PTEN

Summary

Gene Symbol: PTEN
Description: phosphatase and tensin homolog
Alias: 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, mitochondrial PTENalpha, mitochondrial phosphatase and tensin protein alpha, mutated in multiple advanced cancers 1, phosphatase and tensin-like protein, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, protein tyrosine phosphatase
Species: human
Products:     PTEN

Top Publications

  1. Sakamoto K, Iwasaki K, Sugiyama H, Tsuji Y. Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications. Mol Biol Cell. 2009;20:1606-17 pubmed publisher
    ..regulation of PI3-kinase (PI3K) and the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) plays a pivotal role in various cell functions...
  2. Zhang L, Ho Fun Lee V, Wong A, Kwong D, Zhu Y, Dong S, et al. MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis. 2013;34:454-63 pubmed publisher
    ..we found that miR-144 was inversely correlated with the tumor suppressor gene phosphatase and tensin homolog (PTEN) in NPC specimens and cell lines, and then we identified PTEN as a direct target of miR-144 in NPC cell lines...
  3. Yin Y, Shen W. PTEN: a new guardian of the genome. Oncogene. 2008;27:5443-53 pubmed publisher
    The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor is a phosphatase that antagonizes the phosphoinositol-3-kinase/AKT signaling pathway and suppresses cell survival as well as cell proliferation...
  4. Liu B, Wu X, Liu B, Wang C, Liu Y, Zhou Q, et al. MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN. Biochim Biophys Acta. 2012;1822:1692-704 pubmed publisher
    ..Phosphatase and tensin homolog (PTEN) was a direct target of miR-26a...
  5. Bian Y, Hall B, Sun Z, Molinolo A, Chen W, Gutkind J, et al. Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene. 2012;31:3322-32 pubmed publisher
    ..Conditional activation of the PI3K/Akt pathway due to Pten deletion in the mouse head and neck epithelia gives rise to hyperproliferation, but only a few lesions progress to ..
  6. Zou Z, Zhang R, Fan L, Wang L, Fang C, Zhang L, et al. Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. Leuk Lymphoma. 2013;54:1159-64 pubmed publisher
    Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is one of the best-studied tumor suppressor genes which can promote cell proliferation and contribute to tumorigenesis...
  7. Palumbo T, Faucz F, Azevedo M, Xekouki P, Iliopoulos D, Stratakis C. Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway. Oncogene. 2013;32:1651-9 pubmed publisher
    ..that miR-26b and miR-128 affected pituitary tumor cell behavior through regulation of their direct targets, PTEN and BMI1, respectively...
  8. Huang F, Zhang L, Wu D, Yuan X, Yu Y, Zhao X, et al. PTEN regulates BCRP/ABCG2 and the side population through the PI3K/Akt pathway in chronic myeloid leukemia. PLoS ONE. 2014;9:e88298 pubmed publisher
    ..enhanced drug resistance along with downregulated phosphatase and tensin homologue deleted on chromosome -10 (PTEN) and activated phosphorylated-Akt (p-Akt)...
  9. Won H, Jung C, Chun S, Kang J, Kim Y, Sun D, et al. Difference in expression of EGFR, pAkt, and PTEN between oropharyngeal and oral cavity squamous cell carcinoma. Oral Oncol. 2012;48:985-990 pubmed publisher
    The aims of this study were to evaluate the expression of EGFR, PI3K, Akt, mTOR, and PTEN in the oral cavity and oropharyngeal cancers, and to investigate their clinical significance as prognostic markers...

More Information

Publications443 found, 100 shown here

  1. Huang F, Wu D, Zhang L, Yu Y, Yuan X, Li W, et al. Inactivation of PTEN increases ABCG2 expression and the side population through the PI3K/Akt pathway in adult acute leukemia. Cancer Lett. 2013;336:96-105 pubmed publisher
    ..that ABCG2 expression and SP cell ratios can be upregulated by the inactivation of phosphatase and tensin homolog (PTEN) protein, achieved in this study by removing inhibition of the PI3K/Akt pathway...
  2. Qu C, Liang Z, Huang J, Zhao R, Su C, Wang S, et al. MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell Cycle. 2012;11:785-96 pubmed publisher
    ..A target prediction algorithm suggests that miR‑205 regulates expression of PTEN, a tumor-suppressor...
  3. Maccario H, Perera N, Gray A, Downes C, Leslie N. Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J Biol Chem. 2010;285:12620-8 pubmed publisher
    The PTEN (phosphatase and tensin homolog) tumor suppressor is a phosphatase that inhibits phosphoinositide 3-kinase-dependent signaling by metabolizing the phosphoinositide lipid phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)) at ..
  4. Moult P, Cross A, Santos S, Carvalho A, Lindsay Y, Connolly C, et al. Leptin regulates AMPA receptor trafficking via PTEN inhibition. J Neurosci. 2010;30:4088-101 pubmed publisher
    ..In addition, leptin enhanced phosphorylation of the lipid phosphatase PTEN which inhibits PTEN function and elevates PtdIns(3,4,5)P(3) levels...
  5. Lacey J, Yang H, Gaudet M, Dunning A, Lissowska J, Sherman M, et al. Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study. Gynecol Oncol. 2011;120:167-73 pubmed publisher
    We assessed whether common genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2-genes that reportedly are frequently altered in endometrial cancer-was associated with risk of endometrial cancer...
  6. Kavela S, Shinde S, Ratheesh R, Viswakalyan K, Bashyam M, Gowrishankar S, et al. PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res. 2013;73:205-14 pubmed publisher
    b>PTEN is a well-defined tumor suppressor gene that antagonizes the PI3K/Akt pathway to regulate a multitude of cellular processes, such as survival, growth, motility, invasiveness, and angiogenesis...
  7. Shen W, Balajee A, Wang J, Wu H, Eng C, Pandolfi P, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 2007;128:157-70 pubmed
    A broad spectrum of mutations in PTEN, encoding a lipid phosphatase that inactivates the P13-K/AKT pathway, is found associated with primary tumors...
  8. Li H, Gao Q, Guo L, Lu S. The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells. Cancer Biol Ther. 2011;11:950-8 pubmed
    ..Furthermore, PTEN, rather than mTOR, was found to be involved in SP cell regulation in primary ESCC cells...
  9. Redfern R, Daou M, Li L, Munson M, Gericke A, Ross A. A mutant form of PTEN linked to autism. Protein Sci. 2010;19:1948-56 pubmed publisher
    The tumor suppressor, phosphatase, and tensin homologue deleted on chromosome 10 (PTEN), is a phosphoinositide (PI) phosphatase specific for the 3-position of the inositol ring...
  10. Pal A, Barber T, van de Bunt M, Rudge S, Zhang Q, Lachlan K, et al. PTEN mutations as a cause of constitutive insulin sensitivity and obesity. N Engl J Med. 2012;367:1002-11 pubmed publisher
    ..The tumor-suppressor phosphatase and tensin homologue (PTEN) has roles in both cellular growth and metabolic signaling...
  11. Freeman D, Li A, Wei G, Li H, Kertesz N, Lesche R, et al. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003;3:117-30 pubmed
    We show in this study that PTEN regulates p53 protein levels and transcriptional activity through both phosphatase-dependent and -independent mechanisms...
  12. Farooq A, Walker L, Bowling J, Audisio R. Cowden syndrome. Cancer Treat Rev. 2010;36:577-83 pubmed publisher
    ..It is inherited in an autosomal dominant manner with ?80% of patients having a germ-line mutation of the PTEN tumour suppressor gene. Presenting signs and symptoms are highly non-specific...
  13. Kim J, Chae Y, Sohn S, Kang B, Moon J, Lee S, et al. Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer. Oncology. 2010;79:278-82 pubmed publisher
    Signaling through the PI3K/PTEN/AKT/mTOR pathway is responsible for balancing cell survival and apoptosis...
  14. Wang X, Trotman L, Koppie T, Alimonti A, Chen Z, Gao Z, et al. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 2007;128:129-39 pubmed
    The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis...
  15. Kang Y, Lee H, Kim W. Promoter methylation and silencing of PTEN in gastric carcinoma. Lab Invest. 2002;82:285-91 pubmed
    The PTEN/MMAC1/TEP1 gene (phosphatase and tensin homolog deleted on chromosome 10/mutated in multiple advanced cancers/TGF-beta regulated and epithelial cell enriched phosphatase 1), which regulates the signaling pathways of Akt, is a ..
  16. Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
    ..We focused on human seminoma using the TCAM2 cell line. Through ER?, 10 nM estradiol (E2) was able to induce PTEN gene expression and promoter transactivation...
  17. Lou Y, Yang X, Wang F, Cui Z, Huang Y. MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein. Int J Mol Med. 2010;26:819-27 pubmed
    ..Furthermore, we demonstrated that knockdown of miR-21 significantly increased the expression of PTEN, a known tumor suppressor in ovarian cancer...
  18. Xiong B, Cheng Y, Ma L, Zhang C. MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells. Int J Oncol. 2013;42:219-28 pubmed publisher
    ..colorectal cancer (CRC) and to elucidate the regulation of phosphatase and tensin homologue (PTEN) gene by miR-21. MiR-21 expression was investigated in 30 CRC samples and five CRC cell lines...
  19. Razis E, Briasoulis E, Vrettou E, Skarlos D, Papamichael D, Kostopoulos I, et al. Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study. BMC Cancer. 2008;8:234 pubmed publisher
    ..study was to explore EGFR and the downstream effector phosphatase and tensin homologue deleted on chromosome 10 (PTEN) as potential predictors of response to cetuximab...
  20. Hopkins B, Fine B, Steinbach N, Dendy M, Rapp Z, Shaw J, et al. A secreted PTEN phosphatase that enters cells to alter signaling and survival. Science. 2013;341:399-402 pubmed publisher
    Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppressor and an antagonist of the phosphoinositide-3 kinase (PI3K) pathway...
  21. Van Themsche C, Leblanc V, Parent S, Asselin E. X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. J Biol Chem. 2009;284:20462-6 pubmed publisher
    ..However, the underlying mechanisms are poorly understood. We have observed that XIAP associates with PTEN (phosphatase and tensin homolog deleted on chromosome ten), the best characterized negative regulator of Akt ..
  22. Vazquez F, Ramaswamy S, Nakamura N, Sellers W. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000;20:5010-8 pubmed
    The PTEN gene is a tumor suppressor localized in the frequently altered chromosomal region 10q23...
  23. Cesaratto L, Calligaris S, Vascotto C, Deganuto M, Bellarosa C, Quadrifoglio F, et al. Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway. J Mol Med (Berl). 2007;85:1099-112 pubmed
    ..of APE1/Ref-1 was followed by a concomitant activation of Egr-1 transcription factor and by an upregulation of PTEN tumor suppressor, an Egr-1 target gene, leading to inhibition of cell growth...
  24. Lee J, Yang H, Georgescu M, Di Cristofano A, Maehama T, Shi Y, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. 1999;99:323-34 pubmed
    The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a phosphatase that can act on both polypeptide and phosphoinositide substrates in vitro...
  25. Xing F, Persaud Y, Pratilas C, Taylor B, Janakiraman M, She Q, et al. Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF. Oncogene. 2012;31:446-57 pubmed publisher
    ..We identified concurrent mutational inactivation of the PTEN and RB1 tumor suppressors as a mechanism for loss of BRAF/MEK dependence in melanomas harboring (V600E)BRAF ..
  26. Zhou X, Waite K, Pilarski R, Hampel H, Fernandez M, Bos C, et al. Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway. Am J Hum Genet. 2003;73:404-11 pubmed
    Germline intragenic mutations in PTEN are associated with 80% of patients with Cowden syndrome (CS) and 60% of patients with Bannayan-Riley-Ruvalcaba syndrome (BRRS)...
  27. Carver B, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell. 2011;19:575-86 pubmed publisher
    ..We find that AR transcriptional output is decreased in human and murine tumors with PTEN deletion and that PI3K pathway inhibition activates AR signaling by relieving feedback inhibition of HER kinases...
  28. Day F, Jorissen R, Lipton L, Mouradov D, Sakthianandeswaren A, Christie M, et al. PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer. Clin Cancer Res. 2013;19:3285-96 pubmed publisher
    PIK3CA and PTEN mutations are prevalent in colorectal cancer and potential markers of response to mitogen-activated protein/extracellular signal-regulated kinase inhibitors and anti-EGF receptor antibody therapy...
  29. Kawaguchi K, Oda Y, Saito T, Takahira T, Yamamoto H, Tamiya S, et al. Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas. Hum Pathol. 2005;36:357-63 pubmed
    The PTEN/MMAC1 ( PTEN ) gene was identified as a tumor suppressor gene encoding a cytoplasmic protein that controls cellular processes...
  30. Planchon S, Waite K, Eng C. The nuclear affairs of PTEN. J Cell Sci. 2008;121:249-53 pubmed publisher
    b>PTEN encodes a major tumor-suppressor protein that is a dual-specificity phosphatase. Inactivation of PTEN has been shown to be involved in heritable and sporadic cancers...
  31. Kim S, Domon Dell C, Kang J, Chung D, Freund J, Evers B. Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. J Biol Chem. 2004;279:4285-91 pubmed
    The PTEN (phosphatase and tensin homolog deleted on chromosome ten) tumor suppressor gene affects multiple cellular processes including cell growth, proliferation, and cell migration by antagonizing phosphatidylinositol 3-kinase (PI3K)...
  32. Waite K, Eng C. Protean PTEN: form and function. Am J Hum Genet. 2002;70:829-44 pubmed
    Germline mutations distributed across the PTEN tumor-suppressor gene have been found to result in a wide spectrum of phenotypic features...
  33. Maccario H, Perera N, Davidson L, Downes C, Leslie N. PTEN is destabilized by phosphorylation on Thr366. Biochem J. 2007;405:439-44 pubmed
    Although PTEN (phosphatase and tensin homologue deleted on chromosome 10) is one of the most commonly mutated tumour suppressors in human cancers, loss of PTEN expression in the absence of mutation appears to occur in an even greater ..
  34. Myers M, Stolarov J, Eng C, Li J, Wang S, Wigler M, et al. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A. 1997;94:9052-7 pubmed
  35. Song C, Park S, Eom K, Kim J, Kim S, Kim J, et al. Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers. Breast Cancer Res. 2010;12:R20 pubmed publisher
    ..Immunohistochemical analyses of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), PI3K-p110alpha, phospho-AKT, phospho-p70S6 kinase, phospho-S6 ribosomal protein, phospho-RAF, phospho-p44/42 MAPK,..
  36. Orloff M, Eng C. Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome. Oncogene. 2008;27:5387-97 pubmed publisher
    Germline PTEN (Phosphatase and TENsin homologue deleted on chromosome TEN) mutations predispose to phenotypically diverse disorders that share several overlapping clinical features: Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, ..
  37. Gil A, Andrés Pons A, Fernandez E, Valiente M, Torres J, Cervera J, et al. Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol Biol Cell. 2006;17:4002-13 pubmed
    The targeting of the tumor suppressor PTEN protein to distinct subcellular compartments is a major regulatory mechanism of PTEN function, by controlling its access to substrates and effector proteins...
  38. Lehman J, Waning D, Batuello C, Cipriano R, Kadakia M, Mayo L. Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress. J Biol Chem. 2011;286:36631-40 pubmed publisher
    ..The phosphatase and tensin homolog (PTEN) can function as a dual specificity lipid/protein phosphatase...
  39. Smith J, Tachibana I, Passe S, Huntley B, Borell T, Iturria N, et al. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J Natl Cancer Inst. 2001;93:1246-56 pubmed
    ..Alterations of the EGFR, PTEN, and p53 genes and of chromosomes 7 and 10 were examined by fluorescence in situ hybridization, semiquantitative ..
  40. Ozturk O, Canbay E, Kahraman O, Fatih Seyhan M, Aydogan F, Celik V, et al. HER2 Ile655Val and PTEN IVS4 polymorphisms in patients with breast cancer. Mol Biol Rep. 2013;40:1813-8 pubmed publisher
    Although HER2/PTEN pathway is commonly disrupted in cancer, association of HER2 and PTEN polymorphisms with breast cancer (BC) remains controversial...
  41. Lynch E, Ostermeyer E, Lee M, Arena J, Ji H, Dann J, et al. Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis. Am J Hum Genet. 1997;61:1254-60 pubmed
    PTEN, a protein tyrosine phosphatase with homology to tensin, is a tumor-suppressor gene on chromosome 10q23. Somatic mutations in PTEN occur in multiple tumors, most markedly glioblastomas...
  42. Furnari F, Lin H, Huang H, Cavenee W. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci U S A. 1997;94:12479-84 pubmed
    ..The PTEN gene (also called MMAC1 and TEP1) maps to chromosome region 10q23 and has been implicated as a target of alteration in gliomas and also in ..
  43. Ghosh Choudhury T, Mandal C, Woodruff K, St Clair P, Fernandes G, Choudhury G, et al. Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth. Breast Cancer Res Treat. 2009;118:213-28 pubmed publisher
    ..model in nude mice, we for the first time report that the fish oil diet significantly increased the level of PTEN protein in the breast tumors...
  44. Li H, Yang B. Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2. Oncotarget. 2012;3:1653-68 pubmed
    ..We found that these phenotypes were the results of miR-17 targeting PTEN. As a consequence, HIF1? and VEGF were up-regulated...
  45. Nelen M, Kremer H, Konings I, Schoute F, van Essen A, Koch R, et al. Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations. Eur J Hum Genet. 1999;7:267-73 pubmed
    ..CD was localised to chromosome 10q23 and the PTEN gene (also known as MMAC1 or TEP1) was shown to be involved. Germline mutations were identified in both familial and sporadic CD patients...
  46. Byron S, Gartside M, Wellens C, Mallon M, Keenan J, Powell M, et al. Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation. Cancer Res. 2008;68:6902-7 pubmed publisher
    KRAS activation and PTEN inactivation are frequent events in endometrial tumorigenesis, occurring in 10% to 30% and 26% to 80% of endometrial cancers, respectively...
  47. Huse J, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard S, et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev. 2009;23:1327-37 pubmed publisher
    ..over the last two decades has revealed the particular importance of the Akt pathway, and its molecular antagonist PTEN (phosphatase and tensin homolog), in the process of gliomagenesis...
  48. Sood A, McClain D, Maitra R, Basu Mallick A, Seetharam R, Kaubisch A, et al. PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer. Clin Colorectal Cancer. 2012;11:143-50 pubmed publisher
    ..tissue was tested by pyrosequencing for mutations at known hot spots in the KRAS, BRAF, PIK3CA, PIK3R1, AKT1, and PTEN genes...
  49. Butler M, Wang S, Chaganti R, Parsons R, Dalla Favera R. Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas. Genes Chromosomes Cancer. 1999;24:322-7 pubmed
    The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma, endometrial and prostate carcinomas. The PTEN gene product is a dual-specificity phosphatase with putative tumor suppressor function...
  50. Puzio Kuter A, Castillo Martin M, Kinkade C, Wang X, Shen T, Matos T, et al. Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 2009;23:675-80 pubmed publisher
    ..We show that combined deletion of p53 and Pten in bladder epithelium leads to invasive cancer in a novel mouse model...
  51. Leslie N, Bennett D, Lindsay Y, Stewart H, Gray A, Downes C. Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J. 2003;22:5501-10 pubmed
    The tumour suppressor PTEN is a PtdIns(3,4,5)P(3) phosphatase that regulates many cellular processes through direct antagonism of PI 3-kinase signalling...
  52. Lin P, Fosmire S, Park S, Park J, Baksh S, Modiano J, et al. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance. Mol Cancer. 2007;6:16 pubmed
    The PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) tumor suppressor gene is frequently mutated or deleted in a wide variety of solid tumors, and these cancers are generally more aggressive and difficult to treat than ..
  53. Yang J, Ren Y, Wang L, Li B, Chen Y, Zhao W, et al. PTEN mutation spectrum in breast cancers and breast hyperplasia. J Cancer Res Clin Oncol. 2010;136:1303-11 pubmed publisher
    Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is one of the most frequently mutated human tumor suppressor genes...
  54. Zhou J, Parada L. PTEN signaling in autism spectrum disorders. Curr Opin Neurobiol. 2012;22:873-9 pubmed publisher
    b>PTEN germline mutations are found in a small subset of children diagnosed with autism spectrum disorder (ASD) and accompanying macrocephaly...
  55. Chappell W, Green T, Spengeman J, McCubrey J, Akula S, Bertrand F. Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1. Cell Cycle. 2005;4:1389-95 pubmed
    ..Subsequent examination of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) revealed that total and phosphorylated PTEN protein was elevated in cells expressing constitutively active Notch-1...
  56. Wu S, Wang B, Yang Y, Feng X, Zhao X, Yang D. Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues. World J Gastroenterol. 2007;13:4554-9 pubmed
    To investigate the expressions of PTEN, PPM1A and P-Smad2 in hepatocellular carcinoma (HCC) and their significance...
  57. Antonarakis E, Keizman D, Zhang Z, Gurel B, Lotan T, Hicks J, et al. An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy. Cancer. 2012;118:6063-71 pubmed publisher
    Loss of the tumor suppressor PTEN is common in prostate cancer and may have prognostic significance...
  58. Park Y, Jung H, Choi M, Chang W, Choi Y, Do I, et al. Role of HER3 expression and PTEN loss in patients with HER2-overexpressing metastatic breast cancer (MBC) who received taxane plus trastuzumab treatment. Br J Cancer. 2014;110:384-91 pubmed publisher
    The aim of this study was to investigate the role of human epidermal growth factor receptor (HER3) and PTEN expression in patients with HER2-overexpressing metastatic breast cancer (MBC)...
  59. Konopka B, Paszko Z, Janiec Jankowska A, Goluda M. Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias. Cancer Lett. 2002;178:43-51 pubmed
    The quality and frequency of mutations in PTEN gene were assessed in 59 carcinomas and 6 hyperplasias of the endometrium in women. Screening for mutations was done in all exons of PTEN gene by the PCR-SSCP analysis and DNA sequencing...
  60. Li X, Zheng H, Takahashi H, Masuda S, Yang X, Takano Y. PTEN expression and mutation in colorectal carcinomas. Oncol Rep. 2009;22:757-64 pubmed
    The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor is a phosphatase that antagonizes the phosphoinositol-3-kinase/AKT signaling pathway and suppresses cell survival as well as cell proliferation...
  61. Bouali S, Chretien A, Ramacci C, Rouyer M, Becuwe P, Merlin J. PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-type, hormone refractory prostate cancer cells. Oncol Rep. 2009;21:731-5 pubmed
    Overexpression of epidermal growth factor receptor (EGFR) and mutation of pten tumor suppressor gene in human cancer cells leads to activated EGFR downstream signaling including PI3-kinase/AKT (PI3K/AKT) and/or mitogen-activated protein ..
  62. Xu J, Zhou J, Wei W, Wu G. Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. PLoS ONE. 2010;5:e10226 pubmed publisher
    ..Since Akt is negatively regulated by the tumor suppressor PTEN, we examined the TRAIL sensitivity in PTEN knockdown mouse prostate epithelial cells and found that PTEN(-/-) cells ..
  63. Maxwell G, Risinger J, Gumbs C, Shaw H, Bentley R, Barrett J, et al. Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. Cancer Res. 1998;58:2500-3 pubmed
    Mutation and deletion of the PTEN tumor suppressor gene occurs in about 40% of endometrial carcinomas...
  64. Modur V, Nagarajan R, Evers B, Milbrandt J. FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J Biol Chem. 2002;277:47928-37 pubmed
    Mutations in PTEN occur in 60-80% of prostate cancers and lead to a constitutive activation of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO family of forkhead transcription factors FKHRL1 and FKHR...
  65. Sarver A, Li L, Subramanian S. MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration. Cancer Res. 2010;70:9570-80 pubmed publisher
    ..sarcoma, RMS, and colon cancer cell lines revealed deregulation of a miRNA network composed of miR-183-EGR1-PTEN in these tumors...
  66. Lobo G, Waite K, Planchon S, Romigh T, Nassif N, Eng C. Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function. Hum Mol Genet. 2009;18:2851-62 pubmed publisher
    Germline and somatic PTEN mutations are found in Cowden syndrome (CS) and multiple sporadic malignancies, respectively. PTEN function appears to be modulated by subcellular compartmentalization, and mislocalization may affect function...
  67. Laurent Puig P, Cayre A, Manceau G, Buc E, Bachet J, Lecomte T, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol. 2009;27:5924-30 pubmed publisher
    ..was assessed by chromogenic in situ hybridization and fluorescent in situ hybridization, and the expression of PTEN was assessed by immunochemistry...
  68. Weng L, Smith W, Dahia P, Ziebold U, Gil E, Lees J, et al. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Res. 1999;59:5808-14 pubmed
    PTEN/MMAC1/TEP1, a tumor suppressor gene, is frequently mutated in a variety of human cancers...
  69. Silva A, Yunes J, Cardoso B, Martins L, Jotta P, Abecasis M, et al. PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest. 2008;118:3762-74 pubmed publisher
    Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein deletion and subsequent activation of the PI3K/Akt signaling pathway are common in cancer...
  70. Cetin Z, Ozbilim G, Erdogan A, Luleci G, Karauzum S. Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR. Med Oncol. 2010;27:853-60 pubmed publisher
    ..Surgically resected samples were obtained from 50 patients with non-small-cell-lung cancer. PTEN, Mcl-1 and EGFR protein expression levels were evaluated by Western-blot...
  71. Byun D, Cho K, Ryu B, Lee M, Park J, Chae K, et al. Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma. Int J Cancer. 2003;104:318-27 pubmed
    Mutational alterations of PTEN and PIK3CA, which negatively and positively regulate PI3-kinase activity, respectively, have been observed in many types of human cancer...
  72. Okumura K, Mendoza M, Bachoo R, Depinho R, Cavenee W, Furnari F. PCAF modulates PTEN activity. J Biol Chem. 2006;281:26562-8 pubmed
    The PTEN protein has a single catalytic domain possessing both lipid phosphoinositol and protein phosphatase activities...
  73. Vitolo M, Weiss M, Szmacinski M, Tahir K, Waldman T, Park B, et al. Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. Cancer Res. 2009;69:8275-83 pubmed publisher
    ..loss-of-function mutations in the catalytic domain of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) or have reduced PTEN expression through loss of heterozygosity and/or epigenetic silencing mechanisms...
  74. Slattery M, Herrick J, Lundgreen A, Fitzpatrick F, Curtin K, Wolff R. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Carcinogenesis. 2010;31:1604-11 pubmed publisher
    Serine/threonine protein kinase 11 (STK11) and phosphatase tensin homolog deleted on chromosome 10 (PTEN) link insulin sensitivity and metabolic signaling to inflammation and other hormonal factors and colorectal cancer...
  75. Pezzolesi M, Platzer P, Waite K, Eng C. Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome. Am J Hum Genet. 2008;82:1141-9 pubmed publisher
    Germline mutations in the gene encoding phosphatase and tensin homolog deleted on chromosome ten (PTEN [MIM 601728]) are associated with a number of clinically distinct heritable cancer syndromes, including both Cowden syndrome (CS) and ..
  76. Whelan J, Kellogg A, Shewchuk B, Hewan Lowe K, Bertrand F. Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression. J Cell Biochem. 2009;107:992-1001 pubmed publisher
    Prostate tumorigenesis is associated with loss of PTEN gene expression. We and others have recently reported that PTEN is regulated by Notch-1 signaling...
  77. He X, Ni Y, Wang Y, Romigh T, Eng C. Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53. Hum Mol Genet. 2011;20:80-9 pubmed publisher
    Somatic and germline mutations in PTEN (phosphatase and tensin homolog deleted on chromosome 10) are found in sporadic cancers and Cowden syndrome patients, respectively...
  78. Fornari F, Milazzo M, Chieco P, Negrini M, Marasco E, Capranico G, et al. In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2. J Pathol. 2012;227:275-85 pubmed publisher
    ..These functions are, at least in part, exerted through the direct targeting of CDKN1A/p21, PTEN, AKT3 and TIMP2...
  79. Zheng H, Sun J, Li X, Yang X, Zhang Y, Xin Y. Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma. Pathol Int. 2003;53:659-66 pubmed
    To investigate the role of PTEN and matrix metalloproteinase-7 (MMP-7) expression in tumorigenesis and progression of gastric carcinoma, their expression in 113 gastric carcinomas was studied by immunohistochemistry...
  80. Wang M, Lu K, Zhu S, Dia E, Vivanco I, Shackleford G, et al. Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Res. 2006;66:7864-9 pubmed
    ..We have recently shown that coexpression of EGFRvIII and PTEN protein by glioblastoma cells is strongly associated with clinical response to EGFR kinase inhibitor therapy...
  81. Kurasawa Y, Shiiba M, Nakamura M, Fushimi K, Ishigami T, Bukawa H, et al. PTEN expression and methylation status in oral squamous cell carcinoma. Oncol Rep. 2008;19:1429-34 pubmed
    b>PTEN is a tumor suppressor gene located on chromosome10q23.3. In addition to genetic mutations and deletions, the down-regulation of PTEN has been found in various malignant tumors...
  82. He L, Ingram A, Rybak A, Tang D. Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J Clin Invest. 2010;120:2094-108 pubmed publisher
    Inactivation of phosphatase and tensin homolog (PTEN) is a critical step during tumorigenesis, and PTEN inactivation by genetic and epigenetic means has been well studied...
  83. Liu Z, Wang H, Liu J, Wang Z. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol Cell Biochem. 2013;372:35-45 pubmed publisher
    ..Meanwhile, miR-21 mimics could inhibit expression of PTEN mRNA and protein and the luciferase activity of a PTEN 3'-untranslated region (UTR)-based reporter construct in ..
  84. Busa T, Chabrol B, Perret O, Longy M, Philip N. Novel PTEN germline mutation in a family with mild phenotype: difficulties in genetic counseling. Gene. 2013;512:194-7 pubmed publisher
    b>PTEN gene (phosphatase and tensin homolog deleted on chromosome ten, MIM 601628) is a tumor suppressor gene implicated in PTEN hamartoma tumor syndromes (PHTS) including Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome and Proteus-like ..