-, and Rab11-positive and Rab35-, Rab8-, and Rab10-negative juxtanuclear endosomes, suggesting the disruption of Arf/Rab regulatory cascade at the stage of sorting ..
  40. Ito G, Tomita T. Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag. J Vis Exp. 2017;: pubmed publisher
    ..Recent studies revealed that LRRK2 phosphorylates members of the Rab GTPase family, including Rab10, under physiological conditions...
  41. Liu J, Xiang J, Li X, Blankson S, Zhao S, Cai J, et al. NF-κB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection. Sci Rep. 2017;7:40418 pubmed publisher
    ..as knocking-down NOD1 and NOD2 substantially inhibited bacteria-induced activation of NF-κB and overexpression of Rab10 and Acp5, two membrane-trafficking regulators and lysosomal enzymes contributed to BLP tolerance-enhanced ..
  42. Li Z, Schulze R, Weller S, Krueger E, Schott M, Zhang X, et al. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Sci Adv. 2016;2:e1601470 pubmed publisher
    ..In hepatocytes stimulated to undergo autophagy, Rab10 activity is amplified significantly, concomitant with its increased recruitment to nascent autophagic membranes at ..
  43. Bao S, Zhu J, Garvey W. Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects. Horm Metab Res. 1998;30:656-62 pubmed
    ..Multiple Rab isoforms including Rab1A, Rab4A, Rab5B, Rab7, Rab8, Rab10, Rab12A, Rab13, Rab18, Rab21, and Rab22 mRNA were found to be expressed in human skeletal muscle...
  44. Karunanithi S, Xiong T, Uhm M, Leto D, Sun J, Chen X, et al. A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. Mol Biol Cell. 2014;25:3059-69 pubmed publisher
    ..the trafficking of Glut4 to the plasma membrane via regulation of a series of small G proteins, including RalA and Rab10. We demonstrate here that Rab10 is a bona fide target of the GTPase-activating protein AS160, which is inhibited ..
  45. Zhang Z, Zhao W, Ma F, Zhang H, Xu X. Rab10 Disruption Results in Delayed OPC Maturation. Cell Mol Neurobiol. 2017;37:1303-1310 pubmed publisher
    ..SiRNA and shRNA techniques and conditional knockout mice provided in vitro and in vivo evidence that Rab10 is involved in OPC maturation and may affect myelination during OPC development.
  46. Wang W, Jia W, Hu B, Pan Y. RAB10 overexpression promotes tumor growth and indicates poor prognosis of hepatocellular carcinoma. Oncotarget. 2017;8:26434-26447 pubmed publisher
    ..b>RAB10, a member of the RAS family, has been shown to be highly expressed in HCC...
  47. Zou L, Zhou J, Zhang J, Li J, Liu N, Chai L, et al. The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells. Proc Natl Acad Sci U S A. 2009;106:15801-6 pubmed publisher
    ..Together, these data demonstrate that Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation. ..
  48. Steger M, Diez F, Dhekne H, Lis P, Nirujogi R, Karayel Ö, et al. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. elife. 2017;6: pubmed publisher
    ..Here, we systematically analyzed the Rab protein family and found 14 of them (Rab3A/B/C/D, Rab5A/B/C, Rab8A/B, Rab10, Rab12, Rab29, Rab35 and Rab43) to be specifically phosphorylated by LRRK2, with evidence for endogenous ..
  49. Truchan H, Viebrock L, Cockburn C, Ojogun N, Griffin B, Wijesinghe D, et al. Anaplasma phagocytophilum Rab10-dependent parasitism of the trans-Golgi network is critical for completion of the infection cycle. Cell Microbiol. 2016;18:260-81 pubmed publisher
    ..We previously reported that A. phagocytophilum recruits green fluorescent protein (GFP)-tagged Rab10, a GTPase that directs exocytic traffic from the sphingolipid-rich trans-Golgi network (TGN) to its vacuole in a ..
  50. Zou W, Yadav S, Devault L, Nung Jan Y, Sherwood D. RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. PLoS Genet. 2015;11:e1005484 pubmed publisher
    ..Together these results suggest a crucial role for the Rab10 GTPase and the exocyst complex in controlling membrane transport from the secretory and/or endosomal compartments ..
  51. Ito G, Katsemonova K, Tonelli F, Lis P, Baptista M, Shpiro N, et al. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochem J. 2016;473:2671-85 pubmed publisher
    ..threonine/serine residue in the effector-binding switch-II motif of a number of Rab GTPase proteins, including Rab10. Here we describe a facile and robust method to assess phosphorylation of endogenous Rab10 in mouse embryonic ..
  52. Di J, Tang J, Qian H, Franklin D, Deisenroth C, Itahana Y, et al. p53 upregulates PLC?-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B. Oncotarget. 2017;8:64657-64669 pubmed publisher
    ..As a confirmed target gene of p53, we believe that further investigating potential functions of Rap2B in autophagy and tumorigenesis will provide a novel strategy for cancer therapy...
  53. Cao Z, Li C, Higginbotham J, Franklin J, Tabb D, Graves Deal R, et al. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics. 2008;7:1651-67 pubmed publisher
    ..b>Rab10 and myosin IIA were identified as core machinery, and Na(+)/K(+)-ATPase alpha1 was identified as an additional ..
  54. Zhang Z, Ma F, Zhang H, Xu X. MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation. Neurochem Res. 2017;42:2933-2939 pubmed publisher
    ..We found that either knockdown of MARCKS or interruption of its interaction with Rab10 would cause a decrease of the cell membrane area during OPC development...
  55. Fan Y, Howden A, Sarhan A, Lis P, Ito G, Martinez T, et al. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. Biochem J. 2018;475:23-44 pubmed publisher
    ..a facile and robust assay to quantify LRRK2 kinase pathway activity by measuring LRRK2-mediated phosphorylation of Rab10 in human peripheral blood neutrophils...
  56. Brewer P, Habtemichael E, Romenskaia I, Coster A, Mastick C. Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes. Biochem J. 2016;473:1315-27 pubmed publisher
    ..It has previously been shown that exocytosis of GSVs is rate-limited by Rab10, and both Rab10 and Rab14 are in vitro substrates of AS160...
  57. Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, et al. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. elife. 2016;5: pubmed publisher
    ..Our findings uncover a key class of bona-fide LRRK2 substrates and a novel regulatory mechanism of Rabs that connects them to PD. ..
  58. Gerondopoulos A, Bastos R, Yoshimura S, Anderson R, Carpanini S, Aligianis I, et al. Rab18 and a Rab18 GEF complex are required for normal ER structure. J Cell Biol. 2014;205:707-20 pubmed publisher
    ..Micro syndrome is therefore a disease characterized by direct loss of Rab18 function or loss of Rab18 activation at the ER by its GEF Rab3GAP. ..
  59. Bleimling N, Alexandrov K, Goody R, Itzen A. Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli. Protein Expr Purif. 2009;65:190-5 pubmed publisher
    ..The resultant protein was functionally active, as determined by GTPase activity and its interaction with the nucleotide exchange factor MSS4. ..
  60. Ramlal S, Mondal B, Lavu P, N B, Kingston J. Capture and detection of Staphylococcus aureus with dual labeled aptamers to cell surface components. Int J Food Microbiol. 2018;265:74-83 pubmed publisher
    ..Binding assays to assess the selectivity of aptamer RAB10, RAB 20, RAB 28 and RAB 35 demonstrated high affinity against S...
  61. Ridge P, Karch C, Hsu S, Arano I, Teerlink C, Ebbert M, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Med. 2017;9:100 pubmed publisher
    ..Finally, we experimentally characterized replicated SNPs. Rs142787485 in RAB10 confers significant protection against AD (p value?=?0.0184, odds ratio?=?0.5853)...
  62. Liu H, Wang S, Hang W, Gao J, Zhang W, Cheng Z, et al. LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling. J Cell Biol. 2018;217:299-314 pubmed publisher
    RAB-10/Rab10 is a master regulator of endocytic recycling in epithelial cells. To better understand the regulation of RAB-10 activity, we sought to identify RAB-10(GDP)-interacting proteins...
  63. Michaux G, Dyer C, Nightingale T, Gallaud E, Nurrish S, Cutler D. A role for Rab10 in von Willebrand factor release discovered by an AP-1 interactor screen in C. elegans. J Thromb Haemost. 2011;9:392-401 pubmed publisher
    ..elegans to identify new AP-1 genetic interactors. The small GTPase Rab10 was found to genetically interact with a partial loss of function of AP-1 in C. elegans...
  64. Jayadev R, Sherwood D. Tissue Sculpting by Fibrils. Dev Cell. 2016;38:1-3 pubmed publisher
    In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber...
  65. He X, Gong W, Zhang J, Nie J, Yao C, Guo F, et al. Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations. Cell Metab. 2018;27:151-166.e6 pubmed publisher
    ..Glutaminylation on apoptosis signal-regulating kinase 1 suppresses apoptosis. We discovered non-canonical functions of ARSs and revealed systematic and functional amino acid sensing and signal transduction networks. ..
  66. Babbey C, Bacallao R, Dunn K. Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. Am J Physiol Renal Physiol. 2010;299:F495-506 pubmed publisher
    b>Rab10, a mammalian homolog of the yeast Sec4p protein, has previously been associated with endocytic recycling and biosynthetic membrane transport in cultured epithelia and with Glut4 translocation in adipocytes...
  67. Li Z, Yue Y, Hu F, Zhang C, Ma X, Li N, et al. Electrical pulse stimulation induces GLUT4 glucose transporter translocation in C2C12 myotubes that depends on Rab8A, Rab13 and Rab14. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00103.2017 pubmed publisher
    ..In conclusion, EPS involves Rab8a, Rab13 and Rab14 to elicit GLUT4 translocation but not Rab10; moreover, Rab10 and Rab13 are not engaged by AMPK activation alone...
  68. Gulbranson D, Davis E, Demmitt B, Ouyang Y, Ye Y, Yu H, et al. RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc Natl Acad Sci U S A. 2017;114:E8224-E8233 pubmed publisher
    ..Instead, RABIF promotes the stability of Rab10, a key Rab in GLUT4 exocytosis...
  69. Liu Z, Bryant N, Kumaran R, Beilina A, Abeliovich A, Cookson M, et al. LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. Hum Mol Genet. 2017;: pubmed publisher
    ..Recently, a subset of Rab proteins have been identified as LRRK2 kinase substrates. Herein, we find that Rab8, Rab10, and Rab7L1 must be membrane and GTP-bound for LRRK2 phosphorylation...
  70. Lin Y, Ke C, Wang Y, Chen M, Chen T, Ku W, et al. RAB10 Interacts with the Male Germ Cell-Specific GTPase-Activating Protein during Mammalian Spermiogenesis. Int J Mol Sci. 2017;18: pubmed publisher
    ..g., RAB10, RAB5C, and RAP1), were identified using co-immunoprecipitation (co-IP) and nano liquid chromatography-mass ..
  71. Nakajo A, Yoshimura S, Togawa H, Kunii M, Iwano T, Izumi A, et al. EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. J Cell Biol. 2016;212:297-306 pubmed publisher
    ..In summary, our data demonstrate that EHBP1L1 links Rab8 and the Bin1-dynamin complex, which generates membrane curvature and excises the vesicle at the ERC for apical transport. ..
  72. Thirstrup K, Dachsel J, Oppermann F, Williamson D, Smith G, Fog K, et al. Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells. Sci Rep. 2017;7:10300 pubmed publisher
    ..Among the phospho-site hits were known LRRK2 sites as well as two phospho-sites on human Rab10 and Rab12...
  73. Zhao Y, Tan W, Sheng W, Li X. Identification of Biomarkers Associated With Alzheimer's Disease by Bioinformatics Analysis. Am J Alzheimers Dis Other Demen. 2016;31:163-8 pubmed publisher
    ..genes SEC22 vesicle trafficking protein homolog B (SEC22B) and SEC63 homolog (SEC63) regulated by miRNA-206, RAB10, member RAS oncogene family (RAB10) regulated by miRNA-655, and fms-related tyrosine kinase 1 (FLT1) regulated by ..
  74. Deen A, Rilla K, Oikari S, Kärnä R, Bart G, Häyrinen J, et al. Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen. J Biol Chem. 2014;289:8375-89 pubmed publisher
    ..In this study, we have identified Rab10 GTPase as the first protein known to be involved in the control of this traffic...
  75. Chen Y, Holcomb C, Moore H. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. Proc Natl Acad Sci U S A. 1993;90:6508-12 pubmed
    ..In mammals, Rab8 and Rab10 are the two small GTP-binding proteins identified so far that are closest to SEC4, an essential gene product ..
  76. Choudhury N, Nowak J, Zuo J, Rappsilber J, Spoel S, Michlewski G. Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation. Cell Rep. 2014;9:1265-72 pubmed
    ..These findings reveal that protein-modifying enzymes, only recently shown to bind RNA, can guide the function of canonical ribonucleoprotein (RNP) complexes in cis, thereby providing an additional level of specificity. ..
  77. Purlyte E, Dhekne H, Sarhan A, Gomez R, Lis P, Wightman M, et al. Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. EMBO J. 2018;37:1-18 pubmed publisher
    ..with these findings, knockout of Rab29 in A549 cells reduces endogenous LRRK2-mediated phosphorylation of Rab10. We show that mutations that prevent LRRK2 from interacting with either Rab29 or GTP strikingly inhibit ..
  78. Cardoso C, Jordao L, Vieira O. Rab10 regulates phagosome maturation and its overexpression rescues Mycobacterium-containing phagosomes maturation. Traffic. 2010;11:221-35 pubmed publisher
    ..identify more of the machinery involved in phagocytosis and phagosomal maturation, we investigated the function of Rab10 in engulfment and maturation of inert particles and Mycobacterium bovis bacille Calmette-Guérin (BCG)...
  79. Lindsay A, Jollivet F, Horgan C, Khan A, Raposo G, McCaffrey M, et al. Identification and characterization of multiple novel Rab-myosin Va interactions. Mol Biol Cell. 2013;24:3420-34 pubmed publisher
    ..Although the total pool of myosin Va is shared by several Rabs, Rab10 and Rab11 appear to be the major determinants of its recruitment to intracellular membranes...
  80. Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, et al. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012;198:545-60 pubmed publisher
    ..TIRF) microscopy and an insulin-responsive aminopeptidase (IRAP)-pHluorin fusion assay, we demonstrated that Rab10 directly facilitated GSV translocation to and docking at the PM...
  81. Chaudhary N, Gonzalez E, Chang S, Geng F, Rafii S, Altorki N, et al. Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes. Cell Rep. 2016;17:3305-3318 pubmed publisher
    ..Glut4, it enhances insulin-stimulated insertion of Glut4-containing vesicles to the plasma membrane independent of Rab10, a key regulator of Glut4 trafficking...
  82. Isabella A, Horne Badovinac S. Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis. Dev Cell. 2016;38:47-60 pubmed publisher
    ..We find that a Rab10-based secretion pathway promotes pericellular BM protein accumulation and fibril formation...
  83. Samad M, Mohsin M, Razu B, Hossain M, Mahzabeen S, Unnoor N, et al. [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hypergl. BMC Complement Altern Med. 2017;17:395 pubmed publisher
    ..in the membrane of the skeletal myocytes, which could be explained by the increased expression of Rab8 and Rab10 GTPases that are responsible for GLUT4 vesicle fusion to the membrane...
  84. Jiang W, Liu J, Xu T, Yu X. MiR-329 suppresses osteosarcoma development by downregulating Rab10. FEBS Lett. 2016;590:2973-81 pubmed publisher
    ..b>Rab10 was identified as a target of miR-329 in osteosarcoma and mediates its biofunction...
  85. Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, et al. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase. Biochem J. 2018;475:1-22 pubmed publisher
    ..Recent work has revealed that LRRK2 phosphorylates a subgroup of 14 Rab proteins, including Rab10, at a specific residue located at the centre of its effector-binding switch-II motif...
  86. Sonkoly E, Bata Csorgo Z, Pivarcsi A, Polyanka H, Kenderessy Szabo A, Molnar G, et al. Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS. J Biol Chem. 2005;280:24159-67 pubmed
    ..Our findings suggest that PRINS functions as a noncoding regulatory RNA, playing a protective role in cells exposed to stress. Furthermore, elevated PRINS expression in the epidermis may contribute to psoriasis susceptibility. ..