Gene Symbol: PTH2R
Description: parathyroid hormone 2 receptor
Alias: PTHR2, parathyroid hormone 2 receptor, PTH2 receptor, parathyroid hormone receptor 2
Species: human
Products:     PTH2R

Top Publications

  1. Liu S, Cheloha R, Watanabe T, Gardella T, Gellman S. Receptor selectivity from minimal backbone modification of a polypeptide agonist. Proc Natl Acad Sci U S A. 2018;115:12383-12388 pubmed publisher
    ..relative to PTH(1-34)-NH2 itself, displayed a wide range of potencies in cell-based assays for PTHR1 or PTHR2 activation...
  2. Pinheiro P, Cardoso J, Power D, Canario A. Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken. BMC Evol Biol. 2012;12:110 pubmed publisher
    ..Two PTH/PTHrP receptors, PTH1R and PTH2R exist in mammals and in teleost fish a further receptor PTH3R has also been identified...
  3. Uno N, Fujimoto T, Komoto S, Kurosawa G, Sawa M, Suzuki T, et al. A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein-protein interactions mediated by G protein-coupled receptors. Cytotechnology. 2018;70:1499-1508 pubmed publisher
    ..Second, a parathyroid hormone receptor 2 (PTHR2)-CEluc or prostaglandin EP4 receptor (hEP4)-CEluc were inserted into ARRB1-MAC4, named ARRB1-..
  4. Dobolyi A, Palkovits M, Usdin T. The TIP39-PTH2 receptor system: unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms. Prog Neurobiol. 2010;90:29-59 pubmed publisher
    ..residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled parathyroid hormone 2 receptor (PTH2R)...
  5. Dimitrov E, Kim Y, Usdin T. Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation. J Neurosci. 2011;31:18166-79 pubmed publisher
    ..Tuberoinfundibular peptide of 39 residues (TIP39) is a ligand for the parathyroid hormone 2 receptor (PTH2R). Both peptide and receptor are abundant in the preoptic hypothalamus...
  6. Gardella T, Vilardaga J. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev. 2015;67:310-37 pubmed publisher
    ..The type-2 parathyroid hormone receptor (PTHR2) binds a peptide ligand, called tuberoinfundibular peptide-39 (TIP39), and while the biologic role of the PTHR2/..
  7. Galloway T, Fletcher T, Thomas O, Lee B, Pilling L, Harries L. PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere. 2015;120:555-62 pubmed publisher
    ..used multivariate linear regression models and found that PFOA or PFOS was inversely correlated with parathyroid hormone 2 receptor (PTH2R) expression (coefficients=-0.43 and -0.32, p=p=0.017 and 0...
  8. Cservenák M, Szabó Ã, Bodnár I, Lékó A, Palkovits M, Nagy G, et al. Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. Psychoneuroendocrinology. 2013;38:3070-84 pubmed publisher
    ..Since TIP39-containing fibers and the receptor for TIP39, the parathyroid hormone 2 receptor (PTH2 receptor) are abundant in the arcuate nucleus and the medial preoptic area, we antagonized TIP39 ..
  9. Sato E, Zhang L, Dorschner R, Adase C, Choudhury B, Gallo R. Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol. 2017;137:1774-1783 pubmed publisher
    ..Small interfering RNA-mediated silencing of parathyroid hormone 2 receptor (PTH2R), the receptor for TIP39, suppressed the expression of extracellular matrix-related genes, ..

More Information


  1. Weaver R, Mobarec J, Wigglesworth M, Reynolds C, Donnelly D. High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochem Pharmacol. 2017;127:71-81 pubmed publisher
    TIP39 ("tuberoinfundibular peptide of 39 residues") acts via the parathyroid hormone 2 receptor, PTH2, a Family B G protein-coupled receptor (GPCR)...
  2. Tsuda M, Yeung H, Kuo J, Usdin T. Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala. J Neurosci. 2015;35:12152-61 pubmed publisher
    ..that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory...
  3. Sasaki S, Ibi T, Kojima T, Sugimoto Y. A genome-wide association study reveals a quantitative trait locus for days open on chromosome 2 in Japanese Black cattle. Anim Genet. 2016;47:102-5 pubmed publisher
    ..These SNPs were located on the telomeric side at a distance of 177 kb from the parathyroid hormone 2 receptor (PTH2R) gene. The association was replicated in a sample of 1778 animals...
  4. Wilgus T. New Mechanisms of ECM Production during Wound Healing: A Role for Parathyroid Hormone 2 Receptor Signaling. J Invest Dermatol. 2017;137:1617-1619 pubmed publisher
    ..Extracellular matrix deposition is required for wound healing. Studies by Sato et al. reveal a role for parathyroid hormone 2 receptor (PTH2R) in extracellular matrix production in wounds...
  5. Mahon M, Shimada M. Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. FEBS Lett. 2005;579:803-7 pubmed
    ..Fluphenazine, a calmodulin antagonist, enhances PTH-mediated accumulation of total inositol phosphates, suggesting that calmodulin regulates signaling via phospholipase C. ..
  6. Mann R, Wigglesworth M, Donnelly D. Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor. Mol Pharmacol. 2008;74:605-13 pubmed publisher
    ..Analysis of this functionally important ligand-receptor contact, within the context of the recent X-ray structure of the peptide-bound PTH-1R N domain, reveals the nature of the selectivity filter and how it is by-passed in PTH-1R. ..
  7. Akesson K, Tenne M, Gerdhem P, Luthman H, McGuigan F. Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine. J Bone Miner Metab. 2015;33:9-15 pubmed publisher
    ..and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women...
  8. Wei S, Wang L, McHugh M, Han Y, Xiong M, Amos C, et al. Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility. Carcinogenesis. 2012;33:1531-7 pubmed publisher
    ..Our findings suggest that immune function regulation-related pathways may be mechanistically involved in asbestos-associated lung cancer risk...
  9. Panda D, Goltzman D, Karaplis A. Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor. Am J Physiol Endocrinol Metab. 2012;303:E1489-501 pubmed publisher
    The human parathyroid hormone type 2 receptor (PTH2R) is activated by PTH and by tuberoinfundibular peptide of 39 residues (TIP39), the latter likely acting as its natural ligand...
  10. Potthoff S, Janus A, Hoch H, Frahnert M, Tossios P, Reber D, et al. PTH-receptors regulate norepinephrine release in human heart and kidney. Regul Pept. 2011;171:35-42 pubmed publisher
    ..The highly increased PTH levels that can be observed in chronic renal failure might be one contributor for the elevated sympathetic nerve activity and the associated cardiovascular mortality in patients with end stage renal disease...
  11. Bagó A, Dimitrov E, Saunders R, Seress L, Palkovits M, Usdin T, et al. Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. Neuroscience. 2009;162:128-47 pubmed publisher
    b>Parathyroid hormone receptor 2 (PTH2R) and its ligand, tuberoinfundibular peptide of 39 residues (TIP39) constitute a neuromodulator system implicated in endocrine and nociceptive regulation...
  12. Tenne M, McGuigan F, Jansson L, Gerdhem P, Obrant K, Luthman H, et al. Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes. Bone. 2008;42:719-27 pubmed publisher
    ..Both PTH and PTHrP act through the same receptor (PTHR1). A second receptor, PTHR2, has been identified although its function is comparatively unknown...
  13. Bisello A, Manen D, Pierroz D, Usdin T, Rizzoli R, Ferrari S. Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. Mol Endocrinol. 2004;18:1486-98 pubmed
    The human PTH receptor type 2 (PTH2R) is activated by PTH and tuberoinfundibular peptide of 39 residues (TIP39), resulting in cAMP and intracellular Ca signaling...
  14. Seeliger S, Hausberg M, Eue I, Usdin T, Rahn K, Kosch M. The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism. Clin Nephrol. 2003;59:429-35 pubmed
    ..Recently, a new G protein-coupled receptor with substantial implications for vascular function--the PTH2 receptor (PTH2-R)--has been identified, however, expression and distribution in humans and a possible regulation has ..
  15. John M, Arai M, Rubin D, Jonsson K, Juppner H. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology. 2002;143:1047-57 pubmed
    ..Because PTH2 receptor expression was previously shown to be highest in brain, pancreas, and testis, our findings are consistent with ..
  16. Hoare S, Clark J, Usdin T. Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity. J Biol Chem. 2000;275:27274-83 pubmed
    ..In this study, we investigated the molecular determinants of both ligand and receptor for the PTH2 receptor selectivity of TIP39 and quantitatively evaluated the role of molecular elements in the binding of TIP39 to ..
  17. Clark J, Bonner T, Kim A, Usdin T. Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors. Mol Endocrinol. 1998;12:193-206 pubmed
    ..Only PTH activates the PTH2 receptor. To examine the structural basis for this selectivity, we analyzed receptor chimeras in which the amino ..
  18. Usdin T, Modi W, Bonner T. Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. Genomics. 1996;37:140-1 pubmed
  19. Usdin T, Gruber C, Bonner T. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. J Biol Chem. 1995;270:15455-8 pubmed
    ..a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) ..
  20. Bagó A, Palkovits M, Usdin T, Seress L, Dobolyi A. Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem. Ideggyogy Sz. 2008;61:123-6 pubmed
    The parathyroid hormone 2 receptor (PTH2R) is a G protein coupled receptor...
  21. Kim J, Won H, Kim Y, Choi J, Yu N, Lee K. Breakpoint mapping by whole genome sequencing identifies PTH2R gene disruption in a patient with midline craniosynostosis and a de novo balanced chromosomal rearrangement. J Med Genet. 2015;52:706-9 pubmed publisher
    ..An intronic break of the PTH2R gene was detected by whole genome sequencing and fluorescence in situ hybridisation analysis confirmed disruption ..
  22. Sato E, Muto J, Zhang L, Adase C, Sanford J, Takahashi T, et al. The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation. J Invest Dermatol. 2016;136:1449-1459 pubmed publisher
    ..In this study, we examined the expression and potential functions of the PTH second receptor (PTH2R) and its ligand, the tuberoinfundibular peptide of 39 residues (TIP39), in the skin...