PTGDS

Summary

Gene Symbol: PTGDS
Description: prostaglandin D2 synthase
Alias: L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2, prostaglandin-H2 D-isomerase, PGD2 synthase, beta-trace protein, cerebrin-28, glutathione-independent PGD synthase, glutathione-independent PGD synthetase, lipocalin-type prostaglandin D synthase, prostaglandin D synthase, prostaglandin D2 synthase 21kDa (brain), testis tissue sperm-binding protein Li 63n
Species: human
Products:     PTGDS

Top Publications

  1. Hoffmann A, Conradt H, Gross G, Nimtz M, Lottspeich F, Wurster U. Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase. J Neurochem. 1993;61:451-6 pubmed
    ..from a cDNA clone isolated by other investigators allowed the identification of beta-trace protein as prostaglandin D synthase [prostaglandin-H2 D-isomerase; (5Z, 13E)-(15S)-9 alpha, 11 alpha-epidioxy-15-hydroxyprosta-5,13-dienoate ..
  2. Blödorn B, Mader M, Urade Y, Hayaishi O, Felgenhauer K, Bruck W. Choroid plexus: the major site of mRNA expression for the beta-trace protein (prostaglandin D synthase) in human brain. Neurosci Lett. 1996;209:117-20 pubmed
    Expression of beta-trace protein (beta-trace), recently identified as glutathion-independent prostaglandin D synthase (prostaglandin-H2 D-isomerase; EC 5.3.99...
  3. White D, Takeda T, DeGroot L, Stefansson K, Arnason B. Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. J Biol Chem. 1997;272:14387-93 pubmed
    ..We have shown that a gene active in the choroid plexus and meninges is responsive to T3. T3 may play a role in the regulated transport of substances into the cerebrospinal fluid and ultimately the brain. ..
  4. Eguchi Y, Eguchi N, Oda H, Seiki K, Kijima Y, Matsu Ura Y, et al. Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. Proc Natl Acad Sci U S A. 1997;94:14689-94 pubmed
    Lipocalin-type prostaglandin D synthase (L-PGDS) is localized in the central nervous system and male genital organs of various mammals and is secreted as beta-trace into the closed compartment of these tissues separated from the systemic ..
  5. Tokugawa Y, Kunishige I, Kubota Y, Shimoya K, Nobunaga T, Kimura T, et al. Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. Biol Reprod. 1998;58:600-7 pubmed
    b>Prostaglandin D synthase (PGDS) activity was detected in human seminal plasma (0.05-1.83 nmol/min per milligram protein)...
  6. Pinzar E, Kanaoka Y, Inui T, Eguchi N, Urade Y, Hayaishi O. Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A. 2000;97:4903-7 pubmed
    To examine the function of prostaglandin (PG) D synthase (PGDS) gene, as well as endogenously produced PGD(2) in sleep regulation in vivo, we generated transgenic (TG) mice that overexpress human PGDS gene to study their sleep behavior...
  7. Hirawa N, Uehara Y, Ikeda T, Gomi T, Hamano K, Totsuka Y, et al. Urinary prostaglandin D synthase (beta-trace) excretion increases in the early stage of diabetes mellitus. Nephron. 2001;87:321-7 pubmed
    Circulating levels of lipocalin-type prostaglandin D synthase (L-PGDS)/beta-trace reportedly increase in renal failure as well as in cardiovascular injuries...
  8. Hirawa N, Uehara Y, Yamakado M, Toya Y, Gomi T, Ikeda T, et al. Lipocalin-type prostaglandin d synthase in essential hypertension. Hypertension. 2002;39:449-54 pubmed
    Lipocalin-type prostaglandin D synthase (L-PGDS) reportedly well predicts cardiovascular injuries in humans. However, little is known about the implications of L-PGDS in hypertension...
  9. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, et al. Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Nat Struct Biol. 2003;10:291-6 pubmed
    ..Using GSH as a cofactor, prostaglandin D synthase catalyzes the isomerization of PGH2 to PGD2, a mediator for allergy response...

More Information

Publications119 found, 100 shown here

  1. Miwa Y, Oda H, Shiina Y, Shikata K, Tsushima M, Nakano S, et al. Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects. Hypertens Res. 2008;31:1931-9 pubmed publisher
    Recent studies suggest that lipocalin-type prostaglandin (PG) D synthase (L-PGDS), which converts PGH2 to PGD2, is implicated in the pathogenesis of atherosclerosis...
  2. Nagata A, Suzuki Y, Igarashi M, Eguchi N, Toh H, Urade Y, et al. Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. Proc Natl Acad Sci U S A. 1991;88:4020-4 pubmed
    cDNAs for glutathione-independent prostaglandin D synthase were isolated from cDNA libraries of human brain...
  3. Fujitani Y, Kanaoka Y, Aritake K, Uodome N, Okazaki Hatake K, Urade Y. Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. J Immunol. 2002;168:443-9 pubmed
    ..These results indicate that PGD(2) plays an important role in late phase allergic reactions in the pathophysiology of bronchial asthma. ..
  4. Fujimori K, Aritake K, Urade Y. Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. Gene. 2008;426:72-80 pubmed publisher
    ..was induced through transcriptional activation of cyclooxygenase (COX)-2 and lipocalin-type PGD synthase (L-PGDS) genes under serum-starved conditions in human brain-derived TE671 cells...
  5. Zhou Y, Shaw N, Li Y, Zhao Y, Zhang R, Liu Z. Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules. FASEB J. 2010;24:4668-77 pubmed publisher
    Human prostaglandin D synthase (L-PGDS) is a lipocalin-type enzyme involved in the metabolism of arachidonic acid and plays a key role in the regulation of sleep, allergy, pain sensation, and the development of male reproductive organs...
  6. Mathurin K, Gallant M, Germain P, Allard Chamard H, Brisson J, Iorio Morin C, et al. An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. J Biol Chem. 2011;286:2696-706 pubmed publisher
    L-type prostaglandin synthase (L-PGDS) produces PGD(2), a lipid mediator involved in neuromodulation and inflammation...
  7. Miyagi M, Miwa Y, Takahashi Yanaga F, Morimoto S, Sasaguri T. Activator protein-1 mediates shear stress-induced prostaglandin d synthase gene expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2005;25:970-5 pubmed
    We attempted to determine the molecular mechanism of fluid shear stress-induced lipocalin-type prostaglandin D synthase (l-PGDS) expression in vascular endothelial cells...
  8. Qu W, Huang Z, Xu X, Aritake K, Eguchi N, Nambu F, et al. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci U S A. 2006;103:17949-54 pubmed
    ..intracerebroventricular administration of selenium tetrachloride (SeCl4), a selective inhibitor of PGD synthase (PGDS), was shown to reduce promptly and effectively the amounts of sleep during the period of infusion...
  9. Kanekiyo T, Ban T, Aritake K, Huang Z, Qu W, Okazaki I, et al. Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid. Proc Natl Acad Sci U S A. 2007;104:6412-7 pubmed
    ..Here we reported that lipocalin-type prostaglandin D synthase (L-PGDS)/beta-trace, the most abundant cerebrospinal fluid (CSF) protein produced in the brain, was ..
  10. Inoue T, Eguchi Y, Matsumoto T, Kijima Y, Kato Y, Ozaki Y, et al. Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. Atherosclerosis. 2008;201:385-91 pubmed publisher
    Lipocalin-type prostaglandin D synthase (L-PGDS), which is responsible for the biosynthesis of prostaglandin (PG) D(2), has been found to be present in the atherosclerotic plaque of the human coronary artery and also to be detectable in ..
  11. Yagami T, Koma H, Yamamoto Y. Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. Mol Neurobiol. 2016;53:4754-71 pubmed publisher
    ..b>PGD2, PGE2, and PGI2 exhibit neuroprotective effects via Gs-coupled DP1, EP2/EP4, and IP receptors, respectively...
  12. Li X, Yang J, Jin Y, Jin F, Kim D, Chang J, et al. 15,16-Dihydrotanshinone I suppresses IgE-Ag stimulated mouse bone marrow-derived mast cell activation by inhibiting Syk kinase. J Ethnopharmacol. 2015;169:138-44 pubmed publisher
    ..inflammatory effects of DHT-I on degranulation and on the generation of eicosanoids, such as, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4), in IgE/Ag-stimulated bone marrow-derived mast cells (BMMCs)...
  13. Targovnik H, Citterio C, Rivolta C. Iodide handling disorders (NIS, TPO, TG, IYD). Best Pract Res Clin Endocrinol Metab. 2017;31:195-212 pubmed publisher
    ..transporters located either in the basolateral or apical membranes, sodium iodide symporter (NIS) and pendrin (PDS), respectively...
  14. Zanatta A, de Carvalho B, Amaral K, Polcheira P, de Sousa J, Zaconeta A. Laparoscopic interval isthmocervical cerclage with cardiac tape in a patient with previous cervical amputation. J Minim Invasive Gynecol. 2015;22:536-7 pubmed publisher
    ..Finally, we closed the visceral peritoneum with a 3-0 PDS running suture (Ethicon). The surgery lasted 70 minutes, and bleeding was minimal...
  15. Huang C, Jap T. A systematic review of genetic studies of thyroid disorders in Taiwan. J Chin Med Assoc. 2015;78:145-53 pubmed publisher
    ..2268insT in the thyroid peroxidase (TPO) gene and c.919-2A>G in the Pendred syndrome (PDS) gene...
  16. Dossena S, Nofziger C, Tamma G, Bernardinelli E, Vanoni S, Nowak C, et al. Molecular and functional characterization of human pendrin and its allelic variants. Cell Physiol Biochem. 2011;28:451-66 pubmed publisher
    Pendrin (SLC26A4, PDS) is an electroneutral anion exchanger transporting I(-), Cl(-), HCO(3)(-), OH(-), SCN(-) and formate...
  17. Xu T, Jin H, Lao Y, Wang P, Zhang S, Ruan H, et al. Administration of erythropoietin prevents bone loss in osteonecrosis of the femoral head in mice. Mol Med Rep. 2017;16:8755-8762 pubmed publisher
    ..ONFH was established by the administration prednisolone (PDS, 100 mg/kg) with co?treatment of lipopolysaccharide (LPS, 1 mg/kg)...
  18. Xue S, He J, Zhang X, Liu Y, Xue F, Wang C, et al. Metabolomic analysis revealed the role of DNA methylation in the balance of arachidonic acid metabolism and endothelial activation. Biochim Biophys Acta. 2015;1851:1317-26 pubmed publisher
    ..COX) pathway, were significantly increased by 5-AZA treatment in ECs resulting from the induction of PGD2 synthase (PTGDS) and thromboxane A synthase 1 (TBXAS1) expression by DNA hypomethylation...
  19. Holen E, Araujo P, Sissener N, Rosenlund G, Waagbø R. A comparative study: Difference in omega-6/omega-3 balance and saturated fat in diets for Atlantic salmon (Salmo salar) affect immune-, fat metabolism-, oxidative and apoptotic-gene expression, and eicosanoid secretion in head kidney leukocytes. Fish Shellfish Immunol. 2018;72:57-68 pubmed publisher
    ..4) also upregulated tumor necrosis factor alpha (tnf-?), cyclooxygenase (cox2), prostaglandin D and E synthase (ptgds, ptges), fatty acyl synthase (fas), 5 and 6 desaturases (5des, 6 des) and a fatty acid translocase protein (cd36) ..
  20. Shin D, Park S, Choi Y, Kim Y, Antika L, Habibah N, et al. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015;16:29980-95 pubmed publisher
    ..M suppressed β-hexosaminidase release and cyclooxygenase 2 (COX2)-mediated production of prostaglandin D2 (PGD2) and prostaglandin F2α (PGF2α) in sensitized mast cells...
  21. Moros Nicolás C, Fouchécourt S, Goudet G, Monget P. Genes Encoding Mammalian Oviductal Proteins Involved in Fertilization are Subjected to Gene Death and Positive Selection. J Mol Evol. 2018;86:655-667 pubmed publisher
    ..endometrial protein (PAEP) in tarsier, mouse, rat, rabbit, dolphin, and megabat; prostaglandin D2 synthase (PTGDS) in microbat; and plasminogen (PLG) in megabat...
  22. White C, Ghazan Shahi S, Adams M. β-Trace protein: a marker of GFR and other biological pathways. Am J Kidney Dis. 2015;65:131-46 pubmed publisher
    Trace protein (BTP), also known as lipocalin prostaglandin D2 synthase (L-PGDS; encoded by the PTGDS gene), is a low-molecular-weight glycoprotein and an emerging novel marker of glomerular filtration rate...
  23. Debray García Y, Sanchez E, Rodríguez Muñoz R, Venegas M, Velazquez J, Reyes J. Diabetes and exposure to peritoneal dialysis solutions alter tight junction proteins and glucose transporters of rat peritoneal mesothelial cells. Life Sci. 2016;161:78-89 pubmed publisher
    ..rat peritoneal mesothelial cells (RPMC) from diabetic rats and after treatment with peritoneal dialysis solutions (PDS) in vitro. Diabetes was induced in female Wistar rats by streptozotocin (STZ)-injection...
  24. Chen Y, Du Y, Li Y, Wang X, Gao P, Yang G, et al. Panaxadiol Saponin and Dexamethasone Improve Renal Function in Lipopolysaccharide-Induced Mouse Model of Acute Kidney Injury. PLoS ONE. 2015;10:e0134653 pubmed publisher
    ..Previous studies showed that panaxadiol saponin (PDS) and Dexamethasone have similar anti-inflammatory properties and protect cardiopulmonary function in ..
  25. Martin Vaquero P, da Costa R, Allen M, Moore S, Keirsey J, Green K. Proteomic analysis of cerebrospinal fluid in canine cervical spondylomyelopathy. Spine (Phila Pa 1976). 2015;40:601-12 pubmed publisher
    ..The knowledge of the protein changes that occur in CSM and upon corticosteroid treatment of CSM-affected patients will aid in further understanding the pathomechanisms underlying this disease. N/A. ..
  26. Wu J, Huang D, Su X, Yan H, Sun Z. Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D2 synthase expression in adult rats. Toxicol Ind Health. 2015;: pubmed
    ..polymerase chain reaction analyses showed that BPA induced upregulation of prostaglandin D2 synthase (Ptgds), Fas, Pbef1, and complement factor B (Cfb)as well as downregulation of Pttg1 and Fabp4 in the VP...
  27. Li W, Malpica Llanos T, Gundry R, Cotter R, Sacktor N, McArthur J, et al. Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity. Neurology. 2008;70:1753-62 pubmed
    ..and identified by tandem mass spectrometry, and the functional consequence of 3-NT modification of L-prostaglandin D synthase (L-PGDS), the most abundant protein, was determined...
  28. Clotault J, Peltier D, Soufflet Freslon V, Briard M, Geoffriau E. Differential selection on carotenoid biosynthesis genes as a function of gene position in the metabolic pathway: a study on the carrot and dicots. PLoS ONE. 2012;7:e38724 pubmed publisher
    ..Evolutionary rates of seven genes distributed along the carotenoid biosynthesis pathway, IPI, PDS, CRTISO, LCYB, LCYE, CHXE and ZEP, were compared in seven dicot taxa...
  29. Rozenshtein A, Heitkamp D, Muhammed T, Sclamberg J, Paladin A, Smith S, et al. "What Program Directors Think" III: Results of the 2014/2015 Annual Surveys of the Association of Program Directors in Radiology (APDR). Acad Radiol. 2016;23:861-9 pubmed publisher
    ..The maximal response rate was 33% in the fall of 2014 and 36% in the spring of 2015. PDs believed that the radiology Milestones, now largely implemented, did not affect overall resident evaluation, was ..
  30. Müller Engelmann M, Steil R. Cognitive restructuring and imagery modification for posttraumatic stress disorder (CRIM-PTSD): A pilot study. J Behav Ther Exp Psychiatry. 2017;54:44-50 pubmed publisher
    ..Self-ratings, e.g., the Posttraumatic Diagnostic Scale (PDS) and the Posttraumatic Cognitions Inventory (PTCI), were administered at baseline, immediately posttreatment, and ..
  31. Müssle B, Wierick A, Distler M, Weitz J, Welsch T. Falciform ligament wrap for prevention of gastroduodenal artery bleed after pancreatoduodenectomy. J Surg Res. 2017;207:215-222 pubmed publisher
    ..At the own center, a falciform ligament wrap was performed in 39 of 196 PDs (20%)...
  32. Grant B, Stinson F, Dawson D, Chou S, Ruan W. Co-occurrence of DSM-IV personality disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Compr Psychiatry. 2005;46:1-5 pubmed
    ..and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision ( DSM-IV-TR ) personality disorders (PDs) in the US population...
  33. Gemmecker S, Schaub P, Koschmieder J, Brausemann A, Drepper F, Rodriguez Franco M, et al. Phytoene Desaturase from Oryza sativa: Oligomeric Assembly, Membrane Association and Preliminary 3D-Analysis. PLoS ONE. 2015;10:e0131717 pubmed publisher
    Recombinant phytoene desaturase (PDS-His6) from rice was purified to near-homogeneity and shown to be enzymatically active in a biphasic, liposome-based assay system. The protein contains FAD as the sole protein-bound redox-cofactor...
  34. Abrie J, Molero C, Ariño J, Strauss E. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Sci Rep. 2015;5:15774 pubmed publisher
    ..The PPCDC domains (PDs) of Hal3, Vhs3 and Cab3 constitute the minimum requirement for these proteins to show both PPCDC activity and, in ..
  35. Liu C, Wang K, Gong X, Heeger A. Low bandgap semiconducting polymers for polymeric photovoltaics. Chem Soc Rev. 2016;45:4825-46 pubmed publisher
    ..While for ultrasensitive photodetectors (PDs), which have intensive applications in both scientific and industrial sectors, sensing from the UV to the NIR ..
  36. Wang H, Movshon J. Properties of pattern and component direction-selective cells in area MT of the macaque. J Neurophysiol. 2016;115:2705-20 pubmed publisher
    ..direction-selective, CDS); others respond to the true direction of complex patterns (pattern-direction selective, PDS)...
  37. Wang Y, Gao B, Wang F, Liu S, Yu H, Zhang W, et al. Palladium(ii) and palladium(ii)-silver(i) complexes with N-heterocyclic carbene and zwitterionic thiolate mixed ligands: synthesis, structural characterization and catalytic properties. Dalton Trans. 2017;46:1832-1839 pubmed publisher
    ..an edge-fused norbornane-like (Pd2Ag4S6) framework appended by two additional PdS2 motifs at the polar positions. Compounds 5 and 6 also feature PdPd (5), PdAg and AgAg (6) interactions...
  38. Szymanowski F, Hugo A, Alves P, Simões P, Gomez Zavaglia A, Perez P. Endocytosis and intracellular traffic of cholesterol-PDMAEMA liposome complexes in human epithelial-like cells. Colloids Surf B Biointerfaces. 2017;156:38-43 pubmed publisher
    ..In this work, we demonstrated an efficient uptake of LC CHO-PDs by human epithelial-like cells (HEK-293) through the non-degradative caveolae endocytic pathway...
  39. Macedo F, Jayanthi P, Mowzoon M, Yakoub D, Dudeja V, Merchant N. The Impact of Surgeon Volume on Outcomes After Pancreaticoduodenectomy: a Meta-analysis. J Gastrointest Surg. 2017;21:1723-1731 pubmed publisher
    ..Eleven studies met the inclusion criteria comprising 36,449 patients. Among these patients, 12,512 (34.3%) PDs were performed by HVS and 23,937 (65.7%) by LVS...
  40. Kaneko A, Uenishi K, Maruyama Y, Mizuno N, Baba S, Kumasaka T, et al. A solute-binding protein in the closed conformation induces ATP hydrolysis in a bacterial ATP-binding cassette transporter involved in the import of alginate. J Biol Chem. 2017;292:15681-15690 pubmed publisher
    ..into liposomes with AlgQ2 and alginate oligosaccharide substrates having different polymerization degrees (PDs)...
  41. Sun W, An Z, Wu P. Revealing the distinct thermal transition behavior between PEGA-based linear polymers and their disulfide cross-linked nanogels. Phys Chem Chem Phys. 2017;19:25746-25753 pubmed publisher
    ..The C-H groups in the pyridyl disulfide (PDS) units exhibit a distinct change in the thermoresponsive profile of the precursor and the nanogel to show the ..
  42. Elklit A, Murphy S, Jacobsen C, Jensen M. Clinical and Personality Disorders in a Danish Treatment-Seeking Sample of Intimate Partner Violence Perpetrators. Int J Offender Ther Comp Criminol. 2018;62:3322-3336 pubmed publisher
    ..There was significant variation in the prevalence of clinical disorders and PDs, with Antisocial PD and Anxiety Disorder being the most common...
  43. Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, et al. Prostaglandin D2 metabolite in urine is an index of food allergy. Sci Rep. 2017;7:17687 pubmed publisher
    ..presented with increased numbers of intestinal mast cells, which strongly expressed hematopoietic PGD synthase (H-PGDS). The levels of urinary tetranor-PGDM increased as the disease progressed...
  44. Fajmut A, Emeršič T, Dobovišek A, Antić N, Schäfer D, Brumen M. Dynamic model of eicosanoid production with special reference to non-steroidal anti-inflammatory drug-triggered hypersensitivity. IET Syst Biol. 2015;9:204-15 pubmed publisher
    ..The model focuses on two PGs (PGE2 and PGD2) and one LT (LTC4), their % increases and their ratios...
  45. Arcaro J, Ma J, Chu L, Kuo M, Mirsattari S, Stan Leung L. The hippocampus participates in a pharmacological rat model of absence seizures. Epilepsy Res. 2016;120:79-90 pubmed publisher
    ..5-6 Hz paroxysmal discharges (PDs) induced by GBL were synchronized among the thalamocortical system and the hippocampus, and whether inactivation of ..
  46. Vizzielli G, Costantini B, Tortorella L, Pitruzzella I, Gallotta V, Fanfani F, et al. A laparoscopic risk-adjusted model to predict major complications after primary debulking surgery in ovarian cancer: A single-institution assessment. Gynecol Oncol. 2016;142:19-24 pubmed publisher
    ..a simple adjusted laparoscopic score to predict major postoperative complications after primary debulking surgery (PDS) in advanced epithelial ovarian cancer (AEOC)...
  47. Rossi S, Windschüttl S, Matzkin M, Rey Ares V, Terradas C, Ponzio R, et al. Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells. Mol Cell Endocrinol. 2016;434:154-65 pubmed publisher
    ..We previously described a prostaglandin D2 (PGD2) system in Sertoli cells...
  48. Sagawa Y, Sato M, Sakai N, Chikahisa S, Chiba S, Maruyama T, et al. Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice. Neuropharmacology. 2016;110:268-276 pubmed publisher
    Prostaglandin (PG)D2 is an endogenous sleep substance, and a series of animal studies reported that PGD2 or PGD2 receptor (DP1) agonists promote sleep, while DP1 antagonists promote wakefulness...
  49. Lee C, Tsai M, Lin C, Strong C. Longitudinal Effects of Self-Report Pubertal Timing and Menarcheal Age on Adolescent Psychological and Behavioral Outcomes in Female Youths from Northern Taiwan. Pediatr neonatol. 2017;58:313-320 pubmed publisher
    ..Subjective PT was defined using the Pubertal Developmental Scale (PDS), which mainly measures pubertal changes. MA was recalled by participants themselves...
  50. Mentessidou A, Saxena A. Laparoscopic Repair of Duodenal Atresia: Systematic Review and Meta-Analysis. World J Surg. 2017;41:2178-2184 pubmed publisher
    ..The complications and conversions rates of LRDA were not affected by the different suture materials (Silk, Vicryl, PDS; p = 0.51) or suturing technique (interrupted, continuous; p = 0.46)...
  51. Reichborn Kjennerud T, Krueger R, Ystrom E, Torvik F, Rosenström T, Aggen S, et al. Do DSM-5 Section II personality disorders and Section III personality trait domains reflect the same genetic and environmental risk factors?. Psychol Med. 2017;47:2205-2215 pubmed publisher
    DSM-5 includes two conceptualizations of personality disorders (PDs). The classification in Section II is identical to the one found in DSM-IV, and includes 10 categorical PDs...
  52. Mariathas M, Gemmell C, Olechowski B, Nicholas Z, Mahmoudi M, Curzen N. High sensitivity troponin in the management of tachyarrhythmias. Cardiovasc Revasc Med. 2018;19:487-492 pubmed publisher
    ..Patient mortality status was recorded through the Personal Demographics Service (PDS) via NHS Digital. A total of 704 patients were eligible for inclusion to the study...
  53. Hoburg A, von Roth P, Roy Ali S, Ode J, Wulsten D, Jung T, et al. Biomechanical performance of the Actifit® scaffold is significantly improved by selection of irrigation fluid. Arch Orthop Trauma Surg. 2018;138:537-542 pubmed publisher
    ..We compared two different suture materials-polydioxanone (PDS) and non-absorbable, braided polyester sutures (NABP)-as well as two common irrigation fluids-lactated Ringer's and ..
  54. Hiraoka A, Seiki K, Oda H, Eguchi N, Urade Y, Tominaga I, et al. Charge microheterogeneity of the beta-trace proteins (lipocalin-type prostaglandin D synthase) in the cerebrospinal fluid of patients with neurological disorders analyzed by capillary isoelectrofocusing. Electrophoresis. 2001;22:3433-7 pubmed
    Charge microheterogeneity of the beta-trace protein (beta-TP = lipocalin-type prostaglandin D synthase) in the cerebrospinal fluid (CSF) of patients with various neurological disorders was analyzed by capillary isoelectric focusing (CIEF)...
  55. Morse J, Pilkonis P, Houck P, Frank E, Reynolds C. Impact of cluster C personality disorders on outcomes of acute and maintenance treatment in late-life depression. Am J Geriatr Psychiatry. 2005;13:808-14 pubmed
    Personality disorders (PDs) have been associated with poor treatment outcomes in acute treatments for late-life depression and with persistent functional impairment after recovery from an episode of depression.
  56. Pueta M, Rovasio R, Abate P, Spear N, Molina J. Prenatal and postnatal ethanol experiences modulate consumption of the drug in rat pups, without impairment in the granular cell layer of the main olfactory bulb. Physiol Behav. 2011;102:63-75 pubmed publisher
    ..5g/kg ethanol i.g. each day and allowed to perform regular nursing activities. During postnatal days (PDs) 15 and 16, ethanol intake of pups was assessed along with aspects of their general activity...
  57. Inui T, Mase M, Shirota R, Nagashima M, Okada T, Urade Y. Lipocalin-type prostaglandin D synthase scavenges biliverdin in the cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2014;34:1558-67 pubmed publisher
    Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is the second major protein in human cerebrospinal fluid (CSF) and belongs to the lipocalin superfamily composed of various secretory lipophilic ligand transporter proteins...
  58. Kugathas S, Audouze K, Ermler S, Orton F, Rosivatz E, Scholze M, et al. Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX-2 Active Site, and Implications for Endocrine Disruption. Environ Health Perspect. 2016;124:452-9 pubmed publisher
    ..We assessed the ability of pesticides that are commonly used in the European Union to suppress prostaglandin D2 (PGD2) synthesis. Changes in PGD2 secretion in juvenile mouse Sertoli cells (SC5 cells) were measured using an ELISA...
  59. Gritti E, Samuel D, Lang M. Diagnostic Agreement Between Clinicians and Clients: The Convergent and Discriminant Validity of the SWAP-200 and MCMI-III Personality Disorder Scales. J Pers Disord. 2016;30:796-812 pubmed
    ..No studies have systematically documented the agreement between these sources for the entire array of DSM-5 PDs using comprehensive measures and experienced clinicians' judgments...
  60. Bascom E, Napolitano M. Breastfeeding Duration and Primary Reasons for Breastfeeding Cessation among Women with Postpartum Depressive Symptoms. J Hum Lact. 2016;32:282-91 pubmed publisher
    ..This study examined the breastfeeding behaviors of women with postpartum depressive symptoms (PDS) to identify potential motivations for early breastfeeding cessation...
  61. Khoorjestan S, Rouhi G, Toolabi K. An investigation of the effects of suture patterns on mechanical strength of intestinal anastomosis: an experimental study. Biomed Tech (Berl). 2017;62:429-437 pubmed publisher
    ..horizontal distance between stitches, and a 3, 5, and 7 mm distance from the edge of tissue with 3-0 Silk and 3-0 PDS sutures to maximize the strength of anastomosis (10 specimens in each group)...
  62. Carrasquilla G, Frumento P, Berglund A, Borgfeldt C, Bottai M, Chiavenna C, et al. Postmenopausal hormone therapy and risk of stroke: A pooled analysis of data from population-based cohort studies. PLoS Med. 2017;14:e1002445 pubmed publisher
    ..crude and multivariable-adjusted associations between HT and stroke risk by estimating percentile differences (PDs) with 95% confidence intervals (CIs)...
  63. Papanastasopoulos P, Repanti M, Damaskou V, Bravou V, Papadaki H. Investigating differentiation mechanisms of the constituent cells of sex cord-stromal tumours of the ovary. Virchows Arch. 2008;453:465-71 pubmed publisher
    ..Sertoli cells expressed anti-Mullerian hormone (AMH), SOX-9, prostaglandin D synthase (Pgds) and bcl-2 (in four of four cases); sonic hedgehog (Shh) and p53 (in three of four cases) and ..
  64. Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi B, et al. PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nat Commun. 2015;6:7514 pubmed publisher
    ..Systemic gene deficiency of haematopoietic PGD synthase (H-PGDS(-/-)) exacerbates all of the manifestations accompanying severe mast cell hyperplasia in the intestine...
  65. Yuan H, Li X, Yang W, Li F, Li Y. Inducible Nitric Oxide Synthase in the Duodenal Mucosa Is Associated with Mast Cell Degranulation in Patients with Functional Dyspepsia. Ann Clin Lab Sci. 2015;45:522-7 pubmed
    ..According to the Rome III consensus, FD can be subdivided into PDS (postprandial distress syndrome) and EPS (epigastric pain syndrome)...
  66. Radnai B, Sturm E, Stančić A, Jandl K, Labocha S, Ferreirós N, et al. Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease. J Crohns Colitis. 2016;10:1087-95 pubmed publisher
    ..In addition, we show that serum levels of PGD2 and Δ(12)-PGJ2 were increased in CD patients as compared with control individuals...
  67. Marsman E, de Rooij T, van Eijck C, Boerma D, Bonsing B, van Dam R, et al. Pancreatoduodenectomy with colon resection for cancer: A nationwide retrospective analysis. Surgery. 2016;160:145-152 pubmed publisher
    ..Survival was analyzed per histopathologic diagnosis. After screening 3,218 consecutive PDs, 50 (1.6%) PD-colon patients (median age 66 years [interquartile range 55-72], 33 [66%] men) were included...
  68. McHale C, Mohammed Z, Deppen J, Gomez G. Interleukin-6 potentiates Fc?RI-induced PGD2 biosynthesis and induces VEGF from human in situ-matured skin mast cells. Biochim Biophys Acta Gen Subj. 2018;1862:1069-1078 pubmed publisher
    ..Mechanistically, IL-6 enhanced Fc?RI-induced COX?2 expression, PGD2 biosynthesis, and VEGF production in a STAT3 dependent manner...
  69. Sui D, Wilson J. Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase. Arch Biochem Biophys. 2000;382:262-74 pubmed
    Insulin-like growth factor binding protein-4, Miz-1, leptin, prostaglandin D synthase, and granulin precursor were identified as proteins interacting with the N-terminal half of mammalian Type III hexokinase (HKIII) in the yeast two-..
  70. Suzuki A, Ji G, Numabe Y, Muramatsu M, Gomi K, Kanazashi M, et al. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. Biochem Biophys Res Commun. 2004;317:887-92 pubmed
    ..01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in ..
  71. Zhang Z, Wang X, Su H, Pan Y, Han J, Zhang T, et al. Effect of sulfated galactan from Porphyra haitanensis on H2O2-induced premature senescence in WI-38 cells. Int J Biol Macromol. 2018;106:1235-1239 pubmed publisher
    ..The proportion of SA-?-gal positive cells in porphyran group decreases from 53% to 23% in the cultures at 30 PDs. Porphyran has been detected specifically reducing SAHF-like foci formation in senescent cells...
  72. Saso L, Leone M, Sorrentino C, Giacomelli S, Silvestrini B, Grima J, et al. Quantification of prostaglandin D synthetase in cerebrospinal fluid: a potential marker for brain tumor. Biochem Mol Biol Int. 1998;46:643-56 pubmed
    ..5,3,99,2), a 30 kDa glycoprotein also known as beta-trace protein that catalyzes the formation of prostaglandin D2 (PGD2) from PGH2, was purified to apparent homogeneity from human cerebrospinal fluid (CSF) using a two-step procedure ..
  73. Kumar S, Palaia T, Hall C, Ragolia L. Role of Lipocalin-type prostaglandin D2 synthase (L-PGDS) and its metabolite, prostaglandin D2, in preterm birth. Prostaglandins Other Lipid Mediat. 2015;118-119:28-33 pubmed publisher
    ..the role of prostaglandin D2 during pregnancy and its mediator Lipocalin-type prostaglandin D2 synthase (L-PGDS) as a predictor of preterm birth (PTB)...
  74. Sorensen C, Johnson M, Norton B, Callaghan J, Van Dillen L. Asymmetry of lumbopelvic movement patterns during active hip abduction is a risk factor for low back pain development during standing. Hum Mov Sci. 2016;50:38-46 pubmed publisher
    ..test of active hip abduction in back-healthy people who developed LBP symptoms during standing (Pain Developers; PDs) compared to back-healthy people who did not develop LBP symptoms during standing (Non Pain Developers, NPDs)...
  75. Portioli C, Bovi M, Benati D, Donini M, Perduca M, Romeo A, et al. Novel functionalization strategies of polymeric nanoparticles as carriers for brain medications. J Biomed Mater Res A. 2017;105:847-858 pubmed publisher
    ..E modified peptide (pep-apoE) responsible for LDLR binding, or with lipocalin-type prostaglandin-d-synthase (L-PGDS), highly expressed in the brain...
  76. Li X, Cao F, Yu D, Chen J, Sun Z, Shen Y, et al. All Inorganic Halide Perovskites Nanosystem: Synthesis, Structural Features, Optical Properties and Optoelectronic Applications. Small. 2017;13: pubmed publisher
    ..in optoelectronic devices and optical applications, such as light-emitting diodes (LEDs), photodetectors (PDs), solar cells (SCs), and lasing, is presented...
  77. Singh S, Paul M, Parsons H, Burns T, Tyrer P, Fazel S, et al. A prospective, quantitative study of mental health act assessments in England following the 2007 amendments to the 1983 act: did the changes fulfill their promise?. BMC Psychiatry. 2017;17:246 pubmed publisher
    ..were intended to remove perceived obstacles to the detention of high risk patients with personality disorders (PDs), sexual deviance and learning disabilities (LDs)...
  78. Reddy C, Lee S, Yoon J, Kim J, Lee S, Hur M, et al. Molecular Cloning and Characterization of Carotenoid Pathway Genes and Carotenoid Content in Ixeris dentata var. albiflora. Molecules. 2017;22: pubmed publisher
    ..Phytoene synthase (PSY), phytoene desaturase (PDS) ξ-carotene desaturase (ZDS), lycopene β-cyclase (LCYB), lycopene ε-cyclase (LCYE), ε-ring carotene hydroxylase ..
  79. DePietro D, Kiefer R, Redmond J, Hoffmann J, Trerotola S, Nadolski G. The 2017 Integrated IR Residency Match: Results of a National Survey of Applicants and Program Directors. J Vasc Interv Radiol. 2018;29:114-124 pubmed publisher
    To characterize and compare the experiences of matched applicants and program directors (PDs) participating in the first large-scale integrated interventional radiology (IR) residency match...
  80. Pereira P, Assis P, Prado M, Ramos S, Aronoff D, de Paula Silva F, et al. Prostaglandins D2 and E2 have opposite effects on alveolar macrophages infected with Histoplasma capsulatum. J Lipid Res. 2018;59:195-206 pubmed publisher
    ..capsulatum infection, PGE2 has immunosuppressive effects, and the balance between these two PGs may limit collateral immune damage at the expense of microbial containment. ..
  81. Szucs A, Elson R, Rabinovich M, Abarbanel H, Selverston A. Nonlinear behavior of sinusoidally forced pyloric pacemaker neurons. J Neurophysiol. 2001;85:1623-38 pubmed
    ..was applied in three configurations of the pacemaker neurons: 1) the complete pacemaker group, 2) the two PDs without the AB, and 3) the AB neuron isolated from the PDs...
  82. Fujimori K, Maruyama T, Kamauchi S, Urade Y. Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated ?¹²-PGJ? acting through PPAR?-dependent and independent pathways. Gene. 2012;505:46-52 pubmed publisher
    Lipocalin-type prostaglandin (PG) D synthase (L-PGDS)-produced PGD(2) accelerates adipogenesis. In this study, we investigated the molecular mechanism of PGD(2)-mediated activation of adipogenesis in mouse adipocytic 3T3-L1 cells...
  83. Trabanelli S, Chevalier M, Martinez Usatorre A, Gomez Cadena A, Salomé B, Lecciso M, et al. Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis. Nat Commun. 2017;8:593 pubmed publisher
    ..ILC2s are increased and hyper-activated through the interaction of CRTH2 and NKp30 with elevated tumour-derived PGD2 and B7H6, respectively...
  84. Eaton N, Greene A. Personality disorders: community prevalence and socio-demographic correlates. Curr Opin Psychol. 2018;21:28-32 pubmed publisher
    Multiple studies have reported community prevalence rates of personality disorders (PDs), but these studies differed in terms of diagnostic criteria, assessment instruments, communities sampled, and size, producing widely ranging ..
  85. Nam A, Kim S, Jeong J, Song K, Koo T, Seo K. Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs. Pol J Vet Sci. 2017;20:611-613 pubmed publisher
    This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW)...
  86. Gilbert D, LaBare J, Keough K, Feist T. Child Neurology Residency Program Directors and Program Coordinators 2016 Workforce Survey. Pediatr Neurol. 2018;79:21-27 pubmed publisher
    Responsibilities of Program Directors' (PDs) and Program Coordinators' (PCs) roles continue to evolve within Graduate Medical Education (GME)...
  87. Kuruvilla A, Hochwald G, Ghiso J, Castano E, Pizzolato M, Frangione B. Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid. Brain Res. 1991;565:337-40 pubmed
    ..Amino terminal sequence analysis yields the sequence A P E A Q V S V Q P N F Q Q D K F L G with no homology to known proteins, indicating that beta-trace is a novel CSF protein. ..
  88. Zahn M, Mader M, Schmidt B, Bollensen E, Felgenhauer K. Purification and N-terminal sequence of beta-trace, a protein abundant in human cerebrospinal fluid. Neurosci Lett. 1993;154:93-5 pubmed
    ..Thus, 30 years after its discovery beta-trace might unravel as a well-known protein of the prostaglandin metabolism. ..
  89. Hokari R, Kurihara C, Nagata N, Aritake K, Okada Y, Watanabe C, et al. Increased expression of lipocalin-type-prostaglandin D synthase in ulcerative colitis and exacerbating role in murine colitis. Am J Physiol Gastrointest Liver Physiol. 2011;300:G401-8 pubmed publisher
    ..We investigated the expression of enzymes for PGD(2) synthesis, prostaglandin D synthase (PGDS), and its relation to the activity of colitis in UC patients...
  90. Lim S, Chen D, Teo H, Roos A, Jansson A, Nyman T, et al. Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase. J Lipid Res. 2013;54:1630-43 pubmed publisher
    Lipocalin prostaglandin D synthase (L-PGDS) regulates synthesis of an important inflammatory and signaling mediator, prostaglandin D2 (PGD2)...
  91. Gupta R, Yadav A, Misra R, Aggarwal A. Urinary prostaglandin D synthase as biomarker in lupus nephritis: a longitudinal study. Clin Exp Rheumatol. 2015;33:694-8 pubmed
    Urinary prostaglandin D synthase (uPGDS) has been identified as a biomarker in lupus nephritis (LN) mice model as well as in humans...
  92. Cil O, Haggie P, Phuan P, Tan J, Verkman A. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016;27:3706-3714 pubmed
    ..In vitro, a pyrazole-thiophenesulfonamide, PDSinh-C01, inhibited Cl-/anion exchange mediated by mouse pendrin with a 50% inhibitory ..