Gene Symbol: PTGFR
Description: prostaglandin F receptor
Alias: prostaglandin F2-alpha receptor, FP prostanoid receptor, PGF receptor, PGF2 alpha receptor, prostaglandin receptor (2-alpha), prostanoid FP receptor
Species: human
Products:     PTGFR

Top Publications

  1. Peng H, Zahary M, Tajudin L, Lin C, Teck C, Sidek M, et al. A novel single nucleotide polymorphism, IVS2 -97A>T, in the prostaglandin F2alpha receptor gene was identified among the Malaysian patients with glaucoma. Kobe J Med Sci. 2007;53:49-52 pubmed
    ..2% homozygous. The frequency of variant allele T was 0.28. Although with a limited number of samples, our data suggested that this polymorphism is common in the Malaysian patients with glaucoma. ..
  2. Sales K, Milne S, Williams A, Anderson R, Jabbour H. Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways. J Clin Endocrinol Metab. 2004;89:986-93 pubmed
    ..These data suggest that PGF(2 alpha)-FP receptor promote endometrial tumorigenesis via a phospholipase C-mediated phosphorylation of the EGFR and MAPK signaling pathways. ..
  3. Vielhauer G, Fujino H, Regan J. Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. Arch Biochem Biophys. 2004;421:175-85 pubmed
    ..hFPs represents the first confirmed alternative splice variant of the human FP prostanoid receptor gene, however, its function is presently unknown.
  4. Sales K, Boddy S, Williams A, Anderson R, Jabbour H. F-prostanoid receptor regulation of fibroblast growth factor 2 signaling in endometrial adenocarcinoma cells. Endocrinology. 2007;148:3635-44 pubmed
  5. Abramovitz M, Boie Y, Nguyen T, Rushmore T, Bayne M, Metters K, et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem. 1994;269:2632-6 pubmed
    A cDNA clone coding for a functional human prostanoid FP receptor has been isolated from a uterus cDNA library...
  6. Sales K, Grant V, Jabbour H. Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element. Mol Cell Endocrinol. 2008;285:51-61 pubmed publisher
    ..These data indicate that PGE(2) and PGF(2alpha) biosynthesized locally within endometrial adenocarcinomas can regulate tumor cell function in an autocrine/paracrine manner via the FP receptor. ..
  7. Pareek C, Sachajko M, Jaskowski J, Herudzinska M, Skowronski M, Domagalski K, et al. Comparative Analysis of the Liver Transcriptome among Cattle Breeds Using RNA-seq. Vet Sci. 2019;6: pubmed publisher
  8. Alarcón R, Varayoud J, Luque E, Milesi M. Effect of neonatal exposure to endosulfan on myometrial adaptation during early pregnancy and labor in rats. Mol Cell Endocrinol. 2019;: pubmed publisher
    ..expression of contraction-associated genes (oxytocin receptor, OTXR; prostaglandin F2α receptor, PTGFR and connexin-43, Cx-43)...
  9. Baryla M, Kaczynski P, Goryszewska E, Riley S, Waclawik A. Prostaglandin F2α stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo. Placenta. 2019;77:19-29 pubmed publisher
    ..Doses of 100 nM and/or 1 μM of PGF and fluprostenol were used. PGF receptor (PTGFR), MMP9 and MMP2 proteins in the human first trimester placenta were localized by immunohistochemistry and ..

More Information

Publications101 found, 100 shown here

  1. Li W, Zhou Q, Gao Y, Jiang Y, Huang Y, Mo Z, et al. eQTL analysis from co-localization of 2739 GWAS loci detects associated genes across 14 human cancers. J Theor Biol. 2018;462:240-246 pubmed publisher
    ..Associations between the 18 cis-regulatory genes and the pathologic stage of each cancer showed that MYL2 and PTGFR in HNSC, 4 genes (F8, SATB2, G6PD and UGT1A6) in KIRP, 3 genes (CHMP4C, MAP3K1 and MECP2) in LUAD were all ..
  2. Lee Thacker S, Choi Y, Taniuchi I, Takarada T, Yoneda Y, Ko C, et al. Core Binding Factor β Expression in Ovarian Granulosa Cells Is Essential for Female Fertility. Endocrinology. 2018;159:2094-2109 pubmed publisher
    ..and corpora lutea of these mice, the expression of Edn2, Ptgs1, Lhcgr, Sfrp4, Wnt4, Ccrl2, Lipg, Saa3, and Ptgfr was also drastically reduced...
  3. Wu W, Xu Y, Cheng W, Yuan B, Zhao J, Wang Y, et al. Decreased PGF may contribute to trophoblast dysfunction in fetal growth restriction. Reproduction. 2017;154:319-329 pubmed publisher
    ..Trophoblastic cell lines were treated with ZM-306416, an inhibitor of PGF receptor FLT1, to observe the effect of PGF/FLT1 signaling on cell proliferation and migration...
  4. Lim R, Barker G, Lappas M. IRF5 is increased in labouring myometrium and regulates pro-labour mediators. Reproduction. 2018;156:207-218 pubmed publisher
    ..adhesion molecules (ICAM1, VCAM1) and contraction-associated proteins PTGS2, PGF and PTGFR when in the presence of IL1B, TNF, fsl-1 (TLR2/6 ligand) or flagellin (TLR5 ligand)...
  5. Sinreih M, Anko M, Kene N, Kocbek V, Rižner T. Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2α biosynthesis and action in ovarian endometriosis tissue and in model cell lines. Chem Biol Interact. 2015;234:320-31 pubmed publisher
    ..Among genes involved in PGF2α biosynthesis, metabolism and action PLA2G2A, PTGS2/COX-2, ABCC4 and PTGFR were up-regulated, mRNA levels of SLCO2A, PTGDS and HPGDS were unchanged, and genes PLA2G4A and HPGD were down-..
  6. Gao L, Gao R, Mao W, Liu B, Zhang S, Tahala D, et al. PTGFR activation promotes the expression of PTGS-2 and growth factors via activation of the PKC signaling pathway in bovine endometrial epithelial cells. Anim Reprod Sci. 2018;199:30-39 pubmed publisher
    ..In the present study, it was investigated whether prostaglandin F receptor (PTGFR) activation could induce expression of prostaglandin-endoperoxide synthase 2 (PTGS-2) and growth factors ..
  7. Wijesuriya Y, Lappas M. Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium. Phytomedicine. 2018;49:11-22 pubmed publisher
    ..Moreover, in myometrium, honokiol significantly suppressed the expression of the contraction associated protein PTGFR, the secretion of the uterotonic prostaglandins PGE2 and PGF2α, and blocked TNF-induced ..
  8. Ucar E, Cetin H, Atli M. Effect of multiple low-dose PGF2α injections on the mature corpus luteum in non-pregnant bitches. Theriogenology. 2018;113:34-43 pubmed publisher
    ..FASLG increased only after the third PGF2α injection. The mRNA levels of PTGFR, PGT, and PTGS2 decreased as the number of PGF2α injections increased...
  9. Korber H, Goericke Pesch S. Expression of PTGS2, PGFS and PTGFR during downregulation and restart of spermatogenesis following GnRH agonist treatment in the dog. Cell Tissue Res. 2019;375:531-541 pubmed publisher
    ..PTGS2, prostaglandin F synthase (PGFS) and PGF receptor (PTGFR) are investigated in the adult male dog using the model of the GnRH-agonist implant downregulated canine ..
  10. Lim R, Barker G, Lappas M. Pellino 1 is a novel regulator of TNF and TLR signalling in human myometrial and amnion cells. J Reprod Immunol. 2018;127:24-35 pubmed publisher
    ..In siPELI1 transfected myometrial cells, there was a decrease in prostaglandin PGF2? and its receptor, PTGFR mRNA expression when treated with TNF...
  11. Piasecka Srader J, Blanco F, Delman D, Dixon D, Geiser J, Ciereszko R, et al. Tamoxifen prevents apoptosis and follicle loss from cyclophosphamide in cultured rat ovaries. Biol Reprod. 2015;92:132 pubmed publisher inflammation, including mediators of lipoxygenase and prostaglandin production and signaling (Alox5, Pla2g1b, Ptgfr), cytokine binding (Il1r1, Il2rg ), apoptosis (Tnfrsf1a), second messenger signaling (Mapk1, Mapk14, Plcg1), as ..
  12. Fukuda M, Aoki T, Manabe T, Maekawa A, Shirakawa T, Kataoka H, et al. Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872. J Pharmacol Sci. 2014;126:230-42 pubmed
  13. Lüttgenau J, Möller B, Kradolfer D, Wellnitz O, Bruckmaier R, Miyamoto A, et al. Lipopolysaccharide enhances apoptosis of corpus luteum in isolated perfused bovine ovaries in vitro. Reproduction. 2016;151:17-28 pubmed publisher
    ..angiogenic (VEGFA121, FGF2), and vasoactive (EDN1) factors; and factors of prostaglandin synthesis (PGES, PGFS, PTGFR) and apoptosis (CASP3, -8, -9). Treatment with LPS abolished the hCG-induced increase in P4 (P≤0...
  14. Chang J, Frandsen S, D Annibale Tolhurst M, Palumbo N, Gadsby J. Prostaglandin (PTG) E and F receptors in the porcine corpus luteum; effect of tumor necrosis factor-?. Anim Reprod Sci. 2018;: pubmed publisher
    ..In Experiment 2, the data obtained showed that TNF-? decreased PTGER-3/EP-3 and increased PTGFR/FP protein (in EARLY stage CL)...
  15. Tian X, Anthony K, Diaz F. Transition Metal Chelator Induces Progesterone Production in Mouse Cumulus-Oocyte Complexes and Corpora Lutea. Biol Trace Elem Res. 2017;176:374-383 pubmed publisher
    ..Feeding a zinc-deficient diet for 10 days, but not 3 days, increased Star, Hsd3b, and prostaglandin F2 alpha receptor (Ptgfr) mRNA ~2.5-fold, suggesting that the effect of TPEN is through modulation of zinc availability...
  16. Liong S, Lim R, Barker G, Lappas M. Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro-labour mediators OA. Am J Reprod Immunol. 2017;78: pubmed publisher
    ..of chemokines CXCL8 and CCL2; the expression and secretion of adhesion molecules ICAM1 and VCAM1; and PTGS2 and PTGFR mRNA expression and the release of prostaglandin PGF2α ...
  17. Lappas M. A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes. Mol Hum Reprod. 2017;23:628-645 pubmed publisher
    ..IL6), chemokines (CXCL1, CXCL8, CCL2), adhesion molecules (ICAM1, VCAM1), contraction-associated proteins (PTGS2, PTGFR, PGF2?) and the extracellular matrix degrading enzyme MMP9, as well as NF-?B activation...
  18. Yamagishi Kimura R, Honjo M, Aihara M. Contribution of prostanoid FP receptor and prostaglandins in transient inflammatory ocular hypertension. Sci Rep. 2018;8:11098 pubmed publisher
    ..This OH was significantly diminished by nepafenac treatment in FPKO mice, suggesting that FP receptor may have an important naïve physiological role in the eye, and could regulate IOP elevation during PG-associated ocular inflammation. ..
  19. Lüttgenau J, Lingemann B, Wellnitz O, Hankele A, Schmicke M, Ulbrich S, et al. Repeated intrauterine infusions of lipopolysaccharide alter gene expression and lifespan of the bovine corpus luteum. J Dairy Sci. 2016;99:6639-6653 pubmed publisher
    ..and the apoptosis-related factor CASP3 were higher, and those of steroidogenic factors STAR and HSD3B, the PGF receptor, and the angiogenic factor VEGFA121 were lower after LPS challenge compared with the control...
  20. Ziecik A, Przygrodzka E, Jalali B, Kaczmarek M. Regulation of the porcine corpus luteum during pregnancy. Reproduction. 2018;156:R57-R67 pubmed publisher
    ..luteolytic switch' involves increased expression of many regression mediators and activation of the post PTGFR signaling pathway...
  21. Peng L, Sun B, Liu M, Huang J, Liu Y, Xie Z, et al. Plasma metabolic profile reveals PGF2α protecting against non-proliferative diabetic retinopathy in patients with type 2 diabetes. Biochem Biophys Res Commun. 2018;496:1276-1283 pubmed publisher
    ..Our results suggested that PGF2α may be a protective factor in the progression of NPDR in T2D patients. The protective mechanism of PGF2α was to increase pericyte mobility through FP receptor/RhoA pathway. ..
  22. Kim S, Markosyan N, Pepe G, Duffy D. Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells. Reproduction. 2015;149:453-64 pubmed publisher
    ..A PTGFR agonist decreased progesterone production in luteal cells obtained at mid-late and late luteal phases, but did not ..
  23. Lappas M. Runt-related transcription factor 1 (RUNX1) deficiency attenuates inflammation-induced pro-inflammatory and pro-labour mediators in myometrium. Mol Cell Endocrinol. 2018;473:61-71 pubmed publisher
    ..expression of pro-inflammatory cytokines, chemokines, adhesion molecules, contraction-associated proteins OXR and PTGFR, the uterotonic PGF, and the ECM remodelling enzyme MMP9...
  24. Hu C, Liu B, Li H, Wu X, Guo T, Luo W, et al. Prostaglandin D2 evokes potent uterine contraction via the F prostanoid receptor in postpartum rats. Eur J Pharmacol. 2018;836:11-17 pubmed publisher
  25. Xu C, Liu W, You X, Leimert K, Popowycz K, Fang X, et al. PGF2α modulates the output of chemokines and pro-inflammatory cytokines in myometrial cells from term pregnant women through divergent signaling pathways. Mol Hum Reprod. 2015;21:603-14 pubmed publisher
    ..Since the PGF2α receptor (PTGFR) couples via the Gq protein and subsequently activates the phospholipase C (PLC) and protein kinase C (PKC) ..
  26. Zhang S, Liu B, Gao L, Mao W, Fu C, Duritahala D, et al. Prostaglandin F2?-PTGFR signalling activation, growth factor expression and cell proliferation in bovine endometrial explants. Reprod Fertil Dev. 2017;29:2195-2205 pubmed publisher
    ..and the responses of a series of growth factors essential for endometrial growth to PGF2? receptor (PTGFR) activation were investigated in bovine endometrial explants in vitro...
  27. Walusimbi S, Wetzel L, Townson D, Pate J. Isolation of luteal endothelial cells and functional interactions with T lymphocytes. Reproduction. 2017;153:519-533 pubmed publisher
    ..LEC expressed mRNA for progesterone receptor (PGR), prostaglandin receptors (PTGFR, PTGER2 and 4, and PTGIR), tumor necrosis factor receptors (TNFRSF1A&B) and interleukin (IL) 1B receptors (..
  28. Waite C, Mejia R, Ascoli M. Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation. Biol Reprod. 2016;94:62 pubmed publisher
    Parturition in rodents is highly dependent on the engagement of the luteal prostaglandin F2 alpha receptor, which, through activation of the Gq/11 family of G proteins, increases the expression of Akr1c18, leading to an increase in ..
  29. Kaczynski P, Kowalewski M, Waclawik A. Prostaglandin F2α promotes angiogenesis and embryo-maternal interactions during implantation. Reproduction. 2016;151:539-52 pubmed publisher
    ..that the conceptus and its signal (estradiol-17β) elevated endometrial expression of PGF2α receptor (PTGFR) in vivo and in vitro PTGFR protein was expressed mainly in luminal epithelial (LE) and glandular epithelial cells ..
  30. Kozai K, Tokuyama S, Szóstek A, Toishi Y, Tsunoda N, Taya K, et al. Evidence for a PGF2α auto-amplification system in the endometrium in mares. Reproduction. 2016;151:517-26 pubmed publisher
    ..05). PGF receptor (PTGFR) mRNA expression in the endometrium was significantly higher in the late luteal phase than in the early ..
  31. Liu X, Qian Z, Xie F, Fan W, Nelson J, Xiao X, et al. Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid. Prostaglandins Other Lipid Mediat. 2017;132:31-40 pubmed publisher
    ..of 14,15-EET, with the top five being prostaglandin receptor subtypes (PTGER2, PTGER4, PTGFR, PTGDR, PTGER3IV)...
  32. Paradis J, Ly S, Blondel Tepaz Ã, Galan J, Beautrait A, Scott M, et al. Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression. Proc Natl Acad Sci U S A. 2015;112:E5160-8 pubmed publisher
  33. Xiong Y, Chen H, Lin P, Wang A, Wang L, Jin Y. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. Am J Physiol Cell Physiol. 2017;312:C341-C353 pubmed publisher
    ..i>prostaglandin-endoperoxide synthase 2 (Ptgs2), and prostaglandin F receptor (Ptgfr) expression in mouse granulosa cells, which are proteins crucial for follicular development...
  34. Lim R, Barker G, Lappas M. PARK7 regulates inflammation-induced pro-labour mediators in myometrial and amnion cells. Reproduction. 2018;155:207-218 pubmed publisher
    ..cytokine IL6, chemokines (CXCL8, CCL2), adhesion molecule ICAM1, prostaglandin PGF and its receptor PTGFR. Similarly, amnion cells transfected with siPARK7 displayed a decrease in IL1B-induced expression of IL6, CXCL8 ..
  35. Przygrodzka E, Kaczmarek M, Kaczynski P, Ziecik A. Steroid hormones, prostanoids, and angiogenic systems during rescue of the corpus luteum in pigs. Reproduction. 2016;151:135-47 pubmed publisher
    ..cycle (CYP19A1, ESR2, PTGS2, HIF1A, and EDN1) and on days 12-14 of pregnancy (SCARB1, PGRMC1, STAR, HSD3B1, NR5A1, PTGFR, PTGER4, and VEGFA)...
  36. Grzesiak M, Knapczyk Stwora K, Slomczynska M. The impact of flutamide on prostaglandin F2α synthase and prostaglandin F2α receptor expression, and prostaglandin F2α concentration in the porcine corpus luteum of pregnancy. Domest Anim Endocrinol. 2017;59:81-89 pubmed publisher
    ..The present study investigated the impact of flutamide on luteal PGFS and PTGFR expression, as well as intraluteal PGF2α content during pregnancy in pigs...
  37. Wahid H, Dorian C, Chin P, Hutchinson M, Rice K, Olson D, et al. Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice. Endocrinology. 2015;156:3828-41 pubmed publisher
    ..Because causal pathways for term and preterm labor converge with TLR4, interventions to manipulate TLR4 signaling may have therapeutic utility for women at risk of preterm labor, or in postterm pregnancy. ..
  38. Zhang P, Jiang B, Xie L, Huang W. PTGFR and SLCO2A1 Gene Polymorphisms Determine Intraocular Pressure Response to Latanoprost in Han Chinese Patients with Glaucoma. Curr Eye Res. 2016;41:1561-1565 pubmed
    To determine the relationship between the polymorphisms of the prostaglandin F2α receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and response to latanoprost treatment in Han Chinese patients with ..
  39. Lüttgenau J, Wellnitz O, Kradolfer D, Kalaitzakis E, Ulbrich S, Bruckmaier R, et al. Intramammary lipopolysaccharide infusion alters gene expression but does not induce lysis of the bovine corpus luteum. J Dairy Sci. 2016;99:4018-4031 pubmed publisher
    ..3, toll-like receptors (TLR2, -4), tumor necrosis factor α (TNFA), and prostaglandin-related factors (PGES, PGFS, PTGFR). Intramammary LPS infusion caused considerable inflammatory responses in the treated udder quarters...
  40. Juntti S, Hilliard A, Kent K, Kumar A, Nguyen A, Jimenez M, et al. A Neural Basis for Control of Cichlid Female Reproductive Behavior by Prostaglandin F2α. Curr Biol. 2016;26:943-9 pubmed publisher
    ..signal to mate and show that the gonadal steroid DHP modulates mRNA levels of the putative receptor for PGF2α (Ptgfr). We use CRISPR/Cas9 to generate the first targeted gene mutation in A...
  41. Lake S, Gullberg H, Wahlqvist J, Sjögren A, Kinhult A, Lind P, et al. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS Lett. 1994;355:317-25 pubmed
    ..Using [3H]PGF2 alpha, binding of PGs showed the rank order of fluprostenol > PhXA70 > PGF2 alpha > or = PhXA85 > PGD2 > PGE2. ..
  42. Kyveris A, Maruscak E, Senchyna M. Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. Mol Vis. 2002;8:51-8 pubmed
  43. Hébert R, Carmosino M, Saito O, Yang G, Jackson C, Qi Z, et al. Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct. J Biol Chem. 2005;280:35028-37 pubmed
    ..In contrast to the Ca(2+) signal transduced by other FP receptors, this renal FP receptor signals via a PT-sensitive mechanism that is not coupled to cell Ca(2+). ..
  44. Abera A, Sales K, Catalano R, Katz A, Jabbour H. EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway. Cell Signal. 2010;22:71-9 pubmed publisher
    ..In conclusion, this study demonstrates that co-activation of the FP and EP2 receptors results in enhanced release of cAMP via FP receptor-G alpha(q)-Ca(2+)-calmodulin pathway by activating calcium sensitive AC3 isoform. ..
  45. Guo C, Kasaraneni N, Sun K, Myatt L. Cross talk between PKC and CREB in the induction of COX-2 by PGF2? in human amnion fibroblasts. Endocrinology. 2012;153:4938-45 pubmed
    ..This feed-forward loop may be crucial for the production of prostaglandins in the fetal membranes prior to the onset of labor...
  46. Xiao B, Gu S, Li M, Li J, Tao B, Wang Y, et al. Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population. Arterioscler Thromb Vasc Biol. 2015;35:1687-95 pubmed publisher
    ..rs12731181 in the seed region of the miR-590-3p target site is associated with increased risk of essential hypertension and represents a new paradigm for FP involvement in blood pressure regulation. ..
  47. Cui X, Zhao A, Wang X. Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma. J Clin Pharm Ther. 2017;42:87-92 pubmed publisher aimed to explore possible correlations of common single nucleotide polymorphisms (SNPs) in AFAP1, GMDS and PTGFR genes with intra-ocular pressure (IOP) response to latanoprost in POAG patients...
  48. Bastien L, Sawyer N, Grygorczyk R, Metters K, Adam M. Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. J Biol Chem. 1994;269:11873-7 pubmed
    ..Northern blot analysis showed that hEP2 is expressed as a 3.8-kilobase mRNA in a number of human tissues with the highest expression levels present in the small intestine. ..
  49. Sugimoto Y, Yamasaki A, Segi E, Tsuboi K, Aze Y, Nishimura T, et al. Failure of parturition in mice lacking the prostaglandin F receptor. Science. 1997;277:681-3 pubmed
    ..These results indicate that parturition is initiated when prostaglandin F2alpha interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis. ..
  50. Kunapuli P, Lawson J, Rokach J, Fitzgerald G. Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. J Biol Chem. 1997;272:27147-54 pubmed
    ..Incidental receptor activation by isoprostanes may complement the actions of PGF2alpha in clinical syndromes where oxidant stress and augmented prostaglandin biosynthesis coincide. ..
  51. Neuschäfer Rube F, Engemaier E, Koch S, Böer U, Püschel G. Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J. 2003;371:443-9 pubmed
    ..PGF(2alpha)-induced inositol formation was strongly reduced in the mutant Asp-300Gln, inferring a role for this residue in agonist-induced G-protein activation. ..
  52. Pathe Neuschäfer Rube A, Neuschäfer Rube F, Püschel G. Role of the ERC motif in the proximal part of the second intracellular loop and the C-terminal domain of the human prostaglandin F2alpha receptor (hFP-R) in G-protein coupling control. Biochem J. 2005;388:317-24 pubmed
    ..Thus C-terminal truncation appeared to result in a receptor with partial constitutive activation, whereas substitution of Glu132 by threonine apparently resulted in a receptor with full constitutive activity. ..
  53. Scott G, Jacobs S, Leopardi S, Anthony F, Learn D, Malaviya R, et al. Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation. Exp Cell Res. 2005;304:407-16 pubmed
    ..The regulation of the FP receptor and the stimulation of production of PGF2alpha in melanocytes in response to ultraviolet radiation suggest that PGF2alpha could act as an autocrine factor for melanocyte differentiation. ..
  54. Zaragoza D, Wilson R, Mitchell B, Olson D. The interleukin 1beta-induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial-derived ULTR cells requires the transcription factor, NFkappaB. Biol Reprod. 2006;75:697-704 pubmed
    ..The mRNA expression of the prostaglandin F(2alpha) receptor (PTGFR), a uterine activating gene, is increased at labor and is required for uterine contractile activity in numerous ..
  55. Kim S, Kim Y, Park H, Jee Y, Kim S, Bahn J, et al. Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Pharmacogenet Genomics. 2007;17:295-304 pubmed
    ..We screened for genetic variations in the prostanoid receptor genes PTGER1, PTGER2, PTGER3, PTGER4, PTGDR, PTGIR, PTGFR, and TBXA2R using direct sequencing, and selected 32 tagging single nucleotide polymorphisms among the 77 ..
  56. Guagnano M, Ferroni P, Santilli F, Paoletti V, Manigrasso M, Pescara L, et al. Determinants of platelet activation in hypertensives with microalbuminuria. Free Radic Biol Med. 2009;46:922-7 pubmed
    ..We conclude that lipid peroxidation is a major determinant of persistent platelet activation in hypertensive patients with microalbuminuria. ..
  57. Sales K, Grant V, Cook I, Maldonado Pérez D, Anderson R, Williams A, et al. Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1. Am J Pathol. 2010;176:435-45 pubmed publisher
    ..This study has highlighted a new mechanism regulating IL-11 expression in endometrial adenocarcinoma cells by the FP receptor via the calcium-calcineurin-nuclear factor of activated T cells pathway. ..
  58. Hay A, Wood S, Olson D, Slater D. Labour is associated with decreased expression of the PGF2alpha receptor (PTGFR) and a novel PTGFR splice variant in human myometrium but not decidua. Mol Hum Reprod. 2010;16:752-60 pubmed publisher
    The prostaglandin F(2?) receptor (PTGFR) is believed to play a role in the process of parturition. The main support for this comes from animal studies; however, in humans, the evidence is less clear...
  59. Wallace A, Catalano R, Anderson R, Jabbour H. Chemokine (C-C) motif ligand 20 is regulated by PGF(2?)-F-prostanoid receptor signalling in endometrial adenocarcinoma and promotes cell proliferation. Mol Cell Endocrinol. 2011;331:129-35 pubmed publisher
    ..Therefore these data demonstrate a role for the FP receptor in regulation of the chemokine CCL20, which can mediate proliferation of endometrial adenocarcinoma epithelial cells. ..
  60. Goupil E, Fillion D, Clément S, Luo X, Devost D, Sleno R, et al. Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells. J Biol Chem. 2015;290:3137-48 pubmed publisher
    ..AT1R/FP dimers may thus be important in the regulation of blood pressure. ..
  61. Zschockelt L, Amelkina O, Siemieniuch M, Kowalewski M, Dehnhard M, Jewgenow K, et al. Synthesis and reception of prostaglandins in corpora lutea of domestic cat and lynx. Reproduction. 2016;152:111-26 pubmed publisher
    ..mRNA and protein expression of PG synthases (PTGS2/COX2, PTGES, PGFS/AKR1C3) and PG receptors (PTGER2, PTGER4, PTGFR), and intra-luteal levels of PGE2 and PGF2? Therefore, CL of pregnant (pre-implantation, post-implantation, ..
  62. Duncan A, Anderson L, Funk C, Abramovitz M, Adam M. Chromosomal localization of the human prostanoid receptor gene family. Genomics. 1995;25:740-2 pubmed
    ..positions of the human genes that encode the PGE2 receptor subtypes (PTGER1, PTGER2, and PTGER3), the PGF2 alpha receptor (PTGFR), the PGI2 receptor (PTGIR), and the TXA2 receptor (TBXA2R) using in situ hybridization...
  63. Funk C, Furci L, Fitzgerald G, Grygorczyk R, Rochette C, Bayne M, et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem. 1993;268:26767-72 pubmed
    ..In summary, therefore, we have cloned the human EP1 receptor subtype which is functionally coupled to an increase in intracellular Ca2+. ..
  64. Chen X, Regan J. Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy. Cell Mol Life Sci. 2006;63:112-21 pubmed
    ..This suggests that FP receptor activation of Rho signaling by PGF(2alpha) can interfere with nuclear division. Aneuploidy is associated with genomic instability and may underlie the tumor-promoting properties of PGF(2alpha). ..
  65. Sakurai M, Higashide T, Takahashi M, Sugiyama K. Association between genetic polymorphisms of the prostaglandin F2alpha receptor gene and response to latanoprost. Ophthalmology. 2007;114:1039-45 pubmed
    ..The genotype of these SNPs may be an important determinant of variability in response to latanoprost. ..
  66. Sales K, Maldonado Pérez D, Grant V, Catalano R, Wilson M, Brown P, et al. Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway. Biochim Biophys Acta. 2009;1793:1917-28 pubmed publisher
  67. Chen D, Jiang X, Akula N, Shugart Y, Wendland J, Steele C, et al. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Mol Psychiatry. 2013;18:195-205 pubmed publisher
    ..The results suggest novel association findings near the genes TRANK1 (LBA1), LMAN2L and PTGFR. In phase I, the most significant single nucleotide polymorphism (SNP), rs9834970 near TRANK1, was significant at ..
  68. Sakurai M, Higashide T, Ohkubo S, Takeda H, Sugiyama K. Association between genetic polymorphisms of the prostaglandin F2? receptor gene, and response to latanoprost in patients with glaucoma and ocular hypertension. Br J Ophthalmol. 2014;98:469-73 pubmed publisher
    ..The FP receptor genetic polymorphism may influence the degree of IOP reduction by latanoprost in these patients. ..
  69. Gao L, Wang D, Liu F, Huang Z, Huang H, Wang G, et al. Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients. Eur J Clin Pharmacol. 2015;71:43-50 pubmed publisher
    ..the association between variants in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin F (2α) receptor (PTGFR), and multidrug resistance protein 4 (MRP4) genes and intraocular pressure (IOP) response to latanoprost in ..
  70. Yoda T, Kikuchi K, Miki Y, Onodera Y, Hata S, Takagi K, et al. 11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer. Mol Cell Endocrinol. 2015;413:236-47 pubmed publisher
    ..Overall these results indicated that the actions of AKR1C3 can produce FP receptor ligands whose activation results in carcinoma cell survival in breast cancer. ..
  71. Cheng Z, Abudureyimu A, Oguejiofor C, Ellis R, Barry A, Chen X, et al. BVDV alters uterine prostaglandin production during pregnancy recognition in cows. Reproduction. 2016;151:605-14 pubmed publisher
    ..The other tested genes, including PGR, ESR1, OXTR, PTGS2, PTGER2 and PTGFR, were not significantly altered by IFNT, ncpBVDV or their combination...
  72. Yonekura H, Sakurai S, Liu X, Migita H, Wang H, Yamagishi S, et al. Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem. 1999;274:35172-8 pubmed
    ..Furthermore, antisense inhibition of PlGF protein production lowered the endothelial cell synthesis of DNA under hypoxic conditions. The results suggest that these VEGF family members may also take active parts in angiogenesis. ..
  73. Mandal A, Ray R, Zhang Z, Chowdhury B, Pattabiraman N, Mukherjee A. Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. J Biol Chem. 2005;280:32897-904 pubmed
    ..We propose that uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response. ..
  74. Wang S, Yang Q, Fung K, Lin H. AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. Mol Cell Endocrinol. 2008;289:60-6 pubmed publisher
    ..Overexpression of AKR1C2 or AKR1C3 did not alter levels of PGF receptor (FP) expression...
  75. Liang Y, Woodward D, Guzman V, Li C, Scott D, Wang J, et al. Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes. Br J Pharmacol. 2008;154:1079-93 pubmed publisher
    ..Hence, FP-altFP complexes may represent the underlying basis of bimatoprost pharmacology. ..
  76. Riise J, Nguyen C, Qvigstad E, Sandnes D, Osnes J, Skomedal T, et al. Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation. Cardiovasc Res. 2008;80:407-15 pubmed publisher
    ..Therefore, FPR signalling mechanism(s) regulating MLC-2 phosphorylation likely extend beyond those classically established for G(q/11)-coupled receptors. ..
  77. Errasti A, del Rey G, Cesio C, Souza G, Nowak W, Pelorosso F, et al. Expression and functional evidence of the prostaglandin F2alpha receptor mediating contraction in human umbilical vein. Eur J Pharmacol. 2009;610:68-74 pubmed publisher
    ..In all samples, clear signal was detected for cDNA amplification of prostanoid FP receptor and the specific prostanoid FP-receptor antibody recognized a protein of approximately 64 kDa...
  78. Keightley M, Brown P, Jabbour H, Sales K. F-Prostaglandin receptor regulates endothelial cell function via fibroblast growth factor-2. BMC Cell Biol. 2010;11:8 pubmed publisher
  79. Chang M, Chen Y, Lee M, Lin L, Wang T, Chan C, et al. Prostaglandin F(2alpha) stimulates MEK-ERK signalling but decreases the expression of alkaline phosphatase in dental pulp cells. Int Endod J. 2010;43:461-8 pubmed publisher
    ..PGF(2alpha) attenuated the ALP activity of pulp cells possibly via pathways not solely by MEK/ERK activation. PGF(2alpha) is a contributing factor of pulpal inflammation by regulating the activities of pulp cells. ..
  80. Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, et al. The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma. Pathol Int. 2013;63:37-44 pubmed publisher
    ..Among these genes, the expression levels of prostaglandin F receptor (PTGFR) mRNA, which encodes the prostaglandin F receptor (FP), were higher in TECs than in NECs...
  81. Simino J, Sung Y, Kume R, Schwander K, Rao D. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. Front Genet. 2013;4:277 pubmed publisher
    ..SNP-alcohol interactions may enhance discovery of novel variants with large effects that can be targeted with lifestyle modifications. ..
  82. Sleno R, Devost D, Pétrin D, Zhang A, Bourque K, Shinjo Y, et al. Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2? receptors. J Biol Chem. 2017;292:12139-12152 pubmed publisher
    ..The identification of partner-induced GPCR conformations may help identify novel allosteric effects when investigating multiprotein receptor signaling complexes. ..
  83. Liu B, Yang J, Luo W, Zhang Y, Li J, Li H, et al. Prostaglandin D2 is the major cyclooxygenase-1-derived product in prepartum mouse uteri where it mediates an enhanced in vitro myometrial contraction. Eur J Pharmacol. 2017;813:140-146 pubmed publisher
  84. Betz R, Lagercrantz J, Kedra D, Dumanski J, Nordenskjold A. Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene. Biochem Biophys Res Commun. 1999;254:413-6 pubmed
    ..1 using FISH and radiation hybrids analysis. The PGF receptor (FP) is highly expressed in mouse tissues especially in the corpora lutea in ovaries and in the kidney...
  85. Zaragoza D, Wilson R, Eyster K, Olson D. Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene. Biochim Biophys Acta. 2004;1676:193-202 pubmed
    ..DNase I footprinting analysis of this region identifies a footprint over the GATA-like site at -2400. This suggests repression of basal FP transcription may be mediated by a GATA binding site. ..
  86. Sugino N, Karube Harada A, Taketani T, Sakata A, Nakamura Y. Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation. J Reprod Dev. 2004;50:215-25 pubmed
    ..In conclusion, EP-withdrawal stimulates COX-2 expression and PGF2alpha production through ROS-induced NF-kappaB activation, suggesting a possible mechanism for menstruation. ..
  87. Makino S, Zaragoza D, Mitchell B, Yonemoto H, Olson D. Decidual activation: abundance and localization of prostaglandin F2alpha receptor (FP) mRNA and protein and uterine activation proteins in human decidua at preterm birth and term birth. Placenta. 2007;28:557-65 pubmed
    ..These results suggest that the induction of Prostaglandin F(2alpha) receptor at term may facilitate the decidua contribution to parturition, and its regulation and role should be examined further. ..
  88. Liedman R, Hansson S, Igidbashian S, Akerlund M. Myometrial oxytocin receptor mRNA concentrations at preterm and term delivery - the influence of external oxytocin. Gynecol Endocrinol. 2009;25:188-93 pubmed publisher
    ..009). PGF(2alpha) receptor mRNA concentrations were 27.80 +/- 3.55, 11.46 +/- 2.87 and 19.54 +/- 5.52 PGF receptor/actin, respectively, for the groups...
  89. McCarty C, Berg R, Patchett R, Wilke R, Burmester J. Lack of association between polymorphisms in the prostaglandin F2α receptor and solute carrier organic anion transporter family 2A1 genes and intraocular pressure response to prostaglandin analogs. Ophthalmic Genet. 2012;33:74-6 pubmed publisher
    To evaluate the association between variants in the prostaglandin F(α) receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and intraocular pressure (IOP) response to prostaglandin analogs...
  90. Ussa F, Fernandez I, Brion M, Carracedo A, Blázquez F, Garcia M, et al. Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma. Ophthalmology. 2015;122:1040-8.e4 pubmed publisher
    ..SNPs) of genes coding for matrix metalloproteinases (MMPs) and the prostaglandin F2α receptor gene (PTGFR) are related to a response to latanoprost in a white Spanish population of glaucomatous patients...
  91. Lappas M. The Adaptor Protein p62 Mediates Nuclear Factor ?B Activation in Response to Inflammation and Facilitates the Formation of Prolabor Mediators in Human Myometrium. Reprod Sci. 2017;24:762-772 pubmed publisher
    ..In addition, siRNA knockdown of p62 significantly suppressed IL-1?- and TNF-?-induced NF-?B activation. Collectively, these studies suggest that p62 is involved in the genesis of NF-?B-induced proinflammatory and prolabor mediators. ..
  92. Aliancy J, Stamer W, Wirostko B. A Review of Nitric Oxide for the Treatment of Glaucomatous Disease. Ophthalmol Ther. 2017;6:221-232 pubmed publisher