Gene Symbol: PTH1R
Description: parathyroid hormone 1 receptor
Alias: PFE, PTHR, PTHR1, parathyroid hormone/parathyroid hormone-related peptide receptor, PTH/PTHr receptor, PTH/PTHrP type I receptor, PTH1 receptor, parathyroid hormone receptor 1, parathyroid hormone/parathyroid hormone-related protein receptor, seven transmembrane helix receptor
Species: human
Products:     PTH1R

Top Publications

  1. Schipani E, Kruse K, Juppner H. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science. 1995;268:98-100 pubmed
    ..This finding explains the severe ligand-independent hypercalcemia and hypophosphatemia, and most likely the abnormal formation of endochondral bone, in this rare form of short-limbed dwarfism. ..
  2. Jobert A, Zhang P, Couvineau A, Bonaventure J, Roume J, Le Merrer M, et al. Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. J Clin Invest. 1998;102:34-40 pubmed
    ..These findings emphasize the importance of signaling through this receptor in human fetal skeletal development. ..
  3. Liu P, Zhang Y, Lu Y, Long J, Shen H, Zhao L, et al. A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases. J Med Genet. 2005;42:221-7 pubmed
    ..rare haplotypes of the parathyroid hormone (PTH)/PTH related peptide receptor type 1 and vitamin D receptor genes (PTHR1 and VDR) with frequencies of 1.1% and 2...
  4. Mahon M, Bonacci T, Divieti P, Smrcka A. A docking site for G protein ?? subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways. Mol Endocrinol. 2006;20:136-46 pubmed
    The G protein-coupled receptor for PTH and PTH-related protein (PTH1R) signals via many intracellular pathways. The purpose of this work is to investigate a G protein binding site on an intracellular domain of the PTH1R...
  5. Castro M, Nikolaev V, Palm D, Lohse M, Vilardaga J. Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proc Natl Acad Sci U S A. 2005;102:16084-9 pubmed
    Parathyroid hormone (PTH) and its related receptor (PTHR) are essential regulators of calcium homeostasis and bone physiology...
  6. Vilariño Güell C, Miles L, Duncan E, Ralston S, Compston J, Cooper C, et al. PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton. Calcif Tissue Int. 2007;81:270-8 pubmed
    We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone mass or effects on subsequent bone ..
  7. Zhang P, Jobert A, Couvineau A, Silve C. A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia. J Clin Endocrinol Metab. 1998;83:3365-8 pubmed
  8. Vilardaga J, Krasel C, Chauvin S, Bambino T, Lohse M, Nissenson R. Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. J Biol Chem. 2002;277:8121-9 pubmed
    beta-Arrestins have been implicated in regulating internalization of the parathyroid hormone receptor (PTHR), but the structural features in the receptor required for this effect are unknown...
  9. Mahon M, Donowitz M, Yun C, Segre G. Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature. 2002;417:858-61 pubmed
    The parathyroid hormone 1 receptor (PTH1R) is a class II G-protein-coupled receptor...

More Information

Publications109 found, 100 shown here

  1. Gesty Palmer D, Chen M, Reiter E, Ahn S, Nelson C, Wang S, et al. Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J Biol Chem. 2006;281:10856-64 pubmed
    ..Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related peptide (PTH/PTHrP) receptor (PTH1R)...
  2. Scillitani A, Jang C, Wong B, Hendy G, Cole D. A functional polymorphism in the PTHR1 promoter region is associated with adult height and BMD measured at the femoral neck in a large cohort of young caucasian women. Hum Genet. 2006;119:416-21 pubmed
    The parathyroid hormone type 1 receptor (PTHR1) mediates the actions of parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHRP)...
  3. Dean T, Vilardaga J, Potts J, Gardella T. Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. Mol Endocrinol. 2008;22:156-66 pubmed
    PTH and PTHrP use the same G protein-coupled receptor, the PTH/PTHrP receptor (PTHR), to mediate their distinct biological actions. The extent to which the mechanisms by which the two ligands bind to the PTHR differ is unclear...
  4. Wang B, Bisello A, Yang Y, Romero G, Friedman P. NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. J Biol Chem. 2007;282:36214-22 pubmed
    ..The phenotype of NHERF1-null mice suggests that the parathyroid hormone (PTH) receptor (PTH1R) is the principal GPCR interacting with NHERF1. The effect of NHERF1 on receptor recycling is unknown...
  5. Okazaki M, Ferrandon S, Vilardaga J, Bouxsein M, Potts J, Gardella T. Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proc Natl Acad Sci U S A. 2008;105:16525-30 pubmed publisher
    The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor that plays critical roles in bone and mineral ion metabolism...
  6. Decker E, Stellzig Eisenhauer A, Fiebig B, Rau C, Kress W, Saar K, et al. PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Am J Hum Genet. 2008;83:781-6 pubmed publisher the gene encoding the G protein-coupled receptor for parathyroid hormone and parathyroid hormone-like hormone (PTHR1). Three distinct mutations, namely c.1050-3C > G, c.543+1G > A, and c...
  7. Frazier Bowers S, Simmons D, Wright J, Proffit W, Ackerman J. Primary failure of eruption and PTH1R: the importance of a genetic diagnosis for orthodontic treatment planning. Am J Orthod Dentofacial Orthop. 2010;137:160.e1-7; discussion 160-1 pubmed publisher
    ..Recent studies support that this dental phenotype is inherited and that mutations in PTH1R genes explain several familial cases of PFE...
  8. Wehbi V, Stevenson H, Feinstein T, Calero G, Romero G, Vilardaga J. Noncanonical GPCR signaling arising from a PTH receptor-arrestin-G?? complex. Proc Natl Acad Sci U S A. 2013;110:1530-5 pubmed publisher
    ..However, parathyroid hormone receptor type 1 (PTHR), an essential GPCR involved in bone and mineral metabolism, does not follow this conventional desensitization ..
  9. Karperien M, van der Harten H, van Schooten R, Farih Sips H, Den Hollander N, Kneppers S, et al. A frame-shift mutation in the type I parathyroid hormone (PTH)/PTH-related peptide receptor causing Blomstrand lethal osteochondrodysplasia. J Clin Endocrinol Metab. 1999;84:3713-20 pubmed
    ..Our results provide further evidence that BOCD is caused by inactivating mutations of the type I PTH/PTHrP receptor and underscore the importance of this receptor in mammalian skeletal development. ..
  10. Zhang Y, Liu P, Lu Y, Xiao P, Liu Y, Long J, et al. Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in Caucasians. J Bone Miner Metab. 2006;24:36-41 pubmed
    Parathyroid hormone/parathyroid hormone-related peptide receptor type 1 (PTHR1) plays an important role in calcium metabolism. It was previously shown to influence variation in bone mineral density (BMD)...
  11. Couvineau A, Wouters V, Bertrand G, Rouyer C, Gerard B, Boon L, et al. PTHR1 mutations associated with Ollier disease result in receptor loss of function. Hum Mol Genet. 2008;17:2766-75 pubmed publisher
    b>PTHR1-signaling pathway is critical for the regulation of endochondral ossification...
  12. Yamaguchi T, Hosomichi K, Narita A, Shirota T, Tomoyasu Y, Maki K, et al. Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese. J Bone Miner Res. 2011;26:1655-61 pubmed publisher
    ..Among the three variants, only a novel variant of parathyroid hormone 1 receptor gene (PTH1R), R383Q, was cosegregated in the first PFE family...
  13. Feinstein T, Wehbi V, Ardura J, Wheeler D, Ferrandon S, Gardella T, et al. Retromer terminates the generation of cAMP by internalized PTH receptors. Nat Chem Biol. 2011;7:278-84 pubmed publisher
    ..However, this paradigm is not consistent with recent observations that the parathyroid hormone receptor type 1 (PTHR) continues to stimulate cAMP production even after receptor internalization, as ?-arrestins are known to rapidly ..
  14. Mahon M. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Curr Drug Targets. 2012;13:116-28 pubmed
    The parathyroid hormone 1 receptor (PTH1R) is activated by parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP), hormones that mediate mineral ion homeostasis and tissue development, respectively...
  15. Isales C, Sumpio B, Bollag R, Zhong Q, Ding K, Du W, et al. Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line. Am J Physiol Endocrinol Metab. 2000;279:E654-62 pubmed
    ..In summary, these data demonstrate that endothelium-derived cells contain functional parathyroid hormone receptors. The potential physiological role of these receptors remains to be determined...
  16. Couvineau A, Laburthe M. The family B1 GPCR: structural aspects and interaction with accessory proteins. Curr Drug Targets. 2012;13:103-15 pubmed 1 and 2 receptors (GLPR), gastric inhibitory peptide receptor (GIPR), parathyroid hormone receptors (PTHR), calcitonin receptors (CTR) and corticotropin-releasing factor receptors (CRFR)...
  17. Yavropoulou M, Michopoulos A, Yovos J. PTH and PTHR1 in osteocytes. New insights into old partners. Hormones (Athens). 2017;16:150-160 pubmed publisher
    ..In this review we focus on the key roles of these receptors in osteoblasts and osteocytes, combining what is known and what is new regarding these interesting pleiotropic hormone receptors. ..
  18. Zhu M, Zhang J, Dong Z, Zhang Y, Wang R, Karaplis A, et al. The p27 Pathway Modulates the Regulation of Skeletal Growth and Osteoblastic Bone Formation by Parathyroid Hormone-Related Peptide. J Bone Miner Res. 2015;30:1969-79 pubmed publisher
    ..As well, protein expression levels of PTHR, IGF-1, and Bmi-1, and the numbers of total colony-forming unit fibroblastic (CFU-f) and ALP-positive CFU-f were ..
  19. Thi M, Urban Maldonado M, Spray D, Suadicani S. Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria. Am J Physiol Cell Physiol. 2010;299:C994-C1006 pubmed publisher
  20. Reis M, Matias D, Faria M, Martin R. Failure of tooth eruption and brachydactyly in pseudohypoparathyroidism are not related to plasma parathyroid hormone-related protein levels. Bone. 2016;85:138-41 pubmed publisher
    ..familial nonsyndromic PFE is caused by heterozygous mutations in the gene encoding the G protein-coupled receptor (PTH1R) for PTH and PTHrP...
  21. Wang W, Lian N, Li L, Moss H, Wang W, Perrien D, et al. Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development. 2009;136:4143-53 pubmed publisher
    ..whereas the expression of other chondrocyte marker genes, such as type II collagen (Col2a1), PTH/PTHrP receptor (Pth1r) and type X collagen (Col10a1), is normal...
  22. Frieling J, Shay G, Izumi V, Aherne S, Saul R, Budzevich M, et al. Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP1-17. Oncogene. 2017;36:4498-4507 pubmed publisher
    ..PTHrP1-17 retains the ability to signal through PTH1R to induce calcium flux and ERK phosphorylation but not cyclic AMP production or CREB phosphorylation...
  23. Fan Y, Hanai J, Le P, Bi R, Maridas D, DeMambro V, et al. Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017;25:661-672 pubmed publisher
    ..We genetically deleted the PTH/PTHrP receptor (PTH1R) in mesenchymal stem cells using Prx1Cre and found low bone formation, increased bone resorption, and high bone ..
  24. Bastepe M, Turan S, He Q. Heterotrimeric G proteins in the control of parathyroid hormone actions. J Mol Endocrinol. 2017;58:R203-R224 pubmed publisher
    ..This calciotropic hormone exerts its actions via binding to the PTH/PTH-related peptide receptor (PTH1R), which couples to multiple heterotrimeric G proteins, including Gs and Gq/11 Genetic ..
  25. Lumachi F, Motta R, Cecchin D, Ave S, Camozzi V, Basso S, et al. Calcium metabolism & hypercalcemia in adults. Curr Med Chem. 2011;18:3529-36 pubmed
    ..The PTH receptor in bone and kidney is now referred as PTHR1. The balance of PTH, calcitonin, and vitamin D has long been considered the main regulator of calcium metabolism, ..
  26. Dorotheou D, Farsadaki V, Bochaton Piallat M, Giannopoulou C, Halazonetis T, Kiliaridis S. Increased Cell Proliferation and Gene Expression of Genes Related to Bone Remodeling, Cell Adhesion and Collagen Metabolism in the Periodontal Ligament of Unopposed Molars in Growing Rats. Front Physiol. 2017;8:75 pubmed publisher
    ..Nine untreated rats served as controls. Expression of six genes, Adamts18, Ostn, P4ha3, Panx3, Pth1r, and Tnmd, was upregulated in unopposed molars relative to molars with antagonists...
  27. Dale M, Mortimer E, Kolli S, Achramowicz E, Borchert G, Juliano S, et al. Bone-remodeling transcript levels are independent of perching in end-of-lay white leghorn chickens. Int J Mol Sci. 2015;16:2663-77 pubmed publisher
    ..1), RANKL (receptor activator of nuclear factor kappa-B ligand), OPG (osteoprotegerin), PTHLH (PTH-like hormone), PTH1R (PTH/PTHLH type-1 receptor), PTH3R (PTH/PTHLH type-3 receptor), and SOX9 (Sry-related high mobility group box)) in ..
  28. Luttrell L, Maudsley S, Gesty Palmer D. Translating in vitro ligand bias into in vivo efficacy. Cell Signal. 2018;41:46-55 pubmed publisher
    ..Transcriptomic analysis of tissue from treated animals suggests that conventional and arrestin pathway-selective PTH1R ligands act in largely different ways, with the latter principally affecting pathways involved in the regulation ..
  29. Moszczynski A, Strong W, Xu K, McKee A, Brown A, Strong M. Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS. Neurology. 2018;90:e380-e387 pubmed publisher other tauopathies of pathologic phosphorylation of microtubule-associated protein tau at Thr175 (pThr175 tau) and Thr231 (pThr231 tau), and glycogen synthase kinase-3β (GSK3β) ..
  30. Dackiw A, Pan J, Xu G, Yeung S. Modulation of parathyroid hormone-related protein levels (PTHrP) in anaplastic thyroid cancer. Surgery. 2005;138:456-63 pubmed
    ..These data suggest that PTHrP has a novel role in anaplastic thyroid cancer and that modulation of PTHrP levels may be of therapeutic benefit in this lethal malignancy. ..
  31. Zhang Y, Yang R, Huang J, Liang Q, Guo Y, Bian W, et al. Michael addition of dehydroalanine-containing MAPK peptides to catalytic lysine inhibits the activity of phosphothreonine lyase. FEBS Lett. 2015;589:3648-53 pubmed publisher
    ..lyases OspF and SpvC irreversibly inactivate host dual-phosphorylated mitogen-activated protein kinases (MAPKs) [pThr-X-pTyr motif] through β-elimination...
  32. Moszczynski A, Yang W, Hammond R, Ang L, Strong M. Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies. Acta Neuropathol Commun. 2017;5:6 pubmed publisher
    ..To determine the extent to which this pathway is unique to ALS, we have investigated the expression of pThr175 tau and pThr231 tau across a range of frontotemporal degenerations...
  33. Yang H, Ahn C, Shin E, Lee J, An B, Jeung E. NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model. Mol Cell Endocrinol. 2017;454:93-102 pubmed publisher
    ..Renal- and duodenal expression of PTHR and VDR were not changed; however, GR mRNA expression was increased in the kidney of NCKX3 KO mice...
  34. Hanisch M, Hanisch L, Kleinheinz J, Jung S. Primary failure of eruption (PFE): a systematic review. Head Face Med. 2018;14:5 pubmed publisher
    ..Additional dental anomalies were observed in 39 patients. A total of 51 different variants of the PTH1R gene associated with PFE were recorded...
  35. Guo X, Zuo H, Cao C, Zhang Y, Geng D, Zhang Z, et al. Abnormal expression of Col X, PTHrP, TGF-beta, bFGF, and VEGF in cartilage with Kashin-Beck disease. J Bone Miner Metab. 2006;24:319-28 pubmed
  36. McKinstry W, Polekhina G, Diefenbach Jagger H, Ho P, Sato K, Onuma E, et al. Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor. J Biol Chem. 2009;284:15557-63 pubmed publisher
    ..Antibodies have been developed that neutralize the action of PTHrP through its receptor, parathyroid hormone receptor 1, without influencing parathyroid hormone action through the same receptor...
  37. Zhou S, Bueno E, Kim S, Amato I, Shen L, Hahne J, et al. Effects of age on parathyroid hormone signaling in human marrow stromal cells. Aging Cell. 2011;10:780-8 pubmed publisher
    ..There were age-related decreases in expression of PTH/PTHrP receptor type 1 (PTHR1) gene (P?=?0.049, n?=?19) and in PTH activation of CREB (P?=?0...
  38. Alonso V, Magyar C, Wang B, Bisello A, Friedman P. Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting. J Bone Miner Res. 2011;26:2923-34 pubmed publisher
    Parathyroid hormone receptors (PTHR) are promptly internalized upon stimulation by activating (PTH[1-84], PTH[1-34]) and non-activating (PTH[7-84], PTH[7-34]) ligands...
  39. Charest Morin X, Fortin J, Lodge R, Allaeys I, Poubelle P, Marceau F. A tagged parathyroid hormone derivative as a carrier of antibody cargoes transported by the G protein coupled PTH1 receptor. Peptides. 2014;60:71-9 pubmed publisher
    ..The functional properties and potential of this analog for imaging PTH1R-expressing cells were examined...
  40. Yang Y, Lei H, Qiang Y, Wang B. Ixazomib enhances parathyroid hormone-induced ?-catenin/T-cell factor signaling by dissociating ?-catenin from the parathyroid hormone receptor. Mol Biol Cell. 2017;28:1792-1803 pubmed publisher
    ..Catenin switches the PTH receptor (PTHR) signaling from cAMP/PKA to PLC/PKC activation by binding to the PTHR...
  41. Grauschopf U, Lilie H, Honold K, Wozny M, Reusch D, Esswein A, et al. The N-terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide pattern. Biochemistry. 2000;39:8878-87 pubmed
    ..To obtain structural and functional information on the N-terminal receptor fragment of human parathyroid hormone receptor 1 (PTHR1), the truncated receptor was expressed in the cytosol of Escherichia coli in the form of ..
  42. Conlan L, Martin T, Gillespie M. The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B. FEBS Lett. 2002;527:71-5 pubmed
    ..These findings suggest that beta-arrestin 1 acts as an effector for a novel function of PTHrP in cytoplasm. ..
  43. Pioszak A, Xu H. Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proc Natl Acad Sci U S A. 2008;105:5034-9 pubmed publisher
    ..It acts primarily by binding to its receptor, PTH1R, a member of the class B G protein-coupled receptor (GPCR) family that also includes receptors for glucagon, ..
  44. Zhang Y, Frangos J, Chachisvilis M. Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells. Am J Physiol Cell Physiol. 2009;296:C1391-9 pubmed publisher transfer (FRET), we investigated conformational transitions in parathyroid hormone type 1 receptor (PTH1R)...
  45. Houpis C, Tosios K, Papavasileiou D, Christopoulos P, Koutlas I, Sklavounou A, et al. Parathyroid hormone-related peptide (PTHrP), parathyroid hormone/parathyroid hormone-related peptide receptor 1 (PTHR1), and MSX1 protein are expressed in central and peripheral giant cell granulomas of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:415-24 pubmed publisher
    Parathyroid hormone-related peptide (PTHrP) binds to the parathyroid hormone receptor type 1 (PTHR1), which results in the activation of pathways in osteoblasts that promote osteoclastogenesis through the RANK/RANKL system...
  46. Cheng S, Shao J, Halstead L, Distelhorst K, Sierra O, Towler D. Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res. 2010;107:271-82 pubmed publisher
    ..We sought to determine the impact of vascular PTH receptor (PTH1R) activity on arteriosclerotic Wnt/beta-catenin signaling in vitro and in vivo...
  47. López Úbeda R, García Vázquez F, Romar R, Gadea J, Muñoz M, Hunter R, et al. Oviductal Transcriptome Is Modified after Insemination during Spontaneous Ovulation in the Sow. PLoS ONE. 2015;10:e0130128 pubmed publisher
    ..Network 3 integrated the genes with the highest down-regulation level (CYP51, PTH1R and TMOD3)...
  48. Hashimoto H, Azuma Y, Kawasaki M, Fujihara H, Onuma E, Yamada Okabe H, et al. Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides. Clin Cancer Res. 2007;13:292-8 pubmed
  49. Yang R, Hoang B, Kubo T, Kawano H, Chou A, Sowers R, et al. Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. Int J Cancer. 2007;121:943-54 pubmed
    ..Parathyroid hormone-related peptide (PTHrP) signaling via parathyroid hormone Type 1 receptor (PTHR1) is important for skeletal development and is involved in bone metastases in other tumors...
  50. Klenk C, Schulz S, Calebiro D, Lohse M. Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1. J Biol Chem. 2010;285:8665-74 pubmed publisher
    The receptor for parathyroid hormone (PTHR) is a main regulator of calcium homeostasis and bone maintenance...
  51. Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung U, et al. ?-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor. Arthritis Rheum. 2013;65:429-35 pubmed publisher
    ..The ?-catenin-PTHR-1 binding region was determined with deletion and mutagenesis analyses of the PTHR1 C-terminus, using a mammalian two-hybrid assay...
  52. Rajamohan F, Reyes A, Frisbie R, Hoth L, Sahasrabudhe P, Magyar R, et al. Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators. Biochem J. 2016;473:581-92 pubmed publisher
    ..more sensitive than α1-complexes to dephosphorylation of a critical threonine on their activation loop (pThr(172/174)). However, α2-complexes were more readily activated by AMP than α1-complexes...
  53. Graciolli F, Neves K, Barreto F, Barreto D, dos Reis L, Canziani M, et al. The complexity of chronic kidney disease-mineral and bone disorder across stages of chronic kidney disease. Kidney Int. 2017;91:1436-1446 pubmed publisher
    ..Thus, our studies help define the complex mechanism of bone and mineral metabolism in patients with CKD. Linkage of serum markers to bone expression of specific proteins may facilitate our understanding and management of this disease. ..
  54. Liang H, Zhong Y, Huang Y, Chen G. Type 1 receptor parathyroid hormone (PTH1R) influences breast cancer cell proliferation and apoptosis induced by high levels of glucose. Med Oncol. 2012;29:439-45 pubmed publisher
    ..We investigated the effect of type 1 receptor parathyroid hormone (PTH1R) expression on viability and apoptosis of breast cancer cells exposed to high levels of glucose...
  55. Hocher B, Oberthür D, Slowinski T, Querfeld U, Schaefer F, Doyon A, et al. Modeling of oxidized PTH (oxPTH) and non-oxidized PTH (n-oxPTH) receptor binding and relationship of oxidized to non-oxidized PTH in children with chronic renal failure, adult patients on hemodialysis and kidney transplant recipients. Kidney Blood Press Res. 2013;37:240-51 pubmed publisher
    ..The iPTH measures describes most likely oxidative stress in patients with renal failure rather than the PTH hormone status. This, however, needs to be demonstrated in further clinical studies. © 2013 S. Karger AG, Basel. ..
  56. McGarvey J, Xiao K, Bowman S, Mamonova T, Zhang Q, Bisello A, et al. Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling. J Biol Chem. 2016;291:10986-1002 pubmed publisher
    The G protein-coupled parathyroid hormone receptor (PTHR) regulates mineral-ion homeostasis and bone remodeling...
  57. Delgado Calle J, Tu X, Pacheco Costa R, McAndrews K, Edwards R, Pellegrini G, et al. Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor. J Bone Miner Res. 2017;32:522-535 pubmed publisher
    ..We report here that mice with conditional deletion of the parathyroid hormone (PTH) receptor 1 (Pth1r) in dentin matrix protein 1 (DMP1)-8kb-expressing cells (cKO) exhibit a modest decrease in bone resorption leading ..
  58. Doyle N, Varela A, Haile S, Guldberg R, Kostenuik P, Ominsky M, et al. Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption. Osteoporos Int. 2018;29:685-697 pubmed publisher
    Abaloparatide, a novel PTH1 receptor agonist, increased bone formation in osteopenic ovariectomized cynomolgus monkeys while increasing cortical and trabecular bone mass...
  59. Znorko B, Pawlak D, Oksztulska Kolanek E, Domaniewski T, Pryczynicz A, Roszczenko A, et al. RANKL/OPG system regulation by endogenous PTH and PTH1R/ATF4 axis in bone: Implications for bone accrual and strength in growing rats with mild uremia. Cytokine. 2018;106:19-28 pubmed publisher
    ..Gene expression of parathyroid hormone 1 receptor (PTH1R) and activating transcription factor 4 (ATF4), major regulators of anabolic PTH response in bone, was also ..
  60. Bertran Vicente J, Schümann M, Schmieder P, Krause E, Hackenberger C. Direct access to site-specifically phosphorylated-lysine peptides from a solid-support. Org Biomol Chem. 2015;13:6839-43 pubmed publisher
    ..The impact of phospho-serine (pSer), -threonine (pThr) and -tyrosine (pTyr) is certainly understood for some proteins...
  61. Venegas L, Pershad K, Bankole O, Shah N, Kay B. A comparison of phosphospecific affinity reagents reveals the utility of recombinant Forkhead-associated domains in recognizing phosphothreonine-containing peptides. N Biotechnol. 2016;33:537-43 pubmed publisher
    ..66% success rate); success was largely determined by what residue occurred at the +3 position (C-terminal) to the pThr moiety (i.e., pT+3)...
  62. Gensure R, Shimizu N, Tsang J, Gardella T. Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor. Mol Endocrinol. 2003;17:2647-58 pubmed
    ..The findings also support a molecular model in which the 1-21 region of PTH binds to the extracellular face of the P1R J domain as an alpha-helix. ..
  63. D uva M, Di Micco P, Strina I, Ranieri A, Alviggi C, Mollo A, et al. Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: new clinical target for antithrombotic therapy. Biologics. 2008;2:897-902 pubmed
    ..Because these patients often also show a hypercoagulable state, it an antithrombotic treatment before and during pregnancy may improve their clinical outcome (ie, secondary prevention of miscarriage and primary thromboprophylaxis). ..
  64. Monego G, Lauriola L, Ramella S, D Angelillo R, Lanza P, Granone P, et al. Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma. Chest. 2010;137:898-908 pubmed publisher
    In many primary tumors, parathyroid hormone-related peptide (PTHrP) and PTHrP type 1 receptor (PTH1R) are coexpressed, supporting the possibility that PTHrP/PTH1R system can mediate important signals for tumor progression through ..
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    The parathyroid hormone receptor (PTH1R) is a class B G protein-coupled receptor that is activated by parathyroid hormone (PTH) and PTH-related protein (PTHrP)...
  66. Yin Y, de Waal P, He Y, Zhao L, Yang D, Cai X, et al. Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors. J Biol Chem. 2017;292:9865-9881 pubmed publisher
    ..Importantly, mutations in the corresponding polar core of several other members of class B GPCRs, including PTH1R, PAC1R, VIP1R, and CRFR1, also induce constitutive G protein signaling, suggesting that the rearrangement of the ..
  67. Li S, Dong Y, Wang K, Wang Z, Zhang X. Transcriptomic analyses reveal the underlying pro-malignant functions of PTHR1 for osteosarcoma via activation of Wnt and angiogenesis pathways. J Orthop Surg Res. 2017;12:168 pubmed publisher
    Increasing evidence has indicated parathyroid hormone type 1 receptor (PTHR1) plays important roles for the development and progression of osteosarcoma (OS). However, its function mechanisms remain unclear...
  68. Schipani E, Jensen G, Pincus J, Nissenson R, Gardella T, Juppner H. Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia. Mol Endocrinol. 1997;11:851-8 pubmed
    ..These studies suggest that two residues in the human PTH/PTHrP receptor, 223 and 410, have critical roles in signal transduction, but with different sequence constrains. ..
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    ..acid fragment of the extracellular N-terminus of the human G-protein coupled receptor for parathyroid hormone (PTH1R) has been structurally characterized by NMR and molecular dynamics simulations...
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    ..The NMR data presented in the accompanying manuscript suggests that this role could involve intramolecular effects on secondary structure in the N-terminal portion of the ligand. ..
  73. Ono N, Nakashima K, Schipani E, Hayata T, Ezura Y, Soma K, et al. Constitutively active parathyroid hormone receptor signaling in cells in osteoblastic lineage suppresses mechanical unloading-induced bone resorption. J Biol Chem. 2007;282:25509-16 pubmed
    ..These results indicated that constitutive activation of PTH/PTHrP receptor signaling in osteoblastic cells suppresses unloading-induced bone loss specifically through the regulation of osteoclastic activity. ..
  74. Shen X, Mula R, Li J, Weigel N, Falzon M. PTHrP contributes to the anti-proliferative and integrin alpha6beta4-regulating effects of 1,25-dihydroxyvitamin D(3). Steroids. 2007;72:930-8 pubmed
    ..These findings suggest that one of the pathways via which 1,25(OH)(2)D(3) exerts its anti-proliferative effects is through down-regulation of PTHrP expression. ..
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    Type 1 parathyroid hormone receptor (PTH1R) activation, desensitization, internalization, and recycling proceed in a cyclical manner...
  76. Mahon M. The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells. Mol Endocrinol. 2009;23:1691-701 pubmed publisher
    PTH 1 receptor (PTH1R) regulates mineral ion homeostasis. Both apical and basolateral PTH1R subpopulations exist within the renal proximal tubule...
  77. Klenk C, Vetter T, Zürn A, Vilardaga J, Friedman P, Wang B, et al. Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid hormone receptor. J Biol Chem. 2010;285:30355-62 pubmed publisher
    ..methods we investigated the interplay among NHERF1, ?-arrestin2, and the parathyroid hormone receptor type 1 (PTHR)...
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    ..fluorescence anisotropy technique showed that EPA and DHA competitively bind to and alter the affinity of PTH1 receptor to PTH(1-34) leading to a superagonistic response...
  79. Ho P, Goradia A, Russell M, Chalk A, Milley K, Baker E, et al. Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo. Oncogene. 2015;34:2922-33 pubmed publisher
    ..Using a murine OS model, we found that OS cells express PTHrP and the common PTH/PTHrP receptor (PTHR1). To investigate the role of PTHR1 signaling in OS cell behavior, we used shRNA to reduce PTHR1 expression...
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  81. Nampoothiri S, Fernández Rebollo E, Yesodharan D, Gardella T, Rush E, Langman C, et al. Jansen Metaphyseal Chondrodysplasia due to Heterozygous H223R-PTH1R Mutations With or Without Overt Hypercalcemia. J Clin Endocrinol Metab. 2016;101:4283-4289 pubmed
    ..Five different heterozygous activating PTH/PTHrP receptor (PTH1R) mutations that change one of three different amino acid residues are known to cause JMC...
  82. Pausova Z, Bourdon J, Clayton D, Mattei M, Seldin M, Janicic N, et al. Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes. Genomics. 1994;20:20-6 pubmed
    ..DNAs spanning the entire coding region of the rat parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) were isolated from a rat osteosarcoma (UMR 106) cell-line cDNA library...
  83. Schipani E, Langman C, Hunzelman J, Le Merrer M, Loke K, Dillon M, et al. A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia. J Clin Endocrinol Metab. 1999;84:3052-7 pubmed
    ..Overall, the patient with the I458R mutation exhibited clinical and biochemical abnormalities similar to those in patients with the previously identified H223R and T410P mutations. ..
  84. Funk J, Wei H, Downey K, Yocum D, Benjamin J, Carley W. Expression of PTHrP and its cognate receptor in the rheumatoid synovial microcirculation. Biochem Biophys Res Commun. 2002;297:890-7 pubmed
    ..are consistent with a possible paracrine pathway for PTHrP action in the synovial microcirculation, wherein PTHrP peptides secreted by the synovial endothelium could act on surrounding PTH1R-positive pericytes and smooth muscle cells.
  85. Fröhlich L, Gensure R, Schipani E, Juppner H, Bastepe M. Haplotype frequencies and linkage disequilibrium analysis of four frequent polymorphisms at the PTH/PTH-related peptide receptor gene locus. Mol Cell Probes. 2004;18:353-7 pubmed
    ..This receptor is encoded by a single gene (PTHR1) on chromosome 3p21.1-p24...
  86. Saito M, Sugai M, Katsushima Y, Yanagisawa T, Sukegawa J, Nakahata N. Increase in cell-surface localization of parathyroid hormone receptor by cytoskeletal protein 4.1G. Biochem J. 2005;392:75-81 pubmed
    ..searched for proteins that interact with the C-terminus of PTH (parathyroid hormone)/PTH-related protein receptor (PTHR) by using the yeast two-hybrid system, and identified a cytoskeletal protein 4.1G (generaltype 4...
  87. Rey A, Manen D, Rizzoli R, Caverzasio J, Ferrari S. Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation. J Biol Chem. 2006;281:38181-8 pubmed
    ..By using a targeted mutagenesis approach, we investigated the PTH/PTH-related protein receptor (PTH1R) structural determinants for ERK1/2 activation and transcriptional activity in HEK-293 cells...
  88. Ardura J, Wang B, Watkins S, Vilardaga J, Friedman P. Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains. J Biol Chem. 2011;286:35020-9 pubmed publisher
    ..The parathyroid hormone receptor (PTHR), which regulates mineral ion homeostasis and bone turnover, is a G protein-coupled receptor harboring a PDZ-..
  89. Abuduwali N, Lossdörfer S, Winter J, Kraus D, Guhlke S, Wolf M, et al. Functional characterization of the parathyroid hormone 1 receptor in human periodontal ligament cells. Clin Oral Investig. 2014;18:461-70 pubmed publisher
    ..The dual actions of PTH are mediated primarily through the parathyroid hormone 1 receptor (PTH1R)...
  90. Roth H, Fritsche L, Meier C, Pilz P, Eigenthaler M, Meyer Marcotty P, et al. Expanding the spectrum of PTH1R mutations in patients with primary failure of tooth eruption. Clin Oral Investig. 2014;18:377-84 pubmed publisher
    ..Heterozygous mutations in the parathyroid hormone 1 receptor (PTH1R) gene have been shown to cause PFE likely due to protein haploinsufficiency...
  91. Zhu W, Hu X, Xu J, Cheng Y, Shao Y, Peng Y. Effect of PI3K/Akt Signaling Pathway on the Process of Prostate Cancer Metastasis to Bone. Cell Biochem Biophys. 2015;72:171-7 pubmed publisher
    ..Interaction of prostate cancer cells with bone cells has a stimulatory effect on cell proliferation. ..
  92. Wu S, Yang S, Chen H, Peng F, Yu H, Krepinsky J, et al. Dual roles of parathyroid hormone related protein in TGF-?1 signaling and fibronectin up-regulation in mesangial cells. Biosci Rep. 2017;37: pubmed publisher
    ..Our results showed that PTHrP treatment (?3 h) induced internalization of PTH1R (PTH/PTHrP receptor)-T?RII (TGF-? type 2 receptor) complex and suppressed TGF-?1-mediated Smad2/3 activation and ..