Gene Symbol: PTPRJ
Description: protein tyrosine phosphatase, receptor type J
Alias: CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, receptor-type tyrosine-protein phosphatase eta, CD148 antigen, DEP-1, HPTP eta, R-PTP-J, density-enhanced phosphatase 1, human density enhanced phosphatase-1, protein tyrosine phosphatase, receptor type, J polypeptide, protein-tyrosine phosphatase eta, susceptibility to colon cancer 1, mouse, homolog of
Species: human
Products:     PTPRJ

Top Publications

  1. Mita Y, Yasuda Y, Sakai A, Yamamoto H, Toyooka S, Gunduz M, et al. Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers. J Cancer Res Clin Oncol. 2010;136:249-59 pubmed publisher
    ..cancers and four single nucleotide polymorphisms (SNPs), two each in two protein tyrosine phosphatase (PTP) genes, PTPRJ and PTPN13, by a case-control study conducted in Japan...
  2. Whiteford J, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman J. Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Mol Biol Cell. 2011;22:3609-24 pubmed publisher
    ..Here the protein tyrosine phosphatase receptor CD148 is shown to be a key intermediary in cell adhesion to S2ED, with downstream ?1 integrin-mediated adhesion and ..
  3. Lampugnani M, Orsenigo F, Gagliani M, Tacchetti C, Dejana E. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol. 2006;174:593-604 pubmed
    ..the contact inhibition of cell growth, whereas silencing the junction-associated density-enhanced phosphatase-1/CD148 phosphatase restores VEGFR-2 internalization and signaling...
  4. de la Fuente García M, Nicolas J, Freed J, Palou E, Thomas A, Vilella R, et al. CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes. Blood. 1998;91:2800-9 pubmed
    ..The molecule recognized by the monoclonal antibody 143-41, which has been classified as CD148 in the VI International Workshop on Leukocyte Differentiation Antigens, was immunopurified and sequenced...
  5. Lesueur F, Pharoah P, Laing S, Ahmed S, Jordan C, Smith P, et al. Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer. Hum Mol Genet. 2005;14:2349-56 pubmed
    ..The protein tyrosine phosphatase receptor type J (PTPRJ) has been recently identified as being the protein encoded by the Scc1 mouse gene (susceptibility to colon cancer-..
  6. Tarcic G, Boguslavsky S, Wakim J, Kiuchi T, Liu A, Reinitz F, et al. An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Curr Biol. 2009;19:1788-98 pubmed publisher
    ..We report the identification of PTPRK and PTPRJ (density-enhanced phosphatase-1 [DEP-1]) as EGFR-targeting phosphatases...
  7. Iuliano R, Raso C, Quintiero A, Pera I, Pichiorri F, Palumbo T, et al. The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization. J Biochem. 2009;145:377-85 pubmed publisher
    ..In this study we show the formation of different higher-order structures of the receptor-type phosphatase PTPRJ, detected in HEK293A cells transfected with different PTPRJ expression constructs...
  8. Takahashi K, Mernaugh R, Friedman D, Weller R, Tsuboi N, Yamashita H, et al. Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase. Proc Natl Acad Sci U S A. 2012;109:1985-90 pubmed publisher
    b>CD148 is a receptor-type protein tyrosine phosphatase that is expressed in several cell types, including vascular endothelial cells and duct epithelial cells...
  9. Sacco F, Tinti M, Palma A, Ferrari E, Nardozza A, Hooft van Huijsduijnen R, et al. Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. J Biol Chem. 2009;284:22048-58 pubmed publisher
    ..Overall this study provides novel insights into the anti-proliferative role of this phosphatase and proposes a new mechanism that may also be relevant for the regulation of density-dependent growth inhibition. ..

More Information


  1. Tsuboi N, Utsunomiya T, Roberts R, Ito H, Takahashi K, Noda M, et al. The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase. Biochem J. 2008;413:193-200 pubmed publisher
    b>CD148 is a transmembrane tyrosine phosphatase that has been implicated in the regulation of cell growth and transformation. However, the signalling mechanisms of CD148 are incompletely understood...
  2. Stepanek O, Kalina T, Dráber P, Skopcova T, Svojgr K, Angelisova P, et al. Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. J Biol Chem. 2011;286:22101-12 pubmed publisher
    b>CD148 is a receptor-like protein-tyrosine phosphatase known to inhibit transduction of mitogenic signals in non-hematopoietic cells...
  3. Chabot C, Spring K, Gratton J, Elchebly M, Royal I. New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival. Mol Cell Biol. 2009;29:241-53 pubmed publisher
    ..Overall, our results reveal that despite its negative role on global VEGFR2 phosphorylation, DEP-1 is a positive regulator of VEGF-mediated Src and Akt activation and endothelial cell survival. ..
  4. Lin J, Weiss A. The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol. 2003;162:673-82 pubmed
    b>CD148 is a receptor-like protein tyrosine phosphatase up-regulated on T cells after T cell receptor (TCR) stimulation. To examine the physiologic role of CD148 in TCR signaling, we used an inducible CD148-expressing Jurkat T cell clone...
  5. Palka H, Park M, Tonks N. Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J Biol Chem. 2003;278:5728-35 pubmed
    The receptor protein-tyrosine phosphatase (PTP) DEP-1 (CD148/PTP-eta) has been implicated in the regulation of cell growth, differentiation, and transformation, and most recently has been identified as a potential tumor suppressor gene ..
  6. Godfrey R, Arora D, Bauer R, Stopp S, Müller J, Heinrich T, et al. Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ. Blood. 2012;119:4499-511 pubmed publisher
    ..We recently identified the PTP DEP-1/CD148/PTPRJ as a novel negative regulator of FLT3...
  7. Kovalenko M, Denner K, Sandstrom J, Persson C, Gross S, Jandt E, et al. Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1. J Biol Chem. 2000;275:16219-26 pubmed
    ..Our study demonstrates that DEP-1 dephosphorylation of the PDGF beta-receptor is site-selective and may lead to modulation, rather than general attenuation, of signaling. ..
  8. Autschbach F, Palou E, Mechtersheimer G, Rohr C, Pirotto F, Gassler N, et al. Expression of the membrane protein tyrosine phosphatase CD148 in human tissues. Tissue Antigens. 1999;54:485-98 pubmed
    b>CD148, a receptor-like protein tyrosine phosphatase also known as HPTP-eta/DEP-1, is involved in signal transduction in leucocytes and is thought to contribute to mechanisms of cellular differentiation...
  9. Tangye S, Wu J, Aversa G, de Vries J, Lanier L, Phillips J. Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148. J Immunol. 1998;161:3803-7 pubmed
    ..b>CD148 is a receptor-type protein tyrosine phosphatase expressed by all human mononuclear cells...
  10. Tangye S, Phillips J, Lanier L, de Vries J, Aversa G. CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation. J Immunol. 1998;161:3249-55 pubmed
    ..Here, we have characterized the expression and function of CD148, a recently identified receptor-type protein tyrosine phosphatase...
  11. Arora D, Stopp S, Böhmer S, Schons J, Godfrey R, Masson K, et al. Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem. 2011;286:10918-29 pubmed publisher
    ..tested, expressed in hematopoietic cells, or presumed to be involved in oncogenesis or tumor suppression, DEP-1 (PTPRJ) was identified as a PTP negatively regulating FLT3 phosphorylation and signaling...
  12. Ostman A, Yang Q, Tonks N. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Proc Natl Acad Sci U S A. 1994;91:9680-4 pubmed
    ..The increase in DEP-1 occurs gradually with increasing cell contact and is initiated before saturation cell density is reached. These observations suggest that DEP-1 may contribute to the mechanism of contact inhibition of cell growth. ..
  13. Massa A, Barbieri F, Aiello C, Arena S, Pattarozzi A, Pirani P, et al. The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation. J Biol Chem. 2004;279:29004-12 pubmed
    ..In conclusion we propose that the expression and activation of DEP-1/PTPeta is required for somatostatin inhibition of glioma proliferation. ..
  14. Sallee J, Burridge K. Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J Biol Chem. 2009;284:14997-5006 pubmed publisher
    ..The receptor-tyrosine phosphatase DEP-1 (CD148/PTP-eta) has been implicated in cell growth and differentiation as well as in regulating phosphorylation of ..
  15. Omerovic J, Clague M, Prior I. Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells. Biochem J. 2010;426:65-72 pubmed publisher
    ..with similar potencies including PTPN2 (T-cell protein tyrosine phosphatase; also known as TC-PTP) and PTPRJ (protein tyrosine phosphatase receptor type J; also known as DEP-1/CD148)...
  16. Petermann A, Haase D, Wetzel A, Balavenkatraman K, Tenev T, Gührs K, et al. Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility. Brain Pathol. 2011;21:405-18 pubmed publisher
    DEP-1/PTPRJ is a transmembrane protein-tyrosine phosphatase which has been proposed as a suppressor of epithelial tumors...
  17. Balavenkatraman K, Jandt E, Friedrich K, Kautenburger T, Pool Zobel B, Ostman A, et al. DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. Oncogene. 2006;25:6319-24 pubmed
    ..Upregulation of DEP-1 expression, and in turn inhibition of cell growth and migration may present a previously unrecognized mechanism of chemoprevention by nutrients. ..
  18. Iuliano R, Le Pera I, Cristofaro C, Baudi F, Arturi F, Pallante P, et al. The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis. Oncogene. 2004;23:8432-8 pubmed
    ..The human homologue gene PTPRJ/DEP-1 is deleted in various tumors...
  19. Grazia Lampugnani M, Zanetti A, Corada M, Takahashi T, Balconi G, Breviario F, et al. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol. 2003;161:793-804 pubmed
    ..A dominant-negative mutant of high cell density-enhanced PTP 1 (DEP-1)//CD148 as well as reduction of its expression by RNA interference partially restore VEGFR-2 phosphorylation and MAP ..
  20. Holsinger L, Ward K, Duffield B, Zachwieja J, Jallal B. The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn). Oncogene. 2002;21:7067-76 pubmed
    The receptor-like protein tyrosine phosphatase DEP1, also known as CD148, is expressed predominantly in epithelial cells, in a variety of tumor cell lines, and in lymphocytes...
  21. Ruivenkamp C, van Wezel T, Zanon C, Stassen A, Vlcek C, Csikós T, et al. Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nat Genet. 2002;31:295-300 pubmed the positional cloning of the mouse gene Scc1 (Susceptibility to colon cancer 1) and the identification of Ptprj, encoding a receptor-type protein tyrosine phosphatase, as the underlying gene...
  22. Aya Bonilla C, Green M, Camilleri E, Benton M, Keane C, Marlton P, et al. High-resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to Non-Hodgkin's lymphoma. Genes Chromosomes Cancer. 2013;52:467-79 pubmed publisher
    ..2, containing the gene encoding the protein tyrosine phosphatase receptor type J (PTPRJ). Although PTPRJ regulates components of key survival pathways in B-cells (i.e...
  23. Karagyozov L, Godfrey R, Böhmer S, Petermann A, Hölters S, Ostman A, et al. The structure of the 5'-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation. Nucleic Acids Res. 2008;36:4443-53 pubmed publisher
    Analysis of the human protein-tyrosine phosphatase (PTP) PTPRJ mRNA detected three in-frame AUGs at the 5'-end (starting at nt +14, +191 and +356) with no intervening stop codons...
  24. Trapasso F, Yendamuri S, Dumon K, Iuliano R, Cesari R, Feig B, et al. Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo. Carcinogenesis. 2004;25:2107-14 pubmed
    DEP-1/HPTPeta, a receptor-type protein tyrosine phosphatase, is a candidate tumor suppressor gene because its expression was blocked in rat and human thyroid transformed cells, and its restoration reverted their neoplastic phenotype...
  25. Kellie S, Craggs G, Bird I, Jones G. The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation. J Cell Sci. 2004;117:609-18 pubmed
    ..These results demonstrate that DEP-1 is a negative regulator of cell proliferation, cell-substratum contacts, motility and chemotaxis in fibroblasts. ..
  26. Baker J, Majeti R, Tangye S, Weiss A. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. Mol Cell Biol. 2001;21:2393-403 pubmed
    In this study, we investigate the role of the receptor-like protein tyrosine phosphatase CD148 in T-cell activation...
  27. Gross S, Knebel A, Tenev T, Neininger A, Gaestel M, Herrlich P, et al. Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction. J Biol Chem. 1999;274:26378-86 pubmed
    ..The data support a mechanism of UV-induced signal transduction involving inactivation of PTPs through an unknown reactive intermediate that oxidizes the conserved cysteine in the active sites of PTPs. ..
  28. Arner P, Sahlqvist A, Sinha I, Xu H, Yao X, Waterworth D, et al. The epigenetic signature of systemic insulin resistance in obese women. Diabetologia. 2016;59:2393-2405 pubmed publisher
    ..related to integrin cell surface interactions and insulin signalling and included COL5A1, GAB1, IRS2, PFKFB3 and PTPRJ. In VAT there were a total of 51 differentially expressed genes (FDR 10%); 18 IR-associated genes contained a ..
  29. Althubiti M, Lezina L, Carrera S, Jukes Jones R, Giblett S, Antonov A, et al. Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death Dis. 2014;5:e1528 pubmed publisher
    ..We identified 107 proteins that could be potential markers of senescence and validated 10 of them (DEP1, NTAL, EBP50, STX4, VAMP3, ARMX3, B2MG, LANCL1, VPS26A and PLD3)...
  30. Rollin J, Pouplard C, Gratacap M, Leroux D, May M, Aupart M, et al. Polymorphisms of protein tyrosine phosphatase CD148 influence Fc?RIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia. Blood. 2012;120:1309-16 pubmed publisher
    ..b>CD148 is a protein tyrosine phosphatase that regulates Src kinases and collagen-induced platelet activation...
  31. Zierer W, Hajirezaei M, Eggert K, Sauer N, von Wirén N, Pommerrenig B. Phloem-Specific Methionine Recycling Fuels Polyamine Biosynthesis in a Sulfur-Dependent Manner and Promotes Flower and Seed Development. Plant Physiol. 2016;170:790-806 pubmed publisher
    ..Met Cycle enzymes 5-METHYLTHIORIBOSE-1-PHOSPHATE-ISOMERASE1 (MTI1) and DEHYDRATASE-ENOLASE-PHOSPHATASE-COMPLEX1 (DEP1) under different S conditions and assayed the contribution of the Met Cycle to the regeneration of S for these ..
  32. Xu Q, Zhao M, Wu K, Fu X, Liu Q. Emerging insights into heterotrimeric G protein signaling in plants. J Genet Genomics. 2016;43:495-502 pubmed publisher
    ..Recent studies have shown that the manipulation of two non-canonical G? subunits, GS3 (GRAIN SIZE 3) and DEP1 (DENSE AND ERECT PANICLE 1), represents new strategies to simultaneously increase grain yield and nitrogen use ..
  33. Davis N, Lunardi C, Shield J. Sensori-neural deafness and hypothyroidism: autoimmunity causing 'pseudo-Pendred syndrome'. Horm Res. 2006;65:267-8 pubmed
    ..Analysis for anti-DEP-1/CD148 autoantibodies described in Cogan syndrome proved positive...
  34. Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, et al. Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia. Int J Clin Exp Pathol. 2015;8:7494-8 pubmed our hospital, flow cytometry using additional markers showed that the clonal cells were CD200+(dim), CD148+(strong), and chromosome analysis revealed a complex karyotype, 47, XY, t(12;14)(p13;q32), +12, del(9p21), which ..
  35. Shimizu Y, Nagai M, Yeasmin A, Koike N, Talukdar M, Ushimaru T. Elucidation of novel budding yeast separase mutants. Biosci Biotechnol Biochem. 2016;80:473-8 pubmed publisher
    The mitotic separase cleaves Scc1 in cohesin to allow sister chromatids to separate from each other upon anaphase onset. Separase is also required for DNA damage repair...
  36. Koch S, Helbing I, Böhmer S, Hayashi M, Claesson Welsh L, Söderberg O, et al. In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions. Methods Mol Biol. 2016;1447:217-42 pubmed publisher
    ..We provide protocols suitable to monitor association of the transmembrane PTPs PTPRJ/DEP-1/CD148 and PTPRB/VE-PTP with their substrates, the receptor tyrosine kinases FMS-like tyrosine kinase 3 (FLT3/CD135), and ..
  37. Harrod T, Justement L. Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology. Immunol Res. 2002;26:153-66 pubmed
    The transmembrane protein tyrosine phosphatase CD148 is expressed on numerous cell types, including most cells of the hematopoietic lineage...
  38. Rollin J, Pouplard C, Gruel Y. Risk factors for heparin-induced thrombocytopenia: Focus on Fcγ receptors. Thromb Haemost. 2016;116:799-805 pubmed
    ..In particular, the 276P and 326Q alleles of CD148, a protein tyrosine phosphatase that regulates FcγRIIA signalling, are associated with a lower risk of HIT, and ..
  39. Spring K, Lapointe L, Caron C, Langlois S, Royal I. Phosphorylation of DEP-1/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor. Cell Signal. 2014;26:1283-93 pubmed publisher
    The protein tyrosine phosphatase DEP-1/PTPRJ positively regulates Src family kinases and critical biological functions in endothelial and hematopoietic cells...
  40. Ribeiro A, Silva R, Foyn H, Tiago M, Rathore O, Arnesen T, et al. Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion. Sci Rep. 2016;6:39118 pubmed publisher
    ..that Naa50/San is required during tissue proliferation for the correct interaction between the cohesin subunits Scc1 and Smc3...
  41. Liu Q, Han R, Wu K, Zhang J, Ye Y, Wang S, et al. G-protein βγ subunits determine grain size through interaction with MADS-domain transcription factors in rice. Nat Commun. 2018;9:852 pubmed publisher
    ..The Gγ subunits GS3 and DEP1 interact directly with the conserved keratin-like domain of MADS transcription factors, function as cofactors to ..
  42. Jayavelu A, Moloney J, Bohmer F, Cotter T. NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML. Exp Hematol. 2016;44:1113-1122 pubmed publisher
    ..STAT5 enhances expression of NOX4, ROS formation, and inactivation of the protein-tyrosine phosphatase DEP-1/PTPRJ, a negative regulator of FLT3 signaling, by reversible oxidation of its catalytic cysteine residue...
  43. Petermann A, Stampnik Y, Cui Y, Morrison H, Pachow D, Kliese N, et al. Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells. J Neurooncol. 2015;122:451-9 pubmed publisher
    ..We have previously found that loss of density enhanced phosphatase-1 (DEP-1, also designated PTPRJ), a transmembrane protein-tyrosine phosphatase, promotes meningioma cell motility and invasive growth in an ..
  44. Yeh C, Coyaud Ã, Bashkurov M, van der Lelij P, Cheung S, Peters J, et al. The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression. Curr Biol. 2015;25:2290-9 pubmed publisher
    ..This cohesion is mediated by the conserved cohesin complex comprised of SMC1, SMC3, SCC1, and either SA1 or SA2 in humans...
  45. Kim S, Ramos J, Ashikari M, Virk P, Torres E, Nissila E, et al. Development and validation of allele-specific SNP/indel markers for eight yield-enhancing genes using whole-genome sequencing strategy to increase yield potential of rice, Oryza sativa L. Rice (N Y). 2016;9:12 pubmed publisher
    ..the development of PCR-gel-based markers for eight yield-related functional genes (Gn1a, OsSPL14, SCM2, Ghd7, DEP1, SPIKE, GS5, and TGW6) to introduce yield-positive alleles from the donor lines...
  46. Fournier P, Dussault S, Fusco A, Rivard A, Royal I. Tyrosine Phosphatase PTPRJ/DEP-1 Is an Essential Promoter of Vascular Permeability, Angiogenesis, and Tumor Progression. Cancer Res. 2016;76:5080-91 pubmed publisher
    The protein tyrosine phosphatase PTPRJ/DEP-1 has been implicated in negative growth regulation in endothelial cells, where its expression varies at transitions between proliferation and contact inhibition...
  47. Sorby M, Sandstrom J, Ostman A. An extracellular ligand increases the specific activity of the receptor-like protein tyrosine phosphatase DEP-1. Oncogene. 2001;20:5219-24 pubmed
    ..These experiments identify Matrigel as a source of DEP-1 agonist(s) and provide the first evidence for upregulation of the specific activity of receptor-like protein tyrosine phosphatases by extracellular ligands. ..
  48. Li S, Yue Z, Tanaka T. Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase. Mol Cell. 2017;68:605-614.e4 pubmed publisher
    Cohesins establish sister chromatid cohesion during S phase and are removed when cohesin Scc1 is cleaved by separase at anaphase onset...
  49. Böhmer S, Weibrecht I, Söderberg O, Bohmer F. Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay. PLoS ONE. 2013;8:e62871 pubmed publisher
    ..Density-enhanced phosphatase-1 (DEP-1/PTPRJ) is a regulator of hematopoietic cell functions, and a candidate tumor suppressor...
  50. Huber R, Kulemzina I, Ang K, Chavda A, Suranthran S, Teh J, et al. Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function. Structure. 2016;24:1991-1999 pubmed publisher
    The cohesin ring, which is composed of the Smc1, Smc3, and Scc1 subunits, topologically embraces two sister chromatids from S phase until anaphase to ensure their precise segregation to the daughter cells...
  51. Billard C, Delaire S, Raffoux E, Bensussan A, Boumsell L. Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage. Blood. 2000;95:965-72 pubmed
    ..blood or tonsillar B lymphocytes induced the expression of CD100 in CD38(+)CD138(-) cell populations, including in CD148(+) subpopulations, thus expressing a memory B-cell-like phenotype...
  52. Zhang X, Tu R, Li K, Ye P, Cui X. Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer. J Cell Biochem. 2017;118:3391-3400 pubmed publisher
    b>PTPRJ is known for its antiproliferative role. Loss of heterozygosity (LOH) of PTPRJ has frequently been observed in various human cancers including colorectal cancer (CRC), lung cancer, and breast cancer...
  53. Litwin I, Bakowski T, Maciaszczyk Dziubinska E, Wysocki R. The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast. Nucleic Acids Res. 2017;45:6404-6416 pubmed publisher
    ..Here, we identify Irc5 as a novel interactor of the cohesin complex. Irc5 associates with Scc1 cohesin subunit and contributes to cohesin binding to chromatin...
  54. Toland A, Rozek L, Presswala S, Rennert G, Gruber S. PTPRJ haplotypes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17:2782-5 pubmed publisher
    ..b>Ptprj was identified as a strong candidate gene for mouse locus susceptibility to colorectal cancer 1, and one variant, ..
  55. Miguet L, Béchade G, Fornecker L, Zink E, Felden C, Gervais C, et al. Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis. J Proteome Res. 2009;8:3346-54 pubmed publisher
    ..each pathology combined to highly stringent MS validation criteria for protein identification allowed to propose CD148, a membrane receptor with phosphatase activity, as a discriminating biomarker candidate...
  56. Mekli K, Nazroo J, Marshall A, Kumari M, Pendleton N. Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing. Aging Clin Exp Res. 2016;28:413-21 pubmed publisher
    ..001198, β = 0.0894) and the Protein Tyrosine Phosphatase, Receptor type, J (PTPRJ) (rs1566729, P = 0.001372, β = 0.09397) genes...
  57. Shintani T, Higashi S, Suzuki R, Takeuchi Y, Ikaga R, Yamazaki T, et al. PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance. Sci Rep. 2017;7:11627 pubmed publisher
    ..We herein demonstrated that protein tyrosine phosphatase receptor type J (Ptprj) is expressed in hypothalamic neurons together with leptin receptors, and that PTPRJ negatively regulates leptin ..
  58. Rhodes J, Haarhuis J, Grimm J, Rowland B, Lavis L, Nasmyth K. Cohesin Can Remain Associated with Chromosomes during DNA Replication. Cell Rep. 2017;20:2749-2755 pubmed publisher cohesin, which is thought to entrap sister DNAs inside a tripartite ring composed of its Smc and kleisin (Scc1) subunits...
  59. Takahashi K, Matafonov A, Sumarriva K, Ito H, Lauhan C, Zemel D, et al. CD148 tyrosine phosphatase promotes cadherin cell adhesion. PLoS ONE. 2014;9:e112753 pubmed publisher
    b>CD148 is a transmembrane tyrosine phosphatase that is expressed at cell junctions. Recent studies have shown that CD148 associates with the cadherin/catenin complex and p120 catenin (p120) may serve as a substrate...
  60. Rocanin Arjo A, Cohen W, Carcaillon L, Frere C, Saut N, Letenneur L, et al. A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential. Blood. 2014;123:777-85 pubmed publisher
    ..These results pave the way for novel mechanistic pathways and therapeutic perspectives in the etiology of thrombin-related disorders. ..
  61. Tsoyi K, Chu S, Patino Jaramillo N, Wilder J, Villalba J, Doyle Eisele M, et al. Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    ..and proliferation by downregulating PI3K/Akt/ROCK signaling and blocking SRF binding to the ?-SMA promoter via CD148. These findings suggest that syndecan-2 has potential as an antifibrotic therapy in radiation-induced lung ..
  62. Milanowski L, Rasul F, Natalia G, Eyileten C, Siller Matula J, Postula M. Genetic variability of SRC family kinases and its association with platelet hyperreactivity and clinical outcomes: a systematic review. Curr Pharm Des. 2017;: pubmed publisher
    ..SFKs are important signal transmitters in platelets, interacting with several receptors as GPIIB/IIIa, GPIb, PEAR 1, GPIa, GPVI, PECAM and CD148.
  63. Smith N, Huffman J, Strachan D, Huang J, Dehghan A, Trompet S, et al. Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation. 2011;123:1864-72 pubmed publisher
    ..Three genes were associated with fibrin D-dimer levels. Of these 3, the F3 association was the strongest, and has not been previously reported. ..
  64. Bilotta A, Dattilo V, D Agostino S, Belviso S, Scalise S, Bilotta M, et al. A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis. Oncotarget. 2017;8:10091-10102 pubmed publisher
    b>PTPRJ is a receptor protein tyrosine phosphatase with tumor suppressor activity. Very little is known about the role of PTPRJ ectodomain, although recently both physiological and synthetic PTPRJ ligands have been identified...
  65. Lioger B, Rollin J, Vayne C, Perret Gallix K, Pouplard C, Godeau B, et al. No impact of PTPN22, PTPRJ and ACP1 genes polymorphisms on the risk of immune thrombocytopenia in French adult patients. Thromb Res. 2016;144:76-8 pubmed publisher
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    Protein Tyrosine Phosphatase Receptor J (PTPRJ) has been reported to be a tumor suppressor in various human cancers...
  67. Fan L, Miao Y, Wu Y, Wang Y, Guo R, Wang L, et al. Expression patterns of CD200 and CD148 in leukemic B-cell chronic lymphoproliferative disorders and their potential value in differential diagnosis. Leuk Lymphoma. 2015;56:3329-35 pubmed publisher
    ..We investigated CD200 and CD148 expression patterns of blood or bone marrow from 374 cases of B-CLPD by multicolor flow cytometry...
  68. Yan C, Zhao Y, Cai H, Miao G, Ma W. Blockage of PTPRJ promotes cell growth and resistance to 5-FU through activation of JAK1/STAT3 in the cervical carcinoma cell line C33A. Oncol Rep. 2015;33:1737-44 pubmed publisher
    ..In the present study, we firstly determined the expression of protein tyrosine phosphatase receptor J (PTPRJ) in 8-paired human cervical tumor and non-tumor tissues...
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    Expression of PTPRJ, which is a ubiquitous receptor-type protein tyrosine phosphatase, is significantly reduced in a vast majority of human epithelial cancers and cancer cell lines (i.e...
  70. Iuliano R, Palmieri D, He H, Iervolino A, Borbone E, Pallante P, et al. Role of PTPRJ genotype in papillary thyroid carcinoma risk. Endocr Relat Cancer. 2010;17:1001-6 pubmed publisher
    ..The gene coding for the receptor-type tyrosine phosphatase PTPRJ has been proposed as a cancer susceptibility gene, and its role as a tumor suppressor gene is well established in ..
  71. Jallal B, Mossie K, Vasiloudis G, Knyazev P, Zachwieja J, Clairvoyant F, et al. The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase. J Biol Chem. 1997;272:12158-63 pubmed
    ..These data suggest a possible mechanism of DEP-1 regulation in tumor cell lines involving serine/threonine and/or tyrosine phosphorylation. ..
  72. Honda H, Inazawa J, Nishida J, Yazaki Y, Hirai H. Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta. Blood. 1994;84:4186-94 pubmed cloning, characterization, and chromosomal localization of one of the newly identified PTPases, termed as HPTP eta (human protein-tyrosine phosphatase eta)...