PU 1

Summary

Gene Symbol: PU 1
Description: Spi-1 proto-oncogene
Alias: PU.1, SFPI1, SPI-1, SPI-A, transcription factor PU.1, 31 kDa transforming protein, hematopoietic transcription factor PU.1, spleen focus forming virus (SFFV) proviral integration oncogene spi1
Species: human
Products:     PU 1

Top Publications

  1. Bonfield T, Raychaudhuri B, Malur A, Abraham S, Trapnell B, Kavuru M, et al. PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1132-6 pubmed
    ..1 and M-CSFR expression in alveolar macrophages compared with healthy control and PAP patients before GM-CSF therapy. These observations suggest that PU.1 is critical in the terminal differentiation of human alveolar macrophages. ..
  2. Tsuneto M, Tominaga A, Yamazaki H, Yoshino M, Orkin S, Hayashi S. Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. Stem Cells. 2005;23:134-43 pubmed
    ..These results suggest that the expression of PU.1 is a critical event for osteoclastogenesis and that Tal-1 may lie upstream of PU.1 in a regulatory hierarchy during osteoclastogenesis. ..
  3. Mueller B, Pabst T, Fos J, Petkovic V, Fey M, Asou N, et al. ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression. Blood. 2006;107:3330-8 pubmed
    ..This is the first report to show that PU.1 is suppressed in acute promyelocytic leukemia, and that ATRA restores PU.1 expression in cells harboring t(15;17). ..
  4. Tatetsu H, Ueno S, Hata H, Yamada Y, Takeya M, Mitsuya H, et al. Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth. Cancer Res. 2007;67:5328-36 pubmed
    ..1 is an essential step for the survival of a subset of myeloma cells and that up-regulation of PU.1 by demethylation agents or other types of agents may represent a new therapeutic strategy for treatment of multiple myeloma patients. ..
  5. Albajar M, Gutierrez P, Richard C, Rosa Garrido M, Gomez Casares M, Steegmann J, et al. PU.1 expression is restored upon treatment of chronic myeloid leukemia patients. Cancer Lett. 2008;270:328-36 pubmed publisher
    ..These effects are not found in patients with other myeloproliferative diseases such as polycythemia vera or essential thrombocythemia. PU.1 could, therefore, be used as an additional marker of the response to the treatment of the CML. ..
  6. Burda P, Curik N, Kokavec J, Basova P, Mikulenkova D, Skoultchi A, et al. PU.1 activation relieves GATA-1-mediated repression of Cebpa and Cbfb during leukemia differentiation. Mol Cancer Res. 2009;7:1693-703 pubmed publisher
    ..Collectively, we show that either activation of PU.1 or inhibition of GATA-1 efficiently reverses the transcriptional block imposed by GATA-1 and leads to the activation of a myeloid transcriptional program directed by PU.1. ..
  7. Wang K, Wang P, Shi J, Zhu X, He M, Jia X, et al. PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell. 2010;17:186-97 pubmed publisher
    ..Thus, selective targeting of PU.1-regulated genes by PML/RARalpha is a critical mechanism for the pathogenesis of APL. ..
  8. Brass A, Zhu A, Singh H. Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers. EMBO J. 1999;18:977-91 pubmed
    ..1 and Pip from one regulated by PU.1 alone. This strategy should prove generally useful in analyzing the function of interacting transcription factors in vivo, and for identifying novel genes regulated by such complexes. ..
  9. Rehli M, Poltorak A, Schwarzfischer L, Krause S, Andreesen R, Beutler B. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J Biol Chem. 2000;275:9773-81 pubmed
    ..Cloning of the human TLR4 gene provides a basis for further investigation of the possible impact of genetic variations on the susceptibility to infection and sepsis. ..

More Information

Publications116 found, 100 shown here

  1. Matushansky I, Radparvar F, Skoultchi A. CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene. 2003;22:4143-9 pubmed
    ..Our findings suggest that studying the relative roles of CDK6 and CDK4 in other types of malignant cells will be important in designing approaches for cell cycle inhibition and differentiation therapy in cancer. ..
  2. Suzuki M, Yamada T, Kihara Negishi F, Sakurai T, Hara E, Tenen D, et al. Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. Oncogene. 2006;25:2477-88 pubmed
    ..1 in NIH3T3 cells, accompanied by a downregulation of p16(INK4A) gene expression. These results suggest that PU.1 may downregulate its target genes through an epigenetic modification such as DNA methylation. ..
  3. Martinez Nunez R, Louafi F, Friedmann P, Sanchez Elsner T. MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN). J Biol Chem. 2009;284:16334-42 pubmed publisher
    ..Thus, our results suggest a mechanism by which miR-155 regulates proteins involved in the cellular immune response against pathogens that could have clinical implications in the way pathogens enter the human organism. ..
  4. Imoto A, Okada M, Okazaki T, Kitasato H, Harigae H, Takahashi S. Metallothionein-1 isoforms and vimentin are direct PU.1 downstream target genes in leukemia cells. J Biol Chem. 2010;285:10300-9 pubmed publisher
    ..Bisulfite sequencing analyses of the PU.1-bound regions of these promoters revealed that the proportions of methylated CpG sites were tightly related to the PU.1 expression levels. ..
  5. Leddin M, Perrod C, Hoogenkamp M, Ghani S, Assi S, Heinz S, et al. Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells. Blood. 2011;117:2827-38 pubmed publisher
    ..1 regulates its expression in B cells and macrophages by differentially associating with cell type-specific transcription factors at one of its cis-regulatory elements to establish differential activity patterns at other elements. ..
  6. Klemsz M, McKercher S, Celada A, Van Beveren C, Maki R. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell. 1990;61:113-24 pubmed
    ..1 protein placed the DNA binding domain in the highly basic carboxy-terminal domain of the protein. The amino acid sequence in the binding domain of PU.1 has considerable identity with proteins belonging to the ets oncogene family. ..
  7. Vangala R, Heiss Neumann M, Rangatia J, Singh S, Schoch C, Tenen D, et al. The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood. 2003;101:270-7 pubmed
    ..1, however, differentiates AML1-ETO-expressing Kasumi-1 cells to the monocytic lineage. Thus, the function of PU.1 is down-regulated by AML1-ETO in t(8;21) myeloid leukemia, whereas overexpression of PU.1 restores normal differentiation. ..
  8. Rosa A, Ballarino M, Sorrentino A, Sthandier O, De Angelis F, Marchioni M, et al. The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci U S A. 2007;104:19849-54 pubmed
    ..These data point to the important role of miR-424 and NFI-A in controlling the monocyte/macrophage differentiation program. ..
  9. Gupta P, Gurudutta G, Saluja D, Tripathi R. PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis. J Cell Mol Med. 2009;13:4349-63 pubmed publisher
  10. Ueno S, Tatetsu H, Hata H, Iino T, Niiro H, Akashi K, et al. PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL. Oncogene. 2009;28:4116-25 pubmed publisher
    ..1-binding site in the TRAIL promoter eliminated this transactivation. Therefore, we conclude that PU.1 is capable of inducing apoptosis in certain myeloma cells by direct transactivation of TRAIL. ..
  11. Ban G, Kang D, Yoon H. Transcriptional response of selected genes of Salmonella enterica serovar Typhimurium biofilm cells during inactivation by superheated steam. Int J Food Microbiol. 2015;192:117-23 pubmed publisher
    ..Understanding the status of Salmonella virulence and stress resistance induced by SHS treatments is important for wider application of SHS in controlling Salmonella biofilm formation during food production. ..
  12. Chen W, Zhu G, Tang J, Zhou H, Li Y. C/ebpα controls osteoclast terminal differentiation, activation, function, and postnatal bone homeostasis through direct regulation of Nfatc1. J Pathol. 2018;244:271-282 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  13. Kim S, Kim E, Park S, Hahn T, Yoon H. Genomic Approaches for Understanding the Characteristics of Salmonella enterica subsp. enterica Serovar Typhimurium ST1120, Isolated from Swine Feces in Korea. J Microbiol Biotechnol. 2017;27:1983-1993 pubmed publisher
    ..Comparative genome analysis between ST1120 and other Salmonella strains would provide fruitful information toward understanding Salmonella host specificity and developing control measures against S. Typhimurium infection...
  14. Ruan H, Zhang Z, Tian L, Wang S, Hu S, Qiao J. The Salmonella effector SopB prevents ROS-induced apoptosis of epithelial cells by retarding TRAF6 recruitment to mitochondria. Biochem Biophys Res Commun. 2016;478:618-23 pubmed publisher
    ..These findings show that SopB suppresses host cell apoptosis by binding to TRAF6 and preventing mitochondrial ROS generation. ..
  15. He Y, Jiang Z, Chen C, Wang X. Classification of triple-negative breast cancers based on Immunogenomic profiling. J Exp Clin Cancer Res. 2018;37:327 pubmed publisher
    ..The identification of TNBC subtypes based on immune signatures has potential clinical implications for TNBC treatment. ..
  16. Jaiswal S, Sahoo P, Ryan D, Das J, Chakraborty E, Mohakud N, et al. Altered virulence potential of Salmonella Enteritidis cultured in different foods: A cumulative effect of differential gene expression and immunomodulation. Int J Food Microbiol. 2016;230:64-72 pubmed publisher
    ..Enteritidis. ..
  17. Yashiro T, Yamaguchi M, Watanuki Y, Kasakura K, Nishiyama C. The Transcription Factors PU.1 and IRF4 Determine Dendritic Cell-Specific Expression of RALDH2. J Immunol. 2018;201:3677-3682 pubmed publisher
    ..1 recruitment to the Aldh1a2 promoter were enhanced. We conclude that PU.1 and IRF4 are transactivators of the Aldh1a2 gene in vitro and ex vivo. ..
  18. Wiesner M, Calva J, Bustamante V, Pérez Morales D, Fernández Mora M, Calva E, et al. A multi-drug resistant Salmonella Typhimurium ST213 human-invasive strain (33676) containing the bla CMY-2 gene on an IncF plasmid is attenuated for virulence in BALB/c mice. BMC Microbiol. 2016;16:18 pubmed publisher
    ..To our knowledge this is the first report of an IncF bla CMY-2-carrying plasmid in Salmonella. ..
  19. Elhadad D, Desai P, Rahav G, McClelland M, Gal Mor O. Flagellin Is Required for Host Cell Invasion and Normal Salmonella Pathogenicity Island 1 Expression by Salmonella enterica Serovar Paratyphi A. Infect Immun. 2015;83:3355-68 pubmed publisher
    ..Paratyphi A that does not occur in S. Typhimurium and demonstrate curious distinctions in motility and the expression of the flagellum-chemotaxis regulon between these clinically relevant pathogens. ..
  20. Lu J, Hsieh M, Hou H, Chen C, Tien H, Lin L. Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish. Blood Cancer J. 2017;7:e593 pubmed publisher
    ..These results suggest that SOX4 is not only an independent prognostic factor of AML, but also an important molecular factor in leukemogenesis. ..
  21. Di Napoli A, De Cecco L, Piccaluga P, Navari M, Cancila V, Cippitelli C, et al. Transcriptional analysis distinguishes breast implant-associated anaplastic large cell lymphoma from other peripheral T-cell lymphomas. Mod Pathol. 2019;32:216-230 pubmed publisher
    ..Our findings provide novel insights into the biology of this rare disease and further evidence that breast implant-associated anaplastic large cell lymphoma represents a distinct peripheral T-cell lymphoma entity. ..
  22. Frank C, Manandhar D, Gordân R, Crawford G. HDAC inhibitors cause site-specific chromatin remodeling at PU.1-bound enhancers in K562 cells. Epigenetics Chromatin. 2016;9:15 pubmed publisher
    ..PU.1 shows evidence of a pioneer role in this process by marking poised enhancers but is not required for transcriptional activation. ..
  23. Hou H, Lu J, Lin T, Tsai C, Chou W, Lin C, et al. Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia. Blood Cancer J. 2017;7:e588 pubmed publisher
    ..The SOCS1/FLT3-ITD double transgenic fish could further facilitate the leukemic process. The results indicate SOCS1 plays an important role in AML and its higher expression serves as a new biomarker to risk-stratify AML patients. ..
  24. Lathrop S, Binder K, Starr T, Cooper K, Chong A, Carmody A, et al. Replication of Salmonella enterica Serovar Typhimurium in Human Monocyte-Derived Macrophages. Infect Immun. 2015;83:2661-71 pubmed publisher
    ..Only SPI2-dependent replication was associated with death of the host cell at later time points. Altogether, our results reveal a very nuanced interaction between Salmonella and human macrophages. ..
  25. Cheng J, Chen L, Li Y, Cloe A, Yue M, Wei J, et al. RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nat Commun. 2018;9:1163 pubmed publisher
    ..This study reveals novel RNA:m5C/RCMT-mediated chromatin structures that modulate 5-AZA response/resistance in leukaemia cells, and hence provides a new insight into treatment of leukaemia. ..
  26. Carden S, Okoro C, Dougan G, Monack D. Non-typhoidal Salmonella Typhimurium ST313 isolates that cause bacteremia in humans stimulate less inflammasome activation than ST19 isolates associated with gastroenteritis. Pathog Dis. 2015;73: pubmed publisher
    ..This suggests that both phenotypically and at the genomic level ST313 isolates are evolving signatures that facilitate a systemic lifestyle in humans. ..
  27. Dong S, Xia T, Wang L, Zhao Q, Tian J. Investigation of candidate genes for osteoarthritis based on gene expression profiles. Acta Orthop Traumatol Turc. 2016;50:686-690 pubmed publisher
  28. Mokracka J, Krzyminska S, Ałtunin D, Wasyl D, Koczura R, Dudek K, et al. In vitro virulence characteristics of rare serovars of Salmonella enterica isolated from sand lizards (Lacerta agilis L.). Antonie Van Leeuwenhoek. 2018;111:1863-1870 pubmed publisher
    ..The presence of virulence-associated genes and in vitro pathogenicity assays suggest that Salmonella sp. strains originating from autochthonous, free-living lizards can potentially infect and cause disease in humans. ..
  29. Cai Q, Jeannet R, Hua W, Cook G, Zhang B, Qi J, et al. CBF?-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice. Blood. 2016;128:1503-15 pubmed publisher
    ..Abnormality in Meg/E or erythroid progenitors could potentially be considered an early predictive risk factor for leukemia evolution. ..
  30. Wittwer J, Marti Jaun J, Hersberger M. Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1. Hum Mutat. 2006;27:78-87 pubmed
    ..This may lead to an increase in ALOX15-mediated lipid metabolites, which play a role in inflammation. ..
  31. Trivedi A, Bararia D, Christopeit M, Peerzada A, Singh S, Kieser A, et al. Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination. Oncogene. 2007;26:1789-801 pubmed
    ..Thus, we report the first proteomic screen of C/EBP-interacting proteins, which identifies JNK1 as positive regulator of C/EBPalpha. ..
  32. Ramming A, Druzd D, Leipe J, Schulze Koops H, Skapenko A. Maturation-related histone modifications in the PU.1 promoter regulate Th9-cell development. Blood. 2012;119:4665-74 pubmed publisher
    ..1 expression after IL-9-inducing stimulation. Our findings identify age- and differentiation-status-related epigenetic modifications of PU.1 as a unique regulator of Th9 memory acquisition and Th9 immunity. ..
  33. Rimmelé P, Esposito M, Delestré L, Guervilly J, Ridinger Saison M, Despras E, et al. The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia. Oncotarget. 2017;8:37104-37114 pubmed publisher
    ..1-overexpressing cells. These results identify a novel pathway by which an oncogene influences replication in the absence of DNA damage. ..
  34. Ray D, Culine S, Tavitain A, Moreau Gachelin F. The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors. Oncogene. 1990;5:663-8 pubmed
    ..Spi-1 expression was detected in all the tumors examined. There was no noticeable evidence of messenger RNA alteration as compared to normal tissues. ..
  35. Tsukada J, Misago M, Serino Y, Ogawa R, Murakami S, Nakanishi M, et al. Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. Blood. 1997;90:3142-53 pubmed
  36. Rekhtman N, Radparvar F, Evans T, Skoultchi A. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 1999;13:1398-411 pubmed
    ..1. Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation. ..
  37. Andritschke D, Dilling S, Emmenlauer M, Welz T, Schmich F, Misselwitz B, et al. A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion. PLoS ONE. 2016;11:e0161965 pubmed publisher
    ..Tm. Hence, these two proteins might fulfill non-redundant functions in the pathogen-host interaction. The lack of co-localization hints to a short, direct interaction between S. Tm and SPIRE proteins or to an indirect effect. ..
  38. Liu A, Chen M, Kumar R, Stefanovic Racic M, O Doherty R, Ding Y, et al. Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4. Nat Commun. 2018;9:708 pubmed publisher
    ..Our findings raises important questions about the impact of maternal obesity and endotoxemia to fetal hematopoiesis, as fetal immune precursors are also sensitive to TLR4 signals. ..
  39. Ito T, Nishiyama C, Nakano N, Nishiyama M, Usui Y, Takeda K, et al. Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma. Int Immunol. 2009;21:803-16 pubmed publisher
    ..1 transfectants indicate that enforced PU.1 suppresses mast cell-specific gene expression through these transcription factors. ..
  40. Muirhead D, Stone M, Syrbu S. The utility of PU.1 as an immunohistochemical marker for histiocytic and dendritic lesions of the skin. Am J Dermatopathol. 2009;31:432-5 pubmed publisher
    ..PU.1 staining is easily interpreted due to the sharp nuclear staining as compared with the irregular and often variable cytoplasmic staining seen with CD68. ..
  41. Shin D, Lee C, Morse H. IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells. PLoS ONE. 2011;6:e27384 pubmed publisher
    ..We also showed that IRF8 target genes contributes to multiple aspects of the biology of mature B cells including critical components of the molecular crosstalk among GC B cells, T follicular helper cells, and follicular dendritic cells...
  42. Dluhosova M, Curik N, Vargova J, Jonasova A, Zikmund T, Stopka T. Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5. PLoS ONE. 2014;9:e87448 pubmed publisher
    ..4 Enhancer of SPI1 gene and block its expression. Our data provide new insight into complex SPI1 gene regulation now involving additional key epigenetic factors, CTCF and SMARCA5 that control PU.1 expression at the -14.4 Enhancer. ..
  43. Liu T, Wang K, Wang J, Chen D, Huang X, Ouyang P, et al. Genome Sequence of the Fish Pathogen Yersinia ruckeri SC09 Provides Insights into Niche Adaptation and Pathogenic Mechanism. Int J Mol Sci. 2016;17:557 pubmed publisher
    ..ruckeri. ..
  44. Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, et al. The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells. Immunity. 2016;45:1205-1218 pubmed publisher
    ..Importantly, Sfpi1 haploinsufficiency genetically distinguished the precursor activities of monocytes toward moDCs or microbicidal ..
  45. Buchrieser J, James W, Moore M. Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages. Stem Cell Reports. 2017;8:334-345 pubmed publisher
    ..This result makes human iPSC-derived macrophages developmentally related to and a good model for MYB-independent tissue-resident macrophages, such as alveolar and kidney macrophages, microglia, Kupffer cells, and Langerhans cells. ..
  46. Lipponen A, El Osta A, Kaspi A, Ziemann M, Khurana I, Kn H, et al. Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury. Acta Neuropathol Commun. 2018;6:17 pubmed publisher
  47. Carrere S, Verger A, Flourens A, Stehelin D, Duterque Coquillaud M. Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains. Oncogene. 1998;16:3261-8 pubmed
    ..Finally, we show that the formation of the previously described ternary complex Ergp55/Fos/jun is mediated by ETS domain and Jun protein, while the ternary complex Ergp49/Fos/Jun is mediated by Fos protein. ..
  48. Kusy S, Gault N, Ferri F, Lewandowski D, Barroca V, Jaracz Ros A, et al. Adult hematopoiesis is regulated by TIF1?, a repressor of TAL1 and PU.1 transcriptional activity. Cell Stem Cell. 2011;8:412-25 pubmed publisher
    ..These results suggest a regulation of adult hematopoiesis through TIF1?-mediated transcriptional repression of TAL1 and PU.1 target genes. ..
  49. Bheda A, Yue W, Gullapalli A, Shackelford J, Pagano J. PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells. Leuk Lymphoma. 2011;52:1336-47 pubmed publisher
    ..We propose that the ubiquitin-editing enzyme UCH L1 is a multifunctional pro-oncogenic factor involved in development and progression of certain lymphoid malignancies, including EBV-associated lymphomas. ..
  50. Elhadad D, Desai P, Grassl G, McClelland M, Rahav G, Gal Mor O. Differences in Host Cell Invasion and Salmonella Pathogenicity Island 1 Expression between Salmonella enterica Serovar Paratyphi A and Nontyphoidal S. Typhimurium. Infect Immun. 2016;84:1150-1165 pubmed publisher
    ..Paratyphi A. ..
  51. Golubeva Y, Ellermeier J, Cott Chubiz J, Slauch J. Intestinal Long-Chain Fatty Acids Act as a Direct Signal To Modulate Expression of the Salmonella Pathogenicity Island 1 Type III Secretion System. MBio. 2016;7:e02170-15 pubmed publisher
    ..Degradation of LCFAs is not required for this regulation, showing that free LCFAs serve as a cue to proper intestinal localization to invade host epithelial cells and not as a nutrient source. ..
  52. Burda P, Vargova J, Curik N, Salek C, Papadopoulos G, Strouboulis J, et al. GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia. PLoS ONE. 2016;11:e0152234 pubmed publisher
    ..1 gene transcription in human AML-EL mediated through the URE represents important mechanism that contributes to PU.1 downregulation and leukemogenesis that is sensitive to DNA demethylation therapy. ..
  53. Vergnes A, Viala J, Ouadah Tsabet R, Pocachard B, Loiseau L, Méresse S, et al. The iron-sulfur cluster sensor IscR is a negative regulator of Spi1 type III secretion system in Salmonella enterica. Cell Microbiol. 2017;19: pubmed publisher
    ..At a broader level, this model illustrates an adaptive mechanism used by bacterial pathogens to modulate their infectivity according to iron and oxygen availability. ..
  54. Yeamans C, Wang D, Paz Priel I, Torbett B, Tenen D, Friedman A. C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. Blood. 2007;110:3136-42 pubmed
    ..1(+/+), PU.1(+/-), or PU.1(+/kd) marrow myeloid progenitors but induces granulocyte lineage commitment in PU.1(kd/kd) cells lacking the PU.1 distal enhancer and does not induce either lineage in PU.1(-/-) cells. ..
  55. Kong K, Owens K, Rogers J, Mullenix J, Velu C, Grimes H, et al. MIR-23A microRNA cluster inhibits B-cell development. Exp Hematol. 2010;38:629-640.e1 pubmed publisher
    The transcription factor PU.1 (encoded by Sfpi1) promotes myeloid differentiation, but it is unclear what downstream genes are involved...
  56. Iseki Y, Nakahara M, Kubo M, Obata F, Harigae H, Takahashi S. Correlation of PU.1 and signal regulatory protein ?1 expression in PU.1 transgenic K562 cells. Int J Mol Med. 2012;29:319-23 pubmed publisher
    ..Taken together, the down-regulation of PU.1 expression suppresses the expression of SIRP?1, which may play a role in the aberrant activation of ERK in these cells. ..
  57. Yashiro T, Kasakura K, Oda Y, Kitamura N, Inoue A, Nakamura S, et al. The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c. Int Immunol. 2017;29:87-94 pubmed publisher
    ..1. Taken together, these results indicate that PU.1 functions as a positive regulator of CD11c gene expression by directly binding to the Itgax promoter and through transactivation of the Irf4 gene. ..
  58. Pongubala J, Atchison M. Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer. J Biol Chem. 1995;270:10304-13 pubmed
    ..1. The isolation of activator and repressor proteins that bind to the kappa E3'-CRE may relate to previous conflicting results concerning the role of the cAMP signal transduction pathway in kappa gene transcription. ..
  59. Zhao M, Duan X, Wen D, Chen G. PU.1, a novel caspase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells. Biochem Biophys Res Commun. 2009;382:508-13 pubmed publisher
    ..These results would provide new insights for understanding the mechanism of PU.1 protein in hematopoiesis and leukemogenesis. ..
  60. Irino T, Uemura M, Yamane H, Umemura S, Utsumi T, Kakazu N, et al. JAK2 V617F-dependent upregulation of PU.1 expression in the peripheral blood of myeloproliferative neoplasm patients. PLoS ONE. 2011;6:e22148 pubmed publisher
    ..1 is a transcription factor required for myeloid differentiation and is implicated in erythroid leukemia. Therefore, expression of PU.1 downstream of activated JAK2 may explain why JAK2 mutations are frequently observed in MPN patients. ..
  61. Dundore Arias J, Groves R, Barak J. Influence of prgH on the Persistence of Ingested Salmonella enterica in the Leafhopper Macrosteles quadrilineatus. Appl Environ Microbiol. 2015;81:6345-54 pubmed publisher
    ..This study provides novel insight into the presence and persistence of S. enterica inside M. quadrilineatus and demonstrates that the SPI-1 T3SS influences the persistence of the pathogen in the gut of a potential vector. ..
  62. Miura R, Kasakura K, Nakano N, Hara M, Maeda K, Okumura K, et al. Role of PU.1 in MHC Class II Expression via CIITA Transcription in Plasmacytoid Dendritic Cells. PLoS ONE. 2016;11:e0154094 pubmed publisher
    ..The GM-CSF-mediated up-regulation of these mRNAs was canceled in PU.1 siRNA-introduced cells. Taking these results together, we conclude that PU.1 transactivates the pIII through direct binding to Ets-motifs in the promoter in pDCs. ..
  63. Goffin V, Demonte D, Vanhulle C, De Walque S, De Launoit Y, Burny A, et al. Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity. Nucleic Acids Res. 2005;33:4285-310 pubmed
    ..Finally, we have investigated the physiological role of the HS7 binding sites in HIV-1 replication and have shown that these sites are important for viral infectivity. ..
  64. Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, et al. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood. 2011;118:6544-52 pubmed publisher
    ..1 regulatory regions, and decreased PU.1 expression. The interaction between MLL and AML1 provides a mechanism for the sequence-specific binding of MLL to DNA, and identifies RUNX1 target genes as potential effectors of MLL function. ..
  65. Li S, Valente A, Qiang M, Schlegel W, Gamez M, Clark R. Multiple PU.1 sites cooperate in the regulation of p40(phox) transcription during granulocytic differentiation of myeloid cells. Blood. 2002;99:4578-87 pubmed
    ..1 binding at multiple sites is required for p40(phox) gene transcription in myeloid cells and that granulocytic differentiation is associated with the coordinated up-regulation of PU.1 and p40(phox) expression. ..
  66. Hromas R, Orazi A, Neiman R, Maki R, Van Beveran C, Moore J, et al. Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. Blood. 1993;82:2998-3004 pubmed
    ..Thus, its expression pattern makes PU.1 a candidate for a genetic determinant of lineage commitment and stage progression in blood cell development. It also lends insight into how PU.1 might play a role in Friend virus erythroleukemia. ..
  67. Jundt F, Kley K, Anagnostopoulos I, Schulze Pröbsting K, Greiner A, Mathas S, et al. Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. Blood. 2002;99:3060-2 pubmed
    ..Our study identifies PU.1 deficiency as a recurrent defect in HRS cells that might contribute to their impairment of immunoglobulin transcription. ..
  68. Marafioti T, Mancini C, Ascani S, Sabattini E, Zinzani P, Pozzobon M, et al. Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease. Haematologica. 2004;89:957-64 pubmed
    ..Antibodies to LSP1 and PU.1 may represent useful reagents for the differential diagnosis between T-cell-rich B-cell lymphoma and lymphocyte-predominant Hodgkin's disease. ..
  69. Federzoni E, Humbert M, Valk P, Behre G, Leibundgut E, Torbett B, et al. The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients. Br J Haematol. 2013;160:855-9 pubmed publisher
  70. Wada T, Akagi T, Muraoka M, Toma T, Kaji K, Agematsu K, et al. A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency. J Immunol. 2015;195:80-6 pubmed publisher
    ..These results further support the importance of the leucine zipper domain of C/EBPε for its essential function, and indicate that multiple molecular mechanisms lead to SGD. ..
  71. Rao S, Matsumura A, Yoon J, Simon M. SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. J Biol Chem. 1999;274:11115-24 pubmed
    ..1 and harbors different transactivation domains. We conclude that SPI-B may activate unique target genes in B lymphocytes and interact with unique, although currently unidentified, cofactors. ..
  72. Lennartsson A, Pieters K, Ullmark T, Vidovic K, Gullberg U. AML-1, PU.1, and Sp3 regulate expression of human bactericidal/permeability-increasing protein. Biochem Biophys Res Commun. 2003;311:853-63 pubmed
    ..In conclusion, we provide evidence for AML-1, PU.1, and Sp3 cooperatively and directly mediating BPI-expression during myeloid differentiation. ..
  73. Cavazzini F, De Wolf Peeters C, Wlodarska I. Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphoma. Cancer Genet Cytogenet. 2005;158:167-71 pubmed
    ..These findings indicate that genomic imbalances or rearrangements are not a cause of PU.1, BOB1, and OCT2 deficiency in cHL and argue for another mechanism underlying this phenomenon. ..
  74. Gross S, Zheng J, Le A, Kerzic P, Irons R. PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34(+) hematopoietic progenitor cells. Cell Biol Toxicol. 2006;22:229-41 pubmed
    ..These results suggest that HQ induces a dysregulation in the external signals modulating PU.1 protein phosphorylation and this dysregulation may be an early event in the generation of benzene-induced AML. ..
  75. Hu Z, Gu X, Baraoidan K, Ibanez V, Sharma A, Kadkol S, et al. RUNX1 regulates corepressor interactions of PU.1. Blood. 2011;117:6498-508 pubmed publisher
    ..1 and mutated or translocated RUNX1. RUNX1 deficiency is associated with persistent corepressor interaction with PU.1. Thus, inhibiting HDAC can partly compensate for the functional consequences of RUNX1 deficiency. ..
  76. Suzuki S, Nakano H, Takahashi S. Epigenetic regulation of the metallothionein-1A promoter by PU.1 during differentiation of THP-1 cells. Biochem Biophys Res Commun. 2013;433:349-53 pubmed publisher
    ..Taken together, these findings suggest that MT-1A is epigenetically regulated by PU.1 during monocytic differentiation. ..
  77. Jego G, Lanneau D, de Thonel A, Berthenet K, Hazoume A, Droin N, et al. Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes. Leukemia. 2014;28:1676-86 pubmed publisher
    ..Taken together, HSF1 appears as a fine-tuning regulator of SPI1/PU.1 expression at the transcriptional and post-translational levels during macrophage differentiation of monocytes. ..
  78. Huskova H, Korecka K, Karban J, Vargova J, Vargova K, Dusilkova N, et al. Oncogenic microRNA-155 and its target PU.1: an integrative gene expression study in six of the most prevalent lymphomas. Int J Hematol. 2015;102:441-50 pubmed publisher
    ..Upregulation of miR-155 and downregulation of PU.1 expression are integral aspects of lymphoma biology that could mark aggressive behavior of some, but not all, lymphoma types. ..
  79. Rogers J, Owens K, Kurkewich J, Klopfenstein N, Iyer S, Simon M, et al. E2A Antagonizes PU.1 Activity through Inhibition of DNA Binding. Biomed Res Int. 2016;2016:3983686 pubmed publisher
    ..Our data suggest that E2A antagonism of PU.1 activity contributes to its ability to commit multipotential hematopoietic progenitors to the lymphoid lineages. ..
  80. Aurass P, Düvel J, Karste S, Nubel U, Rabsch W, Flieger A. glnA Truncation in Salmonella enterica Results in a Small Colony Variant Phenotype, Attenuated Host Cell Entry, and Reduced Expression of Flagellin and SPI-1-Associated Effector Genes. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..In addition to exhibiting impaired growth, the SCV showed reduced host cell entry and reduced expression of SPI-1 virulence and flagellin genes. ..
  81. Bassuk A, Anandappa R, Leiden J. Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. J Virol. 1997;71:3563-73 pubmed
    ..These interactions represent a potential target for the development of novel immunosuppressive and antiviral therapies. ..
  82. Yamamoto H, Kihara Negishi F, Yamada T, Hashimoto Y, Oikawa T. Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. Oncogene. 1999;18:1495-501 pubmed
    ..1 and other transcription factors during the process of hematopoietic cell differentiation. ..
  83. Aittomaki S, Yang J, Scott E, Simon M, Silvennoinen O. Distinct functions for signal transducer and activator of transcription 1 and PU.1 in transcriptional activation of Fc gamma receptor I promoter. Blood. 2002;100:1078-80 pubmed
    ..1 and Stat1 in FcgammaRI promoter activation, in which PU.1 appears to serve as a bridging factor with the basal transcription machinery and IFN-gamma-mediated induction of transcription occurs through recruitment of CBP/p300 by Stat1. ..
  84. Rimmelé P, Komatsu J, Hupe P, Roulin C, Barillot E, Dutreix M, et al. Spi-1/PU.1 oncogene accelerates DNA replication fork elongation and promotes genetic instability in the absence of DNA breakage. Cancer Res. 2010;70:6757-66 pubmed publisher
    ..Thus, we propose that the hitherto unsuspected role for spi-1 oncogene in promoting replication elongation and genomic mutation promotes blastic progression during leukemic development. ..
  85. Kim M, Kang J, Lee D, Bak Y, Park Y, Song Y, et al. IL-32? negatively regulates IL-1? production through its interaction with PKC? and the inhibition of PU.1 phosphorylation. FEBS Lett. 2014;588:2822-9 pubmed publisher
    ..1. Moreover, IL-32? attenuated the localization of PU.1 into the IL-1? promoter region. These findings reveal that IL-32? reduces PKC?-mediated phosphorylation of PU.1, resulting in attenuation of IL-1? production. ..
  86. Grassilli S, Nika E, Lambertini E, Brugnoli F, Piva R, Capitani S, et al. A network including PU.1, Vav1 and miR-142-3p sustains ATRA-induced differentiation of acute promyelocytic leukemia cells - a short report. Cell Oncol (Dordr). 2016;39:483-489 pubmed
    ..Since selective regulation of miRNAs may play a role in the future treatment of hematopoietic malignancies, our results may provide a basis for the development of new therapeutic strategies to restore the expression of miR-142-3p. ..
  87. Shen C, Chen M, Zhang X, Yin X, Ning H, Su R, et al. The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia. PLoS Genet. 2016;12:e1006259 pubmed publisher
    ..Our results revealed new function and mechanism of miR-22 in normal hematopoiesis and AML development and demonstrated its potential value in AML diagnosis and therapy. ..
  88. Bruce H, Barrow P, Rycroft A. Zoonotic potential of Salmonella enterica carried by pet tortoises. Vet Rec. 2017;: pubmed publisher
    ..However, it does suggest that those Salmonella strains colonising the tortoise can carry Salmonellapathogenicity island (SPI)-1 and SPI-2 conferring the potential to cause disease in human beings and other animals...
  89. Karow A, Lipp M, Schweigert E, Sengutta M, Wiltfang G, Wittmann L, et al. [Interdisciplinary Inpatient Treatment for Adolescents and Young Adults (16?-?25 Years) with Mental Illness in Adolescent Psychiatry]. Psychiatr Prax. 2017;: pubmed publisher
    ..001). Conclusion The results support the need for an interdisciplinary collaboration for the joint development of care structures in transition medicine...
  90. Hagemeier C, Bannister A, Cook A, Kouzarides T. The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc Natl Acad Sci U S A. 1993;90:1580-4 pubmed
    ..The potential for RB to influence transcription by using TFIID- and TFIIB-related functions is discussed. ..
  91. Hallier M, Lerga A, Barnache S, Tavitian A, Moreau Gachelin F. The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. J Biol Chem. 1998;273:4838-42 pubmed
    ..This effect is counterpoised in vivo by Spi-1. These data suggest that alteration of pre-mRNA alternative splicing by Spi-1 could be involved in the transformation of an erythroblastic cell. ..
  92. Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, et al. PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation. Mol Cell Biol. 2007;27:5819-34 pubmed
    ..1/PML IV/p300 complex and inhibited PU.1-induced transcription. These results suggest a novel pathogenic mechanism of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia. ..