Gene Symbol: PTP1B
Description: protein tyrosine phosphatase, non-receptor type 1
Alias: PTP1B, tyrosine-protein phosphatase non-receptor type 1, protein tyrosine phosphatase, placental, protein-tyrosine phosphatase 1B
Species: human
Products:     PTP1B

Top Publications

  1. Liang F, Lee S, Liang J, Lawrence D, Zhang Z. The role of protein-tyrosine phosphatase 1B in integrin signaling. J Biol Chem. 2005;280:24857-63 pubmed
    Protein-tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin and leptin signaling and a novel therapeutic target for the treatment of type 2 diabetes, obesity, and other associated metabolic syndromes...
  2. Bjorge J, Pang A, Fujita D. Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. J Biol Chem. 2000;275:41439-46 pubmed
    ..Immunoblotting and immunodepletion experiments identified the phosphatase as protein-tyrosine phosphatase 1B (PTP1B)...
  3. Li S, Depetris R, Barford D, Chernoff J, Hubbard S. Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure. 2005;13:1643-51 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) is a highly specific negative regulator of insulin receptor signaling in vivo...
  4. Liu F, Hill D, Chernoff J. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). J Biol Chem. 1996;271:31290-5 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) is an abundant intracellular enzyme that is thought to act as a negative regulator of certain signaling pathways...
  5. Salmeen A, Andersen J, Myers M, Tonks N, Barford D. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell. 2000;6:1401-12 pubmed
    The protein tyrosine phosphatase PTP1B is responsible for negatively regulating insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase (IRK) activation segment...
  6. Cheyssac C, Lecoeur C, Dechaume A, Bibi A, Charpentier G, Balkau B, et al. Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population. BMC Med Genet. 2006;7:44 pubmed
    ..b>PTP1B is encoded by the PTPN1 gene located on chromosome 20q13 showing linkage with type 2 diabetes (T2D) in several ..
  7. Myers M, Andersen J, Cheng A, Tremblay M, Horvath C, Parisien J, et al. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem. 2001;276:47771-4 pubmed
    ..this concept to the PTPs and demonstrated that (E/D)-pY-pY-(R/K) is a consensus substrate recognition motif for PTP1B. We have shown that JAK2 and TYK2 are substrates of PTP1B and that the substrate recognition site within theses ..
  8. Frangioni J, Beahm P, Shifrin V, Jost C, Neel B. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell. 1992;68:545-60 pubmed
    ..The C-terminal 35 amino acids of PTP-1B are both necessary and sufficient for targeting to the ER. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation. ..
  9. Traurig M, Hanson R, Kobes S, Bogardus C, Baier L. Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians. Diabetologia. 2007;50:985-9 pubmed
    Single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase 1B gene (PTPN1) have been reported to be associated with type 2 diabetes in white subjects, and insulin sensitivity and fasting glucose levels in Hispanic ..

More Information


  1. Xu H, An H, Hou J, Han C, Wang P, Yu Y, et al. Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages. Mol Immunol. 2008;45:3545-52 pubmed publisher
    ..Protein tyrosine phosphatase-1B (PTP1B) has been shown to be a critical negative regulator of insulin pathway and other cellular signaling, however, ..
  2. Arias Romero L, Saha S, Villamar Cruz O, Yip S, Ethier S, Zhang Z, et al. Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res. 2009;69:4582-8 pubmed publisher
    ..Recently, PTP1B was found to have an unexpected positive role in ErbB2 signaling in a mouse model of breast cancer, but the ..
  3. Fukada T, Tonks N. The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase. J Biol Chem. 2001;276:25512-9 pubmed
    Protein-tyrosine phosphatase 1B (PTP1B) is an important regulator of protein-tyrosine kinase-dependent signaling pathways...
  4. Tonks N. Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction. FEBS J. 2013;280:346-78 pubmed publisher
    ..I have discussed various aspects of the structure, regulation and function of the protein tyrosine phosphatase family, which I hope will illustrate the fundamental importance of these enzymes in the control of signal transduction. ..
  5. Milarski K, Zhu G, Pearl C, McNamara D, Dobrusin E, MacLean D, et al. Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B. J Biol Chem. 1993;268:23634-9 pubmed
    ..A bacterial glutathione S-transferase fusion protein containing rat brain phosphatase PTP1b was constructed in which this conserved cysteine was mutated to serine...
  6. Brautigan D, Pinault F. Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid. Mol Cell Biochem. 1993;127-128:121-9 pubmed
    The major intracellular protein tyrosine phosphatase (PTP1B) is a 50kDa protein, localized to the endoplasmic reticulum...
  7. Dadke S, Chernoff J. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Biochem J. 2002;364:377-83 pubmed
    ..Biol. Chem. 271, 31290-31295; Liu, Sells and Chernoff (1998) Curr. Biol. 8, 173-176]. Here we show that PTP1B mutants that are defective in Src homology 3 domain binding fully retain the ability to inhibit insulin signalling,..
  8. Arias Salgado E, Haj F, Dubois C, Moran B, Kasirer Friede A, Furie B, et al. PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol. 2005;170:837-45 pubmed
    ..Thus, PTP-1B is an essential positive regulator of the initiation of outside-in alphaIIbbeta3 signaling in platelets. ..
  9. Gouni Berthold I, Giannakidou E, Muller Wieland D, Faust M, Kotzka J, Berthold H, et al. The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population. J Intern Med. 2005;257:272-80 pubmed
    ..In conclusion, the present data suggest that in a German Caucasian population the Pro387Leu polymorphism of the PTP-1B gene is not associated with DM-2 but may play a role in other metabolic phenotypes. ..
  10. Spencer Jones N, Wang X, Snieder H, Spector T, Carter N, O Dell S. Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population. Diabetes. 2005;54:3296-304 pubmed
    ..PTPN1 variants appear to contribute to central fat and metabolic syndrome traits, secondary to their effect on insulin sensitivity. ..
  11. Bento J, Palmer N, Mychaleckyj J, Lange L, Langefeld C, Rich S, et al. Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes. Diabetes. 2004;53:3007-12 pubmed
    The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC, which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment...
  12. Zhu S, Bjorge J, Fujita D. PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. Cancer Res. 2007;67:10129-37 pubmed
    ..Fyn COOH-terminal peptide phosphorylated by Csk) was greatly increased in the cancer cells and was attributed to PTP1B in most of the cell lines. Membrane PTP1B protein levels were also greatly increased...
  13. Cortesio C, Chan K, Perrin B, Burton N, Zhang S, Zhang Z, et al. Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J Cell Biol. 2008;180:957-71 pubmed publisher
    ..cells show impaired invadopodia formation that is rescued by expression of a truncated fragment of protein tyrosine phosphatase 1B (PTP1B) corresponding to the calpain proteolytic fragment, which indicates that calpain modulates ..
  14. Wu C, Buszard B, Teng C, Chen W, Warr C, Tiganis T, et al. Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. Biochem J. 2011;439:151-9 pubmed publisher
    PTP1B (protein tyrosine phosphatase 1B) is a negative regulator of IR (insulin receptor) activation and glucose homoeostasis, but the precise molecular mechanisms governing PTP1B substrate selectivity and the regulation of insulin ..
  15. Jung E, Kang Y, Kim C. Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro. Biochem Biophys Res Commun. 1998;246:238-42 pubmed
    ..The CPTP1 showed 92% sequence identity to the corresponding 321 amino acid residues of human PTP1B (HPTP1B)...
  16. Groves M, Yao Z, Roller P, Burke T, Barford D. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry. 1998;37:17773-83 pubmed
    ..The crystal structures of protein tyrosine phosphatase 1B (PTP1B) in complex with small molecule inhibitors based upon two classes of phosphotyrosine mimetics, ..
  17. Bandyopadhyay D, Kusari A, Kenner K, Liu F, Chernoff J, Gustafson T, et al. Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. J Biol Chem. 1997;272:1639-45 pubmed
    ..The interaction requires multiple tyrosine phosphorylation sites within both the receptor and PTPase 1B. ..
  18. LaMontagne K, Flint A, Franza B, Pandergast A, Tonks N. Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo. Mol Cell Biol. 1998;18:2965-75 pubmed
    ..In this study, we have demonstrated that expression of PTP1B is enhanced specifically in various cells expressing p210 bcr-abl, including a cell line derived from a patient ..
  19. Liu F, Chernoff J. Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. Biochem J. 1997;327 ( Pt 1):139-45 pubmed
    ..b>PTP1B also interacts with activated platelet-derived growth factor receptor (PDGFR) but not with colony-stimulating ..
  20. Nievergall E, Janes P, Stegmayer C, Vail M, Haj F, Teng S, et al. PTP1B regulates Eph receptor function and trafficking. J Cell Biol. 2010;191:1189-203 pubmed publisher
    ..We demonstrate here that PTP1B governs signaling and biological activity of EphA3...
  21. Sarmiento M, Puius Y, Vetter S, Keng Y, Wu L, Zhao Y, et al. Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition. Biochemistry. 2000;39:8171-9 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) displays a preference for peptides containing acidic as well as aromatic/aliphatic residues immediately NH(2)-terminal to phosphotyrosine...
  22. Monteleone M, González Wusener A, Burdisso J, Conde C, Caceres A, Arregui C. ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface. PLoS ONE. 2012;7:e38948 pubmed publisher
    b>PTP1B is an endoplasmic reticulum (ER) anchored enzyme whose access to substrates is partly dependent on the ER distribution and dynamics...
  23. Eden E, White I, Tsapara A, Futter C. Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction. Nat Cell Biol. 2010;12:267-72 pubmed publisher
    ..Endocytosis of EGFR is required for interaction with the protein tyrosine phosphatase PTP1B (ref...
  24. Seely B, Staubs P, Reichart D, Berhanu P, Milarski K, Saltiel A, et al. Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes. 1996;45:1379-85 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) is a protein tyrosine phosphatase of unknown function, although increasing evidence supports a role for this phosphatase in insulin action...
  25. Lu X, Malumbres R, Shields B, Jiang X, Sarosiek K, Natkunam Y, et al. PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood. 2008;112:4098-108 pubmed publisher
    b>Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed enzyme shown to negatively regulate multiple tyrosine phosphorylation-dependent signaling pathways...
  26. Tiganis T. PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis. FEBS J. 2013;280:445-58 pubmed publisher
    ..The prototypic phosphotyrosine-specific phosphatase PTP1B dephosphorylates the IR and attenuates insulin signaling in muscle and liver...
  27. Meshkani R, Taghikhani M, Al Kateb H, Larijani B, Khatami S, Sidiropoulos G, et al. Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits. Clin Chem. 2007;53:1585-92 pubmed
    b>Protein tyrosine phosphatase 1B (PTPN1) dephosphorylates insulin receptors and attenuates insulin signaling. Polymorphisms in the coding sequence of PTPN1 have been variably associated with type 2 diabetes (T2D)...
  28. Lessard L, Stuible M, Tremblay M. The two faces of PTP1B in cancer. Biochim Biophys Acta. 2010;1804:613-9 pubmed publisher
    b>PTP1B is a classical non-transmembrane protein tyrosine phosphatase that plays a key role in metabolic signaling and is a promising drug target for type 2 diabetes and obesity...
  29. Anderie I, Schulz I, Schmid A. Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets. Cell Signal. 2007;19:582-92 pubmed
    The ubiquitously expressed protein tyrosine phosphatase PTP1B is involved in the regulation of numerous cellular signaling pathways. PTP1B is anchored to the ER membrane while many of its substrates are localized to the plasma membrane...
  30. Krishnan N, Fu C, Pappin D, Tonks N. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal. 2011;4:ra86 pubmed publisher
    ..Here, we report that PTP1B was reversibly inactivated by H(2)S, in vitro and in cells, through sulfhydration of the active-site cysteine ..
  31. Stuible M, Dubé N, Tremblay M. PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446. J Biol Chem. 2008;283:15740-6 pubmed publisher
    The emergence of protein-tyrosine phosphatase 1B (PTP1B) as a potential drug target for treatment of diabetes, obesity, and cancer underlies the importance of understanding its full range of cellular functions...
  32. Chernoff J, Schievella A, Jost C, Erikson R, Neel B. Cloning of a cDNA for a major human protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1990;87:2735-9 pubmed
    ..3-kb insert produces a protein of Mr 56,000, in general agreement with the predicted size. The phosphatase gene appears to be present as a single copy in human genomic DNA and is transcribed into a 3.5-kb message in a variety of tissues. ..
  33. Palmer N, Bento J, Mychaleckyj J, Langefeld C, Campbell J, Norris J, et al. Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study. Diabetes. 2004;53:3013-9 pubmed
    ..001) fasting glucose, respectively, in the IRASFS. This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic traits consistent with the proposed in vivo role for the PTP-1B protein. ..
  34. Xu G, Arregui C, Lilien J, Balsamo J. PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site. J Biol Chem. 2002;277:49989-97 pubmed
    The nonreceptor tyrosine phosphatase PTP1B associates with the cytoplasmic domain of N-cadherin and may regulate cadherin function through dephosphorylation of beta-catenin...
  35. Boute N, Boubekeur S, Lacasa D, Issad T. Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells. EMBO Rep. 2003;4:313-9 pubmed
    ..of the interaction of the insulin receptor with a substrate-trapping mutant of protein-tyrosine phosphatase 1B (PTP1B) were monitored in living human embryonic kidney cells using bioluminescence resonance energy transfer (BRET)...
  36. Espanel X, Huguenin Reggiani M, Hooft van Huijsduijnen R. The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities. Protein Sci. 2002;11:2326-34 pubmed
    ..On SPOT membranes, IR peptides with phosphotyrosine 1163 were efficiently bound by PTP1B D181A, and dephosphorylated by PTP-1B...
  37. Carbone C, Zheng H, Bhattacharya S, Lewis J, Reiter A, Henthorn P, et al. Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proc Natl Acad Sci U S A. 2012;109:19226-31 pubmed publisher
    ..An RNAi-based screen identified PTP1B as a specific regulator of IFNAR1 endocytosis stimulated by IFN1, but not by ligand-independent inducers of IFNAR1 ..
  38. Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R, Koromilas A, et al. Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2? signaling in brown adipocytes. PLoS ONE. 2012;7:e34412 pubmed publisher
    Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress...
  39. Flint A, Tiganis T, Barford D, Tonks N. Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. Proc Natl Acad Sci U S A. 1997;94:1680-5 pubmed
    ..From a mutagenesis study of these invariant residues that was guided by our knowledge of the crystal structure of PTP1B, we have discovered a mutation of the invariant catalytic acid (Asp-181 in PTP1B) that converts an extremely ..
  40. Bettaieb A, Liu S, Xi Y, Nagata N, Matsuo K, Matsuo I, et al. Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. J Biol Chem. 2011;286:9225-35 pubmed publisher
    Protein-tyrosine phosphatase 1B (PTP1B) and T cell protein-tyrosine phosphatase (TCPTP) are closely related intracellular phosphatases implicated in the control of glucose homeostasis...
  41. Di Paola R, Frittitta L, Miscio G, Bozzali M, Baratta R, Centra M, et al. A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance. Am J Hum Genet. 2002;70:806-12 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling and, when overexpressed, plays a role in insulin resistance (Ahmad et al. 1997)...
  42. Zabolotny J, Bence Hanulec K, Stricker Krongrad A, Haj F, Wang Y, Minokoshi Y, et al. PTP1B regulates leptin signal transduction in vivo. Dev Cell. 2002;2:489-95 pubmed
    Mice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resistant to obesity. However, the molecular basis for resistance to obesity has been unclear. Here we show that PTP1B regulates leptin signaling...
  43. Wiesmann C, Barr K, Kung J, Zhu J, Erlanson D, Shen W, et al. Allosteric inhibition of protein tyrosine phosphatase 1B. Nat Struct Mol Biol. 2004;11:730-7 pubmed
    ..Although protein tyrosine phosphatase 1B (PTP1B) has emerged as a promising target for the treatment of both syndromes, the discovery of ..
  44. Dadke S, Cotteret S, Yip S, Jaffer Z, Haj F, Ivanov A, et al. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol. 2007;9:80-5 pubmed
    Protein-tyrosine phosphatase 1B (PTP1B) is an ubiquitously expressed enzyme that negatively regulates growth-factor signalling and cell proliferation by binding to and dephosphorylating key receptor tyrosine kinases, such as the insulin ..
  45. Kamerlin S, Rucker R, Boresch S. A targeted molecular dynamics study of WPD loop movement in PTP1B. Biochem Biophys Res Commun. 2006;345:1161-6 pubmed
    Targeted molecular dynamics was used to examine the mechanism of WPD loop closure in PTP1B, which is essential for the activity of the enzyme...
  46. Zabolotny J, Haj F, Kim Y, Kim H, Shulman G, Kim J, et al. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem. 2004;279:24844-51 pubmed
    Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte antigen-related phosphatase (LAR) as negative regulators of insulin signaling...
  47. Goldstein B, Bittner Kowalczyk A, White M, Harbeck M. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem. 2000;275:4283-9 pubmed
    ..The specific activity of four candidate protein-tyrosine phosphatases (protein-tyrosine phosphatase 1B (PTP1B), SH2 domain-containing PTPase-2 (SHP-2), leukocyte common antigen-related (LAR), and leukocyte antigen-related ..
  48. Charbonneau H, Tonks N, Kumar S, Diltz C, Harrylock M, Cool D, et al. Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. Proc Natl Acad Sci U S A. 1989;86:5252-6 pubmed
    ..Two segments rich in positively charged residues (residues 33-47 and 227-238) may provide sites of interaction with inhibitory anionic polymers such as heparin or poly(Glu/Tyr). ..
  49. Jia Z, Barford D, Flint A, Tonks N. Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. Science. 1995;268:1754-8 pubmed
    The crystal structures of a cysteine-215-->serine mutant of protein tyrosine phosphatase 1B complexed with high-affinity peptide substrates corresponding to an autophosphorylation site of the epidermal growth factor receptor were ..
  50. Kipfer Coudreau S, Eberle D, Sahbatou M, Bonhomme A, Guy Grand B, Froguel P, et al. Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects. Diabetologia. 2004;47:1278-1284 pubmed publisher
    ..b>Protein tyrosine phosphatase 1B (PTP 1B) is an important negative regulator of insulin...
  51. Barford D, Flint A, Tonks N. Crystal structure of human protein tyrosine phosphatase 1B. Science. 1994;263:1397-404 pubmed
    ..The crystal structure of a representative member of this family, the 37-kilodalton form (residues 1 to 321) of PTP1B, has been determined at 2.8 A resolution...
  52. Ragab A, Bodin S, Viala C, Chap H, Payrastre B, Ragab Thomas J. The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking. J Biol Chem. 2003;278:40923-32 pubmed
    ..Concomitant to LAT dephosphorylation, the protein tyrosine phosphatase 1B (PTP1B) was activated through a mechanism involving its proteolysis by calpains downstream of ..
  53. Echwald S, Bach H, Vestergaard H, Richelsen B, Kristensen K, Drivsholm T, et al. A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro. Diabetes. 2002;51:1-6 pubmed
    ..7 (CI 1.26-10.93, P = 0.02) genotype relative risk of type 2 diabetes in the examined population of Danish Caucasian subjects and results in impaired in vitro serine phosphorylation of the PTP-1B peptide. ..
  54. Florez J, Agapakis C, Burtt N, Sun M, Almgren P, Rastam L, et al. Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people. Diabetes. 2005;54:1884-91 pubmed
  55. Mertins P, Eberl H, Renkawitz J, Olsen J, Tremblay M, Mann M, et al. Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics. 2008;7:1763-77 pubmed publisher
    ..Even for the most intensely studied, prototypic family member PTP1B many of its physiological functions cannot be explained by its known substrates...
  56. Romsicki Y, Reece M, Gauthier J, Asante Appiah E, Kennedy B. Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells. J Biol Chem. 2004;279:12868-75 pubmed
  57. Dadke S, Kusari A, Kusari J. Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor. Mol Cell Biochem. 2001;221:147-54 pubmed
    ..reported a direct in vivo interaction between the activated insulin receptor and protein-tyrosine phosphatase-1B (PTP1B), which leads to an increase in PTP1B tyrosine phosphorylation...
  58. Puius Y, Zhao Y, Sullivan M, Lawrence D, Almo S, Zhang Z. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc Natl Acad Sci U S A. 1997;94:13420-5 pubmed
    The structure of the catalytically inactive mutant (C215S) of the human protein-tyrosine phosphatase 1B (PTP1B) has been solved to high resolution in two complexes...
  59. Picha K, Patel S, Mandiyan S, Koehn J, Wennogle L. The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding. J Biol Chem. 2007;282:2911-7 pubmed
    b>Protein tyrosine phosphatase 1B (PTP-1B) has been implicated in the regulation of the insulin receptor. Dephosphorylation of the insulin receptor results in decreased insulin signaling and thus decreased glucose uptake...
  60. Haj F, Markova B, Klaman L, Bohmer F, Neel B. Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B. J Biol Chem. 2003;278:739-44 pubmed
    ..Based on in vitro and ex vivo studies, protein tyrosine phosphatase-1B (PTP1B) was implicated in the regulation of several RTKs, yet mice lacking PTP1B show defects mainly in insulin and ..