PTH2

Summary

Gene Symbol: PTH2
Description: parathyroid hormone 2
Alias: TIP39, tuberoinfundibular peptide of 39 residues, tuberoinfundibular 39 residue protein
Species: human
Products:     PTH2

Top Publications

  1. Pinheiro P, Cardoso J, Power D, Canario A. Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken. BMC Evol Biol. 2012;12:110 pubmed publisher
    ..The vertebrate PTH2R receptor and its ligand TIP39 have been lost from bird genomes...
  2. Dimitrov E, Kim Y, Usdin T. Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation. J Neurosci. 2011;31:18166-79 pubmed publisher
    ..b>Tuberoinfundibular peptide of 39 residues (TIP39) is a ligand for the parathyroid hormone 2 receptor (PTH2R)...
  3. Palkovits M, Helfferich F, Dobolyi A, Usdin T. Acoustic stress activates tuberoinfundibular peptide of 39 residues neurons in the rat brain. Brain Struct Funct. 2009;214:15-23 pubmed publisher
    ..noise for 30 min, Fos-like immunoreactivity (Fos-ir) was investigated in neurons that synthesize tuberoinfundibular peptide of 39 residues (TIP39) in the rat brain: in the subparafascicular area of the thalamus, the posterior ..
  4. Gardella T, Vilardaga J. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev. 2015;67:310-37 pubmed publisher
    ..The type-2 parathyroid hormone receptor (PTHR2) binds a peptide ligand, called tuberoinfundibular peptide-39 (TIP39), and while the biologic role of the PTHR2/TIP39 system is not as defined as that of the PTHR1, it likely plays a ..
  5. Forrest S, Pringle P, Sparkes H, Wass D. Reversible CO exchange at platinum(0). An example of similar complex properties produced by ligands with very different stereoelectronic characteristics. Dalton Trans. 2014;43:16335-44 pubmed publisher
    ..Ethene reacts smoothly with 2a to give (4a) and H2 with 2a generates some [PtH2(La)]. Protonation of 2a gives [Pt(La)(H)(CO)][B(C6F5)4] (5a) whose crystal structure has been determined...
  6. Coutellier L, Usdin T. Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling. Behav Brain Res. 2011;222:265-9 pubmed publisher
    ..We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences...
  7. Palkovits M, Usdin T, Makara G, Dobolyi A. Tuberoinfundibular peptide of 39 residues- immunoreactive fibers in the zona incerta and the supraoptic decussations terminate in the neuroendocrine hypothalamus. Neurochem Res. 2010;35:2078-85 pubmed publisher
    b>Tuberoinfundibular peptide of 39 residues (TIP39) is expressed by neurons in the subparafascicular area, the posterior intralaminar complex of the thalamus and the pontine medial paralemniscal nucleus...
  8. Varga T, Palkovits M, Usdin T, Dobolyi A. The medial paralemniscal nucleus and its afferent neuronal connections in rat. J Comp Neurol. 2008;511:221-37 pubmed publisher
    Previously, we described a cell group expressing tuberoinfundibular peptide of 39 residues (TIP39) in the lateral pontomesencephalic tegmentum, and referred to it as the medial paralemniscal nucleus (MPL)...
  9. Dobolyi A, Palkovits M, Usdin T. The TIP39-PTH2 receptor system: unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms. Prog Neurobiol. 2010;90:29-59 pubmed publisher
    b>Tuberoinfundibular peptide of 39 residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled parathyroid hormone 2 receptor (PTH2R)...

More Information

Publications33

  1. Coutellier L, Logemann A, Kuo J, Rusnak M, Usdin T. TIP39 modulates effects of novelty-induced arousal on memory. Genes Brain Behav. 2011;10:90-9 pubmed publisher
    b>Tuberoinfundibular peptide of 39 residues (TIP39) is a neuropeptide localized to neural circuits subserving emotional processing...
  2. Coutellier L, Logemann A, Rusnak M, Usdin T. Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development. J Neuroendocrinol. 2011;23:612-9 pubmed publisher
    ..Recent evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39) and its receptor, the parathyroid hormone 2 receptor (PTH2-R), contribute to these ..
  3. Cservenák M, Szabó Ã, Bodnár I, Lékó A, Palkovits M, Nagy G, et al. Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. Psychoneuroendocrinology. 2013;38:3070-84 pubmed publisher
    ..b>Tuberoinfundibular peptide of 39 residues (TIP39) may contribute to its effects on prolactin release and maternal motivation...
  4. Galloway T, Fletcher T, Thomas O, Lee B, Pilling L, Harries L. PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere. 2015;120:555-62 pubmed publisher
    ..between PFOA or PFOS serum levels and the in vivo expression of the Parathyroid hormone 1 and 2 genes (PTH, PTH2), Parathyroid hormone 1 and 2 receptor genes (PTH1R, PTH2R) and the parathyroid hormone-like (PTHLH) gene in ..
  5. Ferguson P, Holloway W, Setzer W, McFeeters H, McFeeters R. Small Molecule Docking Supports Broad and Narrow Spectrum Potential for the Inhibition of the Novel Antibiotic Target Bacterial Pth1. Antibiotics (Basel). 2016;5: pubmed publisher
    ..Overall, 83 compounds were docked to eight different bacterial Pth1 and three different Pth2 structures. A variety of compounds demonstrated favorable docking with Pths...
  6. Weaver R, Mobarec J, Wigglesworth M, Reynolds C, Donnelly D. High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochem Pharmacol. 2017;127:71-81 pubmed publisher
    TIP39 ("tuberoinfundibular peptide of 39 residues") acts via the parathyroid hormone 2 receptor, PTH2, a Family B G protein-coupled receptor (GPCR)...
  7. Sato E, Muto J, Zhang L, Adase C, Sanford J, Takahashi T, et al. The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation. J Invest Dermatol. 2016;136:1449-1459 pubmed publisher
    ..the expression and potential functions of the PTH second receptor (PTH2R) and its ligand, the tuberoinfundibular peptide of 39 residues (TIP39), in the skin...
  8. Cservenák M, Kis V, Keller D, Dimén D, Menyhárt L, Oláh S, et al. Maternally involved galanin neurons in the preoptic area of the rat. Brain Struct Funct. 2017;222:781-798 pubmed publisher
    ..Nerve terminals containing tuberoinfundibular peptide 39 (TIP39), a neuropeptide that mediates effects of suckling on maternal motivation, were abundant around galanin neurons in ..
  9. Delgado S, Deutsch D, Sire J. Evolutionary Analysis of the Mammalian Tuftelin Sequence Reveals Features of Functional Importance. J Mol Evol. 2017;84:214-224 pubmed publisher
    ..several, new, putatively functional domains and confirmed previously described functional domains, such as the TIP39 interaction domain, which correlates with nuclear localization of the TUFT1 protein, that was demonstrated in ..
  10. Sato E, Zhang L, Dorschner R, Adase C, Choudhury B, Gallo R. Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol. 2017;137:1774-1783 pubmed publisher
    In this study, we report that TIP39, a parathyroid hormone ligand family member that was recently identified to be expressed in the skin, can induce decorin expression and enhance wound repair...
  11. Tsuda M, Yeung H, Kuo J, Usdin T. Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala. J Neurosci. 2015;35:12152-61 pubmed publisher
    ..Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory...
  12. Cavalier E, Schleck M, Souberbielle J. Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays. Clin Chim Acta. 2018;477:72-73 pubmed publisher
    We report here an interference that has been observed with 2nd generation PTH assays (PTH2), but not with 3rd generation PTH ones (PTH3), during PTH monitoring occurring in a surgical intervention for the resection ..
  13. Wu X, Ruan J, Ma B, Luo M. Bit1-a potential positive regulator of epithelial-mesenchymal transition in lens epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2016;254:1311-8 pubmed publisher
    ..Suppressing Bit1 inhibits the proliferation, migration, and EMT of LECs. Bit1 may be a potential novel therapeutic target for the prevention and treatment of PCO. ..
  14. Bagó A, Dimitrov E, Saunders R, Seress L, Palkovits M, Usdin T, et al. Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. Neuroscience. 2009;162:128-47 pubmed publisher
    Parathyroid hormone receptor 2 (PTH2R) and its ligand, tuberoinfundibular peptide of 39 residues (TIP39) constitute a neuromodulator system implicated in endocrine and nociceptive regulation...
  15. Bisello A, Manen D, Pierroz D, Usdin T, Rizzoli R, Ferrari S. Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. Mol Endocrinol. 2004;18:1486-98 pubmed
    The human PTH receptor type 2 (PTH2R) is activated by PTH and tuberoinfundibular peptide of 39 residues (TIP39), resulting in cAMP and intracellular Ca signaling...
  16. Misiano P, Scott B, Scheideler M, Garnier M. PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation. Eur J Pharmacol. 2003;468:159-66 pubmed
    ..Using a cyclic AMP-responsive gene-reporter, we confirmed that the tuberoinfundibular peptide (TIP39) and various human (h) PTH fragments including hPTH-(1-34) were potent agonists (EC(50) in the range of 0.01-0...
  17. Hansen I, Jakob O, Wortmann S, Arzberger T, Allolio B, Blind E. Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family. J Endocrinol. 2002;174:95-102 pubmed
    The polypeptide TIP39 (tuberoinfundibular peptide of 39 residues) is a potent activator of the parathyroid hormone (PTH)-2 receptor (P2R) and an antagonist of the PTH-1 receptor (P1R)...
  18. Hoare S, Clark J, Usdin T. Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity. J Biol Chem. 2000;275:27274-83 pubmed
    b>Tuberoinfundibular peptide of 39 residues (TIP39) and the parathyroid hormone-2 (PTH2) receptor form part of an extended family of related signaling molecules that includes the PTH1 receptor, which responds to PTH and PTH-related protein...
  19. Della Penna K, Kinose F, Sun H, Koblan K, Wang H. Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor. Neuropharmacology. 2003;44:141-53 pubmed
    The neuropeptide TIP39 was recently purified from bovine hypothalamus based on the ability of the peptide to activate the parathyroid hormone 2 receptor (PTH2R) ( Nat. Neurosci. 2 (1999) 941)...
  20. John M, Arai M, Rubin D, Jonsson K, Juppner H. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology. 2002;143:1047-57 pubmed
    By screening public databases, we identified human and mouse genomic DNA clones that encode the tuberoinfundibular peptide of 39 residues (TIP39)...
  21. Sato E, Williams M, Sanford J, Sen G, Nakama T, Imafuku S, et al. The parathyroid hormone family member TIP39 interacts with sarco/endoplasmic reticulum Ca2+ - ATPase activity by influencing calcium homoeostasis. Exp Dermatol. 2017;26:792-797 pubmed publisher
    ..three-dimensional (3D) epidermal model of DD and use this model to evaluate peptide therapy with tuberoinfundibular peptide of 39 residues (TIP39) to normalize calcium transport...
  22. Dobolyi A, Ueda H, Uchida H, Palkovits M, Usdin T. Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci U S A. 2002;99:1651-6 pubmed
    ..b>Tuberoinfundibular peptide of 39 residues (TIP39) selectively activates the PTH2 receptor...
  23. Wilgus T. New Mechanisms of ECM Production during Wound Healing: A Role for Parathyroid Hormone 2 Receptor Signaling. J Invest Dermatol. 2017;137:1617-1619 pubmed publisher
    ..Deficiencies in PTH2R or its ligand tuberoinfundibular peptide of 39 residues (TIP39) delayed repair, and TIP39 treatment accelerated healing...
  24. Usdin T, Hoare S, Wang T, Mezey E, Kowalak J. TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Nat Neurosci. 1999;2:941-3 pubmed