PSEN2

Summary

Gene Symbol: PSEN2
Description: presenilin 2 (Alzheimer disease 4)
Alias: AD3L, AD4, CMD1V, PS2, STM2, AD3LP, AD5, E5-1, PS-2, STM-2, presenilin-2
Species: human

Top Publications

  1. pmc Interaction of presenilins with the filamin family of actin-binding proteins
    W Zhang
    Department of Pediatrics and Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 18:914-22. 1998
  2. ncbi Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas
    Yun gang Zhang
    Department of Pathology, Peking University Health Science Center, Beijing, China
    Chin Med J (Engl) 120:1597-605. 2007
  3. ncbi [Expression of pS2, TGF-alpha and PCNA in the gastric mucosa of young rats with endotoxemia]
    Chun Ying Liu
    Department of Pediatrics, 463 Hospital of Chinese People s Liberation Army, Shenyang 110042, China
    Zhongguo Dang Dai Er Ke Za Zhi 10:221-4. 2008
  4. pmc A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity
    Elizabeth A Heilig
    Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 285:22350-9. 2010
  5. doi 4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway
    Young Jung Lee
    College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361 763, Korea
    Free Radic Biol Med 50:66-77. 2011
  6. pmc Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease
    Bart De Strooper
    KULeuven and Flanders Interuniversitary Institute for Biotechnology VIB, Centre for Human Genetics, Herestraat 49, 3000 Leuven, Belgium
    EMBO Rep 8:141-6. 2007
  7. ncbi Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes
    Keiro Shirotani
    Munich Center for Integrated Protein Science and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, Schillerstr 44, Munich, Germany
    Neurobiol Dis 27:102-7. 2007
  8. ncbi Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
    J Li
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:917-27. 1997
  9. pmc Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
    Peter Mastrangelo
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 3H2
    Proc Natl Acad Sci U S A 102:8972-7. 2005
  10. ncbi Presenilin mutations in Alzheimer's disease
    M Cruts
    Flanders Interuniversity Institute for Biotechnology, BornBunge Foundation, University of Antwerp, Department of Biochemistry, Antwerpen, Belgium
    Hum Mutat 11:183-90. 1998

Research Grants

  1. Regeneration of Nucleus Pulposus by Tissue Engineering
    IRVING M contact SHAPIRO; Fiscal Year: 2010
  2. Modifiers of Beta-Amyloid Metabolism and Deposition
    Bruce T Lamb; Fiscal Year: 2010
  3. Alzheimre's disease antiamyloid neuroprotective tmt
    Bala Manyam; Fiscal Year: 2003
  4. PRESENILINS, APOPTOSIS AND AMYLOID BETA PROTEIN
    Joseph Buxbaum; Fiscal Year: 2003
  5. Plasma AB as a Surrogate Genetic Marker for LOAD
    Steven Younkin; Fiscal Year: 2009
  6. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2007
  7. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2009
  8. Prediction of Psychosis in Alzheimer Disease
    Robert A Sweet; Fiscal Year: 2010
  9. An Integrated Genomic Approach to Alzheimer Disease
    Margaret Pericak Vance; Fiscal Year: 2006
  10. MECHANISM OF PRESENILIN 1--ASSOCIATED CELL DEATH
    Rudolph Tanzi; Fiscal Year: 2001

Detail Information

Publications185 found, 100 shown here

  1. pmc Interaction of presenilins with the filamin family of actin-binding proteins
    W Zhang
    Department of Pediatrics and Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 18:914-22. 1998
    Mutations in presenilin genes PS1 and PS2 account for approximately 50% of early-onset familial Alzheimer's disease (FAD)...
  2. ncbi Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas
    Yun gang Zhang
    Department of Pathology, Peking University Health Science Center, Beijing, China
    Chin Med J (Engl) 120:1597-605. 2007
    ..breast carcinomas, and their associations with known clinicopathological parameters, tumor recurrence and expressions of estrogen receptor (ER), progesterone receptor (PR), PS2 and c-erbB2 were not well studied in Chinese patients.
  3. ncbi [Expression of pS2, TGF-alpha and PCNA in the gastric mucosa of young rats with endotoxemia]
    Chun Ying Liu
    Department of Pediatrics, 463 Hospital of Chinese People s Liberation Army, Shenyang 110042, China
    Zhongguo Dang Dai Er Ke Za Zhi 10:221-4. 2008
    ..This study aimed to investigate the effect of pS2, TGF-alpha and PCNA in endotoxin-induced acute gastric mucosal injury in young rats.
  4. pmc A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity
    Elizabeth A Heilig
    Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 285:22350-9. 2010
    Mutations in presenilin-1 and presenilin-2 (PS1 and PS2) are the most common cause of familial Alzheimer disease...
  5. doi 4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway
    Young Jung Lee
    College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361 763, Korea
    Free Radic Biol Med 50:66-77. 2011
    b>Presenilin 2 (PS2) mutation increases Aβ generation and neuronal cell death in the brains of Alzheimer disease (AD) patients...
  6. pmc Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease
    Bart De Strooper
    KULeuven and Flanders Interuniversitary Institute for Biotechnology VIB, Centre for Human Genetics, Herestraat 49, 3000 Leuven, Belgium
    EMBO Rep 8:141-6. 2007
    ..In this review, I evaluate the implications of this model for the amyloid-cascade hypothesis and for the efficacy of presenilin/gamma-secretase as a drug target...
  7. ncbi Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes
    Keiro Shirotani
    Munich Center for Integrated Protein Science and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, Schillerstr 44, Munich, Germany
    Neurobiol Dis 27:102-7. 2007
    ..complexes are active in APP processing and that all combinations of APH-1 variants with either FAD mutant PS1 or PS2 support pathogenic Abeta(42) production...
  8. ncbi Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
    J Li
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:917-27. 1997
    ..We discuss a pathogenic pathway for familial Alzheimer's disease in which defective presenilin function causes chromosome missegregation during mitosis, resulting in apoptosis and/or trisomy 21 mosaicism...
  9. pmc Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
    Peter Mastrangelo
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 3H2
    Proc Natl Acad Sci U S A 102:8972-7. 2005
    ..of amyloid-beta precursor protein (APP) and Notch, and familial Alzheimer's disease (FAD) mutations in PS1 or PS2 genes shift APP cleavage from production of amyloid-beta (Abeta) 40 peptide to greater production of Abeta42...
  10. ncbi Presenilin mutations in Alzheimer's disease
    M Cruts
    Flanders Interuniversity Institute for Biotechnology, BornBunge Foundation, University of Antwerp, Department of Biochemistry, Antwerpen, Belgium
    Hum Mutat 11:183-90. 1998
    ..In vivo and in vitro studies have linked PS mutations to amyloid deposition, an early pathological event in AD brains...
  11. pmc Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2
    Suman Jayadev
    Department of Neurology, University of Washington, 1660 S Columbian Way, 182 GRECC, Seattle, WA 98108, USA
    Brain 133:1143-54. 2010
    Mutations in presenilin 2 are rare causes of early onset familial Alzheimer's disease. Eighteen presenilin 2 mutations have been reported, although not all have been confirmed pathogenic...
  12. ncbi Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    E I Rogaev
    Department of Medicine Neurology, University of Toronto, Ontario, Canada
    Nature 376:775-8. 1995
    ..Our results also indicate that still other AD susceptibility genes exist...
  13. ncbi Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia
    D Arango
    Neuro Sciences Group, Instituto Nacional de Salud, Bogota, Colombia
    Am J Med Genet 103:138-43. 2001
    Nearly all mutations in the presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid beta precursor protein (APP) genes lead to early-onset Alzheimer disease (EOAD, onset age at or before 65 years)...
  14. ncbi Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3
    P Vito
    T Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Maryland 20892, USA
    J Biol Chem 271:31025-8. 1996
    ALG-3, a truncated mouse homologue of the chromosome 1 familial Alzheimer's disease gene PS2, rescues T hybridoma 3DO cells from T-cell receptor-induced apoptosis by inhibiting Fas ligand induction and Fas signaling...
  15. ncbi A mutation screening by DHPLC of PSEN1 and APP genes reveals no significant variation associated with the sporadic late-onset form of Alzheimer's disease
    Renato Scacchi
    CNR Institute of Molecular Biology and Pathology, c o Department of Genetics and Molecular Biology, University La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
    Neurosci Lett 418:282-5. 2007
    ..been reportedly caused by mutations in amyloid precursor protein (APP), presenilin-1 (PSEN1), or presenilin-2 (PSEN2) genes, whereas the genetic component for the sporadic form is less clear...
  16. ncbi Presenilin 2 Ser130Leu mutation in a case of late-onset "sporadic" Alzheimer's disease
    Carmine Tomaino
    J Neurol 254:391-3. 2007
  17. doi A novel Italian presenilin 2 gene mutation with prevalent behavioral phenotype
    Gabriella Marcon
    Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy
    J Alzheimers Dis 16:509-11. 2009
    ..far, more than 160 mutations in the Presenilin 1 gene (PSEN1) and approximately 10 mutations in the homologous Presenilin 2 gene (PSEN2) have been identified...
  18. ncbi Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment
    J D Buxbaum
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Med 4:1177-81. 1998
    ..Alzheimer disease (AD) cases are caused by mutations in the highly related genes presenilin 1 (PS1) and presenilin 2 (PS2)...
  19. pmc When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease
    Michael S Wolfe
    Center for Neurologic Diseases, Harvard Medical School, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Harvard Institute of Medicine 754, Boston, Massachusetts 02115, USA
    EMBO Rep 8:136-40. 2007
    ..In this review, a unifying hypothesis is presented that puts forward a biochemical mechanism by which slower less-efficient forms of the protease can result in a greater proportion of 42-residue Abeta...
  20. ncbi Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells
    D M Kovacs
    Genetics and Aging Unit, Massachusetts General Hospital East, Harvard Medical School, Charlestown 02129, USA
    Nat Med 2:224-9. 1996
    ..These two novel genes, presenilin 1 (PS1) and presenilin 2 (PS2) are members of an evolutionarily conserved gene family...
  21. ncbi Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease
    M Cruts
    Laboratory of Neurogenetics, Flanders Interuniversity Institute for Biotechnology VIB, Born Bunge Foundation BBS, University of Antwerp UIA, Department of Biochemistry, Antwerpen, Belgium
    Hum Mol Genet 7:43-51. 1998
    ..Further, polymorphisms were detected in the promoter and the 5'-non-coding region of PS -1 and in intronic and exonic sequences of PS -2 that will be useful in genetic association studies...
  22. pmc The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue
    T Tomita
    Laboratory of Neurochemistry, National Institute for Physiological Sciences, Okazaki, Japan
    Proc Natl Acad Sci U S A 94:2025-30. 1997
    ..in the pathogenetic mechanisms of early-onset familial Alzheimer disease (FAD), we expressed cDNAs for wild-type PS2 and PS2 with the Volga German (N141I) mutation in cultured cells and then examined the metabolism of the ..
  23. ncbi Presenilins are processed by caspase-type proteases
    H Loetscher
    Pharma Division, Preclinical Central Nervous System Research GeneTechnology, F Hoffmann La Roche Ltd, CH 4070 Basel, Switzerland
    J Biol Chem 272:20655-9. 1997
    Presenilin 1 (PS1) and presenilin 2 (PS2) are endoproteolytically processed in vivo and in cell transfectants to yield 27-35-kDa N-terminal and 15-24-kDa C-terminal fragments...
  24. ncbi Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling
    David E Kang
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 280:31537-47. 2005
    The Alzheimer's disease-linked genes, PS1 and PS2, are required for intramembrane proteolysis of multiple type I proteins, including Notch and amyloid precursor protein...
  25. ncbi Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
    T W Kim
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Science 277:373-6. 1997
    ..familial Alzheimer's disease (FAD) are caused by mutations in the genes encoding the presenilin 1 (PS1) and PS2 proteins, both of which undergo regulated endoproteolytic processing...
  26. pmc The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
    J Walter
    Central Institute of Mental Health, Department of Molecular Biology, Mannheim, Germany
    Mol Med 2:673-91. 1996
    ..Mutations in the recently cloned Presenilin genes (PS-1 and PS-2) are by far the most common cause of early onset familial AD...
  27. pmc A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein
    S M Stabler
    Medical Biotechnology Center and Department of Neurology, University of Maryland, Baltimore, Maryland 21201, USA
    J Cell Biol 145:1277-92. 1999
    ..We report here the identification of a calcium-binding protein, calmyrin, that interacts preferentially with presenilin 2 (PS2)...
  28. ncbi Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
    K Duff
    Suncoast Alzheimer s Disease Laboratories, University of South Florida, Tampa, 33612, USA
    Nature 383:710-3. 1996
    Mutations in the genes encoding amyloid-beta precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) are known to cause early-onset, autosomal dominant Alzheimer's disease...
  29. ncbi The presenilin 2 loop domain interacts with the mu-calpain C-terminal region
    K Shinozaki
    Laboratory of Neurochemistry, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444, Japan
    Int J Mol Med 1:797-9. 1998
    b>Presenilin 2 (PS2) is a gene responsible for the early-onset familial Alzheimer's disease (AD). PS2 mutations are considered to be closely related to the pathogenesis of AD...
  30. ncbi Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation
    B Wolozin
    Unit on Alzheimer Biology, Laboratory of Clinical Science, National Institute of Mental Health, Building 10, Room 3D41, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Science 274:1710-3. 1996
    Overexpression of the familial Alzheimer's disease gene Presenilin 2 (PS2) in nerve growth factor-differentiated PC12 cells increased apoptosis induced by trophic factor withdrawal or beta-amyloid...
  31. ncbi A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis
    Suzuka Ataka
    Department of Neurology, Osaka City University Medical School, Osaka, Japan
    Arch Neurol 61:1773-6. 2004
    ..disease is caused by mutations in the amyloid precursor protein (APP), presenilin-1 (PSEN1), or presenilin-2 (PSEN2) genes. Phenotypic diversity has been reported to be associated with various mutations in PSEN1...
  32. ncbi A pedigree with a novel presenilin 1 mutation at a residue that is not conserved in presenilin 2
    M Yasuda
    Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Arch Neurol 56:65-9. 1999
    ..To disclose a novel mutation of the presenilin 1 (PS1) gene responsible for early-onset Alzheimer disease and to clarify genotype-phenotype correlation that should help to establish the function of this protein...
  33. ncbi Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12
    M A Pericak-Vance
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 278:1237-41. 1997
    ..have been identified as contributing to Alzheimer disease (AD), including the amyloid precursor protein gene, the presenilin 1 gene, the presenilin 2 gene, and the apolipoprotein E gene, but do not account for all the genetic risk for AD.
  34. ncbi Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene
    J R Murrell
    Department of Pathology and Laboratory Medicine, 635 Barnhill Dr, Medical Science Bldg A128, Indianapolis, IN 46202, USA
    Arch Neurol 57:885-7. 2000
    Alzheimer disease is the most common form of dementia. Mutations in the genes amyloid precursor protein (APP), presenilin 1(PS1) and presenilin 2(PS2) have been found in early-onset familial forms of Alzheimer disease
  35. ncbi Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease
    H Steiner
    Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Dept. of Biochemistry, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 249:266-70. 1999
    ..Like the mutations identified within the betaAPP gene, mutations in PS1 and PS2 cause the increased generation of Abeta42...
  36. pmc Identification and characterization of Tc1/mariner-like DNA transposons in genomes of the pathogenic fungi of the Paracoccidioides species complex
    Marjorie M Marini
    Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    BMC Genomics 11:130. 2010
    ..In this study the identification and characterization of class II transposable elements in the genomes of these fungi was carried out...
  37. ncbi The genetics of very early onset Alzheimer disease
    Christopher M Filley
    Department of Neurology, University of Colorado School of Medicine, Denver, CO, USA
    Cogn Behav Neurol 20:149-56. 2007
    ..This study was undertaken to clarify the genetics of very early onset Alzheimer disease (VEOAD), defined as AD beginning before age 35...
  38. doi Pharmacogenomics and therapeutic prospects in dementia
    Ramon Cacabelos
    EuroEspes Biomedical Research Center, Institute for CNS Disorders, 15166 Bergondo, Coruna, Spain
    Eur Arch Psychiatry Clin Neurosci 258:28-47. 2008
    ..Mutations in genes directly associated with the amyloid cascade (APP, PS1, PS2) are only present in less than 5% of the AD population; however, the presence of the APOE-4 allele in the ..
  39. ncbi Recruitment of distinct chromatin-modifying complexes by tamoxifen-complexed estrogen receptor at natural target gene promoters in vivo
    Xue Feng Liu
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 279:15050-8. 2004
    ..we observed that treatment with OHT rapidly induces the binding of ERalpha to the E-responsive promoter regions of pS2 and c-myc genes...
  40. ncbi Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
    Ming Tain Lai
    Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 278:22475-81. 2003
    Presenilin-1 (PS1) and presenilin 2 (PS2) are proposed to be transmembrane aspartyl proteases that cleave amyloid precursor protein and Notch...
  41. ncbi Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain
    F Oyama
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan
    J Neurochem 71:313-22. 1998
    ..We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken beta-actin promoter...
  42. pmc Polymorphism in the flanking regions of the PbGP43 gene from the human pathogen Paracoccidioides brasiliensis: search for protein binding sequences and poly(A) cleavage sites
    Antonio A Rocha
    Department of Microbiology, Federal University of Sao Paulo, Sao Paulo, Brazil
    BMC Microbiol 9:277. 2009
    ..It is structurally related to glucanases, however not active, and whose expression varies considerably. We have presently studied polymorphisms in the PbGP43 flanking regions to help understand such variations...
  43. ncbi Immune responses and latent herpesvirus reactivation in spaceflight
    R P Stowe
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0609, USA
    Aviat Space Environ Med 72:884-91. 2001
    ..In addition, adrenocortical and immune responses of an elderly astronaut (payload specialist-2, PS2; age 77) who flew on this mission were compared with that of younger crewmembers.
  44. ncbi Modulation of the estrogen-regulated proteins cathepsin D and pS2 by opioid agonists in hormone-sensitive breast cancer cell lines (MCF7 and T47D): evidence for an interaction between the two systems
    S Panagiotou
    Laboratoire de Cancerologie Experimentale, CJF INSERM 93 11, Marseille, France
    J Cell Biochem 71:416-28. 1998
    ..To investigate this interaction, we have assayed two estrogen-inducible proteins (pS2 and the lysosomal enzyme cathepsin D) in MCF7 and T47D cells...
  45. doi Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades
    C J Carter
    Neurochem Int 52:920-34. 2008
    ..A2M), and enters cells via nectin receptors, which are cleaved by gamma-secretase (APH1B, PSEN1, PSEN2, PEN2, NCSTN)...
  46. ncbi Heterogeneous origin of carbonic anhydrase activity of thylakoid membranes
    L K Ignatova
    Institute of Basic Biological Problems, Russian Academy of Sciences, 142290 Pushchino, Russia
    Biochemistry (Mosc) 71:525-32. 2006
    ..of pea thylakoids as well as thylakoid fragments enriched either in Photosystem 1 (PS1-membranes) or Photosystem 2 (PS2-membranes) were studied...
  47. ncbi The function of presenilin-1 in amyloid beta-peptide generation and brain development
    P Saftig
    Zentrum Biochemie und Molekulare Zellbiologie, Abteilung Biochemie II, , Germany
    Eur Arch Psychiatry Clin Neurosci 249:271-9. 1999
    ..All mutations in the three FAD genes, i.e., amyloid precursor protein (APP), presenilin 1 (PS-1), and presenilin 2 (PS-2) cause an increased production of a longer, more amyloidogenic form of the amyloid peptide corroborating ..
  48. pmc Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1
    Leslie A Rudzinski
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Alzheimer Dis Assoc Disord 22:299-307. 2008
    ..disease (EOFAD) can be caused by mutations in genes for amyloid precursor protein, presenilin 1 (PSEN1), or presenilin 2 (PSEN2)...
  49. ncbi Drosophila PS integrins recognize vertebrate vitronectin and function as cell-substratum adhesion receptors in vitro
    S Hirano
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 113:1007-16. 1991
    ..The other components immunoprecipitated included two alpha chains of Drosophila integrins, PS1 alpha and PS2 alpha, as revealed using specific antibodies to these molecules...
  50. doi Lead(II)-induced allosteric G-quadruplex DNAzyme as a colorimetric and chemiluminescence sensor for highly sensitive and selective Pb2+ detection
    Tao Li
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, People s Republic of China
    Anal Chem 82:1515-20. 2010
    ..Here, we choose a common G-quadruplex DNAzyme named PS2.M to develop a novel Pb(2+) sensor with two detection means: colorimetry and chemiluminescence (CL)...
  51. ncbi Expression of the breast cancer-associated protein pS2 in adenosquamous carcinomas of the gastrointestinal tract
    C Welter
    , , Homburg/Saar, Germany
    Acta Oncol 32:315-7. 1993
    The breast cancer-associated protein pS2 is also present in many human gastrointestinal tumors...
  52. ncbi Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
    Jos Tournoy
    Neuronal Cell Biology Laboratory, Center for Human Genetics CB 4, University Hospital, Catholic University of Leuven, Belgium
    Hum Mol Genet 13:1321-31. 2004
    Presenilin (PS1) and (PS2) are the centers of gamma-secretase that release Abeta from APP in Alzheimer's disease (AD). They cleave signaling proteins like Notch and downregulate beta-catenin to modulate Wnt signaling...
  53. ncbi Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide
    K Yamamoto
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
    J Immunol 140:311-7. 1988
    A cloned complementary DNA, termed pS2, was isolated from a human fibroblast cDNA library in the bacteriophage expression vector lambda gt11 after screening with a patient's serum containing a high titer of anti-ribonucleoprotein (RNP) ..
  54. ncbi Alzheimer's disease pathogenesis and therapeutic interventions
    M S Parihar
    Neuroscience Laboratory, Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield, IL 62794 9626, USA
    J Clin Neurosci 11:456-67. 2004
    ..These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE)...
  55. pmc Time at surgery during menstrual cycle and menopause affects pS2 but not cathepsin D levels in breast cancer
    P Pujol
    Service de Biologie Cellulaire, , France
    Br J Cancer 79:909-14. 1999
    Many studies have addressed the clinical value of pS2 as a marker of hormone responsiveness and of cathepsin D (Cath D) as a prognostic factor in breast cancer...
  56. pmc Outer membrane proteins of Fibrobacter succinogenes with potential roles in adhesion to cellulose and in cellulose digestion
    Hyun Sik Jun
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada
    J Bacteriol 189:6806-15. 2007
    ..of binding of intact glucose-grown Fibrobacter succinogenes strain S85 cells and adhesion-defective mutants AD1 and AD4 to crystalline and acid-swollen (amorphous) cellulose showed that strain S85 bound efficiently to both forms of ..
  57. ncbi Transcriptional regulation of the human FTZ-F1 gene encoding Ad4BP/SF-1
    K Oba
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi Higashi-ku, Fukuoka 812-8582, Japan
    J Biochem 128:517-28. 2000
    ..FTZ-F1 genes, and a possible autoregulatory mechanism of the rFTZ-F1 gene by Ad4BP itself through binding to the Ad4 (or SF-1) site in the first intron...
  58. ncbi The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments
    T Bogaert
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 51:929-40. 1987
    We establish that the position-specific antigen 2 (PS2), a Drosophila cell surface glycoprotein complex, is an invertebrate member of the vertebrate fibronectin receptor (integrin) family...
  59. ncbi [Anti-complement activity of polysaccharide B3-PS2 purified from Herba Scutellariae Barbatae]
    Yan Wu
    The Life Science Department of Anqing Normal College, Anqing 246011, China
    Yao Xue Xue Bao 44:615-9. 2009
    The polysaccharide B3-PS2 was extracted and purified from Herba Scutellariae Barbatae through chromatography of DEAE-cellulose and Sephacryl S-300 column. Average molecular weight of B3-PS2 was about 1,100 kD...
  60. ncbi The surface (S)-layer gene cspB of Corynebacterium glutamicum is transcriptionally activated by a LuxR-type regulator and located on a 6 kb genomic island absent from the type strain ATCC 13032
    Nicole Hansmeier
    Lehrstuhl fur Genetik, Fakultat fur Biologie, Universitat Bielefeld, Universitatsstrasse 25, D 33615 Bielefeld, Germany
    Microbiology 152:923-35. 2006
    ..This region includes cspB, the structural gene encoding the S-layer protomer PS2, and six additional coding sequences...
  61. doi Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection
    Guo dong Huang
    Department of Integrative Medicine, The First Affiliated Hospital of Nanchang University, Nangchang, 330066, China
    Chin J Integr Med 14:23-7. 2008
    To observe the effect of volatile oil of amomum (VOA) on the expressions of mastocarcinoma-related peptide (PS2) and platelet activating factor (PAF) in helicobacter pyloriassociated gastritis (HPG) and to analyze its potential mechanism.
  62. ncbi Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model
    Marjoke Heneweer
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 83:257-63. 2005
    ..RNA was isolated and reverse-transcriptase polymerase chain reaction (RT-PCR) was performed on the aromatase and pS2 genes...
  63. ncbi Additive estrogenic effects of mixtures of frequently used UV filters on pS2-gene transcription in MCF-7 cells
    Marjoke Heneweer
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
    Toxicol Appl Pharmacol 208:170-7. 2005
    ..In this paper, estrogen-regulated pS2 gene transcription in the human mammary tumor cell line MCF-7 was used as a measure of estrogenicity of four ..
  64. ncbi Photoinhibition and recovery of photosynthesis in leaves of Vitis berlandieri and Vitis rupestris
    Massimo Bertamini
    Istituto Agrario di San Michele all Adige, 38010 San Michele all Adige, Italy
    J Plant Physiol 161:203-10. 2004
    ..The potential efficiency of PS2, Fv/Fm declined, Fo increased significantly in leaves of V. berlandieri, while Fo decreased in V. rupestris...
  65. ncbi Response of crypt paneth cells in the small intestine following total-body gamma-irradiation
    N V Gorbunov
    The Henry M Jackson Foundation for the Advancement of Military Medicine, Inc, USA
    Int J Immunopathol Pharmacol 23:1111-23. 2010
    ..we assessed the irradiation response of crypt host-defense Paneth cells by measuring alpha-defensin 4 (AD4) expression and correlated the gathered data with activation of the caspase-1/IL-1β inflammatory signaling cascade...
  66. ncbi Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer
    E Ioachim
    Department of Pathology, Medical School, University of Ioannina, Greece
    Breast 12:111-9. 2003
    Expression of the hormone-related proteins hsp27, pS2, and also of cathepsin D (CD) and metallothionein (MT) was studied by immunohistochemistry and analyzed against clinical data in breast cancer...
  67. doi pS2 (TFF1) expression in prostate carcinoma: correlation with steroid receptor status
    Asmaa Gaber Abdou
    Department of Pathology, Faculty of Medicine, Menofiya University, Shebein Elkom, Egypt
    APMIS 116:961-71. 2008
    b>pS2 or TFF1 is a member of the trefoil factor family, which is distributed throughout the gastrointestinal tract in both normal and diseased tissues...
  68. ncbi Biochemical properties of endogenous presenilin 1 and presenilin 2 in cultured human B-lymphocytes
    Lukasz Bojarski
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland
    Clin Chem Lab Med 45:1273-6. 2007
    Presenilin 1 (PS1) and presenilin 2 (PS2) are membranous proteins involved in the pathology of Alzheimer's disease...
  69. ncbi Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters
    Jason Matthews
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge 14157, Sweden
    Mol Endocrinol 20:534-43. 2006
    ..Real-time PCR analysis of mRNA levels of two well-studied estrogen-responsive genes, pS2 and progesterone receptor (PR), showed that the expression levels of both genes were reduced in the presence of ..
  70. ncbi Effect of steroid receptors, pS2 and cathepsin D on the outcome of elderly breast cancer patients: an exploratory investigation
    D Coradini
    Division of Experimental Oncology C, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Int J Cancer 79:305-11. 1998
    In 83 elderly breast cancer patients, oestrogen and progesterone receptors (ER, PgR), pS2 and cathepsin D (CathD) were evaluated for their possible prognostic role on disease-free survival (DFS)...
  71. ncbi Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus
    C Apert
    INSERM U159, Centre Paul Broca, Paris, France
    J Neuroendocrinol 10:101-9. 1998
    ..pattern of APP moeities in mouse hypothalamus and in fetal hypothalamic neurons in culture was compared with a presenilin 2 (PS2) related protein using an antibody developed against the N-terminal part of PS2...
  72. ncbi Effect of a carotene concentrate on the growth of human breast cancer cells and pS2 gene expression
    K Nesaretnam
    Palm Oil Research Institute of Malaysia, 6 Persiaran Institusi, Bandar Baru Bangi, 43000, Kajang, Malaysia
    Toxicology 151:117-26. 2000
    ..The pS2 gene is an estrogen-regulated gene and serves as a marker for the ER+ tumours...
  73. ncbi Specific downregulation of presenilin 2 gene expression is prominent during early stages of sporadic late-onset Alzheimer's disease
    P J McMillan
    Department of Psychiatry and Behavioral Sciences, Box 356560, University of Washington, Seattle, WA 98195, USA
    Brain Res Mol Brain Res 78:138-45. 2000
    Mutations in the presenilin genes PS1 and PS2 cause familial Alzheimer's disease (AD)...
  74. pmc PS2 in breast cancer--alternative or complementary tool to steroid receptor status? Evaluation of 446 cases
    M Gion
    Center for the Study of Biological Markers of Malignancy, General Regional Hospital, Venice, Italy
    Br J Cancer 68:374-9. 1993
    The oestrogen induced pS2 protein was measured in the cytosol of 446 breast cancer samples by an immunoradiometric assay. The relationships between pS2 and several clinical and biological parameters were evaluated...
  75. pmc Primary charge separation in the photosystem II core from Synechocystis: a comparison of femtosecond visible/midinfrared pump-probe spectra of wild-type and two P680 mutants
    Mariangela Di Donato
    Department of Physics, Free University Amsterdam, Amsterdam, The Netherlands
    Biophys J 94:4783-95. 2008
    It is now quite well accepted that charge separation in PS2 reaction centers starts predominantly from the accessory chlorophyll B(A) and not from the special pair P(680)...
  76. ncbi Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos
    A Prokop
    Department of Zoology, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 196:58-76. 1998
    ..junctions ultrastructurally in single or double mutant Drosophila embryos lacking PS1 integrin (alphaPS1betaPS), PS2 integrin (alphaPS2betaPS), and/or their potential extracellular ligand laminin A...
  77. doi Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase
    Ingvild S Fenne
    Institute of Medicine, Section for Endocrinology, University of Bergen, Bergen, Norway
    Endocrinology 149:4336-45. 2008
    ..cAMP/PKA initiated a rapid recruitment of GRIP1 to the endogenous estrogen receptor (ER)-alpha target pS2 gene promoter...
  78. ncbi Interplay between estrogen response element sequence and ligands controls in vivo binding of estrogen receptor to regulated genes
    Adam J Krieg
    Department of Biochemistry, University of Illinois, Urbana, Illinois 61801 3602, USA
    J Biol Chem 279:5025-34. 2004
    ..estrogen receptor (ER) to promoters, we analyzed in vivo interaction of liganded ER with the imperfect ERE in the pS2 gene and the composite estrogen-responsive unit (ERU) in the proteinase inhibitor 9 (PI-9) gene...
  79. ncbi Constitutive and cytokine-regulated expression of presenilin-1 and presenilin-2 genes in human neural cell lines
    J Satoh
    Division of Neurology, Department of Internal Medicine, Saga Medical School, Saga, Japan
    Neuropathol Appl Neurobiol 25:492-503. 1999
    ..the regulation of presenilin (PS) gene expression in human neural cells, both presenilin-1 (PS1) and presenilin-2 (PS2) mRNA levels were analysed by Northern blotting in SK-N-SH neuroblastoma, IMR-32 neuroblastoma, NTera2 ..
  80. pmc Expression of pS2 in prostate cancer correlates with grade and Chromogranin A expression but not with stage
    M Hammad Ather
    Dept of Surgery, Aga Khan University, Karachi, Pakistan
    BMC Urol 4:14. 2004
    ..Particular interest is focused on markers not expressed in normal prostatic tissues. pS2 protein expression has been demonstrated in a range of malignant tissues in an oestrogen-independent pathway...
  81. ncbi Effect of antibody against integrin alpha4 on bleomycin-induced pulmonary fibrosis in mice
    Q Wang
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Biochem Pharmacol 60:1949-58. 2000
    ..In this study, we tested the hypothesis that neutralizing antibody for integrin alpha4 (PS2) may reduce bleomycin (BL)-induced lung fibrosis in vivo...
  82. ncbi Gene regulation in an MCF-7 cell line that naturally expresses an estrogen receptor unable to directly bind DNA
    Brian T Pentecost
    Wadsworth Center, NY State DoH, P O Box 509, Albany, NY 12201 0509, USA
    Mol Cell Endocrinol 238:9-25. 2005
    ..The E2-induction of progesterone receptor (PR) and HEM45 mRNAs was abolished. The effect on pS2 mRNA expression was complex: the pS2 mRNA levels fell approximately 50-fold in control M-ERd3/g8 cells...
  83. doi Transmembrane electric potential difference in the protein-pigment complex of photosystem 2
    M D Mamedov
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
    Biochemistry (Mosc) 77:947-55. 2012
    The protein-pigment complex of photosystem 2 (PS2) localized in the thylakoid membranes of higher plants, algae, and cyanobacteria is the main source of oxygen on Earth...
  84. pmc RNAi-mediated inhibition of presenilin 2 inhibits glioma cell growth and invasion and is involved in the regulation of Nrg1/ErbB signaling
    Bei Liu
    Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, Xi an, People s Republic of China
    Neuro Oncol 14:994-1006. 2012
    ..In this study, we found that the protein expression of presenilin 2 (PS2) was significantly increased in glioma tissues, at least partially because of promoter demethylation...
  85. ncbi Using spectroscopic and microscopic methods to probe the structural stability of human adenovirus type 4
    Feng He
    Laboratory for Macromolecular and Vaccine Stabilization, Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA
    Hum Vaccin 6:202-11. 2010
    ..a decrease in Ad4 stability as pH increases from 4 to 8, similar to the behavior reported previously for Ad2 and Ad5, although the Ad4 virion appears to possess slightly more tolerance to thermal stress...
  86. doi Randomized phase III trial of gemcitabine and cisplatin vs. gemcitabine alone in patients with advanced non-small cell lung cancer and a performance status of 2: the CAPPA-2 study
    Alessandro Morabito
    National Cancer Institute, G Pascale, Foundation, Via M Semmola, 80131 Napoli, Italy
    Lung Cancer 81:77-83. 2013
    ..trial has tested the addition of cisplatin to single-agent chemotherapy in patients with advanced NSCLC and PS2. CAPPA-2 was a multicenter, randomized phase 3 study for first-line treatment of PS2 patients with advanced NSCLC...
  87. pmc A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2
    Xulun Zhang
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 32:8633-48. 2012
    Presenilins 1 and 2 (PS1 and PS2) are the catalytic subunits of the γ-secretase complex, and genes encoding mutant PS1 and PS2 variants cause familial forms of Alzheimer's disease. Lee et al...
  88. doi Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients
    Ebba Lohmann
    Department of Neurology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Neurobiol Aging 33:1850.e17-27. 2012
    ..disease causative genes in Turkish dementia patients we screened amyloid precursor protein (APP), PSEN1 and PSEN2 for mutations in a cohort of 98 Turkish dementia families. Six families were found to carry PSEN1 mutations (p...
  89. doi The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease
    Amy Gerrish
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
    J Alzheimers Dis 28:377-87. 2012
    Rare mutations in AβPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders...
  90. pmc Modulation of transient receptor potential melastatin related 7 channel by presenilins
    Hyun Geun Oh
    Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440 746, South Korea
    Dev Neurobiol 72:865-77. 2012
    Presenilins (PS1 and PS2) are multifunctional proteins involved in a diverse array of molecular and cellular functions, including proteolysis, development, neurogenesis, synaptic plasticity, ion channel regulation and phospholipid ..
  91. ncbi Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues
    M K Lee
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 16:7513-25. 1996
    Mutations in genes encoding related proteins, termed presenilin 1 (PS1) and presenilin 2 (PS2), are linked to the majority of cases with early-onset familial Alzheimer's disease (FAD)...
  92. ncbi Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1
    A Parent
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neurobiol Dis 6:56-62. 1999
    Mutations in two related genes, presenilin 1 and presenilin 2 (PS1 and PS2), cause a subset of early-onset familial Alzheimer's disease (FAD)...
  93. ncbi SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1
    Sabine Wagner
    Institute of Molecular Biology and Tumor Research IMT, Philipps University of Marburg, Emil Mannkopff Strasse 2, 35032 Marburg, Germany
    J Biol Chem 281:27242-50. 2006
    ..We show here that endogenous PRMT1 is a crucial and non-redundant coactivator of ER-mediated pS2 gene induction in MCF7 cells...
  94. ncbi pS2 in breast carcinoma: association with steroid hormone receptor status
    D Nikolic-Vukosavljevic
    Institute of Oncology and Radiology of Serbia, Belgrade, Yugoslavia
    Tumori 84:691-4. 1998
    ..In the present study the possible importance of estrogen-regulated pS2 protein was investigated...
  95. ncbi Implications of presenilin 1 mutations in Alzheimer's disease
    H Komano
    Department of Dementia Research, National Institute for Longevity Sciences, Aichi, Japan
    Mech Ageing Dev 107:281-98. 1999
    Mutations in presenilin 1 (PS1) and presenilin 2 (PS2) are the most common genetic factors underlying the development of early-onset familial Alzheimer's disease (FAD)...
  96. ncbi Estrogen-regulated cut-off values of pS2 and cathepsin D expression in breast carcinomas
    Milan Markićević
    Laboratory for Receptors, Department of Experimental Oncology, Institute of Oncology and Radiology of Serbia, Serbia, Yugoslavia
    Adv Exp Med Biol 617:341-8. 2008
    The purpose of the study was to asses the expression of estrogen-induced pS2 and cathepsin D (CD) that might facilitate biological subgrouping of patients with breast carcinomas (BC) and its potential applicability in clinical oncology...
  97. ncbi Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease
    Dae Y Hwang
    Division of Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, 5 Nokbun dong Eunpyng ku, 122 704, Seoul, Korea
    Neurochem Res 30:1009-19. 2005
    ..Thus, the results indicate that SelM might play a suppressive or protective role in the pathology of patients with AD and it will be necessary to investigate further on functional roles of other up- and down-regulated gene in future...
  98. pmc Genetic analysis of the Drosophila alphaPS2 integrin subunit reveals discrete adhesive, morphogenetic and sarcomeric functions
    J W Bloor
    Wellcome CRC Institute, Cambridge, United Kingdom
    Genetics 148:1127-42. 1998
    ..forms at least two integrins by association with different alpha subunits: alphaPS1betaPS (PS1) and alphaPS2betaPS (PS2)...
  99. ncbi Localisation of presenilin 2 in human and rodent pancreatic islet beta-cells; Met239Val presenilin 2 variant is not associated with diabetes in man
    E T Jaikaran
    Diabetes Research Laboratories and Department of Human Anatomy and Genetics, Oxford, UK
    J Cell Sci 112:2137-44. 1999
    ..b>Presenilin 2 mRNA is expressed in brain, muscle and pancreas but the role of pancreatic presenilin 2 and its relationship to ..
  100. ncbi The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors
    T Gomez-Isla
    Neurology Service, Massachusetts General Hospital, Neurology Service, Brigham and Women s Hospital, Boston, USA
    Brain 122:1709-19. 1999
    To assess the influence of the presenilin 1 (PS1) and 2 (PS2) mutations on amyloid deposition, neurofibrillary tangle (NFT) formation and neuronal loss, we performed stereologically based counts in a high-order association cortex, the ..

Research Grants68

  1. Regeneration of Nucleus Pulposus by Tissue Engineering
    IRVING M contact SHAPIRO; Fiscal Year: 2010
    ..We will inject rabbit intervertebral discs with lentivirus encoding psen1/psen2-SiRNA to suppress expression of endogenous notch activity...
  2. Modifiers of Beta-Amyloid Metabolism and Deposition
    Bruce T Lamb; Fiscal Year: 2010
    ..altered dosage and mutations in the amyloid precursor protein gene as well as mutations in presenilin 1 and presenilin 2 genes all cause early-onset AD, while the APOE gene is major risk factor in late-onset AD...
  3. Alzheimre's disease antiamyloid neuroprotective tmt
    Bala Manyam; Fiscal Year: 2003
    ..with mutations in all three genes linked to early onset AD, the amyloid precursor protein, Presenilin 1 and Presenilin 2. Doubly transgenic mice with mutations in the amyloid precursor protein and Presenilin 1 rapidly develop AD-..
  4. PRESENILINS, APOPTOSIS AND AMYLOID BETA PROTEIN
    Joseph Buxbaum; Fiscal Year: 2003
    ..are caused by mutations in the highly related genes presenilin-1 (PS1) and presenilin-2 (PS1) and presinilin-2 (PS2) which encode what are predicted to be integral membrane proteins with six or eight membrane spanning domains...
  5. Plasma AB as a Surrogate Genetic Marker for LOAD
    Steven Younkin; Fiscal Year: 2009
    ..in conserved regions of major genes in the AB processing pathway (SORL1, APP, IDE, MME, ECE1, PLAU, BACE1, PSEN1, PSEN2, and VR22), and (3) evaluate the functional effects of the susceptibility alleles identified in specific aim 2...
  6. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2007
    ..Single locus and haplotype associations of NRG1, DTNBP1, DISC1, COMT, DAOA (formerly G72), AKT1, RGS4, APP, PS1, PS2, and MAPI with AD+P will be tested in a large (N=1000) AD+P vs AD-P Case-Control Cohort...
  7. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2009
    ..Single locus and haplotype associations of NRG1, DTNBP1, DISC1, COMT, DAOA (formerly G72), AKT1, RGS4, APP, PS1, PS2, and MAPI with AD+P will be tested in a large (N=1000) AD+P vs AD-P Case-Control Cohort...
  8. Prediction of Psychosis in Alzheimer Disease
    Robert A Sweet; Fiscal Year: 2010
    ..Single locus and haplotype associations of NRG1, DTNBP1, DISC1, COMT, DAOA (formerly G72), AKT1, RGS4, APP, PS1, PS2, and MAPI with AD+P will be tested in a large (N=1000) AD+P vs AD-P Case-Control Cohort...
  9. An Integrated Genomic Approach to Alzheimer Disease
    Margaret Pericak Vance; Fiscal Year: 2006
    ..Identifying the risks associated with the amyloid precursor protein, presenilin 1, presenilin 2, and apolipoprotein E genes has opened new avenues of research but because AD is a complex genetic disorder our ..
  10. MECHANISM OF PRESENILIN 1--ASSOCIATED CELL DEATH
    Rudolph Tanzi; Fiscal Year: 2001
    ..applicant's abstract) The genes encoding the amyloid beta protein precursor (APP) and presenilins 1 and 2 (PS1 and PS2) have been shown to harbor autosomal dominant gene defects in approximately 50 % of early-onset (<60 years) ..
  11. Biology of Breast Cancers Arising in Older Women
    Christopher Benz; Fiscal Year: 2007
    ..g. PR, pS2, Bcl2) and associated with enhanced oxidant stress-activated signaling (P-Erk5) and transcription factor ..
  12. Nipple Fluid Hormone Levels and Breast Cancer Risk
    SEEMA AHSAN KHAN; Fiscal Year: 2010
    ..dehydroepiandrosterone and testosterone) and related proteins (epidermal growth factor, cathepsin D, pS2, and prostate specific antigen)...
  13. Nipple Fluid Hormone Levels and Breast Cancer Risk
    Seema Khan; Fiscal Year: 2007
    ..dehydroepiandrosterone and testosterone) and related proteins (epidermal growth factor, cathepsin D, pS2, and prostate specific antigen)...
  14. GENOMIC SEARCH FOR SUSCEPTIBILITY--ALZHEIMER DISEASE
    Alison Goate; Fiscal Year: 2002
    ..protein precursor (APP) gene on chromosome 21, the presenilin 1 (PS-1) gene on chromosome 14 and the presenilin 2 (PS-2) gene on chromosome 1 (1-3)...
  15. Regeneration of Nucleus Pulposus by Tissue Engineering
    Irving Shapiro; Fiscal Year: 2009
    ..We will inject rabbit intervertebral discs with lentivirus encoding psen1/psen2-SiRNA to suppress expression of endogenous notch activity...
  16. Function of intramembrane aspartic protease
    Evgeny I Rogaev; Fiscal Year: 2010
    ..Mutations in two homologous presenilin genes, PS1 and PS2, are the cause of familial Alzheimer's disease (AD)...
  17. Plasma AB as a Surrogate Genetic Marker for LOAD
    Steven G Younkin; Fiscal Year: 2010
    ..in conserved regions of major genes in the AB processing pathway (SORL1, APP, IDE, MME, ECE1, PLAU, BACE1, PSEN1, PSEN2, and VR22), and (3) evaluate the functional effects of the susceptibility alleles identified in specific aim 2...
  18. Function of intramembrane aspartic protease
    Evgeny Rogaev; Fiscal Year: 2009
    ..Mutations in two homologous presenilin genes, PS1 and PS2, are the cause of familial Alzheimer's disease (AD)...