PTHLH

Summary

Gene Symbol: PTHLH
Description: parathyroid hormone like hormone
Alias: BDE2, HHM, PLP, PTHR, PTHRP, parathyroid hormone-related protein, PTH-rP, PTH-related protein, osteostatin, parathyroid hormone-like hormone preproprotein, parathyroid hormone-like related protein
Species: human
Products:     PTHLH

Top Publications

  1. Mak I, Cowan R, Turcotte R, Singh G, Ghert M. PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis. PLoS ONE. 2011;6:e19975 pubmed publisher
    ..One of the proteins expressed by these cells is parathyroid hormone-related protein (PTHrP)...
  2. Suva L, Winslow G, Wettenhall R, Hammonds R, Moseley J, Diefenbach Jagger H, et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science. 1987;237:893-6 pubmed
    ..This previously unrecognized hormone may be important in normal as well as abnormal calcium metabolism. ..
  3. Lam M, Thomas R, Martin T, Gillespie M, Jans D. Nuclear and nucleolar localization of parathyroid hormone-related protein. Immunol Cell Biol. 2000;78:395-402 pubmed
    Parathyroid hormone-related protein (PTHrP) was first discovered as the factor causing hypercalcaemia produced by solid tumours frequently associated with the head and neck, breast, lung and kidney...
  4. Richard V, Nadella M, Green P, Lairmore M, Feuer G, Foley J, et al. Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma. Leukemia. 2005;19:1175-83 pubmed
    Parathyroid hormone-related protein (PTHrP) plays a primary role in the development of humoral hypercalcemia of malignancy seen in the majority of adult T-cell leukemia/lymphoma (ATLL) patients with human T-cell lymphotropic virus type-1 ..
  5. Gagiannis S, Müller M, Uhlemann S, Koch A, Melino G, Krammer P, et al. Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria. Int J Cancer. 2009;125:1551-7 pubmed publisher
    ..has a central role in the regulation of serum calcium and phosphate, whereas parathyroid hormone-related peptide (PTHrP) has important developmental roles...
  6. Ardura J, Rayego Mateos S, Rámila D, Ruiz Ortega M, Esbrit P. Parathyroid hormone-related protein promotes epithelial-mesenchymal transition. J Am Soc Nephrol. 2010;21:237-48 pubmed publisher
    ..TGF-beta1 and EGF stimulate EMT. Recent studies suggested that parathyroid hormone-related protein (PTHrP) promotes fibrogenesis in the damaged kidney, apparently dependent on its interaction with vascular endothelial ..
  7. Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, et al. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells. Am J Pathol. 2010;176:968-80 pubmed publisher
    We investigated the roles of interleukin-6 (IL-6) and parathyroid hormone-related peptide (PTHrP) in oral squamous cell carcinoma (OSCC)-induced osteoclast formation...
  8. Hastings R, Burton D, Nefzi A, Montgrain P, Quintana R, Deftos L. Combinatorial library discovery of small molecule inhibitors of lung cancer proliferation and parathyroid hormone-related protein expression. Cancer Biol Ther. 2010;10:1067-75 pubmed publisher
    b>PTHrP (parathyroid hormone-related protein) is abnormally expressed in a substantial majority of lung cancers, especially non-small cell lung cancers, and plays a key role in tumor progression...
  9. Kir S, White J, Kleiner S, Kazak L, Cohen P, Baracos V, et al. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 2014;513:100-4 pubmed publisher
    ..a Lewis lung carcinoma model of cancer cachexia, we show that tumour-derived parathyroid-hormone-related protein (PTHrP) has an important role in wasting, through driving the expression of genes involved in thermogenesis in adipose ..

More Information

Publications110 found, 100 shown here

  1. Mangin M, Webb A, Dreyer B, Posillico J, Ikeda K, Weir E, et al. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci U S A. 1988;85:597-601 pubmed
    ..Southern blot analysis of genomic DNA from humans and rodents revealed a simple pattern compatible with a single-copy gene. The gene has been mapped to chromosome 12. ..
  2. Moseley J, Kubota M, Diefenbach Jagger H, Wettenhall R, Kemp B, Suva L, et al. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci U S A. 1987;84:5048-52 pubmed
    ..The purified PTH-related protein had a specific biological activity approximately equal to 6 times greater than that of bovine PTH(1-34). The PTH-related protein may have a role in the syndrome of humoral hypercalcemia of malignancy. ..
  3. Thiede M, Strewler G, Nissenson R, Rosenblatt M, Rodan G. Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. Proc Natl Acad Sci U S A. 1988;85:4605-9 pubmed
    ..In addition, the 3' untranslated sequence of the cDNA described here has significant similarity to the c-myc protooncogene. ..
  4. Cingolani G, Bednenko J, Gillespie M, Gerace L. Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. Mol Cell. 2002;10:1345-53 pubmed
    ..Other proteins, including parathyroid hormone-related protein (PTHrP), are imported into the nucleus by direct interaction with importin beta...
  5. Shen X, Qian L, Falzon M. PTH-related protein enhances MCF-7 breast cancer cell adhesion, migration, and invasion via an intracrine pathway. Exp Cell Res. 2004;294:420-33 pubmed
    Breast cancer is the most common carcinoma that metastasizes to the bone. Parathyroid hormone-related protein (PTHrP), a known stimulator of osteoclastic bone resorption, is a major mediator of the osteolytic process in breast cancer...
  6. Deftos L, Barken I, Burton D, Hoffman R, Geller J. Direct evidence that PTHrP expression promotes prostate cancer progression in bone. Biochem Biophys Res Commun. 2005;327:468-72 pubmed
    Parathyroid hormone-related protein (PTHrP) is an oncoprotein that is expressed in many malignancies as well as normal tissues. At essentially every site of expression, PTHrP regulates cell growth and proliferation...
  7. Lu Y, Xiao G, Galson D, Nishio Y, Mizokami A, Keller E, et al. PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro. Int J Cancer. 2007;121:724-33 pubmed
    ..Parathyroid hormone-related protein (PTHrP), produced by bone cells and PCa, binds to receptors on osteoblasts and stimulates bone formation and resorption...
  8. Tenne M, McGuigan F, Jansson L, Gerdhem P, Obrant K, Luthman H, et al. Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes. Bone. 2008;42:719-27 pubmed publisher
    Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth...
  9. Liao J, Li X, Koh A, Berry J, Thudi N, Rosol T, et al. Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions. Int J Cancer. 2008;123:2267-78 pubmed publisher
    Expression of parathyroid hormone-related protein (PTHrP) correlates with prostate cancer skeletal progression; however, the impact of prostate cancer-derived PTHrP on the microenvironment and osteoblastic lesions in skeletal metastasis ..
  10. Danilin S, Sourbier C, Thomas L, Rothhut S, Lindner V, Helwig J, et al. von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR. Carcinogenesis. 2009;30:387-96 pubmed publisher
    We have shown that parathyroid hormone-related protein (PTHrP) is a survival factor for human renal cell carcinoma (RCC) and that its expression is negatively regulated by the von Hippel-Lindau (VHL) tumor suppressor gene at the level of ..
  11. Mak I, Turcotte R, Ghert M. Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells. Bone. 2013;55:198-207 pubmed publisher
    Parathyroid-hormone-related protein (PTHrP) has been shown to be an important factor in osteolysis in the setting of metastatic carcinoma to the bone. However, PTHrP may also be central in the setting of primary bone tumors...
  12. Downs T, Burton D, Araiza F, Hastings R, Deftos L. PTHrP stimulates prostate cancer cell growth and upregulates aldo-keto reductase 1C3. Cancer Lett. 2011;306:52-9 pubmed publisher
    The aim of the study was to demonstrate the role of parathyroid hormone related protein (PTHrP) in stimulating aldo-keto reductase (AKR) 1C3 expression in prostate cancer (CaP) cells...
  13. Li J, Karaplis A, Huang D, Siegel P, Camirand A, Yang X, et al. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. J Clin Invest. 2011;121:4655-69 pubmed publisher
    Parathyroid hormone-related protein (PTHrP) is a secreted factor expressed in almost all normal fetal and adult tissues. It is involved in a wide range of developmental and physiological processes, including serum calcium regulation...
  14. Gardella T, Vilardaga J. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev. 2015;67:310-37 pubmed publisher
    ..the levels of calcium and inorganic phosphate in the blood by acting on bone and kidney, and PTH-related protein (PTHrP), a paracrine-factor that regulates cell differentiation and proliferation programs in developing bone and other ..
  15. Yorita K, Tsuji K, Takano Y, Kuroda N, Sakamoto K, Arii K, et al. Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report. BMC Cancer. 2018;18:300 pubmed publisher
    ..Hypercalcemia and high serum levels of parathyroid hormone-related protein (PTHrP) and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) titers were observed...
  16. Demirkan B. The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment. J Clin Med. 2013;2:264-82 pubmed publisher
    ..Understanding the precise mechanisms of EMT and MET in the pathogenesis of breast cancer bone metastasis can inform the direction of therapeutic intervention and possibly prevention. ..
  17. Mrazek A, Porro L, Bhatia V, Falzon M, Spratt H, Zhou J, et al. Apigenin inhibits pancreatic stellate cell activity in pancreatitis. J Surg Res. 2015;196:8-16 pubmed publisher
    ..Additional preclinical testing of apigenin analogs is warranted to develop a therapeutic agent for patients at risk for CP. ..
  18. Fukayama S, Lanske B, Guo J, Kronenberg H, Bringhurst F. Regulation of HSP70 by PTH: a model of gene regulation not mediated by changes in cAMP levels. Am J Physiol. 1996;271:C121-9 pubmed
    ..PTH) activates both adenylate cyclase and phospholipase C in target cells, and cloned PTH/PTH-related protein (PTHrP) receptor can mediate both responses when expressed in host cells such as LLC-PK1 renal epithelial cells...
  19. Salles J. Bone metabolism during pregnancy. Ann Endocrinol (Paris). 2016;77:163-8 pubmed publisher
    ..Mineral regulation is essentially dependent on parathyroid hormone (PTH) and PTH-related protein (PTHrP). The calcium-sensing receptor (CaSR) regulates PTH and PTHrP production...
  20. Maycas M, Ardura J, de Castro L, Bravo B, Gortázar A, Esbrit P. Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival. J Bone Miner Res. 2015;30:1231-44 pubmed publisher
    ..for a short pulse (10 min), with or without PTH1R antagonists or after transfection with specific PTHrP or PTH1R siRNA...
  21. Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, et al. TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Exp Cell Res. 2016;344:67-75 pubmed publisher
    ..in both S and G2/M phase cell distribution accompanied with induction of parathyroid hormone-related protein (PTHrP)...
  22. Li H, Zheng H, Sun Y, Yu Q, Li L. Signal transducer and activator of transcription 5a inhibited by pimozide may regulate survival of goat mammary gland epithelial cells by regulating parathyroid hormone-related protein. Gene. 2014;551:279-89 pubmed publisher
    ..In addition, parathyroid hormone-related protein (PTHrP) is a key regulator in cellular calcium transport, mammary gland development and breast tumor biology...
  23. Nasrabadi D, Rezaeiani S, Eslaminejad M, Shabani A. Improved Protocol for Chondrogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells -Effect of PTHrP and FGF-2 on TGFβ1/BMP2-Induced Chondrocytes Hypertrophy. Stem Cell Rev. 2018;14:755-766 pubmed publisher
    ..growth factors: transforming growth factor beta 1 (TGF-β1), bone morphogenetic protein 2 (BMP2), parathyroid hormone related protein (PTHrP), and fibroblast growth factor 2 (FGF2) according to a defined program...
  24. Kovacs C. Calcium, phosphorus, and bone metabolism in the fetus and newborn. Early Hum Dev. 2015;91:623-8 pubmed publisher
    ..development and serum mineral regulation are dependent upon parathyroid hormone (PTH) and PTH-related protein (PTHrP), but not calcitriol, fibroblast growth factor-23, calcitonin, or the sex steroids...
  25. Sanz Salvador L, García Pérez M, Tarín J, Cano A. Bone metabolic changes during pregnancy: a period of vulnerability to osteoporosis and fracture. Eur J Endocrinol. 2015;172:R53-65 pubmed publisher
    ..Fetal parathyroid hormone (PTH) and PTH-related peptide (PTHrp) play an indirect role through support of a calcium gradient that creates hypercalcemia in the fetus...
  26. Molina López J, Florea D, Quintero Osso B, de la Cruz A, Rodríguez Elvira M, Del Pozo E. Pyridoxal-5'-phosphate deficiency is associated with hyperhomocysteinemia regardless of antioxidant, thiamine, riboflavin, cobalamine, and folate status in critically ill patients. Clin Nutr. 2016;35:706-12 pubmed publisher
    ..05) being associated with PLP deficiency. PLP deficiency was also correlated with hyperhomocysteinemia at two times measured (r. -0...
  27. Zeng C, Guo X, Long J, Kuchenbaecker K, Droit A, Michailidou K, et al. Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res. 2016;18:64 pubmed publisher
    ..Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers...
  28. Yang Y, Ding S, Wang Y, Li C, Shen Y, Meeley R, et al. Small kernel2 Encodes a Glutaminase in Vitamin B6 Biosynthesis Essential for Maize Seed Development. Plant Physiol. 2017;174:1127-1138 pubmed publisher
    ..The B6 vitamer pyridoxal 5'-phosphate (PLP) is drastically reduced in both the smk2 embryo and the endosperm...
  29. DeRatt B, Ralat M, Lysne V, Tayyari F, Dhar I, Edison A, et al. Metabolomic Evaluation of the Consequences of Plasma Cystathionine Elevation in Adults with Stable Angina Pectoris. J Nutr. 2017;147:1658-1668 pubmed publisher
    ..Most endogenously produced H2S is formed by pyridoxal phosphate (PLP)-dependent enzymes by noncanonical reactions of the transsulfuration pathway that yield H2S concurrently ..
  30. El Sayed A, Ruff L, Ghany S, Ali G, ESENER S. Molecular and Spectroscopic Characterization of Aspergillus flavipes and Pseudomonas putida L-Methionine ?-Lyase in Vitro. Appl Biochem Biotechnol. 2017;181:1513-1532 pubmed publisher
    ..of AfMGL and PpMGL via stability of their internal aldimine linkage, tautomerism of pyridoxal 5'-phosphate (PLP) and structural stability responsive to physicochemical factors...
  31. Dexheimer V, Gabler J, Bomans K, Sims T, Omlor G, Richter W. Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation. Sci Rep. 2016;6:36655 pubmed publisher
    ..and its prochondrogenic rather than prohypertrophic role may explain why inhibition of canonical BMP-signalling could not uncouple cartilage matrix production from hypertrophy as this was achieved with pulsed PTHrP-application.
  32. Refolo V, Bez F, Polissidis A, Kuzdas Wood D, Sturm E, Kamaratou M, et al. Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies. Acta Neuropathol Commun. 2018;6:2 pubmed publisher
    ..We investigated selective vulnerability and disease progression in the transgenic PLP-?-syn mouse model of MSA characterized by targeted oligodendroglial ?-synuclein overexpression aiming to provide a ..
  33. Campos R, Zhang L, Drucker D. Differential expression of RNA transcripts encoding unique carboxy-terminal sequences of human parathyroid hormone-related peptide. Mol Endocrinol. 1994;8:1656-66 pubmed
    ..b>PTHrP mRNA transcripts encoding PTHrP-(1-139), -(1-173), or -(1-141) were identified in the majority of tissues analyzed...
  34. Mayengbam S, Raposo S, Aliani M, House J. A Vitamin B-6 Antagonist from Flaxseed Perturbs Amino Acid Metabolism in Moderately Vitamin B-6-Deficient Male Rats. J Nutr. 2016;146:14-20 pubmed publisher
    Pyridoxal 5'-phosphate (PLP) plays a crucial role as a cofactor in amino acid metabolism...
  35. Nematollahi A, Sun G, Harrop S, Hanrahan J, Church W. Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution. Int J Mol Sci. 2016;17:446 pubmed publisher
    Kynurenine aminotransferase II (KAT-II) is a 47 kDa pyridoxal phosphate (PLP)-dependent enzyme, active as a homodimer, which catalyses the transamination of the amino acids kynurenine (KYN) and 3-hydroxykynurenine (3-HK) in the ..
  36. Knight A, Nobili A, van den Bergh T, Genz M, Joosten H, Albrecht D, et al. Bioinformatic analysis of fold-type III PLP-dependent enzymes discovers multimeric racemases. Appl Microbiol Biotechnol. 2017;101:1499-1507 pubmed publisher
    Pyridoxal-5'-phosphate (PLP)-dependent enzymes are ubiquitous in nature and catalyze a variety of important metabolic reactions. The fold-type III PLP-dependent enzyme family is primarily comprised of decarboxylases and alanine racemases...
  37. Huang J, Butler L, Midttun Ø, Koh W, Ueland P, Wang R, et al. Serum B6 vitamers (pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations. Cancer Causes Control. 2016;27:1447-1456 pubmed
    ..To determine whether levels of serum B6 vitamers, including pyridoxal 5'-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (PA), and the PA/(PLP + PL) ratio (PAr), were associated with risk of ..
  38. Kamalakar A, Washam C, Akel N, Allen B, Williams D, Swain F, et al. PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan. J Bone Miner Res. 2017;32:1421-1431 pubmed publisher
    ..We recently identified a unique peptide fragment of parathyroid hormone-related protein (PTHrP), PTHrP(12-48), as a validated serum biomarker in breast cancer patients that correlates with and predicts the ..
  39. Shyh Chang N. Metabolic Changes During Cancer Cachexia Pathogenesis. Adv Exp Med Biol. 2017;1026:233-249 pubmed publisher
    ..although a large number of pro-cachexia circulating factors have been found, such as TNFa, IL-6, myostatin, and PTHrp, none have been shown to be a dominant factor that can be targeted singly to treat cancer cachexia in humans...
  40. Nadella M, Shu S, Dirksen W, Thudi N, Nadella K, Fernandez S, et al. Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation. Retrovirology. 2008;5:46 pubmed publisher
    ..Parathyroid hormone-related protein (PTHrP) plays an important role in the pathogenesis of humoral hypercalcemia of malignancy (HHM) that occurs in the ..
  41. Wit J, Oostdijk W, Losekoot M, van Duyvenvoorde H, Ruivenkamp C, Kant S. MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature. Eur J Endocrinol. 2016;174:R145-73 pubmed publisher
    ..Disorders of signalling of various paracrine factors (FGFs, BMPs, WNTs, PTHrP/IHH, and CNP/NPR2) or genetic defects affecting cartilage extracellular matrix usually cause disproportionate ..
  42. Heppolette C, Chen J, Carr S, Palmer D, Ozanne S. The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget. 2016;7:6398-409 pubmed publisher
    ..Offspring of dams fed a postnatal low-protein (PLP) diet during lactation had a significant increase in thymic cellularity and T cell numbers across their lifespan ..
  43. Mathis D, Abela L, Albersen M, Bürer C, Crowther L, Beese K, et al. The value of plasma vitamin B6 profiles in early onset epileptic encephalopathies. J Inherit Metab Dis. 2016;39:733-741 pubmed publisher
    ..We evaluated the vitamin B6 vitamers pyridoxal 5'-phosphate (PLP), pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN) and the catabolite pyridoxic acid (PA) in the so far largest ..
  44. Tremiño L, Forcada Nadal A, Contreras A, Rubio V. Studies on cyanobacterial protein PipY shed light on structure, potential functions, and vitamin B6 -dependent epilepsy. FEBS Lett. 2017;591:3431-3442 pubmed publisher
    ..This 221-residue protein is monomeric and hosts pyridoxal phosphate (PLP), binding it with limited affinity and losing it upon incubation with D-cycloserine...
  45. Mahoney B, Zhang M, Zintsmaster J, Peng J. Extended Impact of Pin1 Catalytic Loop Phosphorylation Revealed by S71E Phosphomimetic. J Mol Biol. 2018;430:710-721 pubmed publisher
    ..Our results suggest that S71 is a hub residue within an electrostatic network primed for phosphorylation, and may illustrate a common mechanism of phosphorylation-mediated allostery. ..
  46. Ma M, Lohman J, Liu T, Shen B. C-S bond cleavage by a polyketide synthase domain. Proc Natl Acad Sci U S A. 2015;112:10359-64 pubmed publisher
    ..Here we report that: (i) the bioinformatics analysis reveals a pyridoxal phosphate (PLP)-dependent domain, we termed cysteine lyase (SH) domain (LnmJ-SH), within PKS module-8 of LnmJ; (ii) the LnmJ-SH ..
  47. Zhang Y, Dong Q, Li S, Ren W, Shi B, Bai Y, et al. Clinical and Ultrasonographic Features of Secondary Intussusception in Children. Eur Radiol. 2016;26:4329-4338 pubmed
    ..05). Ultrasound was able to demonstrate the pathological lead point (PLP) shadows in all of the 37 SI cases, either in the cervical part or intussusceptum of the intussusception...
  48. Zhao L, Huang L, Zhang X. Systemic lupus erythematosus-related hypercalcemia with ectopic calcinosis. Rheumatol Int. 2016;36:1023-6 pubmed publisher
    ..She had abnormally high serum parathyroid hormone-related protein (PTHrP) which fell to normal after treatment...
  49. Al Menhali A, Keeley T, Demitrack E, Samuelson L. Gastrin induces parathyroid hormone-like hormone expression in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol. 2017;312:G649-G657 pubmed publisher
    ..Our previous gene expression profiling studies of mouse stomach identified parathyroid hormone-like hormone (PTHLH) as a potential gastrin-regulated gastric growth factor...
  50. Esser A, Rauch D, Xiang J, Harding J, Kohart N, Ross M, et al. HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice. Oncotarget. 2017;8:69250-69263 pubmed publisher
    ..Bone-acting factors were present in serum and RANKL, PTHrP and DKK1, key mediators of hypercalcemia and bone loss, were upregulated in Gzmb-HBZ T cells...
  51. Nguyen M, He B, Karaplis A. Nuclear forms of parathyroid hormone-related peptide are translated from non-AUG start sites downstream from the initiator methionine. Endocrinology. 2001;142:694-703 pubmed
    PTH-related peptide (PTHrP), normally a secreted protein, exerts at least part of its biological functions via intracrine actions at the level of the cell nucleus/nucleolus...
  52. Veeravigrom M, Damrongphol P, Ittiwut R, Ittiwut C, Suphapeetiporn K, Shotelersuk V. Pyridoxal 5ꞌ-phosphate-responsive epilepsy with novel mutations in the PNPO gene: a case report. Genet Mol Res. 2015;14:14130-5 pubmed publisher
    Pyridoxal 5'-phosphate (PLP)-responsive epilepsy is a rare autosomal recessive epileptic disorder caused by deficiency of pyridox(am)-ne 5'-phosphate oxidase (PNPO)...
  53. Whittaker J. Intracellular trafficking of the pyridoxal cofactor. Implications for health and metabolic disease. Arch Biochem Biophys. 2016;592:20-6 pubmed publisher
    ..Compared to the processes involved in cellular uptake and processing of the B6 vitamers, trafficking of the PLP cofactor across intracellular membranes is very poorly understood, even though the availability of PLP within ..
  54. Mikel P, Vasickova P, Kralik P. One-plasmid double-expression His-tag system for rapid production and easy purification of MS2 phage-like particles. Sci Rep. 2017;7:17501 pubmed publisher
    MS2 phage-like particles (MS2 PLP) are artificially constructed pseudo-viral particles derived from bacteriophage MS2...
  55. Wang N, Li P, Liu W, Wang N, Lu Z, Feng J, et al. miR-141-3p suppresses proliferation and promotes apoptosis by targeting GLI2 in osteosarcoma cells. Oncol Rep. 2018;39:747-754 pubmed publisher
    ..The findings of the present study may provide a new target for treating osteosarcoma...
  56. Welsch N, Brown A, Barker T, Lyon L. Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels. Colloids Surf B Biointerfaces. 2018;166:89-97 pubmed publisher
    ..Compared to control clots with an elastic modulus of 460+/-260?Pa, PEG-PLP-reinforced fibrin clots exhibit higher degrees of stiffness as demonstrated by the significantly increased average ..
  57. Garcia Martin A, Ardura J, Maycas M, Lozano D, López Herradón A, Portal Núñez S, et al. Functional roles of the nuclear localization signal of parathyroid hormone-related protein (PTHrP) in osteoblastic cells. Mol Endocrinol. 2014;28:925-34 pubmed publisher
    b>PTHrP is an important regulator of bone remodelling, apparently by acting through several sequence domains...
  58. Sharma K, Singh J, Pillai P, Frost E. Involvement of MeCP2 in Regulation of Myelin-Related Gene Expression in Cultured Rat Oligodendrocytes. J Mol Neurosci. 2015;57:176-84 pubmed publisher
    ..small interference RNA (siRNA) has shown increase in myelin genes (myelin basic protein (MBP), proteolipid protein (PLP), myelin oligodendrocyte glycoprotein (MOG), and myelin-associated oligodendrocyte basic protein (MOBP)), ..
  59. GÅ‚owacki R, Stachniuk J, Borowczyk K, Jakubowski H. Quantification of homocysteine and cysteine by derivatization with pyridoxal 5'-phosphate and hydrophilic interaction liquid chromatography. Anal Bioanal Chem. 2016;408:1935-41 pubmed publisher
    A simple and rapid assay using pyridoxal 5'-phosphate (PLP) as a derivatizing reagent was developed for the simultaneous determination of homocysteine (Hcy) and cysteine (Cys) in human plasma...
  60. Thiele S, Mantovani G, Barlier A, Boldrin V, Bordogna P, de Sanctis L, et al. From pseudohypoparathyroidism to inactivating PTH/PTHrP signalling disorder (iPPSD), a novel classification proposed by the EuroPHP network. Eur J Endocrinol. 2016;175:P1-P17 pubmed
    ..network decided to develop a new classification that encompasses all disorders with impairments in PTH and/or PTHrP cAMP-mediated pathway. Extensive review of the literature was performed...
  61. Amorim Franco T, Favrot L, Vergnolle O, Blanchard J. Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem Biol. 2017;12:1235-1244 pubmed publisher
    The branched-chain aminotransferase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme responsible for the final step in the biosynthesis of all three branched-chain amino acids, l-leucine, l-isoleucine, and l-valine, in bacteria...
  62. Lam M, House C, Tiganis T, Mitchelhill K, Sarcevic B, Cures A, et al. Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization. J Biol Chem. 1999;274:18559-66 pubmed
    Parathyroid hormone-related protein (PTHrP) is expressed by a wide variety of cells and is considered to act as a secreted factor; however, evidence is accumulating for it to act in an intracrine manner...
  63. Martinez M, Garcia Ocana A, Sanchez M, Medina S, del Campo T, Valin A, et al. C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells. J Bone Miner Res. 1997;12:778-85 pubmed
    Parathyroid hormone-related protein (PTHrP) is synthesized by osteoblasts, although its local role in bone is not completely understood...
  64. Tobias J, Cooper C. PTH/PTHrP activity and the programming of skeletal development in utero. J Bone Miner Res. 2004;19:177-82 pubmed
    ..Although the mechanisms involved are unknown, circumstantial evidence points to an important role of PTH/PTHrP activity...
  65. Hastings R, Araiza F, Burton D, Bedley M, Deftos L. Parathyroid hormone-related protein regulates apoptosis in lung cancer cells through protein kinase A. Am J Physiol Cell Physiol. 2004;287:C1616-22 pubmed
    Parathyroid hormone-related protein (PTHrP)-(1-34) and PTHrP-(140-173) protect lung cancer cells from apoptosis after ultraviolet (UV) irradiation...
  66. Sellers R, Luchin A, Richard V, Brena R, Lima D, Rosol T. Alternative splicing of parathyroid hormone-related protein mRNA: expression and stability. J Mol Endocrinol. 2004;33:227-41 pubmed
    Parathyroid hormone-related protein (PTHrP) is a multifunctional protein that is often dysregulated in cancer...
  67. Allan E, Häusler K, Wei T, Gooi J, Quinn J, Crimeen Irwin B, et al. EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts. J Bone Miner Res. 2008;23:1170-81 pubmed publisher
    With the aim of identifying new pathways and genes regulated by PTH(1-34) and PTH-related protein 1-141 [PTHrP(1-141)] in osteoblasts, this study was carried out using a mouse marrow stromal cell line, Kusa 4b10, that acquires features ..
  68. Pioszak A, Parker N, Gardella T, Xu H. Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem. 2009;284:28382-91 pubmed publisher
    Parathyroid hormone (PTH) and PTH-related protein (PTHrP) are two related peptides that control calcium/phosphate homeostasis and bone development, respectively, through activation of the PTH/PTHrP receptor (PTH1R), a class B G protein-..
  69. Mak I, Turcotte R, Ghert M. Transcriptomic and proteomic analyses in bone tumor cells: Deciphering parathyroid hormone-related protein regulation of the cell cycle and apoptosis. J Bone Miner Res. 2012;27:1976-91 pubmed publisher
    ..laboratory, including functional assays, have shown that neutralization of parathyroid hormone-related protein (PTHrP) in the cell environment inhibits cell proliferation and induces cell death in GCT stromal cells, indicating a ..
  70. Weaver S, LaPorta J, Moore S, Hernandez L. Serotonin and calcium homeostasis during the transition period. Domest Anim Endocrinol. 2016;56 Suppl:S147-54 pubmed publisher
    ..Further research into serotonin's potential as a therapeutic target could contribute significantly as a preventive strategy against hypocalcemia in early lactation dairy cows. ..
  71. Mareddy J, Suresh N, Kumar C, Kapavarapu R, Jayasree A, Pal S. 1,2,3-Triazole-nimesulide hybrid: Their design, synthesis and evaluation as potential anticancer agents. Bioorg Med Chem Lett. 2017;27:518-523 pubmed publisher
    ..They also inhibited PDE4B in vitro (60-70% at 10?M) that was supported by the docking studies (PLP score 87-94) in silico.
  72. Pascual M, Montesinos J, Montagud Romero S, Forteza J, Rodriguez Arias M, Minarro J, et al. TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders. J Neuroinflammation. 2017;14:145 pubmed publisher
    ..markers (CD11b and MHC-II), and with a reduction in some synaptic (synaptotagmin, synapsin IIa) and myelin (MBP, PLP) proteins in the brains of offspring on days 0, 20, and 66 (long-term effects)...
  73. Kikkert S, Mezue M, Henderson Slater D, Johansen Berg H, Tracey I, Makin T. Motor correlates of phantom limb pain. Cortex. 2017;95:29-36 pubmed publisher
    ..While phantom sensations can be innocuous, they are often manifested as painful. Phantom limb pain (PLP) is notorious for being difficult to monitor and treat...
  74. Borchert A, Downs D. Endogenously generated 2-aminoacrylate inhibits motility in Salmonella enterica. Sci Rep. 2017;7:12971 pubmed publisher
    ..In S. enterica, 2AA inactivates a number of pyridoxal 5'-phosephate(PLP)-dependent enzymes, some of which have been linked to the growth phenotypes of a ridA mutant...
  75. Tay D, Cremers S, Bilezikian J. Optimal dosing and delivery of PTH and its analogues for osteoporosis and hypoparathyroidism - translating the pharmacology. Br J Clin Pharmacol. 2017;: pubmed publisher
    ..continuous or intermittent, but also on how the PTH molecule interacts with various states of its receptor (PTH/PTHrP receptor) influencing downstream signaling pathways differentially...
  76. Wu Y, Chen J, Liu Z, Wang F. Identification of pyridoxal phosphate modified proteins using mass spectrometry. Rapid Commun Mass Spectrom. 2017;: pubmed publisher
    Pyridoxal 5'-phosphate (PLP) cooperates with a variety of enzymes in all organisms for many important biological processes...
  77. Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, et al. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol. 1997;136:205-13 pubmed
    Parathyroid hormone-related peptide (PTHrP) appears to play a major role in skeletal development. Targeted disruption of the PTHrP gene in mice causes skeletal dysplasia with accelerated chondrocyte maturation (Amizuka, N., H...
  78. Sirchia R, Luparello C. Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. Biol Chem. 2007;388:457-65 pubmed
    We have previously shown that PTHrP(38-94) amide restrains growth and invasion in vitro, causes striking toxicity and accelerates death of some breast cancer cell lines, the most responsive being MDA-MB231, for which tumorigenesis was ..
  79. Katseli A, Maragos H, Nezos A, Syrigos K, Koutsilieris M. Multiplex PCR-based detection of circulating tumor cells in lung cancer patients using CK19, PTHrP, and LUNX specific primers. Clin Lung Cancer. 2013;14:513-20 pubmed publisher
    ..Samples were analyzed using multiplex PCR, and specific primers for CK19, PTHrP, and LUNX mRNA...
  80. Lezcano V, Gentili C, de Boland A. Role of PTHrP in human intestinal Caco-2 cell response to oxidative stress. Biochim Biophys Acta. 2013;1833:2834-2843 pubmed publisher
    ..apoptosis in human colon adenocarcinoma Caco-2 cells but the effects of its tumoral analog PTH-related peptide (PTHrP) in this cell line are still unknown...
  81. Inoue D. [Role for PTHrP in bone and cartilage metabolism]. Clin Calcium. 2014;24:863-9 pubmed publisher
    PTH-related peptide (PTHrP) is a widely distributed cytokine, which shares the cognate receptor PTHR1 with PTH...
  82. Palavicini J, Wang C, Chen L, Ahmar S, Higuera J, Dupree J, et al. Novel molecular insights into the critical role of sulfatide in myelin maintenance/function. J Neurochem. 2016;139:40-54 pubmed publisher
    ..of the major compact myelin proteins (myelin basic protein, myelin basic protein, and proteolipid protein, PLP) and an equivalent post-developmental loss of myelin lipids, providing the molecular basis behind the thinner ..
  83. Whyte M. Hypophosphatasia: Enzyme Replacement Therapy Brings New Opportunities and New Challenges. J Bone Miner Res. 2017;32:667-675 pubmed publisher
    ..Severely affected infants may seize from insufficient hydrolysis of pyridoxal 5'-phosphate (PLP), the major extracellular vitamin B6 ...
  84. Accorsi A, Benatti S, Ross E, Nasi M, Malagoli D. A prokineticin-like protein responds to immune challenges in the gastropod pest Pomacea canaliculata. Dev Comp Immunol. 2017;72:37-43 pubmed publisher
    ..We have identified a prokineticin-like protein (PlP), that we called Pc-plp and we analyzed by real-time PCR (qPCR) its expression...
  85. Batllori M, Molero Luís M, Ormazabal A, Casado M, Sierra C, Garcia Cazorla A, et al. Analysis of human cerebrospinal fluid monoamines and their cofactors by HPLC. Nat Protoc. 2017;12:2359-2375 pubmed publisher
    The presence of monoamines and their cofactors (the pterins and vitamin B6 (pyridoxal phosphate (PLP))) in human cerebrospinal fluid (CSF) can be used as indicators of the biosynthesis and turnover of dopamine and serotonin in ..
  86. Agaimy A, Strobel D, Strecker T. SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient. Case Rep Pathol. 2017;2017:9403467 pubmed publisher
    ..The serum parathyroid hormone-related protein (PTHrp) was significantly elevated (241?pg/ml; reference value < 57)...
  87. Wang L, Winnewisser J, Federle C, Jessberger G, Nave K, Werner H, et al. Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis. Front Immunol. 2017;8:1511 pubmed publisher
    ..BL/6 mice are largely resistant to EAE induction with proteolipid protein (PLP), probably a reflection of antigen-specific tolerance...
  88. Fenton A, Kemp B, Hammonds R, Mitchelhill K, Moseley J, Martin T, et al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991;129:3424-6 pubmed
    ..We now report that this bone resorption inhibitory activity, which we have called osteostatin, is entirely contained within the highly conserved pentapeptide PTHrP[107-111]...
  89. Ogino K, Ogura K, Kinugasa Y, Furuse Y, Uchida K, Shimoyama M, et al. Parathyroid hormone-related protein is produced in the myocardium and increased in patients with congestive heart failure. J Clin Endocrinol Metab. 2002;87:4722-7 pubmed
    b>PTHrP is produced in a wide variety of different cells, including cardiomyocytes. Its production is augmented by mechanical and neurohumoral stimulation, and PTHrP has positive chronotropic and vasodilatory effects...
  90. Cros M, Cataisson C, Cho Y, Berthois Y, Bernard Poenaru O, Denne M, et al. Constitutive production of parathyroid hormone-related protein (PTHrP) by fibroblasts derived from normal and pathological human breast tissue. Oncol Res. 2002;13:137-46 pubmed
    Parathyroid hormone-related protein (PTHrP) is expressed in the mammary gland and appears to be critical to the morphogenesis of this structure. PTHrP production in the breast is generally attributed to epithelial cells...
  91. Yamanaka Y, Tanaka H, Koike M, Nishimura R, Seino Y. PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation. J Bone Miner Res. 2003;18:1395-403 pubmed
    ..ACH chondrocytes exhibited marked apoptotic with downregulation of PTHrP expression. Rescue of these cells by PTHrP replacement implies a potential therapy for this disorder...
  92. Chen C, Koh A, Datta N, Zhang J, Keller E, Xiao G, et al. Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts. J Biol Chem. 2004;279:29121-9 pubmed
    Parathyroid hormone-related protein (PTHrP) regulates proliferation and differentiation of osteoblastic cells via binding to the parathyroid hormone receptor (PTH-1R)...