PTGER2

Summary

Gene Symbol: PTGER2
Description: prostaglandin E receptor 2
Alias: EP2, prostaglandin E2 receptor EP2 subtype, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, prostaglandin E receptor 2 (subtype EP2), 53kD, prostaglandin E receptor 2 (subtype EP2), 53kDa, prostanoid EP2 receptor
Species: human

Top Publications

  1. doi Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostaglandin E2 (PGE2) serum level in ovarian cancer
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Steroid Biochem Mol Biol 121:387-90. 2010
  2. ncbi Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, 00158 Rome, Italy
    J Biol Chem 279:46700-5. 2004
  3. ncbi Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites
    Dawn Bradbury
    Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 280:29993-30000. 2005
  4. doi Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A
    Elena Sokolova
    Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Germany
    FEBS J 275:3669-79. 2008
  5. pmc Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration
    S Mark Duffy
    The Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Eur J Immunol 38:2548-56. 2008
  6. ncbi PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer
    V A Takafuji
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
    Prostaglandins Leukot Essent Fatty Acids 66:71-81. 2002
  7. ncbi Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes vascular endothelial growth factor expression via cyclic 3',5'-adenosine monophosphate-mediated transactivation of the epidermal growth factor receptor and extracellular sign
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, Edinburgh, Scotland EH16 4SB, United Kingdom
    Mol Endocrinol 18:1533-45. 2004
  8. ncbi Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling
    Steven Huang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 292:L405-13. 2007
  9. ncbi Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas
    Y Sugino
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Oncogene 26:7401-13. 2007
  10. pmc EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway
    A B Abera
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Cell Signal 22:71-9. 2010

Research Grants

  1. CYCLOOXYGENASE AND TUMORIGENESIS
    Daniel Hwang; Fiscal Year: 2003
  2. IL-1nduced Mediators of CNS Inflammation and AD: PGE
    MICHAEL O BANION; Fiscal Year: 2006
  3. Jianxiong Jiang; Fiscal Year: 2014
  4. SYLVAIN DORE; Fiscal Year: 2014
  5. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
  6. Role of COX2 of Neuronal Origin in Blood-Brain Communication after status epilept
    Raymond J Dingledine; Fiscal Year: 2012
  7. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
  8. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
  9. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
  10. Regulation of PAF Acetylhydrolase Expression by Oxidized Phospholipids
    SUZANNE BARBOUR; Fiscal Year: 2009

Detail Information

Publications301 found, 100 shown here

  1. doi Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostaglandin E2 (PGE2) serum level in ovarian cancer
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Steroid Biochem Mol Biol 121:387-90. 2010
    ..Surprisingly, we could not detect any differences between the 25(OH2)D3 serum levels in either group (n=20). These data suggest a correlation between PG- and vitamin D-metabolism in ovarian carcinomas...
  2. ncbi Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, 00158 Rome, Italy
    J Biol Chem 279:46700-5. 2004
    ..E2 (PGE2) production, as the more represented PG types, and increases the expression of PGE2 receptor type 2 (EP2) and type 4 (EP4)...
  3. ncbi Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites
    Dawn Bradbury
    Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 280:29993-30000. 2005
    ..PGE receptor agonists EP2 (ONO-AE1 259) and EP4 (ONO-AE1 329) mimicked the effect of PGE2, and reverse transcription-PCR, Western blotting, ..
  4. doi Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A
    Elena Sokolova
    Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Germany
    FEBS J 275:3669-79. 2008
    ..Using the selective prostaglandin EP2 receptor agonist butaprost and cAMP-elevating agents, we show here that prostaglandin (PG)E(2), via the prostanoid ..
  5. pmc Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration
    S Mark Duffy
    The Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Eur J Immunol 38:2548-56. 2008
    ..1 in HLMC and attenuates both chemokine- and PGE(2)-dependent HLMC migration. EP(2) receptor agonists with K(Ca)3.1 modulating function may be useful for the treatment of mast cell-mediated disease...
  6. ncbi PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer
    V A Takafuji
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
    Prostaglandins Leukot Essent Fatty Acids 66:71-81. 2002
    ....
  7. ncbi Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes vascular endothelial growth factor expression via cyclic 3',5'-adenosine monophosphate-mediated transactivation of the epidermal growth factor receptor and extracellular sign
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, Edinburgh, Scotland EH16 4SB, United Kingdom
    Mol Endocrinol 18:1533-45. 2004
    Prostaglandin (PG) E(2) E-series prostanoid-2 (EP2) receptor is elevated in numerous carcinomas including the endometrium and has been implicated in mediating the effects of PGE(2) on vascular function...
  8. ncbi Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling
    Steven Huang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 292:L405-13. 2007
    ..Our data indicate that PGE(2) inhibits fibroblast activation in primary lung fibroblasts via binding of EP2 receptor and production of cAMP; inhibition of collagen I proceeds via activation of PKA.
  9. ncbi Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas
    Y Sugino
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Oncogene 26:7401-13. 2007
    ..a cluster of prostanoid receptor genes, prostaglandin D2 receptor (PTGDR) and prostaglandin E receptor 2 (PTGER2), as possible targets for DNA methylation in advanced types of neuroblastoma (NB) using bacterial artificial ..
  10. pmc EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway
    A B Abera
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Cell Signal 22:71-9. 2010
    ..that influences intracellular signaling and gene expression profiling in response to co-activation of the EP2 and FP prostanoid receptors in Ishikawa cells stably expressing both receptors (FPEP2 cells)...
  11. doi Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE-dependent secretion from human lung mast cells
    L J Kay
    Academic Unit of Respiratory Medicine, The Medical School, University of Sheffield, Sheffield, UK
    Clin Exp Allergy 43:741-51. 2013
    ..This effect of PGE2 is believed to be mediated by EP2 receptors...
  12. ncbi Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype
    S L Smock
    Department of Cardiovascular and Metabolic Diseases, Central Research Division, Pfizer, Inc, Eastern Point Road, Groton, CT, USA
    Gene 237:393-402. 1999
    Northern blot analysis of human placental RNA using a probe to the 5' end of the human prostaglandin E(2) (PGE(2)) EP2 receptor subtype coding region revealed the existence of a high abundance, low molecular weight transcript...
  13. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
    ..In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression...
  14. doi Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes
    Wei Ping Chen
    Department of Orthopedics Surgery, the Second Affiliated Hospital of Medical College, Zhejiang University, PR China
    Int Immunopharmacol 12:447-52. 2012
    ..In vivo study, morin exerted anti-inflammatory properties in an IL-1β-induced rat OA model. Our data suggest that morin possess potential value in the treatment of OA...
  15. pmc Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype
    G Molderings
    , , Germany
    Br J Pharmacol 107:352-5. 1992
    ..compounds mimicked the effect of prostaglandin E2 showing the following rank order of potencies: misoprostol (EP2-/EP3-receptor agonist) congruent to sulprostone (EP1-/EP3-receptor agonist) congruent to prostaglandin E1 = ..
  16. pmc Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
    E Talpain
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 114:1459-65. 1995
    ..15 +/- 0.03 microM, and a maximum effect ranging from 36-84% (mean inhibition of 68.7 +/- 2.5%, n = 32). 3. The EP2-receptor agonists, misoprostol, 11-deoxy PGE1, AH13205 and butaprost, all at 10 microM, inhibited O2- generation, ..
  17. ncbi Immunogenicity and specificity of the candidate multi-epitope-vaccines against HIV-1
    Y Lu
    Research Center for Medical Science and Department of Biology, Tsinghua University, Ministry of Education, Beijing, PR China
    Immunopharmacol Immunotoxicol 23:487-94. 2001
    ..antibodies against HIV-1, we designed two candidate multi-epitope-vaccines, EP1 [C-G-(ELDKWA-GPGRAFY)2-K] and EP2 (CG-GPGRAFY-G-ELDKWA-G-RILAVERYLKD), containing three neutralizing epitopes (GPGRAFY, ELDKWA and RILAVERYLKD) on ..
  18. ncbi Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists
    S Shinomiya
    Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Biochem Pharmacol 61:1153-60. 2001
    ..Among prostaglandin E (EP) receptor-selective synthetic agonists, EP2 and EP4 agonists caused down-regulation of the zymosan-induced TNFalpha production, but up-regulation on the IL-10 ..
  19. ncbi Prostaglandin E receptors in myometrial cells
    G Asboth
    1st Institute of Biochemistry, Semmelweis University of Medicine, Budapest, Hungary
    Acta Physiol Hung 85:39-50. 1997
    ..PGE2 may interact with at least four receptor subtypes (EP1, EP2, EP3, EP4), each showing different pharmacological profiles...
  20. ncbi Immunohistochemical demonstration of cyclooxygenase-2 (COX-2) and prostaglandin receptors EP2 and FP expression in the bovine intercaruncular uterine wall around term
    D Wehbrink
    Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Anim Reprod Sci 106:241-54. 2008
    ..In contrast to relaxant prostaglandin E receptor type 2 (EP2), not showing any change in all tissue layers observed, contractile prostaglandin F(2alpha) receptor (FP) was ..
  21. ncbi Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection
    Katharina Hösl
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Pain 126:46-53. 2006
    ..We have recently identified spinal prostaglandin E receptors of the EP2 subtype (EP2 receptors) and the glycine receptor alpha3 subunit (GlyR alpha3) as signal transduction elements ..
  22. pmc Modulation of noradrenaline release from the sympathetic nerves of the human saphenous vein and pulmonary artery by presynaptic EP3- and DP-receptors
    G J Molderings
    , , Germany
    Br J Pharmacol 111:733-8. 1994
    ..00. These effects were mimicked by prostaglandin E1, the EP1/EP3 receptor agonist, sulprostone and the EP2/EP3 receptor agonist, misoprostol with the rank order (pEC50): sulprostone (8.60) > PGE1 (7...
  23. pmc Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice
    T Minami
    Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan
    Br J Pharmacol 112:735-40. 1994
    ..3. 17-Phenyl-omega-trinor PGE2 (EP1 > EP3) and 16,16-dimethyl PGE2 (EP1 = EP2 = EP3) were as potent as PGE2 in inducing allodynia, and more potent than sulprostone...
  24. doi PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage
    S Otsuka
    Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Osteoarthritis Cartilage 17:529-38. 2009
    The effect of the prostaglandin E2 (PGE2) signal through prostaglandin E receptor 2 (EP2) receptors on the repair of injured articular cartilage was investigated using a selective agonist for EP2.
  25. ncbi Copresence of prostaglandin EP2 and EP3 receptors on gastric enterochromaffin-like cell carcinoid in African rodents
    Y Naribayashi-Inomoto
    Department of Internal Medicine, Kobe University School of Medicine, Japan
    Gastroenterology 109:341-7. 1995
    ..The aim of this study was to examine the possible presence of PG receptors on the gastric enterochromaffin-like (ECL) carcinoid of Mastomys natalensis, which might be a useful model of normal ECL cells...
  26. ncbi Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice
    C Miyaura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 275:19819-23. 2000
    ..and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype (EP1, EP2, EP3, and EP4) of PGE receptor...
  27. ncbi Effect of NMDA receptor antagonists on prostaglandin E2-induced hyperalgesia in conscious mice
    I Nishihara
    Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan
    Brain Res 677:138-44. 1995
    ..wide range of dosages with two apparent peaks at 100 pg and 10 ng per mouse, which may be mediated through EP3 and EP2 subtypes of the PGE receptor...
  28. ncbi Identification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells EP4 subtype
    N Nishigaki
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    FEBS Lett 364:339-41. 1995
    ..for a mouse PGE receptor positively coupled to adenylate cyclase from mouse mastocytoma cells, and reported it as EP2 subtype of PGE receptor [Honda, A., Sugimoto, Y., Namba, T., Watabe, A., Irie, A., Negishi, M., Narumiya, S...
  29. ncbi [Role of EP4 receptor in bone resorption induced by PGE]
    C Miyaura
    Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Nihon Yakurigaku Zasshi 117:293-7. 2001
    ..We examined PGE2-induced bone resorption using mice lacking each subtype (EP1, EP2, EP3 and EP4) of PGE receptor and identified the PGE receptor subtype(s) mediating PGE2 action...
  30. ncbi Effects of selective prostaglandin EP4 receptor antagonist on osteoclast formation and bone resorption in vitro
    M Tomita
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 30:159-63. 2002
    ..bone resorption by a cyclic AMP (cAMP)-dependent mechanism that involves prostaglandin E receptors of the EP2 and EP4 subtypes. We tested a potent selective EP4 antagonist (EP4RA), which blocks PGE(2) binding to EP4 receptors...
  31. ncbi Identification and characterization of a novel progesterone receptor-binding element in the mouse prostaglandin E receptor subtype EP2 gene
    Sohken Tsuchiya
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 8:747-58. 2003
    Gene expression of prostaglandin E receptor EP2 is induced in the luminal epithelium of the mouse uterus during peri-implantation period (day-5 of pseudopregnancy), suggesting the involvement of progesterone and its receptor (PR) in this ..
  32. doi Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4)
    Amy Ho Yan Kwok
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Gen Comp Endocrinol 157:99-106. 2008
    ..Together, our study establishes a molecular basis to understand the physiological roles of PGE(2) in target tissues of chicken...
  33. pmc Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear
    Ryusuke Hori
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    BMC Neurosci 11:35. 2010
    ..of prostaglandin E1 (PGE1) and prostaglandin E2 (PGE2) are mediated by the prostaglandin E receptor subtypes EP1, EP2, EP3, and EP4, and the respective agonists have been purified...
  34. pmc Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
    Yoshiyasu Esaki
    Departments of Pharmacology and Anesthesiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:12233-8. 2010
    ..mice manifested significant suppression of EAE, which was mimicked in wild-type mice and to a greater extent, in EP2(-/-) mice by administration of the EP4 antagonist ONO-AE3-208 during the immunization phase...
  35. ncbi Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype
    A Honda
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    J Biol Chem 268:7759-62. 1993
    A functional cDNA clone encoding mouse EP2 subtype of prostaglandin (PG) E receptor was isolated from a mouse cDNA library by cross-hybridization with the mouse EP3 subtype PGE receptor cDNA...
  36. pmc Characterization of the gene for the mouse prostaglandin E receptor subtype EP2: tissue-specific initiation of transcription in the macrophage and the uterus
    M Katsuyama
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan
    Biochem J 330:1115-21. 1998
    Genomic DNA clones for the mouse prostaglandin (PG) E receptor subtype EP2 were isolated and characterized. The mouse EP2 gene is composed of 2 exons and 1 intron, and spans 16 kb. The intron which is approx...
  37. ncbi The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis
    M Katsuyama
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    FEBS Lett 372:151-6. 1995
    A functional cDNA clone for the mouse prostaglandin (PG) E receptor EP2 subtype was isolated from a mouse cDNA library. The mouse EP2 receptor consists of 362 amino acid residues with seven putative transmembrane domains...
  38. ncbi Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype
    T A Hibbs
    Department of Cardiovascular and Metabolic Diseases, Pfizer, Inc, Groton, Connecticut 06340, USA
    Prostaglandins Other Lipid Mediat 57:133-47. 1999
    ..been implicated as a local mediator of bone anabolism via a cyclic AMP mediated pathway following activation of the EP2 and/or EP4 receptor subtype...
  39. ncbi Differential expression of prostaglandin E receptor subtype EP2 in rat uterus during early pregnancy
    J J Shi
    College of Life Sciences, Northeast Agricultural University, Harbin, China
    Histol Histopathol 20:1021-8. 2005
    PGE2 is essential for mammalian female reproduction. This study was to examine the expression of EP2 gene in the rat uterus during early pregnancy, delayed implantation and artificial decidualization by in situ hybridization and ..
  40. doi 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro
    Vivian Y Shin
    Department of Surgery, The University of Hong Kong, Hong Kong
    Cancer Sci 102:926-33. 2011
    ..Both in vitro and in vivo studies showed that NNK promoted cancer cell growth with concomitant EP2 and EP4 upregulation...
  41. doi Stimulation of tube formation mediated through the prostaglandin EP2 receptor in rat luteal endothelial cells
    Toshihiro Sakurai
    Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432 1, Hachioji, Tokyo 192 0392, Japan
    J Endocrinol 209:33-43. 2011
    ..The antagonist against the PGE receptor type 2 (EP2 receptor), AH6809, completely inhibited PGE(2)-induced tube formation and partly suppressed the VEGF-induced tube ..
  42. ncbi Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype
    T Sando
    Department of Medicine, Kyoto University Faculty of Medicine, Japan
    Biochem Biophys Res Commun 200:1329-33. 1994
    A cDNA clone encoding the rat prostaglandin (PG) E receptor EP2 subtype was cloned from a rat lung cDNA library. It encodes 488 amino acid residues with putative seven-transmembrane domains...
  43. ncbi Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C
    B L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 79:950-8. 2001
    ..PGE2-induced intracellular cAMP formation was mediated via prostaglandin E receptor 2 (EP2), but inhibition of cAMP formation and protein kinase A or blockade of EP1/EP2 receptors did not affect PGE2-..
  44. pmc Ontogenic increase in PGE2 and PGF2 alpha receptor density in brain microvessels of pigs
    D Y Li
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Br J Pharmacol 112:59-64. 1994
    ..displaced by AH 6809 (EP1-selective antagonist) by 80-90%, and only by approximately 30-35% by both 11-deoxy PGE1 (EP2/EP3 agonist) and M&B 28,767 (EP3 agonist); butaprost (EP2 agonist) was completely ineffective. 4...
  45. pmc Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum
    R A Lawrence
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 105:271-8. 1992
    ..b>EP2-receptors may be involved in the PGE action, in view of the marked effect of morphine on the contractile actions of ..
  46. ncbi Prostaglandin receptors: their role in regulating renal function
    M D Breyer
    Department of Medicine, Department of Veterans Affairs Medical Center, Vanderbilt University, Nashville, Tennessee, USA
    Curr Opin Nephrol Hypertens 9:23-9. 2000
    ..The FP, TP, and EP1 receptors preferentially couple to increased cell Ca2+. EP2, EP4, DP, and IP receptors stimulate cyclic adenosine monophosphate, whereas the EP3 receptor preferentially ..
  47. ncbi Long-term efficacy of antifungals in toenail onychomycosis: a critical review
    B J Cribier
    Clinique Dermatologique des Hôpitaux Universitaires, 1 place de l Hôpital 67091 Strasbourg, France
    Br J Dermatol 145:446-52. 2001
    ..Modern antifungal drugs achieve high mycological and clinical cure rates in onychomycosis of the toes, but little is known about the long-term evolution of the treated patients...
  48. ncbi Evidence for the presence of AH 13205-sensitive EP2-prostanoid receptors in the pregnant baboon but not in the pregnant sheep myometrium near term
    R Garcia-Villar
    Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    J Soc Gynecol Investig 2:6-12. 1995
    ..in pregnant sheep and baboons in an in vitro superfusion study, and to characterize further the PGE-sensitive (EP) receptor subtype involved in the myometrial response to PGE2 by using the selective prostanoid EP2 agonist AH 13205.
  49. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In wild-type (WT) mice and in mice lacking distinct PGE2 receptors (EP1-/-, EP2-/-, EP3-/-, and EP4-/-), the effect of chronic furosemide administration (7 d) on urine output, sodium and ..
  50. doi Evaluation of genes involved in prostaglandin action in equine endometrium during estrous cycle and early pregnancy
    Mehmet O Atli
    Department of OBGYN, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey
    Anim Reprod Sci 122:124-32. 2010
    ..Synthase-1 (PTGS1) and PTGS2, PGF synthase (PTGFS), and PGE synthase (PTGES), PGF receptor (PTGFR), PGE receptors (PTGER2 and PTGER4), prostaglandin transporter (SLCO2A1) and hydroxyprostaglandin dehydrogenase-15 (HPGD)...
  51. ncbi Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes
    Y Boie
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Que, Canada
    Eur J Pharmacol 340:227-41. 1997
    ..Finally, by Northern blot analysis EP3 transcripts were most abundant in liver and kidney whereas prostanoid EP2 receptor mRNA was expressed in spleen, lung and testis and prostanoid EP1 receptor mRNA transcripts were ..
  52. ncbi Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene
    T Arakawa
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 271:29569-75. 1996
    ..The levels of the EP2 and EP4 prostaglandin E2 (PGE2) receptors and the prostaglandin I2 receptor were changed in these cells by serum or ..
  53. pmc Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-alpha generation
    K K Meja
    Imperial College School of Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 122:149-57. 1997
    ..4. With respect to PGE2, the EP-receptor agonists, 16,16-dimethyl PGE2 (non-selective), misoprostol (EP2/EP3-selective), 11-deoxy PGE1 (EP2-selective) and butaprost (EP2-selective) were essentially full agonists as ..
  54. ncbi Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor
    Priscilla P Cherian
    Department of Biochemistry and Radiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:43146-56. 2003
    ..Here we show that fluid flow regulates gap junctions through the PGE2 receptor EP2 activation of cAMP-dependent protein kinase A (PKA) signaling...
  55. pmc Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues
    J S Matthews
    Department of Pharmacology, University of Edinburgh, Scotland
    Br J Pharmacol 108:363-9. 1993
    ..3) suggest the involvement of EP3-receptors as opposed to EP1- or EP2-subtypes. 2...
  56. pmc PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11beta-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa lutein cells
    C Chandras
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
    J Endocrinol 194:595-602. 2007
    ..shown these human ovarian cells to express functional G-protein coupled, E-series prostaglandin (PTGER)1, PTGER2 and PTGER4 receptors, the aim of this study was to delineate the roles of PTGER1 and PTGER2 receptors in mediating ..
  57. pmc In vitro characterization of prostanoid receptors on human myometrium at term pregnancy
    J Senior
    Postgraduate Studies in Pharmacology, University of Bradford
    Br J Pharmacol 108:501-6. 1993
    ..The EP2/EP3-receptor agonists, rioprostil and misoprostol, produced similar effects to PGE2, however, the excitatory event ..
  58. doi CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid c
    Chandra Prakash
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut, USA
    Drug Metab Dispos 36:2093-103. 2008
    CP-533,536, (3-{[(4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (1), an EP2 receptor-selective prostaglandin E2 agonist, is being developed to aid in the healing of bone fractures...
  59. doi A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells
    Hyunjoo Lee
    Laboratory of B Cell Biology, Karches Center for Chronic Lymphocytic Leukemia Research, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 185:5300-14. 2010
    ..paralleled by a division-related increase in a COX-2-linked enzyme, microsomal PGE(2) synthase-1, and the PGE(2)R, EP2. Cells with the greatest expression of AID expressed the highest levels of EP2...
  60. doi Effect of enrichment procedures on performance and microbial diversity of microbial fuel cell for Congo red decolorization and electricity generation
    Bin Hou
    State Key Laboratory of Pulp and Paper Engineering, Department of Environmental Science and Engineering, South China University of Technology, Guangzhou, China
    Appl Microbiol Biotechnol 90:1563-72. 2011
    ..enrichment procedures in which glucose and Congo red were added into the MFCs sequentially (EP1) or simultaneously (EP2) were tested by operating parallel MFCs independently for more than 6 months...
  61. pmc Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 85, Ghent, Belgium
    Respir Res 7:75. 2006
    ..We aimed with this study to investigate the tissue expression of leukotrienes and prostaglandin E2 receptors in chronic rhinosinusitis patients and the link of this regulation with eosinophilic inflammation...
  62. ncbi Role of EP3 and EP4 prostaglandin receptors in reorganization of the cytoskeleton in mature human osteoclasts
    Patrice Sarrazin
    Division of Rheumatology, Department of Medicine, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Rheumatol 31:1598-606. 2004
    ..We investigated the distribution and function of EP receptors in human mature osteoclasts...
  63. ncbi Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury
    Peng Zhao
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 27:2357-68. 2007
    ..regulator of PGE2 release, to microglial cells and a neuronal localization of the PGE2 receptor E-prostanoid 2 (EP2)...
  64. ncbi 'Distinct cellular localization' of the messenger ribonucleic acid for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancy
    M Katsuyama
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Endocrinology 138:344-50. 1997
    ..uterine actions of PGE2, expression patterns of the messenger RNAs (mRNAs) for four subtypes of PGE receptors, EP1, EP2, EP3, and EP4, were investigated in the mouse uterus during pseudopregnancy...
  65. pmc Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production
    A O Caggiano
    Committee on Neurobiology, University of Chicago, Illinois 60637, USA
    J Neurochem 72:565-75. 1999
    ..e., EP1, EP2, EP3, and EP4, expression and function in cultured rat microglia...
  66. ncbi Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice
    M P Akhter
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Bone 29:121-5. 2001
    ..The PGE2 influence on bone is mediated through four well-characterized receptors (EP1, EP2, EP3, and EP4)...
  67. ncbi Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids
    Bruno L Diaz
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1397-404. 2002
    ..by the E prostanoid (EP)1 receptor agonist 17-trinor-PGE(2), and the EP1/EP3 agonist, sulprostone, but not the EP2 receptor agonist, butaprost...
  68. ncbi [Pathophysiological roles of the prostanoids in the cardiovascular system: studies using mice deficient in prostanoid receptors]
    Akiyoshi Hara
    Department of Pharmacology, Asahikawa Medical College, Japan
    Nihon Yakurigaku Zasshi 122:384-90. 2003
    ..Moreover, EP receptors are classified into four subtypes, the EP1, EP2, EP3 and EP4 receptors...
  69. ncbi NaCl transport across the opercular epithelium of Fundulus heteroclitus is inhibited by an endothelin to NO, superoxide, and prostanoid signaling axis
    David H Evans
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Am J Physiol Regul Integr Comp Physiol 286:R560-8. 2004
    ..The Isc was stimulated by the EP2 agonist butaprost and inhibited by the EP(1,3) agonist sulprostone, suggesting both stimulatory and inhibitory PGE ..
  70. ncbi Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis
    Robert L Keith
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Denver VA Medical Center, Denver, CO 80220, USA
    Anticancer Res 26:2857-61. 2006
    ..Elevated PGI2 production prevents murine lung cancer, while decreasing PGE2 content protects against colon cancer. PGE2 receptor subtype 2 (EP2) -deficient mice were hypothesized to be resistant to lung tumorigenesis.
  71. doi Prostaglandin E2 negatively regulates AMP-activated protein kinase via protein kinase A signaling pathway
    Koji Funahashi
    Department of Endocrinology, Research Institute of Environmental Medicine RIEM, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Prostaglandins Other Lipid Mediat 88:31-5. 2009
    ..These effects of PGE2 were mimicked by PGE2 receptor EP2 and EP4 agonists and forskolin, but not by EP1 and EP3 agonists, and the effects were suppressed by an adenylate ..
  72. doi Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Fertil Steril 93:2498-506. 2010
    ..To determine interactions between prostaglandin (PG) E(2) signaling and proliferation of endometriotic cells to increase our knowledge about PGE(2) signaling in the pathogenesis of endometriosis in humans...
  73. doi Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood
    Theresa H Page
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 185:3694-701. 2010
    ..NSAID-mediated increases in TNF are reversed by either the addition of exogenous PGE(2) or by a PGE(2) EP2 receptor agonist, revealing that PGE(2) signaling via its EP2 receptor provides a valuable mechanism for ..
  74. doi A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord
    Shunji Kunori
    Department of Medical Chemistry, Kansai Medical University, Moriguchi, Japan
    Glia 59:208-18. 2011
    ..We further demonstrated that ATP-induced microglial migration was blocked in vitro by PGE(2) via EP2 and by S-nitrosoglutathione, an NO donor...
  75. doi C6orf176: a novel possible regulator of cAMP-mediated gene expression
    Armin Reitmair
    Department of Biological Sciences, Allergan Incorporated, Irvine, CA 92612, USA
    Physiol Genomics 44:152-61. 2012
    ..upon activation of the cAMP pathway in hCSM, using novel agonists highly selective for PGE(2) receptor subtypes EP2 or EP4, which are G protein-coupled receptors well known to activate cAMP signaling...
  76. pmc Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2
    Alastair J O'Brien
    Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, UK
    Nat Med 20:518-23. 2014
    ..cytokine secretion and bacterial killing in vitro in a PGE2-dependent manner via the prostanoid type E receptor-2 (EP2), effects not seen with plasma from patients with stable cirrhosis (Child-Pugh score grade A)...
  77. ncbi Comparison of the EP receptor subtypes mediating relaxation of the rabbit jugular and pig saphenous veins
    S A Milne
    Department of Pharmacology, University of Edinburgh, Scotland
    Prostaglandins 49:225-37. 1995
    ..Similar to the EP2 receptor, it mediates relaxation and is linked to stimulation of adenylate cyclase...
  78. ncbi Structure-function analyses of eicosanoid receptors. Physiologic and therapeutic implications
    R M Breyer
    Department of Medicine Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Ann N Y Acad Sci 905:221-31. 2000
    ..Recent studies on mice lacking the PGE2 EP2 receptor have implicated the PGE2 EP2 receptor subtype in arterial dilatation and salt-sensitive hypertension, and ..
  79. ncbi Regulation of growth and melanogenesis of uveal melanocytes
    D N Hu
    Tissue Culture Center, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York 10003, USA
    Pigment Cell Res 13:81-6. 2000
    ..endothelin, adrenergic beta2-receptor agonists, and some prostaglandins (EP2-receptor agonists and certain TP-receptor agonists) stimulate, while transforming growth factor-beta2, interleukin-..
  80. ncbi Pitfall of an internal control plasmid: response of Renilla luciferase (pRL-TK) plasmid to dihydrotestosterone and dexamethasone
    N M Ibrahim
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biotechniques 29:782-4. 2000
    ..While investigating hormone response elements in the promoters of the androgen-dependent, epididymis-specific EP2 gene, we found that hormone treatment affected the luciferase activity of pRL-TK-transfected cells...
  81. ncbi Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway
    Paul E Wolkowicz
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Prostaglandins Other Lipid Mediat 70:91-105. 2002
    ..In contrast, agonists for EP2, EP3, and EP4 caused little change in LA function...
  82. ncbi Prostaglandin E2 downregulates interleukin-12 production through EP4 receptors in human monocytes stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans and interferon-gamma
    K Iwasaki
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Microbiol Immunol 18:150-5. 2003
    ..actinomycetemcomitans-LPS/IFN-gamma-stimulated monocytes. Exogenous PGE2 inhibited IL-12 release in the cells. EP2, EP3 and EP4 receptor mRNA expression was detected in monocytes by reverse transcription-polymerase chain reaction...
  83. ncbi EP2 and EP4 prostanoid receptor signaling
    John W Regan
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721 0207, USA
    Life Sci 74:143-53. 2003
    ..This induction of EGR-1 expression has significant implications concerning the potential role of PGE(2) in cancer and inflammatory disorders...
  84. ncbi Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor
    Sung Hee Chang
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, 06030 3501, USA
    Prostaglandins Other Lipid Mediat 76:48-58. 2005
    ..Expression of the EP2 subtype of the PGE(2) receptor was correlated with the tumorigenic phenotype and the ability to induce vascular ..
  85. ncbi The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice
    Takashi Ota
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    Invest Ophthalmol Vis Sci 47:3395-9. 2006
    ..To determine the role of prostanoid EP receptors in the intraocular pressure (IOP)-lowering effect of prostaglandin analogues in EP receptor-deficient mice...
  86. pmc Therapeutic targets in prostaglandin E2 signaling for neurologic disease
    P J Cimino
    Division of Neuropathology, University of Washington School of Medicine, Box 359791, Harborview Medical Center, Seattle, WA 98104, USA
    Curr Med Chem 15:1863-9. 2008
    ..EP1 activation has been shown to mediate Ca2+-dependent neurotoxicity in ischemic injury. EP2 activation has been shown to mediate microglial-induced paracrine neurotoxicity as well as suppress microglia ..
  87. pmc Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates
    Christopher L Wright
    Program in Neuroscience, School of Medicine, University of Maryland Baltimore, MD, USA
    Dev Neurobiol 68:1406-19. 2008
    ..In female rats, neonatal treatment with antisense oligonucleotides against EP2 or EP4 but not EP1 or EP3 completely prevented the expression of adult behavior organized by PGE2 exposure...
  88. doi Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells
    Jung Min Oh
    Interdisciplinary Graduate Program in Tumor Biology, Cancer Research Institute, Seoul National University College of Medicine, Jongno gu, Seoul, Republic of Korea
    Carcinogenesis 30:141-9. 2009
    ..We conclude that the HPV16 E5 protein induces EP4 receptor protein in cervical cancer cells and that this induction involves epidermal growth factor receptor, COX-2, PGE2, EP2 and EP4, protein kinase A, CREB and CRE.
  89. doi Prostaglandin E2 modulates Na+,K+-ATPase activity in rat hippocampus: implications for neurological diseases
    Mauro Schneider Oliveira
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, RS, Brasil
    J Neurochem 109:416-26. 2009
    ..On the other hand, incubation with the selective EP2 agonist (butaprost, 0...
  90. ncbi Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells
    Fredika M Robertson
    Department of Experimental Therapeutics, 1515 Holcombe Blvd, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 7:299-312. 2008
    ..activity is to block binding of the PGE2 ligand to its prostanoid (EP) receptors, which are designated as EP1, EP2, EP3, and EP4 and are members of a subfamily of G protein coupled receptors (GPCRs)...
  91. doi Differential afferent sensitivity to mucosal lipopolysaccharide from Salmonella typhimurium and Escherichia coli in the rat jejunum
    C Y Liu
    Shandong University, Department of Physiology and Key Lab of Medical Neurobiology, School of Medicine, Shandong, China
    Neurogastroenterol Motil 21:1335-e129. 2009
    ..v.) or AH-6809 (EP1/EP2 receptor antagonist, 1 mg kg(-1)). Intestinal afferents do not alter their discharge rate to LPS from E...
  92. pmc Emerging roles of PGE2 receptors in models of neurological disease
    Katrin Andreasson
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Prostaglandins Other Lipid Mediat 91:104-12. 2010
    ..Further complexity is emerging, as exemplified by the PGE(2) EP2 receptor, where cerebroprotective or toxic effects of a particular prostaglandin signaling pathway can differ ..
  93. ncbi Single dose (400 mg) versus 7 day (200 mg) daily dose itraconazole in the treatment of tinea versicolor: a randomized clinical trial
    M A Wahab
    Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh
    Mymensingh Med J 19:72-6. 2010
    ..99%) and improvement 4(13.33%). (Here the End point EP2) equals to 93.33%. The EP clinical analysis however shows 91.66% response...
  94. pmc Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma
    Elizabeth M Poole
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 19:547-57. 2010
    ..Prostaglandins are metabolites of omega-6 and omega-3 polyunsaturated fatty acids; their biosynthesis is the primary target of nonsteroidal anti-inflammatory drugs (NSAID), which reduce colorectal neoplasia risk...
  95. pmc Comparative genomics identifies candidate genes for infectious salmon anemia (ISA) resistance in Atlantic salmon (Salmo salar)
    Jieying Li
    Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6
    Mar Biotechnol (NY) 13:232-41. 2011
    ..One gene in particular, HIV-EP2/MBP-2, caught our attention as it may influence the expression of several genes that have been implicated in the ..
  96. doi Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough
    Antonio Grilo
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz S N bNeocodex, Avda, Charles Darwin, Acc A Seville, Spain
    Pharmacogenet Genomics 21:10-7. 2011
    ..However, relatively little is known about the genetic susceptibility to ACEi-induced cough in hypertensive patients...
  97. pmc Prostaglandin E2 receptors are differentially expressed in subpopulations of granulosa cells from primate periovulatory follicles
    Siabhon M Harris
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Biol Reprod 85:916-23. 2011
    ..Cumulus cells expressed higher levels of EP2 and EP3 mRNA compared with mural cells 36 h after hCG...
  98. pmc Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus
    Emma T B Olesen
    Department of Biomedicine, Water and Salt Research Center, Aarhus University, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 108:12949-54. 2011
    ..In vitro, prostaglandin E2 (PGE2) and selective agonists for the E-prostanoid receptors EP2 (butaprost) or EP4 (CAY10580) all increased trafficking and ser-264 phosphorylation of AQP2 in Madin-Darby canine ..
  99. doi Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, USA
    Biol Reprod 87:97. 2012
    ..PGE(2) stimulated by pregnancy is transported locally to the ovary, which increases luteal PGE(2) biosynthesis and hence activates luteal PTGER2 and PTGER4 signaling, thus protecting the CL during the establishment of pregnancy in sheep.
  100. pmc Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A
    Jacob Kach
    From the Department of Medicine, University of Chicago, Chicago, Illinois 60637
    J Biol Chem 289:7505-13. 2014
    ..Finally, activation of PKA and the antifibrotic effect of noscapine in HLFs were blocked by the EP2 prostaglandin E2 receptor antagonist, PF-04418948, but not by the antagonists of EP4, prostaglandin D2, or ..
  101. doi Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor
    Mingzhan DU
    Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P R China
    Oncol Rep 34:715-26. 2015
    ..in cholangiocarcinoma cell proliferation, migration and invasion through E prostanoid receptors, including EP1, EP2 and EP4...

Research Grants70

  1. CYCLOOXYGENASE AND TUMORIGENESIS
    Daniel Hwang; Fiscal Year: 2003
    ..cells as compared with normal cells and to identify downstream signaling pathways of prostaglandin E receptor (Ep2)...
  2. IL-1nduced Mediators of CNS Inflammation and AD: PGE
    MICHAEL O BANION; Fiscal Year: 2006
    ..the influence of IL-1a on cell and tissue responses to PGE2, initially focusing on regulation and actions of the EP2 subtype of PGE2 receptor...
  3. Jianxiong Jiang; Fiscal Year: 2014
    ..pursued two major avenues of research 1) to develop small molecules that selectively modify prostaglandin receptor EP2, and 2) to determine how these compounds affect the pathologies in mouse models of epilepsy...
  4. SYLVAIN DORE; Fiscal Year: 2014
    ..our current working hypothesis is that PGE2 EP1 and EP3 receptors would promote ICH acute injury, whereas EP2 and EP4 receptors would promote neuroprotection after ICH...
  5. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..balance in BO development following second hit (ischemic, viral) injury, use genetic (COX, prostanoid receptor [EP2], and 5-LO deficient) and pharmacologic (COX and 5-LO inhibitor, LT receptor antagonist) strategies...
  6. Role of COX2 of Neuronal Origin in Blood-Brain Communication after status epilept
    Raymond J Dingledine; Fiscal Year: 2012
    ..leukocyte infiltration, microglial activation, and eventually epilepsy;and (2) To test the hypothesis that EP2 receptor activation on astrocytes or endothelial cells regulates albumin leakage and leukocyte infiltration across ..
  7. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..1 [BLT1]) and LTD4 (via cysteinyl LT receptor 1 [cysLT1]) promote, while PGE2 (via E prostanoid receptors 2 and 4 [EP2 and EP4]) inhibits, AM capacity for phagocytosis and killing of IgG-opsonized microbes...
  8. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..In recent studies, we have identified a central function of PGE2 signaling through its EP2 receptor in mediating inflammation, oxidative stress, and neurotoxicity...
  9. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
    ..The major prostaglandin (PG) product, PGE2, binds to one or more of the 4 EP receptors. EP2 and EP4 are linked to adenylate cyclase causing an increase in cAMP and subsequent activation of protein kinase A (..
  10. Regulation of PAF Acetylhydrolase Expression by Oxidized Phospholipids
    SUZANNE BARBOUR; Fiscal Year: 2009
    ..We hypothesize that long chain, prostaglandin-like oxPL induce PAFAH by binding to the CD14/ TLR4 complex and the EP2 prostaglandin receptor on dendritic cells in the developing atherosclerotic lesion...
  11. Cellular and Molecular Mechanisms of Inflammation in Alzheimer's Disease
    Nathaniel S Woodling; Fiscal Year: 2012
    ..Downstream of prostaglandin production, the PGE2 EP2 receptor may be a more specific molecular target in the search for strategies that prevent and reduce inflammation ..
  12. Role of COX-2 in UVB-induced beta-catenin signaling in keratinocytes
    Jill C Pelling; Fiscal Year: 2011
    ..primary mouse and human keratinocytes, as well as in mouse epidermis in vivo using COX-2+/- heterozygote mice and EP2-/- knockout mice and in human skin tumor samples...
  13. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2006
    ..1) to study mRNA and protein expression and localization for contractile FPI, EP1, EP3, and TP and relaxatory IP, EP2, and EP4 receptors in pregnant rat myometrium (day 16 to one day postpartum) and in pregnant animals with hormonal ..
  14. Tpl2 in Carcinogenesis-Related Inflammation
    KATHLEEN LEIGH DECICCO-SKINNER; Fiscal Year: 2011
    ..PGE2 binds to one of four G-protein linked receptors designated EP1, EP2, EP3, and EP4...
  15. CYCLOOXYGENASE AND PGE2 RECEPTOR FUNCTION IN SKIN CANCER
    Alice Pentland; Fiscal Year: 2004
    ..Our preliminary work demonstrates that primary human keratinocytes express both growth-stipulatory (EP2) and growth- inhibitory (EP3) receptors for prostaglandin E2 (PGE2) in significant amounts...
  16. MOLECULAR BASIS OF PRECONDITIONING
    Yiru Guo; Fiscal Year: 2005
    ..will be systematically interrogated by targeted genetic disruption of all known prostaglandin receptors (DP, EP1, EP2, EP3, EP4, F, and IP receptors)...
  17. Lipoic Acid Therapy for Experimental Autoimmune Encephalomyelitis
    DENNIS NEIL BOURDETTE; Fiscal Year: 2013
    ..the production of the small second molecule messenger cAMP via the prostaglandin G-coupled protein receptors EP2 and EP4...
  18. PROSTANOIDS IN COLON CANCER--CELL/MOLECULAR MECHANISMS
    James Roche; Fiscal Year: 1999
    ..now allow these issues to be addressed: 1) Procurement of sequence information/cloning of receptors for prostanoids EP2, EP3, EP4, IP, FP and TP; 2) A cDNA clone for a second (inducible) cyclo- oxygenase with potential importance in ..
  19. Chemopreventive effect of fish oil derived EPA in lung cancer
    Peiying Yang; Fiscal Year: 2013
    ..using the urethane-induced mouse lung cancer model with or without expression of EP receptor, particularly EP2 and EP4 receptors, will be further studied...
  20. Paul J Grippo; Fiscal Year: 2016
    ..and during disease progression along with specific molecular events (activation of Akt, effects of PGE3-bound EP2 on Akt activation, phosphorylation of various proteins like Akt, Foxo, and Bad,) will determine the mechanisms of ..
  21. HSCT-induced changes that impair lung innate immunity
    Bethany B Moore; Fiscal Year: 2012
    ..AMs from human HSCT patients overexpress COX-2 and PGE2 and have altered scavenger receptor profiles, the mechanisms by which this occurs and to test the therapeutic effect of cyclooxygenase or EP2 inhibition on innate immune function.
  22. Chung Owyang; Fiscal Year: 2016
    ..these abnormalities may be prevented by blockade of Toll-like receptor 4 signaling pathway or administration of EP2 receptor inhibitor, suggesting medication by prostaglandin evoked by LPS...
  23. Mechanisms for Dysfunctional HDL Formation in Familial Hypercholesterolemia
    Macrae F Linton; Fiscal Year: 2013
    ..receptors implicated in atherogenesis, including receptors for thromboxane (TP) and prostaglandin (PG)E2 (EP2)...
  24. Prostaglandin E2 Signaling in Growth and Pains of Endometriosis
    Joe A Arosh; Fiscal Year: 2012
    ..PGE2 produced at the site of inflammation acts on the nociceptors of peripheral terminals through EP1, EP2, EP3, and EP4 receptors by integrating multiple cell signaling pathways...
  25. PROSTANOID MEDIATED CYOPROTECTION
    Serrine Lau; Fiscal Year: 2001
    ..The cellular effects of PGE are receptor mediated and four PGE receptors (EP) have been identified and termed EP 1, EP2, EP3, and EP4...
  26. EP2 Allosteric Potentiators for Subarachnoid Hemorrhage
    Raymond J Dingledine; Fiscal Year: 2012
    ..b>EP2 receptor activation has been shown to be neuroprotective in several animal models of acute cerebral ischemia...
  27. TANYA MARIA LAIDLAW; Fiscal Year: 2016
    ..that platelets from individuals with AERD demonstrate decreased function of two prostaglandin E2 receptors, EP2 and EP4, which lowers the threshold for activation of their platelets and allows for increased platelet adhesion ..
  28. SURAJ SUNIL PRADHAN; Fiscal Year: 2014
    ..prostaglandin E2 (PGE2) can regulate innate immune responses in the brain via the pro- inflammatory receptor EP2 and anti-inflammatory receptor EP4...
  29. Molecular Basis of Treating Endometriosis by Prostaglandin E2 Receptor Inhibitors
    Joe A Arosh; Fiscal Year: 2012
    ..Our central hypothesis is that loss-of-function of PGE2 receptors EP2 and EP4 inhibits survival and growth of endometriosis...
  30. E-Prostanoid Receptor Subtype 2 (EP2) Regulation of Microglial Activation
    Patrick J Cimino; Fiscal Year: 2011
    ..Recently we demonstrated that genetic ablation of the EP2 receptor from primary mouse microglia resulted in the highly desirable dual phenotype of an increase in ..
  31. Richard M Breyer; Fiscal Year: 2014
    ..Our working hypothesis is that blockade of both the EP1 and EP3 receptors while leaving the EP2 and EP4 receptor response intact will be protective in settings of renal disease and may be more beneficial than ..
  32. Epigenetic Regulation of the E Prostanoid 2 Receptor Gene in Lung Fibroblasts
    Steven K Huang; Fiscal Year: 2013
    ..What is unclear is how EP2 expression is lost in these cells...
  33. Vassiliki A Boussiotis; Fiscal Year: 2016
    ..In UCB T cells PGE2 modified the Wnt signaling cascade through EP2/EP4 receptors and cAMP-mediated phosphorylation of Gsk3, resulting in stabilization of [unreadable]-catenin and TCF-..
  34. PG's and Keratinocyte Adhesion
    Sabine M Brouxhon; Fiscal Year: 2013
    ..Moreover, the candidate has discovered that this process is regulated by activation of the EP2 receptor by PGE2 released locally after UV radiation injury...
  35. Joshua A Boyce; Fiscal Year: 2016
    ..These abnormalities result in failure of the prostaglandin (PG)E2-EP2 receptor system to control the synthesis and effector actions of cysteinyl leukotrienes (cys-LTs)...
  36. The role of E-cadherin in photocarcinogenesis
    Sabine M Brouxhon; Fiscal Year: 2010
    ..since we recently demonstrated that inhibition of PGE2 synthesis by indomethacin in vitro, targeted deletion of EP2 in primary mouse keratinocyte (PMK) cultures or deletion of the EP2 receptor in vivo or in vitro abrogated this UV-..
  37. ELAINE EMILY WIRRIG; Fiscal Year: 2014
    ..In bone, COX2 catalyzes the first committed step in the synthesis of prostaglandin E2, which signals via the EP2 receptor to phosphorylate p-38 MAPK, which subsequently activates an osteogenic pathway necessary for new bone ..
  38. Role of PGE2 receptors in the aging brain after intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2012
    ..We hypothesize that PGE2 EP1 and EPS receptors promote acute brain injury, whereas EP2 and EP4 receptors promote neuroprotection after ICH. Three specific aims will test our hypothesis...
  39. Raymond J Dingledine; Fiscal Year: 2015
    ..We have evidence that activation of brain EP2 receptors can be neuroprotective after status epilepticus...
  40. Joshua A Boyce; Fiscal Year: 2016
    ..We have also found that platelets and leukocytes from individuals with AERD lack the EP2 receptor for PGE2...
  41. Molecular Mechanism of PGE2 Receptor Pressor Effects
    Richard M Breyer; Fiscal Year: 2011
    ..The EP1 and EP3 receptors primarily mediate the pressor response, while the EP2 and EP4 receptors mediate the depressor response...
  42. PROSTAGLANDINS AND GASTROINTESTINAL DNA DAMAGE
    Courtney Houchen; Fiscal Year: 2006
    ..The EP receptors are encoded by four separate genes (EP1, EP2, EP3 and EP4). These receptors differ in their ligand binding specificity and in down stream signaling pathways...
  43. Adenylyl cyclases in airway and GI smooth muscle
    Rennolds S Ostrom; Fiscal Year: 2010
    ..cAMP formation and relaxation but not increased basal cAMP levels or response to activation of prostaglandin EP2 receptors...
  44. REGULATED POLYADENYLATION OF MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2004
    ..with PLE like elements and this investigator demonstrated the functionality of the PLE in the gene encoding the HIV-EP2/Schnurri 2, a zinc finger transcription factor that activates transcription of the integrated HIV-1 provirus...
  45. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We will test the hypothesis that PGE2 acts via EP1 and EP2 receptor subtypes to stimulate both PKC and PKA pathways, which induce P450arom expression...
  46. PGE2 in the Pathogenesis of Allergic Airway Disease
    Beverly Koller; Fiscal Year: 2009
    ..we showed that activation of the EP1 and EP3 receptors by PGE2 leads to airway obstruction, while activation of the EP2 receptor protected against methacholine-induced bronchoconstriction...
  47. Genetic Study of Prostaglandin Synthesis/EGFR and Risk of Colorectal Neoplasia
    Cornelia Ulrich; Fiscal Year: 2007
    ..PGES) and 15- hydroxyprostaglandin dehydrogenase (PGDN); b) bind to PGE2 at the cell surface (receptors EP1, EP2, and EP4); or c) are involved in PGE2 cross-talk with EGFR signaling (Src and EGFR)...
  48. MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASE
    WILLIAM STENSON; Fiscal Year: 2006
    ..have developed data suggesting that the effects of PGE2 on these events in mice are mediated through binding to the EP2 receptor...
  49. PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMS
    Lu Yuan Lee; Fiscal Year: 2005
    ..of this study is that endogenous PGE2 increases the sensitivity of the pulmonary C-fiber endings by activating EP2 and/or EP4 prostanoid receptors; activation of these EP receptors enhances the neuronal excitability by activating ..
  50. Modulation of Lung Innate Immunity Prostaglandin E2
    David Aronoff; Fiscal Year: 2009
    ..effects changes in cell functions through ligation of four distinct G-protein coupled E-prostanoid receptors (EP1, EP2, EP3 and EP4)...
  51. PROSTAGLANDIN E2 RECEPTORS IN GASTROINTESTINAL INJURY
    Courtney Houchen; Fiscal Year: 2004
    ..The EP receptors are encoded by four separate genes (EPI, EP2, EP3, and EP4 )...
  52. Functional Analysis of the Prostaglandin EP3 Receptor
    Richard Breyer; Fiscal Year: 2005
    ..of PGE2's effects are mediated via specific guanine nucleotide regulatory protein coupled receptors designated EP1, EP2, EP3, and EP4...
  53. Proteomic Discovery in Parkinson-Dementia Complex of Guam
    Thomas Montine; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  55. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2007
    ..abstract_text> ..
  56. Characterization of Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2007
    ..This resource will be made available for future investigations of DLB. ..
  57. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2004
    ....
  58. ROLE OF PROTEIN KINASES IN TRANSPORT REGULATION
    Mary Taub; Fiscal Year: 2004
    ..The possible involvement of an inhibitory phosphatase, in regulating the phosphorylation of the Na,K-ATPase will also be examined. ..
  59. Regulation of DC Activity by Memory and Effector CD8+ T Cells
    Pawel Kalinski; Fiscal Year: 2010
    ..abstract_text> ..
  60. SOLUABLE POLYMER SUPPORTS FOR ORGANIC SYNTHESIS
    Kim Janda; Fiscal Year: 2001
    ..It is anticipated that soluble-polymer supports will finding increasing utility in synthesis in the coming years. ..
  61. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  62. Interstitial Cell COXs in Renal Development and Disease
    Chuan Ming Hao; Fiscal Year: 2004
    ....
  63. Mechanisms of Nicotine Induced Neurogenic Inflammation
    Kenneth Hargreaves; Fiscal Year: 2005
    ....
  64. Regulation of Angiogenesis via EphB4 Signaling
    JENA STEINLE; Fiscal Year: 2002
    ..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
  65. Role of Cyclooxygenase stimulated Neovascularization in Diabetic Nephropathy
    Chuan Ming Hao; Fiscal Year: 2008
    ..Pozzi's expertise in angiogenesis and Dr. Breyer's expertise in mouse models of diabetic nephropathy, and draws on their common interest in the prostanoid pathway in cell differentiation and survival. ..
  66. Regulation and actions of NO in the cardiac plexus
    JEAN HARDWICK; Fiscal Year: 2005
    ..In particular, it will provide important information concerning the regulation and of NO in the control of cardiac function. ..
  67. FACTORS INFLUENCING BONE METABOLISM
    Lawrence Raisz; Fiscal Year: 2008
    ..Our studies will focus on the role of EP2 and EP4 receptors (EP2R and EP4R)...
  68. MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
    Anthony Blikslager; Fiscal Year: 2002
    ..These experiments will provide insight into the signaling pathways and mechanisms by which prostaglandins trigger repair of acutely-injured intestinal epithelium. ..