PTGES3

Summary

Gene Symbol: PTGES3
Description: prostaglandin E synthase 3
Alias: P23, TEBP, cPGES, prostaglandin E synthase 3, Hsp90 co-chaperone, cytosolic prostaglandin E synthase, cytosolic prostaglandin E2 synthase, progesterone receptor complex p23, prostaglandin E synthase 3 (cytosolic), telomerase-binding protein p23, unactive progesterone receptor, 23 kD
Species: human
Products:     PTGES3

Top Publications

  1. Johnson J, Beito T, Krco C, Toft D. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol. 1994;14:1956-63 pubmed
    ..progesterone receptor results in the copurification of hsp90, hsp70, and three additional proteins, p54, p50, and p23. p23 is also present in immunoaffinity-purified hsp90 complexes along with hsp70 and another protein, p60...
  2. Nair S, Toran E, Rimerman R, Hjermstad S, Smithgall T, Smith D. A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones. 1996;1:237-50 pubmed
    ..These proteins are Hsp90, Hsp70, Hip, p60, p23, FKBP51, FKBP52 and Cyp40...
  3. Kazlauskas A, Poellinger L, Pongratz I. The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. J Biol Chem. 2000;275:41317-24 pubmed
    ..The nonactivated form of the dioxin receptor is associated with heat shock protein (hsp) 90, the co-chaperone p23, and the immunophilin-like protein XAP2...
  4. Freeman B, Yamamoto K. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science. 2002;296:2232-5 pubmed
    ..Here, we show that the p23 molecular chaperone localizes in vivo to genomic response elements in a hormone-dependent manner, disrupting ..
  5. Morishima Y, Kanelakis K, Murphy P, Lowe E, Jenkins G, Osawa Y, et al. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem. 2003;278:48754-63 pubmed
    ..by a multiprotein machinery, including hsp90 and hsp70 as essential and abundant components and Hop, hsp40, and p23 as non-essential cochaperones that are present in much lower abundance in cells...
  6. McLaughlin S, Sobott F, Yao Z, Zhang W, Nielsen P, Grossmann J, et al. The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J Mol Biol. 2006;356:746-58 pubmed
    ..Here, we have examined the inhibition of the ATPase activity of human Hsp90beta by one such co-chaperone, human p23. We demonstrate that human p23 interacts with Hsp90 in both the absence and presence of nucleotide with a higher ..
  7. Dittmar K, Pratt W. Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. J Biol Chem. 1997;272:13047-54 pubmed
    ..hsp90 heterocomplex assembly system with purified rabbit hsp90 and hsp70 and bacterially expressed human p23 and p60 (Dittmar, K. D., Hutchison, K. A., Owens-Grillo, J. K., and Pratt, W. B. (1996) J. Biol. Chem...
  8. Obermann W, Sondermann H, Russo A, Pavletich N, Hartl F. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol. 1998;143:901-10 pubmed
    ..mutant Hsp90 proteins tested are defective in the binding and ATP hydrolysis-dependent cycling of the co-chaperone p23, which is thought to regulate the binding and release of substrate polypeptide from Hsp90...
  9. Karagöz G, Duarte A, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, et al. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proc Natl Acad Sci U S A. 2011;108:580-5 pubmed publisher
    ..by NMR spectroscopy in solution, and we elucidated the mechanism of the inhibition of its ATPase by its cochaperone p23. We assigned isoleucine side chains of Hsp90 via specific isotope labeling of their ?-methyl groups, which allowed ..

More Information

Publications114 found, 100 shown here

  1. Brychzy A, Rein T, Winklhofer K, Hartl F, Young J, Obermann W. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J. 2003;22:3613-23 pubmed
    ..At normal levels substoichiometric to Hsp90 and Hsp70, this activity optimizes the function of the multichaperone machinery. ..
  2. Wochnik G, Young J, Schmidt U, Holsboer F, Hartl F, Rein T. Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90. FEBS Lett. 2004;560:35-8 pubmed
    b>p23 is a regulatory co-chaperone of heat shock protein (Hsp) 90, but can also act as a general molecular chaperone by itself...
  3. Ni L, Yang C, Gioeli D, Frierson H, Toft D, Paschal B. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol Cell Biol. 2010;30:1243-53 pubmed publisher
    ..Using recombinant proteins, we show that FKBP51 stimulates recruitment of the cochaperone p23 to the ATP-bound form of Hsp90, forming an FKBP51-Hsp90-p23 superchaperone complex...
  4. Dittmar K, Demady D, Stancato L, Krishna P, Pratt W. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70. J Biol Chem. 1997;272:21213-20 pubmed
    ..hsp90 assembly system containing four required components, hsp90, hsp70, p60, and p23 (Dittmar, K. D., Hutchison, K. A., Owens-Grillo, J. K., and Pratt, W. B. (1996) J. Biol. Chem. 271, 12833-12839)...
  5. Ni H, Chen S, Li L, Jin M. Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin. Biol Trace Elem Res. 2018;: pubmed publisher
    ..righting reflex, cliff avoidance reflex, forelimb suspension reflex, and open field test) were observed from P23 to P30...
  6. Li L, Li Y, Zhao D, Jin M, Ni H. Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex. Epilepsy Res. 2018;146:103-111 pubmed publisher
    ..reflex, righting reflex, cliff avoidance reflex, forelimb suspension reflex and open field test) were observed from P23 to P30...
  7. Dhamad A, Zhou Z, Zhou J, Du Y. Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ER?) and Biochemical Characterization of the ER?-Hsp70 Interaction. PLoS ONE. 2016;11:e0160312 pubmed publisher
    ..Among the reported Hsp cochaperones, we detected prostaglandin E synthase 3 (p23), peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP51), and E3 ubiquitin-protein ligase CHIP (CHIP)...
  8. Jeong Y, Her J, Oh S, Chung I. Hsp90-binding immunophilin FKBP52 modulates telomerase activity by promoting the cytoplasmic retrotransport of hTERT. Biochem J. 2016;473:3517-3532 pubmed
    ..The molecular chaperones heat shock protein 90 (Hsp90) and p23 maintain hTERT in a conformation that enables nuclear translocation...
  9. Chen C, Ko T, Huang W, Chern S, Wu P, Chen Y, et al. Molecular cytogenetic characterization of inv dup del(8p) in a fetus associated with ventriculomegaly, hypoplastic left heart, polyhydramnios and intestinal obstruction. Taiwan J Obstet Gynecol. 2016;55:415-8 pubmed publisher
    ..Conventional cytogenetic analysis was applied on parental bloods. aCGH detected an 11.35 Mb deletion in 8p23.3-p23.1 encompassing SOX7 and GATA4, and a 31.99 Mb duplication in 8p23.1-p11.1 in the fetus...
  10. Tapia H, Morano K. Hsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast. Mol Biol Cell. 2010;21:63-72 pubmed publisher
    ..We have discovered that Hsp90 and the cochaperone Sba1/p23 accumulate in the nucleus of quiescent Saccharomyces cerevisiae cells...
  11. Sahlström L, Sellström U, de Wit C, Lignell S, Darnerud P. Estimated intakes of brominated flame retardants via diet and dust compared to internal concentrations in a Swedish mother-toddler cohort. Int J Hyg Environ Health. 2015;218:422-32 pubmed publisher
    ..ethane (DBDPE), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP), bis(2,4,6-tribromophenoxy) ethane (BTBPE) and pentabromotoluene (PBT) for both mothers and toddlers...
  12. Zhao D, Han K, Huang X, Zhang L, Wang H, Liu N, et al. Screening and identification of B-cell epitopes within envelope protein of tembusu virus. Virol J. 2018;15:142 pubmed publisher
    ..Dot blot assay identified the peptides P21 (amino acids 301-329), P23 (amino acids 369-387), P27 (amino acids 464-471) and P28 (amino acids 482-496) as potential B-cell epitopes within ..
  13. Zhou B, Lu X, Tang Z, Liu D, Zhou Y, Zeng P, et al. Influence of sinomenine upon mesenchymal stem cells in osteoclastogenesis. Biomed Pharmacother. 2017;90:835-841 pubmed publisher
    ..25mM SIN can down-regulate the mRNA and protein expression levels of the Prostaglandin E synthase 3 (PTGES3) or PGE2 and RANKL, while the OPG was up-regulated...
  14. Olsen T, Panagopoulos I, Meling T, Micci F, Gorunova L, Thorsen J, et al. Fusion genes with ALK as recurrent partner in ependymoma-like gliomas: a new brain tumor entity?. Neuro Oncol. 2015;17:1365-73 pubmed publisher
    ..Both tumors harbored structural aberrations involving the ALK locus 2p23. Tumor 1 had an unbalanced t(2;14)(p23;q22) translocation which led to the fusion gene KTN1-ALK...
  15. Hansen D, Thiyagarajan T, Larson A, Hansen J. Telomerase repeat amplification protocol (TRAP) activity upon recombinant expression and purification of human telomerase in a bacterial system. Protein Expr Purif. 2016;123:6-13 pubmed publisher
    ..self-splicing hepatitis delta virus ribozyme, and the human heat shock complex of Hsp90, Hsp70, p60/Hop, Hsp40, and p23. The Hsp90 inhibitor geldanamycin did not affect post-assembly TRAP activity...
  16. Ooi W, Murayama Y, Mekler V, Minakhin L, Severinov K, Yokoyama S, et al. A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation. Nucleic Acids Res. 2017;: pubmed publisher
    RNA polymerase (RNAP) is a major target of gene regulation. Thermus thermophilus bacteriophage P23-45 encodes two RNAP binding proteins, gp39 and gp76, which shut off host gene transcription while allowing orderly transcription of phage ..
  17. Eachkoti R, Reddy M, Lieu Y, Cosenza S, Reddy E. Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140. Eur J Cancer. 2014;50:1982-92 pubmed publisher
    ..cells with ONO4140 is sufficient to inhibit the catalytic activity of Hsp90, evaluated through disruption of Hsp90-p23 association by immunoprecipitation...
  18. ÄŒechová E, Vojta Å, Kukučka P, Kočan A, Trnovec T, Murínová Ä, et al. Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health. Environ Int. 2017;108:137-145 pubmed publisher
    ..The Penta-BDE replacement, bis(2-ethylhexyl) tetrabromophthalate, BEH-TEBP, was present at the greatest concentrations of any of the AFRs and in some samples exceeded concentrations of BDE ..
  19. Tsai C, Lin Y, Chen Y, Feng C. Chemical derivatization combined with capillary LC or MALDI-TOF MS for trace determination of lipoic acid in cosmetics and integrated protein expression profiling in human keratinocytes. Talanta. 2014;130:347-55 pubmed publisher
    ..Protein identification was performed by simultaneous peptide sequencing and MASCOT search. The analysis revealed changes in several proteins, including CDC42, TPI1, HNRPA2B1, PRDX1, PTGES3 and MYL6.
  20. Nkabinde S, Okonkwo J, Olukunle O, Daso A. Determination of legacy and novel brominated flame retardants in dust from end of life office equipment and furniture from Pretoria, South Africa. Sci Total Environ. 2018;622-623:275-281 pubmed publisher
    ..However, Bis (2-ethylhexyl) tetrabromophthalate (BEH-TEBP) was only detected in 24% of the 21 samples exhibiting a concentration range of <LOD - 63ngg-1...
  21. Huang N, Wang C, Zhang N, Mao W, Liu B, Shen Y, et al. Effect of estrogen on prostaglandin synthetase in bovine oviduct smooth muscle. Eur J Pharmacol. 2018;818:287-293 pubmed publisher
    ..prostaglandin-endoperoxide synthase-1 (PTGS1), prostaglandin-endoperoxide synthase-2 (PTGS2), mPGES-1, mPGES-2, cPGES, and PGFS) by estradiol (E2) in bovine oviduct smooth muscle...
  22. Sugumaran A, Ponnusamy C, Kandasamy P, Krishnaswami V, Palanichamy R, Kandasamy R, et al. Development and evaluation of camptothecin loaded polymer stabilized nanoemulsion: Targeting potential in 4T1-breast tumour xenograft model. Eur J Pharm Sci. 2018;116:15-25 pubmed publisher
    ..pseudo-ternary phase diagrams, PSNEs were developed using capmul MCM:poloxamer 407 (4:1), solutol HS 15:simulsol P23 (1:2) and water. CPT polymer mixture was developed by solvent evaporation technique...
  23. Liepelt A, Naarmann de Vries I, Simons N, Eichelbaum K, Föhr S, Archer S, et al. Identification of RNA-binding Proteins in Macrophages by Interactome Capture. Mol Cell Proteomics. 2016;15:2699-714 pubmed publisher
    ..From this group, we validated the HSP90 cochaperone P23 that was demonstrated to exhibit cytosolic prostaglandin E2 synthase 3 (PTGES3) activity, and the hematopoietic cell-specific LYN substrate 1 (HCLS1 or HS1), a ..
  24. Lawrence K, Berry B, Handshoe J, HOUT D, Mazzola R, Morris S, et al. Detection of a TRAF1-ALK fusion in an anaplastic large cell lymphoma patient with chemotherapy and ALK inhibitor-resistant disease. BMC Res Notes. 2015;8:308 pubmed publisher
    ..kinase, which was first identified as the fusion partner of the nucleophosmin (NPM1) gene in the recurrent t(2;5)(p23;q35) found in a subset of anaplastic large cell lymphoma (ALCL)...
  25. Kim E, Seo Y, Park K, Kim S, Kim W. Overexpression of CaDSR6 increases tolerance to drought and salt stresses in transgenic Arabidopsis plants. Gene. 2014;552:146-54 pubmed publisher
    ..conserved in all plant DSR6 homologs identified and shared a sequence identity with the N-terminal regions of yeast p23(fyp) and human hTCTP, which contain Rab protein binding sites...
  26. Khan M, Majid A, Iqbal M, Majid A, Al Mansoub M, Haque R. Designing the angiogenic inhibitor for brain tumor via disruption of VEGF and IL17A expression. Eur J Pharm Sci. 2016;93:304-18 pubmed publisher
    ..55kcal/mol) and p23 (predicted binding: 12kj/mol, predicted efficiency: 0.17kcal/mol) chaperon proteins...
  27. Salazar S, Oliver C, Yáñez A, Avendaño Herrera R. Comparative analysis of innate immune responses to Streptococcus phocae strains in Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2016;51:97-103 pubmed publisher
    ..including two isolates from Atlantic salmon (LM-08-Sp and LM-13-Sp) and two from seal (ATCC 51973(T) and P23)...
  28. Gdula Argasińska J, Paśko P, Sułkowska Ziaja K, Kała K, Muszyńska B. Anti-inflammatory activities of garlic sprouts, a source of α-linolenic acid and 5-hydroxy-l-tryptophan, in RAW 264.7 cells. Acta Biochim Pol. 2017;64:551-559 pubmed publisher
    ..the garlic sprout extract were investigated by evaluating the cyclooxygenase-2 (COX-2), prostaglandin E synthase (cPGES), glutathione S transferase (GSTM1), nuclear factor NF-κB, peroxisome proliferator-activated receptors (PPARs), ..
  29. Silva N, Seraphim T, Minari K, Barbosa L, Borges J. Comparative studies of the low-resolution structure of two p23 co-chaperones for Hsp90 identified in Plasmodium falciparum genome. Int J Biol Macromol. 2018;108:193-204 pubmed publisher
    The p23 proteins are small acidic proteins that aid the functional cycle of the Hsp90 molecular chaperone...
  30. Zhang X, Verdine G. Mammalian DNA cytosine-5 methyltransferase interacts with p23 protein. FEBS Lett. 1996;392:179-83 pubmed
    ..Here we report an interaction between the C-terminal catalytic domain of the MTase and p23, a protein previously reported to associate with the progesterone receptor (PR) complex.
  31. Silva M, Hilton D, Furr J, Gray L, Preau J, Calafat A, et al. Quantification of tetrabromo benzoic acid and tetrabromo phthalic acid in rats exposed to the flame retardant Uniplex FPR-45. Arch Toxicol. 2016;90:551-7 pubmed publisher
    ..Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has increased...
  32. Zheng X, Xu F, Luo X, Mai B, Covaci A. Phosphate flame retardants and novel brominated flame retardants in home-produced eggs from an e-waste recycling region in China. Chemosphere. 2016;150:545-550 pubmed publisher
    ..NBFRs) (2-ethylhexyl-2,3,4,5-tetrabromo-benzoate (EH-TBB) and bis-(2-ethylhexyl)-3,4,5,6-tetrabromo-phthalate (BEH-TEBP)) were measured in free-range chicken eggs from three e-waste recycling sites and a negative control site located ..
  33. Thangaratnarajah C, Dinger K, Vohlen C, Klaudt C, Nawabi J, López García E, et al. Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction. Am J Physiol Lung Cell Mol Physiol. 2017;313:L491-L506 pubmed publisher
    ..in rats by isocaloric low-protein diet; lungs were analyzed on embryonic day (E) 21, postnatal day (P) 3, P12, and P23. Finally, primary neonatal lung myofibroblasts (pnF) and murine embryonic fibroblasts (MEF) were used to assess ..
  34. Schmidt J, Bonzheim I, Steinhilber J, Montes Mojarro I, Ortiz Hidalgo C, Klapper W, et al. EMMPRIN (CD147) is induced by C/EBPβ and is differentially expressed in ALK+ and ALK- anaplastic large-cell lymphoma. Lab Invest. 2017;97:1095-1102 pubmed publisher
    ..lymphoma (ALCL) is characterized by expression of oncogenic ALK fusion proteins due to the translocation t(2;5)(p23;q35) or variants...
  35. Wang J, Liu M, Zhang X, Yang G, Chen L. Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. Prostaglandins Other Lipid Mediat. 2017;134:1-6 pubmed publisher
    ..e. microsomal PGE2 synthase-1 (mPGES-1), mPGES-2 and cytosolic PGE2 synthase (cPGES)...
  36. Wang X, Cao X, Liu M, Zhang R, Zhang X, Gao Z, et al. Hsc70-2 is required for Beet black scorch virus infection through interaction with replication and capsid proteins. Sci Rep. 2018;8:4526 pubmed publisher
    ..protein 70 (Hsp70) family homolog, Hsc70-2, was co-purified with beet black scorch virus (BBSV) replication protein p23 and coat protein (CP), respectively...
  37. Scholz G, Cartledge K, Hall N. Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. J Biol Chem. 2001;276:30971-9 pubmed
    ..with Hsp90, Hsp70, p60Hop, immunophilins, and an unidentified p22 protein but not with the Hsp90 co-chaperone p23. Thus Harc likely represents a novel participant in Hsp90-mediated protein folding, potentially targeting Hsp90 to ..
  38. Sullivan W, Owen B, Toft D. The influence of ATP and p23 on the conformation of hsp90. J Biol Chem. 2002;277:45942-8 pubmed
    ..One co-chaperone, p23, binds to hsp90 only when hsp90 is in a conformation induced by the binding of ATP...
  39. Colombe L, Vindrios A, Michelet J, Bernard B. Prostaglandin metabolism in human hair follicle. Exp Dermatol. 2007;16:762-9 pubmed
    ..microsomal prostaglandin E synthase-1 (mPGES-1) and microsomal prostaglandin E synthase-2 (mPGES-2), cytosolic prostaglandin E synthase (cPGES), the aldoketoreductase AKR1C1 and the prostaglandin F synthase AKR1C3...
  40. Vogel S, Raulf N, Bregenhorn S, Biniossek M, Maurer U, Czabotar P, et al. Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?. J Biol Chem. 2012;287:9112-27 pubmed publisher
    ..purification by gel filtration and blue native gel electrophoresis, we detected only one protein, called p23 hsp90 co-chaperone, which consistently and specifically co-purified with Bax...
  41. Miao Y, Lin P, Wang W, Jeffrey Medeiros L, Lu X. CCND1-IGH Fusion-Amplification and MYC Copy Number Gain in a Case of Pleomorphic Variant Mantle Cell Lymphoma. Am J Clin Pathol. 2016;146:747-752 pubmed publisher
    ..3;q21), del(2)(p21), del(6)(p23), add(7)(p22),-9, del(9)(p22), add(11)(q13),-13, add(14)(p11...
  42. Liu W, Lyu R, Huang W, Li C, Liu H, Li J, et al. [Characteristics and Prognostic Significance of Cytogenetic Abnormalities in Diffuse Large B-Cell Lymphoma Patients with Bone Marrow Involvement]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:761-765 pubmed publisher
    ..decreasing order of incidence, were 1q+(17%), 1p+, 6q-, 8q+, 14q+, 18p+, 18q+ and aberrations involving band 2p21-p23 (6%,each)...
  43. Huang W, Li M, Jin X, Huang X, Zhao W, Tian X. Genetic profile and biological implication of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) in human cancers: an analysis using The Cancer Genome Atlas. Oncotarget. 2017;8:67241-67253 pubmed publisher
    ..In addition, we observed that PinX1 interacts with TERT, DKC1, PTGES3, and HSP90AA1...
  44. Ferrini F, Dering B, De Giorgio A, Lossi L, Granato A. Effects of Acute Alcohol Exposure on Layer 5 Pyramidal Neurons of Juvenile Mice. Cell Mol Neurobiol. 2018;38:955-963 pubmed publisher
    ..properties and cell viability of layer 5 pyramidal neurons from the somatosensory cortex of juvenile (P21-P23) C57BL/6N mice...
  45. Graumann K, Jungbauer A. Quantitative assessment of complex formation of nuclear-receptor accessory proteins. Biochem J. 2000;345 Pt 3:627-36 pubmed
    ..The interaction kinetics and dynamics of hsp90, hsp70, p60 (Hop), FKBP52, FKBP51, p48 (Hip) and p23 have been assessed by a biosensor approach measuring the complex formation in real time...
  46. Walsh J, Cullen S, Sheridan C, Lüthi A, Gerner C, Martin S. Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A. 2008;105:12815-9 pubmed publisher
    ..differential activity toward multiple substrate proteins, including Bid, XIAP, gelsolin, caspase-6, and cochaperone p23. Caspase-3 was found to be generally more promiscuous than caspase-7 and appears to be the major executioner ..
  47. Nguyen P, Wang D, Wang Y, Li Y, Uchizono J, Chan W. p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines. Biochem Pharmacol. 2012;84:838-50 pubmed publisher
    ..Without ligand, the AhR complex is cytoplasmic and contains p23. Our objective was to investigate whether the wild type p23 levels are important for the AhR function...
  48. Lepvrier E, Nigen M, Moullintraffort L, Chat S, Allegro D, Barbier P, et al. Hsp90 oligomerization process: How can p23 drive the chaperone machineries?. Biochim Biophys Acta. 2015;1854:1412-24 pubmed publisher
    ..matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we studied the interaction of p23 with both Hsp90 dimer and oligomers...
  49. Olukunle O, Okonkwo O. Concentration of novel brominated flame retardants and HBCD in leachates and sediments from selected municipal solid waste landfill sites in Gauteng Province, South Africa. Waste Manag. 2015;43:300-6 pubmed publisher
    ..ethane (BTBPE), decabromodiphenyl ethane (DBDPE), bis(2-ethylhexyl)-3,4,5,6-tetrabromo-phthalate (BEH-TEBP) and hexabromocyclododecane (HBCD)...
  50. Liu S, Jemiolo B, Lavin K, Lester B, Trappe S, Trappe T. Prostaglandin E2/cyclooxygenase pathway in human skeletal muscle: influence of muscle fiber type and age. J Appl Physiol (1985). 2016;120:546-51 pubmed publisher
    ..PGE2/COX pathway proteins [COX enzymes (COX-1 and COX-2), PGE2 synthases (cPGES, mPGES-1, and mPGES-2), and PGE2 receptors (EP1, EP2, EP3, and EP4)] were quantified via Western blot...
  51. Schlegel V, Thieme M, Holzmann C, Witt M, Grittner U, Rolfs A, et al. Pharmacologic Treatment Assigned for Niemann Pick Type C1 Disease Partly Changes Behavioral Traits in Wild-Type Mice. Int J Mol Sci. 2016;17: pubmed
    ..Miglustat injections were performed daily from P10 till P23. Starting at P23, miglustat was embedded in the chow. Other mice were treated with miglustat only, or sham-treated...
  52. Zou J, Guo Y, Guettouche T, Smith D, Voellmy R. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell. 1998;94:471-80 pubmed
    ..Reduction of the level of Hsp90 but not of Hsp/c70, Hop, Hip, p23, CyP40, or Hsp40 dramatically activates HSF1...
  53. Forsythe H, Jarvis J, Turner J, Elmore L, Holt S. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem. 2001;276:15571-4 pubmed
    ..We have previously found two additional components of the telomerase holoenzyme, the chaperones p23 and heat shock protein (hsp) 90, both of which are required for efficient telomerase assembly in vitro and in vivo...
  54. El Kasaby A, Koban F, Sitte H, Freissmuth M, Sucic S. A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter. J Biol Chem. 2014;289:28987-9000 pubmed publisher
    ..These findings support the concept that the folding trajectory of SERT is sampled by a cytoplasmic chaperone relay. ..
  55. Patel N, Crider A, Pandya C, Ahmed A, Pillai A. Altered mRNA Levels of Glucocorticoid Receptor, Mineralocorticoid Receptor, and Co-Chaperones (FKBP5 and PTGES3) in the Middle Frontal Gyrus of Autism Spectrum Disorder Subjects. Mol Neurobiol. 2016;53:2090-9 pubmed publisher
    ..levels of GR isoforms (GRα, GRβ, GRγ, and GRP), mineralocorticoid receptor (MR), GR co-chaperones (FKBP5, PTGES3, and BAG1), and inflammatory cytokines (IL-6, IL-1β, and IFN-γ) were examined in the postmortem middle ..
  56. He W, Zheng X, Zhang Y, Gao Y, Song A, van der Goot F, et al. Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone. PLoS ONE. 2016;11:e0147515 pubmed publisher
    ..USP19_b directly interacts with HSP90 through its N-terminal CS (CHORD and SGT1)/P23 domains...
  57. Muszyńska B, Łojewski M, Sułkowska Ziaja K, Szewczyk A, Gdula Argasińska J, Hałaszuk P. In vitro cultures of Bacopa monnieri and an analysis of selected groups of biologically active metabolites in their biomass. Pharm Biol. 2016;54:2443-2453 pubmed
    ..Anti-inflammatory effect of B. monnieri extracts was evaluated in the A549 cells. COX-2 and cPGES expression was analyzed using Western blots...
  58. Sternbæk L, Draborg A, Nielsen C, Jacobsen S, Iversen L, Troelsen L, et al. Efficient evaluation of humoral immune responses by the use of serum pools. J Immunol Methods. 2017;443:1-8 pubmed publisher
    ..The presence of Epstein-Barr virus (EBV) EA/D-, EBNA-1-, VCA p23-, and gp350-directed antibodies was used to validate serum pools as an efficient tool for further investigations by ..
  59. Knoblauch R, Garabedian M. Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction. Mol Cell Biol. 1999;19:3748-59 pubmed
    ..steroid receptors, is complexed with Hsp90 and other molecular chaperone components, including an immunophilin, and p23. This Hsp90-based chaperone complex is thought to repress the ER's transcriptional regulatory activities while ..
  60. Butt C, Miranda M, Stapleton H. Development of an analytical method to quantify PBDEs, OH-BDEs, HBCDs, 2,4,6-TBP, EH-TBB, and BEH-TEBP in human serum. Anal Bioanal Chem. 2016;408:2449-59 pubmed publisher
    ..Today, novel FRs such as Firemaster® 550, a mixture that contains two brominated compounds, EH-TBB and BEH-TEBP are used as replacements for PBDEs in some applications, and there is a need to develop a comprehensive analytical ..
  61. Papadopoulou Z, Papoulidis I, Sifakis S, Markopoulos G, Vetro A, Vlaikou A, et al. Partial monosomy 8p and trisomy 16q in two children with developmental delay detected by array comparative genomic hybridization. Mol Med Rep. 2017;16:8808-8818 pubmed publisher
    ..of liveborn unrelated children with developmental delay and overlapping unbalanced translocations der(8)t(8;16)(p23.2;q23.3) and der (8)t(8;16)(p23.1;q23...
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    The co-chaperone p23 forms a complex with the chaperone Hsp90 that mediates the folding pathway leading to the production of functional steroid receptors...
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    ..Together these findings suggest that the HSP90 interactome is dynamic with respect to nucleotide and drug ligands and that pharmacological inhibition of HSP90 may stimulate the formation of specific complexes. ..
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    ..EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), bis(2-ethylhexyl)-3,4,5,6-tetrabromo-phthalate (BEH-TEBP) and decabromodiphenyl ethane (DBDPE)...
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    ..b>p23, an essential component of the apo-AR complex, acts also after ligand binding to increase AR transcriptional ..
  67. Yin J, Xia W, Li Y, Guo C, Zhang Y, Huang S, et al. COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells. Am J Transl Res. 2017;9:3967-3976 pubmed
    ..At the same time, we observed a dose-dependent upregulation of another two PGE2 synthases of mPGES-2 and cPGES determined by qRT-PCR...
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    ..we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (cPGES), a terminal enzyme of the cyclooxygenase (COX)-1-mediated PGE(2) biosynthetic pathway...
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    The Hsp90-associated protein p23 modulates Hsp90 activity during the final stages of the chaperone pathway to facilitate maturation of client proteins...
  70. Echtenkamp F, Gvozdenov Z, Adkins N, Zhang Y, Lynch Day M, Watanabe S, et al. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler. Mol Cell. 2016;64:888-899 pubmed publisher
    ..The significance of these connections is poorly understood. To delineate why Hsp90 and its cochaperone p23 interact with a mature structure, we focused on the RSC chromatin remodeler...
  71. Skalova A, Stenman G, Simpson R, Hellquist H, Slouka D, Svoboda T, et al. The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas. Am J Surg Pathol. 2017;: pubmed publisher
    ..A t(6;9)(q22-23;p23-34) translocation resulting in a MYB-NFIB gene fusion has been identified in the majority of adenoid cystic ..
  72. Kumar S, Connor J, Dodds R, Halsey W, Van Horn M, Mao J, et al. Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. Osteoarthritis Cartilage. 2001;9:641-53 pubmed
    ..Further analysis of genes identified from these libraries may provide molecular targets for diagnosis and/or treatment of osteoarthritis (OA). ..
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    ..These findings revealed that cytosolic prostaglandin E(2) synthases is found in microglia, neurons, and endothelium of control human middle frontal gyrus and that its levels decrease in pyramidal cells of Alzheimer's disease brains. ..
  74. Simpson N, Gertz J, Imberg K, Myers R, Garabedian M. Research resource: enhanced genome-wide occupancy of estrogen receptor ? by the cochaperone p23 in breast cancer cells. Mol Endocrinol. 2012;26:194-202 pubmed publisher
    b>p23 is a chaperone with multiple heat shock protein 90 dependent and independent cellular functions, including stabilizing unliganded steroid receptors and modulating receptor-DNA dynamics...
  75. Sun L, Prince T, Manjarrez J, Scroggins B, Matts R. Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012;1823:1092-101 pubmed publisher
    ..Complexes formed by Aha1 with Hsp90 in RRL were stabilized by molybdate and contained the co-chaperones FKBP52 and p23/Sba1, but lacked HOP/Sti1 and Cdc37...
  76. Bartsch K, Hombach Barrigah A, Clos J. Hsp90 inhibitors radicicol and geldanamycin have opposing effects on Leishmania Aha1-dependent proliferation. Cell Stress Chaperones. 2017;22:729-742 pubmed publisher
    ..Activity of Hsp90 is regulated by co-chaperones of the Aha1 and P23 families. In this paper, we studied the expression of L...
  77. Kazlauskas A, Sundstrom S, Poellinger L, Pongratz I. The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Mol Cell Biol. 2001;21:2594-607 pubmed
    The molecular chaperone complex hsp90-p23 interacts with the dioxin receptor, a ligand-dependent basic helix-loop-helix (bHLH)/Per-Arnt-Sim domain transcription factor...
  78. Han R, Tsui S, Smith T. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression. J Biol Chem. 2002;277:16355-64 pubmed
    ..b>cPGES is cytoplasmic, apparently identical to the hsp90 chaperone, p23, and associates functionally with prostaglandin-..
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    Heat shock protein 90 alpha (Hsp90 alpha)/p23 and Hsp90 beta/p23 interactions are crucial for proper folding of proteins involved in cancer and neurodegenerative diseases...
  80. Lee J, Chung I. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 2010;290:76-86 pubmed publisher
    The molecular chaperone complex Hsp90-p23 interacts with the rate-limiting catalytic subunit of telomerase, hTERT...
  81. Sinclair D, Fillman S, Webster M, Weickert C. Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness. Sci Rep. 2013;3:3539 pubmed publisher
    ..totaling 55 schizophrenia, 34 bipolar disorder and 55 control individuals, we identified increased FKBP5 and PTGES3 mRNA expression, and decreased BAG1 mRNA expression, in the prefrontal cortex in schizophrenia cases relative to ..
  82. Holt S, Aisner D, Baur J, Tesmer V, Dy M, Ouellette M, et al. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 1999;13:817-26 pubmed
    ..We have identified the molecular chaperones p23 and Hsp90 as proteins that bind to the catalytic subunit of telomerase...
  83. McLaughlin S, Smith H, Jackson S. Stimulation of the weak ATPase activity of human hsp90 by a client protein. J Mol Biol. 2002;315:787-98 pubmed
    ..proteins, respectively), as well as high molecular mass immunophilins, such as FKBP59, and the small acidic protein p23. The role of these proteins in Hsp90-mediated assembly processes is poorly understood...
  84. Meadows J, Eis A, Brockman D, Myatt L. Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor. J Clin Endocrinol Metab. 2003;88:433-9 pubmed
    ..Cytosolic PGES (cPGES) is identical to the heat shock protein 90 chaperone, p23, and is reportedly functionally coupled to constitutive ..
  85. Cullen S, Adrain C, Lüthi A, Duriez P, Martin S. Human and murine granzyme B exhibit divergent substrate preferences. J Cell Biol. 2007;176:435-44 pubmed
    ..These data demonstrate that human and murine GzmB are distinct enzymes with different substrate preferences. Our observations also illustrate how subtle differences in enzyme structure can radically affect substrate selection. ..
  86. Ge X, Rameix Welti M, Gault E, Chase G, Dos Santos Afonso E, Picard D, et al. Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response. PLoS ONE. 2011;6:e23368 pubmed publisher
    ..Here we report that the p23 cochaperone of Hsp90, which plays a major role in glucocorticoid receptor folding and function, associates with ..
  87. Boucher D, Blais V, Denault J. Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis. Proc Natl Acad Sci U S A. 2012;109:5669-74 pubmed publisher
    ..sequence preference as caspase-3, is better at cleaving poly(ADP ribose) polymerase 1 (PARP) and Hsp90 cochaperone p23, despite a lower intrinsic activity...
  88. Liu X, Zou L, Zhu L, Zhang H, Du C, Li Z, et al. miRNA mediated up-regulation of cochaperone p23 acts as an anti-apoptotic factor in childhood acute lymphoblastic leukemia. Leuk Res. 2012;36:1098-104 pubmed publisher
    b>p23 is a heat shock protein 90 (Hsp90) cochaperone that plays a significant role in estrogen receptor (ER) alpha signal transduction and telomerase activity; it is up-regulated in several cancers...
  89. Shimamura T, Perera S, Foley K, Sang J, Rodig S, Inoue T, et al. Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin Cancer Res. 2012;18:4973-85 pubmed publisher
    ..We describe the anticancer activity of ganetespib, a novel non-geldanamycin heat shock protein 90 (HSP90) inhibitor, in non-small cell lung cancer (NSCLC) models...
  90. Pare J, LaPointe P, Hobman T. Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells. Mol Biol Cell. 2013;24:2303-10 pubmed publisher
    ..Here we show that the Hsp90 cochaperones Cdc37, Aha1, FKBP4, and p23 are required for efficient RNAi...
  91. Chen T, Keeney M, Chintakuntlawar A, Knutson D, Kloft Nelson S, Greipp P, et al. Adenoid cystic carcinoma of the lacrimal gland is frequently characterized by MYB rearrangement. Eye (Lond). 2017;31:720-725 pubmed publisher
    ..is frequently characterized by a fusion transcript involving genes MYB and NFIB; more specifically, t(6;9)(q22-23;p23-24)...
  92. Oxelmark E, Roth J, Brooks P, Braunstein S, Schneider R, Garabedian M. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol. 2006;26:5205-13 pubmed
    The cochaperone p23 plays an important role in estrogen receptor alpha (ER) signal transduction. In this study, we investigated how p23 regulates ER target gene activation and affects tumor growth and progression...