PTPN5

Summary

Gene Symbol: PTPN5
Description: protein tyrosine phosphatase, non-receptor type 5
Alias: PTPSTEP, STEP, STEP61, tyrosine-protein phosphatase non-receptor type 5, neural-specific protein-tyrosine phosphatase, protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched), protein-tyrosine phosphatase striatum-enriched, striatal-enriched protein tyrosine phosphatase, striatum-enriched protein-tyrosine phosphatase
Species: human
Products:     PTPN5

Top Publications

  1. Cardoso A, Fernandes A, Aguilar Pimentel J, de Angelis M, Guedes J, Brito M, et al. Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Res Rev. 2018;: pubmed publisher
    ..This set of biomarkers was further expanded according to the expertise and experience of the authors. In the next step, biomarkers were assigned to six "hallmark of aging" pathways, namely (1) inflammation, (2) mitochondria and ..
  2. Li Y, Ueng K, Jeng J, Charng M, Lin T, Chien K, et al. 2017 Taiwan lipid guidelines for high risk patients. J Formos Med Assoc. 2017;116:217-248 pubmed publisher
    ..Lifestyle modification is the first step to control lipid...
  3. Veronesi M, Bolis B, Faustini M, Rota A, Mollo A. Biochemical composition of fetal fluids in at term, normal developed, healthy, viable dogs and preliminary data from pathologic littermates. Theriogenology. 2017;108:277-283 pubmed publisher
    ..normal developed, healthy and viable newborns, is necessary to depict the normal features, and represent the first step for the further detection of abnormalities associated to fetal/neonatal distress and useful for the early ..
  4. Wang X, Liu D, Zhang H, Long Y, Guan X, Qiu H, et al. [Experts consensus on the management of the right heart function in critically ill patients]. Zhonghua Nei Ke Za Zhi. 2017;56:962-973 pubmed publisher
    ..2) Right heart function management is a key step of the hemodynamic therapy in critically ill patients...
  5. Abdel Rafei M, Amin M, Hasan H. Novel effect of Daflon and low-dose ?-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats. Hum Exp Toxicol. 2016;: pubmed
    ..The cognitive and locomotor deficits were assessed via step through passive avoidance test, activity cage (actophotometer), ?-aminobutyric acid, and N-methyl-d-aspartate/..
  6. Pérez Recalde M, Ruiz Arias I, Hermida É. Could essential oils enhance biopolymers performance for wound healing? A systematic review. Phytomedicine. 2018;38:57-65 pubmed publisher
    ..In a first step, literature focusing on EO and/or mono- or sesqui-terpenoids effects in rodent wounds was identified and summarized...
  7. Jacometo C, Zhou Z, Luchini D, Corrêa M, Loor J. Maternal supplementation with rumen-protected methionine increases prepartal plasma methionine concentration and alters hepatic mRNA abundance of 1-carbon, methionine, and transsulfuration pathways in neonatal Holstein calves. J Dairy Sci. 2017;100:3209-3219 pubmed publisher
    ..striking 7-fold upregulation at d 50 versus 4 of cysteine sulfinic acid decarboxylase (CSAD), catalyzing the last step of taurine synthesis, in MET and CON calves underscores an important role of taurine during postnatal calf growth...
  8. Medrano J, Martínez Arroyo A, Sukhwani M, Noguera I, Quiñonero A, Martínez Jabaloyas J, et al. Germ cell transplantation into mouse testes procedure. Fertil Steril. 2014;102:e11-2 pubmed publisher
    To illustrate the step-by-step protocol followed to assay germ cell transplantation into the seminiferous epithelium of mouse testes. Video presentation of an animal model for research in reproductive and regenerative medicine...
  9. Bayrakdar F, Altas A, Korukluoglu G, Topal S. [Molecular diagnosis and phylogenetic analysis of the first MERS case in Turkey]. Mikrobiyol Bul. 2015;49:414-22 pubmed
    ..The reference method Superscript III One Step RT-PCR (Invitrogen, USA) recommended by World Health Organization (WHO) was also applied for confirmation...

More Information

Publications157 found, 100 shown here

  1. Mattar I, Chan M, Childs C. Factors causing acute delirium in critically ill adult patients: a systematic review. JBI Libr Syst Rev. 2012;10:187-231 pubmed
    ..A three-step search strategy was utilised in this review. An initial limited search of MEDLINE and CINAHL was undertaken...
  2. Valadez Caballero D, González Santamaría R, Soto Mendoza H, Alberto Blanco Figueroa J, Flores Pantoja J. [Choledocholithiasis and pregnancy. Hybrid laparo-endoscopic treatment in one step]. Cir Cir. 2014;82:188-94 pubmed
    ..Current evidence has shown that the combined use of laparoscopy and therapeutic endoscopic cholangiography in one step is effective for the treatment of choledocholithiasis, decreasing the risk of complications associated with ..
  3. Spetea M. Opioid receptors and their ligands in the musculoskeletal system and relevance for pain control. Curr Pharm Des. 2013;19:7382-90 pubmed
    ..Demonstration of the occurrence of an endogenous opioid system in bone and joint tissues represents an essential step for defining novel pharmacological strategies to attain peripheral control of pain in musculoskeletal disorders.
  4. Kurmanbayeva A, Brychkova G, Bekturova A, Khozin I, Standing D, Yarmolinsky D, et al. Determination of Total Sulfur, Sulfate, Sulfite, Thiosulfate, and Sulfolipids in Plants. Methods Mol Biol. 2017;1631:253-271 pubmed publisher
    ..Cysteine also acts as the sulfur donor for the sulfuration of the molybdenum cofactor, crucial for the last step of ABA biosynthesis...
  5. Tümtürk A, Kaya Ozcora G, Kaçar Bayram A, Kabaklioglu M, Doganay S, Canpolat M, et al. Torticollis in children: an alert symptom not to be turned away. Childs Nerv Syst. 2015;31:1461-70 pubmed publisher
    ..The first step should be always a careful and complete physical examination, which must include all systems...
  6. Jakobsen J, Nielsen E, Feinberg J, Katakam K, Fobian K, Hauser G, et al. Direct-acting antivirals for chronic hepatitis C. Cochrane Database Syst Rev. 2017;6:CD012143 pubmed publisher
    ..We systematically assessed risks of bias, performed Trial Sequential Analysis, and followed an eight-step procedure to assess thresholds for statistical and clinical significance...
  7. Na J, Jung J, Bang J, Lu Q, Carlson B, Guo X, et al. Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation. Free Radic Biol Med. 2018;: pubmed publisher
    ..In the first step, ATP is hydrolyzed to produce ADP and gamma-phosphate...
  8. Moawad G, Tyan P, Abi KhalIL E, Samuel D, Obias V. Multidisciplinary Resection of Deeply Infiltrative Endometriosis. J Minim Invasive Gynecol. 2018;25:389-390 pubmed publisher
    ..A technical video showing a step-by-step approach for the resection of deeply infiltrative endometriosis (Canadian Task Force classification level ..
  9. Kemp M, Molloy T, Usuda H, Woodward E, Miura Y, Payne M, et al. Outside-in? Acute fetal systemic inflammation in very preterm chronically catheterized sheep fetuses is not driven by cells in the fetal blood. Am J Obstet Gynecol. 2016;214:281.e1-281.e10 pubmed publisher
    ..at <32 weeks gestation; understanding how the fetus responds to proinflammatory insult will be an important step towards early preterm birth prevention...
  10. Pirtea L, Balint O, Secoşan C, Grigoraş D, Ilina R. Laparoscopic Resection of Cesarean Scar Ectopic Pregnancy after Unsuccessful Systemic Methotrexate Treatment. J Minim Invasive Gynecol. 2018;: pubmed publisher
    ..0 Vicryl (Ethicon Inc., Cincinnati, OH). We used methylene blue to verify the tightness of the suture. The final step was the removal of the clips. The operative time was 85 minutes with minimal blood loss of about 20 mL...
  11. Bozzacco L, Yi Z, Andreo U, Conklin C, Li M, Rice C, et al. Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication. J Virol. 2016;90:3212-28 pubmed publisher
    ..future studies to address similarities and/or differences among flaviviruses and to interrogate the precise mechanisms employed for polyprotein processing, a critical step that can ultimately be targeted for novel drug development.
  12. Zoccola E, Delamare Deboutteville J, Barnes A. Identification of Barramundi (Lates calcarifer) DC-SCRIPT, a Specific Molecular Marker for Dendritic Cells in Fish. PLoS ONE. 2015;10:e0132687 pubmed publisher
    Antigen presentation is a critical step bridging innate immune recognition and specific immune memory...
  13. Nynca J, Dietrich M, Adamek M, Steinhagen D, Bilinska B, Hejmej A, et al. Purification, characterization and expression of transferrin from rainbow trout seminal plasma. Comp Biochem Physiol B Biochem Mol Biol. 2017;208-209:38-46 pubmed publisher
    ..An efficient, original three-step isolation procedure for TF consisting in hydrophobic interaction chromatography, gel filtration and preparative ..
  14. Sierra N, Folio C, Robert X, Long M, Guillon C, Alvarez G. Looking for Novel Capsid Protein Multimerization Inhibitors of Feline Immunodeficiency Virus. Pharmaceuticals (Basel). 2018;11: pubmed publisher
    ..The FIV capsid protein (CA) drives the assembly of the viral particle, which is a critical step in the viral replication cycle...
  15. Garcia C, Depoix D, Queiroz R, Souza J, Fontes W, de Sousa M, et al. Dynamic molecular events associated to Plasmodium berghei gametogenesis through proteomic approach. J Proteomics. 2018;180:88-98 pubmed publisher
    ..The sexual reproduction is a key step of Plasmodium life cycle and constitutes an attractive target for the development of new therapeutic approaches ..
  16. Sharon J, Trevino C, Schubert M, Carey J. Treatment of Menière's Disease. Curr Treat Options Neurol. 2015;17:341 pubmed publisher
    ..Medical therapy with a diuretic is the usual next step. If that fails to control symptoms, then the options of intratympanic (IT) steroids and betahistine are discussed...
  17. Luo Y, Kuang S, Xue L, Yang J. The mechanism of 5-lipoxygenase in the impairment of learning and memory in rats subjected to chronic unpredictable mild stress. Physiol Behav. 2016;167:145-153 pubmed publisher
    ..Sucrose preference tests were performed to assess depression-like behavior. The Morris water maze and step-down tests were used to evaluate learning and memory performance...
  18. Wei J, Damania A, Gao X, Liu Z, Mejia R, Mitreva M, et al. The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates. Parasit Vectors. 2016;9:518 pubmed
    ..ceylanicum provides useful information for the identification of proteins involved in the blood-feeding process, representing a first step towards a reverse vaccinology approach to a human hookworm vaccine.
  19. Miller M, Sorkin J, Mastella L, Sutherland A, Rhyne J, Donnelly P, et al. Poly is more effective than monounsaturated fat for dietary management in the metabolic syndrome: The muffin study. J Clin Lipidol. 2016;10:996-1003 pubmed publisher
    ..group design with randomization to a hypocaloric MUFA or PUFA-enriched diet after weight stabilization on an AHA step I diet...
  20. Dammacco R. Systemic lupus erythematosus and ocular involvement: an overview. Clin Exp Med. 2018;18:135-149 pubmed publisher
    ..A thorough ophthalmological control is strongly recommended at closer intervals for all SLE patients, in step with the total length of exposure to the drugs and the cumulative dose administered.
  21. Khan A, Saleemi M, Ali F, Abubakar M, Hussain R, Abbas R, et al. Pathophysiology of peste des petits ruminants in sheep (Dorper & Kajli) and goats (Boer & Beetal). Microb Pathog. 2018;117:139-147 pubmed publisher
    ..One-Step RT-PCR using NP3 and NP4 primers confirmed a PPR virus of 352 bp size in spleen, lungs and mesenteric and brachial ..
  22. Volonte C, Apolloni S, Parisi C. MicroRNAs: newcomers into the ALS picture. CNS Neurol Disord Drug Targets. 2015;14:194-207 pubmed
    ..primary transcripts, they are exported to the cytoplasm and further modified to obtain the mature miRNAs, with each step of their biogenesis being a potential step of regulation...
  23. Sittner A, Bar David E, Glinert I, Ben Shmuel A, Weiss S, Schlomovitz J, et al. Pathology of wild-type and toxin-independent Bacillus anthracis meningitis in rabbits. PLoS ONE. 2017;12:e0186613 pubmed publisher
    ..Herein, we propose that the first step of anthrax-meningitis is bacterial adhesion to the blood vessels by manipulating coagulation, mainly in the choroid ..
  24. Wu X, Jiang L, Yu M, An X, Ma R, Yu Z. Proteomic analysis of changes in mitochondrial protein expression during peach fruit ripening and senescence. J Proteomics. 2016;147:197-211 pubmed publisher
    Ripening and senescence define the last step of fruit development, which directly affects its commercial value, and mitochondria play a crucial role in these processes...
  25. Veluchamy A, Rastogi A, Lin X, Lombard B, Murik O, Thomas Y, et al. An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum. Genome Biol. 2015;16:102 pubmed publisher
    ..The work represents an important initial step for understanding the evolutionary history of chromatin and how epigenetic modifications affect gene expression in ..
  26. Phan T, Tran L, Schumann W, Nguyen H. Development of Pgrac100-based expression vectors allowing high protein production levels in Bacillus subtilis and relatively low basal expression in Escherichia coli. Microb Cell Fact. 2015;14:72 pubmed publisher
    ..of recombinant genes to strong inducible promoters allowing intracellular expression in Bacillus subtilis is a two-step process...
  27. Filhol O, Giacosa S, Wallez Y, Cochet C. Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity. Cell Mol Life Sci. 2015;72:3305-22 pubmed publisher
    ..studies reported its implication in the regulation of the epithelial-to-mesenchymal transition (EMT), an early step in cancer invasion and metastasis...
  28. Zscharnack M, Krause C, Aust G, Thümmler C, Peinemann F, Keller T, et al. Preclinical good laboratory practice-compliant safety study to evaluate biodistribution and tumorigenicity of a cartilage advanced therapy medicinal product (ATMP). J Transl Med. 2015;13:160 pubmed publisher
    ..The testing strategy addresses biodistribution and tumorigenicity using a multi-step analysis without any cell manipulation to exclude changes of test item characteristics...
  29. Xiong P, Wang R, Zhang X, DeLa Torre E, Leon F, Zhang Q, et al. Design, Synthesis, and Evaluation of Genistein Analogues as Anti-Cancer Agents. Anticancer Agents Med Chem. 2015;15:1197-203 pubmed
    ..Eight genistein analogues have been successfully synthesized with Suzuki-Miyaura coupling reaction as a key step. Their in vitro anti-cancer potential was evaluated by trypan blue exclusion assay and WST-1 cell proliferation ..
  30. De Waelheyns E, Segers K, Sardis M, Anné J, Nicolaes G, Economou A. Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening. J Antibiot (Tokyo). 2015;68:666-73 pubmed publisher
    ..against a predicted druggable pocket in the preprotein-binding domain of Escherichia coli SecA using a multi-step virtual ligand screening protocol...
  31. Yamini T, Nichter M, Nichter M, Sairu P, Aswathy S, Leelamoni K, et al. Developing a fully integrated tobacco curriculum in medical colleges in India. BMC Med Educ. 2015;15:90 pubmed publisher
    ..The curriculum has been adopted by the state of Kerala as a first step to gaining Medical Council of India review and possible recognition.
  32. Watanabe M, Watanabe T, Yabuki M, Tamai I. Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys. Drug Metab Pharmacokinet. 2015;30:198-204 pubmed publisher
    ..sulfate (DHEAS), an endogenous OATP substrate, in predicting OATP-mediated DDI in cynomolgus monkeys as a first step toward in human assessment...
  33. Bukvareva E, Grunewald K, Bobylev S, Zamolodchikov D, Zimenko A, Bastian O. The current state of knowledge of ecosystems and ecosystem services in Russia: A status report. Ambio. 2015;44:491-507 pubmed publisher
    ..As a first step, a methodology for assessing the services for the federal subjects of Russia was chosen, i.e...
  34. Dykeman E. An implementation of the Gillespie algorithm for RNA kinetics with logarithmic time update. Nucleic Acids Res. 2015;43:5708-15 pubmed publisher
    ..that many of the base-pair addition/deletion reactions and their corresponding rates do not change between each step in the algorithm...
  35. Ridolo E, Montagni M, Bonzano L, Savi E, Peveri S, Costantino M, et al. How far from correct is the use of adrenaline auto-injectors? A survey in Italian patients. Intern Emerg Med. 2015;10:937-41 pubmed publisher
    ..The correct use was verified by the physician using a trainer with a four-step examination...
  36. Souvignet J, Rodrigues J. Toward a patient safety upper level ontology. Stud Health Technol Inform. 2015;210:160-4 pubmed
    ..This alignment is a big step in the top-down approach, to build a complete and standardized domain ontology in order to facilitate the basis to ..
  37. Zhang W, Wang Y, Zhang D, Yu S, Zhu W, Wang J, et al. A one-step approach to the large-scale synthesis of functionalized MoS2 nanosheets by ionic liquid assisted grinding. Nanoscale. 2015;7:10210-7 pubmed publisher
    ..Here we report one-step synthesis and surface functionalization of MoS2 nanosheets by a facile ionic liquid assisted grinding method in the ..
  38. Kamdar B, Shah P, Sakamuri S, Kamdar B, Oh J. A NOVEL SEARCH BUILDER TO EXPEDITE SEARCH STRATEGIES FOR SYSTEMATIC REVIEWS. Int J Technol Assess Health Care. 2015;31:51-3 pubmed publisher
    ..0 also allows for searches to be easily shared and saved for future reference. This novel, user-friendly tool can save considerable time and streamline a cumbersome step in the systematic review process.
  39. Fernando W, Martins I, Goozee K, Brennan C, Jayasena V, Martins R. The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. Br J Nutr. 2015;114:1-14 pubmed publisher
    ..found in coconut may assist in preventing the aggregation of amyloid-β peptide, potentially inhibiting a key step in the pathogenesis of AD...
  40. Haugland H, Rehn M, Klepstad P, Kruger A. Developing quality indicators for physician-staffed emergency medical services: a consensus process. Scand J Trauma Resusc Emerg Med. 2017;25:14 pubmed publisher
    ..A four-step modified nominal group technique process (expert panel method) was used...
  41. Brown F, Wyckoff J. Application of One-Step IADPSG Versus Two-Step Diagnostic Criteria for Gestational Diabetes in the Real World: Impact on Health Services, Clinical Care, and Outcomes. Curr Diab Rep. 2017;17:85 pubmed publisher
    This paper seeks to summarize the impact of the one-step International Association of Diabetes and Pregnancy Study Groups (IADPSG) versus the two-step gestational diabetes mellitus (GDM) criteria with regard to prevalence, outcomes, ..
  42. Xia P, Quan G, Yang Y, Zhao J, Wang Y, Zhou M, et al. Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae. Vet Res. 2018;49:23 pubmed publisher
    ..Escherichia coli (ETEC) and the specific receptor on porcine intestinal epithelial cells is the initial step in F4+ ETEC infection...
  43. Liu R, Cui J, Liu X, Jiang P, Sun G, Zhang X, et al. Comparative proteomic analysis of surface proteins of Trichinella spiralis muscle larvae and intestinal infective larvae. Acta Trop. 2015;150:79-86 pubmed publisher
    The critical step for Trichinella spiralis infection is that muscle larvae (ML) are activated to intestinal infective larvae (IIL) and invade intestinal epithelium to further develop...
  44. Niewiadomski J, Zhou J, Roman H, Liu X, Hirschberger L, Locasale J, et al. Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Ann N Y Acad Sci. 2016;1363:99-115 pubmed publisher
    ..Cysteine dioxygenase (CDO) catalyzes the first step of the major pathway for cysteine catabolism...
  45. Lhotský O, Krákorová E, Mašín P, Žebrák R, Linhartová L, Křesinová Z, et al. Pharmaceuticals, benzene, toluene and chlorobenzene removal from contaminated groundwater by combined UV/H2O2 photo-oxidation and aeration. Water Res. 2017;120:245-255 pubmed publisher
    ..The results showed that UV/H2O2 was an efficient and necessary step for degradation of the pharmaceuticals; however, the monoaromatics were already removed during the aeration step...
  46. Hernandez F, Jitaru P, Cormant F, Noël L, Guérin T. Development and application of a method for Cr(III) determination in dairy products by HPLC-ICP-MS. Food Chem. 2018;240:183-188 pubmed publisher
    ..The extraction step was optimised by using an experimental design. A limit of quantification of 38µgkg-1dry weight (d.w...
  47. Cook O, Nusstein J, Drum M, Fowler S, Reader A, Draper J. Anesthetic Efficacy of a Combination of 4% Prilocaine/2% Lidocaine with Epinephrine for the Inferior Alveolar Nerve Block: A Prospective, Randomized, Double-blind Study. J Endod. 2018;44:683-688 pubmed publisher
    ..deposition were analyzed using multiple Wilcoxon matched pairs signed rank tests; both were adjusted using the step-down Bonferroni method of Holm...
  48. Wolitzky Taylor K, Zimmermann M, Arch J, De Guzman E, Lagomasino I. Has evidence-based psychosocial treatment for anxiety disorders permeated usual care in community mental health settings?. Behav Res Ther. 2015;72:9-17 pubmed publisher
    ..Understanding usual care delivery patterns is an important preliminary step to identifying and addressing barriers to optimal anxiety disorder treatment in adult community mental health ..
  49. Hermansen K, Bohl M, Schioldan A. Insulin Aspart in the Management of Diabetes Mellitus: 15 Years of Clinical Experience. Drugs. 2016;76:41-74 pubmed publisher
    ..Studies have demonstrated that step-wise addition of insulin aspart is a viable intensification option for patients with type 2 diabetes failing on ..
  50. Kong X, Song Y, Zhen Z, Liu J. Genetic Variation in S100B Modulates Neural Processing of Visual Scenes in Han Chinese. Cereb Cortex. 2017;27:1326-1336 pubmed publisher
    ..Our study takes the first step toward understanding the neurogenetic mechanism of human spatial navigation and suggests a novel approach to ..
  51. Burghardt T, Ajtai K, Sun X, Takubo N, Wang Y. In vivo myosin step-size from zebrafish skeletal muscle. Open Biol. 2016;6: pubmed publisher
    ..Consecutive frame lever-arm angular displacement converts to step-size by its product with the estimated lever-arm length...
  52. Hernández Vega J, Cady B, Kayanja G, Mauriello A, Cervantes N, Gillespie A, et al. Detoxification of polycyclic aromatic hydrocarbons (PAHs) in Arabidopsis thaliana involves a putative flavonol synthase. J Hazard Mater. 2017;321:268-280 pubmed publisher
    ..Bioremediation studies with bacteria have led to the identification of dioxygenases (DOXs) in the first step to degrade these recalcitrant compounds...
  53. Faux P, Druet T. A strategy to improve phasing of whole-genome sequenced individuals through integration of familial information from dense genotype panels. Genet Sel Evol. 2017;49:46 pubmed publisher
    Haplotype reconstruction (phasing) is an essential step in many applications, including imputation and genomic selection. The best phasing methods rely on both familial and linkage disequilibrium (LD) information...
  54. Wang X, Song D, Wang B, Yang J, Ge L, Zhao L, et al. A mutant of hydrophobin HGFI tuning the self-assembly behaviour and biosurfactant activity. Appl Microbiol Biotechnol. 2017;101:8419-8430 pubmed publisher
    ..Pichia pastoris GS115 was used for recombinant expression of the ME24 mutant, which was purified by a two-step procedure. The function of the mutated residue in HGFI self-assembly was investigated...
  55. Soltan M, Wilkes R, Elsheery M, Elhaig M, Riley M, Kennedy M. Circulation of bovine viral diarrhea virus--1 (BVDV-1) in dairy cattle and buffalo farms in Ismailia Province, Egypt. J Infect Dev Ctries. 2015;9:1331-7 pubmed publisher
    ..A total of 298 blood samples were collected and tested using an optimized one-step, real-time multiplex Taqman-based RT-PCR...
  56. Ansari H, Ellison N, Bassett S, Hussain S, Bryan G, Williams W. Fluorescence chromosome banding and FISH mapping in perennial ryegrass, Lolium perenne L. BMC Genomics. 2016;17:977 pubmed
    ..perenne, thus providing a step towards integration of the genetic and cytogenetic maps...
  57. Ängeby Möller K, Svärd H, Suominen A, Immonen J, Holappa J, Stenfors C. Gait analysis and weight bearing in pre-clinical joint pain research. J Neurosci Methods. 2018;300:92-102 pubmed publisher
    ..Gait parameters such as amount of normal step sequences, walking speed and duration of step placement were also affected...
  58. Menotta M, Biagiotti S, Orazi S, Rossi L, Chessa L, Leuzzi V, et al. In vivo effects of dexamethasone on blood gene expression in ataxia telangiectasia. Mol Cell Biochem. 2018;438:153-166 pubmed publisher
    ..These results provide useful information and represent a first step towards gaining a better understanding of the underlying mechanisms of the effects of dexamethasone on AT patients.
  59. Li J, Yuan X, Zhao H, Li F, Lei Z, Zhang Z. Highly efficient one-step advanced treatment of biologically pretreated coking wastewater by an integration of coagulation and adsorption process. Bioresour Technol. 2018;247:1206-1209 pubmed publisher
    ..Results of laboratory, pilot, and industrial-scale experiments indicated that this one-step novel process can remove biorefractory pollutants, achieving the maximum chemical oxygen demand (COD) and cyanide ..
  60. Solá Gutiérrez C, San Román M, Ortiz I. Fate and hazard of the electrochemical oxidation of triclosan. Evaluation of polychlorodibenzo‑p‑dioxins and polychlorodibenzofurans (PCDD/Fs) formation. Sci Total Environ. 2018;626:126-133 pubmed publisher
    ..As expected, complete degradation of TCS was achieved in all the studied conditions; however, going a step further and knowing that TCS is a precursor of polychlorinated dibenzo‑p‑dioxins and dibenzofurans (..
  61. Misik J, Korabecny J, Nepovimova E, Kracmarova A, Kassa J. Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats--Is there a potential for Alzheimer's disease treatment?. Neurosci Lett. 2016;612:261-268 pubmed publisher
    ..Male Wistar rats were subjected to tests of learning and memory in a water maze and step-through passive avoidance task...
  62. Alqahtani M, Grieu F, Carrello A, Amanuel B, Mashour M, Alattas R, et al. Screening for Lynch Syndrome in Young Colorectal Cancer Patients from Saudi Arabia Using Microsatellite Instability as the Initial Test. Asian Pac J Cancer Prev. 2016;17:1917-23 pubmed
    ..Our aim here was to screen young CRC patients for MSI as a first step in the identification of unrecognized cases of LS in the Saudi population...
  63. Deleo F, Kobayashi S, Porter A, Freedman B, Dorward D, Chen L, et al. Survival of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 in Human Blood. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Thus, it is imperative that we gain a better understanding of host defense against this pathogen as a step toward developing novel therapies...
  64. Bianchi D, Monaldo E, Gizzi A, Marino M, Filippi S, Vairo G. A FSI computational framework for vascular physiopathology: A novel flow-tissue multiscale strategy. Med Eng Phys. 2017;47:25-37 pubmed publisher
    ..an explicit time-marching approach, able to accurately describe tissue nonlinearities within each computational step for the fluid problem...
  65. Yamaguchi M, Chibana H. A Method for Obtaining Serial Ultrathin Sections of Microorganisms in Transmission Electron Microscopy. J Vis Exp. 2018;: pubmed publisher
    ..In this paper, we show a step-by-step procedure for safely obtaining serial ultrathin sections of microorganisms...
  66. Siu B, Tsang M, Lee V, Liu A, Tse S, Luk H, et al. Pathway to mental health recovery: a qualitative and quantitative study on the needs of Chinese psychiatric inpatients. BMC Psychiatry. 2016;16:236 pubmed publisher
    Exploration of the information and participation needs of psychiatric inpatients is an important step for the implementation of recovery-oriented mental health service...
  67. Haines B, Kawakami T, Kuwata K, Murakami K, Itami K, Musaev D. Cu-Catalyzed aromatic C-H imidation with N-fluorobenzenesulfonimide: mechanistic details and predictive models. Chem Sci. 2017;8:988-1001 pubmed publisher
    ..The calculated KIE for the turnover-limiting SET1 step reproduces its experimentally observed value...
  68. Guo S, Yuan P, Zhang J, Jin P, Sun H, Lei K, et al. Atomic-scaled cobalt encapsulated in P,N-doped carbon sheaths over carbon nanotubes for enhanced oxygen reduction electrocatalysis under acidic and alkaline media. Chem Commun (Camb). 2017;53:9862-9865 pubmed publisher
    A one-step in situ nanoconfined pyrolysis strategy was developed to anchor highly active single Co atoms on the P,N-doped porous carbon@carbon nanotube coaxial nanocables (Co-P,N-CNT), which exhibit remarkable enhanced ORR ..
  69. Sapkota K, Huang F. Efficient one-pot enzymatic synthesis of dephospho coenzyme A. Bioorg Chem. 2018;76:23-27 pubmed publisher
    ..We hereby describe a simple and efficient enzymatic synthesis of depCoA in a single-step from commercially available and inexpensive oxidized pantethine (Ox-Pan) and ATP...
  70. Merkord C, Liu Y, Mihretie A, Gebrehiwot T, Awoke W, Bayabil E, et al. Integrating malaria surveillance with climate data for outbreak detection and forecasting: the EPIDEMIA system. Malar J. 2017;16:89 pubmed publisher
    ..Successful implementation and use of EPIDEMIA is an important step forward in the use of epidemiological and environmental informatics systems for malaria surveillance...
  71. Tiwari S, Pathak P, Pratap Singh K, Sagar R. One-pot two-step facile synthesis of 2,3,4,5-tetra substituted dihydrooxazoles and their antimicrobial activity. Bioorg Med Chem Lett. 2017;27:3802-3805 pubmed publisher
    ..Compounds 4b, 4d, 4f, 4i, 4k and 4m, have shown good antibacterial activity whereas compounds 4e, 4g, 4h, 4j, 4l and 4n have displayed better antifungal activity. ..
  72. Zhou N, Wu Y, Su T, Zhang L, Yin K, Zheng D, et al. Course constructions: A case-base of forensic toxicology. J Forensic Leg Med. 2017;50:36-38 pubmed publisher
    ..at Zhongshan School of Medicine began to construct top-quality courses in forensic toxicology, with its first step, creating a base containing typical cases of intoxication...
  73. Markopoulos G, Roupakia E, Tokamani M, Chavdoula E, Hatziapostolou M, Polytarchou C, et al. A step-by-step microRNA guide to cancer development and metastasis. Cell Oncol (Dordr). 2017;40:303-339 pubmed publisher
    ..The role of specific tumor-derived exosomes containing miRNAs and their use as biomarkers in diagnosis and prognosis, and as therapeutic targets, are also discussed. ..
  74. Kadam S, Alvarez C, Tiwari B, O Donnell C. Extraction and characterization of protein from Irish brown seaweed Ascophyllum nodosum. Food Res Int. 2017;99:1021-1027 pubmed publisher
    ..to be the most efficient method of extraction among all methods investigated (59% of recovery); followed by single step of alkali extraction assisted with ultrasound (68.4?m) which was able to extract 57% of total protein...
  75. Kwiatkowski da Silva A, Ponge D, Peng Z, Inden G, Lu Y, Breen A, et al. Phase nucleation through confined spinodal fluctuations at crystal defects evidenced in Fe-Mn alloys. Nat Commun. 2018;9:1137 pubmed publisher
    ..are known precursor states to nucleation and phase transition; however, nucleation remains the less well-understood step in the complete thermodynamic sequence that shapes a microstructure...
  76. Pérez E, Lichtenstein M, Suñol C, Casañ Pastor N. Coatings of nanostructured pristine graphene-IrOx hybrids for neural electrodes: Layered stacking and the role of non-oxygenated graphene. Mater Sci Eng C Mater Biol Appl. 2015;55:218-26 pubmed publisher
    ..The fully straightforward electrochemical exfoliation and electrodeposition constitutes a step towards the application of graphene in biomedical systems, expanding the knowledge of pristine graphene vs...
  77. Ribeiro R, Antillon F, Pedrosa F, Pui C. Global Pediatric Oncology: Lessons From Partnerships Between High-Income Countries and Low- to Mid-Income Countries. J Clin Oncol. 2016;34:53-61 pubmed publisher
    ..First, an essential step is provision of treatment regardless of ability to pay...
  78. Petrova A, Smith C. Application of Brown Planthopper Salivary Gland Extract to Rice Plants Induces Systemic Host mRNA Patterns Associated with Nutrient Remobilization. PLoS ONE. 2015;10:e0141769 pubmed publisher
    ..To validate SSH library results, six genes were further analyzed by One-Step Real-Time Reverse Transcriptase-PCR...
  79. Johler S, Zurfluh K, Stephan R. Tracing and inhibiting growth of Staphylococcus aureus in barbecue cheese production after product recall. J Dairy Sci. 2016;99:3345-3350 pubmed publisher
    ..To this end, we traced Staph. aureus in a step-wise blinded process analysis on 4 different production days using spa (Staphylococcus protein A gene) typing, DNA ..
  80. Park S, Shin Y, Seo J, Song J, Yang H. A highly sensitive and simply operated protease sensor toward point-of-care testing. Analyst. 2016;141:2481-6 pubmed publisher
    ..which is obtained using (i) low nonspecific adsorption, (ii) high signal-to-background ratio, and (iii) one-step solution treatment...
  81. Car J, Tan W, Huang Z, Sloot P, Franklin B. eHealth in the future of medications management: personalisation, monitoring and adherence. BMC Med. 2017;15:73 pubmed publisher
    ..eHealth offers opportunities to transform every step of the patient's medicines management journey...
  82. Ratautas D, Tetianec L, Marcinkevičienė L, Meškys R, Kulys J. Bioanode with alcohol dehydrogenase undergoing a direct electron transfer on functionalized gold nanoparticles for an application in biofuel cells for glycerol conversion. Biosens Bioelectron. 2017;98:215-221 pubmed publisher
    ..This electrode catalysed the oxidation of both glycerol and glyceraldehyde thus demonstrating a consecutive two-step process. The bioanode generated the current density of 510µAcm-2 at pH 7.0 and 0V vs. SCE...
  83. Yang X, Luo J, Duan Y, Li S, Liu C. Simultaneous analysis of multiple pesticide residues in minor fruits by ultrahigh-performance liquid chromatography/hybrid quadrupole time-of-fight mass spectrometry. Food Chem. 2018;241:188-198 pubmed publisher
    ..The method consists of a sample extraction step, followed by analysis of the pesticides by UPLC/QTOF-MS...
  84. Sałdyka M, Mielke Z. Photochemistry of Acetohydroxamic Acid in Solid Argon. FTIR and Theoretical Studies. J Phys Chem A. 2017;: pubmed publisher
    ..It is concluded that the first step in formation of the (1), (2) and (3) complexes is the scission of the N-O bond whereas the creation of the complex (..
  85. Ruzza P, Biondi B, Marchiani A, Antolini N, Calderan A. Cell-Penetrating Peptides: A Comparative Study on Lipid Affinity and Cargo Delivery Properties. Pharmaceuticals (Basel). 2010;3:1045-1062 pubmed
    ..Indeed, the binding with cell membrane is one of the primary step in the interaction of CPPs with cells, and consequently the studies on model membrane could become important for ..
  86. Gámiz Hernández A, Jussupow A, Johansson M, Kaila V. Terminal Electron-Proton Transfer Dynamics in the Quinone Reduction of Respiratory Complex I. J Am Chem Soc. 2017;139:16282-16288 pubmed publisher
    ..The initial Q reduction step plays a central role in activating the proton pumping machinery...
  87. Korfiatis P, Kline T, LaChance D, Parney I, Buckner J, Erickson B. Residual Deep Convolutional Neural Network Predicts MGMT Methylation Status. J Digit Imaging. 2017;30:622-628 pubmed publisher
    ..to evaluate their ability in predicting MGMT methylation status without the need for a distinct tumor segmentation step. We found that the ResNet50 (50 layers) architecture was the best performing model, achieving an accuracy of 94...
  88. Wang D, Li Q, Xing Z, Yang X. Copper sulfide nanoplates as nanosensors for fast, sensitive and selective detection of DNA. Talanta. 2018;178:905-909 pubmed publisher
    ..The CuS NPs are successfully synthesized through a mild one-step hydrothermal method...
  89. Oral E, O Brien C, Doshi B, Muratoglu O. High temperature homogenization improves impact toughness of vitamin E-diffused, irradiated UHMWPE. J Orthop Res. 2017;35:1343-1347 pubmed publisher
    ..The dispersion of vitamin E throughout implant preforms has been optimized by a two-step process of doping and homogenization...
  90. Fujita S, Cho S, Yoshida A, Hasebe F, Tomita T, Kuzuyama T, et al. Crystal structure of LysK, an enzyme catalyzing the last step of lysine biosynthesis in Thermus thermophilus, in complex with lysine: Insight into the mechanism for recognition of the amino-group carrier protein, LysW. Biochem Biophys Res Commun. 2017;491:409-415 pubmed publisher
    ..the isopeptide bond between the carrier protein LysW and lysine in order to release lysine, which is the last step of lysine biosynthesis in Thermus thermophilus...
  91. Beevi K, Nair M, Bindu G. A Multi-Classifier System for Automatic Mitosis Detection in Breast Histopathology Images Using Deep Belief Networks. IEEE J Transl Eng Health Med. 2017;5:4300211 pubmed publisher
    ..demonstrates an accurate technique for detecting the mitotic cells in Hematoxyline and Eosin stained images by step by step refinement of segmentation and classification stages...
  92. Xue J, Lin H, Bean A, Tang Y, Tan J, Tuan R, et al. One-Step Fabrication of Bone Morphogenetic Protein-2 Gene-Activated Porous Poly-L-Lactide Scaffold for Bone Induction. Mol Ther Methods Clin Dev. 2017;7:50-59 pubmed publisher
    ..These findings show the potential of the technology toward developing clinical applications of a rapid, cost-effective, and potentially point-of-care approach for the repair of bone defects...