Genomes and Genes
Gene Symbol: PSD2
Description: pleckstrin and Sec7 domain containing 2
Alias: EFA6C, PH and SEC7 domain-containing protein 2, exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C, exchange factor for ARF6 C, pleckstrin homology and SEC7 domain-containing protein 2
- Gulshan K, Shahi P, Moye Rowley W. Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance. Mol Biol Cell. 2010;21:443-55 pubmed publisher..Saccharomyces cerevisiae has two different phosphatidylserine decarboxylase enzymes (Psd1 and Psd2) that catalyze formation of phosphatidylethanolamine...
- Kawałek A, Jagadeesan C, van der Klei I. Impaired biosynthesis of the non-bilayer lipids phosphatidylethanolamine or cardiolipin does not affect peroxisome biogenesis and proliferation in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2016;480:228-233 pubmed publisher..Analysis of strains deficient in one of the three PE biosynthesis pathways (psd1, psd2 or the triple deletion strain eki1 cki1 dpl1) revealed that in all three strains peroxisome numbers were reduced ..
- Kunkle B, Vardarajan B, Naj A, Whitehead P, Rolati S, Slifer S, et al. Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport. JAMA Neurol. 2017;74:1113-1122 pubmed publisher..6) years; and of the 7001 NHW controls, 4215 (60.2%) were women and mean (SD) age was 77.4 (8.6) years. The gene PSD2, for which multiple unrelated NHW cases had rare missense variants, was significantly associated with EOAD (P = ..
- Yu L, Dawe R, Boyle P, Gaiteri C, Yang J, Buchman A, et al. Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017;74:1473-1480 pubmed publisher..4 (6.0) years. Four co-expressed genes (PADI2 [Ensembl ENSG00000117115], ZNF385A [Ensembl ENSG00000161642], PSD2 [Ensembl ENSG00000146005], and A2ML1 [Ensembl ENSG00000166535]) were identified, of which higher expressions were ..