Gene Symbol: PTPMT1
Description: protein tyrosine phosphatase, mitochondrial 1
Alias: DUSP23, MOSP, PLIP, NB4 apoptosis/differentiation related protein, PTEN-like phosphatase, phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, phosphoinositide lipid phosphatase, protein-tyrosine phosphatase mitochondrial 1
- A PTEN-like phosphatase with a novel substrate specificityDavid J Pagliarini
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0721, USA
J Biol Chem 279:38590-6. 2004We show that a novel PTEN-like phosphatase (PLIP) exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate in vitro...
- Chromatography approaches for early screening of the phospholipidosis-inducing potential of pharmaceuticalsZhengjin Jiang
Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research, Jinan University, Guangzhou 510632, China
J Pharm Biomed Anal 61:184-90. 2012..within several different separation systems, was developed for screening phospholipidosis-inducing potential (PLIP) of pharmaceuticals...
- Enhancement of gamma-aminobutyric acid production in Chungkukjang by applying a Bacillus subtilis strain expressing glutamate decarboxylase from Lactobacillus brevisKi Bum Park
Department of Life Science and Technology, Graduate School, Woosuk University, Jeonju 565 701, Korea
Biotechnol Lett 28:1459-63. 2006For a foreign glutamate decarboxylase (GAD) to be expressed in Bacillus host system, a recombinant DNA (pLip/LbGAD) was constructed by ligating an LbGAD gene from Lactobacillus brevis OPK-3 into Escherichia coli-Bacillus shuttle vector, ..
- Firing up mitochondrial activities with PTPMT1Yves Boisclair
Department of Animal Science, Cornell University, 259 Morrison Hall, Ithaca, New York 14853, USA
Mol Cell 19:291-2. 2005Pagliarini et al (2005) recently identified a new mitochondrial specific protein tyrosine phosphatase, PTPMT1. This report comments on its consequences for mitochondrial function and on its potential to act as a therapeutic target in ..
- Pseudohomophone priming in lexical decision is not fragile in a sparse lexical neighborhoodSachiko Kinoshita
ARC Centre of Excellence in Cognition and Its Disorders and Department of Psychology, Macquarie University, Sydney, Australia
J Exp Psychol Learn Mem Cogn 38:764-75. 2012..in English have found a reliable pseudohomophone priming advantage with orthographically similar primes (the klip-plip effect; Frost, Ahissar, Gotesman, & Tayeb, 2003; see Rastle & Brysbaert, 2006, for a review)...
- A Dictyostelium secreted factor requires a PTEN-like phosphatase to slow proliferation and induce chemorepulsionSarah E Herlihy
Department of Biology, Texas A and M University, College Station, TX, USA
PLoS ONE 8:e59365. 2013..Combined, these results suggest that CnrN functions in a signal transduction pathway downstream of AprA and CfaD mediating some, but not all, of the effects of AprA and CfaD...
- Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiationWen Mei Yu
Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
Cell Stem Cell 12:62-74. 2013..Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in ..
- Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula balticaPhildrich G Teh
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, USA
J Biol Chem 288:5176-85. 2013..We recently identified the mitochondrial phosphatase, PTPMT1, as the enzyme that converts phosphatidylglycerolphosphate (PGP) to phosphatidylglycerol, a critical step in the ..
- Multiple operations on the same patientFred L Cohen
Private Practice of Neurological Surgery, Gary Roberts and Associates, West Palm Beach, Florida, USA
Surg Neurol Int 3:S238-43. 2012..surgery facility, performed a staggering number of procedures or "multiple operations on the same patient" (MOSP)...
- Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkeyJ A Sloane
Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurochem 84:157-68. 2003..proteins 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and myelin/oligodendrocyte-specific protein (MOSP) increased dramatically in white matter homogenates and myelin with age...
- Neuronal differentiation of stem cells isolated from adult muscleMarina Romero-Ramos
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
J Neurosci Res 69:894-907. 2002..After 4-6 days the cells expressed neuronal (Tuj1+, NF68), astrocytic (GFAP) and oligodendrocytic (MOSP+, MBP+) markers, both by immunocytochemistry and RT-PCR...
- The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformersArvind Anand
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
J Bacteriol 195:2060-71. 2013..Domain Database (CDD) server revealed that Msp contains two conserved domains, major outer sheath protein(N) (MOSP(N)) and MOSP(C), spanning residues 77 to 286 and 332 to 543, respectively, within the N- and C-terminal regions of ..
- Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell deathNatalie M Niemi
Van Andel Research Institute, Department of Systems Biology, Grand Rapids, Michigan, United States of America
PLoS ONE 8:e53803. 2013Protein Tyrosine Phosphatase localized to the Mitochondrion 1 (PTPMT1) is a dual specificity phosphatase exclusively localized to the mitochondria, and has recently been shown to be a critical component in the cardiolipin biosynthetic ..
- Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucomaHongli Yang
Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
Invest Ophthalmol Vis Sci 52:7109-21. 2011..To quantify the lamina cribrosa insertion into the peripapillary sclera and optic nerve pia in normal (N) and early experimental glaucoma (EEG) monkey eyes...
- Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesisJi Zhang
Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
Cell Metab 13:690-700. 2011b>PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown...
- PTPMT1: connecting cardiolipin biosynthesis to mitochondrial functionKarim El-Kouhen
Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Cell Metab 13:615-7. 2011..In this issue, Zhang et al. (2011) highlight a critical role for PTPMT1, a mitochondrial phosphatase, in cardiolipin biogenesis and possibly in cardiolipin deficiency diseases...
- Synaptically-competent neurons derived from canine embryonic stem cells by lineage selection with EGF and NogginJared T Wilcox
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
PLoS ONE 6:e19768. 2011..or PDGFαα) produced phenotypes equivalent to primary canine neural cells including 3CB2+ radial progenitors, MOSP+ glia restricted precursors, VIM+/GFAP+ astrocytes, and TUBB3+/MAP2+/NFH+/SYN+ neurons...
- Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesisJunyu Xiao
Department of Pharmacology, University of California, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 108:11860-5. 2011b>PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion...
- A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cellsJinhua Shen
Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Mol Cell Biol 31:4902-16. 2011..Global disruption of Ptpmt1, a mitochondrial Pten-like phosphatidylinositol phosphate (PIP) phosphatase, resulted in developmental arrest and ..
- Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitorsHwangseo Park
Department of Bioscience and Biotechnology, Sejong University, 98 Kunja dong, Kwangjin ku, Seoul 143 747, Republic of Korea
Bioorg Med Chem Lett 22:1271-5. 2012Dual-specificity protein tyrosine phosphatase localized to mitochondrion 1 (PTPMT1) has recently proved to be a promising therapeutic target for the treatment of type II diabetes...
- Conformational transformation and selection of synthetic prion strainsSina Ghaemmaghami
Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA 94143, USA
J Mol Biol 413:527-42. 2011..the mechanism of prion strain transformation, we studied the physicochemical evolution of a mouse synthetic prion (MoSP) strain, MoSP1, after repeated passage in mice and cultured cells...
- A PTEN-related 5-phosphatidylinositol phosphatase localized in the GolgiSylvain Merlot
Section of Cell and Developmental Biology, Division of Biological Sciences, Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
J Biol Chem 278:39866-73. 2003..core motif, we have identified a new protein in the Dictyostelium genome called phospholipid-inositol phosphatase (PLIP), which defines a new subfamily of phosphoinositide phosphatases clearly distinct from PTEN or other closely ..
- Myelin oligodendrocyte-specific protein is expressed in Müller cells of myelinated vertebrate retinasAdela Quesada
Departamento de Anatomía e Instituto de Biología del Desarrollo, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
J Neurosci Res 89:674-88. 2011..By immunohistochemistry, with a monoclonal antibody against myelin oligodendrocyte-specific protein (MOSP), we show that MOSP is intensely expressed in the MC and the optic-fiber layer (OFL) in myelinated but not in ..
- Parameterized logarithmic framework for image enhancementKaren Panetta
Department of Electrical and Computer Engineering, Tufts University, Medford, MA 02155, USA
IEEE Trans Syst Man Cybern B Cybern 41:460-73. 2011..In this paper, we introduce a parameterized LIP (PLIP) model that spans both the linear arithmetic and LIP operations and all scenarios in between within a single ..
- Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activationFang Yu Lin
Graduate Institute of Biochemical Sciences, National Taiwan University, Nankang, Taipei 115, Taiwan
Nucleic Acids Res 39:848-61. 2011..Here we show that the interaction of GCM1 and dual-specificity phosphatase 23 (DUSP23) is enhanced by PKA-dependent phosphorylation of GCM1 on Ser269 and Ser275...
- GFAP-positive and myelin marker-positive glia in normal and pathologic environmentsC A Dyer
Department of Pediatrics and Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Neurosci Res 60:412-26. 2000..protein (MBP) gene promoter, GFAP-positive/beta-galactosidase-positive and myelin/oligodendrocyte-specific protein (MOSP)-positive/beta-galactosidase-positive cells were detected in subcortical white matter and in perivascular locations ..
- PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin productionA M Sheridan
Medical Services, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Mol Cell Biol 21:4470-81. 2001..We have identified a nuclear protein, cPLA(2)-interacting protein (PLIP), a splice variant of human Tip60, which interacts with the amino terminal region of cPLA(2)...
- Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humansYannick Doyon
Laval University Cancer Research Center, Hotel Dieu de Quebec, Quebec City, Quebec G1R 2J6, Canada
Mol Cell Biol 24:1884-96. 2004..We demonstrate here that NuA4 complexes are indeed present in human cells. Tip60 and its splice variant Tip60b/PLIP were purified as stable HAT complexes associated with identical polypeptides, with 11 of the 12 proteins being ..
- Peripapillary glial cells in the chick retina: A special glial cell type expressing astrocyte, radial glia, neuron, and oligodendrocyte markers throughout developmentAdela Quesada
Departamento de Ciencias Morfológicas e Instituto de Biología del Desarrollo, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
Glia 46:346-55. 2004..They also express an antigen specific to myelin and oligodendrocytes, MOSP, and a glial antigen, 3CB2, expressed by radial glia and astrocytes throughout the CNS...
- Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brainQihan Wu
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
Int J Biochem Cell Biol 36:1542-53. 2004..In this study, a novel human dual-specificity protein phosphatases gene named dual-specificity phosphatase 23 (DUSP23) was isolated by large-scale sequencing analysis of a human fetal brain cDNA library...
- The protective role of squalene in alcohol damage in the chick embryo retinaYolanda Aguilera
Instituto de Biologia del Desarrollo, Facultad de Medicina, Universidad de Sevilla, Avda Sanchez Pizjuan s n, 41009 Seville, Spain
Exp Eye Res 80:535-43. 2005..At E19 the recuperation of the expression of myelin oligodendrocyte specific protein (MOSP) in alcohol+squalene-treated embryos was recorded...
- cPLA2-interacting protein, PLIP, causes apoptosis and decreases G1 phase in mesangial cellsKatarina Muckova
Renal Div, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Physiol Renal Physiol 290:F70-9. 2006..Kidney Int 52: 294-308, 199). cPLA2-interacting protein (PLIP), the Tip60 splice variant, interacts with cPLA2 and enhances the susceptibility of renal mesangial cells to serum ..
- Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cellsDavid J Pagliarini
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
Mol Cell 19:197-207. 2005..We have discovered that a member of the dual-specific protein tyrosine phosphatase (DS-PTP) family, PTPMT1 (PTP localized to the Mitochondrion 1) resides nearly exclusively in mitochondria...
- Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potentialKaori Tomizawa
Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories Pfizer Inc, Japan
J Toxicol Sci 31:315-24. 2006..We employed a test set of 33 compounds including 11 in-house compounds. The phospholipidosis-inducing potential (PLIP) of the test set compounds was determined by the fluorescence-labeled lipid accumulation assay using isolated rat ..
- Discovery of three novel lipase ( lipA1 , lipA2 , and lipA3) and lipase-specific chaperone ( lipB) genes present in Acinetobacter sp. DYL129Sun Hee Kim
Department of Biotechnology, Faculty of Natural Resources and Life Science, Dong A University, Busan, 604 714, South Korea
Appl Microbiol Biotechnol 77:1041-51. 2008..A genomic library was constructed by using DYL129 fragment digested with HindIII and a recombinant plasmid, pLip-1, was selected for further analysis by colony polymerase chain reaction (PCR). Sequencing of a 3...
- Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complexRakhi Agarwal
Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
J Biol Chem 283:8946-53. 2008..Dual specificity protein phosphatase 23 (DUSP23) or VHZ mediates dephosphorylation of phospho-tyrosyl (pTyr) and phospho-seryl/threonyl (pSer/pThr) residues in ..
- Neural progenitors, neurons and oligodendrocytes from human umbilical cord blood cells in a serum-free, feeder-free cell cultureShawn J Chua
Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ont, Canada M5T 3H7
Biochem Biophys Res Commun 379:217-21. 2009..Early stage oligodendrocyte markers CNPase, GalC, Olig2 and the late-stage marker MOSP are observed, as is the Schwann cell marker PMP22...
- Application of porcine lipase secreted by pichia pastoris to improve fat digestion and growth performance of postweaning pigletsFang Chueh Liu
Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
J Agric Food Chem 58:3322-9. 2010The aim of the study was to use Pichia pastoris to express a recombinant porcine lipase gene (pLip). The expression-secretion cassette was constructed using the P...
- Pharmacological targeting of the mitochondrial phosphatase PTPMT1Dahlia Doughty-Shenton
Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710 3813, USA
J Pharmacol Exp Ther 333:584-92. 2010..PTP localized to mitochondrion 1 (PTPMT1) is a recently discovered dual-specificity phosphatase that has been implicated in the regulation of insulin ..
- VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancersJing Ping Tang
Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Proteos, Singapore
Mol Cancer 9:128. 2010VHZ is a VH1-like (member Z) dual specific protein phosphatase encoded by DUSP23 gene. Some of the dual specific protein phosphatases (DSPs) play an important role in cell cycle control and have shown to be associated with carcinogenesis...
- Evidence for central nervous system glial cell plasticity in phenylketonuriaC A Dyer
E K Shriver Center, Waltham, MA 02254, USA
J Neuropathol Exp Neurol 55:795-814. 1996..basic protein (MBP), 2',3'-cyclic nucleotide 3'phosphohydrolase, and myelin/oligodendrocyte-specific protein (MOSP). However, Western blot analyses also showed that MBP isoform expression was aberrant...
- Phosphoinositide PhosphatasesJack Dixon; Fiscal Year: 2007..structure, function, and regulation of the MTMR family of PTPs, as well as two novel lipid phosphatases, Jumpy and PLIP. Specific Aim 1 will determine the structural basis of how MTMR2 performs its biological function...
- Novel Protein PhosphatasesJack Dixon; Fiscal Year: 2009..signaling pathways involving reversible phosphorylation, we will first perform a thorough characterization of PLIP in Specific Aim 3...
- Novel Protein PhosphatasesJack Dixon; Fiscal Year: 2007..signaling pathways involving reversible phosphorylation, we will first perform a thorough characterization of PLIP in Specific Aim 3...
- Biochemical Basis of Axonal & Myelin Injury In Head TraumaKevin Wang; Fiscal Year: 2007..proteins that are proteolysed after TBI (myelin basic protein [MBP] and myelin oligodendrocyte specific protein [MOSP])...
- Biochem. Basis of Axonal & Myelin Injury In Head TraumaKevin Wang; Fiscal Year: 2006..proteins that are proteolysed after TBI (myelin basic protein [MBP] and myelin oligodendrocyte specific protein [MOSP])...
- IMMUNE MODULATION BY INTESTINAL CELL DIFFERENTIATIONGary Wu; Fiscal Year: 2004..through cell culture models, 2) To clone the PPARgamma Ligand dependent Inhibitor of IkappaB-alpha Phosphorylation (PLIP) as well as identify its kinase target, and 3) To identify the molecular mechanisms by which these ligands activate ..
- Novel Protein PhosphatasesCAROLYN ANN WORBY; Fiscal Year: 2010..This proposal focuses on the mitochondrial phosphatase, PTPMT1 (formerly PLIP), the first resident mitochondrial phosphatase to be identified and functionally linked to energy ..
- TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATHJoseph Bonventre; Fiscal Year: 2009Cytosolic phospholipase A2 interacts with 3 proteins, including Tip60, a Tip60 splice variant which we have called PLIP, and SIRT2...
- TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATHJOSEPH VINCENT BONVENTRE; Fiscal Year: 2010Cytosolic phospholipase A2 interacts with 3 proteins, including Tip60, a Tip60 splice variant which we have called PLIP, and SIRT2...
- MOLECULAR CHARACTERIZATION OF THE JCPK/BPK LOCUSELIZABETH BRYDA; Fiscal Year: 2003..One of these interacting proteins, PLIP, (for Phospholipase A2-interacting protein), has an amino acid sequence containing a recently described MYST domain...
- Protein Tyrosine Phosphatase and Hematopoietic Cell RegulationCheng Kui Qu; Fiscal Year: 2010..The information gathered will provide a molecular basis for a future rational design of new therapeutics that specifically target SHP-2 for treatment of related leukemias. ..
- Protein Tyrosine Phosphatase and Hematopoietic Cell RegulationCheng Kui Qu; Fiscal Year: 2011..The information gathered will provide a molecular basis for a future rational design of new therapeutics that specifically target SHP-2 for treatment of related leukemias. ..
- Protein Tyrosine Phosphatase and Hematopoietic Cell RegulationCheng Kui Qu; Fiscal Year: 2009..The information gathered will provide a molecular basis for a future rational design of new therapeutics that specifically target SHP-2 for treatment of related leukemias. ..
- Tyrosine Phosphatases and Hematopoietic Cell RegulationCheng Kui Qu; Fiscal Year: 2007..The results of these experiments should yield new insights into the intracellular signaling regulation of hematopoiesis, which may lead to novel therapeutic approaches for certain blood disorders. ..
- TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATHAlice Sheridan; Fiscal Year: 2002..One of these interacting proteins, PLIP, (for Phospholipase A2-interacting protein), has an amino acid sequence containing a recently described MYST domain...
- Tyrosine Phosphatases and Hematopoietic Cell RegulationCheng Kui Qu; Fiscal Year: 2005..The results of these experiments should yield new insights into the intracellular signaling regulation of hematopoiesis, which may lead to novel therapeutic approaches for certain blood disorders. ..
- TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATHAlice Sheridan; Fiscal Year: 2007Cytosolic phospholipase A2 interacts with 3 proteins, including Tip60, a Tip60 splice variant which we have called PLIP, and SIRT2...
- SHP-2 Inhibitors as Potential Therapeutic Agents for JMML and Noonan SyndromeCheng Kui Qu; Fiscal Year: 2007..It is anticipated that this study will identify selective and effective SHP-2 inhibitors that can be used as lead compounds for the development of novel therapeutic agents for SHP-2-associated diseases, such as JMML and Noonan syndrome. ..