PTGS1

Summary

Gene Symbol: PTGS1
Description: prostaglandin-endoperoxide synthase 1
Alias: COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS, prostaglandin G/H synthase 1, PGH synthase 1, cyclooxygenase-1, prostaglandin H2 synthase 1, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Species: human
Products:     PTGS1

Top Publications

  1. Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A. 1992;89:7384-8 pubmed
    ..High-level induction of the hCox-2 transcript in mesenchymal-derived inflammatory cells suggests a role in inflammatory conditions. ..
  2. Otto J, DeWitt D, Smith W. N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum. J Biol Chem. 1993;268:18234-42 pubmed
    ..A similar orientation is predicted for PGH synthase-2. ..
  3. Sales K, Katz A, Howard B, Soeters R, Millar R, Jabbour H, et al. Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. Cancer Res. 2002;62:424-32 pubmed
    ..It is likely that similar mechanisms may act in vivo to modulate tumorigenesis of cervical carcinomas. ..
  4. Hasturk S, Kemp B, Kalapurakal S, Kurie J, Hong W, Lee J. Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma. Cancer. 2002;94:1023-31 pubmed
    ..Nevertheless, considering the patterns of Cox 1 and Cox 2 expression in tumor cells, Cox expression status may be a useful parameter when designing treatment strategies for a subset of NSCLC patients. ..
  5. Halushka M, Walker L, Halushka P. Genetic variation in cyclooxygenase 1: effects on response to aspirin. Clin Pharmacol Ther. 2003;73:122-30 pubmed
    ..toward that goal by combining polymorphism detection with functional assays for the therapeutic target gene cyclooxygenase 1 (COX-1)...
  6. Kino Y, Kojima F, Kiguchi K, Igarashi R, Ishizuka B, Kawai S. Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2. Prostaglandins Leukot Essent Fatty Acids. 2005;73:103-11 pubmed
    ..These findings suggest that COX-1 might be a major enzyme regulating PGE2 production in ovarian cancer cells. ..
  7. DeLong C, Smith W. An intronic enhancer regulates cyclooxygenase-1 gene expression. Biochem Biophys Res Commun. 2005;338:53-61 pubmed
    ..Our results suggest that inducible PGHS-1 gene expression involves the coordinate functioning of a Sp1 site in the promoter and an AP-1 site in intron 8. ..
  8. Kranzhofer R, Ruef J. Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism. Platelets. 2006;17:163-9 pubmed
    ..However, a correlation exists to elevated eicosanoids generated by oxidative stress indicating COX-1-independent pathways for the generation of platelet activating molecules represent a potential cause for AR. ..
  9. Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, et al. Association between genetic polymorphisms in the cyclooxygenase-1 gene promoter and peptic ulcers in Japan. Int J Mol Med. 2007;20:373-8 pubmed

More Information

Publications131 found, 100 shown here

  1. Malkowski M, Ginell S, Smith W, Garavito R. The productive conformation of arachidonic acid bound to prostaglandin synthase. Science. 2000;289:1933-7 pubmed
  2. Kunicki T, Williams S, Nugent D, Harrison P, Segal H, Syed A, et al. Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease. Thromb Haemost. 2009;101:123-33 pubmed
    ..Ibalpha and VI (GPIBA and GP6), the purinergic receptor P2Y1 (P2RY1), and prostaglandin H synthase 1 (PTGS1 = COX1)...
  3. Yim J, Cho H, Rabkin S. Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension. Clin Exp Hypertens. 2017;:1-12 pubmed publisher
    ..metallopeptidase 14 (MMP14), angiotensinogen (AGT), angiotensin II receptor Type 1 (AT1R), cytochrome C oxidase I (COX1), fms-like tyrosine kinase 1 (FLT1), TIMP metallopeptidase inhibitor 2 (TIMP2), phospholamban (PLN), vascular cell ..
  4. Uni S, Mat Udin A, Agatsuma T, Saijuntha W, Junker K, Ramli R, et al. Morphological and molecular characteristics of Malayfilaria sofiani Uni, Mat Udin & Takaoka n. g., n. sp. (Nematoda: Filarioidea) from the common treeshrew Tupaia glis Diard & Duvaucel (Mammalia: Scandentia) in Peninsular Malaysia. Parasit Vectors. 2017;10:194 pubmed publisher
    ..characteristics and determined the partial sequences of their mitochondrial cytochrome c oxidase subunit 1 (cox1) and 12S rRNA genes...
  5. Hassan Z, Meerkhan A, Boufana B, Hama A, Ahmed B, Mero W, et al. Two haplotype clusters of Echinococcus granulosus sensu stricto in northern Iraq (Kurdistan region) support the hypothesis of a parasite cradle in the Middle East. Acta Trop. 2017;172:201-207 pubmed publisher
    ..for Iraqi Kurdistan were seen for the Middle East, Europe, Mongolia, Russia and Tunisia using both 827bp and 1609bp cox1 nucleotide sequences, whereas a star-like network was observed for China and South America...
  6. Basso W, Grandt L, Magnenat A, Gottstein B, Campos M. Strongyloides stercoralis infection in imported and local dogs in Switzerland: from clinics to molecular genetics. Parasitol Res. 2019;118:255-266 pubmed publisher
    ..18S rDNA (fragment involving hypervariable regions I and IV) and the mitochondrial cytochrome oxidase subunit I (cox1) loci, similar to that of zoonotic isolates from other geographical regions, and not to that of dog-adapted ..
  7. Sun X, WANG L, Feng Y, Xie H, Zheng X, He A, et al. A case report: A rare case of infant gastrointestinal canthariasis caused by larvae of Lasioderma serricorne (Fabricius, 1792) (Coleoptera: Anobiidae). Infect Dis Poverty. 2016;5:34 pubmed publisher
    ..studied morphologically using naked eyes and anatomical lens, PCR analyzed targeting cytochrome oxidase subunit 1 (COX1) and 18S rRNA genes, examined by sequence analyses of the PCR products and finally classified by phylogenetic ..
  8. Kolondra A, Labedzka Dmoch K, Wenda J, Drzewicka K, Golik P. The transcriptome of Candida albicans mitochondria and the evolution of organellar transcription units in yeasts. BMC Genomics. 2015;16:827 pubmed publisher
    ..Transcriptome analysis allowed to precisely annotate the positions of introns in the RNL (2), COB (2) and COX1 (4) genes, as well as to refine the annotation of tRNAs and rRNAs...
  9. Annoscia G, Latrofa M, Cantacessi C, Olivieri E, Manfredi M, Dantas Torres F, et al. A new PCR assay for the detection and differentiation of Babesia canis and Babesia vogeli. Ticks Tick Borne Dis. 2017;8:862-865 pubmed publisher
    ..and developed a novel polymerase chain reaction (PCR) assay targeting the parasite cytochrome c oxidase subunit 1 (cox1) gene, for the simultaneous detection and differentiation of B. canis and B. vogeli...
  10. Qiao Y, Fan G, Guo J, Gao S, Zhao R, Yang X. Effects of adipokine zinc-α2-glycoprotein on adipose tissue metabolism after dexamethasone treatment. Appl Physiol Nutr Metab. 2019;44:83-89 pubmed publisher
    ..In conclusion, ZAG could alleviate DEX-induced decrease in plasma NEFA levels and this could be associated with the promoting lipid mobilization in WAT. ..
  11. Rojas A, Dvir E, Farkas R, Sarma K, Borthakur S, Jabbar A, et al. Phylogenetic analysis of Spirocerca lupi and Spirocerca vulpis reveal high genetic diversity and intra-individual variation. Parasit Vectors. 2018;11:639 pubmed publisher
    ..37-9.33%) and the cytochrome c oxidase subunit 1 (cox1) gene (1.42-6.74%). This genetic diversity led to the identification of two S...
  12. Heinonen S, Muniandy M, Buzková J, Mardinoglu A, Rodríguez A, Frühbeck G, et al. Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins. Diabetologia. 2017;60:169-181 pubmed
    ..We confirmed that mitochondrial DNA transcript levels (12S RNA, 16S RNA, COX1, ND5, CYTB), expression of mitochondrial ribosomal protein transcripts and a major mitochondrial regulator PGC-1α..
  13. Ho H, Hsu S, Lee F, Huang H, Hsin I, Hou M, et al. Role of cyclooxygenase isoforms in encephalopathy of cirrhotic rats. J Chin Med Assoc. 2016;79:583-588 pubmed publisher
    ..aimed at surveying the roles of cyclooxygenase isoforms responsible for prostaglandins synthesis, cyclooxygenase-1 (COX1) and COX2, in cirrhotic rats with HE...
  14. Mihalca A, Ionică A, D Amico G, Daskalaki A, Deak G, Matei I, et al. Thelazia callipaeda in wild carnivores from Romania: new host and geographical records. Parasit Vectors. 2016;9:350 pubmed publisher
    ..If present, all nematodes were collected in absolute ethanol (for molecular analysis of the partial cox1 gene) or in 4 % formalin (for morphological identification)...
  15. Taguchi K, Hamamoto S, Okada A, Unno R, Kamisawa H, Naiki T, et al. Genome-Wide Gene Expression Profiling of Randall's Plaques in Calcium Oxalate Stone Formers. J Am Soc Nephrol. 2017;28:333-347 pubmed publisher
    ..Compared with non-RP tissue, RP tissue showed upregulation (?2-fold) of LCN2, IL11, PTGS1, GPX3, and MMD and downregulation (0.5-fold) of SLC12A1 and NALCN (P<0.01)...
  16. Hornok S, Beck R, Farkas R, Grima A, Otranto D, Kontschán J, et al. High mitochondrial sequence divergence in synanthropic flea species (Insecta: Siphonaptera) from Europe and the Mediterranean. Parasit Vectors. 2018;11:221 pubmed publisher
    ..ten species of eight genera, were used for PCR amplification of part of their cytochrome c oxidase subunits 1, 2 (cox1, cox2) and 18S rRNA genes, followed by sequencing and phylogenetic analyses. The majority (65.6%) of Ct...
  17. Jiang J, Hu G, Zhang C, Zhao X, Wang Q, Chen L. Toxicological analysis of triadimefon on endocrine disruption and oxidative stress during rare minnow (Gobiocypris rarus) larvae development. Environ Sci Pollut Res Int. 2017;24:26681-26691 pubmed publisher
    ..the transcriptions of stress response genes P53, growth arrest and DNA damage-inducible 45 alpha (Gadd45α), and COX1, suggested that TDF might cause oxidative stress during larvae development...
  18. Song G, Nesil T, Cao J, Yang Z, Chang S, Li M. Nicotine mediates expression of genes related to antioxidant capacity and oxidative stress response in HIV-1 transgenic rat brain. J Neurovirol. 2016;22:114-24 pubmed publisher
    ..Further, we found a significant downregulation of Gstm5 in the NAc and upregulation of Cox1, Cox3, and Gsta6 in the VTA of HIV-1Tg rats...
  19. Wang J, Lu L, Wang Y, Wu Y, Han J, Wang W, et al. Qishenyiqi Dropping Pill attenuates myocardial fibrosis in rats by inhibiting RAAS-mediated arachidonic acid inflammation. J Ethnopharmacol. 2015;176:375-84 pubmed publisher
    ..Expressions of phospholipase A2 (PLA2), cyclooxygenase 1 (COX1) and COX2 were also down-regulated in the QSDP-treated group...
  20. Amzati G, Pelle R, Muhigwa J, Kanduma E, Djikeng A, Madder M, et al. Mitochondrial phylogeography and population structure of the cattle tick Rhipicephalus appendiculatus in the African Great Lakes region. Parasit Vectors. 2018;11:329 pubmed publisher
    ..Sequencing was performed on two mitochondrial genes (cox1 and 12S rRNA) of 218 ticks collected from cattle across six AEZs along an altitudinal gradient in the Democratic ..
  21. Shariatzadeh S, Spotin A, Gholami S, Fallah E, Hazratian T, Mahami Oskouei M, et al. The first morphometric and phylogenetic perspective on molecular epidemiology of Echinococcus granulosus sensu lato in stray dogs in a hyperendemic Middle East focus, northwestern Iran. Parasit Vectors. 2015;8:409 pubmed publisher
    ..05). The phylogenetic analyses of cox1 sequences firmly revealed the 13 sheep strains (G1), one buffalo strain (G3), one camel strain (G6) and one mixed ..
  22. Schaefer S, Guerra B. Protein kinase CK2 regulates redox homeostasis through NF-?B and Bcl-xL in cardiomyoblasts. Mol Cell Biochem. 2017;436:137-150 pubmed publisher
    ..e., Fmo2, Ptgs1, Dhcr24, and Ptgs2...
  23. Waeschenbach A, Brabec J, Scholz T, Littlewood D, Kuchta R. The catholic taste of broad tapeworms - multiple routes to human infection. Int J Parasitol. 2017;47:831-843 pubmed publisher
    ..RNA subunits (ssrDNA, lsrDNA), large subunit mitochondrial ribosomal RNA (rrnL) and cytochrome c oxidase subunit I (cox1), we hypothesize that humans have been acquired asaccidental hosts four times across the tree of life of ..
  24. Dan A, Ronai Z, Széll Z, Sréter T. Prevalence and genetic characterization of Echinococcus spp. in cattle, sheep, and swine in Hungary. Parasitol Res. 2018;117:3019-3022 pubmed publisher
    ..The genetic diversity was evaluated by the DNA sequence analysis of the cytochrome c oxydase subunit 1 (cox1) mitochondrial gene. Echinococcus intermedius (n = 31), Echinococcus granulosus s.s...
  25. Ng H, Leo C, Parry L. Serelaxin (recombinant human relaxin-2) prevents high glucose-induced endothelial dysfunction by ameliorating prostacyclin production in the mouse aorta. Pharmacol Res. 2016;107:220-228 pubmed publisher
    ..Neither high glucose incubation nor serelaxin treatment had an effect on cyclooxygenase 1 and 2 (Ptgs1, Ptgs2), prostacyclin synthase (PTGIS) and receptor (Ptgir) as well as thromboxane A2 receptor (..
  26. Davaasuren A, Davaajav A, Ukhnaa B, Purvee A, Unurkhaan S, Luvsan A, et al. Neurocysticercosis: A case study of a Mongolian traveler who visited China and India with an updated review in Asia. Travel Med Infect Dis. 2017;20:31-36 pubmed publisher
    ..Serology showed strong positivity for NCC, and mitochondrial cox1 gene analysis revealed Indian but not Chinese haplotype of T. solium...
  27. Ramos B, González Acuña D, Loyola D, Johnson W, Parker P, Massaro M, et al. Landscape genomics: natural selection drives the evolution of mitogenome in penguins. BMC Genomics. 2018;19:53 pubmed publisher
    ..In contrast, COX1 had a signature of strong negative selection. ND4 Ka/Ks ratios were highly correlated with SST (Mantel, p-value: 0...
  28. Byun K, Kim D, Bayarsaikhan E, Oh J, Kim J, Kwak G, et al. Changes of calcium binding proteins, c-Fos and COX in hippocampal formation and cerebellum of Niemann-Pick, type C mouse. J Chem Neuroanat. 2013;52:1-8 pubmed publisher
    ..Taken together, reduction of these proteins may be one of the strong phenotypes related to the neuronal degeneration in NPC-/- mice. ..
  29. Huang Y, Tsai S, Thongchan D, Khatri Chhetri R, Wu H. Filarial nematode infection in eclectus parrots (Eclectus roratus) in Taiwan. Avian Pathol. 2017;46:188-194 pubmed publisher
    ..of nucleotide sequences from 18S ribosomal DNA gene (18S rDNA), mitochondrial cytochrome c oxidase subunit 1 (COX1) gene, and internal transcribed spacers 1-5.8S ribosomal DNA gene (ITS 1-5.8S rDNA)...
  30. Antunes Murata F, Cerqueira Cézar C, Thompson P, Tiwari K, Mowery J, Verma S, et al. Sarcocystis cymruensis: discovery in Western Hemisphere in the Brown rat (Rattus norvegicus) from Grenada, West Indies: redescription, molecular characterization, and transmission to IFN-? gene knockout mice via sporocysts from experimentally infecte. Parasitol Res. 2018;117:1195-1204 pubmed publisher
    ..Molecular characterization of sarcocysts 18S rDNA and 28S rDNA, ITS-1, and cox1 loci showed the highest similarity with S. rodentifelis and S. muris...
  31. Scott B, Hasstedt S, Bovill E, Callas P, Valliere J, Wang L, et al. Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. Blood Coagul Fibrinolysis. 2002;13:519-31 pubmed
    ..Cyclooxygenase-1 [prostaglandin H synthase 1 gene (PTGS1)] was tested as a plausible candidate for the unknown gene because of its role in primary hemostasis...
  32. Smith O, Jabbour H, Critchley H. Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation. Hum Reprod. 2007;22:1450-6 pubmed
    ..These data identify the E series prostaglandin receptors and their signalling pathways as potential therapeutic targets in the treatment of heavy menstruation. ..
  33. Varcasia A, Tamponi C, Tosciri G, Pipia A, Dore F, Schuster R, et al. Is the red fox (Vulpes vulpes) a competent definitive host for Taenia multiceps?. Parasit Vectors. 2015;8:491 pubmed publisher
    ..multiceps; nucleotide amplification and sequencing of mitochondrial genes (i.e., cox1 and Nd1) from the metacestode material confirmed the identification...
  34. Gjerde B, Giacomelli S, Bianchi A, Bertoletti I, Mondani H, Gibelli L. Morphological and molecular characterization of four Sarcocystis spp., including Sarcocystis linearis n. sp., from roe deer (Capreolus capreolus) in Italy. Parasitol Res. 2017;116:1317-1338 pubmed publisher
    ..polymerase chain reaction (PCR) amplification and sequencing of the partial cytochrome c oxidase subunit I gene (cox1) of all isolates, as well as PCR amplification, cloning and sequencing of the complete18S ribosomal RNA (rRNA) gene ..
  35. Silva M, Oliveira Cavalcante P, Camargo A, Chagas Moutinho V, Santos E, Santos C. Integrative taxonomy of Goezia spinulosa (Nematoda: Raphidascarididae) from arapaimas in the northwestern Brazil. Vet Parasitol. 2017;242:14-21 pubmed publisher
    ..New sequences for partial 18S rDNA, ITS1, 5.8S and ITS2 rDNA, partial 28S rDNA, cox1 mtDNA and for cox2 mtDNA are presented...
  36. Choudhary K, Tripathi A, Pandey K, Agrawal N. Morphological and molecular characterisation of three Indian Neascus-type metacercariae (Digenea: Diplostomidae). Parasitol Int. 2017;66:652-659 pubmed publisher
    ..Next, we characterised these metacecariae using nuclear (28S and ITS1) and mitochondrial DNA (cox1) to determine their systematic and phylogenetic position...
  37. Yang D, Zhao W, Zhang Y, Liu A. Prevalence of Hymenolepis nana and H. diminuta from Brown Rats (Rattus norvegicus) in Heilongjiang Province, China. Korean J Parasitol. 2017;55:351-355 pubmed publisher
    ..microscopy and genetic analysis by PCR amplification of the mitochondrial cytochrome c oxidase subunit 1 (COX1) gene and the internal transcribed spacer 2 (ITS2) region of the nuclear ribosomal RNA gene. In total, 6...
  38. Wu Y, Li L, Zhu G, Li W, Zhang N, Li S, et al. Mitochondrial genome data confirm that yaks can serve as the intermediate host of Echinococcus canadensis (G10) on the Tibetan Plateau. Parasit Vectors. 2018;11:166 pubmed publisher
    ..Full-length mitochondrial (mt) cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes were amplified by PCR...
  39. Yokoyama C, Tanabe T. Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem Biophys Res Commun. 1989;165:888-94 pubmed
    ..Human prostaglandin endoperoxide synthase exhibited 91% amino acid identity with the sheep enzyme. ..
  40. Haakensen V, Bjøro T, Lüders T, Riis M, Bukholm I, Kristensen V, et al. Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas. BMC Cancer. 2011;11:332 pubmed publisher
    ..Six genes (SCGB3A1, RSPO1, TLN2, SLITRK4, DCLK1, PTGS1) were found differentially expressed according to serum estradiol levels (FDR = 0)...
  41. Coskun I, Colkesen Y, Ayik F, Berdeli A, Atay Y. Novel non-synonymous polymorphisms in the COX-1 gene in Turkish pediatric patients with cardiovascular anomalies. Genet Mol Res. 2014;13:262-8 pubmed publisher
    ..These findings demonstrated novel genetic variants of the human COX- 1 gene. Future studies characterizing the functional impact of these variants are warranted. ..
  42. Kruszewski J, Golik P. Pentatricopeptide Motifs in the N-Terminal Extension Domain of Yeast Mitochondrial RNA Polymerase Rpo41p Are Not Essential for Its Function. Biochemistry (Mosc). 2016;81:1101-1110 pubmed
    ..Steady-state levels of COX1 and COX2 mRNAs are also moderately affected...
  43. Stoyanov B, Georgieva S, Pankov P, Kudlai O, Kostadinova A, Georgiev B. Morphology and molecules reveal the alien Posthodiplostomum centrarchi Hoffman, 1958 as the third species of Posthodiplostomum Dubois, 1936 (Digenea: Diplostomidae) in Europe. Syst Parasitol. 2017;94:1-20 pubmed publisher
    ..Gasterosteiformes: Gasterosteidae), Bulgaria (morphology, cox1 and ITS1-5.8S-ITS2) and Perca fluviatilis L. (Perciformes: Percidae), Czech Republic (morphology, cox1, ITS1-5...
  44. Rodrigues M, Morelli K, Jansen A. Cytochrome c oxidase subunit 1 gene as a DNA barcode for discriminating Trypanosoma cruzi DTUs and closely related species. Parasit Vectors. 2017;10:488 pubmed publisher
    The DNA barcoding system using the cytochrome c oxidase subunit 1 mitochondrial gene (cox1 or COI) is highly efficient for discriminating vertebrate and invertebrate species...
  45. Bjarnason I, Scarpignato C, Holmgren E, Olszewski M, Rainsford K, Lanas A. Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology. 2018;154:500-514 pubmed publisher
    ..Although mechanisms of damage involve the activities of prostaglandin-endoperoxide synthase 1 (PTGS1 or cyclooxygenase [COX] 1) and PTGS1 (COX2), other factors are involved...
  46. Hla T. Molecular characterization of the 5.2 KB isoform of the human cyclooxygenase-1 transcript. Prostaglandins. 1996;51:81-5 pubmed
  47. Asting A, Farivar A, Iresjö B, Svensson H, Gustavsson B, Lundholm K. EGF receptor and COX-1/COX-2 enzyme proteins as related to corresponding mRNAs in human per-operative biopsies of colorectal cancer. BMC Cancer. 2013;13:511 pubmed publisher
    ..Our present results are compatible with the theory that COX-2 and EGFR signalling pathways are inversely related in colorectal cancer tissue. This may explain why combinatorial clinical treatments have been less rewarding. ..
  48. Marková S, Filipi K, Searle J, Kotlík P. Mapping 3' transcript ends in the bank vole (Clethrionomys glareolus) mitochondrial genome with RNA-Seq. BMC Genomics. 2015;16:870 pubmed publisher
    ..TAA stop codons of four bank vole protein-coding genes (nad1, atp6, cox3 and nad4) are incompletely encoded in the DNA and are completed by polyadenylation...
  49. Santo Domingo J, Chareyron I, Broenimann C, Lassueur S, Wiederkehr A. Antibiotics induce mitonuclear protein imbalance but fail to inhibit respiration and nutrient activation in pancreatic ?-cells. Exp Cell Res. 2017;357:170-180 pubmed publisher
    ..efficiently reduced mitochondrial protein synthesis in INS-1E cells, lowering expression of the mtDNA encoded COX1 subunit of the respiratory chain but not the nuclear encoded ATP-synthase subunit ATP5A...
  50. Kirillova V, Prakas P, Calero Bernal R, Gavarāne I, Fernández García J, Martínez González M, et al. Identification and genetic characterization of Sarcocystis arctica and Sarcocystis lutrae in red foxes (Vulpes vulpes) from Baltic States and Spain. Parasit Vectors. 2018;11:173 pubmed publisher
    ..Based on LM, TEM, 18S rDNA, 28S rDNA, ITS1, cox1 and rpoB sequences, Sarcocystis arctica and Sarcocystis lutrae cysts were identified in red fox muscles from Latvia ..
  51. Vane J, Mitchell J, Appleton I, Tomlinson A, Bishop Bailey D, Croxtall J, et al. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci U S A. 1994;91:2046-50 pubmed
    ..Thus, there may be differential regulation of these enzymes, perhaps due to the changing pattern of cytokines during the inflammatory response. ..
  52. Arisawa T, Hirata I. [Genetic polymorphism of COX-1 gene and NSAID-induced ulcer]. Nihon Rinsho. 2007;65:1885-9 pubmed
    ..In conclusions, the assessment for genotype of COX-1 gene promoter polymorphism, especially rs1330344, may be useful for detecting the high risk group of developing NSAID-induced ulcer diseases. ..
  53. Cao L, Zhang Z, Sun W, Bai W, Sun W, Zhang Y, et al. Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin. Gene. 2014;546:172-6 pubmed publisher
    ..In conclusion, in Chinese patients with ischemic stroke and treated with aspirin, CC genotype of rs1330344 may increase the risk of subsequent vascular events. ..
  54. Lopez Jimenez A, Pérez Ponce de León G, García Varela M. Molecular data reveal high diversity of Uvulifer (Trematoda: Diplostomidae) in Middle America, with the description of a new species. J Helminthol. 2018;92:725-739 pubmed publisher
    ..8S nuclear genes, as well as the internal transcribed spacers ITS1 and ITS2, and one mitochondrial gene (cox1)...
  55. Bingham S, Beswick P, Blum D, Gray N, Chessell I. The role of the cylooxygenase pathway in nociception and pain. Semin Cell Dev Biol. 2006;17:544-54 pubmed
    ..This review covers factors influencing COX enzyme activity, the role of their products in the development and maintenance of pain and discusses recent safety concerns of COX-2 inhibitors. ..
  56. Brant S, Jouet D, Ferté H, Loker E. Anserobilharzia gen. n. (Digenea, Schistosomatidae) and redescription of A. brantae (Farr & Blankemeyer, 1956) comb. n. (syn. Trichobilharzia brantae), a parasite of geese (Anseriformes). Zootaxa. 2013;3670:193-206 pubmed
    ..Using nuclear 28S, ITS and mitochondrial cox1 as genetic yardsticks, samples of A...
  57. Zhou C, Ouyang S, Wu X, Ding M. The complete maternal mitochondrial genome of rare Chinese freshwater mussel Lepidodesma languilati (Bivalvia: Unionidae: Unioninae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:4615-4616 pubmed
    ..1%), T (25.7%), C (23.4%), and G (11.8%). Except for cox1 (TTG), cob (ATT), nad1 (ATT), nad6 (ATA), nad4 (TTG), and atp8 (GTG), 7 of the 13 protein-coding genes initiate ..
  58. Liao K, Yan J, Mai K, Ai Q. Dietary lipid concentration affects liver mitochondrial DNA copy number, gene expression and DNA methylation in large yellow croaker (Larimichthys crocea). Comp Biochem Physiol B Biochem Mol Biol. 2016;193:25-32 pubmed publisher
    ..The transcription of cytochrome c oxidase 1 (COX1), COX2, COX3, ATP synthase 6 (ATPase 6), 12S rRNA and 16S rRNA was also significantly increased in the low-lipid ..
  59. Liu Q, Chai X, Jiang S, Zhou C, Xuan F, Zhang D, et al. Identification of the complete mitochondrial genome of the pacific white shrimp Litopenaeus vannamei (Decapoda: Penaeidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:4693-4695 pubmed
    ..Thirteen PCGs were initiated by ATN codons, except for cox1 gene which was initiated by ACG. Four of the 13 PCGs had the incomplete termination codon by T...
  60. Olivieri E, Zanzani S, Latrofa M, Lia R, Dantas Torres F, Otranto D, et al. The southernmost foci of Dermacentor reticulatus in Italy and associated Babesia canis infection in dogs. Parasit Vectors. 2016;9:213 pubmed publisher
    ..were molecularly characterised by the amplification and sequencing of partial mitochondrial 12S rRNA, 16S rRNA and cox1 genes...
  61. Badri A, Stefani F, Lachance G, Roy Arcand L, Beaudet D, Vialle A, et al. Molecular diagnostic toolkit for Rhizophagus irregularis isolate DAOM-197198 using quantitative PCR assay targeting the mitochondrial genome. Mycorrhiza. 2016;26:721-33 pubmed publisher
    ..of 14 complete AMF mitochondrial (mt) genomes, a qPCR assay using a hydrolysis probe designed in the single copy cox3-rnl intergenic region was tested and validated to specifically and accurately quantify the spores of R...
  62. Das S, KOHR M, Dunkerly Eyring B, Lee D, Bedja D, Kent O, et al. Divergent Effects of miR-181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets. J Am Heart Assoc. 2017;6: pubmed publisher
    ..in infarct size in miR-181a/b-/- mice due to increased PTEN signaling, whereas miR-181c targets mt-COX1 in the mitochondria, resulting in decreased infarct size in miR-181c/d-/- mice...
  63. Wu F, Kumagai L, Cen Y, Chen J, Wallis C, Polek M, et al. Analyses of Mitogenome Sequences Revealed that Asian Citrus Psyllids (Diaphorina citri) from California Were Related to Those from Florida. Sci Rep. 2017;7:10154 pubmed publisher
    ..Further analyses were performed on sequences in cox1 and trnAsn regions with 100 ACPs, SNPs in nad1-nad4-nad5 locus through PCR with 252 ACP samples...
  64. Kalyanasundaram A, Blanchard K, Henry C, Brym M, Kendall R. Development of a multiplex quantitative PCR assay for eyeworm (Oxyspirura petrowi) and caecal worm (Aulonocephalus pennula) detection in Northern bobwhite quail (Colinus virginianus) of the Rolling Plains Ecoregion, Texas. Vet Parasitol. 2018;253:65-70 pubmed publisher
    ..was developed in this study to detect eyeworm and caecal worm infection through egg detection using the ITS2 and COX1 gene region, respectively...
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    ..On the basis of present experiments we conclude that gp-120-induced release of PGE2 by astroglial cells is driven by NO, thereby contributing in the involvement of glial cells in HIV-related cerebral disorders. ..
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    ..1 +/- 2.0 years) (mean +/- standard deviation), we determined the frequency of polymorphisms in cyclooxygenase 1 (COX1) (A-842G and C50T), glycoprotein IIIa (GPIIIa) (PLA1/A2) and purinergic receptor P2Y (P2Y1) (C893T and ..
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    ..The KM for the enzyme remained the same as COX-1. However, the V(max) of the COX-1 mutant decreased by 3.3-fold. We conclude that the COX-1 specific amino-terminal sequence has a subtle but detectable effect on COX-1 catalysis. ..
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    ..basis of the concatenated sequence of mitochondrial NADH dehydrogenase subunit 1 (nad1) and cytochrome c oxidase 1 (cox1). The index of neutrality (Fu's Fs) suggests rapid expansion of the Nigerian F. gigantica population...
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    ..DNA was extracted from cyst material, and polymerase chain reactions (PCR) were performed targeting cox1 and nad1 genes. Amplicons were sequenced directly and the resulting sequences were aligned and analysed...
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    ..specific PTGS2 inhibitors, as adjuvant drugs in CRC are (1) a frequent confusion about the physiological role of PTGS1 and PTGS2, reflecting in CRC pathology and therapy; (2) the presence of unavoidable side effects linked to the ..
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    ..Cyclooxygenase regulates colon carcinoma-induced angiogenesis by two mechanisms: COX-2 can modulate production of angiogenic factors by colon cancer cells, while COX-1 regulates angiogenesis in endothelial cells. ..
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    ..In addition, the process may be initiated by cytoplasmic ERalpha, and critical receptor elements reside within the amino terminus. ..
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    ..A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain)...
  76. Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, et al. Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population. Hepatogastroenterology. 2008;55:987-90 pubmed
    ..This study attempted to clarify the relationship between cyclooxygenase-1 (COX1) gene polymorphisms (T-1676C and A-842G/C50T) and ulcerative colitis in a Japanese population...
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    ..24%, P=0.082). A 600 mg loading dose of clopidogrel failed to acceptably inhibit platelet reactivity in patients who were positive for the PlA2 polymorphism. ..
  78. Hahn T, Heinzel S, Plichta M, Reif A, Lesch K, Fallgatter A. Neurovascular coupling in the human visual cortex is modulated by cyclooxygenase-1 (COX-1) gene variant. Cereb Cortex. 2011;21:1659-66 pubmed publisher
    ..Additionally, our results may have important implications for functional brain imaging in which HRs are commonly used as a surrogate for neural activation. ..
  79. Karamian M, Haghighi F, Hemmati M, Taylor W, Salehabadi A, Ghatee M. Heterogenity of Echinococcus canadensis genotype 6 - the main causative agent of cystic echinococcosis in Birjand, Eastern Iran. Vet Parasitol. 2017;245:78-85 pubmed publisher
    ..and their life cycles in eastern Iran. We analysed the partial sequences of the nad1 and cox1 genes from 17 isolates from hydatid cyst-infected patients (n=9), camels (n=5) and sheep (n=3) in Birjand, eastern ..
  80. García Varela M, Mendoza Garfias B, Choudhury A, Pérez Ponce de León G. Morphological and molecular data for a new species of Pomphorhynchus Monticelli, 1905 (Acanthocephala: Pomphorhynchidae) in the Mexican redhorse Moxostoma austrinum Bean (Cypriniformes: Catostomidae) in central Mexico. Syst Parasitol. 2017;94:989-1006 pubmed publisher
    ..Sequences of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene and the large subunit (LSU) rDNA (including the domains D2-D3) were used to corroborate the morphological ..
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    ..Each PCG was initiated by an authoritative ATN codon, except for COX1 initiated by a GTG codon...
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    ..Ser-530 also influences the substrate specificity of PGHS-1; an S530T substitution causes 40- and 750-fold decreases in oxygenation efficiencies for AA and DHLA, respectively. ..
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    ..It remains to be investigated whether treatment with selective inhibitors of COX-2 may be an additional therapeutic option for patients with breast carcinoma. ..
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    ..22TT genotype confers a small protective effect against atopy. Potential associations with aspirin-intolerant asthma were identified and warrant further investigation in a larger population of aspirin-intolerant asthma patients. ..
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    ..45, P<0.001) in the placental tissue of women with pre-eclampsia. These results suggest that COX-1 and COX-2 activities are decreased in the placental tissue of women with pre-eclampsia, probably by oxidative stress. ..
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    ..These findings may help in reassessing the optimal antiplatelet strategy in ET. ..
  89. Yanagida T, Lavikainen A, Hoberg E, Konyaev S, Ito A, Sato M, et al. Specific status of Echinococcus canadensis (Cestoda: Taeniidae) inferred from nuclear and mitochondrial gene sequences. Int J Parasitol. 2017;47:971-979 pubmed publisher
    ..Nucleotide sequences of complete mitochondrial cytochrome c oxidase subunit 1 (cox1) and partial nuclear phosphoenolpyruvate carboxykinase (pepck) and DNA polymerase delta (pold) were determined for ..
  90. Gjerde B, Luzón M, Alunda J, de la Fuente C. Morphological and molecular characteristics of six Sarcocystis spp. from red deer (Cervus elaphus) in Spain, including Sarcocystis cervicanis and three new species. Parasitol Res. 2017;116:2795-2811 pubmed publisher
    ..molecularly through PCR amplification and sequencing of the partial cytochrome c oxidase subunit I gene (cox1) of the mitochondrial genome, revealing the presence of six major cox1 sequence types...
  91. Carnevale S, Malandrini J, Pantano M, Soria C, Rodrigues Silva R, Machado Silva J, et al. First genetic characterization of Fasciola hepatica in Argentina by nuclear and mitochondrial gene markers. Vet Parasitol. 2017;245:34-38 pubmed publisher
    ..dinucleotide dehydrogenase subunits 4 and 5 (nad4 and nad5) and mitochondrial cytochrome c oxidase subunit I (cox1) genes as genetic markers. Phylogenies were reconstructed using maximum parsimony algorithm...
  92. Huang N, Wang C, Zhang N, Mao W, Liu B, Shen Y, et al. Effect of estrogen on prostaglandin synthetase in bovine oviduct smooth muscle. Eur J Pharmacol. 2018;818:287-293 pubmed publisher
    ..Our objective was to study the regulation of prostaglandin synthetase (prostaglandin-endoperoxide synthase-1 (PTGS1), prostaglandin-endoperoxide synthase-2 (PTGS2), mPGES-1, mPGES-2, cPGES, and PGFS) by estradiol (E2) ..