PTGES3

Summary

Gene Symbol: PTGES3
Description: prostaglandin E synthase 3
Alias: P23, TEBP, cPGES, prostaglandin E synthase 3, Hsp90 co-chaperone, cytosolic prostaglandin E synthase, cytosolic prostaglandin E2 synthase, progesterone receptor complex p23, prostaglandin E synthase 3 (cytosolic), telomerase-binding protein p23, unactive progesterone receptor, 23 kD
Species: human

Top Publications

  1. pmc Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes
    J L Johnson
    Department of Biochemistry and Molecular Biology, Mayo Graduate School, Rochester, Minnesota 55905
    Mol Cell Biol 14:1956-63. 1994
  2. ncbi Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation
    K D Dittmar
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:13047-54. 1997
  3. pmc In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
    W M Obermann
    Department of Cellular Biochemistry, Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    J Cell Biol 143:901-10. 1998
  4. ncbi The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor
    A Kazlauskas
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Biol Chem 275:41317-24. 2000
  5. ncbi Disassembly of transcriptional regulatory complexes by molecular chaperones
    Brian C Freeman
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Science 296:2232-5. 2002
  6. pmc Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
    Alexander Brychzy
    Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 22:3613-23. 2003
  7. ncbi The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex
    Yoshihiro Morishima
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:48754-63. 2003
  8. ncbi Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90
    Gabriela M Wochnik
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    FEBS Lett 560:35-8. 2004
  9. ncbi The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins
    Stephen H McLaughlin
    Cambridge University, Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Biol 356:746-58. 2006
  10. pmc FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells
    Li Ni
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 30:1243-53. 2010

Research Grants

  1. Dynamics of Transcriptional Regulation
    Elena Zelin; Fiscal Year: 2011
  2. Dynamic signaling by intracellular hormone receptors
    Brian C Freeman; Fiscal Year: 2010
  3. Ahmed Chadli; Fiscal Year: 2014
  4. The Role of NPM-ALK Signaling in Tumor Cell Metabolism
    SCOTT RP MCDONNELL; Fiscal Year: 2012
  5. Brian C Freeman; Fiscal Year: 2015
  6. Gene Expression in Rat Cochlea Following Loss of Hair Cells
    Erin Bailey; Fiscal Year: 2013
  7. Proteomic biomarkers of ALK+ lymphoma
    Megan S Lim; Fiscal Year: 2013
  8. c-Myb fusion proteins in Adenoid Cystic Carcinoma
    Timothy P Bender; Fiscal Year: 2012
  9. Sanjiv S Gambhir; Fiscal Year: 2016
  10. Chaperone-mediated signaling in Alzheimer's disease
    Chad A Dickey; Fiscal Year: 2010

Detail Information

Publications310 found, 100 shown here

  1. pmc Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes
    J L Johnson
    Department of Biochemistry and Molecular Biology, Mayo Graduate School, Rochester, Minnesota 55905
    Mol Cell Biol 14:1956-63. 1994
    ..progesterone receptor results in the copurification of hsp90, hsp70, and three additional proteins, p54, p50, and p23. p23 is also present in immunoaffinity-purified hsp90 complexes along with hsp70 and another protein, p60...
  2. ncbi Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation
    K D Dittmar
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:13047-54. 1997
    ..hsp90 heterocomplex assembly system with purified rabbit hsp90 and hsp70 and bacterially expressed human p23 and p60 (Dittmar, K. D., Hutchison, K. A., Owens-Grillo, J. K., and Pratt, W. B. (1996) J. Biol. Chem...
  3. pmc In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
    W M Obermann
    Department of Cellular Biochemistry, Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    J Cell Biol 143:901-10. 1998
    ..mutant Hsp90 proteins tested are defective in the binding and ATP hydrolysis-dependent cycling of the co-chaperone p23, which is thought to regulate the binding and release of substrate polypeptide from Hsp90...
  4. ncbi The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor
    A Kazlauskas
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Biol Chem 275:41317-24. 2000
    ..The nonactivated form of the dioxin receptor is associated with heat shock protein (hsp) 90, the co-chaperone p23, and the immunophilin-like protein XAP2...
  5. ncbi Disassembly of transcriptional regulatory complexes by molecular chaperones
    Brian C Freeman
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Science 296:2232-5. 2002
    ..Here, we show that the p23 molecular chaperone localizes in vivo to genomic response elements in a hormone-dependent manner, disrupting ..
  6. pmc Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
    Alexander Brychzy
    Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 22:3613-23. 2003
    ..We propose a novel mechanism in which Tpr2 mediates the retrograde transfer of substrates from Hsp90 onto Hsp70. At normal levels substoichiometric to Hsp90 and Hsp70, this activity optimizes the function of the multichaperone machinery...
  7. ncbi The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex
    Yoshihiro Morishima
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:48754-63. 2003
    ..by a multiprotein machinery, including hsp90 and hsp70 as essential and abundant components and Hop, hsp40, and p23 as non-essential cochaperones that are present in much lower abundance in cells...
  8. ncbi Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90
    Gabriela M Wochnik
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    FEBS Lett 560:35-8. 2004
    b>p23 is a regulatory co-chaperone of heat shock protein (Hsp) 90, but can also act as a general molecular chaperone by itself...
  9. ncbi The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins
    Stephen H McLaughlin
    Cambridge University, Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Biol 356:746-58. 2006
    ..Here, we have examined the inhibition of the ATPase activity of human Hsp90beta by one such co-chaperone, human p23. We demonstrate that human p23 interacts with Hsp90 in both the absence and presence of nucleotide with a higher ..
  10. pmc FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells
    Li Ni
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 30:1243-53. 2010
    ..Using recombinant proteins, we show that FKBP51 stimulates recruitment of the cochaperone p23 to the ATP-bound form of Hsp90, forming an FKBP51-Hsp90-p23 superchaperone complex...
  11. pmc N-terminal domain of human Hsp90 triggers binding to the cochaperone p23
    G Elif Karagöz
    Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 108:580-5. 2011
    ..by NMR spectroscopy in solution, and we elucidated the mechanism of the inhibition of its ATPase by its cochaperone p23. We assigned isoleucine side chains of Hsp90 via specific isotope labeling of their δ-methyl groups, which allowed ..
  12. pmc A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor
    S C Nair
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198, USA
    Cell Stress Chaperones 1:237-50. 1996
    ..These proteins are Hsp90, Hsp70, Hip, p60, p23, FKBP51, FKBP52 and Cyp40...
  13. ncbi Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70
    K D Dittmar
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:21213-20. 1997
    ..hsp90 assembly system containing four required components, hsp90, hsp70, p60, and p23 (Dittmar, K. D., Hutchison, K. A., Owens-Grillo, J. K., and Pratt, W. B. (1996) J. Biol. Chem. 271, 12833-12839)...
  14. ncbi Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis
    T Tanioka
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Biol Chem 275:32775-82. 2000
    ..we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (cPGES), a terminal enzyme of the cyclooxygenase (COX)-1-mediated PGE(2) biosynthetic pathway...
  15. ncbi The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas
    Simo Mattila
    Department of Neurosurgery, Oulu University Hospital, Oulu, Finland
    Neuropathology 29:156-65. 2009
    ..The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES convert PGH2 into prostaglandin E2...
  16. ncbi Involvement of non-NMDA receptors in the rescue of weaver cerebellar granule neurons and sensitivity to ethanol of cerebellar AMPA receptors in oocytes
    B E Akinshola
    Department of Pharmacology, Howard University College of Medicine, Suite 3408 NPG Adams Bldg, 520 W Street N W, Washington, DC 20059, USA
    Brain Res Mol Brain Res 93:8-17. 2001
    ..injection of mRNA isolated from cerebella of normal and weaver P5-6, postnatal day 10 (P10) and postnatal day 23 (P23) mice; and (5) ethanol, which at low 1-10 mM concentrations had been shown previously to rescue homozygous weaver ..
  17. ncbi Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia
    Wolfgang Knecht
    Molecular Pharmacology and Lead Generation, AstraZeneca Research and Development, Mölndal 431 83, Sweden
    J Biol Chem 282:26089-100. 2007
    ..We examined the biological actions of human trypsin IV (or mesotrypsin) and rat p23, inhibitor-resistant forms of trypsin...
  18. doi Citrus tristeza virus: a pathogen that changed the course of the citrus industry
    Pedro Moreno
    Instituto Valenciano de Investigaciones Agrarias, Cra Moncada Náquera Km 4 5, Moncada, 46113 Valencia, Spain
    Mol Plant Pathol 9:251-68. 2008
    ..p6, p65, p61, p27 and p25), asymmetrical accumulation of positive and negative strands during RNA replication (p23), or suppression of post-transcriptional gene silencing (p25, p20 and p23), with the role of proteins p33, p18 and ..
  19. ncbi Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A
    M Milad
    Department of Biochemistry and Molecular Biology, Mayo Medical School, Rochester, Minnesota 55905, USA
    Mol Endocrinol 9:838-47. 1995
    ..molecular masses of 54-kDa and 23-kDa and have been shown by Western blotting to be related to the proteins p54 and p23 that are associated with chicken PR...
  20. ncbi Detection of a subset of CD30+ anaplastic large cell lymphoma by interphase fluorescence in situ hybridization
    Hyung Ju C Shin
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Diagn Cytopathol 29:61-6. 2003
    ..The t(2;5)(p23;q35) has been identified in a subset of T/null-ALCL and is known to be associated with a favorable prognosis...
  21. pmc Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis
    Graeme S Cottrell
    Center for the Neurobiology of Digestive Disease, Department of Surgery, University of California, San Francisco, San Francisco, California 94143 0660, USA
    Gastroenterology 132:2422-37. 2007
    ..We studied the role of protease-activated receptor 2 (PAR(2)) and its activating enzymes, trypsins and tryptase, in Clostridium difficile toxin A (TxA)-induced enteritis...
  22. pmc Serine proteases mediate inflammatory pain in acute pancreatitis
    Eugene P Ceppa
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1033-42. 2011
    ..We hypothesized that human trypsin IV and rat P23, which activate PAR(2) and are resistant to pancreatic trypsin inhibitors, contribute to pancreatic inflammation ..
  23. ncbi The human dendritic cell marker CD83 maps to chromosome 6p23
    S Berchtold
    Department of Dermatology, , Germany
    Ann Hum Genet 63:181-3. 1999
    ..2. Finally, using FISH analysis the CD83 gene was localized to chromosome 6 band p23.
  24. ncbi Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin
    A M Silverstein
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:16224-30. 1997
    Steroid receptors are recovered from hormone-free cells in multiprotein complexes containing hsp90, p23, an immunophilin, and often some hsp70...
  25. ncbi Hypotensive action of an aqueous extract of Pimenta dioica (Myrtaceae) in rats
    A Suarez
    Departamento de Fisiologia, Escuela de Medicina, Universidad de Costa Rica, Costa Rica
    Rev Biol Trop 48:53-8. 2000
    ..The arterial line was connected to a pressure transducer (Viggo-Spectramed model P23 XL) and a polygraph (Grass model 7H) and monitored continuously during the first five minutes after plant extract ..
  26. ncbi Prenatal detection of complex chromosomal aberrations using advanced molecular cytogenetic techniques
    J M de Pater
    Department of Biomedical Genetics, University Medical Centre, Utrecht, The Netherlands
    Prenat Diagn 23:747-51. 2003
    ..This study aimed to identify a marker chromosome and characterize the short arm of a derivative chromosome 5 in a foetus with the following karyotype: mos 47,XX,del(5)(p?),+i(5)(p10)[50]/48,XX,del(5)(p?),+i(5)(p10),+mar[25]...
  27. ncbi Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90
    Didier Picard
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Exp Cell Res 312:198-204. 2006
    b>p23 is a component of the Hsp90 molecular chaperone machine. It binds and stabilizes the ATP-bound dimeric form of Hsp90...
  28. pmc Role of immunoglobulin A monoclonal antibodies against P23 in controlling murine Cryptosporidium parvum infection
    F J Enriquez
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, Arizona 85721, USA
    Infect Immun 66:4469-73. 1998
    ..The Ag recognized comigrated in sodium dodecyl sulfate-polyacrylamide gel electrophoresis with P23, a previously defined neutralization-sensitive zoite pellicle Ag...
  29. ncbi Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1
    Marco Wachtel
    University Children s Hospital, Division of Oncology, Zurich, Switzerland
    Cancer Res 64:5539-45. 2004
    ..as belonging to the translocation-positive group, leading to the identification of a novel translocation t(2;2)(q35;p23), which generates a fusion protein composed of PAX3 and the nuclear receptor coactivator NCOA1, having similar ..
  30. pmc Genome comparison and proteomic characterization of Thermus thermophilus bacteriophages P23-45 and P74-26: siphoviruses with triplex-forming sequences and the longest known tails
    Leonid Minakhin
    Waksman Institute for Microbiology, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    J Mol Biol 378:468-80. 2008
    ..lytic Thermus thermophilus siphoviruses with exceptionally long (approximately 800 nm) tails, bacteriophages P23-45 and P74-26, were sequenced completely...
  31. ncbi Genetic heterogeneity in a prostatic carcinoma and associated prostatic intraepithelial neoplasia as demonstrated by combined use of laser-microdissection, degenerate oligonucleotide primed PCR and comparative genomic hybridization
    H Zitzelsberger
    GSF National Research Center for Environment and Health, Institute of Radiobiology, Neuherberg, Germany
    Virchows Arch 433:297-304. 1998
    ..changes were found in only one of the microdissected areas (gains on 16q21-->q23, 20q22 and losses on 8p21-->p23, 12p11-->q12, 12q21-->q26, 13q21-->q34, 16q12, and 18q22)...
  32. pmc The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells
    B Maes
    Division of Morphology and Molecular Pathology, Catholic University Leuven, Leuven, Belgium
    Am J Pathol 158:2185-93. 2001
    Anaplastic large cell lymphoma (ALCL) is frequently associated with the t(2;5)(p23;q35) translocation. It creates a NPM-ALK fusion gene, fusing the anaplastic lymphoma kinase (ALK) gene (2p23) and the nucleophosmin (NPM) gene (5q35)...
  33. ncbi High-level expression of BCL3 differentiates t(2;5)(p23;q35)-positive anaplastic large cell lymphoma from Hodgkin disease
    Momoko Nishikori
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
    Blood 101:2789-96. 2003
    Anaplastic large cell lymphoma (ALCL) with t(2;5)(p23;q35) and Hodgkin disease (HD) share many cellular features, including expression of CD30...
  34. pmc Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus
    Ming Jen Lee
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 4:e7868. 2009
    ..Normal-pressure hydrocephalus (NPH) is a neurodegenerative disorder that usually occurs late in adult life. Clinically, the cardinal features include gait disturbances, urinary incontinence, and cognitive decline...
  35. ncbi The 23-kDa acidic protein in reticulocyte lysate is the weakly bound component of the hsp foldosome that is required for assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90
    K A Hutchison
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 270:18841-7. 1995
    ..Immunoadsorption of the Centricon C-100 filtrate with a monoclonal antibody against p23 eliminates its ability to stimulate the wheat germ heterocomplex assembly/receptor folding system, and the activity ..
  36. ncbi The role of DnaJ-like proteins in glucocorticoid receptor.hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex
    K D Dittmar
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:7358-66. 1998
    ..hsp90 heterocomplex assembly system with purified rabbit hsp90 and hsp70 and bacterially expressed human p23 and p60. We have shown that hsp90, p60, and hsp70 form an hsp90.p60...
  37. ncbi Lack of correlation between bronchial late allergic reaction to Dermatophagoides pteronyssinus and in vitro immunoglobulin E reactivity to histamine-releasing factor derived from mononuclear cells
    Ilona Kleine Budde
    Department of Immunopathology, Sanquin Research at CLB, Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, The Netherlands
    Ann Allergy Asthma Immunol 89:606-12. 2002
    ..Sera capable of passively sensitizing basophils to release histamine to HRF were designated IgE+ sera. IgE+ and HRF have been suggested to play a role in late allergic reaction (LAR)...
  38. pmc A new role for ns polyprotein cleavage in Sindbis virus replication
    Rodion Gorchakov
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1019, USA
    J Virol 82:6218-31. 2008
    ..The following processing steps make nsP1+P23+nsP4, and later nsP1+nsP2+nsP3+nsP4...
  39. pmc Genetic reconstitution of the human adenovirus type 2 temperature-sensitive 1 mutant defective in endosomal escape
    Nicola Imelli
    Institute of Zoology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Virol J 6:174. 2009
    ..Ad2-ts1 fails to package the viral protease L3/p23, and Ad2-ts1 virions do not efficiently escape from endosomes...
  40. pmc Complex and segmental uniparental disomy (UPD): review and lessons from rare chromosomal complements
    D Kotzot
    Institut fur Humangenetik, Technische Universitat Munchen, Trogerstrasse 32, D 81675 Munchen, Germany
    J Med Genet 38:497-507. 2001
    ..To review all cases with segmental and/or complex uniparental disomy (UPD), to study aetiology and mechanisms of formation, and to draw conclusions...
  41. doi Complex and segmental uniparental disomy updated
    D Kotzot
    Division of Clinical Genetics, Department of Medical Genetics, Molecular and Clinical Pharmacology, Schoepfstr 41, A 6020 Innsbruck, Austria
    J Med Genet 45:545-56. 2008
    ..To review all cases with segmental and/or complex uniparental disomy (UPD) and to discuss the impact of these cases on medical genetics...
  42. ncbi Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma
    R D Gascoyne
    Departments of Pathology and Laboratory Medicine, Medical Oncology, and Epidemiology, British Columbia Cancer Agency, University of British Columbia, Vancouver, BC, Canada
    Blood 93:3913-21. 1999
    Anaplastic large cell lymphoma (ALCL) is an aggressive lymphoma that is frequently associated with the t(2;5)(p23;q35), resulting in expression of a fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which can be ..
  43. ncbi Expression and characterization of the catalytic subunit of telomerase in normal and cataractous canine lens epithelial cells
    Carmen Maria Helena Colitz
    Department of Veterinary Clinical Science, The Ohio State University, Columbus, OH, USA
    Mol Vis 12:1067-76. 2006
    ..Finally, the expression of p23 and heat shock protein 90 (hsp90), coactivators of TERT in neoplastic cells, were evaluated in normal and ..
  44. pmc Development of a swine-specific fecal pollution marker based on host differences in methanogen mcrA genes
    Jennifer A Ufnar
    Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive, 5018, Hattiesburg, MS 39406 0001, USA
    Appl Environ Microbiol 73:5209-17. 2007
    ..Only one mcrA sequence (P23-2) showed specificity for swine and therefore was used for environmental testing...
  45. pmc Localization of the gene causing keratolytic winter erythema to chromosome 8p22-p23, and evidence for a founder effect in South African Afrikaans-speakers
    M Starfield
    Department of Human Genetics, School of Pathology, South African Institute for Medical Research and University of the Witwatersrand, Johannesburg
    Am J Hum Genet 61:370-8. 1997
    ..Linkage to the microsatellite marker D8S550 on chromosome 8p22-p23 was initially observed, with a maximum LOD score (Z(max)) of 9...
  46. ncbi Mice immunised with synthetic peptide from N-terminal conserved region of merozoite surface antigen-2 of human malaria parasite Plasmodium falciparum can control infection induced by Plasmodium yoelii yoelii 265BY strain
    A A Lougovskoi
    International Centre for Genetic Engineering and Biotechnology, PO Box 10504, Aruna Asaf Ali Marg, New Delhi, India
    Vaccine 18:920-30. 1999
    ..Co-linear synthesis of SNTFINNA-epitope in tandem with the entire N-terminal conserved region peptide (P23) made this construct, namely P8...
  47. ncbi Response of T lymphocytes from previously infected calves to recombinant Cryptosporidium parvum P23 vaccine antigen
    C R Wyatt
    Department of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan 66506, USA
    J Parasitol 91:1239-42. 2005
    ..expression in lamina propria lymphocytes accompanied by IgG2 subclass fecal antibodies to Cryptosporidium parvum p23 emerged in gut mucosa of calves recovering from cryptosporidiosis...
  48. ncbi TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    Huawei Xin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 445:559-62. 2007
    ..In Oxytricha nova, telomere G-overhangs are protected by the TEBP-alpha/beta heterodimer...
  49. doi Hyperactivated STAT3 in ALK-positive diffuse large B-cell lymphoma with clathrin-ALK fusion
    Shuji Momose
    Department of Pathology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350 8550, Japan
    Hum Pathol 40:75-82. 2009
    ..similar to ALK-positive anaplastic large cell lymphoma, most reported cases are characterized by t(2;17)(p23;q23) involving the clathrin gene. Here, we report 2 cases of ALK-positive DLBCL...
  50. ncbi The p24 family member p23 is required for early embryonic development
    A Denzel
    Imperial Cancer Research Fund, London, UK
    Curr Biol 10:55-8. 2000
    ..physiological roles of different p24 proteins, we generated mice deficient in the expression of one family member, p23 (also called 24delta1, see for alternative nomenclature)...
  51. ncbi Discovery of new human beta-defensins using a genomics-based approach
    H P Jia
    Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Gene 263:211-8. 2001
    ..In the human genome, all known defensin genes cluster to a <1 Mb region of chromosome 8p22-p23. To identify new defensin genes, the DNA sequence from a contig of large-insert genomic clones from the region ..
  52. pmc Multiple roles for tumor necrosis factor-alpha and lymphotoxin alpha/beta in immunity and autoimmunity
    Hugh McDevitt
    Department of Microbiology and Immunology, Stanford University Medical Center, California 94305, USA
    Arthritis Res 4:S141-52. 2002
    ..to cause a downregulation of signaling through the TCR, revealed by changes in calcium flux, activation of p21, p23 and ZAP70, and a decrease in nuclear activation of NF-kappaB...
  53. ncbi Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells
    Marina Premyslova
    Canadian Institute of Health Research, Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 88:6040-7. 2003
    ..of chorioamnionitis on the protein expression of microsomal and cytosolic prostaglandin E(2) synthases (mPGES and cPGES) in preterm human placentae (PL) and fetal membranes (FM), by Western blot and immunohistochemistry, as well as ..
  54. ncbi Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1
    Jocelyne Guay
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec H9H 3L1, Canada
    J Biol Chem 279:24866-72. 2004
    ..The cytosolic PGE(2) synthase (cPGES) showed a small transient increase during the early phase, whereas mPGES-2 expression was not affected by ..
  55. pmc Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70
    Amerigo Carrello
    Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research, The University of Western Australia, Nedlands, Western Australia 6009, Australia
    Cell Stress Chaperones 9:167-81. 2004
    ..heat shock protein (Hsp)90; one of the immunophilins cyclophilin 40 (CyP40), FKBP51, or FKBP52; and an additional p23 protein component...
  56. pmc Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Shiga, Japan
    Eur J Immunol 35:3187-95. 2005
    ..we demonstrate that agonist stimulation of Th1 cells leads to the predominant appearance of fully phosphorylated (p23) TCR zeta, substantial phosphorylation of zeta-associated protein 70 (ZAP-70), and strong elevation of ..
  57. ncbi Analysis of gene expression profile of TPM3-ALK positive anaplastic large cell lymphoma reveals overlapping and unique patterns with that of NPM-ALK positive anaplastic large cell lymphoma
    Sandra D Bohling
    Department of Pathology, University of Washington Medical Center, Seattle, WA, United States
    Leuk Res 32:383-93. 2008
    ..While the most common translocation is the t(2;5)(p23;q35) involving the nucleophosmin (NPM) gene on chromosome 5, up to 12 other translocations partners of the ALK gene ..
  58. pmc Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats
    Chun Shiang Chung
    Department of Biochemistry, Microbiology and Molecular Genetics, University of Rhode Island, Kingston, RI 02881 USA
    Pharmacol Biochem Behav 89:137-44. 2008
    ..consumption, Long-Evans (LE) rats were fed an ethanol-containing liquid diet starting at postnatal (P) ages (days): P23-27 (juvenile), P35-45 (adolescent) or P65-97 (young adult)...
  59. doi Endometrial expression of selected transcripts involved in prostaglandin synthesis in cows with endometritis
    C Gabler
    Institute of Veterinary Biochemistry, Freie Universitat Berlin, Oertzenweg 19b, 14163 Berlin, Germany
    Theriogenology 71:993-1004. 2009
    ..mRNA expression of interleukin 1alpha (IL-1alpha), interleukin receptor antagonist (IL-1-RN), cytosolic prostaglandin E synthase (cPGES), microsomal PGES (mPGES-1 and mPGES-2) and lipocalin-type PGDS (L-PGDS) in the bovine ..
  60. pmc Fate of minus-strand templates and replication complexes produced by a p23-cleavage-defective mutant of Sindbis virus
    Junbo Mai
    Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    J Virol 83:8553-64. 2009
    SIN2V is an engineered mutant Sindbis virus (SIN) that is unable to process the P23 cleavage site in polyproteins P123 and P1234 that are translated from the genome after its entry into cells...
  61. doi Structural alterations of spiny stellate cells in the somatosensory cortex in ephrin-A5-deficient mice
    Andre Guellmar
    Universitat Jena, Institut für Allgemeine Zoologie und Tierphysiologie, 07743 Jena, Germany
    J Comp Neurol 517:645-54. 2009
    ..afferents establish synaptic contacts and the dendrites of their target cells are covered with filopodia, and at P23, after synapse formation and replacement of filopodia by spines...
  62. ncbi p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway
    D Gommel
    Biochemie Zentrum, Heidelberg, University of Heidelberg, Germany
    FEBS Lett 447:179-85. 1999
    COPI-coated vesicles that bud off the Golgi complex contain two major transmembrane proteins, p23 and p24. We have localized the protein at the Golgi complex and at COPI-coated vesicles...
  63. doi Glycinergic synaptic currents in the deep cerebellar nuclei
    Christine M Pedroarena
    Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Neuropharmacology 54:784-95. 2008
    ..fibers and terminals showed low density of immuno-fluorescent puncta, putative glycinergic boutons surrounding P18-P23 DCNs, in agreement with the rare spontaneous synaptic activity...
  64. pmc Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
    Marta Persson
    Department of Pathology, Lundberg Laboratory for Cancer Research, the Sahlgrenska Academy at University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 106:18740-4. 2009
    ..We show that the t(6;9)(q22-23;p23-24) translocation in adenoid cystic carcinomas (ACC) of the breast and head and neck consistently results in ..
  65. ncbi Lipase activation by nonionic detergents. The crystal structure of the porcine lipase-colipase-tetraethylene glycol monooctyl ether complex
    J Hermoso
    Laboratoire de Cristallographie et de Cristallogenese des Proteines, Institut de Biologie Structurale Jean Pierre Ebel, CEA CNRS, Grenoble, France
    J Biol Chem 271:18007-16. 1996
    ..1 A and display a strong pseudo-symmetry corresponding to a P23 lattice. Unexpectedly, the crystalline two-domain lipase is found in its open configuration...
  66. ncbi Phagosome number and distribution in retinal pigment epithelial cells of vitiligo mutant mice
    B Kosaras
    New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
    Exp Eye Res 63:151-8. 1996
    ..Post-natal day 23 (P23) and P36 mutant and congenic control wild-type mice were kept in darkness overnight and eyes were examined by light ..
  67. ncbi Intracellular localization and in vivo trafficking of p24A and p23
    R Blum
    Institute of Physiology II, Medical Biochemistry and Department of Anatomy, University of the Saarland, D 66421 Homburg Saar, Germany
    J Cell Sci 112:537-48. 1999
    Recently, p24A and p23 (also termed Tmp21), two members of the p24 protein family, have been proposed to function as integral receptors for the COPI-vesicle coat...
  68. pmc Behcet's disease associated with myelodysplastic syndrome: a case report
    E J Oh
    Department of Clinical Pathology, Catholic University of Korea, Seoul, Korea
    J Korean Med Sci 14:685-7. 1999
    ..Chromosomal analysis of bone marrow cells revealed 46,XX,-8,-20,+der(8)t(8;20)(p23;p10),+der(8) t(8;20)(p23;q10)[30]...
  69. pmc The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder
    C S Lai
    The Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Am J Hum Genet 67:357-68. 2000
    ..However, we found that the t(2;7)(p23;q31.3) breakpoint in the second patient (BRD) resides within a BAC clone mapping >3...
  70. ncbi Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression
    Rui Han
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Biol Chem 277:16355-64. 2002
    ..b>cPGES is cytoplasmic, apparently identical to the hsp90 chaperone, p23, and associates functionally with prostaglandin-..
  71. ncbi Eosinophilic leukemia associated with t(2;5)(p23;q31)
    Stephane Lepretre
    Department of Haematology, Centre Henri Becquerel, Rue d Amiens, 76038 Rouen Cedex, France
    Cancer Genet Cytogenet 133:164-7. 2002
    ..We describe a patient with eosinophilic leukemia whose cytogenetic study shows a t(2;5)(p23;q31)...
  72. ncbi Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation
    Andrei I Ivanov
    Trauma Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1104-17. 2002
    ..Neither sPLA(2)-V nor cPGES was induced by LPS...
  73. ncbi [Prostaglandin E2 synthases]
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Nihon Yakurigaku Zasshi 120:373-8. 2002
    ..We identified two distinct glutathione-dependent PGESs. Cytosolic PGES (cPGES), known as p23, is constitutively and ubiquitously expressed and predominantly converts COX-1-derived PGH2 to PGE2...
  74. pmc Duplication and selection in the evolution of primate beta-defensin genes
    Colin A M Semple
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Genome Biol 4:R31. 2003
    ..Here we use a combination of laboratory and computational techniques to characterize the main human beta-defensin locus on chromosome 8p22-p23.
  75. ncbi A Plasmodium homologue of cochaperone p23 and its differential expression during the replicative cycle of the malaria parasite
    Mark F Wiser
    Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL17, New Orleans, LA 70112, USA
    Parasitol Res 90:166-70. 2003
    ..gene sequence of a major phosphoprotein from the malaria parasite reveals that it is a homologue to cochaperone p23. This p23 homologue is highly conserved between Plasmodium falciparum and other malaria parasites and exhibits 44% ..
  76. pmc Functional reconstitution of COPI coat assembly and disassembly using chemically defined components
    Constanze Reinhard
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:8253-7. 2003
    ..In this experimental system, the coat components coatomer and GTP-bound ADP-ribosylation factor (ARF), as well as p23 as a membrane-bound receptor for COPI coat proteins, were shown to be both necessary and sufficient to promote COPI-..
  77. ncbi Function of HSP90 and p23 in the telomerase complex of thyroid tumors
    Carsten Boltze
    Department of Pathology, Otto von Guericke University and 2 City Hospital, Magdeburg, Germany
    Pathol Res Pract 199:573-9. 2003
    ..Previously, the chaperones p23 and HSP90 have been described as additional telomerase regulators...
  78. ncbi Evolutionary epitopes of Hsp90 and p23: implications for their interaction
    Shunyi Zhu
    Laboratory of Toxicology, University of Leuven, Belgium
    FASEB J 18:940-7. 2004
    ..domain (N-domain) of Hsp90 represents the ATP binding site and is important for interaction with its cochaperone, p23. Whereas some evidence suggests that p23 may bind to this domain in an ATP-dependent manner and that this process ..
  79. ncbi Deletion 6p23 and add(11)(p15) leading to NUP98 translocation in a case of therapy-related atypical chronic myelocytic leukemia transforming to acute myelocytic leukemia
    Akihiro Takeshita
    Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu shi, 431 3192, Japan
    Cancer Genet Cytogenet 152:56-60. 2004
    ..karyotyping analysis, and dual-color fluorescence in situ hybridization showed this abnormality as 46,XY,del(6)(p23),add(p15). ish del(6)(NUP98-,D6Z1+),der(7)(NUP98+,D7Z1+),der(11)(NUP98+,D11Z1)...
  80. ncbi Binding of a 23 kD endonuclease to the rat liver nuclear matrix
    N Grdovic
    Department of Molecular Biology, Institute for Biological Research, Despot Stephen Boulevard 142, 11060 Belgrade, Serbia and Montenegro
    Gen Physiol Biophys 24:99-111. 2005
    In a previous paper we have described a 23 kD nuclear endonuclease (p23) that was mostly found to exist in a state of association with the isolated rat hepatocyte nuclear matrix...
  81. ncbi Linear chromosome maintenance in the absence of essential telomere-capping proteins
    Mikhajlo K Zubko
    Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Nat Cell Biol 8:734-40. 2006
    ..ends, binding the G-rich, 3' single-stranded overhang at telomeres include Pot1 in humans and fission yeast, TEBP in Oxytricha nova and Cdc13 in budding yeast...
  82. ncbi Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells
    Mami Nagataki
    Division of Physiology and Pathophysiology, Kinki University School of Pharmacy, Higashi Osaka, Japan
    Cell Biochem Funct 26:279-82. 2008
    ..of three isozymes of prostaglandin E synthase (PGES), microsomal PGES-1 (mPGES-1), mPGES-2 and cytosolic PGES (cPGES) in COX-2-dependent prostaglandin E(2) (PGE(2)) formation following proteinase-activated receptor-2 (PAR2) ..
  83. doi Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes
    A M Abu El-Asrar
    Department of Ophthalmology, King Abdulaziz University Hospital, Old Airport Road, Riyadh, Saudi Arabia
    Br J Ophthalmol 92:1534-9. 2008
    ..the expression of COX-2 and its downstream enzymes microsomal prostaglandin-E synthase (mPGES)-1, cytosolic PGES (cPGES) and thromboxane synthase (TXS), and correlated it with vascular endothelial growth factor (VEGF) expression and ..
  84. doi Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artific
    Carolina Gillio-Meina
    Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada
    Reproduction 137:537-52. 2009
    ..PG-endoperoxide synthases (PTGS1 and PTGS2), microsomal PGE synthases (PTGES and PTGES2), cytosolic PGE synthase (PTGES3), prostacyclin synthase (PTGIS), prostacyclin receptor, peroxisome proliferator-activated receptor delta (PPARD) ..
  85. pmc The closest relatives of icosahedral viruses of thermophilic bacteria are among viruses and plasmids of the halophilic archaea
    Matti Jalasvuori
    Department of Biological and Environmental Science and Nanoscience Center, University of Jyvaskyla, Finland
    J Virol 83:9388-97. 2009
    ..the genome and identified the structural proteins and lipids of the novel membrane-containing, icosahedral virus P23-77 of Thermus thermophilus...
  86. pmc A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
    Jacob J Gano
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Proteomics 9:255-70. 2010
    ..Together these findings suggest that the HSP90 interactome is dynamic with respect to nucleotide and drug ligands and that pharmacological inhibition of HSP90 may stimulate the formation of specific complexes...
  87. pmc Mutations in C2ORF71 cause autosomal-recessive retinitis pigmentosa
    Rob W J Collin
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Hum Genet 86:783-8. 2010
    ..The families were found to share a 5.9 Mb homozygous region on chromosome 2p23.1-p23.3...
  88. pmc The Hsp90 co-chaperone p23 of Toxoplasma gondii: Identification, functional analysis and dynamic interactome determination
    Pablo C Echeverria
    Laboratorio de Parasitologia Molecular, UB2, IIB INTECH, CONICET UNSAM, Camino de Circunvalación Laguna Km 6, C C 164, B7130IIWA Chascomús, Prov Buenos Aires, Argentina
    Mol Biochem Parasitol 172:129-40. 2010
    ..gondii Hsp90 chaperone machinery and parasite development was observed. Here, the T. gondii Hsp90 co-chaperones p23 and Hip were identified mining the Toxoplasma- database (www.toxodb.org)...
  89. doi PGD for a complex chromosomal rearrangement by array comparative genomic hybridization
    E Vanneste
    Center for Human Genetics, UZ Gasthuisberg, 3000 Leuven, Belgium
    Hum Reprod 26:941-9. 2011
    ..We performed PGD for a CR carrier with karyotype 46,XY,ins(3;2)(p23;q23q14.2),t(6;14)(p12.2;q13) using array comparative genomic hybridization...
  90. doi An analysis of nicotine conditioned place conditioning in early postweanling and adolescent rats neonatally treated with quinpirole
    Marla K Perna
    Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA
    Behav Brain Res 220:254-61. 2011
    ..quinpirole or saline from postnatal day (P)1-21, and animals were conditioned with nicotine or saline daily from P23-30 as early postweanlings or P32-39 as adolescents in a two- or three-chambered place conditioning apparatus...
  91. doi Interactions of protein side chains with RNA defined with REDOR solid state NMR
    Wei Huang
    Department of Chemistry, University of Washington, Box 351700, Seattle, Washington, DC 98195, USA
    J Biomol NMR 51:347-56. 2011
    ..in a Tat-derived peptide, using (19)F spins incorporated into the base of U23 in TAR and (31)P spins in the P22 and P23 phosphate groups...
  92. pmc Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
    Dave Boucher
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Proc Natl Acad Sci U S A 109:5669-74. 2012
    ..sequence preference as caspase-3, is better at cleaving poly(ADP ribose) polymerase 1 (PARP) and Hsp90 cochaperone p23, despite a lower intrinsic activity...
  93. doi Type 1 inositol-1,4,5-trisphosphate receptor is a late substrate of caspases during apoptosis
    Ghadi Elkoreh
    Faculty of Medicine and Health Sciences, Department of Pharmacology, Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, Sherbrooke QC J1H 5N4, Canada
    J Cell Biochem 113:2775-84. 2012
    ..its cleavage occurs only after poly(ADP-ribose) polymerase (PARP), which cleavage is a hallmark of apoptosis, and p23, a poor caspase-7 substrate, are completely cleaved, suggesting that IP(3) R-1 is a relatively late substrate of ..
  94. pmc Characterization of a complex rearrangement involving duplication and deletion of 9p in an infant with craniofacial dysmorphism and cardiac anomalies
    Daniel L Di Bartolo
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College NewYork Presbyterian Hospital, New York, NY, USA
    Mol Cytogenet 5:31. 2012
    ..Conventional cytogenetic analysis identified additional material on chromosome 9 at band p23. FISH analysis aided in determining the additional material consisted of an inverted duplication with a terminal ..
  95. pmc Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis
    Chaitanya A Patwardhan
    Cancer Research Center, Molecular Chaperones Program, Georgia Regents University, Augusta, Georgia 30912, USA
    J Biol Chem 288:7313-25. 2013
    ..The clinical efficacy of Hsp90 inhibitors is, however, less than expected. Binding of the co-chaperone p23 to Hsp90 and induced overexpression of anti-apoptotic proteins Hsp70 and Hsp27 are thought to contribute to this ..
  96. ncbi Chemical compositions, phytotoxicity, and biological activities of Acorus calamus essential oils from Nepal
    Prabodh Satyal
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    Nat Prod Commun 8:1179-81. 2013
    Four essential oils from the leaf (P23) and rhizomes (P19, P22, P24) of Acorus calamus L., collected from various parts of Nepal, were obtained by hydrodistillation and analyzed by GC-MS...
  97. pmc Virus-viroid interactions: Citrus Tristeza Virus enhances the accumulation of Citrus Dwarfing Viroid in Mexican lime via virus-encoded silencing suppressors
    Pedro Serra
    Centro de Proteccion Vegetal y Biotecnologia, Instituto Valenciano de Investigaciones Agrarias, Moncada, Valencia, Spain
    J Virol 88:1394-7. 2014
    ..Since CTV encodes three RNA silencing suppressors (RSSs), p23, p20 and p25, an assay using transgenic Mexican limes expressing each RSS revealed that p23 and, to a lesser extent,..
  98. pmc Methylmercury alters the activities of Hsp90 client proteins, prostaglandin E synthase/p23 (PGES/23) and nNOS
    Samuel Caito
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 9:e98161. 2014
    ..as the abundance of complexes of Hsp90-neuronal nitric oxide synthase (nNOS) and Hsp90-prostaglandin E synthase/p23 (PGES/p23) were assessed...
  99. doi p23 and Aha1
    Alexandra Beatrice Rehn
    Department Chemie, Technische Universitat Munchen, Munich, Germany
    Subcell Biochem 78:113-31. 2015
    ..b>p23 and Aha1 are two prominent examples with opposing effects on the ATPase activity of Hsp90...
  100. doi [Confirmation of a maternal cryptal balanced translocation through analysis of a fetus using microarray]
    Jianzhu Wu
    Fetal Medicine Center, Department of Gynaecology and Obstetrics, The First Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510080, P R China email
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 32:69-72. 2015
    ..To analyze a fetus with heart defects and to assess the recurrence risk for her family...
  101. pmc Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent
    Angela Vandenberg
    Neuroscience Graduate Program, University of California San Francisco, CA, USA
    Front Neural Circuits 9:5. 2015
    ..Systemic disruption of tyrosine kinase receptor B (TrkB) signaling during P23-50 in TrkBF616A mice blocked developmental changes in mIPSC amplitude, without affecting miniature excitatory post ..

Research Grants50

  1. Dynamics of Transcriptional Regulation
    Elena Zelin; Fiscal Year: 2011
    ..Using biochemical, molecular biological and cellular biological assays, I will test the hypothesis that the p23 molecular chaperone disengages DNA-bound transcription factors and that the longevity of the dissociation is ..
  2. Dynamic signaling by intracellular hormone receptors
    Brian C Freeman; Fiscal Year: 2010
    ..To address the premise that the p23 and Hsp90 molecular chaperones alter the DNA binding state of select transcription factors including IRs and that ..
  3. Ahmed Chadli; Fiscal Year: 2014
    ..clients of Hsp90, and the core components of the Hsp90 chaperoning machine (Hsp90, Hsp70, Hsp40, Hop, and p23)...
  4. The Role of NPM-ALK Signaling in Tumor Cell Metabolism
    SCOTT RP MCDONNELL; Fiscal Year: 2012
    ..The major genetic event present in 80% of these tumors is the chromosomal translocation t (2;5)(p23;q35) resulting in the aberrant expression of the fusion protein nucleophosmin - anaplastic lymphoma kinase (NPM-ALK)..
  5. Brian C Freeman; Fiscal Year: 2015
    ..network we have exploited high-throughput approaches to identify genetic and physical interactors of the yeast p23 cochaperone Sba1, which serves one branch of the yeast Hsp90 (Hsp82) chaperone system...
  6. Gene Expression in Rat Cochlea Following Loss of Hair Cells
    Erin Bailey; Fiscal Year: 2013
    ..These time points were chosen based on the course of SGN death: P23 corresponds to the onset of SGN death, a statistically significant amount of SGN degeneration has occurred by P32, ..
  7. Proteomic biomarkers of ALK+ lymphoma
    Megan S Lim; Fiscal Year: 2013
    ..ALCL represents about 10% of all childhood non-Hodgkin lymphoma (NHL). The t(2;5)(p23;q35) chromosomal aberration resulting in overexpression of a chimeric oncogene, nucleophosmin-anaplastic lymphoma ..
  8. c-Myb fusion proteins in Adenoid Cystic Carcinoma
    Timothy P Bender; Fiscal Year: 2012
    ..Stenman and colleagues have recently identified a recurrent and tumor specific t(6;9)(q22-23;p23-24) chromosomal translocation that involves the MYB and NFIB loci in adenoid cystic carcinoma (ACC)...
  9. Sanjiv S Gambhir; Fiscal Year: 2016
    ..gene technologies for small animal imaging, including studying of heat shock protein 90 (Hsp90)/co-chaperone p23 interactions in cancer...
  10. Chaperone-mediated signaling in Alzheimer's disease
    Chad A Dickey; Fiscal Year: 2010
    ..specifically involved in p-tau degradation have been identified, we have found that the re-folding co-chaperone, P23, may also regulate tau biology, acting rather to prevent its degradation...
  11. Role of MAP kinases in anaplastic large cell lymphoma
    Youli Zu; Fiscal Year: 2009
    ..ALCL have an abnormal chromosome translocation t(2;5)(p23;q35), which results in a fusion gene composed of nucleophosmin (NPM) and a truncated tyrosine kinase, named ..
  12. Cell Biology of Presenilin 1 and Associated Proteins
    Gopal Thinakaran; Fiscal Year: 2012
    ..main subunits, namely PS1 (or PS2), nicastrin, PEN2 and APH-1, and a few regulatory subunits including CD147 and p23 (also referred to asTMP21). PS1 is thought to function as the catalytic subunit of gamma-secretase complex...
  13. Studies on the Ah Receptors Signaling Mechanism
    William K Chan; Fiscal Year: 2010
    ..We discovered that p23 and CyP40 potentiate the formation of this AhR ternary complex in vitro (Refs: 1. Shetty, P. V., Wang, X...
  14. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
    ..We described the presence of both the cytosolic and microsomal PGE synthase isoforms (cPGES and mPGES) in fetal membranes but that their expression did not change with gestational age or labor, nor were ..
  15. EMMANUELLE JOELLE MEUILLET; Fiscal Year: 2014
    ..Two microsomal isoforms for mPGES (mPGES-1 and mPGES-2) and one cytosolic form (cPGES-3) have been identified...
  16. Investigation of C. elegans NUD-1 in Centrosome Function and Mitosis
    KIM CALDWELL; Fiscal Year: 2006
    ..Importantly, Hsp90 activity is dependent upon a co-chaperone termed p23, a protein that shares significant structural homology with NUD-1/NudC...
  17. IMMUNOPHILIN INTERACTIONS WITH STEROID RECEPTORS
    David Smith; Fiscal Year: 2006
    ..Functionally mature receptor complexes consist of a receptor monomer, an Hsp90 dimer, the cochaperone p23, and one of the immunophilin class of Hsp90-binding cochaperones...
  18. Chaperone-mediated signaling in Alzheimer's disease
    Chad Dickey; Fiscal Year: 2007
    ..specifically involved in p-tau degradation have been identified, we have found that the re-folding co-chaperone, P23, may also regulate tau biology, acting rather to prevent its degradation...
  19. Joint degeneration: Somatic mosaic analysis in a transgenic mouse
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..COX-2, as well as other members of the cyclooxygenase-prostaglandin pathway, including COX-1, mPGES-1 and cPGES. We propose to express these siRNA constructs intra-articulalry using a feline immuno-deficiency viral platform, ..
  20. Organizaton of the Hsp90/Hsp70-Based Chaperone Machinery
    Patrick Murphy; Fiscal Year: 2009
    ..reticulocyte lysate and have developed a minimal system consisting of five proteins - hsp90, hsp70, Hop, hsp40, p23 - that carries out efficient signaling protein-hsp90 heterocomplex assembly...
  21. MOLECULAR EFFECTS OF SPECIFIC HIV PROTEINS ON THE CNS
    Dale Bredesen; Fiscal Year: 1993
    ..of inducible expression vectors for HIV proteins SU (gp120), TM(gp41) (and gp 160 separately), CA (p24), and VIP (p23). (3) Stable transfections of the constructs into the human cell lines at 34 degrees...
  22. Progesterone Receptor and the hsp90 Chaperone Pathway
    David Toft; Fiscal Year: 2005
    ..complex formation are hsp70, three hsp70 co-chaperones, hsp40, Hip and Hop, four hsp90-binding TPR proteins and p23. We have developed a chemically defined system with purified proteins that has the capacity to assemble PR ..
  23. IL-1nduced Mediators of CNS Inflammation and AD: PGE
    MICHAEL O BANION; Fiscal Year: 2006
    ..We further postulate that COX-1 activity coupled to cytosolic PGE synthase (cPGES) is required as a first phase for efficient PGE2 synthesis in cultured astrocytes and in brain...
  24. Biochemical Effects of Disrupting HSP90
    Charles Erlichman; Fiscal Year: 2004
    ..cell sensitivity to GA in a colony-forming assay that is correlated with inhibition of binding of the co-chaperone p23 to HSP90, decreased intracellular concentrations of GA, and increased levels of the co-chaperone HDJ2...
  25. AN ENDOGENOUS STEROID RECEPTOR STABILIZING FACTOR
    WILLIAM PRATT; Fiscal Year: 2005
    ..machinery consists of the essential chaperones hsp90 and hsp70 and the non-essential cp-chaperones hsp40, Hop and p23. Recently, we have developed a two-step system of GR-hsp90 heterocomplex assembly in which immobilized GR is ..
  26. P27Kip1 in Hepatocyte Proliferation
    Liang Zhu; Fiscal Year: 2006
    ..In Specific Aim 1, we will generate hepatocyte-specific, inducible p23 knockout mice to study the role of p23 in hepatocytes at various stages in the liver...
  27. MOLECULAR ANALYSIS OF CHROMOSOME ABERRATIONS IN CANCER
    Susan Naylor; Fiscal Year: 1991
    ..SCLC has been demonstrated cytogenetically to possess a deletion in the short arm of chromosome 3 (bands p14 to p23)...
  28. NOVEL ASSAY TO DETECT TRANSLOCATION IN LEUKEMIAS
    LUIS YANEZ; Fiscal Year: 1991
    ..leukemia with preB phenotype; t(15;17) (q21;q11) associated with acute promyeloctic leukemia; and t(6;9) (p23;q34) associated with acute myelomonocytic leukemia...
  29. TPR Proteins in Steroid Receptor Signaling & Physiology
    EDWIN SANCHEZ; Fiscal Year: 2009
    ..A better understanding of differential TPR protein effects on both GR and PR could now form the basis for new therapeutic strategies targeting fertility and other physiologies. ..
  30. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  31. REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D
    Daniel Bikle; Fiscal Year: 2001
    ..These manipulations will all be tested for their ability to block 1,25D-stimulated calcium transport. ..
  32. REGULATION OF GLUCOCORTICOID RECEPTOR BY PHOSPHORYLATION
    Michael Garabedian; Fiscal Year: 2002
    ....
  33. IDENTITY AND FUNCTION OF VERTEBRATE TELOMERE PROTEINS
    Carolyn Price; Fiscal Year: 2002
    ..We will use a retroviral cDNA expression library to screen for genes that act as high copy suppressors of defects in telomere function. ..
  34. REGULATION OF ANDROGEN RECEPTOR ACTIVITY IN THE PROSTATE
    Michael Garabedian; Fiscal Year: 2003
    ..abstract_text> ..
  35. VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES
    Daniel Bikle; Fiscal Year: 2003
    ..abstract_text> ..
  36. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
  37. Effects/Ethanol/Specific sites/AMPA glutamate receptors
    BABATUNDE AKINSHOLA; Fiscal Year: 2004
    ..This grant will contribute significantly to the career establishment and development of the investigator by providing the time, salary support and supplies needed for education and training in alcohol research in a minority institution. ..
  38. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  39. Regulation of Prostaglandin E Synthases in Parturition
    William Ackerman; Fiscal Year: 2004
    ..We hope to support the hypothesis that, as in other systems, microsomal PGES is functionally linked to COX-2 in the generation of uterotonic POE2. ..
  40. Conference Proposal to support FASEB Conference on Ciliate Molecular Biology
    Carolyn Price; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. Regulation of the Hsp90 Co-chaperone Network
    Steven Hartson; Fiscal Year: 2004
    ..The research proposed will elucidate the composition and dynamic regulation of a discrete protein network that supports human development, and will characterize how environmental stress may dysregulate this network. ..
  42. HEAT SHOCK AND STEROID RECEPTOR SIGNALING
    EDWIN SANCHEZ; Fiscal Year: 2005
    ....
  43. Physiological Roles of Receptor-Associated Immunophilins
    MARC COX; Fiscal Year: 2007
    ..Thus, these studies could also contribute drugs to a better understanding of the mechanism by which patients acquire resistance to corticosteroid drugs. [unreadable] [unreadable]..
  44. Quantitative RT-PCR: Prediction Lymphoma Transformation
    Kojo Elenitoba Johnson; Fiscal Year: 2005
    ....
  45. Function & Regulation of two Novel PARPs, tankyrase 1&2
    Carolyn Price; Fiscal Year: 2008
    ..Aim 4 will investigate the in vivo regulation of tankyrase PARP activity. We will examine the in vivo levels of tankyrase poly(ADP-ribosyl)ation and whether this is regulated by phosphorylation. ..
  46. RNAP-binding proteins encoded by Thermus phages
    Leonid Minakhin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. Role of Jak3 in Anaplastic Large Cell Lymphoma
    HESHAM AMIN; Fiscal Year: 2008
    ..The direct aim of the proposed studies is to validate Jak3 as a therapeutic target in patients afflicted with this dreadful disease. [unreadable] [unreadable] [unreadable]..
  48. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  49. Severe Asthma and the Glucocorticoid Receptor Complex
    Gregory Hawkins; Fiscal Year: 2006
    ..shock protein 70 (hsc70 and hsp70 [1A and 1B]), heat shock protein 40 (hsp40), hsp organizing protein (hop), and p23. Genes for these eight proteins required for proper assembly of an active GR complex will be re-sequenced in a ..
  50. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..