Gene Symbol: PTBP1
Description: polypyrimidine tract binding protein 1
Alias: HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB, polypyrimidine tract-binding protein 1, 57 kDa RNA-binding protein PPTB-1, RNA-binding protein, heterogeneous nuclear ribonucleoprotein I, heterogeneous nuclear ribonucleoprotein polypeptide I, hnRNP I, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
Species: human
Products:     PTBP1

Top Publications

  1. Cobbold L, Wilson L, Sawicka K, King H, Kondrashov A, Spriggs K, et al. Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1. Oncogene. 2010;29:2884-91 pubmed publisher
    ..c-myc IRES trans-acting factors, Y-box binding protein 1 (YB-1) and polypyrimidine tract-binding protein 1 (PTB-1), bind more strongly (approximately 3...
  2. Hahm B, Cho O, Kim J, Kim Y, Kim J, Oh Y, et al. Polypyrimidine tract-binding protein interacts with HnRNP L. FEBS Lett. 1998;425:401-6 pubmed
    Polypyrimidine tract-binding protein (PTB) is involved in pre-mRNA splicing and internal ribosomal entry site (IRES)-dependent translation...
  3. Knoch K, Bergert H, Borgonovo B, Saeger H, Altkr ger A, Verkade P, et al. Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. Nat Cell Biol. 2004;6:207-14 pubmed
    ..that beta-cell stimulation induces the nucleocytoplasmic translocation of polypyrimidine tract-binding protein (PTB)...
  4. Pickering B, Mitchell S, Spriggs K, Stoneley M, Willis A. Bag-1 internal ribosome entry segment activity is promoted by structural changes mediated by poly(rC) binding protein 1 and recruitment of polypyrimidine tract binding protein 1. Mol Cell Biol. 2004;24:5595-605 pubmed
    ..internal ribosome entry segment (IRES) directs the synthesis of the p36 isoform of Bag-1 and that polypyrimidine tract binding protein 1 (PTB-1) and poly(rC) binding protein 1 (PCBP1) stimulate IRES-mediated translation initiation in ..
  5. Petoukhov M, Monie T, Allain F, Matthews S, Curry S, Svergun D. Conformation of polypyrimidine tract binding protein in solution. Structure. 2006;14:1021-7 pubmed
    The polypyrimidine tract binding protein (PTB) is an RNA binding protein that normally functions as a regulator of alternative splicing but can also be recruited to stimulate translation initiation by certain picornaviruses...
  6. Ghetti A, Pinol Roma S, Michael W, Morandi C, Dreyfuss G. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res. 1992;20:3671-8 pubmed
    ..b>hnRNP I, a basic protein of ca. 58,000 daltons by SDS-PAGE, is one of the abundant hnRNA-binding proteins...
  7. Gil A, Sharp P, Jamison S, Garcia Blanco M. Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Genes Dev. 1991;5:1224-36 pubmed
    The polypyrimidine tract of mammalian introns is recognized by a 62-kD protein (pPTB)...
  8. Patton J, Porro E, Galceran J, Tempst P, Nadal Ginard B. Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev. 1993;7:393-406 pubmed
    Previously, we characterized cDNAs encoding polypyrimidine tract-binding protein (PTB) and showed that a complex between PTB and a 100-kD protein was necessary for pre-mRNA splicing...
  9. Conte M, Grune T, Ghuman J, Kelly G, Ladas A, Matthews S, et al. Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold. EMBO J. 2000;19:3132-41 pubmed
    Polypyrimidine tract binding protein (PTB), an RNA binding protein containing four RNA recognition motifs (RRMs), is involved in both pre-mRNA splicing and translation initiation directed by picornaviral internal ribosome entry sites...

More Information

Publications116 found, 100 shown here

  1. Markovtsov V, Nikolic J, Goldman J, Turck C, Chou M, Black D. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol. 2000;20:7463-79 pubmed
    ..Heterogeneous nuclear ribonucleoprotein (hnRNP) H, polypyrimidine tract binding protein (PTB), and KH-type splicing-regulatory protein (KSRP) each bind to distinct elements within this sequence...
  2. De Nova Ocampo M, Villegas Sepúlveda N, Del Angel R. Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA. Virology. 2002;295:337-47 pubmed
    ..Although different antibodies against PTB were unable to react with any of the cellular proteins from C6/36, the recombinant His-PTB protein did bind to the ..
  3. Hamilton B, Genin A, Cron R, Rigby W. Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression. Mol Cell Biol. 2003;23:510-25 pubmed
    ..proteins that bind the CD154 3' untranslated region (3'UTR) as members of the polypyrimidine tract binding protein (PTB) family. One of these proteins is a previously unreported alternatively spliced PTB isoform, which we call PTB-T...
  4. Xie J, Lee J, Kress T, Mowry K, Black D. Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein. Proc Natl Acad Sci U S A. 2003;100:8776-81 pubmed
    ..The polypyrimidine-tract binding protein (PTB, or hnRNP I) is an important regulator of alternative pre-mRNA splicing, of viral RNA translation, and of mRNA localization...
  5. Oberstrass F, Auweter S, Erat M, Hargous Y, Henning A, Wenter P, et al. Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science. 2005;309:2054-7 pubmed
    The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons...
  6. Bushell M, Stoneley M, Kong Y, Hamilton T, Spriggs K, Dobbyn H, et al. Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis. Mol Cell. 2006;23:401-12 pubmed
    ..Finally, the data showed that polypyrimidine tract binding protein (PTB, a known IRES trans-acting factor or ITAF) is pivotal in regulating the apoptotic process by controlling IRES ..
  7. Patton J, Mayer S, Tempst P, Nadal Ginard B. Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev. 1991;5:1237-51 pubmed
    ..Using a biochemical complementation assay, we have found that this protein, along with a 100-kD protein, exists as part of a large complex that is required to rescue splicing from depleted nuclear extracts. ..
  8. Pickering B, Mitchell S, Evans J, Willis A. Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo. Nucleic Acids Res. 2003;31:639-46 pubmed
    ..Two proteins, poly r(C) binding protein 1 (PCBP1) and polypyrimidine tract binding protein (PTB), were found to increase the activity of the Bag-1 IRES in vitro and in vivo...
  9. Mitchell S, Spriggs K, Coldwell M, Jackson R, Willis A. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell. 2003;11:757-71 pubmed
    We have shown previously that polypyrimidine tract binding protein 1 (PTB) binds and activates the Apaf-1 internal ribosome entry segment (IRES) when the protein upstream of N-ras (unr) is prebound...
  10. Lin J, Tarn W. Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. Mol Cell Biol. 2005;25:10111-21 pubmed
    ..By contrast, the splicing regulator polypyrimidine tract binding protein (PTB) excluded these exons; moreover, RBM4 antagonized this PTB-mediated exon exclusion likely by competing with PTB for ..
  11. Robinson F, Smith C. A splicing repressor domain in polypyrimidine tract-binding protein. J Biol Chem. 2006;281:800-6 pubmed
    Polypyrimidine tract-binding protein (PTB) is an hnRNP with four RRM type domains...
  12. Xue Y, Zhou Y, Wu T, Zhu T, Ji X, Kwon Y, et al. Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell. 2009;36:996-1006 pubmed publisher
    ..The polypyrimidine tract-binding protein PTB is a well-characterized splicing repressor, but PTB knockdown causes both exon inclusion and skipping...
  13. Kuranaga Y, Sugito N, Shinohara H, Tsujino T, Taniguchi K, Komura K, et al. SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..Overexpression of SRSF3, as well as that of another splicer, polypyrimidine tract binding protein 1 (PTBP1) and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), in clinical cancer samples ..
  14. Naguleswaran A, Gunasekera K, Schimanski B, Heller M, Hemphill A, Ochsenreiter T, et al. Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure. MBio. 2015;6:e00114 pubmed publisher
    ..We propose that TbRRM1 regulates RNA polymerase II-driven gene expression both cotranscriptionally, by facilitating transcription and efficient splicing, and posttranscriptionally, via its interaction with nuclear mRNAs. ..
  15. Zhang L, Yang Z, Trottier J, Barbier O, Wang L. Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay. Hepatology. 2017;65:604-615 pubmed publisher
    ..MEG 3RNA followed by mass spectrometry, we identified RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) as a MEG3 interacting protein and validated their interaction by RNA immunoprecipitation (RIP)...
  16. Kim S, Lee K, Kim D, Kwak E, Kim S, Kim K. Rhythmic control of mRNA stability modulates circadian amplitude of mouse Period3 mRNA. J Neurochem. 2015;132:642-56 pubmed publisher
    ..identify three proteins - heterogeneous nuclear ribonucleoprotein (hnRNP) K, polypyrimidine tract-binding protein (PTB), and hnRNP D - that bind to mPer3 mRNA 3'-UTR...
  17. FREDERIKSE P, Nandanoor A, Kasinathan C. PTBP-dependent PSD-95 and CamKIIα alternative splicing in the lens. Mol Vis. 2014;20:1660-7 pubmed
    ..During neurogenesis, miR-124 is expressed that suppresses PTBP1 and promotes these splicing events...
  18. Kishor A, Ge Z, Hogg J. hnRNP L-dependent protection of normal mRNAs from NMD subverts quality control in B cell lymphoma. EMBO J. 2019;38: pubmed publisher
    ..Integrating these findings with the previously defined role of polypyrimidine tract binding protein 1 in NMD evasion enables enhanced prediction of transcript susceptibility to NMD...
  19. Anderson E, Catnaigh P. Regulation of the expression and activity of Unr in mammalian cells. Biochem Soc Trans. 2015;43:1241-6 pubmed publisher
    ..some unr transcripts can occur by internal initiation and is regulated in a cell-cycle-dependent manner; binding of PTB (polypyrimidine tract-binding protein) and Unr to the 5'-UTR inhibits translation, but these are displaced by ..
  20. Masuda K, Abdelmohsen K, Gorospe M. RNA-binding proteins implicated in the hypoxic response. J Cell Mol Med. 2009;13:2759-69 pubmed publisher
    ..The RBPs HuR (human antigen R) and PTB (polypyrimidine tract-binding protein) associate with mRNAs encoding hypoxia-response proteins such as HIF-1alpha ..
  21. Caruso P, Dunmore B, Schlosser K, Schoors S, Dos Santos C, Perez Iratxeta C, et al. Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017;136:2451-2467 pubmed publisher
    ..with a tiered systems biology approach, is responsible for increased expression of the splicing factor PTBP1 (polypyrimidine tract binding protein), resulting in alternative splicing of pyruvate kinase muscle isoforms 1 ..
  22. Liu W, Lin Y, Yan X, Ding Y, Wu Y, Chen W, et al. Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression. FASEB J. 2015;29:1113-23 pubmed publisher
  23. Taniguchi K, Sugito N, Shinohara H, Kuranaga Y, Inomata Y, Komura K, et al. Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression. Int J Mol Sci. 2018;19: pubmed publisher
    ..microRNAs (miRNAs, MIR) regulate PKM isoform expression through direct targeting of polypyrimidine tract binding protein 1 (PTBP1), which is the splicer responsible for PKM2-dominant expression...
  24. Yi B, Ozerova M, Zhang G, Yan G, Huang S, Sun J. Post-Transcriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Polypyrimidine Tract-Binding Protein 1. Arterioscler Thromb Vasc Biol. 2015;35:2153-60 pubmed publisher
    ..These results indicate that PTB1 is essential for regulating eNOS expression at post-transcriptional levels and suggest a novel therapeutic target for treatment of vascular diseases associated with inflammatory endothelial dysfunction. ..
  25. Castillo J, Castrillón J, Diosa Toro M, Betancur J, St Laurent G, Smit J, et al. Complex interaction between dengue virus replication and expression of miRNA-133a. BMC Infect Dis. 2016;16:29 pubmed publisher
    ..Furthermore, the expression of polypyrimidine tract binding protein (PTB), a protein involved in DENV replication, was analyzed by western blot...
  26. Dong L, Nian H, Shao Y, Zhang Y, Li Q, Yi Y, et al. PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy. Cell Tissue Res. 2015;360:233-43 pubmed publisher
  27. Szychowski J, Owen J, Hankins G, Iams J, Sheffield J, Perez Delboy A, et al. Can the optimal cervical length for placing ultrasound-indicated cerclage be identified?. Ultrasound Obstet Gynecol. 2016;48:43-7 pubmed publisher
    ..CL) cut-offs for the efficacy of ultrasound-indicated cerclage in women with previous spontaneous preterm birth (PTB)...
  28. Van Nostrand E, Huelga S, Yeo G. Experimental and Computational Considerations in the Study of RNA-Binding Protein-RNA Interactions. Adv Exp Med Biol. 2016;907:1-28 pubmed publisher
  29. Matsye P, Zheng L, Si Y, Kim S, Luo W, Crossman D, et al. HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases. Glia. 2017;65:945-963 pubmed publisher
    ..These findings underscore an important role for HuR in sculpting the molecular signature and phenotype of activated microglia, and as a possible therapeutic target in ALS and other neurodegenerative diseases. ..
  30. Brauß T, Winslow S, Lampe S, Scholz A, Weigert A, Dehne N, et al. The RNA-binding protein HuR inhibits expression of CCL5 and limits recruitment of macrophages into tumors. Mol Carcinog. 2017;56:2620-2629 pubmed publisher
    ..As macrophage infiltration is associated with poor prognosis, our findings underline the highly cell-type and context specific role of HuR in tumorigenesis. ..
  31. Wan R, Zhou L, Yang H, Zhou Y, Ye S, Zhao Q, et al. Involvement of FMRP in Primary MicroRNA Processing via Enhancing Drosha Translation. Mol Neurobiol. 2017;54:2585-2594 pubmed publisher
    ..Thus, our data suggest that FMRP is involved in pri-miRNA processing via enhancing DROSHA expression that may play an important role in fragile X syndrome. ..
  32. Rentas S, Holzapfel N, Belew M, Pratt G, Voisin V, Wilhelm B, et al. Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells. Nature. 2016;532:508-511 pubmed publisher
    ..Our study gives mechanistic insight into RNA networks controlled by RNA-binding proteins that underlie self-renewal and provides evidence that manipulating such networks ex vivo can enhance the regenerative potential of human HSCs. ..
  33. Wang S, Bai G, Wang S, Yang L, Yang F, Wang Y, et al. Chloroplast RNA-Binding Protein RBD1 Promotes Chilling Tolerance through 23S rRNA Processing in Arabidopsis. PLoS Genet. 2016;12:e1006027 pubmed publisher
    ..Together, our study identifies RBD1 as a regulator of 23S rRNA processing and reveals the importance of chloroplast function especially protein translation in chilling tolerance. ..
  34. Zhuo C, Jiang R, Lin X, Shao M. LncRNA H19 inhibits autophagy by epigenetically silencing of DIRAS3 in diabetic cardiomyopathy. Oncotarget. 2017;8:1429-1437 pubmed publisher
    ..In conclusion, our study suggested that H19 could inhibit autophagy in cardiomyocytes by epigenetically silencing of DIRAS3, which might provide novel insights into understanding the molecular mechanisms of diabetic cardiomyopathy. ..
  35. Naderi M, Hashemi M, Mirshekari H, Bahari G, Taheri M. Toll-like Receptor 1 Polymorphisms Increased the Risk of Pulmonary Tuberculosis in an Iranian Population Sample. Biomed Environ Sci. 2016;29:825-828 pubmed publisher
    A case-control study was carried out that involved 203 individuals diagnosed with pulmonary tuberculosis (PTB) and 203 healthy subjects...
  36. Zhou A, Xie A, Kim T, Liu H, Shi G, Kang G, et al. HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure. Heart Rhythm. 2018;15:1072-1080 pubmed publisher
    ..Increasing mRNA stability to increase ion channel currents may correct a fundamental defect in HF and represent a new paradigm in antiarrhythmic therapy. ..
  37. Hosoda N, Kim Y, Lejeune F, Maquat L. CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol. 2005;12:893-901 pubmed
    ..SMD depends on the recruitment of Upf1 by the RNA-binding protein Stau1 but does not depend on the other Upf proteins. We find that CBP80 interacts with Upf1 and promotes the interaction of Upf1 with Upf2 but not with Stau1...
  38. Cannell I, Merrick K, Morandell S, Zhu C, Braun C, Grant R, et al. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell. 2015;28:623-637 pubmed publisher
    ..Here we show that the RNA binding protein hnRNPA0 is the "successor" to p53 for checkpoint control...
  39. Jain S, Kilgore M, Edwards R, Owen J. Revisiting the cost-effectiveness of universal cervical length screening: importance of progesterone efficacy. Am J Obstet Gynecol. 2016;215:101.e1-7 pubmed publisher
    Preterm birth (PTB) is a significant cause of neonatal morbidity and mortality. Studies have shown that vaginal progesterone therapy for women diagnosed with shortened cervical length can reduce the risk of PTB...
  40. Motodate R, Saito Y, Hata S, Suzuki T. Expression and localization of X11 family proteins in neurons. Brain Res. 2016;1646:227-234 pubmed publisher
    ..Each of these molecules is an adaptor protein that contains a phosphotyrosine interaction/binding (PI/PTB) and two PDZ domains in its carboxy-terminal region...
  41. Nakamura K, Sawada K, Yoshimura A, Kinose Y, Nakatsuka E, Kimura T. Clinical relevance of circulating cell-free microRNAs in ovarian cancer. Mol Cancer. 2016;15:48 pubmed publisher
  42. Cortés Guiral D, Pastor Iodate C, Díaz Del Arco C, Del Puerto Nevado L, Fernández Aceñero M. CPEB4 immunohistochemical expression is associated to prognosis in stage IV colorectal carcinoma. Pathol Res Pract. 2017;213:639-642 pubmed publisher
    The cytoplasmic polyadenylation element binding protein 4 (CPEB4) is a RNA binding protein and translational regulator...
  43. Maynard C, Hall K. Interactions between PTB RRMs induce slow motions and increase RNA binding affinity. J Mol Biol. 2010;397:260-77 pubmed publisher
    Polypyrimidine tract binding protein (PTB) participates in a variety of functions in eukaryotic cells, including alternative splicing, mRNA stabilization, and internal ribosomal entry site-mediated translation initiation...
  44. Chow W, Cheung H, Li W, Lau K. FE65: Roles beyond amyloid precursor protein processing. Cell Mol Biol Lett. 2015;20:66-87 pubmed publisher
    ..three protein interaction domains, including an N-terminal WW domain and two C-terminal phosphotyrosine-binding (PTB) domains. It is capable of mediating the assembly of multimolecular complexes...
  45. Kazemier B, Miller E, Grobman W, Mol B. Variation in preterm birth rate and the role of short cervical length across two populations: a comparative cohort study. J Perinatol. 2016;36:516-21 pubmed publisher
    To examine variation in preterm birth (PTB) rates between nulliparous women from two different populations and to investigate the contribution of short cervical length to any observed variation...
  46. Deng W, Cha J, Yuan J, Haraguchi H, Bartos A, Leishman E, et al. p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. J Clin Invest. 2016;126:2941-54 pubmed publisher
    Inflammation and oxidative stress are known risk factors for preterm birth (PTB); however, the mechanisms and pathways that influence this condition are not fully described...
  47. Lal P, Cerofolini L, D Agostino V, Zucal C, Fuccio C, Bonomo I, et al. Regulation of HuR structure and function by dihydrotanshinone-I. Nucleic Acids Res. 2017;45:9514-9527 pubmed publisher
    ..In vivo, DHTS potently inhibited xenograft tumor growth in a HuR-dependent model without systemic toxicity. ..
  48. Wosu A, Gelaye B, Williams M. Maternal history of childhood sexual abuse and preterm birth: an epidemiologic review. BMC Pregnancy Childbirth. 2015;15:174 pubmed publisher
    ..However, the effects of CSA on preterm delivery (PTB), a leading cause of neonatal mortality, remain poorly understood...
  49. Danan C, Manickavel S, Hafner M. PAR-CLIP: A Method for Transcriptome-Wide Identification of RNA Binding Protein Interaction Sites. Methods Mol Biol. 2016;1358:153-73 pubmed publisher
  50. Leon L, Solanky N, Stalman S, Demetriou C, Abu Amero S, Stanier P, et al. A new biological and clinical resource for research into pregnancy complications: The Baby Bio Bank. Placenta. 2016;46:31-37 pubmed publisher
    ..Fetal growth restriction (FGR), recurrent miscarriage (RM), preterm birth (PTB), and pre-eclampsia (PE) are the most common pregnancy complications encountered in the UK and these outcomes can ..
  51. Song J, Li J, Liu H, Gan Y, Sun Y, Yu M, et al. A genetic variant in the placenta-derived MHC class I chain-related gene A increases the risk of preterm birth in a Chinese population. Hum Genet. 2017;136:1375-1384 pubmed publisher
    Preterm birth (PTB) is a predominant contributor to neonatal mortality and morbidity worldwide. However, the pathophysiology of PTB is not well-understood...
  52. Yu R, Yang D, Lei S, Wang X, Meng X, Xue B, et al. HMGB1 Promotes Hepatitis C Virus Replication by Interaction with Stem-Loop 4 in the Viral 5' Untranslated Region. J Virol. 2015;90:2332-44 pubmed publisher
    ..HMGB1 appears to play an important role in HCV-related diseases, and further investigation is warranted to elucidate the specific actions of HMGB1 in HCV pathogenesis. ..
  53. Slone S, Anthony S, Wu X, Benoit J, AUBE J, Xu L, et al. Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy. Cell Signal. 2016;28:1735-41 pubmed publisher
    The RNA binding protein Human antigen R (HuR) interacts with specific AU-rich domains in target mRNAs and is highly expressed in many cell types, including cardiomyocytes. However, the role of HuR in cardiac physiology is largely unknown...
  54. Satoh R, Matsumura Y, Tanaka A, Takada M, Ito Y, Hagihara K, et al. Spatial regulation of the KH domain RNA-binding protein Rnc1 mediated by a Crm1-independent nuclear export system in Schizosaccharomyces pombe. Mol Microbiol. 2017;104:428-448 pubmed publisher
    ..Collectively, the functional Rae1-dependent mRNA export system may influence the cytoplasmic localization and function of Rnc1. ..
  55. Xu J, Chen Y, Qian L, Mu R, Yuan X, Fang H, et al. A Novel RNA-Binding Protein Involves ABA Signaling by Post-transcriptionally Repressing ABI2. Front Plant Sci. 2017;8:24 pubmed publisher
    ..Together, it is suggested that SRP1 is involved in the ABA signaling by post-transcriptionally repressing ABI2 expression in Arabidopsis. ..
  56. Kirkeby C, Græsbøll K, Nielsen S, Toft N, Halasa T. Epidemiological and economic consequences of purchasing livestock infected with Mycobacterium avium subsp. paratuberculosis. BMC Vet Res. 2017;13:202 pubmed publisher
    Paratuberculosis (PTB) is a chronic disease which may lead to reduced milk yield, lower animal welfare and death in cattle. The causative agent is Mycobacterium avium subsp. paratuberculosis (MAP)...
  57. da Silva Lopes K, Ota E, Shakya P, Dagvadorj A, Balogun O, Pena Rosas J, et al. Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews. BMJ Glob Health. 2017;2:e000389 pubmed publisher
    ..the immediate determinants of nutrition) and nutrition-sensitive (addressing the underlying cause of undernutrition) interventions to reduce the risk of LBW and/or its components: preterm birth (PTB) and small-for-gestational age (SGA).
  58. Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, et al. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Mol Cell. 2016;61:153-60 pubmed publisher
    ..These results reveal a surprising role for Lin28A in transcriptional regulation via epigenetic DNA modifications and have implications for understanding mechanisms underlying versatile functions of Lin28A in mammalian systems. ..
  59. Coelho M, Ascher D, Gooding C, Lång E, Maude H, Turner D, et al. Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins. Biochem Soc Trans. 2016;44:1058-65 pubmed publisher
    Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm...
  60. Castagnola S, Bardoni B, Maurin T. The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality?. Front Synaptic Neurosci. 2017;9:15 pubmed publisher
  61. Song Y, Feng W, Shi G, Chen C, Zhang Y. RNA-binding protein HuR regulates hsa-let-7c expression by its RNA recognition motif. Sheng Li Xue Bao. 2018;70:1-8 pubmed
    ..These results suggest that RRM3 is crucial for HuR mediating mature hsa-let-7c expression. Collectively, these findings proposed a novel role of HuR in biogenesis of miRNAs, possibly by way of post-transcriptional regulation of miRNAs. ..
  62. Simsek D, Tiu G, Flynn R, Byeon G, Leppek K, Xu A, et al. The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Cell. 2017;169:1051-1065.e18 pubmed publisher
    ..Therefore, RAPs interconnect one of life's most ancient molecular machines with diverse cellular processes, providing an additional layer of regulatory potential to protein expression. ..
  63. Mugo E, Clayton C. Expression of the RNA-binding protein RBP10 promotes the bloodstream-form differentiation state in Trypanosoma brucei. PLoS Pathog. 2017;13:e1006560 pubmed publisher
  64. Graber T, Freemantle E, Anadolu M, Hébert Seropian S, MacAdam R, Shin U, et al. UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule. J Neurosci. 2017;37:9116-9131 pubmed publisher
    ..Moreover, UPF1 and its interaction with the RNA binding protein STAU2 are necessary for proper transport and local translation from a prototypical RNA granule substrate ..
  65. Milano M, Moraes M, Rodenbusch R, Carvalho C, Delcroix M, Mousquer G, et al. Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population. PLoS ONE. 2016;11:e0147814 pubmed publisher
    ..TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility...
  66. Santamaria N, Alhothali M, Alfonso M, Breydo L, Uversky V. Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis. Cell Mol Life Sci. 2017;74:1297-1318 pubmed publisher
  67. Almeida J, Mulready Ward C, Bettegowda V, Ahluwalia I. Racial/Ethnic and nativity differences in birth outcomes among mothers in New York City: the role of social ties and social support. Matern Child Health J. 2014;18:90-100 pubmed publisher
    Immigrants have lower rates of low birth weight (LBW) and to some extent preterm birth (PTB), than their US-born counterparts. This pattern has been termed the 'immigrant health paradox'...
  68. Angenstein F, Evans A, Settlage R, Moran S, Ling S, Klintsova A, et al. A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. J Neurosci. 2002;22:8827-37 pubmed
  69. Williams P, Krug M, McMillan E, Peake J, Davis T, Cocklin S, et al. Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis. Mol Biol Cell. 2016;27:2341-50 pubmed publisher
  70. Yamazumi Y, Sasaki O, Imamura M, Oda T, Ohno Y, Shiozaki Sato Y, et al. The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation. Cell Rep. 2016;16:2456-71 pubmed publisher
    ..Here, we show that the RNA binding protein Mex-3B plays a critical role in the induction of IL-33 in the development of allergic airway inflammation...
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    ..78±0.16 (n=21 fields) at peripheral retinal locations (eccentricity >7 mm). This investigation demonstrates that RBPMS could serve as a valuable RGC specific marker for future investigations in this field. ..
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    ..The cellular role of CCM1 protein remains inadequately expounded. Both phosphotyrosine binding (PTB) and pleckstrin homology (PH) domains were recognized as structurally related but functionally distinct domains...
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    PUM1 is an RNA binding protein shown to regulate the stability and function of mRNAs bearing a specific sequence...
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    Vaginal administration of micronized progesterone (utrogestan capsule, UG) reduces the risk of preterm birth (PTB) in asymptomatic women with a sonographic short cervix at mid-trimester or with a prior history of spontaneous PTB; however,..
  75. Blum J, Chen L, Zelikoff J. Exposure to Ambient Particulate Matter during Specific Gestational Periods Produces Adverse Obstetric Consequences in Mice. Environ Health Perspect. 2017;125:077020 pubmed publisher
    ..5) during pregnancy with preterm birth (PTB) and low birth weight (LBW) but disagree over which time frames are most sensitive, or if effects are cumulative.
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    ..These data collectively indicate that Qki5 regulates communication between neural stem cells by mediating numerous RNA processing events and suggest new links between splicing regulation and neural stem cell states. ..
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    ..This discovery suggests avenues for therapeutic modulation of innate immune response in resident microglia. ..
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    The double-stranded RNA binding protein Staufen1 (Stau1) is involved in diverse gene expression pathways...
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    ..We show that the polypyrimidine tract binding protein 1 (PTBP1) shields specific retroviral and cellular transcripts from NMD...
  80. Sugiyama T, Taniguchi K, Matsuhashi N, Tajirika T, Futamura M, Takai T, et al. MiR-133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle-splicer polypyrimidine tract-binding protein 1. Cancer Sci. 2016;107:1767-1775 pubmed publisher
    ..This effect is regulated mainly by polypyrimidine tract-binding protein 1 (PTBP1), which is a splicer of the mRNA for the rate-limiting enzymes of glycolysis, pyruvate kinase muscle 1 and 2 (PKM1 ..
  81. Payne M, Ireland D, Watts R, Nathan E, Furfaro L, Kemp M, et al. Ureaplasma parvum genotype, combined vaginal colonisation with Candida albicans, and spontaneous preterm birth in an Australian cohort of pregnant women. BMC Pregnancy Childbirth. 2016;16:312 pubmed the vagina during pregnancy has previously been associated with preterm birth (PTB)...
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    Hfq is a bacterial RNA binding protein that carries out several roles in genetic expression regulation, mainly at the post-transcriptional level. Previous studies have shown its importance in growth and virulence of bacteria...
  83. Cao J, Han X, Qi X, Jin X, Li X. TUG1 promotes osteosarcoma tumorigenesis by upregulating EZH2 expression via miR-144-3p. Int J Oncol. 2017;51:1115-1123 pubmed publisher
    ..In conclusion, our results showed that TUG1 plays an important role in osteosarcoma development through miRNA-144-3p/EZH2/Wnt/β-catenin pathway. ..
  84. Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, et al. 3'UTR Length-Dependent Control of SynGAP Isoform ?2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function. Cell Rep. 2017;20:3071-3084 pubmed publisher
    ..Our findings establish an important link between FUS and ELAVL proteins for mRNA stability control and indicate that this mechanism is crucial for the maintenance of synaptic morphology and cognitive function. ..
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    Pleural tuberculosis (pTB) is a grave form of extrapulmonary tuberculosis. Microbiological tests are usually found to be inadequate for pTB diagnosis...
  86. Navarro F, Chakravarty P, Nurse P. Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast. J Cell Sci. 2017;130:4144-4154 pubmed publisher
    ..We propose that Zfs1 functions as an integrator of nutrient information to modulate sexual differentiation, contributing to the establishment of the differentiation-activating threshold. ..
  87. Zhao X, Oberg D, Rush M, Fay J, Lambkin H, Schwartz S. A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding protein. J Virol. 2005;79:4270-88 pubmed
    ..These mRNAs would therefore be more efficiently translated into E1 and E4 than previously described HPV-16 E1 and E4 mRNAs on which E1 and E4 are preceded by both E6 and E7 AUGs. ..
  88. Xue Y, Ouyang K, Huang J, Zhou Y, Ouyang H, Li H, et al. Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell. 2013;152:82-96 pubmed publisher
    ..Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-..
  89. Schlissel G, Krzyzanowski M, Caudron F, Barral Y, Rine J. Aggregation of the Whi3 protein, not loss of heterochromatin, causes sterility in old yeast cells. Science. 2017;355:1184-1187 pubmed publisher
    ..We propose that aging phenotypes previously attributed to loss of heterochromatin silencing are instead caused by aggregation of the Whi3 cell cycle regulator. ..
  90. Zhang B, Yang R, Liang S, Wang J, Chang J, Hu K, et al. Association between prenatal care utilization and risk of preterm birth among Chinese women. J Huazhong Univ Sci Technolog Med Sci. 2017;37:605-611 pubmed publisher
    ..This study was to estimate the association between prenatal care utilization (PCU) and preterm birth (PTB), and to investigate if medical conditions during pregnancy modified the association...
  91. Katoch A, George B, Iyyappan A, Khan D, Das S. Interplay between PTB and miR-1285 at the p53 3'UTR modulates the levels of p53 and its isoform ?40p53?. Nucleic Acids Res. 2017;45:10206-10217 pubmed publisher
    ..We report that the trans acting factor, Polypyrimidine Tract Binding protein (PTB), also interacts specifically with 3'UTR of p53 mRNA and positively regulates expression of p53 isoforms...
  92. Nandre J, Patil S, Sahoo S, Pradeep C, Churakov A, Yu F, et al. A chemosensor for micro- to nano-molar detection of Ag+ and Hg2+ ions in pure aqueous media and its applications in cell imaging. Dalton Trans. 2017;46:14201-14209 pubmed publisher
    The pyridine substituted thiourea derivative PTB-1 was synthesized and characterized by spectroscopic techniques as well as by single crystal X-ray crystallography...