PSMB9

Summary

Gene Symbol: PSMB9
Description: proteasome subunit beta 9
Alias: LMP2, PSMB6i, RING12, beta1i, proteasome subunit beta type-9, large multifunctional peptidase 2, low molecular mass protein 2, macropain chain 7, multicatalytic endopeptidase complex chain 7, proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2), proteasome catalytic subunit 1i, proteasome chain 7, proteasome subunit beta 6i, proteasome subunit beta-1i, proteasome-related gene 2, really interesting new gene 12 protein
Species: human
Products:     PSMB9

Top Publications

  1. Moschonas A, Kouraki M, Knox P, Thymiakou E, Kardassis D, Eliopoulos A. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol Cell Biol. 2008;28:6208-22 pubmed publisher
    ..the genes encoding transporter for antigen processing 1 (TAP1), TAP2, tapasin, and low-molecular-mass polypeptides LMP2 and LMP10...
  2. Aki M, Shimbara N, Takashina M, Akiyama K, Kagawa S, Tamura T, et al. Interferon-gamma induces different subunit organizations and functional diversity of proteasomes. J Biochem. 1994;115:257-69 pubmed
    ..IFN-gamma greatly increased the levels of the mRNAs encoding LMP2 and LMP7, putative immuno-proteasome subunits encoded by genes within the class II MHC region, and these two ..
  3. Mishto M, BonaFe M, Salvioli S, Olivieri F, Franceschi C. Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. Exp Gerontol. 2002;37:301-8 pubmed
    ..mediator of nonlysosomal protein degradation, are replaced with other subunits, the large multifunctional proteases LMP2 and LMP7, thus originating the immunoproteasome...
  4. Zhu X, Zhang Y, Wang Q, Wang F. Polymorphisms of TAP, LMP and HLA-DM genes in the Chinese. Chin Med J (Engl). 2000;113:372-5 pubmed
    ..of antigen-processing genes transporter associated with antigen processing (TAP), low molecular weight proteasome (LMP2) and HLA-DM in the Shanghai population and to explore the possible role of these genes in the genetic ..
  5. Vargas Alarcon G, Gamboa R, Zuniga J, Fragoso J, Hernández Pacheco G, Londoño J, et al. Association study of LMP gene polymorphisms in Mexican patients with spondyloarthritis. Hum Immunol. 2004;65:1437-42 pubmed
    ..LMP genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The LMP2 and LMP7 allele frequencies were similar in patients and healthy controls...
  6. Wang H, Wang H, Lin H, Yang Q, Zhang H, Tsang B, et al. Proteasome subunit LMP2 is required for matrix metalloproteinase-2 and -9 expression and activities in human invasive extravillous trophoblast cell line. J Cell Physiol. 2006;206:616-23 pubmed
    ..b>LMP2 is an important proteasome subunit that is critical for proteasome activity...
  7. Zhang H, Sun L, Liang J, Yu W, Zhang Y, Wang Y, et al. The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. EMBO J. 2006;25:4223-33 pubmed
    ..coactivator (SRC)-interacting proteins using yeast two-hybrid system, we found that the 20S proteasome beta subunit LMP2 (Low Molecular mass Polypeptide 2) interacts directly with the SRC coactivators...
  8. Kramer U, Illig T, Grune T, Krutmann J, Esser C. Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype. Genes Immun. 2007;8:513-7 pubmed
    ..We test here whether variants of immunoproteasome subunits LMP2 and LMP7, or antigen peptide transport proteins TAP1 (transporters associated with antigen presentation) and TAP2 ..
  9. Morawietz L, Martinez Gamboa L, Scheffler S, Hausdorf G, Dankof A, Kuckelkorn U, et al. Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome. J Rheumatol. 2009;36:2694-703 pubmed publisher
    ..Minor salivary gland specimens were analyzed to investigate dysregulation of the proteasome system in patients with Sjögren's syndrome (SS) and patients with sicca syndrome...

More Information

Publications115 found, 100 shown here

  1. Mishto M, Bellavista E, Ligorio C, Textoris Taube K, Santoro A, Giordano M, et al. Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population. PLoS ONE. 2010;5:e9287 pubmed publisher
    ..on 1262 Italian MS cases and 845 controls we observed that HLA-A*02+ female subjects carrying the immunoproteasome LMP2 codon 60HH variant have a reduced risk to develop MS...
  2. Vargas Alarcon G, Gamboa R, Vergara Y, Rodriguez Zepeda J, de la Pena A, Izaguirre R, et al. LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians. Genes Immun. 2002;3:373-7 pubmed
    ..In order to define the distribution of LMP genes in Mexican populations, the LMP2 and LMP7 polymorphism was analyzed in 312 Mexican individuals (95 Mexican Mestizos, 48 Nahuas, 56 Mazatecans, 50 ..
  3. Seifert U, Bialy L, Ebstein F, Bech Otschir D, Voigt A, Schröter F, et al. Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell. 2010;142:613-24 pubmed publisher
  4. Suzuki K, Yanagi M, Mori Aoki A, Moriyama E, Ishii K, Kohn L. Transfection of single-stranded hepatitis A virus RNA activates MHC class I pathway. Clin Exp Immunol. 2002;127:234-42 pubmed
    ..single-stranded hepatitis A virus RNA into cultured hepatocytes results in the induction of genes for MHC class I, LMP2 and transporter for antigen processing (TAP1), in addition to the generation of viral proteins...
  5. Seliger B, Atkins D, Bock M, Ritz U, Ferrone S, Huber C, et al. Characterization of human lymphocyte antigen class I antigen-processing machinery defects in renal cell carcinoma lesions with special emphasis on transporter-associated with antigen-processing down-regulation. Clin Cancer Res. 2003;9:1721-7 pubmed
    ..Concomitant TAP1 and LMP2 deficiencies were found in approximately 57% of RCC lesions, whereas a coordinated down-regulation of all APM ..
  6. Liu X, Wu X, Zhu X, Li T, Liu Y. IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species. Int Immunopharmacol. 2017;48:76-83 pubmed publisher
    ..Besides, IRG1 increased expression of some transporter proteins associated with antigen processing involving TAP1, PSMB9 depending on ROS...
  7. Li J, Huang Z, Xiong G, Mo H, Qiu F, Mai H, et al. Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma. J Transl Med. 2011;9:189 pubmed publisher
    ..Moreover, we demonstrated the existence of Epstein-Barr virus latent membrane protein (LMP) 1 and LMP2 antigen-specific Tcregs in NPC...
  8. Flori L, Rogel Gaillard C, Mariani V, Lemonnier G, Cochet M, Hugot K, et al. A combined transcriptomic approach to analyse the dialogue between pseudorabies virus and porcine cells. Dev Biol (Basel). 2008;132:99-104 pubmed
    ..involved in the MHC class I mediated antigenic pathway were downregulated including SLA-la, TAP1, TAP2, PSMB8 and PSMB9 genes...
  9. Sewell A, Price D, Teisserenc H, Booth B, Gileadi U, Flavin F, et al. IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase. J Immunol. 1999;162:7075-9 pubmed
    ..by treatment with lactacystin, and is independent of expression of the IFN-gamma-inducible proteasome beta subunits LMP2 and LMP7...
  10. Velasco C, Bonacic K, Soengas J, Morais S. Orally administered fatty acids enhance anorectic potential but do not activate central fatty acid sensing in Senegalese sole post-larvae. J Exp Biol. 2017;220:677-685 pubmed publisher
    ..presence of a FA-sensing system, but most genes either were not significantly regulated (fat/cd36-lmp2, acly, kir6...
  11. Chen L, Yang Y, Wang Y, Qiu L, Xia H, Wang A, et al. Proteomic Response of the Rat Liver in Differential Swimming Modes. Clin Exp Pharmacol Physiol. 2017;: pubmed publisher
    ..RGN, PSMB9, and AGT, commonly recognized as oxidative stress biomarkers, may involve in regulating homeostasis in the ..
  12. He K, Li W, Guan D, Gong M, Ye S, Fang Z, et al. Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets. Funct Integr Genomics. 2019;: pubmed publisher
    ..interactions in our reconstructed network covering all of five miRNAs, and several essential factors such as PSMB9, HLA-C, RARRES3, UBE2L6, and NMI...
  13. Treise I, Huber E, Klein Rodewald T, Heinemeyer W, Grassmann S, Basler M, et al. Defective immuno- and thymoproteasome assembly causes severe immunodeficiency. Sci Rep. 2018;8:5975 pubmed publisher
    ..In contrast to the immunosubunits β1i (LMP2) and β5i (LMP7), mutations in the gene encoding MECL-1 have not yet been assigned to human disorders...
  14. Sethumadhavan S, Silva M, Philbrook P, Nguyen T, Hatfield S, Ohta A, et al. Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. PLoS ONE. 2017;12:e0187314 pubmed publisher
    ..presentation, hyperoxia (60% oxygen) transcriptionally upregulated MHC expression and increased levels of TAP2, LMP2 and 7...
  15. Murray B, Sultmann H, Klein J. Analysis of a 26-kb region linked to the Mhc in zebrafish: genomic organization of the proteasome component beta/transporter associated with antigen processing-2 gene cluster and identification of five new proteasome beta subunit genes. J Immunol. 1999;163:2657-66 pubmed
    ..In addition to homologues of the human genes PSMB5 through PSMB9, two new genes, PSMB11 and PSMB12, have been found for which there are no known corresponding genes in humans...
  16. van Endert P, Lopez M, Patel S, Monaco J, McDevitt H. Genomic polymorphism, recombination, and linkage disequilibrium in human major histocompatibility complex-encoded antigen-processing genes. Proc Natl Acad Sci U S A. 1992;89:11594-7 pubmed
    ..These studies demonstrate a strong linkage disequilibrium between TAP1 and LMP2 RFLPs...
  17. Gan C, Yusof R, Othman S. Different serotypes of dengue viruses differently regulate the expression of the host cell antigen processing machinery. Acta Trop. 2015;149:8-14 pubmed publisher
    ..Cellular RNA were isolated from infected cells and the gene expressions of LMP2, LMP7, TAP1, TAP2, TAPBP, CALR, CANX, PDIA3, HLA-A and HLA-B were analyzed via quantitative PCR...
  18. Mayes K, Alkhatib S, Peterson K, Alhazmi A, Song C, Chan V, et al. BPTF Depletion Enhances T-cell-Mediated Antitumor Immunity. Cancer Res. 2016;76:6183-6192 pubmed
    ..revealed that NURF directly regulated the expression of genes encoding immunoproteasome subunits Psmb8 and Psmb9 and the antigen transporter genes Tap1 and Tap2 The PSMB8 inhibitor ONX-0914 reversed the effects of BPTF ablation,..
  19. Downs I, Vijayan S, Sidiq T, Kobayashi K. CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression. Biofactors. 2016;42:349-57 pubmed publisher
    ..In addition to MHC class I genes, CITA/NLRC5 induces the expression of ?2 -microglobulin, TAP1 and LMP2, essential components of the MHC class I antigen presentation pathway...
  20. Liang J, Cui Y, Meng Y, Li X, Wang X, Liu W, et al. Integrated analysis of transcription factors and targets co-expression profiles reveals reduced correlation between transcription factors and target genes in cancer. Funct Integr Genomics. 2019;19:191-204 pubmed publisher
    ..Some of these pairs like XRCC5-XRCC6 have been reported to involve in multiple cancers, while pairs like IRF1-PSMB9 without any previous articles related to tumor but involve in the biological processes of cancer, which are of ..
  21. Kempkes B, Robertson E. Epstein-Barr virus latency: current and future perspectives. Curr Opin Virol. 2015;14:138-44 pubmed publisher
    ..and super-enhancer functions of the latent nuclear antigens in regulating cellular transcription; the role of LMP2 in utilization of the autophagosome to control cell death, and the association between LMP1, the linear ubiquitin ..
  22. Hayashi T, Ichimura T, Kasai M, Sano K, Zharhary D, Shiozawa T, et al. Characterization of Leiomyomatoid Angiomatous Neuroendocrine Tumour (LANT)-like Tumour in the Myometrium with Histopathological Examination. Anticancer Res. 2017;37:1765-1772 pubmed
    ..e. leiomyosarcomas. From our research, defective expression of calponin H1 and proteasome ?9 (PSMB9)/?1i is observed in uterine LANT-like malignant tumour similarly to immunopathological findings of uterine ..
  23. Middeldorp J. Epstein-Barr Virus-Specific Humoral Immune Responses in Health and Disease. Curr Top Microbiol Immunol. 2015;391:289-323 pubmed publisher
    ..Humoral immune responses against EBV-encoded tumour antigens LMP1, LMP2 and BARF1 are addressed, which provide novel options for targeted immunotherapy...
  24. Casp C, She J, McCormack W. Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo. Genes Immun. 2003;4:492-9 pubmed
    ..alleles from heterozygous parents to affected offspring for the TAP1 gene, as well as for the closely linked LMP2 and LMP7 genes encoding subunits of the immunoproteasome...
  25. Ren Y, Zhang Y, Liu R, Fenstermacher D, Wright K, Teer J, et al. JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations. Sci Rep. 2013;3:3042 pubmed publisher
    ..Functional assays show that JAK1 deficient cancer cells are defective in IFN-?-induced LMP2 and TAP1 expression, loss of which inhibits presentation of tumor antigens...
  26. Yoshihama S, Roszik J, Downs I, Meissner T, Vijayan S, Chapuy B, et al. NLRC5/MHC class I transactivator is a target for immune evasion in cancer. Proc Natl Acad Sci U S A. 2016;113:5999-6004 pubmed publisher
    ..class I, with cytotoxic T-cell markers, and with genes in the MHC class I antigen-presentation pathway, including LMP2/LMP7, TAP1, and ?2-microglobulin...
  27. O Grady T, Wang X, Honer zu Bentrup K, Baddoo M, Concha M, Flemington E. Global transcript structure resolution of high gene density genomes through multi-platform data integration. Nucleic Acids Res. 2016;44:e145 pubmed
    ..g. across the IR1 repeats), alternative promoter usage by LMP2 and other latency-associated transcripts, intergenic splicing at the BZLF2 locus, and antisense transcription and ..
  28. Choi J, Jo H, Lim S, Kim H, Lee K, Moon K, et al. mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018;9:2502 pubmed publisher
    ..We also show that concomitant loss of immunoproteasome subunit Psmb9, which is induced by Stat1 (signal transducer and activator of transcription factor 1), decelerates cell cycle ..
  29. McLaughlin L, Gottschalk S, Rooney C, Bollard C. EBV-Directed T Cell Therapeutics for EBV-Associated Lymphomas. Methods Mol Biol. 2017;1532:255-265 pubmed
    ..strategies are needed to manufacture EBV-specific T cell products specific for Latent Membrane Protein 1 (LMP1) and LMP2, which are expressed in lymphomas with type II and III latency...
  30. Satoh E, Mabuchi T, Satoh H, Asahara T, Nukui H, Naganuma H. Reduced expression of the transporter associated with antigen processing 1 molecule in malignant glioma cells, and its restoration by interferon-gamma and -beta. J Neurosurg. 2006;104:264-71 pubmed
    ..processing 1 (TAP1), which transports antigens to MHC Class I molecules, and low-molecular-mass polypeptide 2 (LMP2), which is a subunit of a proteasome...
  31. Gregorovic G, Boulden E, Bosshard R, Elgueta Karstegl C, Skalsky R, Cullen B, et al. Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice. J Virol. 2015;89:11711-4 pubmed publisher
    ..Deletion of EBER1 or EBER2 correlated with increased levels of cytoplasmic EBV LMP2 RNA and with small effects on specific cellular microRNA (miRNA) levels, but protein levels of LMP1 and LMP2A were ..
  32. Xu B, Li S, Lv W, Wang Y, Li X, Zhang L, et al. Transcriptomic analysis reveals the underlying pro-malignant functions of Gankyrin for colorectal cancer via affecting tumor necrosis factor pathway. Int J Biol Macromol. 2018;117:1011-1016 pubmed publisher
    ..A PPI network including 586 nodes and 654 edges was constructed, in which BIRC3 and PSMB9 were demonstrated to be the hub genes associated with Gankyrin...
  33. Stepanova A, Lyupina Y, Sharova N, Erokhov P. Native structure of rat liver immune proteasomes. Dokl Biochem Biophys. 2016;468:200-2 pubmed publisher
    ..The developed method allowed revealing the proteasome immune subunits LMP7 and LMP2 in 20S subparticles and in the structures bound to one or two PA28?? activators, but not to the PA700 activator, ..
  34. Tierney R, Shannon Lowe C, Fitzsimmons L, Bell A, Rowe M. Unexpected patterns of Epstein-Barr virus transcription revealed by a high throughput PCR array for absolute quantification of viral mRNA. Virology. 2015;474:117-30 pubmed publisher
    ..Analysis of seven African BL biopsies confirmed this transcription profile but additionally revealed significant expression of LMP2 transcripts.
  35. Froment C, Uttenweiler Joseph S, Bousquet Dubouch M, Matondo M, Borges J, Esmenjaud C, et al. A quantitative proteomic approach using two-dimensional gel electrophoresis and isotope-coded affinity tag labeling for studying human 20S proteasome heterogeneity. Proteomics. 2005;5:2351-63 pubmed
    ..The results obtained show that this approach represents a valuable tool for the study of 20S proteasome heterogeneity. ..
  36. Xiao Z, Ye Z, Tadwal V, Shen M, Ren E. Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens. Sci Rep. 2017;7:5072 pubmed publisher
    ..Here, we show that single short peptides of <8-mer from Latent Membrane Protein 2 (LMP2) of Epstein Barr Virus (EBV) can bind HLA-A*11:01 and stimulate CD8+ cells...
  37. Romero J, Jimenez P, Cabrera T, Cozar J, Pedrinaci S, Tallada M, et al. Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer. Int J Cancer. 2005;113:605-10 pubmed
    ..of HLA-ABC, beta2-microglobulin and the members of the antigen processing machinery (APM) of HLA class I molecules (LMP2, LMP7, TAP1, TAP2 and tapasin)...
  38. Ohta Y, Powis S, Coadwell W, Haliniewski D, Liu Y, Li H, et al. Identification and genetic mapping of Xenopus TAP2 genes. Immunogenetics. 1999;49:171-82 pubmed
    ..Class IIbeta, class Ia, LMP2, LMP7, HSP70, C4, Factor B, and Ring3 genes have been identified and mapped to the MHC...
  39. Chistyakov D, Savost anov K, Turakulov R, Petunina N, Trukhina L, Kudinova A, et al. Complex association analysis of graves disease using a set of polymorphic markers. Mol Genet Metab. 2000;70:214-8 pubmed
    ..encode cytotoxic T-lymphocyte-associated serine esterase-4 (CTLA4), subunit 2 of large multifunctional protease (LMP2), thyroid-stimulating hormone receptor (TSHR), and interleukin 1 receptor antagonist (IL1RN)...
  40. Bose S, Brooks P, Mason G, Rivett A. gamma-Interferon decreases the level of 26 S proteasomes and changes the pattern of phosphorylation. Biochem J. 2001;353:291-7 pubmed
    ..The majority of the gamma-IFN-inducible proteasome subunits LMP2 and LMP7 were present in PA28-proteasome complexes, but these subunits were also found in 26 S proteasomes...
  41. Shi C, Qian Y, Su J, Luo S, Gu J, You H, et al. Genetic variation in the LMP/TAP gene and outcomes of hepatitis B virus infection in the Chinese population. Epidemiol Infect. 2011;139:674-82 pubmed publisher
    ..These findings indicated that genetic polymorphisms of the LMP/TAP gene might be an important factor in determining the outcome of HBV infection. ..
  42. Hayashi T, Horiuchi A, Sano K, Yaegashi N, Konishi I. Uterine Leiomyosarcoma Tumorigenesis in Lmp2-deficient Mice: Involvement of Impaired Anti-oncogenic Factor IRF1. Anticancer Res. 2015;35:4665-79 pubmed
    ..We have previously reported that low molecular mass protein2 Lmp2-deficient mice spontaneously developed Ut-LMS, which implicated this protein as an anti-oncogenic candidate...
  43. Schmidt M, Zantopf D, Kraft R, Kostka S, Preissner R, Kloetzel P. Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex. J Mol Biol. 1999;288:117-28 pubmed
    ..functional impact of proteasomal prosequences during complex formation, the propeptide of the facultative subunit beta1i/LMP2 was truncated to nine amino acid residues or completely deleted...
  44. Mo M, Huang W, Sun C, Zhang L, Cen L, Xiao Y, et al. Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease. Chin Med J (Engl). 2016;129:1053-8 pubmed publisher
    ..A case-control study was conducted by genotyping SNPs in PSMB8, PSMB9, TAP1, and TAP2 genes in the Chinese population...
  45. Nandi D, Woodward E, Ginsburg D, Monaco J. Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits. EMBO J. 1997;16:5363-75 pubmed
    ..However, antibodies to PSMA3 (C8) and PSMB9 (LMP2) immunoprecipitated complexes made up of alpha and precursor beta but no processed beta subunits...
  46. Johnsen A, France J, Nagy N, Askew D, Abdul Karim F, Gerson S, et al. Systemic deficits in transporter for antigen presentation (TAP)-1 or proteasome subunit LMP2 have little or no effect on tumor incidence. Int J Cancer. 2001;91:366-72 pubmed
    ..deficits in T-cell immunity, including mice lacking TAP1 (a subunit of the transporter for antigen presentation) or LMP2 (a regulated subunit of the 20S proteasome)...
  47. Mehta A, Jordanova E, Corver W, van Wezel T, Uh H, Kenter G, et al. Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. Genes Chromosomes Cancer. 2009;48:410-8 pubmed publisher
    ..Twelve nonsynonymous, coding SNPs in the TAP1, TAP2, LMP2, LMP7, and ERAP1 genes were genotyped in 75 cervical carcinoma patients with known APM component and HLA class I ..
  48. Lin M, Lin Y, Chen S, Young T, Lou P. Therapeutic vaccine targeting Epstein-Barr virus latent protein, LMP1, suppresses LMP1-expressing tumor growth and metastasis in vivo. BMC Cancer. 2017;17:18 pubmed publisher
    ..carcinoma (NPC) tumor cells harbor EBV latent infection and expresses viral antigens such as EBNA1, LMP1 and LMP2. In this study, we established a NPC-mimicry animal model and assessed the therapeutic potential of LMP1 vaccine...
  49. Deshpande A, Wheeler C, Hunt W, Peyton C, White P, Valdez Y, et al. Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer. J Infect Dis. 2008;197:371-81 pubmed publisher
    ..Genetic variation in these genes may affect protein structure and function and, consequently, the ability of an individual to clear HPV infection...
  50. Zhang X, Baladandayuthapani V, Lin H, Mulligan G, Li B, Esseltine D, et al. Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling. Cancer Cell. 2016;29:639-652 pubmed publisher
    ..TJP1 suppressed expression of the catalytically active immunoproteasome subunits LMP7 and LMP2, decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo...
  51. Chen W, Norbury C, Cho Y, Yewdell J, Bennink J. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J Exp Med. 2001;193:1319-26 pubmed
    ..In this study, we use mice lacking one of the immunoproteasome subunits (LMP2) to show that immunoproteasomes play an important role in establishing the immunodominance hierarchy of CD8(+) T ..
  52. Atkins D, Breuckmann A, Schmahl G, Binner P, Ferrone S, Krummenauer F, et al. MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma. Int J Cancer. 2004;109:265-73 pubmed
    ..In comparison to autologous colorectal mucosa, TAP1, LMP2 and tapasin loss was found in 68%, 67% and 80% of HIN, respectively...
  53. Yamazaki K, Umeno J, Takahashi A, Hirano A, Johnson T, Kumasaka N, et al. A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Gastroenterology. 2013;144:781-8 pubmed publisher
    ..27). In a genome-wide association study, we identified 2 new susceptibility loci for Crohn's disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn's disease. ..
  54. Martinez C, Monaco J. Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene. Nature. 1991;353:664-7 pubmed
    ..These observations suggest that the LMP complex may be responsible for generating peptides from cytoplasmic antigen during antigen processing. ..
  55. Perea F, Bernal M, Sánchez Palencia A, Carretero J, Torres C, Bayarri C, et al. The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration. Int J Cancer. 2017;140:888-899 pubmed publisher
    ..produced by a combination of HLA haplotype loss and a transcriptional downregulation of ?2-microglobulin (?2-m) and LMP2 and LMP7 antigen presentation machinery genes...
  56. Zeidler R, Eissner G, Meissner P, Uebel S, Tampe R, Lazis S, et al. Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10. Blood. 1997;90:2390-7 pubmed
    ..Similarly, hIL-10 showed the same activity. Expression of the LMP2 and TAP1 genes but not expression of TAP2 or LMP7 is efficiently downregulated, indicating a specific IL-10 effect ..
  57. Park J, Ao L, Miller Z, Kim K, Wu Y, Jang E, et al. PSMB9 codon 60 polymorphisms have no impact on the activity of the immunoproteasome catalytic subunit B1i expressed in multiple types of solid cancer. PLoS ONE. 2013;8:e73732 pubmed publisher
    ..In particular, the codon 60 polymorphism of the PSMB9 gene encoding the ?1i immunoproteasome catalytic subunit has been investigated in the context of a variety of ..
  58. Huang M, Zhang W, Guo J, Wei X, Phiwpan K, Zhang J, et al. Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation. Sci Rep. 2016;6:33612 pubmed publisher
    ..transgenic mouse model carrying an intact human TAP complex and two human immunoproteasome LMP subunits, PSMB8/PSMB9. By crossing the hTAP-LMP strain with different HLA-I transgenic mice, we found that the expression levels of ..
  59. Li T, Liu C, Yao Y, Yu J, Shi L, Shen Y. [Association of LMP gene polymorphisms with chronic HCV infection among ethnic Han population from Yunnan]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016;33:806-810 pubmed
    ..SNPs rs1351383, rs17587 and rs2127675 from the promoter region of the LMP2 gene and rs2071543 from the promoter region of the LPM7 gene were genotyped using a TaqMan probe...
  60. Ritter C, Fan K, Paschen A, Reker Hardrup S, Ferrone S, Nghiem P, et al. Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma. Sci Rep. 2017;7:2290 pubmed publisher
    ..is caused by an impaired expression of key components of the antigen processing machinery (APM), including LMP2 and LMP7 as well as TAP1 and TAP2...
  61. Nakamura K, Jinnin M, Kudo H, Inoue K, Nakayama W, Honda N, et al. The role of PSMB9 upregulated by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and systemic lupus erythematosus. Br J Dermatol. 2016;174:1030-41 pubmed publisher
    ..Among those proteins, PSMB9, an immunoproteasome subunit, was upregulated in the epidermis of DM and SLE, but not in other skin diseases...
  62. Zhao G, Jiang K, Zhang T, Wu H, Qiu C, Deng G. Specific interferon tau gene-regulation networks in bovine endometrial luminal epithelial cells. Theriogenology. 2018;105:51-60 pubmed publisher
    ..A set of candidate genes (RAC2, DVL3, PSMB9, STAT1, ISG15, JAK1, and MUC1) was identified...
  63. Maksymowych W, Inman R, Gladman D, Reeve J, Pope A, Rahman P. Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis. Arthritis Rheum. 2009;60:1317-23 pubmed publisher
    ..13 coding single-nucleotide polymorphisms (SNPs) from 5 genes involved in antigen processing (ERAP1, TAP1, TAP2, LMP2, and LMP7) in 3 Canadian cohorts of patients with AS, to address the possibility of gene interactions in disease ..
  64. Hisamatsu H, Shimbara N, Saito Y, Kristensen P, Hendil K, Fujiwara T, et al. Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. J Exp Med. 1996;183:1807-16 pubmed
    Interferon (IFN) gamma induces replacements of the proteasomal subunits X and Y by LMP7 and LMP2, respectively, resulting in an alteration of the proteolytic specificity...
  65. Proffitt J, Blair G. The MHC-encoded TAP1/LMP2 bidirectional promoter is down-regulated in highly oncogenic adenovirus type 12 transformed cells. FEBS Lett. 1997;400:141-4 pubmed
    ..We report that levels of MHC-encoded TAP1 and LMP2 mRNAs are also down-regulated in Ad12-transformed rat cells, and that transcription of rat TAP1 and LMP2 ..
  66. Pamer E, Cresswell P. Mechanisms of MHC class I--restricted antigen processing. Annu Rev Immunol. 1998;16:323-58 pubmed
    ..A subset of the proteasome beta-subunits (LMP2, LMP7, and MECL-1) and one of the accessory complexes, PA28, are upregulated by gamma-interferon and affect the ..
  67. Keicho N, Tokunaga K, Nakata K, Taguchi Y, Azuma A, Tanabe K, et al. Contribution of TAP genes to genetic predisposition for diffuse panbronchiolitis. Tissue Antigens. 1999;53:366-73 pubmed
    ..Genes of the molecules implicated in the class I pathway, TAP1, TAP2 and LMP2, which are located in the HLA region of the sixth chromosome were analyzed in 76 patients with diffuse ..
  68. Hansen J, Strassburger P, Thorgaard G, Young W, Du Pasquier L. Expression, linkage, and polymorphism of MHC-related genes in rainbow trout, Oncorhynchus mykiss. J Immunol. 1999;163:774-86 pubmed
    ..Aside from the expected polymorphisms associated with class I genes, LMP2 and TAP2 are polygenic...
  69. Seliger B, Wollscheid U, Momburg F, Blankenstein T, Huber C. Characterization of the major histocompatibility complex class I deficiencies in B16 melanoma cells. Cancer Res. 2001;61:1095-9 pubmed
    ..pathway, including the peptide transporter associated with antigen processing, the proteasome subunits LMP2, LMP7, and LMP10, PA28alpha and -beta, and the chaperone tapasin...
  70. Lee H, Ha S, Han H, Kim J. Distribution of HLA-A, B alleles and polymorphisms of TAP and LMP genes in Korean patients with atopic dermatitis. Clin Exp Allergy. 2001;31:1867-74 pubmed
    ..Atopic dermatitis has been seen to result from multifactorial inheritance, with interaction between genetic and environmental factors. The genetic association may differ according to the ethnic backgrounds...
  71. Fricke B, Heink S, Steffen J, Kloetzel P, Krüger E. The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO Rep. 2007;8:1170-5 pubmed
    ..Thus, POMP facilitates the main steps in 20S core complex formation at the ER to coordinate the assembly process and to provide cells with freshly formed proteasomes at their site of function. ..
  72. Cao B, Dong S, Su Q, Yan B, Zhen H, Yuan Z, et al. Lack of association between the unique LMP2 gene polymorphism and the outcome of lung cancer in a population of Chinese Han nationality. Hum Immunol. 2012;73:580-4 pubmed publisher
    ..In this study we will assess the association of low-molecular-mass protease 2 (LMP2) gene codon 60 polymorphism with the risk of lung cancer...
  73. Savchuk O, Mel nyk V, Goncharov S, Shandiuk V, Stroĭ D, Dosenko V, et al. [Frequency of allele polymorphism of immune proteasome catalytic subunits in patients with ischemic stroke]. Fiziol Zh. 2014;60:49-55 pubmed
    Frequency of allelic variants of proteasome subunits genes LMP2 (Arg60 --> His) and PSMA6 were determined in patients with ischemic stroke using real-time PCR. Allelic variants of PSMA6 were disposed in the next manner: C/C - 80...
  74. Bodmer J, Marsh S, Albert E, Bodmer W, Dupont B, Erlich H, et al. Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. Tissue Antigens. 1992;39:161-73 pubmed
  75. Cruz M, Elenich L, Smolarek T, Menon A, Monaco J. DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene. Genomics. 1997;45:618-22 pubmed
    ..Three of the 10 mammalian proteasome beta subunits (LMP2, LMP7, and LMP10) are induced by IFN-gamma...
  76. Pyo C, Hur S, Kim Y, Kim T, Kim T. Association of TAP and HLA-DM genes with psoriasis in Koreans. J Invest Dermatol. 2003;120:616-22 pubmed
    ..of antigen-processing genes in the pathogenesis of psoriasis, we analyzed the polymorphisms of the TAP1, TAP2, LMP2, LMP7, DMA, and DMB genes in 98 Korean psoriasis patients and compared them with 184 healthy controls...
  77. James A, Conway A, Morris B. Regulation of the neuronal proteasome by Zif268 (Egr1). J Neurosci. 2006;26:1624-34 pubmed
    ..Regulation of the mRNAs encoding the psmb9 (Lmp2) and psme2 (PA28beta) proteasome subunits, along with the proteasome-regulatory kinase serum/glucocorticoid-..
  78. Gharavi A, Kiryluk K, Choi M, Li Y, Hou P, Xie J, et al. Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat Genet. 2011;43:321-7 pubmed publisher
  79. Williams F, Bansal A, van Meurs J, Bell J, Meulenbelt I, Suri P, et al. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis. 2013;72:1141-8 pubmed publisher
    ..This gene has not previously been considered a candidate in LDD and further functional work is needed on this hitherto unsuspected pathway. ..
  80. Elhawary N, Bogari N, Jiffri E, Rashad M, Fatani A, Tayeb M. Transporter TAP1-637G and immunoproteasome PSMB9-60H variants influence the risk of developing vitiligo in the Saudi population. Dis Markers. 2014;2014:260732 pubmed publisher
    We evaluated whether TAP1-rs1135216 (p.637D>G) and PSMB9-rs17587 (p.60R>H) were significantly associated with the risk and severity of vitiligo among Saudi patients...
  81. Wu Y, Liu D, Zhang J, Li X, Lu Z, Shi G, et al. Association between LMP2/LMP7 genetic variability and cancer susceptibility, especially among Asians: evidence from a meta-analysis. Oncotarget. 2017;8:62445-62453 pubmed publisher
    ..Recent studies have reported the association of LMP2-60 G>A (rs17587) and LMP7-145 C>A (rs2071543) polymorphisms with various types of cancers, but the outcomes ..
  82. Yang L, Ji Y, Chen L, Li M, Wu F, Hu J, et al. Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection. PLoS ONE. 2017;12:e0186319 pubmed publisher
    ..paraffin-embedded tumor specimens from the patients and peripheral blood lymphocytes from the controls and used for LMP2/LMP7 genotyping...
  83. Beck S, Abdulla S, Alderton R, Glynne R, Gut I, Hosking L, et al. Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. J Mol Biol. 1996;255:1-13 pubmed
    ..We also report the finding of a class I-related pseudogene (HLA-ZI) in the middle of the class II region, which provides the first direct evidence for DNA exchange between these two related regions in man. ..
  84. Yan G, Fu Y, Faustman D. Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J Immunol. 1997;159:3068-80 pubmed
    The MHC is an essential contributor to autoimmunity. Lmp2 and Tap1 are genes located in the MHC class II region, and they encode proteins participating in the generation and transport of endogenous peptides for T cell education...
  85. Singal D, Ye M, Bienzle D. Transfection of TAP 1 gene restores HLA class I expression in human small-cell lung carcinoma. Int J Cancer. 1998;75:112-6 pubmed
    ..I-deficient human tumor cell lines, including small-cell lung carcinoma, lacked products of MHC-encoded TAP1 and LMP2 genes...
  86. Niesporek S, Meyer C, Kremsner P, May J. Polymorphisms of transporter associated with antigen processing type 1 (TAP1), proteasome subunit beta type 9 (PSMB9) and their common promoter in African children with different manifestations of malaria. Int J Immunogenet. 2005;32:7-11 pubmed
    ..of the antigen processing proteins transporter associated with antigen processing type 1 (TAP1) and proteasome subunit beta type 9 (PSMB9) and of their shared bidirectional promoter was assessed in children with either mild or severe ..
  87. Bravo M, Colmenero J, Queipo Ortuño M, Martin J, Lavado R, Alonso A, et al. No association of TAP and LMP genetic polymorphism in human brucellosis and its complications. Hum Immunol. 2010;71:708-11 pubmed publisher
    ..This study suggests that larger studies will be needed to confirm or rule out the possible association of the TAP2A/TAP2F genotype or other possible associations with focal forms of brucellosis...
  88. Zheng G, Chaux A, Sharma R, Netto G, Caturegli P. LMP2, a novel immunohistochemical marker to distinguish renal oncocytoma from the eosinophilic variant of chromophobe renal cell carcinoma. Exp Mol Pathol. 2013;94:29-32 pubmed publisher
    b>LMP2 is a subunit of the immunoproteasome that is overexpressed in oncocytic lesions of the thyroid gland...
  89. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Ichimura T, Sudo T, et al. Potential diagnostic biomarkers: differential expression of LMP2/β1i and cyclin B1 in human uterine leiomyosarcoma. Tumori. 2014;100:99e-106e pubmed publisher
    ..Interestingly, mice that were homozygously deficient for LMP2/β1i were found to spontaneously develop Ut-LMS and exhibited a Ut-LMS prevalence of ~40% by 14 months of age...
  90. Yucesoy B, Talzhanov Y, Michael Barmada M, Johnson V, Kashon M, Baron E, et al. Association of MHC region SNPs with irritant susceptibility in healthcare workers. J Immunotoxicol. 2016;13:738-44 pubmed publisher
    ..In addition, SNPs in PSMB9 (rs10046277 and ITPR3 (rs499384) were associated with hand dermatitis...
  91. McConnell S, Hernandez K, Wcisel D, Kettleborough R, Stemple D, Yoder J, et al. Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. Proc Natl Acad Sci U S A. 2016;113:E5014-23 pubmed publisher
    ..each of three major trifurcations of catalytic-type proteasome subunits in vertebrates: Psmb5/Psmb8/Psmb11, Psmb6/Psmb9/Psmb12, and Psmb7/Psmb10/Psmb13...
  92. Gvozdeva O, Gladkih D, Chernikov I, Meschaninova M, Venyaminova A, Zenkova M, et al. Nuclease-resistant 63 bp trimeric siRNAs (tsiRNA) simultaneously silence three different genes in tumor cells. FEBS Lett. 2017;: pubmed publisher
    ..bp tsiRNA (trimeric small interfering RNA) comprising in one duplex the sequence of siRNAs targeting mRNAs of MDR1, LMP2 and LMP7 genes...