PUMA

Summary

Gene Symbol: PUMA
Description: BCL2 binding component 3
Alias: JFY-1, JFY1, PUMA, bcl-2-binding component 3, p53 up-regulated modulator of apoptosis, p53-upregulated modulator of apoptosis
Species: human
Products:     PUMA

Top Publications

  1. Yu J, Zhang L. PUMA, a potent killer with or without p53. Oncogene. 2008;27 Suppl 1:S71-83 pubmed publisher
    PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family member and a critical mediator of p53-dependent and -independent apoptosis induced by a wide variety of stimuli, including genotoxic stress, ..
  2. Bean G, Ganesan Y, Dong Y, Takeda S, Liu H, Chan P, et al. PUMA and BIM are required for oncogene inactivation-induced apoptosis. Sci Signal. 2013;6:ra20 pubmed publisher
    ..quot; We demonstrate that PUMA and BIM are the key apoptotic effectors of tyrosine kinase inhibitors in breast cancers with amplification of the ..
  3. Nakano K, Vousden K. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001;7:683-94 pubmed
    ..We have identified a novel gene named PUMA (p53 upregulated modulator of apoptosis) as a target for activation by p53...
  4. Cazanave S, Elmi N, Akazawa Y, Bronk S, Mott J, Gores G. CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis. Am J Physiol Gastrointest Liver Physiol. 2010;299:G236-43 pubmed publisher
    ..is dependent, in part, on the transcriptional upregulation of the BH3-only protein PUMA (p53 upregulated modulator of apoptosis)...
  5. Zhu H, Cao X, Ali Osman F, Keir S, Lo H. EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. Cancer Lett. 2010;294:101-10 pubmed publisher
    ..report that in glioblastoma, EGFR/EGFRvIII paradoxically co-expresses with p53-upregulated modulator of apoptosis (PUMA), a proapoptotic member of the Bcl-2 family of proteins primarily located on the mitochondria...
  6. Callus B, Moujallad D, Silke J, Gerl R, Jabbour A, Ekert P, et al. Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins. J Mol Biol. 2008;384:313-23 pubmed publisher
    Puma (p53 upregulated modulator of apoptosis) belongs to the BH3 (Bcl-2 homology 3)-only protein family of apoptotic regulators. Its expression is induced by various apoptotic stimuli, including irradiation and cytokine withdrawal...
  7. Luo X, He Q, Huang Y, Sheikh M. Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activation. Cell Death Differ. 2005;12:1310-8 pubmed
    b>PUMA, a key mediator of p53-induced apoptosis, is a BH3-only domain proapoptotic protein that localizes to mitochondria and interacts with antiapoptotic Bcl-2 and Bcl-X(L)...
  8. Ghosh A, Klocke B, Ballestas M, Roth K. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE. 2012;7:e39586 pubmed publisher
    ..PUMA (p53 upregulated modulator of apoptosis) and BIM (BCL2 interacting mediator of cell death), pro-apoptotic BH3 domain-only, BCL2 family ..
  9. Akazawa Y, Cazanave S, Mott J, Elmi N, Bronk S, Kohno S, et al. Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis. J Hepatol. 2010;52:586-93 pubmed publisher
    ..Palmitate increased expression of the BH3-only proteins PUMA and Bim, which was attenuated by palmitoleate...

More Information

Publications79

  1. Willis S, Fletcher J, Kaufmann T, van Delft M, Chen L, Czabotar P, et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science. 2007;315:856-9 pubmed
    ..and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma), even in cells with no Bim or Bid and reduced Puma...
  2. Mei Y, Du W, Yang Y, Wu M. Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1. Oncogene. 2005;24:7224-37 pubmed
    Although Puma (p53 upregulated modulator of apoptosis) was known as a principal mediator of cell death in response to diverse apoptotic signals, the molecular mechanism underlying its proapoptotic regulation remains largely ..
  3. Hoque M, Begum S, Sommer M, Lee T, Trink B, Ratovitski E, et al. PUMA in head and neck cancer. Cancer Lett. 2003;199:75-81 pubmed
    ..b>PUMA, a direct mediator of p53-associated apoptosis, was recently identified...
  4. Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong S, et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006;9:351-65 pubmed
    ..Our data allow us to distinguish a cellular state we call "primed for death," which can be determined by BH3 profiling and which correlates with dependence on antiapoptotic family members for survival. ..
  5. Wang P, Qiu W, Dudgeon C, Liu H, Huang C, Zambetti G, et al. PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis. Cell Death Differ. 2009;16:1192-202 pubmed publisher
    ..In this study, we found that p53 upregulated modulator of apoptosis (PUMA), a p53 downstream target and a BH3-only Bcl-2 family member, is directly regulated by NF-..
  6. Gallenne T, Gautier F, Oliver L, Hervouet E, Noël B, Hickman J, et al. Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. J Cell Biol. 2009;185:279-90 pubmed publisher
    It is still unclear whether the BH3-only protein Puma (p53 up-regulated modulator of apoptosis) can prime cells to death and render antiapoptotic BH3-binding Bcl-2 homologues necessary for survival through its ability to directly interact ..
  7. Zhang C, Zhang J, Zhang A, Wang Y, Han L, You Y, et al. PUMA is a novel target of miR-221/222 in human epithelial cancers. Int J Oncol. 2010;37:1621-6 pubmed
    ..Bioinformatics and luciferase reporter assays showed that miR-221/222 co-modulated the p53 upregulated modulator of apoptosis (PUMA) expression by directly targeting the binding site within the 3'UTR...
  8. Zhang C, Zhang J, Zhang A, Shi Z, Han L, Jia Z, et al. MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma. Mol Cancer. 2010;9:229 pubmed publisher
    ..Here we showed that miR-221/222 inhibited cell apoptosis by targeting pro-apoptotic gene PUMA in human glioma cells...
  9. Jiang F, Zhao W, Zhou L, Zhang L, Liu Z, Yu D. miR-222 regulates the cell biological behavior of oral squamous cell carcinoma by targeting PUMA. Oncol Rep. 2014;31:1255-62 pubmed publisher
    Previous reports have shown that low expression of p53 upregulated modulator of apoptosis (PUMA) and abnormal expression patterns of a number of miRNAs may be associated with poor prognosis in various types of human malignancies...
  10. Chipuk J, Green D. PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis. Cell Cycle. 2009;8:2692-6 pubmed
    ..We chose to examine the function of the BH3-only protein, p53 upregulated modulator of apoptosis (PUMA), to define its contribution to MOMP and cooperation with the direct activator proteins...
  11. Cazanave S, Mott J, Elmi N, Bronk S, Werneburg N, Akazawa Y, et al. JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem. 2009;284:26591-602 pubmed publisher
    ..The saturated FFA palmitate, but not the monounsaturated FFA oleate, induces an increase in PUMA mRNA and protein levels. Palmitate induction of PUMA was JNK1-dependent in primary murine hepatocytes...
  12. Chen L, Willis S, Wei A, Smith B, Fletcher J, Hinds M, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005;17:393-403 pubmed
    ..Bim and Puma potently engaged all the prosurvival proteins comparably...
  13. Gurzov E, Germano C, Cunha D, Ortis F, Vanderwinden J, Marchetti P, et al. p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem. 2010;285:19910-20 pubmed publisher
    ..combined with interferon-gamma, induces the expression of the Bcl-2 homology 3 (BH3)-only activator PUMA (p53 up-regulated modulator of apoptosis) in beta-cells...
  14. Sun Q, Ming L, Thomas S, Wang Y, Chen Z, Ferris R, et al. PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells. Oncogene. 2009;28:2348-57 pubmed publisher
    ..b>p53 upregulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family protein, is required for apoptosis induced by p53 and various ..
  15. Chipuk J, Fisher J, Dillon C, Kriwacki R, Kuwana T, Green D. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A. 2008;105:20327-32 pubmed publisher
    ..We examined the effect of ABT-737, a BCL-2 antagonist, and PUMA, a BH3-only protein that inhibits the entire anti-apoptotic BCL-2 repertoire, with cells and mitochondria that ..
  16. Li J, Lee B, Lee A. Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem. 2006;281:7260-70 pubmed
    ..mitochondrial apoptotic pathway, we have discovered that in MEFs, ER stress selectively activates BH3-only proteins PUMA and NOXA at the transcript level through the tumor suppressor gene p53...
  17. Ming L, Wang P, Bank A, Yu J, Zhang L. PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells. J Biol Chem. 2006;281:16034-42 pubmed
    b>PUMA is a BH3-only Bcl-2 family protein that plays an essential role in DNA damage-induced apoptosis. PUMA interacts with anti-apoptotic Bcl-2 and Bcl-X(L) and is dependent on Bax to induce apoptosis...
  18. Melino G, Bernassola F, Ranalli M, Yee K, Zong W, Corazzari M, et al. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem. 2004;279:8076-83 pubmed
    ..We found that p73-induced apoptosis is mediated by PUMA (p53 up-regulated modulator of apoptosis) induction, which, in turn, causes Bax mitochondrial translocation and ..
  19. Cartron P, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P, et al. The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Mol Cell. 2004;16:807-18 pubmed
    ..We report that the first alpha helix (Halpha1) of Bax specifically interacts with the BH3 domains of Bid and PUMA but not with that of Bad...
  20. Yu J, Zhang L, Hwang P, Kinzler K, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001;7:673-82 pubmed
    ..of genes that were expressed soon after p53 expression, we identified a novel gene termed PUMA (p53 upregulated modulator of apoptosis)...
  21. Han J, Flemington C, Houghton A, Gu Z, Zambetti G, Lutz R, et al. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001;98:11318-23 pubmed
    ..These results suggest that the transcriptional regulation of bbc3 contributes to the transduction of diverse cell death and survival signals. ..
  22. Dudgeon C, Wang P, Sun X, Peng R, Sun Q, Yu J, et al. PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Mol Cancer Ther. 2010;9:2893-902 pubmed publisher
    ..broad-range kinase inhibitor used in clinical trials, inhibits colon cancer cell growth by inducing apoptosis via PUMA, a BH3-only Bcl-2 family member and a p53 target...
  23. Chipuk J, Bouchier Hayes L, Kuwana T, Newmeyer D, Green D. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science. 2005;309:1732-5 pubmed
    ..Here, we demonstrate that a tripartite nexus between Bcl-xL, cytoplasmic p53, and PUMA coordinates these distinct p53 functions. After genotoxic stress, Bcl-xL sequestered cytoplasmic p53...
  24. Kuwana T, Bouchier Hayes L, Chipuk J, Bonzon C, Sullivan B, Green D, et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005;17:525-35 pubmed
    ..In this model, the simple inhibition of antiapoptotic functions is insufficient to induce apoptosis unless a direct activator of Bax or Bak is present. ..
  25. Sandow J, Jabbour A, Condina M, Daunt C, Stomski F, Green B, et al. Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell Death Differ. 2012;19:633-41 pubmed publisher
    P53-upregulated modifier of apoptosis (PUMA), a pro-apoptotic member of the Bcl-2 family, is transcriptionally activated by p53 and is a key effector of p53-dependent apoptosis...
  26. Cunha D, Igoillo Esteve M, Gurzov E, Germano C, Naamane N, Marhfour I, et al. Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes. 2012;61:2763-75 pubmed publisher
    ..and the induction of the BH3-only proteins death protein 5 (DP5) and p53-upregulated modulator of apoptosis (PUMA)...
  27. Zhao Z, Wang J, Tang J, Liu X, Zhong Q, Wang F, et al. JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells. Biochem J. 2012;444:291-301 pubmed publisher
    ..Our results from the present study indicate that Puma plays a critical role in the apoptosis of chemo-resistant ovarian cancer cells treated with BetA (betulinic acid)...
  28. Wang P, Yu J, Zhang L. The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc Natl Acad Sci U S A. 2007;104:4054-9 pubmed
    ..It has been shown that PUMA, a downstream target of p53 and a BH3-only Bcl-2 family member, plays an essential role in apoptosis induced by ..
  29. Spender L, Carter M, O Brien D, Clark L, Yu J, Michalak E, et al. Transforming growth factor-? directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas. J Biol Chem. 2013;288:5198-209 pubmed publisher
    ..Here we show that TGF-? induces the BH3-only activator PUMA to aid induction of the intrinsic cell death pathway...
  30. Yu J, Wang Z, Kinzler K, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci U S A. 2003;100:1931-6 pubmed
    ..If p21 is disrupted via gene targeting, the cells die through apoptosis. If the PUMA gene is also disrupted in such cells, apoptosis is prevented...
  31. Ming L, Sakaida T, Yue W, Jha A, Zhang L, Yu J. Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis. 2008;29:1878-84 pubmed publisher
    p53-upregulated modulator of apoptosis (PUMA) plays an essential role in p53-dependent apoptosis following DNA damage. PUMA also mediates apoptosis independent of p53...
  32. Yuan Z, Cao K, Lin C, Li L, Liu H, Zhao X, et al. The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. Mol Med. 2011;17:1262-74 pubmed publisher
    ..PUMA (p53 upregulated modulator of apoptosis), a BH3-only Bcl-2 family protein, was recently identified as a transcriptional target of p53 and ..
  33. Clybouw C, Fischer S, Auffredou M, Hugues P, Alexia C, Bouillet P, et al. Regulation of memory B-cell survival by the BH3-only protein Puma. Blood. 2011;118:4120-8 pubmed publisher
    ..In this report, we show that expression of the proapoptotic BH3-only Bcl-2 family member Puma was selectively up-regulated on in vitro activation with antigens or mitogens of both human and mouse B cells...
  34. Gomes N, Espinosa J. Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes Dev. 2010;24:1022-34 pubmed publisher
    ..Here we report that PUMA (p53 up-regulated modulator of apoptosis), a key mediator of p53-dependent cell death, is regulated by a ..
  35. Garrison S, Jeffers J, Yang C, Nilsson J, Hall M, Rehg J, et al. Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol. 2008;28:5391-402 pubmed publisher
    ..A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein...
  36. La Colla A, Vasconsuelo A, Milanesi L, Pronsato L. 17β-Estradiol Protects Skeletal Myoblasts From Apoptosis Through p53, Bcl-2, and FoxO Families. J Cell Biochem. 2017;118:104-115 pubmed publisher
    ..H2 O2 modulating p53 and FoxO transcription factors and then their target genes Bcl-2, Bim, Puma, PERP, and MDM2, without affecting Noxa gene...
  37. Zhao B, Li R, Yang F, Yu F, Xu N, Zhang F, et al. LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus. Sci Rep. 2018;8:763 pubmed publisher
    ..In addition, vitamin D/VDR signaling inhibited LPS-induced p53-upregulated modulator of apoptosis (PUMA) induction in keratinocytes via impeding nuclear factor-κB (NF-κB) activation, resulting in keratinocytes ..
  38. Alsharari S, Al Rejaie S, Abuohashish H, Ahmed M, Hafez M. Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats. Oxid Med Cell Longev. 2016;2016:5436745 pubmed publisher
    ..Conclusion. TGF-?/Smad signaling pathway is involved in HCD-induced hepatotoxicity and Rutin inhibits the hepatotoxicity via suppressing this pathway. Therefore, Rutin might be considered as a protective agent for hepatotoxicity. ..
  39. Xu C, Zhang L, Duan L, Lu C. MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA. Oncotarget. 2016;7:77764-77776 pubmed publisher
    ..identified as a target of H2AX and shown to inhibit apoptosis in lung cancer cells by targeting p53 upregulated modulator of apoptosis (PUMA)...
  40. Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X, et al. Involvement of PUMA in pericyte migration induced by methamphetamine. Exp Cell Res. 2017;356:28-39 pubmed publisher
    ..The results showed that exposure of C3H/10T1/2 cells and HBVPs to methamphetamine increased PUMA expression via activation of the sigma-1 receptor, MAPK and Akt/PI3K pathways...
  41. Yang J, Zhao X, Tang M, Li L, Lei Y, Cheng P, et al. The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells. Oncotarget. 2017;8:23492-23506 pubmed publisher
    b>PUMA is a member of the "BH3-only" branch of the BCL-2 family. Our previous study suggests a therapeutic potential of PUMA in treating ovarian cancer, however, the action mechanism of PUMA remains elusive...
  42. Lai X, Deng Z, Guo H, Zhu X, Tu W. HP1? is highly expressed in glioma cells and facilitates cell proliferation and survival. Cancer Biomark. 2017;20:453-460 pubmed publisher
    ..Furthermore, we find that HP1? and H3K9me3 are enriched in the FAS and PUMA promoters, which suggests that upregulated HP1? and H3K9me3 prevent apoptosis by suppressing apoptotic activators...
  43. Park S, Jeong M, Jang S. In vitro binding properties of tumor suppressor p53 with PUMA and NOXA. Biochem Biophys Res Commun. 2012;420:350-6 pubmed publisher
    The p53-upregulated modulator of apoptosis (Puma) and Noxa, are direct targets in p53-mediated apoptosis localized to the mitochondria...
  44. Heinicke U, Kupka J, Fichter I, Fulda S. Critical role of mitochondria-mediated apoptosis for JNJ-26481585-induced antitumor activity in rhabdomyosarcoma. Oncogene. 2016;35:3729-41 pubmed publisher
    ..JNJ-26481585 upregulates expression levels of several BH3-only proteins including Bim, Puma and Noxa, which all contribute to JNJ-26481585-mediated apoptosis, as knockdown of Bim, Puma or Noxa significantly ..
  45. Mantawy E, Esmat A, El Bakly W, Salah ElDin R, El Demerdash E. Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways. Sci Rep. 2017;7:4795 pubmed publisher
    ..Moreover, chrysin attenuated DOX-induced apoptosis via decreasing expression of p53, Bax, Puma, Noxa, cytochrome c and caspase-3 while increasing expression of Bcl-2...
  46. Ochoa A, Onorato D, Fitak R, Roelke Parker M, Culver M. Evolutionary and Functional Mitogenomics Associated With the Genetic Restoration of the Florida Panther. J Hered. 2017;108:449-455 pubmed publisher
    ..With the addition of 2 puma mitogenomes, we characterized 174 single nucleotide polymorphisms (SNPs) across 12 individuals...
  47. Li W, Du B, Wang T, Wang S, Zhang J. Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis. Chem Biol Interact. 2009;177:121-7 pubmed publisher
    ..The Bcl-2 family proteins including PUMA were involved in this process...
  48. Geden M, Deshmukh M. Axon degeneration: context defines distinct pathways. Curr Opin Neurobiol. 2016;39:108-15 pubmed publisher
    ..g. DLK, JNKs, GSK3α/β) and execution (e.g. Puma, Bax, caspase-9, caspase-3)...
  49. Jou Y, Hua C, Lin C, Wang C, Wan L, Lin Y, et al. Anticancer Activity of γ-Bisabolene in Human Neuroblastoma Cells via Induction of p53-Mediated Mitochondrial Apoptosis. Molecules. 2016;21: pubmed publisher
    ..Moreover, γ-bisabolene increased p53 phosphorylation and up-regulated p53-mediated apoptotic genes Bim and PUMA, as well as decreased the mRNA and protein levels of CK2α...
  50. Miller E, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, et al. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. J Am Heart Assoc. 2015;5: pubmed publisher
    ..with evidence of increased apoptosis and apoptotic signaling via caspase 3 and p53/PUMA (p53 upregulated modulator of apoptosis) and more severe mitochondrial dysfunction...
  51. Tan S, Li L, Chen T, Chen X, Tao L, Lin X, et al. β-Arrestin-1 protects against endoplasmic reticulum stress/p53-upregulated modulator of apoptosis-mediated apoptosis via repressing p-p65/inducible nitric oxide synthase in portal hypertensive gastropathy. Free Radic Biol Med. 2015;87:69-83 pubmed publisher
    ..of β-arr1 in PHG via its regulation of endoplasmic reticulum (ER) stress/p53-upregulated modulator of apoptosis (PUMA) apoptotic signaling. Gastric mucosal injury and apoptosis were studied in PHG patients and in PHG mouse models...
  52. Shang X, Vasudevan S, Yu Y, Ge N, Ludwig A, Wesson C, et al. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. 2010;29:4938-46 pubmed publisher
    ..in the IMR-32 neuroblastoma cell line enhanced doxorubicin-induced p53 phosphorylation at Ser20 and Ser37, p21, Puma, Bax expression as well as apoptosis...
  53. Sun C, Zhuang J, Teng W, Wang Z, Du S. PUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells. Genet Mol Res. 2015;14:5742-9 pubmed publisher
    We explored whether p53 upregulated modulator of apoptosis (PUMA) gene transfection could enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells...
  54. Concannon C, Koehler B, Reimertz C, Murphy B, Bonner C, Thurow N, et al. Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway. Oncogene. 2007;26:1681-92 pubmed
    ..triggered transcriptional activation of the two Bcl-2-homology domain-3-only (BH3-only) genes p53 upregulated modulator of apoptosis (PUMA) and Bim...
  55. Braun F, Bertin Ciftci J, Gallouet A, Millour J, Juin P. Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition. PLoS ONE. 2011;6:e23577 pubmed publisher
    ..starvation enhances, independently from p53, the expression of p21 and that of the pro-apoptotic BH3-only protein Puma. Under these conditions, p21 prevents Puma and its downstream effector Bax from triggering the mitochondrial ..
  56. Wali J, Rondas D, McKenzie M, Zhao Y, Elkerbout L, Fynch S, et al. The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity. Cell Death Dis. 2014;5:e1124 pubmed publisher
    ..apoptosis of islet cells, and this requires the proapoptotic Bcl-2 homology domain 3 (BH3)-only proteins Bim and Puma. We studied the stress pathways induced by glucotoxicity in beta cells that result in apoptosis...
  57. Dabrowska A, Kim N, Aldovini A. Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. J Immunol. 2008;181:8460-77 pubmed
    ..The FOXO3a target genes Fas ligand and TRAIL, involved in the extrinsic apoptotic pathway, and PUMA, Noxa, and Bim, which are part of the intrinsic apoptotic pathway, were also up-regulated, indicating that HIV ..
  58. Filoni C, Helfer Hungerbuehler A, Catão Dias J, Marques M, Torres L, Reinacher M, et al. Putative progressive and abortive feline leukemia virus infection outcomes in captive jaguarundis (Puma yagouaroundi). Virol J. 2017;14:226 pubmed publisher
    ..Jaguarundis (Puma yagouaroundi) are small wild felids from South and Central America...
  59. Yang H, Xie Y, Yang D, Ren D. Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma. Oncotarget. 2017;8:25310-25322 pubmed publisher
    ..H2O2 induced an increase in Bax, Bak and Puma, and a decrease in anti-apoptotic molecules such as Bcl-2, Bcl-xL and Mcl-1...
  60. Lam D, Dickens D, Reid E, Loh S, Moisoi N, Martins L. MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proc Natl Acad Sci U S A. 2009;106:11978-83 pubmed publisher
    ..that this pro-apoptotic kinase orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM...
  61. Pilchova I, Klacanova K, Dibdiakova K, Saksonova S, Stefániková A, Vidomanová E, et al. Proteasome Stress Triggers Death of SH-SY5Y and T98G Cells via Different Cellular Mechanisms. Neurochem Res. 2017;42:3170-3185 pubmed publisher
    ..of caspase 3 in SH-SY5Y cells that was probably a result of increased expression of pro-apoptotic proteins, PUMA and Noxa...
  62. Yang W, Hosford S, Traphagen N, Shee K, Demidenko E, Liu S, et al. Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor-positive breast cancer. FASEB J. 2017;: pubmed publisher
    ..induced mitochondrial membrane depolarization, which required the BH3-only proapoptotic proteins Bim and PUMA. Treatment with GDC-0941, CQ, or the combination, significantly suppressed the growth of ER+ breast ..
  63. Ishihara T, Hoshino T, Namba T, Tanaka K, Mizushima T. Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis. Biochem Biophys Res Commun. 2007;356:711-7 pubmed
    ..We report here that various NSAIDs, including celecoxib, up-regulate PUMA, a Bcl-2 family protein with potent apoptosis-inducing activity, in human gastric carcinoma cell line, accompanying ..
  64. Wei G, Margolin A, Haery L, Brown E, Cucolo L, Julian B, et al. Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. Cancer Cell. 2012;21:547-62 pubmed publisher
    ..A computational model, validated in vivo, indicated that high BCL-xL expression confers resistance to MCL1 repression, thereby identifying a patient-selection strategy for the clinical development of MCL1 inhibitors. ..
  65. Azad A, Storey A. Chk1 activity is required for BAK multimerization in association with PUMA during mitochondrial apoptosis. Cell Commun Signal. 2014;12:42 pubmed publisher
    ..Interestingly, co-immunoprecipitation studies suggest that Chk1 is required for recruitment of BH3- only protein PUMA to BAK. We also showed that Chk1 is associated with BAK upon DNA damage...
  66. Meng X, Lee S, Dai H, Loegering D, Yu C, Flatten K, et al. Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization. J Biol Chem. 2007;282:29831-46 pubmed
    ..In addition, TRAIL caused increased binding of Bim and Puma to Mcl-1 that was inhibited by IETD(OMe)-fmk but not SP600125...
  67. Dey P, Strom A, Gustafsson J. Estrogen receptor ? upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene. 2014;33:4213-25 pubmed publisher
    ..ER? causes apoptosis by increasing the expression of pro-apoptotic factor p53-upregulated modulator of apoptosis (PUMA), independent of p53, but dependent on the forkhead transcription factor class-O family member, FOXO3a...
  68. Cai W, Li Q, Yang Z, Miao X, Wen Y, Huang S, et al. Expression of p53 upregulated modulator of apoptosis (PUMA) and C-myb in gallbladder adenocarcinoma and their pathological significance. Clin Transl Oncol. 2013;15:818-24 pubmed publisher
    An increasing number of studies have shown that PUMA and C-myb signaling pathways are involved in various human cancers including colon carcinomas...
  69. Matsumoto T, Uchiumi T, Monji K, Yagi M, Setoyama D, Amamoto R, et al. Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity. Oncogenesis. 2017;6:397 pubmed publisher
    ..factor 4 (ATF4) mediated expression of ER stress response and led to p53-upregulated modulator of apoptosis (PUMA)-dependent apoptosis only in the cancer stem-like cells...
  70. Liu F, Newland A, Jia L. Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. Biochem Biophys Res Commun. 2003;310:956-62 pubmed
    The BH3-only protein, PUMA, plays an important role in p53-mediated apoptosis. The apoptotic effect of PUMA on the mitochondria was studied using a p53-negative, human leukemia K562 cell line...