Gene Symbol: PTPRB
Description: protein tyrosine phosphatase, receptor type B
Alias: HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP, receptor-type tyrosine-protein phosphatase beta, VE-PTP, protein tyrosine phosphatase, receptor type, beta polypeptide, vascular endothelial protein tyrosine phosphatase
Species: human
Products:     PTPRB

Top Publications

  1. Winderlich M, Keller L, Cagna G, Broermann A, Kamenyeva O, Kiefer F, et al. VE-PTP controls blood vessel development by balancing Tie-2 activity. J Cell Biol. 2009;185:657-71 pubmed publisher
    b>Vascular endothelial protein tyrosine phosphatase (VE-PTP) is an endothelial-specific receptor-type tyrosine phosphatase that associates with Tie-2 and VE-cadherin...
  2. Mellberg S, Dimberg A, Bahram F, Hayashi M, Rennel E, Ameur A, et al. Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. FASEB J. 2009;23:1490-502 pubmed publisher
    ..We validated the contribution of one of the identified genes, vascular endothelial protein tyrosine phosphatase (VE-PTP), to endothelial morphogenesis...
  3. Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G, et al. VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J. 2002;21:4885-95 pubmed
    ..We show here that VE-PTP (vascular endothelial protein tyrosine phosphatase), an endothelial receptor-type phosphatase, co-precipitates with VE-cadherin, but not with ..
  4. Fachinger G, Deutsch U, Risau W. Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene. 1999;18:5948-53 pubmed
    ..Based on its potential role as a regulator of blood vessel morphogenesis and maintainance, VE-PTP is a candidate gene for inherited vascular malformations similar to the Tie-2 gene. ..
  5. Peles E, Nativ M, Campbell P, Sakurai T, Martinez R, Lev S, et al. The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. Cell. 1995;82:251-60 pubmed
    ..The interaction between contactin and RPTP beta may generate unidirectional or bidirectional signals during neural development. ..
  6. Carota I, Kenig Kozlovsky Y, Onay T, Scott R, Thomson B, Souma T, et al. Targeting VE-PTP phosphatase protects the kidney from diabetic injury. J Exp Med. 2019;: pubmed publisher
    ..Expression of vascular endothelial protein tyrosine phosphatase VE-PTP (also known as PTPRB), which dephosphorylates TIE2, is robustly up-regulated in the ..
  7. Castillo Villamizar G, Nacke H, Griese L, Tabernero L, Funkner K, Daniel R. Characteristics of the First Protein Tyrosine Phosphatase with Phytase Activity from a Soil Metagenome. Genes (Basel). 2019;10: pubmed publisher
    ..966 mM). Pho16B contains the HCXXGKDR[TA]G submotif of PTP-ALPs, and it is structurally related to PtpB of Mycobacterium tuberculosis...
  8. Sens L, de Souza A, Pacheco L, Menegatti A, Mori M, Mascarello A, et al. Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors. Bioorg Med Chem. 2018;26:5742-5750 pubmed publisher
    Mycobacterium tuberculosis secretes two protein tyrosine phosphatases as virulence factors, PtpA and PtpB. Inhibition studies of these enzymes have shown significant attenuation of the M. tuberculosis growth in vivo...
  9. Hu Y, Yang C, Yang S, Cheng F, Rao J, Wang X. miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB. Cell Death Dis. 2018;9:954 pubmed publisher
    ..Tyrosine phosphatase receptor type B (PTPRB) was downregulated in HCC tissues, and was negatively correlated with miR-665 expression...

More Information


  1. Liang Y, Sun Y, Wang X, Fu E, Zhang J, Du J, et al. High electrocatalytic performance inspired by crystalline/amorphous interface in PtPb nanoplate. Nanoscale. 2018;10:11357-11364 pubmed publisher
    Nanoscale PtPb catalysts with core-shell structure have been actively explored in recent years owing to their outstanding catalytic activity...
  2. Panagopoulos I, Bjerkehagen B, Gorunova L, Berner J, Boye K, Heim S. Several fusion genes identified by whole transcriptome sequencing in a spindle cell sarcoma with rearrangements of chromosome arm 12q and MDM2 amplification. Int J Oncol. 2014;45:1829-36 pubmed publisher
    ..RNA-Seq of the primary tumor identified four fusion genes, PTGES3-PTPRB, HMGA2-DYRK2, TMBIM4-MSRB3 and USP15-CNTN1, in which all the partner genes map to the q arm of chromosome 12...
  3. Bu L, Zhang N, Guo S, Zhang X, Li J, Yao J, et al. Biaxially strained PtPb/Pt core/shell nanoplate boosts oxygen reduction catalysis. Science. 2016;354:1410-1414 pubmed
    ..We report on a class of platinum-lead/platinum (PtPb/Pt) core/shell nanoplate catalysts that exhibit large biaxial strains...
  4. Koch S, Helbing I, Böhmer S, Hayashi M, Claesson Welsh L, Söderberg O, et al. In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions. Methods Mol Biol. 2016;1447:217-42 pubmed publisher
    ..We provide protocols suitable to monitor association of the transmembrane PTPs PTPRJ/DEP-1/CD148 and PTPRB/VE-PTP with their substrates, the receptor tyrosine kinases FMS-like tyrosine kinase 3 (FLT3/CD135), and Tie2 and ..
  5. Shintani T, Higashi S, Takeuchi Y, Gaudio E, Trapasso F, Fusco A, et al. The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J Biochem. 2015;158:235-43 pubmed publisher
    ..The R3 subfamily (Ptprb, Ptprh, Ptprj and Ptpro) of receptor-like protein tyrosine phosphatases (RPTPs) is characterized by an ..
  6. Mascarello A, Chiaradia Delatorre L, Mori M, Terenzi H, Botta B. Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs. Curr Pharm Des. 2016;22:1561-9 pubmed
    ..In this context, protein tyrosine phosphatases (PtpA and PtpB) are secreted by Mtb within the host macrophage and they have been shown to contribute to Mtb pathogenicity...
  7. Alesi V, Loddo S, Grispo M, Riccio S, Montella A, Dallapiccola B, et al. Reassessment of the 12q15 deletion syndrome critical region. Eur J Med Genet. 2017;60:220-223 pubmed publisher
    ..We identified by microarray analysis a new case of 12q15 deletion. Our patient clinical features allow the refinement of the SRO to CNOT2, KCNMB4, and PTPRB genes, improving genotype-phenotype correlations.
  8. Souma T, Thomson B, Heinen S, Carota I, Yamaguchi S, Onay T, et al. Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A. 2018;115:1298-1303 pubmed publisher
    ..Here we show the endothelial-specific phosphatase VEPTP (vascular endothelial protein tyrosine phosphatase) determines TIE2 response to ANGPT2...
  9. Singhal A, Arora G, Virmani R, Kundu P, Khanna T, Sajid A, et al. Systematic Analysis of Mycobacterial Acylation Reveals First Example of Acylation-mediated Regulation of Enzyme Activity of a Bacterial Phosphatase. J Biol Chem. 2015;290:26218-34 pubmed publisher
    ..Protein-tyrosine phosphatase B (PtpB), a secretory phosphatase that regulates phosphorylation of host proteins and plays a critical role in ..
  10. Qu X, Cao Z, Zhang B, Tian X, Zhu F, Zhang Z, et al. One-pot synthesis of single-crystalline PtPb nanodendrites with enhanced activity for electrooxidation of formic acid. Chem Commun (Camb). 2016;52:4493-6 pubmed publisher
    Bimetallic PtPb nanodendrites with a single-crystalline structure were obtained by a facile one-pot strategy. The as-synthesized dendritic structure was well characterized and the growth mechanism was investigated...
  11. Huang S, Zhang L, Sung Y, Chen C, Kao Y, Agaram N, et al. Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations. Am J Surg Pathol. 2016;40:645-55 pubmed publisher
    ..Most radiation-induced AS show MYC gene amplifications, with a subset of cases harboring KDR, PTPRB, and PLCG1 mutations. Despite recent advances, the genetic abnormalities of most primary AS remain undefined...
  12. Mascarello A, Orbem Menegatti A, Calcaterra A, Martins P, Chiaradia Delatorre L, D Acquarica I, et al. Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B. Eur J Med Chem. 2018;144:277-288 pubmed publisher
    Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatases A and B (PtpA and PtpB) have been recognized as potential molecular targets for the development of new therapeutic strategies against tuberculosis (TB)...
  13. Peles E, Schlessinger J, Grumet M. Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling. Trends Biochem Sci. 1998;23:121-4 pubmed
    ..Here, the authors discuss the implications of such complexes for intercellular signaling, and the regulation of RPTP activity by cell-cell and cell-ECM contact. ..
  14. de Vries L, Li R, Ragab A, Ragab Thomas J, Chap H. Expression of a truncated protein-tyrosine phosphatase mRNA in human lung. FEBS Lett. 1991;282:285-8 pubmed
    ..reaction, we found a clone identical to but truncated at the 3'-end of the coding region of human PTPase beta (HPTP beta) mRNA. This difference in sequence is situated in the most conserved part of the catalytic domain of the enzyme...
  15. Mori M, Murata Y, Kotani T, Kusakari S, Ohnishi H, Saito Y, et al. Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins. J Cell Physiol. 2010;224:195-204 pubmed publisher
    ..These results suggest that VE-PTP, in cooperation with integrins, regulates the spreading and migration of endothelial cells during angiogenesis. ..
  16. Ishiguro H, Gong J, Hall F, Arinami T, Uhl G. Association of PTPRB gene polymorphism with drug addiction. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1167-72 pubmed publisher
    Several lines of evidence support the involvement of protein tyrosine phosphatase receptor type beta (PTPRB) in addiction...
  17. . Angiogenesis-related gene mutations drive a subset of angiosarcomas. Cancer Discov. 2014;4:OF18 pubmed publisher
    Recurrent mutations in PTPRB and PLCG1 were identified in angiosarcomas.
  18. Sun Y, Liang Y, Luo M, Lv F, Qin Y, Wang L, et al. Defects and Interfaces on PtPb Nanoplates Boost Fuel Cell Electrocatalysis. Small. 2017;: pubmed publisher
    ..Herein, a new strategy for maximizing the fuel cell catalysis by controlling/tuning the defects and interfaces of PtPb nanoplates using ion irradiation technique is reported...
  19. Wilson M, Hogstrand C, Maret W. Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase ? activity. J Biol Chem. 2012;287:9322-6 pubmed publisher
    ..Thus, for some enzymes that are not recognized as zinc metalloenzymes, zinc binding inhibits rather than activates as in classical zinc enzymes. Activation then requires removal of the inhibitory zinc. ..
  20. Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, et al. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc Natl Acad Sci U S A. 1990;87:7000-4 pubmed
  21. Yacyshyn O, Lai P, Forse K, Teichert Kuliszewska K, Jurasz P, Stewart D. Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells. Angiogenesis. 2009;12:25-33 pubmed publisher
    ..01). Hypoxia, which upregulated HPTPbeta expression in endothelial cells, impaired Ang-1-induced Tie2 phosphorylation. These results reveal a novel role for HPTPbeta in modulating Ang-1-Tie2 signaling and endothelial cell survival. ..
  22. Gaits F, Li R, Ragab A, Ragab Thomas J, Chap H. Increase in receptor-like protein tyrosine phosphatase activity and expression level on density-dependent growth arrest of endothelial cells. Biochem J. 1995;311 ( Pt 1):97-103 pubmed
    ..Of the receptor-like PTPases tested, two were exclusively expressed in HUVE cells (PTP gamma and HPTP beta)...
  23. Adamsky K, Arnold K, Sabanay H, Peles E. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. J Cell Sci. 2003;116:1279-89 pubmed
    ..These findings suggest a possible role for MAGI-3 as a scaffolding molecule that links receptor tyrosine phosphatase with its substrates at the plasma membrane. ..
  24. Peles E, Nativ M, Lustig M, Grumet M, Schilling J, Martinez R, et al. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J. 1997;16:978-88 pubmed
    ..The binding of RPTPbeta to the contactin-Caspr complex could provide a mechanism for cell-cell communication between glial cells and neurons during development. ..
  25. Garwood J, Heck N, Reichardt F, Faissner A. Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. J Biol Chem. 2003;278:24164-73 pubmed
    ..Hence, the identification of this novel isoform of phosphacan/receptor protein tyrosine phosphatase-beta provides a new component in cell-cell and cell-extracellular matrix signaling events in which these proteins have been implicated. ..
  26. Harder K, Anderson L, Duncan A, Jirik F. The gene for receptor-like protein tyrosine phosphatase (PTPRB) is assigned to chromosome 12q15-->q21. Cytogenet Cell Genet. 1992;61:269-70 pubmed
    Using a cDNA probe, the gene encoding the human receptor-like protein tyrosine phosphatase (PTPRB) was localized by an in situ hybridization to chromosome 12q15----q21.
  27. Yao Z, Darowski K, St Denis N, Wong V, Offensperger F, Villedieu A, et al. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017;65:347-360 pubmed publisher
    ..We further found that PTPRH and PTPRB directly dephosphorylate EGFR and repress its downstream signaling...
  28. Qi Y, Dai Y, Gui S. Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC. Clin Exp Pharmacol Physiol. 2016;43:1004-12 pubmed publisher
    ..However, the role of protein tyrosine phosphatase receptor type B (PTPRB) in non-small-cell lung cancer (NSCLC) tumorigenesis has not been investigated...
  29. Feito M, Bragardo M, Buonfiglio D, Bonissoni S, Bottarel F, Malavasi F, et al. gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules. Int Immunol. 1997;9:1141-7 pubmed
    ..By contrast, the observation that gp120s from four HIV-1 strains induce different CD4 association patterns suggests that gp120 directly interacts with the associating molecules, possibly via their hypervariable regions. ..
  30. Sakurai T, Lustig M, Nativ M, Hemperly J, Schlessinger J, Peles E, et al. Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. J Cell Biol. 1997;136:907-18 pubmed
    ..These results suggest that binding of glial RPTPbeta to the contactin/Nr-CAM complex is important for neurite growth and neuronal differentiation. ..
  31. Mishra R, Singh S. HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability. BMC Neurosci. 2014;15:80 pubmed publisher
    ..Unrestricted phosphorylation of junctional proteins in hBMVECs, in response to HIV-1 Tat C protein; leads to the disruption of junctional complexes and increased endothelial permeability. ..
  32. Sheth P, Watowich S. Oligomerization-induced differential dephosphorylation of c-Met receptor tyrosine kinase. Biochemistry. 2005;44:10984-93 pubmed
  33. Junker S, Maaβ S, Otto A, Michalik S, Morgenroth F, Gerth U, et al. Spectral Library Based Analysis of Arginine Phosphorylations in Staphylococcus aureus. Mol Cell Proteomics. 2018;17:335-348 pubmed publisher
    ..Hence, the deletion mutant S. aureus COL ΔptpB (protein tyrosine phosphatase B) was studied because the protein PtpB is assumed to be an arginine phosphatase...
  34. Chen H, Sun X, Ge W, Qian Y, Bai R, Zheng S. A seven-gene signature predicts overall survival of patients with colorectal cancer. Oncotarget. 2017;8:95054-95065 pubmed publisher
    ..The prognostic model of seven-gene signature (NHLRC3, ZDHHC21, PRR14L, CCBL1, PTPRB, PNPO, and PPIP5K2) was constructed and weighted by regression coefficient, which divided patients into high- and ..
  35. Krueger N, Streuli M, Saito H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 1990;9:3241-52 pubmed
    ..The cytoplasmic region of HPTP beta contains only one PTPase domain...
  36. Soady K, Tornillo G, Kendrick H, Meniel V, Olijnyk Dallis D, Morris J, et al. The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development. 2017;144:3777-3788 pubmed publisher
    b>PTPRB is a transmembrane protein tyrosine phosphatase known to regulate blood vessel remodelling and angiogenesis. Here, we demonstrate that PTPRB negatively regulates branching morphogenesis in the mouse mammary epithelium...
  37. Adamsky K, Schilling J, Garwood J, Faissner A, Peles E. Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. Oncogene. 2001;20:609-18 pubmed
    ..These results demonstrate that the FNIII domain of RPTPbeta binds to tenascin C and suggest that RPTPbeta present on glial tumor cells is a primary adhesion receptor system to the extracellular matrix. ..
  38. Kim H, Song M, Kwak I, Park T, Lim I. Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J Biol Chem. 2003;278:37497-510 pubmed
  39. Pasquali C, Curchod M, Walchli S, Espanel X, Guerrier M, Arigoni F, et al. Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. Mol Endocrinol. 2003;17:2228-39 pubmed
  40. Shen J, Frye M, Lee B, Reinardy J, McClung J, Ding K, et al. Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. J Clin Invest. 2014;124:4564-76 pubmed publisher
    ..These data support targeting VE-PTP to stabilize retinal and choroidal blood vessels and suggest that this strategy has potential for patients with a wide variety of retinal and choroidal vascular diseases. ..
  41. Dewang P, Hsu N, Peng S, Li W. Protein tyrosine phosphatases and their inhibitors. Curr Med Chem. 2005;12:1-22 pubmed
    ..Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years. ..
  42. Mantilidewi K, Murata Y, Mori M, Otsubo C, Kotani T, Kusakari S, et al. Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation. J Biol Chem. 2014;289:6451-61 pubmed publisher
    ..Our results suggest that the polarized redistribution of VE-PTP in response to SS plays an important role in the regulation of EC function by blood flow. ..
  43. Meng K, Rodriguez Pena A, Dimitrov T, Chen W, Yamin M, Noda M, et al. Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci U S A. 2000;97:2603-8 pubmed
  44. Soni D, Regmi S, Wang D, Debroy A, Zhao Y, Vogel S, et al. Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions. Am J Physiol Lung Cell Mol Physiol. 2017;312:L1003-L1017 pubmed publisher
    b>Vascular endothelial protein tyrosine phosphatase (VE-PTP) stabilizes endothelial adherens junctions (AJs) through constitutive dephosphorylation of VE-cadherin...
  45. Ratcliffe C, Qu Y, McCormick K, Tibbs V, Dixon J, Scheuer T, et al. A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta. Nat Neurosci. 2000;3:437-44 pubmed
    ..Our results define a sodium channel signaling complex containing RPTPbeta, which acts to regulate sodium channel modulation by tyrosine phosphorylation. ..
  46. Koutsioumpa M, Poimenidi E, Pantazaka E, Theodoropoulou C, Skoura A, Megalooikonomou V, et al. Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor. Mol Cancer. 2015;14:19 pubmed publisher
  47. Crossland S, Smith P, Crompton M. Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase. Biochem J. 1996;319 ( Pt 1):249-54 pubmed
    ..The fusion protein comprising both domains in tandem was also shown to dephosphorylate purified autophosphorylated epidermal growth factor receptor in vitro. ..
  48. Ramachandran C, Aebersold R, Tonks N, Pot D. Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases. Biochemistry. 1992;31:4232-8 pubmed
  49. Cheburkin I, Kniazeva T, Peter S, Kniazev I, Karelin M, Shkol nik M, et al. [Molecular portrait of human kidney carcinomas: the gene expression profiling of protein-tyrosine kinases and tyrosine phosphatases which controlled regulatory signals in the cells]. Mol Biol (Mosk). 2002;36:480-90 pubmed
    ..kidney cells included ERBB2 (HER2) for receptor protein-tyrosine kinase, several phosphatase genes (PTPRE, PTPRB, DUSP9), and EGF...
  50. Behjati S, Tarpey P, Sheldon H, Martincorena I, Van Loo P, Gundem G, et al. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet. 2014;46:376-379 pubmed publisher
    ..We identified recurrent mutations in two genes, PTPRB and PLCG1, which are intimately linked to angiogenesis...