PSMD2

Summary

Gene Symbol: PSMD2
Description: proteasome 26S subunit, non-ATPase 2
Alias: P97, RPN1, TRAP2, 26S proteasome non-ATPase regulatory subunit 2, 55.11 protein, TNFR-associated protein 2, proteasome (prosome, macropain) 26S subunit, non-ATPase, 2, protein 55.11, tumor necrosis factor type 1 receptor-associated protein 2
Species: human
Products:     PSMD2

Top Publications

  1. Liu X, Zhang Y, Piao J, Mao D, Li Y, Li W, et al. Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010-2012. Nutrients. 2017;9: pubmed publisher
    ..Reference values were calculated covering the central 95% reference intervals (P2.5-P97.5) after excluding outliers by Dixon's test. The overall reference values of serum trace elements were 131.5 (55...
  2. Brahms A, Mudhasani R, Pinkham C, Kota K, Nasar F, Zamani R, et al. Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway. J Virol. 2017;91: pubmed publisher
    ..b>p97/valosin-containing protein (VCP), which is involved in membrane remodeling in the secretory pathway and a known ..
  3. Wong H, Kumar P, Tay F, Moreau D, Liu D, Bard F. Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes. J Virol. 2015;89:11116-28 pubmed publisher
    ..In addition, our screen reveals an unexpected role for valosin-containing protein (VCP/p97) in early steps of infection...
  4. Wang N, Zhao J, He X, Sun H, Zhang G, Wu F. Comparative proteomic analysis of drought tolerance in the two contrasting Tibetan wild genotypes and cultivated genotype. BMC Genomics. 2015;16:432 pubmed publisher
    ..expressed or up-regulated under drought stress in XZ5 but not in XZ54, including melanoma-associated antigen p97, type I chlorophyll a/b-binding protein b, glutathione S-transferase 1, ribulosebisphosphate carboxylase large ..
  5. Stojsavljević A, Borković Mitić S, Vujotic L, Grujicic D, Gavrovic Jankulovic M, Manojlović D. The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population. Ecotoxicol Environ Saf. 2019;169:402-409 pubmed publisher
    ..5-P97.5). The obtained geometric mean (GM) for As, Cd, Pb, Th, and U were: 0.50 ng/g, 0.32 ng/g, 20.94 ng/g, 0...
  6. Jung K, Ko D, Shin N, Pyo C, Choi S. Endoplasmic reticulum-associated degradation potentiates the infectivity of influenza A virus by regulating the host redox state. Free Radic Biol Med. 2019;135:293-305 pubmed publisher
    ..The increase in SOD1 levels with the expression of siRNA-targeting p97, a central component of the ubiquitin-proteasome system, supports the major role of the ERAD process in IAV-..
  7. Jarocki V, Santos J, Tacchi J, Raymond B, Deutscher A, Jenkins C, et al. MHJ_0461 is a multifunctional leucine aminopeptidase on the surface of Mycoplasma hyopneumoniae. Open Biol. 2015;5:140175 pubmed publisher
    ..M. hyopneumoniae recruits plasmin(ogen) onto its cell surface via the P97 and P102 adhesins and the glutamyl aminopeptidase MHJ_0125...
  8. McFarlane M, MacDonald A, Stevenson A, Graham S. Human Papillomavirus 16 Oncoprotein Expression Is Controlled by the Cellular Splicing Factor SRSF2 (SC35). J Virol. 2015;89:5276-87 pubmed publisher
    ..SRSF2 did not affect transcription from the P97 promoter that controls viral oncoprotein expression...
  9. Wang F, Olson E, Shyng S. Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels. J Biol Chem. 2012;287:10482-93 pubmed publisher
    ..We show that both SUR1 and Kir6.2 form a complex with Derlin-1 and an associated AAA-ATPase, p97. Overexpression of Derlin-1 led to a decrease in the biogenesis efficiency and surface expression of K(ATP) ..

More Information

Publications133 found, 100 shown here

  1. Delabaere L, Orsi G, Sapey Triomphe L, Horard B, Couble P, Loppin B. The Spartan ortholog maternal haploid is required for paternal chromosome integrity in the Drosophila zygote. Curr Biol. 2014;24:2281-7 pubmed publisher
    ..Like Spartan, MH protein is involved in the resistance to UV radiation and recruits the p97/TER94 segregase to stalled DNA replication forks in somatic cells...
  2. Sugiyama H, Takahashi K, Yamamoto T, Iwasaki M, Narita M, Nakamura M, et al. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2017;114:340-345 pubmed publisher
    Novel APOBEC1 target 1 (Nat1) (also known as "p97," "Dap5," and "Eif4g2") is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (Eif4g1)...
  3. Maier M, Luks L, Baudendistel O, Wittmann V, Dietrich D. Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy. Chem Biol Interact. 2018;281:69-80 pubmed publisher
    ..HSP70 and DnaJ co-chaperones), proteases and proteasomal proteins (regulatory subunits of the 26S proteasome; Rpn1/2)...
  4. Cayli S, Ocakli S, Senel U, Eyerci N, Delibasi T. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. J Mol Histol. 2016;47:91-100 pubmed publisher
    ..Furthermore, Jab1/CSN5 expression was gradually upregulated and p97/VCP expression was downregulated in IR injury according to western blotting and immunohistochemistry...
  5. Volodin A, Kosti I, Goldberg A, Cohen S. Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization. Proc Natl Acad Sci U S A. 2017;114:E1375-E1384 pubmed publisher
    ..Down-regulation of PAX4 or its target gene encoding the p97/VCP ATPase reduced myofibril disassembly and degradation on denervation or fasting...
  6. Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, et al. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2015;112:E1135-42 pubmed publisher
    ..However, the p97 inhibitor eeyarestatin 1 enhanced immunotoxin killing...
  7. Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017;546:554-558 pubmed publisher
    ..of 69 human SCF (SKP1, CUL1, F-box protein) ubiquitin ligase complexes) binds IP3R3 and targets it for ubiquitin-, p97- and proteasome-mediated degradation to limit Ca2+ influx into mitochondria...
  8. Olmedo Carrillo P, Santiago Fernández P, Garcia Fuentes E, Ureña Fernández T, Gutiérrez Alcántara C, Sánchez Malo C, et al. Definition of reference ranges for free T4, TSH, and thyroglobulin levels in healthy subjects of the Jaén Health District. Endocrinol Diabetes Nutr. 2017;64:417-423 pubmed publisher
    ..59μg/L and 130.11μg/L respectively. Median TSH level was 1.83μIU/mL (p2.5=0.56μIU/mL, p97.5=4.66μIU/mL). Median FT4 level was 0.84ng/dL (p2.5=0.62ng/dL, p97.5=1.18ng/dL). TPO antibodies were detected in 5...
  9. Fu X, Adams Z, Liu R, Hepowit N, Wu Y, Bowmann C, et al. Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea. MBio. 2017;8: pubmed publisher
    ..protein remodeling, and oxidative stress and include the Ubl-modified MsrA, Orc3 (Orc1/Cdc6), and Cdc48d (Cdc48/p97 AAA+ ATPase)...
  10. Chai Y, Chae H, Kim K, Lee H, Choi S, Lee K, et al. Comparative Gene Expression Profiles in Parathyroid Adenoma and Normal Parathyroid Tissue. J Clin Med. 2019;8: pubmed publisher
    ..a densely connected sub-module, comprising eight hub molecules: SPCS2, RPL23, RPL26, RPN1, SEC11C, SEC11A, RPS25, and SEC61G...
  11. Han D, Di X, Fu Y, Mu T. Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. J Biol Chem. 2015;290:325-37 pubmed publisher
    ..Presumably, valosin-containing protein (VCP)/p97 extracts misfolded subunits from the endoplasmic reticulum membrane to the cytosolic proteasome for degradation...
  12. Langerak S, Kim M, Lamberg H, Godinez M, Main M, Winslow L, et al. The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle. Biol Open. 2018;7: pubmed publisher
    ..Daw or Myo in adult muscle tissues can be completely abrogated by knockdown of a 26S proteasome regulatory subunit Rpn1 in adult fly muscle, and that the prolonged lifespan caused by overexpression of Daw or Myo in adult muscle could ..
  13. Paliwal A, Temkin A, Kerkel K, Yale A, Yotova I, Drost N, et al. Comparative anatomy of chromosomal domains with imprinted and non-imprinted allele-specific DNA methylation. PLoS Genet. 2013;9:e1003622 pubmed publisher
    ..Two index regions (bisulfite PCR amplicons), one between the C3orf27 and RPN1 genes in chromosome band 3q21 and the other near the VTRNA2-1 vault RNA in band 5q31, proved to be new examples of ..
  14. Raymond B, Jenkins C, Seymour L, Tacchi J, Widjaja M, Jarocki V, et al. Proteolytic processing of the cilium adhesin MHJ_0194 (P123J ) in Mycoplasma hyopneumoniae generates a functionally diverse array of cleavage fragments that bind multiple host molecules. Cell Microbiol. 2015;17:425-44 pubmed publisher
    ..These extensive processing events are characterized here. The functional significance of the P97 cleavage fragments is also poorly understood...
  15. Okun J, Gan Schreier H, Ben Omran T, Schmidt K, Fang Hoffmann J, Gramer G, et al. Newborn Screening for Vitamin B6 Non-responsive Classical Homocystinuria: Systematical Evaluation of a Two-Tier Strategy. JIMD Rep. 2017;32:87-94 pubmed publisher
    ..In addition, dried blood spot samples selected by Met values >P97 in the newborn screening programs in Austria, Australia, the Netherlands, and Taiwan were analyzed for Hcy...
  16. Dos Santos L, Sreevatsan S, Torremorell M, Moreira M, Sibila M, Pieters M. Genotype distribution of Mycoplasma hyopneumoniae in swine herds from different geographical regions. Vet Microbiol. 2015;175:374-81 pubmed publisher
    ..The MLVA was standardized on the basis of the number of tandem repeats in two Mycoplasma adhesins, P97 and P146, which are proteins involved in the adherence of the pathogen to cilia...
  17. Tacchi J, Raymond B, Haynes P, Berry I, Widjaja M, Bogema D, et al. Post-translational processing targets functionally diverse proteins in Mycoplasma hyopneumoniae. Open Biol. 2016;6:150210 pubmed publisher
    ..The cell surface of M. hyopneumoniae is extensively modified by processing events that target the P97 and P102 adhesin families. Here, we present analyses of the proteome of M...
  18. Ugolino J, Fang S, Kubisch C, Monteiro M. Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death. Hum Mol Genet. 2011;20:3565-77 pubmed publisher
    ..knockdown of erasin, a platform for assembly of an ERAD complex, or expression of a dominant negative form of p97/VCP, a protein essential for dislocation of ERAD substrates, or inhibition of the proteasome all slowed degradation ..
  19. Ma X, Liu H, Li J, Wang Y, Ding Y, Shen H, et al. Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis. Nat Commun. 2017;8:1941 pubmed publisher
    ..results in a reduced level of CRL4CDT2-dependent Polη polyubiquitination at lysine 462, a delayed p97-dependent removal of Polη from replication forks, and significantly enhanced UV-induced mutagenesis even though ..
  20. Walworth K, Bodas M, Campbell R, Swanson D, Sharma A, Vij N. Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression. PLoS ONE. 2016;11:e0158507 pubmed publisher
    Elevated valosin containing protein (VCP/p97) levels promote the progression of non-small cell lung carcinoma (NSCLC)...
  21. Khodayari N, Wang R, Marek G, Krotova K, Kirst M, Liu C, et al. SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78. PLoS ONE. 2017;12:e0172983 pubmed publisher
    ..of ZAAT is influenced by modulation of gp78 E3 ligase and SVIP (small VCP-interacting protein) interaction with p97/VCP in ZAAT-expressing hepatocytes...
  22. Xu Y, Anderson D, Ye Y. The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation. Cell Discov. 2016;2:16040 pubmed
    ..proteins (referred to as unassembled soluble protein degradation, USPD) requires the ubiquitin selective chaperone p97, its co-factor nuclear protein localization protein 4 (Npl4), and the proteasome...
  23. Rodríguez Bautista Y, Correa Bautista J, González Jiménez E, Schmidt RioValle J, Ramírez Vélez R. [VALUES OF WAIST/HIP RATIO AMONG CHILDREN AND ADOLESCENTS FROM BOGOTÁ, COLOMBIA: THE FUPRECOL STUDY]. Nutr Hosp. 2015;32:2054-61 pubmed publisher
    ..Se calcularon los percentiles (P3, P10, P25, P50, P75, P90 y P97) según sexo y edad y se realizó una comparación entre los valores del ICC observados y los estándares ..
  24. Wiederstein J, Nolte H, Günther S, Piller T, Baraldo M, Kostin S, et al. Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep. 2018;23:1342-1356 pubmed publisher
    ..In addition, we demonstrate that METTL21C interacts with the ATPase p97 (VCP), which is mutated in various human MSP conditions...
  25. Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed publisher
    ..In this context, the ubiquitin-directed ATPase CDC-48/p97 recently emerged as a key regulator of chromatin-associated degradation in several of the DNA metabolic pathways ..
  26. Abaan O, Hendriks W, Uren A, Toretsky J, Erkizan H. Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1. Exp Cell Res. 2013;319:1-11 pubmed publisher
    ..One of these putative substrates was characterized as Valosin Containing Protein (VCP/p97). Using multiple biochemical assays we validated VCP as a novel substrate of PTPL1...
  27. Bastola P, Neums L, Schoenen F, Chien J. VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal. Mol Oncol. 2016;10:1559-1574 pubmed publisher
    Valosin-containing protein (VCP) or p97, a member of AAA-ATPase protein family, has been associated with various cellular functions including endoplasmic reticulum-associated degradation (ERAD), Golgi membrane reassembly, autophagy, DNA ..
  28. Liu Y, Ye Y. Roles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulum. Curr Protein Pept Sci. 2012;13:436-46 pubmed
    ..Intriguingly, many ERAD specific DUBs are physically associated with the retrotranslocation- driving ATPase p97. Here we discuss the potential functions of p97-associated DUBs including ataxin-3 and YOD1...
  29. Loayza D, Tam A, Schmidt W, Michaelis S. Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae. Mol Biol Cell. 1998;9:2767-84 pubmed
    ..suppressors of the mating defect of one of the ER-retained ste6 mutants has identified a proteasome subunit, Hrd2p/p97, previously implicated in the regulated degradation of wild-type hydroxymethylglutaryl-CoA reductase in the ER ..
  30. Kucej M, Fermaintt C, Yang K, Irizarry Caro R, Yan N. Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex. Cell Rep. 2017;18:2600-2607 pubmed publisher
    ..Phosphomimetic mutations of mitotic phosphorylation sites in TREX1 disrupted the interaction with the OST subunit RPN1. RNA-seq analysis of Trex1-/- mouse embryonic fibroblasts expressing TREX1 wild-type or phosphor-mutants ..
  31. Wang T, Jiang X, Chen G, Xu J. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Neurobiol Aging. 2015;36:527-35 pubmed publisher
    ..between FUS and proteins involved in neurodegenerative diseases and/or ubiquitin proteasome pathway, such as VCP/p97, PSF, UBA 1, and 26S proteosome non-ATPase regulatory subunit 12 (PSMD12/Rpn5)...
  32. Leichner G, Avner R, Harats D, Roitelman J. Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation. Mol Biol Cell. 2009;20:3330-41 pubmed publisher
    ..Dislocation of HMG(350)-HA and Insig-1-Myc requires metabolic energy and involves the AAA-ATPase p97/VCP...
  33. Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma Y, et al. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol Cell. 2017;67:322-333.e6 pubmed publisher
    ..5 Å resolution and determined seven distinct conformations of the Rpn1-p28-AAA subcomplex within the p28-bound RP at subnanometer resolutions...
  34. Tao S, Tillotson J, Wijeratne E, Xu Y, Kang M, Wu T, et al. Withaferin A Analogs That Target the AAA+ Chaperone p97. ACS Chem Biol. 2015;10:1916-1924 pubmed publisher
    ..We now show that WFA acts as an inhibitor of the chaperone, p97, both in vitro and in cell models in addition to inhibiting the proteasome in vitro...
  35. Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, et al. VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017;36:135-150 pubmed publisher
    ..Here, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy...
  36. Fedorova M, Vinokurova S, Pavlova L, Komel kov A, Korolenkova L, Kisseljov F, et al. Human papillomavirus types 16 E1 mRNA is transcribed from P14 early promoter in cervical neoplasms. Virology. 2016;488:196-201 pubmed publisher
    ..The amount of P14-initiated transcripts was significantly less compared to transcripts initiated from the major P97 HPV16 promoter in cervical intraepithelial neoplasms and squamous cell carcinomas...
  37. Rijal R, Arhzaouy K, Strucksberg K, Cross M, Hofmann A, Schroder R, et al. Mutant p97 exhibits species-specific changes of its ATPase activity and compromises the UBXD9-mediated monomerisation of p97 hexamers. Eur J Cell Biol. 2016;95:195-207 pubmed publisher
    b>p97 (VCP) is a homo-hexameric triple-A ATPase that exerts a plethora of cellular processes. Heterozygous missense mutations of p97 cause at least five human neurodegenerative disorders...
  38. Bhowmick S, Chakravarty C, Sellathamby S, Lal S. The influenza A virus matrix protein 2 undergoes retrograde transport from the endoplasmic reticulum into the cytoplasm and bypasses cytoplasmic proteasomal degradation. Arch Virol. 2017;162:919-929 pubmed publisher
    ..Further, M2 interacts with the endoplasmic-reticulum-resident AAA-ATPase p97 for its release into the cytoplasm...
  39. Barrera M, Aguilera S, Castro I, Cortes J, Bahamondes V, Quest A, et al. Pro-inflammatory cytokines enhance ERAD and ATF6? pathway activity in salivary glands of Sjögren's syndrome patients. J Autoimmun. 2016;75:68-81 pubmed publisher
    ..by generation of the ATF6f cleavage fragment, and increased expression of ERAD machinery components, such as EDEM1, p97, SEL1L, gp78, UBE2J1, UBE2G2, HERP and DERLIN1, were observed compared to controls...
  40. Morey T, Winick Ng W, Seah C, Rylett R. Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP. Front Mol Neurosci. 2017;10:415 pubmed publisher
    ..However, inhibition of the endoplasmic reticulum (ER)- and HSP-associated co-chaperone p97/VCP prevented degradation of ubiquitinated ChAT...
  41. Anderson D, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, et al. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 2015;28:653-665 pubmed publisher
    b>p97 is a AAA-ATPase with multiple cellular functions, one of which is critical regulation of protein homeostasis pathways. We describe the characterization of CB-5083, a potent, selective, and orally bioavailable inhibitor of p97...
  42. Barthelme D, Sauer R. Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine. J Mol Biol. 2016;428:1861-9 pubmed publisher
    The AAA+ Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-dependent cell signaling, degradation, and quality control pathways...
  43. Ménager J, Ebstein F, Oger R, Hulin P, Nedellec S, Duverger E, et al. Cross-presentation of synthetic long peptides by human dendritic cells: a process dependent on ERAD component p97/VCP but Not sec61 and/or Derlin-1. PLoS ONE. 2014;9:e89897 pubmed publisher
    ..Our data support a role for the ER-associated degradation machinery (ERAD)-related protein p97/VCP in the transport of SLP16-40 from early endosomes to the cytoplasm but formally exclude both sec61 and Derlin-1 ..
  44. Chen Z, Morales J, Guerrero P, Sun H, McCarty J. PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells. Cancer Res. 2018;78:3809-3822 pubmed publisher
    ..PTP-PEST balances GBM cell growth and invasion by interacting with the ATP-dependent ubiquitin segregase Vcp/p97 and regulating phosphorylation and stability of the focal adhesion protein p130Cas...
  45. Bayraktar O, Oral O, Kocaturk N, Akkoç Y, Eberhart K, Kosar A, et al. IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation. PLoS ONE. 2016;11:e0164864 pubmed publisher
    ..VCP/p97 was implicated in both pathways...
  46. Mountassif D, Fabre L, Zaid Y, Halawani D, Rouiller I. Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring. Biochem Biophys Res Commun. 2015;468:636-41 pubmed publisher
    Single amino acid mutations in valosin containing protein (VCP/p97), a highly conserved member of the ATPases associated with diverse cellular activities (AAA) family of ATPases has been linked to a severe degenerative disease affecting ..
  47. Arumughan A, Roske Y, Barth C, Forero L, Bravo Rodriguez K, Redel A, et al. Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun. 2016;7:13047 pubmed publisher
    ..report the generation of a quantitative interaction network, directly linking 14 human proteins to the AAA+ ATPase p97, an essential hexameric protein with multiple cellular functions...
  48. Cherok E, Xu S, Li S, Das S, Meltzer W, Zalzman M, et al. Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics. Mol Biol Cell. 2017;28:396-410 pubmed publisher
    ..Consistently, we find that Mff is an integral component of the MARCH5/p97/Npl4 complex, which is also controlled by MARCH5's C-terminal domain...
  49. Tao S, Liu P, Luo G, Rojo de la Vega M, Chen H, Wu T, et al. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex. Mol Cell Biol. 2017;37: pubmed publisher
    ..However, the path from the CUL3 complex to ultimate proteasomal degradation was previously unknown. p97 is a ubiquitin-targeted ATP-dependent segregase that extracts ubiquitylated client proteins from membranes, protein ..
  50. Bidkhori G, Narimani Z, Hosseini Ashtiani S, Moeini A, Nowzari Dalini A, Masoudi Nejad A. Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma. PLoS ONE. 2013;8:e67552 pubmed publisher
    ..In addition to the mentioned genes, there are some other genes (i.e. DLGAP5, BIRC5, PSMD2, Src, TTK, SENP2, PSMD2, DOK2, FUS and etc.) in the modules.
  51. Li S, Miao H, Cui X, Zhao Y, Wu Y. [Development of gas chromatography-mass spectrometry for determination of fatty acid esters of chloropropanols in milk powder and the pollution level of infant formula]. Zhonghua Yu Fang Yi Xue Za Zhi. 2015;49:554-9 pubmed
    ..the infant formula of the 6-month infant were used to estimate the dietary exposure assessment, and x (95% CI) and P97.5 of the contamination level of chloropropanols esters were used to represent the average dietary exposure and the ..
  52. Raman M, Sergeev M, Garnaas M, Lydeard J, Huttlin E, Goessling W, et al. Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Nat Cell Biol. 2015;17:1356-69 pubmed publisher
    The AAA-ATPase VCP (also known as p97 or CDC48) uses ATP hydrolysis to 'segregate' ubiquitylated proteins from their binding partners...
  53. Gorbea C, Taillandier D, Rechsteiner M. Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7. J Biol Chem. 2000;275:875-82 pubmed
    ..H., Rubin, D. M., Coux, O., Wefes, I., Pfeifer, G., Cejka, Z., Baumeister, W., Fried, V. A., and Finley, D. (1998) Cell 94, 615-623). ..
  54. Hiraishi N, Ishida Y, Nagahama M. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74. Biochem Biophys Res Commun. 2015;467:534-40 pubmed publisher
    ..activities) family, which exhibits a high level of amino acid sequence similarity with the cytosolic AAA-ATPase VCP/p97. These proteins generally act on macromolecular complexes to stimulate energy-dependent release of their ..
  55. Su V, Hoang C, Geerts D, Lau A. CIP75 (connexin43-interacting protein of 75 kDa) mediates the endoplasmic reticulum dislocation of connexin43. Biochem J. 2014;458:57-67 pubmed publisher
    ..This Cx43-CIP75 complex also contained the proteasomal subunits S2/Rpn1 and S5a/Rpn10, as demonstrated by co-immunoprecipitation...
  56. Lee T, Kang M, Kim C, Schultz P, Chapman E, Deniz A. Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding. Chembiochem. 2016;17:981-4 pubmed publisher
    Many cellular functions are critically dependent on the folding of complex multimeric proteins, such as p97, a hexameric multidomain AAA+ chaperone...
  57. Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, et al. The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100. J Biol Chem. 2015;290:19558-68 pubmed publisher
    ..Here, we uncovered a role of the p97-Npl4-Ufd1 complex in mediating p100-to-p52 processing and therefore positively regulating the alternative NF-κB ..
  58. Papadopoulos C, Meyer H. Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy. Curr Biol. 2017;27:R1330-R1341 pubmed publisher
    ..is ensured by additional layers of regulation, including modulation by the ubiquitin-directed AAA-ATPase VCP/p97. Lysophagy shares many features with mitophagy, the macroautophagic removal of damaged mitochondria...
  59. Jang J, Park K, Lee J, Ko K, Kang S, Kim I. Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation. Biochem Biophys Res Commun. 2017;486:444-450 pubmed publisher
    ..The interaction of C99 with p97(VCP), an essential component of the ERAD complex, did not occur in SelS knock-down cells...
  60. Køhler J, Tammsalu T, Jørgensen M, Steen N, Hay R, Thon G. Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast. Nat Commun. 2015;6:8827 pubmed publisher
    ..by SUMO-targeted ubiquitin ligases (STUbLs) and it has been proposed that the ubiquitin-selective chaperone Cdc48/p97-Ufd1-Npl4 facilitates this process...
  61. Lim J, Lee Y, Ly T, Kang J, Lee J, An J, et al. Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4. Biochem J. 2016;473:2863-80 pubmed publisher
    ..Interaction of valosin-containing protein (p97/VCP) and RHBDL4 is crucial to retrotranslocate polyubiquitinated substrates for ERAD pathway...
  62. Song H, Donner D. Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. Biochem J. 1995;309 ( Pt 3):825-9 pubmed
    ..The TRAP identified in the present study shares considerable homology with, and may be the human homologue of, a mouse protein, TNF receptor-associated factor 2 (TRAF2), that binds mouse TNFR-2. ..
  63. Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer S, Yan Y, et al. 2.3 Ã… resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science. 2016;351:871-5 pubmed publisher
    b>p97 is a hexameric AAA+ adenosine triphosphatase (ATPase) that is an attractive target for cancer drug development...
  64. van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, et al. VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Mol Cell. 2016;64:189-198 pubmed publisher
    ..reconstitution of DSB repair on beads, we demonstrate here that DNA-locked Ku rings are released by the AAA-ATPase p97. To achieve this, p97 requires ATP hydrolysis, cooperates with the Ufd1-Npl4 ubiquitin-adaptor complex, and ..
  65. Schütz A, Rennella E, Kay L. Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
    b>p97/VCP, a member of the AAA+ (ATPases associated with diverse cellular activities) family of proteins, is implicated in the etiology of a group of degenerative diseases affecting bone and muscle tissue as well as the central nervous ..
  66. Diletti G, Scortichini G, Abete M, Binato G, Candeloro L, Ceci R, et al. Intake estimates of dioxins and dioxin-like polychlorobiphenyls in the Italian general population from the 2013-2016 results of official monitoring plans in food. Sci Total Environ. 2018;627:11-19 pubmed publisher
    ..Computed target levels fall between P50 and P97 of the occurrence distribution of the main food groups, meaning that most of the Italian food production can be ..
  67. Meyer H. Golgi reassembly after mitosis: the AAA family meets the ubiquitin family. Biochim Biophys Acta. 2005;1744:481-92 pubmed
    ..Two AAA ATPases, NSF and p97/VCP, have been implicated in regulating membrane fusion steps that lead to regrowth of Golgi cisternae from mitotic ..
  68. Jin Y, Zeng S, Sun X, Lee H, Blattner C, Xiao Z, et al. MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol Cell Biol. 2008;28:1218-29 pubmed
    ..These results demonstrate that MDMX and MDM2 independently and cooperatively regulate the proteasome-mediated degradation of p21 at the G(1) and early S phases. ..
  69. Ikeda Y, Demartino G, Brown M, Lee J, Goldstein J, Ye J. Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. J Biol Chem. 2009;284:34889-900 pubmed publisher
    ..This binding depends on at least two factors, ubiquitination of Insig and association with the ATPase p97/VCP complex...
  70. Yun J, Ko S, Lee C, Cheong H, Cheong C, Yoon J, et al. Solution structure and Rpn1 interaction of the UBL domain of human RNA polymerase II C-terminal domain phosphatase. PLoS ONE. 2013;8:e62981 pubmed publisher
    ..The positively charged residues of the ?3-?2 loop are involved in interacting with the C-terminal leucine-rich repeat-like domain of Rpn1.
  71. Greenblatt M, Park K, Oh H, Kim J, Shin D, Lee J, et al. CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. J Exp Med. 2015;212:1283-301 pubmed publisher
    ..analysis demonstrated that CHMP5 cooperates with the PDB genetic risk factor valosin-containing protein (VCP/p97) to stabilize the inhibitor of NF-κBα (IκBα), down-regulating ubiquitination of IκBα via the ..
  72. Fu X, Liu R, Sanchez I, Silva Sanchez C, Hepowit N, Cao S, et al. Ubiquitin-Like Proteasome System Represents a Eukaryotic-Like Pathway for Targeted Proteolysis in Archaea. MBio. 2016;7: pubmed publisher
    ..Rapid turnover of TBP2 required the functions of UbaA (the E1/MoeB/ThiF homolog of archaea), AAA ATPases (Cdc48/p97 and Rpt types), a type 2 JAB1/MPN/MOV34 metalloenzyme (JAMM/MPN+) homolog (JAMM2), and 20S proteasomes...
  73. Li Z, Wang Y, Xu M, Jiang T. Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase. Biochem Biophys Res Commun. 2017;486:94-100 pubmed publisher
    In humans, UBXD7 (also called UBXN7), an adaptor of p97 ATPase, can participate in the degradation of misfolded or damaged proteins in the p97-mediated ubiquitin proteasome system (UPS)...
  74. Chojnacki M, Mansour W, Hameed D, Singh R, El Oualid F, Rosenzweig R, et al. Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit. Cell Chem Biol. 2017;24:443-457.e6 pubmed publisher
    ..into chains of defined lengths and linkage types provided a set of reagents that led to identification of Rpn1 as a third proteasome ubiquitin-associating subunit that coordinates docking of substrate shuttles, unloading of ..
  75. Jiang J, Tang C, Ren J, Zhang C, Dong L, Zhu Z. Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities. Pediatr neonatol. 2018;59:154-160 pubmed publisher
    ..The ability of learning and memory was assessed using the Morris water maze at P37 and P97. The hippocampal volume was measured by magnetic resonance imaging (MRI) at P37 and P97...
  76. Bengtsson T, Ahman I, Manninen O, Reitan L, Christerson T, Due Jensen J, et al. A Novel QTL for Powdery Mildew Resistance in Nordic Spring Barley (Hordeum vulgare L. ssp. vulgare) Revealed by Genome-Wide Association Study. Front Plant Sci. 2017;8:1954 pubmed publisher
    ..of the SNP markers within the novel QTL predicted the responsible gene to be the 26S proteasome regulatory subunit, RPN1, which is required for innate immunity and powdery mildew-induced cell death in Arabidopsis...
  77. Tsurumi C, Shimizu Y, Saeki M, Kato S, DeMartino G, Slaughter C, et al. cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11. Eur J Biochem. 1996;239:912-21 pubmed
    Molecular cloning of cDNA for a new regulatory subunit, designated p97, of the human 26S proteasome showed that the polypeptide consists of 908 amino acid residues with a calculated molecular mass of 100184 Da and an isoelectric point of ..
  78. Li X, Su V, Kurata W, Jin C, Lau A. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43. J Biol Chem. 2008;283:5748-59 pubmed
    ..Interestingly, the UbL domain interacts with the S2/RPN1 and S5a/RPN10 protein subunits of the regulatory 19 S proteasome cap subunit of the 26 S proteasome complex...
  79. McCauley J, Zuvich R, Bradford Y, Kenealy S, Schnetz Boutaud N, Gregory S, et al. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. Genes Immun. 2009;10:624-30 pubmed publisher
    ..We found preliminary evidence to suggest that common variation within the RGS7 locus may be involved in disease susceptibility. ..
  80. den Besten W, Verma R, Kleiger G, Oania R, Deshaies R. NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol. 2012;19:511-6, S1 pubmed publisher
    The AAA+ ATPase p97 and its UBA-UBX cofactors are thought to extract ubiquitinated proteins from membranes or protein complexes as a prelude to their degradation...
  81. Yi Z, Yuan Z. Aggregation of a hepatitis C virus replicase module induced by ablation of p97/VCP. J Gen Virol. 2017;98:1667-1678 pubmed publisher
    ..as a model and employing affinity purification of the viral replicase, we identified a valosin-containing protein (p97/VCP), a member of the ATPases associated with diverse cellular activities (AAA+ ATPase family), as a viral ..
  82. Rao M, Williams D, Cocklin S, Loll P. Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding. J Biol Chem. 2017;292:18392-18407 pubmed publisher
    b>p97 is an essential ATPase associated with various cellular activities (AAA+) that functions as a segregase in diverse cellular processes, including the maintenance of proteostasis...
  83. Smith L, Qutob O, Watson M, Beavis A, Potts D, Welham K, et al. Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?. Neoplasia. 2009;11:1194-207 pubmed
    ..05) in a small pilot immunohistochemical study. These findings suggest that the 26S proteasome may provide a general predictive biomarker for radiotherapy outcome. ..
  84. Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, et al. Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets. Mol Biol Cell. 2012;23:800-10 pubmed publisher
    ..Depletion of UBXD8, which is almost confined to LDs in this cell type, decreases recruitment of p97 to LDs and causes an increase of both ubiquitinated ApoB on the LD surface and lipidated ApoB in the ER lumen...
  85. Rani N, Aichem A, Schmidtke G, Kreft S, Groettrup M. FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis. Nat Commun. 2012;3:749 pubmed publisher
    ..identify the 26S proteasome subunit hRpn10/S5a as the receptor for FAT10, whereas NUB1L can bind to both Rpn10 and Rpn1/S2. Unexpectedly, FAT10 and NUB1L both interact with hRpn10 via the VWA domain...
  86. Nijhawan D, Zack T, Ren Y, Strickland M, Lamothe R, Schumacher S, et al. Cancer vulnerabilities unveiled by genomic loss. Cell. 2012;150:842-54 pubmed publisher
    ..Normal cells express excess PSMC2, which resides in a complex with PSMC1, PSMD2, and PSMD5 and acts as a reservoir protecting cells from PSMC2 suppression...
  87. Chu B, Kovary K, Guillaume J, Chen L, Teruel M, Wandless T. The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates. J Biol Chem. 2013;288:34575-87 pubmed publisher
    ..Finally, knockdown renders cells more susceptible to the Hsp90 inhibitor 17-AAG, suggesting that UBE3C protects against the harmful accumulation of protein fragments arising from incompletely degraded proteasome substrates. ..
  88. Hochrainer K, Pejanovic N, Olaseun V, Zhang S, Iadecola C, Anrather J. The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic Acids Res. 2015;43:9889-904 pubmed publisher
    ..Our findings establish HERC3 as novel candidate regulating the inflammatory response initiated by NF-κB. ..
  89. Ramadan K, Halder S, Wiseman K, Vaz B. Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication. Chromosoma. 2017;126:17-32 pubmed publisher
    ..of evidence has alluded to a central role in replisome regulation for the ubiquitin-dependent protein segregase p97, also known as valosin-containing protein (VCP) in metazoans and Cdc48 in lower eukaryotes...
  90. Wargachuk R, Glazkova I, Audet N, Pétrin D, Trieu P, Hebert T. VCP/p97 regulates ?2AR quality control during receptor biosynthesis. Cell Signal. 2017;30:50-58 pubmed publisher
    ..Degradation (ERAD) quality control system [1], including the valosin-containing protein (VCP/p97)...
  91. Wang T, Wang B, Huang H, Zhang C, Zhu Y, Pei B, et al. Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication. PLoS Pathog. 2017;13:e1006674 pubmed publisher
    ..b>p97 was identified as a host factor in EV71 replication; it redistributed and co-exists with the viral protein and ..
  92. Hamazaki J, Sasaki K, Kawahara H, Hisanaga S, Tanaka K, Murata S. Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Mol Cell Biol. 2007;27:6629-38 pubmed
    ..Our results demonstrate that Rpn10-mediated degradation of ubiquitinated proteins, catalyzed by UIMs, is indispensable for mammalian life. ..