PSMD4

Summary

Gene Symbol: PSMD4
Description: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Alias: AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, 26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit S5A, RPN10 homolog, S5a/antisecretory factor protein, angiocidin, antisecretory factor 1, multiubiquitin chain-binding protein
Species: human

Top Publications

  1. pmc Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
    M Lamar Seibenhener
    Program in Cell and Molecular Biosciences, Department of Biological Sciences, Auburn University, AL 36849, USA
    Mol Cell Biol 24:8055-68. 2004
  2. pmc Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain
    Eri Sakata
    Department of Structural Biology and Biomolecular Engineering, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    EMBO Rep 4:301-6. 2003
  3. pmc Structural determinants for the binding of ubiquitin-like domains to the proteasome
    Thomas D Mueller
    Department of Chemistry and Biochemistry, 405 Hilgard Avenue, PO Box 951569, University of California, Los Angeles, CA 90095 1569, USA
    EMBO J 22:4634-45. 2003
  4. pmc Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP
    K Matthew Scaglione
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Cell 43:599-612. 2011
  5. pmc Solution structure of the E3 ligase HOIL-1 Ubl domain
    Steven A Beasley
    Department of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Protein Sci 21:1085-92. 2012
  6. ncbi Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a
    Kylie J Walters
    Department of Pathology and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 41:1767-77. 2002
  7. doi Parkin directly modulates 26S proteasome activity
    Ji Won Um
    Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea
    J Neurosci 30:11805-14. 2010
  8. pmc The UBL domain of PLIC-1 regulates aggresome formation
    Renu Heir
    Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montreal, Quebec H3A2B2, Canada
    EMBO Rep 7:1252-8. 2006
  9. pmc Differential interaction of the E3 ligase parkin with the proteasomal subunit S5a and the endocytic protein Eps15
    Susan S Safadi
    Department of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 285:1424-34. 2010
  10. pmc HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome
    Ge Li
    Department of Pathology, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11371. 2010

Research Grants

Detail Information

Publications169 found, 100 shown here

  1. pmc Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
    M Lamar Seibenhener
    Program in Cell and Molecular Biosciences, Department of Biological Sciences, Auburn University, AL 36849, USA
    Mol Cell Biol 24:8055-68. 2004
    ..Altogether, our results support the hypothesis that p62 may act as a critical ubiquitin chain-targeting factor that shuttles substrates for proteasomal degradation...
  2. pmc Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain
    Eri Sakata
    Department of Structural Biology and Biomolecular Engineering, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    EMBO Rep 4:301-6. 2003
    ..Inspection of chemical-shift-perturbation data showed that the parkin Ubl domain binds the Rpn10 subunit of 26S proteasomes via the region of parkin that includes position 42...
  3. pmc Structural determinants for the binding of ubiquitin-like domains to the proteasome
    Thomas D Mueller
    Department of Chemistry and Biochemistry, 405 Hilgard Avenue, PO Box 951569, University of California, Los Angeles, CA 90095 1569, USA
    EMBO J 22:4634-45. 2003
    ..The Ubl domain binds with high affinity to the second ubiquitin-interacting motif (UIM) of the S5a subunit of the proteasome...
  4. pmc Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP
    K Matthew Scaglione
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Cell 43:599-612. 2011
    ..In addition, the results shed light on disease pathogenesis in SCA3, a neurodegenerative disorder caused by polyglutamine expansion in ataxin-3...
  5. pmc Solution structure of the E3 ligase HOIL-1 Ubl domain
    Steven A Beasley
    Department of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Protein Sci 21:1085-92. 2012
    ..Further, the Ubl domain of both HOIL-1 and parkin has been shown to interact with the S5a subunit of the 26S proteasome...
  6. ncbi Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a
    Kylie J Walters
    Department of Pathology and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 41:1767-77. 2002
    ..We have focused on how the S5a component of the 19S complex interacts with different ubiquitin-like (ubl) modules, to advance our understanding of ..
  7. doi Parkin directly modulates 26S proteasome activity
    Ji Won Um
    Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea
    J Neurosci 30:11805-14. 2010
    ..The current findings point to a novel role for parkin for 26S proteasome assembly and suggest that parkin mutations contribute to the proteasomal dysfunction in PD...
  8. pmc The UBL domain of PLIC-1 regulates aggresome formation
    Renu Heir
    Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montreal, Quebec H3A2B2, Canada
    EMBO Rep 7:1252-8. 2006
    ..is a ubiquitin-like protein that binds to the ubiquitin-interacting motif (UIM) of the proteasomal subunit S5a. Here, we show that PLIC-1 also binds to the UIM proteins ataxin 3--a deubiquitinating enzyme--HSJ1a--a co-..
  9. pmc Differential interaction of the E3 ligase parkin with the proteasomal subunit S5a and the endocytic protein Eps15
    Susan S Safadi
    Department of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 285:1424-34. 2010
    ..The N-terminal ubiquitin-like domain (Ubld) of parkin functions with the S5a proteasomal subunit, positioning substrate proteins for degradation...
  10. pmc HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome
    Ge Li
    Department of Pathology, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11371. 2010
    ..further confirmed in mammalian cells where Vpr associates with the mammalian orthologues of fission yeast Mts4 and S5a. Consistently, depletion of hHR23A interrupts interaction of Vpr with proteasome in mammalian cells...
  11. ncbi The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up
    Brigit E Riley
    Department of Biochemistry, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:42290-301. 2004
    ..Similar to other UbL-containing proteins, the UbL of A1Up is essential for the interaction of A1Up with the S5a subunit of the 19S proteasome...
  12. ncbi Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome
    H Hiyama
    Institute for Molecular and Cellular Biology, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 274:28019-25. 1999
    ..that the human NER factor hHR23B as well as another human homolog of RAD23, hHR23A, interact specifically with S5a, a subunit of the human 26 S proteasome using the yeast two-hybrid system...
  13. ncbi Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1
    T Kamitani
    Department of Cardiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:46655-60. 2001
    ..276, 20603-20609). Here, we show that NUB1 possesses a ubiquitin-like domain at the N-terminal region and binds to S5a of the 19 S proteasome activator (PA700)...
  14. ncbi Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1
    Jing Zhou
    Temple University, Center for Neurovirology and Cancer Biology, 354 Biology Life Sciences Building 015 96, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 92:125-46. 2004
    ..The purified recombinant protein, termed angiocidin, is a potent inhibitor of tumor growth of Lewis Lung carcinoma in vivo and tumor invasion and angiogenesis in ..
  15. ncbi A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling
    Lara Fallon
    Centre for Neuronal Survival and Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Nat Cell Biol 8:834-42. 2006
    ..Considering the role of Akt in neuronal survival, our results have broad new implications for understanding the pathogenesis of Parkinson's disease...
  16. pmc An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine
    T Lewis
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 74:1275-85. 2000
    ..All pigs previously infected with Delta9GL survived infection when subsequently challenged with a lethal dose of virulent parental MAL. Thus, ASFV 9GL gene deletion mutants may prove useful as live-attenuated ASF vaccines.
  17. ncbi [Influence of angiotensin on the secretion of aldosterone in idiopathic hyperaldosteronism]
    M Salvador
    , , Toulouse
    Arch Mal Coeur Vaiss 80:992-4. 1987
    ..an increase of adrenal sensitivity to angiotensin II infusions, and isolated an aldosterone-stimulating factor (ASF). Plasma aldosterone levels were related to increased ASF concentrations but there was no link between PRA and ASF...
  18. ncbi Prospective pulmonary function evaluation following open thoracotomy for anterior spinal fusion in adolescent idiopathic scoliosis
    E J Graham
    Washington University, Department of Orthopaedic Surgery, St Louis, MO, USA
    Spine (Phila Pa 1976) 25:2319-25. 2000
    ..sequential pulmonary function tests (PFTs) at a minimum 2-year follow-up after an open anterior spinal fusion (ASF) with instrumentation for thoracic AIS...
  19. doi Assessment of interactions between African swine fever virus, bushpigs (Potamochoerus larvatus), Ornithodoros ticks and domestic pigs in north-western Madagascar
    J Ravaomanana
    FOFIFA, Malagasy Centre for Research in Agronomy, Antananarivo, Madagascar
    Transbound Emerg Dis 58:247-54. 2011
    Since its introduction in Madagascar in 1998, African swine fever (ASF) has severely affected national pig production and persists as a common disease in that country...
  20. doi Design and verification of a highly reliable Linear-After-The-Exponential PCR (LATE-PCR) assay for the detection of African swine fever virus
    B Ronish
    Department of Biology, Brandeis University, Waltham, MA 02454 9110, USA
    J Virol Methods 172:8-15. 2011
    ..African swine fever virus (ASFV) is a highly pathogenic DNA virus that is the causative agent of African swine fever (ASF), an infectious disease of domestic and wild pigs of all breeds and ages, causing a range of syndromes...
  21. ncbi Differential expression of the splicing regulatory factor genes during two-step chemical transformation in a BALB/3T3-derived cell line, MT-5
    T Maeda
    Department of Radiology and Radiation Oncology, Osaka University School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Carcinogenesis 20:2341-4. 1999
    ..Gene expression of three splicing regulatory factors, alternative splicing factor/splicing factor 2 (ASF/SF2), heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and the 65 kDa subunit of U2 small nuclear ..
  22. ncbi Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters
    F Martel
    Department of Biochemistry, Faculty of Medicine, Porto, Portugal
    Naunyn Schmiedebergs Arch Pharmacol 363:40-9. 2001
    ..organic cations, by testing the possibility of involvement of known members of the amphiphilic solute facilitator (ASF) family in this process...
  23. ncbi Alcohol-free mouthrinse solutions to reduce supragingival plaque regrowth and vitality. A controlled clinical study
    N B Arweiler
    Department of Periodontology and Conservative Dentistry, University of the Saarland, Homburg, Germany
    J Clin Periodontol 28:168-74. 2001
    ..of this study was to evaluate the clinical and antibacterial properties of alcohol-free mouthrinses, an amine fluoride/stannous fluoride mouthrinse (ASF) and two triclosan solutions in comparison with a chlorhexidine and a placebo rinse.
  24. pmc An RNA splicing enhancer-like sequence is a component of a splicing inhibitor element from Rous sarcoma virus
    L M McNally
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mol Cell Biol 18:3103-11. 1998
    ..The second is a purine-rich region in the 5' half that interacts with the splicing factor SF2/ASF. In this study we investigated the possibility that this purine-rich region provides an RNA splicing enhancer ..
  25. pmc Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production
    Sandrine Jacquenet
    Laboratoire de Médecine et Thérapeutique Moléculaire, INSERM CIC9501, 15 rue du Bois de la Champelle, 54500 Vandoeuvre les Nancy, France
    Retrovirology 2:33. 2005
    ..and virion production, we used a human cell line expressing high levels of complete HIV-1 and either one of the ASF/SF2, SC35, and 9G8 SR proteins...
  26. pmc Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
    Patrick Schreiner
    Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, D 85747 Garching, Germany
    Nature 453:548-52. 2008
    ..proteasome recognizes its substrates, as the only established ubiquitin receptor intrinsic to the proteasome is Rpn10/S5a (ref. 1), which is not essential for ubiquitin-mediated protein degradation in budding yeast...
  27. ncbi Serum concentrations of C-reactive protein, serum amyloid A, and haptoglobin in pigs inoculated with African swine fever or classical swine fever viruses
    Pedro J Sánchez-Cordón
    Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Edificio de Sanidad Animal, Campus de Rabanales, 14014, Cordoba, Spain
    Am J Vet Res 68:772-7. 2007
    ..serum concentrations of the selected acute-phase proteins (APPs) haptoglobin, serum amyloid A (SAA), and C-reactive protein (CRP) in pigs experimentally inoculated with classical swine fever (CSF) and African swine fever (ASF) viruses.
  28. pmc The persistence of African swine fever virus in field-infected Ornithodoros erraticus during the ASF endemic period in Portugal
    Fernando S Boinas
    Centro de Investigação Interdisciplinar em Medicina Veterinária, Faculdade de Medicina Veterinária da Universidade Técnica de Lisboa, Lisboa, Portugal
    PLoS ONE 6:e20383. 2011
    African swine fever (ASF) is an important disease of pigs and outbreaks of ASF have occurred in Europe on multiple occasions...
  29. pmc Gait in thoracolumbar/lumbar adolescent idiopathic scoliosis: effect of surgery on gait mechanisms
    Philippe Mahaudens
    Rehabilitation and Physical Medicine Unit, Universite Catholique de Louvain, Unite de Readaptation, Tour Pasteur 5375, Avenue Mounier 53, 1200, Brussels, Belgium
    Eur Spine J 19:1179-88. 2010
    ..The use of anterior spinal fusion (ASF) instead of the classic posterior fusion (PSF) may preserve more distal spinal levels in attempt to limit the ..
  30. pmc Mapping the interactions between Lys48 and Lys63-linked di-ubiquitins and a ubiquitin-interacting motif of S5a
    Aydin Haririnia
    Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA
    J Mol Biol 368:753-66. 2007
    ..Here we use NMR to study the interaction of a ubiquitin-interacting motif (UIM) of the proteasomal subunit S5a with di-ubiquitin, the simplest model for polyubiquitin chain, to gain insights into the mechanism of polyubiquitin ..
  31. ncbi Glutathione reduces the toxicity associated with antitumor therapy of ascites fluid adsorbed over Staphylococcus aureus Cowan I in tumor bearing mice
    A S Verma
    Industrial Toxicology Research Centre, Lucknow, India
    Toxicol Lett 106:119-27. 1999
    ..p.) on alternate days for 15 days with adsorbed ascites fluid (ad-ASF) (0.1 ml) and glutathione (GSH) (250 mg/kg body weight) separately...
  32. ncbi Visual, long-latency auditory and brainstem auditory evoked potentials in migraine: relation to pattern size, stimulus intensity, sound and light discomfort thresholds and pre-attack state
    T Sand
    Department of Clinical Neurosciences, Trondheim University Hospital, Norwegian University of Science and Technology
    Cephalalgia 20:804-20. 2000
    ..30, P = 0.05). VEP an AEP amplitudes, habituation, and amplitude-intensity function (ASF) slopes did not differ between groups when ANOVA main factors were considered...
  33. doi The role of Amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis
    George H Thompson
    Division of Pediatric Orthopaedics, Rainbow Babies and Children s Hospital, University Hospital Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Spine (Phila Pa 1976) 33:2237-42. 2008
    ..A retrospective study of the effectiveness of Amicar (epsilon aminocaproic acid)...
  34. pmc Exonic splicing enhancer-dependent selection of the bovine papillomavirus type 1 nucleotide 3225 3' splice site can be rescued in a cell lacking splicing factor ASF/SF2 through activation of the phosphatidylinositol 3-kinase/Akt pathway
    Xuefeng Liu
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:2105-15. 2003
    ..Two exonic splicing enhancers, each containing two ASF/SF2 (alternative splicing factor/splicing factor 2) binding sites, are located between the two 3' splice sites and ..
  35. doi Poly(ADP-ribose) binds to the splicing factor ASF/SF2 and regulates its phosphorylation by DNA topoisomerase I
    Maria Malanga
    Department of Structural and Functional Biology, University Federico II, Via Cinthia, Monte S Angelo, Naples, Italy
    J Biol Chem 283:19991-8. 2008
    ..We found that, in the presence of both DNA and the alternative splicing factor/splicing factor 2 (ASF/SF2, a prototypical SR-protein), poly(ADP-ribose) affected topoisomerase I substrate selection and gradually ..
  36. ncbi hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B
    Alain Expert-Bezançon
    Centre de Genetique Moleculaire, CNRS UPR 2167, Laboratoire propre associe a l Universite Pierre et Marie Curie, 91198 Gif sur Yvette, France
    J Biol Chem 279:38249-59. 2004
    ..RNA affinity chromatography, we identified heterogeneous nuclear ribonucleoprotein (hnRNP) A1, the SR proteins ASF/SF2 and SC35, and hnRNP F/H as specific components that are assembled onto the G-rich element...
  37. ncbi A highly sensitive and specific gel-based multiplex RT-PCR assay for the simultaneous and differential diagnosis of African swine fever and Classical swine fever in clinical samples
    Montserrat Agüero
    Laboratorio Central Veterinario, Ministerio de Agricultura, Pesca y Alimentación, Algete, 28110 Madrid, Spain
    Vet Res 35:551-63. 2004
    ..start multiplex RT-PCR assay is presented for the simultaneous and differential diagnosis of African swine fever (ASF) and Classical swine fever (CSF)...
  38. ncbi Metastable Se6 as a ligand for Ag+: from isolated molecular to polymeric 1D and 2D structures
    Damian Aris
    Department of Chemistry, University of New Brunswick, Fredericton N B, E3B 6E2, Canada
    Dalton Trans 40:5865-80. 2011
    ..selenium led to crystals of 1/∞{[Ag(Se(6))](∞)[Ag(2)(SbF(6))(3)](∞)} 3 and {1/∞[Ag(Se(6))Ag](∞)}[AsF(6)](2)4. Pure bulk 4 was best prepared by the reaction of Se(4)[AsF(6)](2), silver metal and elemental selenium...
  39. ncbi Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1
    H Fu
    Cellular and Molecular Biology Program, University of Wisconsin Madison 53706, USA
    J Biol Chem 273:1970-81. 1998
    ..We have identified previously a candidate for one such receptor from diverse species, designated here as Mcb1 for Multiubiquitin chain-binding protein, based on its ability to bind Lys48-linked multiubiquitin chains and its ..
  40. ncbi Molecular monitoring of African swine fever virus using surveys targeted at adult ornithodoros ticks: a re-evaluation of Mkuze game reserve, South Africa
    L F Arnot
    Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0002 South Africa
    Onderstepoort J Vet Res 76:385-92. 2009
    The Mkuze Game Reserve (MGR), in north-eastern KwaZulu-Natal Province, South Africa is an African swine fever virus (ASF) controlled area...
  41. pmc Entamoeba invadens: the requirement for galactose ligands during encystment
    N A Turner
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
    Exp Parasitol 116:467-74. 2007
    ..The role of serum components (and the gal-terminated ligand asialofetuin; ASF) adsorbed onto the surface upon which encystment proceeds, and their effect on the multi-cellular aggregation ..
  42. pmc Identification and characterization of a Drosophila proteasome regulatory network
    Josefin Lundgren
    Department of Molecular Biology and Functional Genomics, Stockholm University, S 106 91 Stockholm, Sweden
    Mol Cell Biol 25:4662-75. 2005
    ..in Drosophila melanogaster cell lines, RNA interference (RNAi)-mediated inhibition of the 26S proteasome subunit Rpn10/S5a and suppression of proteasome activity through treatment with active-site inhibitors...
  43. pmc Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activity
    Abhishek Chandra
    Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Curr Genet 56:543-57. 2010
    ..Multiubiquitinated proteins interact with proteasome receptors, such as Rpn10, which intriguingly is also required for promoting proteasome stability...
  44. ncbi Co-circulation of two genetically distinct viruses in an outbreak of African swine fever in Mozambique: no evidence for individual co-infection
    A D S Bastos
    Department of Zoology and Entomology, Mammal Research Institute, University of Pretoria, Pretoria 0002, South Africa
    Vet Microbiol 103:169-82. 2004
    ..first 3 weeks of quarantine of what appeared clinically and on post mortem examination to be African swine fever (ASF)...
  45. doi Intensity dependence of auditory evoked potentials during light interference in migraine
    Anna Ambrosini
    Headache Clinic, IRCCS INM Neuromed, Via Atinense, 18, I 86077 Pozzilli, Isernia, Italy
    Neurosci Lett 492:80-3. 2011
    ..IDAP was measured as the amplitude/stimulus intensity function (ASF) slope...
  46. pmc Structural, functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers
    Z M Zheng
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    J Virol 71:9096-107. 1997
    ..Substitution of U residues for either A or G residues in and around potential ASF/SF2 binding sites in SE1 or SE2 resulted in a significant reduction of splicing enhancer activity...
  47. pmc African swine fever virus isolate, Georgia, 2007
    Rebecca J Rowlands
    Institute for Animal Health, Pirbright, UK
    Emerg Infect Dis 14:1870-4. 2008
    African swine fever (ASF) is widespread in Africa but is rarely introduced to other continents. In June 2007, ASF was confirmed in the Caucasus region of Georgia, and it has since spread to neighboring countries...
  48. doi Nanoemulsions of an anti-oxidant synergy formulation containing gamma tocopherol have enhanced bioavailability and anti-inflammatory properties
    Fonghsu Kuo
    Biomedical Engineering and Biotechnology Ph D Program, Center for Health and Disease Research, Division of NanoMedicine, University of Massachusetts Lowell, Lowell, MA 01854, USA
    Int J Pharm 363:206-13. 2008
    ..study investigated whether MicroFluidizer Processor-based nanoemulsions of an antioxidant synergy formulation (ASF), containing delta, alpha and gamma tocopherol influenced inflammation and bioavailability in CD-1 mice...
  49. ncbi Systematic analysis of longitudinal serological responses of pigs infected experimentally with African swine fever virus
    Ana Luísa Reis
    Instituto Gulbenkian de Ciencia, Apartado 14, 2781 901 Oeiras, Portugal
    J Gen Virol 88:2426-34. 2007
    ..In this study, the role of antibodies in the pathogenicity and diagnosis of African swine fever (ASF) was explored...
  50. ncbi Experiences of an OIE Collaborating Centre in molecular diagnosis of transboundary animal diseases: a review
    S Belak
    Joint Research and Development Division of the National Veterinary Institute, OIE Collaborating Centre for the Application of Polymerase Chain Reaction Methods for Diagnosis of Viral Diseases in Veterinary Medicine, Uppsala, Sweden
    Dev Biol (Basel) 128:103-12. 2007
    ..g., foot-and-mouth disease (FMD), classical swine fever (CSF), African swine fever (ASF) and highly pathogenic avian influenza (HPAI) are regularly occurring and re-occurring on various continents, ..
  51. doi Anterior spinal fusion versus posterior spinal fusion for moderate lumbar/thoracolumbar adolescent idiopathic scoliosis: a prospective study
    Yipeng Wang
    Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
    Spine (Phila Pa 1976) 33:2166-72. 2008
    ..A prospective study...
  52. ncbi A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume
    Randy L Buckner
    Department of Psychology, HHMI at Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neuroimage 23:724-38. 2004
    ..Automated atlas transformation generated the Atlas Scaling Factor (ASF) defined as the volume-scaling factor required to match each individual to the atlas target...
  53. doi Total extract and standardized fraction from the stem bark of Butea monosperma have osteoprotective action: evidence for the nonestrogenic osteogenic effect of the standardized fraction
    Rashmi Pandey
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Menopause 17:602-10. 2010
    ..of this study was to determine the skeletal effects of Butea total extract (BTE) and its acetone soluble fraction (ASF) from Butea monosperma, which is rich in methoxyisoflavones, in ovariectomized (OVx) rats, a model for ..
  54. ncbi Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing
    Laura K Zerbe
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 802262, USA
    Mol Carcinog 41:187-96. 2004
    ..Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 and alternative splicing factor/splicing factor 2 (ASF/SF2) act antagonistically to modulate splice site selection...
  55. doi Developmental-stage-specific regulation of the polyubiquitin receptors in Drosophila melanogaster
    Zoltán Lipinszki
    Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary
    J Cell Sci 122:3083-92. 2009
    ..The stoichiometry of the proteasomal p54/Rpn10 polyubiquitin receptor subunit, relative to that of other regulatory particle (RP) subunits falls suddenly at the ..
  56. ncbi One-step and two-step spin-crossover iron(II) complexes of ((2-methylimidazol-4-yl)methylidene)histamine
    Tetsuya Sato
    Department of Chemistry, Faculty of Science, Kumamoto University, Kurokami 2 39 1, Kumamoto 860 8555, Japan
    Inorg Chem 48:7211-29. 2009
    ..solvent = 2-PrOH and CH(3)CN) and [Fe(H(2)L(2-Me))(2)]X x Y x solvent (X = Cl and Br; Y = ClO(4), BF(4), PF(6), and AsF(6); solvent = EtOH and 2-PrOH)...
  57. pmc Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1
    Nanette Rooke
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 1602 Molecular Sciences Building, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
    Mol Cell Biol 23:1874-84. 2003
    ..Proteins binding to this element were identified as hnRNP A1, hnRNP H, hnRNP F, and SF2/ASF by site-specific cross-linking and immunoprecipitation...
  58. ncbi Purification of poly-ubiquitinated proteins by S5a-affinity chromatography
    R Layfield
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Proteomics 1:773-7. 2001
    ..The S5a subunit of the 26S proteasome binds poly-ubiquitin chains containing four or more ubiquitins...
  59. ncbi The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 26:220-7. 2002
    ....
  60. ncbi Xe3OF3(+), a precursor to a noble-gas nitrate; syntheses and structural characterizations of FXeONO2, XeF2·HNO3, and XeF2·N2O4
    Matthew D Moran
    Department of Chemistry, McMaster University, Hamilton, Ontario L8S 4M1, Canada
    J Am Chem Soc 132:13823-39. 2010
    Xenon fluoride nitrate has been synthesized by reaction of NO(2)F with [FXeOXeFXeF][AsF(6)] at -50 °C...
  61. ncbi A novel Physarum polycephalum SR protein kinase specifically phosphorylates the RS domain of the human SR protein, ASF/SF2
    Shide Liu
    Shenzhen Key Laboratory of Microbial and Genetic Engineering, College of Life Science Shenzhen University, Shenzhen, China
    Acta Biochim Biophys Sin (Shanghai) 41:657-67. 2009
    ..vitro phosphorylation assay to investigate the phosphorylation effect of recombinant PSRPK on the human SR protein, ASF/SF2. Western blot analysis showed that PSRPK could phosphorylate ASF/SF2 in E. coli cells...
  62. doi Molecular characterisation of African swine fever viruses from Nigeria (2003-2006) recovers multiple virus variants and reaffirms CVR epidemiological utility
    Olajide A Owolodun
    Department of Biochemistry and AMB, National Veterinary Research Institute, Vom, Plateau State, Nigeria
    Virus Genes 41:361-8. 2010
    ..from wild and domestic suids in Nigeria, over a 3-year period (2003-2006), were evaluated for African swine fever (ASF) virus genome presence by targeting three discrete genome regions, namely the 478-bp C-terminal p72 gene region ..
  63. ncbi Pig major acute-phase protein and apolipoprotein A-I responses correlate with the clinical course of experimentally induced African Swine Fever and Aujeszky's disease
    Rakel Carpintero
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    Vet Res 38:741-53. 2007
    ..The animals were experimentally infected with African Swine Fever (ASF) or Aujeszky's disease (AD) viruses...
  64. pmc Regulation of human neurotropic JC virus replication by alternative splicing factor SF2/ASF in glial cells
    Ilker Kudret Sariyer
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e14630. 2011
    ....
  65. ncbi The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation
    Felicie F Andersen
    Department of Molecular and Structural Biology, University of Aarhus, C F Møllers Alle, Denmark
    J Mol Biol 322:677-86. 2002
    Human topoisomerase I interacts with and phosphorylates the SR-family of RNA splicing factors, including ASF/SF2, and has been suggested to play an important role in the regulation of RNA splicing...
  66. ncbi Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a
    Kyoung Seok Ryu
    Yusong gu, Gusong Dong 373 1, Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejon 305 701, South Korea
    J Biol Chem 278:36621-7. 2003
    ..On the other hand, the UbL domain interacts with the poly-Ub binding site 2 (PUbS2) domain of the S5a protein, which can carry polyubiquitinated substrates into the proteasome...
  67. ncbi Expression of alphasmooth muscle actin in lens epithelia from human donors and cataract patients
    Elisabeth Rungger-Brandle
    Cell Biology Laboratory, University Eye Clinic, 22, Rue Alcide Jentzer, CH 1211 Geneve, Switzerland
    Exp Eye Res 81:539-50. 2005
    ..cataract (CAT), and cataractous lenses with posterior subcapsular opacities (PSO) or anterior subcapsular fibrosis (ASF)...
  68. ncbi Wax-matrix tablet for time-dependent colon-specific delivery system of sophora flavescens Aiton: preparation and in vivo evaluation
    Meijuan Zou
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P R China
    Drug Dev Ind Pharm 35:224-33. 2009
    ..expanding agent, carboxymethyl starch sodium (CMS-Na), and NaCl was prepared, and Sophora flavescens Aiton (ASF, extracts of traditional Chinese medicine) was used as model drug...
  69. pmc HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing
    D M Powell
    Gladstone Institute of Virology and Immunology, University of California, San Francisco 94141 9100, USA
    Proc Natl Acad Sci U S A 94:973-8. 1997
    ..Our studies now demonstrate that at least one member of the SR family of splicing factors, SF2/ASF, specifically binds to a subregion of the RRE in vitro in a Rev-dependent manner...
  70. doi Bone morphogenetic protein (RhBMP-2) as a substitute for iliac crest bone graft in multilevel adult spinal deformity surgery: minimum two-year evaluation of fusion
    Daniel S Mulconrey
    Department of Orthopaedic Surgery, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, Missouri, USA
    Spine (Phila Pa 1976) 33:2153-9. 2008
    ..Prospective, single center, nonblinded radiographic analysis of anterior and posterior adult spinal deformity fusions performed with bone morphogenetic protein (rhBMP-2)...
  71. ncbi The A-site finger in 23 S rRNA acts as a functional attenuator for translocation
    Taeko Komoda
    Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    J Biol Chem 281:32303-9. 2006
    Helix 38 (H38) in 23 S rRNA, which is known as the "A-site finger (ASF)," is located in the intersubunit space of the ribosomal 50 S subunit and, together with protein S13 in the 30 S subunit, it forms bridge B1a...
  72. ncbi The effects of exercise training on abdominal visceral fat, body composition, and indicators of the metabolic syndrome in postmenopausal women with and without estrogen replacement therapy: the HERITAGE family study
    John S Green
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77845, USA
    Metabolism 53:1192-6. 2004
    ..tomography (CT) scans were used to assess AVF as well as total abdominal fat (TAF) and abdominal subcutaneous fat (ASF)...
  73. doi Angiocidin induces differentiation of acute myeloid leukemia cells
    George P Tuszynski
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, United States Electronic address
    Exp Mol Pathol 95:249-54. 2013
    ..We previously reported that the novel angiogenic inhibitor, angiocidin, induces differentiation of monocytes to macrophages...
  74. ncbi An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers
    Philip J Smith
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Hum Mol Genet 15:2490-508. 2006
    ..out a refined functional SELEX screen for motifs that can act as ESEs in response to the human SR protein SF2/ASF. The test BRCA1 exon under selection was internal, rather than the 3'-terminal IGHM exon used in our earlier ..
  75. ncbi Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation
    Jonathan H Siekmann
    Program in International Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 133:3972S-3980S. 2003
    Animal source foods (ASF) can provide micronutrients in greater amounts and more bioavailable forms compared to plant source foods, but their intake is low in many poor populations...
  76. ncbi Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidation
    Chung Yen Chen
    Antioxidants Research Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University
    J Nutr 135:1366-73. 2005
    ..Almond skin flavonoids (ASF) were extracted with HCl:H2O:methanol (1:19:80) and their content of catechins and flavonols identified by HPLC ..
  77. pmc On the Differential Diagnosis of Anxious from Nonanxious Major Depression by means of the Hamilton Scales
    George Konstantakopoulos
    First Department of Psychiatry, Athens University Medical School, Eginition Hospital, 11528 Athens, Greece Section of Cognitive Neuropsychiatry, Department of Psychosis Studies, Institute of Psychiatry, King s College London, London SE58AF, UK
    ScientificWorldJournal 2013:294516. 2013
    ..diagnosed from nonanxious MDD (NA-MDD) as MDD with a cut-off score ≥7 on the HAM-D anxiety-somatization factor (ASF). We investigated whether additional HAM-D items discriminate A-MDD from NA-MDD...
  78. ncbi Comparison and characteristics of the formation of different adipose tissues in ducks during early growth
    J Kou
    Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya an, People s Republic of China
    Poult Sci 91:2588-97. 2012
    ..in 5 regions of subcutaneous tissue, including the neck area (NSF), chest area (CSF), lower abdomen area (ASF), back area (BSF), and leg area (LSF), were analyzed by comparing the morphology of the sections, adipocyte volume ..
  79. pmc Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription
    Vaishali R Moulton
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:1845-50. 2013
    ..We recently showed that the serine arginine protein splicing factor 2/alternative splicing factor (SF2/ASF) enhances the expression of CD3ζ chain by limiting the production of an unstable splice variant...
  80. doi Stochastic spatio-temporal modelling of African swine fever spread in the European Union during the high risk period
    Annette Nigsch
    Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA, United Kingdom
    Prev Vet Med 108:262-75. 2013
    African swine fever (ASF) is a notifiable viral pig disease with high mortality and serious socio-economic consequences...
  81. pmc A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43
    Xinli Li
    Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, Honolulu, Hawaii 96813, USA
    J Biol Chem 283:5748-59. 2008
    ..Interestingly, the UbL domain interacts with the S2/RPN1 and S5a/RPN10 protein subunits of the regulatory 19 S proteasome cap subunit of the 26 S proteasome complex...
  82. doi 285 generation of canine induced pluripotent stem cells from canine fetal fibroblast and adult fibroblast of cloned dog
    H S Kwon
    Seoul National University, Seoul, Korea
    Reprod Fertil Dev 25:290. 2012
    ..We isolated canine fetal fibroblast (FF) from normal beagles and adult skin fibroblast (ASF) from cloned beagles...
  83. pmc Risk of African swine fever introduction into the European Union through transport-associated routes: returning trucks and waste from international ships and planes
    Lina Mur
    VISAVET Center and Animal Health Department, Veterinary School, Complutense University of Madrid, Avenida Puerta de Hierro s n, 28040, Madrid, Spain
    BMC Vet Res 8:149. 2012
    The uncontrolled presence of African swine fever (ASF) in Russian Federation (RF) poses a serious risk to the whole European Union (EU) pig industry...
  84. pmc Subcomplexes of PA700, the 19 S regulator of the 26 S proteasome, reveal relative roles of AAA subunits in 26 S proteasome assembly and activation and ATPase activity
    David Thompson
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    J Biol Chem 284:24891-903. 2009
    ..Our results reveal relative structural and functional relationships among the AAA subunits of PA700 and new insights about mechanisms of 26 S proteasome assembly and activation...
  85. pmc Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates
    Minglian Zhao
    Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 285:4771-80. 2010
    ....
  86. ncbi Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains
    Han Seok Ko
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    FEBS Lett 566:110-4. 2004
    ....
  87. ncbi Diverse polyubiquitin interaction properties of ubiquitin-associated domains
    Shahri Raasi
    Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Nat Struct Mol Biol 12:708-14. 2005
    ..Conversely, non-UBA sequences can modulate the interaction properties of a UBA domain...
  88. doi Formation of nondegradable forked ubiquitin conjugates by ring-finger ligases and its prevention by S5a
    Hyoung Tae Kim
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 832:639-52. 2012
    ..that protect against the generation of such nondegradable Ub conjugates, we discovered that the presence of S5a (Rpn10) or a GST-fusion of S5a's UIM domains in a ubiquitination reaction led to the formation of conjugates that were ..
  89. doi FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis
    Neha Rani
    Division of Immunology, Department of Biology, University of Constance, 78457 Konstanz, Germany
    Nat Commun 3:749. 2012
    ..We identify the 26S proteasome subunit hRpn10/S5a as the receptor for FAT10, whereas NUB1L can bind to both Rpn10 and Rpn1/S2. Unexpectedly, FAT10 and NUB1L both interact with hRpn10 via the VWA domain...
  90. pmc African swine fever: how can global spread be prevented?
    Solenne Costard
    The Royal Veterinary College, Hatfield, Hertfordshire AL9 7TA, UK
    Philos Trans R Soc Lond B Biol Sci 364:2683-96. 2009
    African swine fever (ASF) is a devastating haemorrhagic fever of pigs with mortality rates approaching 100 per cent. It causes major economic losses, threatens food security and limits pig production in affected countries...
  91. pmc The splicing-factor oncoprotein SF2/ASF activates mTORC1
    Rotem Karni
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 105:15323-7. 2008
    The splicing factor SF2/ASF is an oncoprotein that is up-regulated in many cancers and can transform immortal rodent fibroblasts when slightly overexpressed...
  92. doi Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis
    Antony S Fatimababy
    Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan
    FEBS J 277:796-816. 2010
    ..of ubiquitin/26S proteasome-mediated proteolysis (UPP), which is mediated directly by the proteasome subunit RPN10 and/or RPN13, or indirectly by ubiquitin receptors containing ubiquitin-like and ubiquitin-associated domains...
  93. ncbi Multiple activities of the human splicing factor ASF
    J E Harper
    Department of Biological Sciences, Columbia University, New York, New York
    Gene Expr 2:19-29. 1992
    The effects of human alternative splicing factor, ASF, on in vitro splicing of adenovirus E1A pre-mRNA were examined...
  94. pmc Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1
    Chen Ting Ma
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093 0636, USA
    J Mol Biol 403:386-404. 2010
    ..kinase SRPK1 has been shown to polyphosphorylate the N-terminal portion of the RS domain (RS1) of the SR protein ASF/SF2, a modification that promotes nuclear entry of this splicing factor and engagement in splicing function...
  95. ncbi X-ray crystal structures of [XeF][MF6] (M = As, Sb, Bi), [XeF][M2F11] (M = Sb, Bi) and estimated thermochemical data and predicted stabilities for noble-gas fluorocation salts using volume-based thermodynamics
    Hugh St A Elliott
    Department of Chemistry, McMaster University, Hamilton, Ontario, L8S 4M1, Canada
    Inorg Chem 49:8504-23. 2010
    ..XeF][BiF(6)], and [XeF][Bi(2)F(11)], have been determined for the first time, and those of XeF(2), [XeF][AsF(6)], [XeF][Sb(2)F(11)], and [XeF(3)][Sb(2)F(11)] have been redetermined with greater precision at -173 °C...
  96. doi An assessment of parathyroid hormone, calcitonin, 1,25 (OH)2 vitamin D3, estradiol and testosterone in men with active calcium stone disease and evaluation of its biochemical risk factors
    Nasser Shakhssalim
    Shahid Labbafinejad Medical Center, Shahid Beheshti University, M C, No 103, Boostan 9th St, Pasdaran Ave, P O Box 1666677951, Tehran, IR Iran
    Urol Res 39:1-7. 2011
    ..Male active renal calcium stone formers (ASF) were enrolled from December 2008 to April 2009. Controls were selected from age and sex matched individuals...
  97. doi Comparison of surgical treatment in Lenke 5C adolescent idiopathic scoliosis: anterior dual rod versus posterior pedicle fixation surgery: a comparison of two practices
    Matthew J Geck
    Department of Orthopaedics, Spine Austin, 3001 Beecaves Road, Austin, TX 78746, USA
    Spine (Phila Pa 1976) 34:1942-51. 2009
    ..Multicenter analysis of 2 groups of patients surgically treated for Lenke 5C adolescent idiopathic scoliosis (AIS)...
  98. doi Lumbar spinal fusion versus anterior lumbar disc replacement: the financial implications
    Vikas V Patel
    Spine Center, University of Colorado Health Sciences, Denver, CO 80045, USA
    J Spinal Disord Tech 21:473-6. 2008
    ..Cost-identification analysis with retrospective and calculated cost...
  99. pmc Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF
    Jeremy R Sanford
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    PLoS ONE 3:e3369. 2008
    The serine and arginine-rich protein family (SR proteins) are highly conserved regulators of pre-mRNA splicing. SF2/ASF, a prototype member of the SR protein family, is a multifunctional RNA binding protein with roles in pre-mRNA ..
  100. pmc The interaction of angiocidin with tissue transglutaminase
    Darryl Z L'Heureux
    Temple University, Department of Neuroscience, Center for Neurovirology, MERB 7th Floor, 3500 N Broad Street, Philadelphia, PA 19140, USA
    Exp Mol Pathol 88:15-25. 2010
    b>Angiocidin, a matrix bound and tumor associated protein, has been shown to inhibit tumor progression and angiogenesis. We previously demonstrated that angiocidin binds to thrombospondin-1 and alpha2beta1 integrin...
  101. pmc Cyclic AMP-dependent protein kinase A regulates the alternative splicing of CaMKIIδ
    Qingqing Gu
    Department of Cardiology, The Affiliated Hospital of Nantong University, Nantong, Jiangsu, People s Republic of China
    PLoS ONE 6:e25745. 2011
    ..the alternative splicing of exons 14, 15, and 16 of its pre-mRNA, which is regulated by the splicing factor SF2/ASF. Inclusion of exons 15 and 16 or of exon 14 generates δA or δB isoform...

Research Grants78

  1. OXYGEN RADICAL TOXICITY AND PROTEIN DEGRADATION
    Kelvin Davies; Fiscal Year: 2005
    ..To further test ubiquitinylation of oxidized proteins, we will use glutathione-sepharose immobilized- S5a (S5a is a 26s proteasome subunit, which binds multiubiquitinylated proteins), and add S5a to cell extracts to ..
  2. BIOCHEMISTRY OF PRE-MRNA SPLICING
    ADRIAN KRAINER; Fiscal Year: 2009
    ..For example, the gene encoding the splicing factor SF2/ASF is a proto-oncogene that can be activated by gene amplification in breast cancer...
  3. BIOCHEMISTRY OF PRE-MRNA SPLICING
    ADRIAN KRAINER; Fiscal Year: 2007
    ..For example, the gene encoding the splicing factor SF2/ASF is a proto-oncogene that can be activated by gene amplification in breast cancer...
  4. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..For example, the gene encoding the splicing factor SF2/ASF is a proto-oncogene that can be activated by gene amplification in breast cancer...
  5. Splicing factors as therapeutic targets for the treatment of ovarian cancer
    WILLIAM BECK; Fiscal Year: 2009
    ..Indeed, several splicing factors, including PTB and SRp20, are overexpressed in tumors and one, SF2/ASF, was shown to be an oncogene...
  6. Splicing factors as therapeutic targets for the treatment of ovarian cancer
    William T Beck; Fiscal Year: 2010
    ..Indeed, several splicing factors, including PTB and SRp20, are overexpressed in tumors and one, SF2/ASF, was shown to be an oncogene...
  7. Role of p300/CBP and hHR23 Proteins in p53 Regulation
    Steven R Grossman; Fiscal Year: 2010
    ..hHR23 proteins, in turn, are recognized by the S5a subunit of the proteasome, which may be the gateway to the proteasome for p53, leading to its destruction...
  8. Sphingolipid Regulation of Caspase 9 Alternative Splicing
    Charles Chalfant; Fiscal Year: 2009
    ..laboratory disclose that the alternative splicing of caspase 9 is intrinsically linked to the SR protein, SRp30a (ASF/SF2)...
  9. Sphingolipid Regulation of Caspase 9 Alternative Splicing
    Charles Chalfant; Fiscal Year: 2007
    ..laboratory disclose that the alternative splicing of caspase 9 is intrinsically linked to the SR protein, SRp30a (ASF/SF2)...
  10. Rare disease CRC for new therapies and new diagnostics
    Arthur Beaudet; Fiscal Year: 2006
    ..have active affiliation with the International Rett Syndrome Association (IRSA), the Angelman Syndrome Foundation (ASF), and the Prader-Willi Syndrome Association (PWSA). A website for this RDCRC is available at www.imgen.bcm.tmc...
  11. SYSTEMATIC ANALYSIS OF PROTEOLYSIS PATHWAYS FOR CULLIN TARGETS
    JEFFREY WADE HARPER; Fiscal Year: 2010
    ..Using the Global Protein Stability (GPS) system, we will identify targets of the proteasome-associated Rpn10 "facilitator" protein from a library of cells expressing 12,000 human genes, thereby defining the repertoire of ..
  12. SYSTEMATIC ANALYSIS OF PROTEOLYSIS PATHWAYS FOR CULLIN TARGETS
    Jeffrey Harper; Fiscal Year: 2009
    ..Using the Global Protein Stability (GPS) system, we will identify targets of the proteasome-associated Rpn10 "facilitator" protein from a library of cells expressing 12,000 human genes, thereby defining the repertoire of ..
  13. NMR Structural Studies of Ubiquitin Receptor Protein Complexes
    Kylie J Walters; Fiscal Year: 2010
    ..to their degradation, as their initial interaction with the proteasome is through RP ubiquitin receptors, S5a and Rpn13...
  14. Mechanisms of alternative splicing of pre-mRNA
    James Manley; Fiscal Year: 2007
    ..The following specific aims are proposed. 1. Novel functions of ASF/SF2...
  15. Mechanisms of alternative splicing of pre-mRNA
    James Manley; Fiscal Year: 2009
    ..The following specific aims are proposed. 1. Novel functions of ASF/SF2...
  16. REGULATION OF ALTERNATIVE PROCESSING OF CALCITONIN/CGRP
    Susan Berget; Fiscal Year: 2002
    ..that the enhancer has a CORE resembling a pseudo exon and binds splicing factors, including U1 snRNPs, SR proteins (ASF/SF2 and SRp20), and PTB...
  17. Role of protein phosphorylation in RNA splicing
    Joseph Adams; Fiscal Year: 2007
    ..The goals of this proposal will include the identification of the serine phosphorylation sites in the SR protein ASF/SF2, a substrate for human SRPK1...
  18. Molecular Mechanisms that Cause Muscle Atrophy
    Alfred L Goldberg; Fiscal Year: 2010
    ..We have identified new protein partners of MuRF1 (S5a and novel E2s) that enhance MuRF1- dependent proteolysis in vitro and protein substrates (including critical ..
  19. Nanospheres as Vehicles for Treatment of Neuroblastoma
    Thomas Shea; Fiscal Year: 2004
    ..In our ongoing studies we have developed an anti-oxidant synergistic formulation ("ASF"), comprised of alpha-tocopherol (vitamin E), sodium pyruvate and phosphatidyl choline, that supports axonal ..
  20. FUNCTION & REGULATION OF THE HUMAN SPLICING FACTOR SC35
    Xiang Dong Fu; Fiscal Year: 2002
    ..Two SR proteins, SC35 and SF2/ASF, which have been shown to specifically commit human IgM and HIV tat pre-mRNA to splicing, respectively, will be ..
  21. Mechanisms of alternative splicing of pre-mRNA
    James L Manley; Fiscal Year: 2010
    ..An ASF/SF2-CTD fusion protein has been used to show that the CTD can enhance splicing in vitro in the presence of a ..
  22. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2004
    ..The protein, termed angiocidin, inhibited endothelial cell viability and tube formation in vitro and prevented the growth of tumors in vivo...
  23. RR-03-011, Extramural Research Facilities Construction *
    Dallas Hyde; Fiscal Year: 2004
    ..The building will include 5,992 assignable square feet (ASF) of laboratory research space, 178 ASF of research support space and 1,200 ASF of office space...
  24. MOLECULAR CHAPERONES AND PROTEIN DEGRADATION
    Alfred Goldberg; Fiscal Year: 2007
    ..in ubiquitination by CHIP and to learn how additional factors, in particular, the ubiquitin-binding protein, S5a, may function to facilitate the degradation of the Ub-conjugated proteins by 26S proteasomes. In E...
  25. ASF/SF2: Phosphorylation and RNA Binding
    Gourisankar Ghosh; Fiscal Year: 2010
    Alternating splicing factor/splicing factor 2 (ASF/SF2), a member of the serine-arginine (SR) protein family, plays important roles both in constitutive and alternative pre-mRNA splicing...
  26. PROTEIN 4.1 GENE EXPRESSION IN DEVELOPING RED CELLS
    EDWARD BENZ; Fiscal Year: 2009
    ..in late erythroid cells and critical for the exon 16 splicing switch; 2) Demonstration that increased SF2/ASF expression in late erythroid cells stimulates exon 16 splicing by binding an exonic splicing enhancer; 3) ..
  27. PROTEIN 4.1 GENE EXPRESSION IN DEVELOPING RED CELLS
    Edward J Benz; Fiscal Year: 2010
    ..in late erythroid cells and critical for the exon 16 splicing switch;2) Demonstration that increased SF2/ASF expression in late erythroid cells stimulates exon 16 splicing by binding an exonic splicing enhancer;3) ..
  28. HUMAN CYTOMEGALOVIRUS TEGUMENT PROTEINS
    Thomas E Shenk; Fiscal Year: 2010
    ..it is required for efficient replication in epithelial cells, and we have shown that it binds to the cellular SF2/ASF protein, a multi-functional splicing factor...