PTGES3

Summary

Gene Symbol: PTGES3
Description: prostaglandin E synthase 3
Alias: P23, TEBP, cPGES, prostaglandin E synthase 3, Hsp90 co-chaperone, cytosolic prostaglandin E synthase, cytosolic prostaglandin E2 synthase, progesterone receptor complex p23, prostaglandin E synthase 3 (cytosolic), telomerase-binding protein p23, unactive progesterone receptor, 23 kD
Species: human
Products:     PTGES3

Top Publications

  1. McLaughlin S, Sobott F, Yao Z, Zhang W, Nielsen P, Grossmann J, et al. The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J Mol Biol. 2006;356:746-58 pubmed
    ..Here, we have examined the inhibition of the ATPase activity of human Hsp90beta by one such co-chaperone, human p23. We demonstrate that human p23 interacts with Hsp90 in both the absence and presence of nucleotide with a higher ..
  2. Nair S, Toran E, Rimerman R, Hjermstad S, Smithgall T, Smith D. A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones. 1996;1:237-50 pubmed
    ..These proteins are Hsp90, Hsp70, Hip, p60, p23, FKBP51, FKBP52 and Cyp40...
  3. Johnson J, Beito T, Krco C, Toft D. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol. 1994;14:1956-63 pubmed
    ..progesterone receptor results in the copurification of hsp90, hsp70, and three additional proteins, p54, p50, and p23. p23 is also present in immunoaffinity-purified hsp90 complexes along with hsp70 and another protein, p60...
  4. Morishima Y, Kanelakis K, Murphy P, Lowe E, Jenkins G, Osawa Y, et al. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem. 2003;278:48754-63 pubmed
    ..by a multiprotein machinery, including hsp90 and hsp70 as essential and abundant components and Hop, hsp40, and p23 as non-essential cochaperones that are present in much lower abundance in cells...
  5. Freeman B, Yamamoto K. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science. 2002;296:2232-5 pubmed
    ..Here, we show that the p23 molecular chaperone localizes in vivo to genomic response elements in a hormone-dependent manner, disrupting ..
  6. Kazlauskas A, Poellinger L, Pongratz I. The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. J Biol Chem. 2000;275:41317-24 pubmed
    ..The nonactivated form of the dioxin receptor is associated with heat shock protein (hsp) 90, the co-chaperone p23, and the immunophilin-like protein XAP2...
  7. Dittmar K, Pratt W. Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. J Biol Chem. 1997;272:13047-54 pubmed
    ..hsp90 heterocomplex assembly system with purified rabbit hsp90 and hsp70 and bacterially expressed human p23 and p60 (Dittmar, K. D., Hutchison, K. A., Owens-Grillo, J. K., and Pratt, W. B. (1996) J. Biol. Chem...
  8. Karagöz G, Duarte A, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, et al. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proc Natl Acad Sci U S A. 2011;108:580-5 pubmed publisher
    ..by NMR spectroscopy in solution, and we elucidated the mechanism of the inhibition of its ATPase by its cochaperone p23. We assigned isoleucine side chains of Hsp90 via specific isotope labeling of their δ-methyl groups, which allowed ..
  9. Obermann W, Sondermann H, Russo A, Pavletich N, Hartl F. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol. 1998;143:901-10 pubmed
    ..mutant Hsp90 proteins tested are defective in the binding and ATP hydrolysis-dependent cycling of the co-chaperone p23, which is thought to regulate the binding and release of substrate polypeptide from Hsp90...
  10. Ni L, Yang C, Gioeli D, Frierson H, Toft D, Paschal B. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol Cell Biol. 2010;30:1243-53 pubmed publisher
    ..Using recombinant proteins, we show that FKBP51 stimulates recruitment of the cochaperone p23 to the ATP-bound form of Hsp90, forming an FKBP51-Hsp90-p23 superchaperone complex...

Detail Information

Publications62

  1. McLaughlin S, Sobott F, Yao Z, Zhang W, Nielsen P, Grossmann J, et al. The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J Mol Biol. 2006;356:746-58 pubmed
    ..Here, we have examined the inhibition of the ATPase activity of human Hsp90beta by one such co-chaperone, human p23. We demonstrate that human p23 interacts with Hsp90 in both the absence and presence of nucleotide with a higher ..
  2. Nair S, Toran E, Rimerman R, Hjermstad S, Smithgall T, Smith D. A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones. 1996;1:237-50 pubmed
    ..These proteins are Hsp90, Hsp70, Hip, p60, p23, FKBP51, FKBP52 and Cyp40...
  3. Johnson J, Beito T, Krco C, Toft D. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol. 1994;14:1956-63 pubmed
    ..progesterone receptor results in the copurification of hsp90, hsp70, and three additional proteins, p54, p50, and p23. p23 is also present in immunoaffinity-purified hsp90 complexes along with hsp70 and another protein, p60...
  4. Morishima Y, Kanelakis K, Murphy P, Lowe E, Jenkins G, Osawa Y, et al. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem. 2003;278:48754-63 pubmed
    ..by a multiprotein machinery, including hsp90 and hsp70 as essential and abundant components and Hop, hsp40, and p23 as non-essential cochaperones that are present in much lower abundance in cells...
  5. Freeman B, Yamamoto K. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science. 2002;296:2232-5 pubmed
    ..Here, we show that the p23 molecular chaperone localizes in vivo to genomic response elements in a hormone-dependent manner, disrupting ..
  6. Kazlauskas A, Poellinger L, Pongratz I. The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. J Biol Chem. 2000;275:41317-24 pubmed
    ..The nonactivated form of the dioxin receptor is associated with heat shock protein (hsp) 90, the co-chaperone p23, and the immunophilin-like protein XAP2...
  7. Dittmar K, Pratt W. Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. J Biol Chem. 1997;272:13047-54 pubmed
    ..hsp90 heterocomplex assembly system with purified rabbit hsp90 and hsp70 and bacterially expressed human p23 and p60 (Dittmar, K. D., Hutchison, K. A., Owens-Grillo, J. K., and Pratt, W. B. (1996) J. Biol. Chem...
  8. Karagöz G, Duarte A, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, et al. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proc Natl Acad Sci U S A. 2011;108:580-5 pubmed publisher
    ..by NMR spectroscopy in solution, and we elucidated the mechanism of the inhibition of its ATPase by its cochaperone p23. We assigned isoleucine side chains of Hsp90 via specific isotope labeling of their δ-methyl groups, which allowed ..
  9. Obermann W, Sondermann H, Russo A, Pavletich N, Hartl F. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol. 1998;143:901-10 pubmed
    ..mutant Hsp90 proteins tested are defective in the binding and ATP hydrolysis-dependent cycling of the co-chaperone p23, which is thought to regulate the binding and release of substrate polypeptide from Hsp90...
  10. Ni L, Yang C, Gioeli D, Frierson H, Toft D, Paschal B. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol Cell Biol. 2010;30:1243-53 pubmed publisher
    ..Using recombinant proteins, we show that FKBP51 stimulates recruitment of the cochaperone p23 to the ATP-bound form of Hsp90, forming an FKBP51-Hsp90-p23 superchaperone complex...
  11. Brychzy A, Rein T, Winklhofer K, Hartl F, Young J, Obermann W. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J. 2003;22:3613-23 pubmed
    ..At normal levels substoichiometric to Hsp90 and Hsp70, this activity optimizes the function of the multichaperone machinery. ..
  12. Wochnik G, Young J, Schmidt U, Holsboer F, Hartl F, Rein T. Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90. FEBS Lett. 2004;560:35-8 pubmed
    b>p23 is a regulatory co-chaperone of heat shock protein (Hsp) 90, but can also act as a general molecular chaperone by itself...
  13. Dittmar K, Demady D, Stancato L, Krishna P, Pratt W. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70. J Biol Chem. 1997;272:21213-20 pubmed
    ..hsp90 assembly system containing four required components, hsp90, hsp70, p60, and p23 (Dittmar, K. D., Hutchison, K. A., Owens-Grillo, J. K., and Pratt, W. B. (1996) J. Biol. Chem. 271, 12833-12839)...
  14. Martinez Yamout M, Venkitakrishnan R, Preece N, Kroon G, Wright P, Dyson H. Localization of sites of interaction between p23 and Hsp90 in solution. J Biol Chem. 2006;281:14457-64 pubmed
    The co-chaperone p23 forms a complex with the chaperone Hsp90 that mediates the folding pathway leading to the production of functional steroid receptors...
  15. Gano J, Simon J. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Mol Cell Proteomics. 2010;9:255-70 pubmed publisher
    ..Together these findings suggest that the HSP90 interactome is dynamic with respect to nucleotide and drug ligands and that pharmacological inhibition of HSP90 may stimulate the formation of specific complexes. ..
  16. Kuang J, Abdallah M, Harrad S. Brominated flame retardants in black plastic kitchen utensils: Concentrations and human exposure implications. Sci Total Environ. 2018;610-611:1138-1146 pubmed publisher
    ..EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), bis(2-ethylhexyl)-3,4,5,6-tetrabromo-phthalate (BEH-TEBP) and decabromodiphenyl ethane (DBDPE)...
  17. Mollapour M, Tsutsumi S, Donnelly A, Beebe K, Tokita M, Lee M, et al. Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mol Cell. 2010;37:333-43 pubmed publisher
    ....
  18. Cano L, Lavery D, Sin S, Spanjaard E, Brooke G, Tilman J, et al. The co-chaperone p23 promotes prostate cancer motility and metastasis. Mol Oncol. 2015;9:295-308 pubmed publisher
    ..b>p23, an essential component of the apo-AR complex, acts also after ligand binding to increase AR transcriptional ..
  19. Yin J, Xia W, Li Y, Guo C, Zhang Y, Huang S, et al. COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells. Am J Transl Res. 2017;9:3967-3976 pubmed
    ..At the same time, we observed a dose-dependent upregulation of another two PGE2 synthases of mPGES-2 and cPGES determined by qRT-PCR...
  20. Skalova A, Stenman G, Simpson R, Hellquist H, Slouka D, Svoboda T, et al. The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas. Am J Surg Pathol. 2017;: pubmed publisher
    ..A t(6;9)(q22-23;p23-34) translocation resulting in a MYB-NFIB gene fusion has been identified in the majority of adenoid cystic ..
  21. Woo S, An S, Lee H, Jin H, Seo S, Yoo D, et al. A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J Biol Chem. 2009;284:30871-80 pubmed publisher
    The Hsp90-associated protein p23 modulates Hsp90 activity during the final stages of the chaperone pathway to facilitate maturation of client proteins...
  22. Echtenkamp F, Gvozdenov Z, Adkins N, Zhang Y, Lynch Day M, Watanabe S, et al. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler. Mol Cell. 2016;64:888-899 pubmed publisher
    ..The significance of these connections is poorly understood. To delineate why Hsp90 and its cochaperone p23 interact with a mature structure, we focused on the RSC chromatin remodeler...
  23. Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem. 2000;275:32775-82 pubmed
    ..we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (cPGES), a terminal enzyme of the cyclooxygenase (COX)-1-mediated PGE(2) biosynthetic pathway...
  24. Simpson N, Gertz J, Imberg K, Myers R, Garabedian M. Research resource: enhanced genome-wide occupancy of estrogen receptor α by the cochaperone p23 in breast cancer cells. Mol Endocrinol. 2012;26:194-202 pubmed publisher
    b>p23 is a chaperone with multiple heat shock protein 90 dependent and independent cellular functions, including stabilizing unliganded steroid receptors and modulating receptor-DNA dynamics...
  25. Sun L, Prince T, Manjarrez J, Scroggins B, Matts R. Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012;1823:1092-101 pubmed publisher
    ..Complexes formed by Aha1 with Hsp90 in RRL were stabilized by molybdate and contained the co-chaperones FKBP52 and p23/Sba1, but lacked HOP/Sti1 and Cdc37...
  26. Bartsch K, Hombach Barrigah A, Clos J. Hsp90 inhibitors radicicol and geldanamycin have opposing effects on Leishmania Aha1-dependent proliferation. Cell Stress Chaperones. 2017;: pubmed publisher
    ..Activity of Hsp90 is regulated by co-chaperones of the Aha1 and P23 families. In this paper, we studied the expression of L...
  27. Chaudhry U, DORE S. Cytosolic prostaglandin E synthase: expression patterns in control and Alzheimer's disease brains. Am J Alzheimers Dis Other Demen. 2009;24:46-51 pubmed publisher
    ..These findings revealed that cytosolic prostaglandin E(2) synthases is found in microglia, neurons, and endothelium of control human middle frontal gyrus and that its levels decrease in pyramidal cells of Alzheimer's disease brains. ..
  28. Kumar S, Connor J, Dodds R, Halsey W, Van Horn M, Mao J, et al. Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. Osteoarthritis Cartilage. 2001;9:641-53 pubmed
    ..Further analysis of genes identified from these libraries may provide molecular targets for diagnosis and/or treatment of osteoarthritis (OA). ..
  29. Chan C, Paulmurugan R, Gheysens O, Kim J, Chiosis G, Gambhir S. Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer Res. 2008;68:216-26 pubmed publisher
    Heat shock protein 90 alpha (Hsp90 alpha)/p23 and Hsp90 beta/p23 interactions are crucial for proper folding of proteins involved in cancer and neurodegenerative diseases...
  30. Lee J, Chung I. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 2010;290:76-86 pubmed publisher
    The molecular chaperone complex Hsp90-p23 interacts with the rate-limiting catalytic subunit of telomerase, hTERT...
  31. Kazlauskas A, Sundstrom S, Poellinger L, Pongratz I. The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Mol Cell Biol. 2001;21:2594-607 pubmed
    The molecular chaperone complex hsp90-p23 interacts with the dioxin receptor, a ligand-dependent basic helix-loop-helix (bHLH)/Per-Arnt-Sim domain transcription factor...
  32. Ooi W, Murayama Y, Mekler V, Minakhin L, Severinov K, Yokoyama S, et al. A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation. Nucleic Acids Res. 2017;: pubmed publisher
    RNA polymerase (RNAP) is a major target of gene regulation. Thermus thermophilus bacteriophage P23-45 encodes two RNAP binding proteins, gp39 and gp76, which shut off host gene transcription while allowing orderly transcription of phage ..
  33. Sinclair D, Fillman S, Webster M, Weickert C. Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness. Sci Rep. 2013;3:3539 pubmed publisher
    ..totaling 55 schizophrenia, 34 bipolar disorder and 55 control individuals, we identified increased FKBP5 and PTGES3 mRNA expression, and decreased BAG1 mRNA expression, in the prefrontal cortex in schizophrenia cases relative to ..
  34. Sugumaran A, Ponnusamy C, Kandasamy P, Krishnaswami V, Palanichamy R, Kandasamy R, et al. Development and evaluation of camptothecin loaded polymer stabilized nanoemulsion: Targeting potential in 4T1-breast tumour xenograft model. Eur J Pharm Sci. 2017;: pubmed publisher
    ..pseudo-ternary phase diagrams, PSNEs were developed using capmul MCM:poloxamer 407 (4:1), solutol HS 15:simulsol P23 (1:2) and water. CPT polymer mixture was developed by solvent evaporation technique...
  35. Han R, Tsui S, Smith T. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression. J Biol Chem. 2002;277:16355-64 pubmed
    ..b>cPGES is cytoplasmic, apparently identical to the hsp90 chaperone, p23, and associates functionally with prostaglandin-..
  36. Liu X, Zou L, Zhu L, Zhang H, Du C, Li Z, et al. miRNA mediated up-regulation of cochaperone p23 acts as an anti-apoptotic factor in childhood acute lymphoblastic leukemia. Leuk Res. 2012;36:1098-104 pubmed publisher
    b>p23 is a heat shock protein 90 (Hsp90) cochaperone that plays a significant role in estrogen receptor (ER) alpha signal transduction and telomerase activity; it is up-regulated in several cancers...
  37. Holt S, Aisner D, Baur J, Tesmer V, Dy M, Ouellette M, et al. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 1999;13:817-26 pubmed
    ..We have identified the molecular chaperones p23 and Hsp90 as proteins that bind to the catalytic subunit of telomerase...
  38. Chen T, Keeney M, Chintakuntlawar A, Knutson D, Kloft Nelson S, Greipp P, et al. Adenoid cystic carcinoma of the lacrimal gland is frequently characterized by MYB rearrangement. Eye (Lond). 2017;31:720-725 pubmed publisher
    ..is frequently characterized by a fusion transcript involving genes MYB and NFIB; more specifically, t(6;9)(q22-23;p23-24)...
  39. McLaughlin S, Smith H, Jackson S. Stimulation of the weak ATPase activity of human hsp90 by a client protein. J Mol Biol. 2002;315:787-98 pubmed
    ..proteins, respectively), as well as high molecular mass immunophilins, such as FKBP59, and the small acidic protein p23. The role of these proteins in Hsp90-mediated assembly processes is poorly understood...
  40. Pare J, LaPointe P, Hobman T. Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells. Mol Biol Cell. 2013;24:2303-10 pubmed publisher
    ..Here we show that the Hsp90 cochaperones Cdc37, Aha1, FKBP4, and p23 are required for efficient RNAi...
  41. Shimamura T, Perera S, Foley K, Sang J, Rodig S, Inoue T, et al. Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin Cancer Res. 2012;18:4973-85 pubmed publisher
    ..We describe the anticancer activity of ganetespib, a novel non-geldanamycin heat shock protein 90 (HSP90) inhibitor, in non-small cell lung cancer (NSCLC) models...
  42. Boucher D, Blais V, Denault J. Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis. Proc Natl Acad Sci U S A. 2012;109:5669-74 pubmed publisher
    ..sequence preference as caspase-3, is better at cleaving poly(ADP ribose) polymerase 1 (PARP) and Hsp90 cochaperone p23, despite a lower intrinsic activity...
  43. Ge X, Rameix Welti M, Gault E, Chase G, Dos Santos Afonso E, Picard D, et al. Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response. PLoS ONE. 2011;6:e23368 pubmed publisher
    ..Here we report that the p23 cochaperone of Hsp90, which plays a major role in glucocorticoid receptor folding and function, associates with ..
  44. Meadows J, Eis A, Brockman D, Myatt L. Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor. J Clin Endocrinol Metab. 2003;88:433-9 pubmed
    ..Cytosolic PGES (cPGES) is identical to the heat shock protein 90 chaperone, p23, and is reportedly functionally coupled to constitutive ..
  45. Cullen S, Adrain C, Lüthi A, Duriez P, Martin S. Human and murine granzyme B exhibit divergent substrate preferences. J Cell Biol. 2007;176:435-44 pubmed
    ..These data demonstrate that human and murine GzmB are distinct enzymes with different substrate preferences. Our observations also illustrate how subtle differences in enzyme structure can radically affect substrate selection. ..
  46. Oxelmark E, Roth J, Brooks P, Braunstein S, Schneider R, Garabedian M. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol. 2006;26:5205-13 pubmed
    The cochaperone p23 plays an important role in estrogen receptor alpha (ER) signal transduction. In this study, we investigated how p23 regulates ER target gene activation and affects tumor growth and progression...
  47. Naruse K, Matsuura Suzuki E, Watanabe M, Iwasaki S, Tomari Y. In vitro reconstitution of chaperone-mediated human RISC assembly. RNA. 2018;24:6-11 pubmed publisher
    ..of human RISC assembly using Ago2 and five recombinant chaperone proteins: Hsp90β, Hsc70, Hop, Dnaja2, and p23. Our data show that ATP hydrolysis by both Hsp90β and Hsc70 is required for RISC assembly of small RNA duplexes ..
  48. Cechova E, Vojta Š, Kukucka P, Kocan A, Trnovec T, Murinova L, et al. Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health. Environ Int. 2017;108:137-145 pubmed publisher
    ..The Penta-BDE replacement, bis(2-ethylhexyl) tetrabromophthalate, BEH-TEBP, was present at the greatest concentrations of any of the AFRs and in some samples exceeded concentrations of BDE ..
  49. Hernández M, Chadli A, Toft D. HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. J Biol Chem. 2002;277:11873-81 pubmed
    ..However, an in vitro chaperoning system consisting of five proteins (HSP40, HSP70, HOP, HSP90, and p23) with ATP is capable of restoring this function...
  50. Cox M, Miller C. The p23 co-chaperone facilitates dioxin receptor signaling in a yeast model system. Toxicol Lett. 2002;129:13-21 pubmed
    Hsp90, p23 and other chaperosome proteins are critical for the function of several enzymes and steroid hormone receptors...
  51. Zhang Y, Yang B, Tang X, Chen S, Yu R, He J, et al. [Genetic analysis and prenatal diagnosis for a pregnant woman with an unbalanced t(1;2), t(6;7) translocation and intellectual disability]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:583-587 pubmed publisher
    ..an apparently balanced translocation involving chromosomes 1, 2, 6 and 7, with a karyotype of 46, XX, t(1;2) (p22;p23), t(6;7) (q21;p15). The karyotype of her fetus was ascertained as 46, XY, t(6;7) (q21;p15) mat...
  52. Kudo I, Hosaka M, Haga A, Tsuji N, Nagata Y, Okada H, et al. The regulation mechanisms of AhR by molecular chaperone complex. J Biochem. 2017;: pubmed publisher
    ..The ligand-free AhR forms a cytosolic protein complex with the molecular chaperone HSP90, co-chaperone p23, and XAP2 in the cytoplasm...
  53. Huang N, Wang C, Zhang N, Mao W, Liu B, Shen Y, et al. Effect of estrogen on prostaglandin synthetase in bovine oviduct smooth muscle. Eur J Pharmacol. 2018;818:287-293 pubmed publisher
    ..prostaglandin-endoperoxide synthase-1 (PTGS1), prostaglandin-endoperoxide synthase-2 (PTGS2), mPGES-1, mPGES-2, cPGES, and PGFS) by estradiol (E2) in bovine oviduct smooth muscle...
  54. Nkabinde S, Okonkwo J, Olukunle O, Daso A. Determination of legacy and novel brominated flame retardants in dust from end of life office equipment and furniture from Pretoria, South Africa. Sci Total Environ. 2017;622-623:275-281 pubmed publisher
    ..However, Bis (2-ethylhexyl) tetrabromophthalate (BEH-TEBP) was only detected in 24% of the 21 samples exhibiting a concentration range of <LOD - 63ngg-1...
  55. Giommarelli C, Zuco V, Favini E, Pisano C, Dal Piaz F, De Tommasi N, et al. The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. Cell Mol Life Sci. 2010;67:995-1004 pubmed publisher
    ....
  56. Picard D. Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90. Exp Cell Res. 2006;312:198-204 pubmed
    b>p23 is a component of the Hsp90 molecular chaperone machine. It binds and stabilizes the ATP-bound dimeric form of Hsp90...
  57. Bommer U. The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation. Results Probl Cell Differ. 2017;64:69-126 pubmed publisher
    The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in ..
  58. Wu L, Xu J, Huang X, Zhang K, Wen C, Chen Y. Down-regulation of p210(bcr/abl) by curcumin involves disrupting molecular chaperone functions of Hsp90. Acta Pharmacol Sin. 2006;27:694-9 pubmed
    ..Flow cytometry and Western blot were used to examine the abundance of p210(bcr/abl), Hsp90, p23, Hsp70, and p60(Hop) in K562 cells treated with Cur...
  59. Sarkar A, Ghosh P, Pramanik K, Mitra S, Soren T, Pandey S, et al. A halotolerant Enterobacter sp. displaying ACC deaminase activity promotes rice seedling growth under salt stress. Res Microbiol. 2018;169:20-32 pubmed publisher
    ..Among them, strain P23, identified as an Enterobacter sp...
  60. Song D, Li L, Heaton Johnson K, Arsenault P, Master S, Lee F. Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway. J Biol Chem. 2013;288:9662-74 pubmed publisher
    ..In this report we show that the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38 interact via a conserved Pro-Xaa-Leu-Glu motif (where Xaa = any amino acid) in these proteins with the N-..
  61. Chen W, Stambolian D, Edwards A, Branham K, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6 pubmed publisher
    ..Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies. ..
  62. Picard D, Suslova E, Briand P. 2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex. Exp Cell Res. 2006;312:3949-58 pubmed
    The abundant molecular chaperone Hsp90 functions in association with co-chaperones including p23 to promote the folding and maturation of a subset of cytosolic proteins...