Gene Symbol: PSD2
Description: pleckstrin and Sec7 domain containing 2
Alias: EFA6C, PH and SEC7 domain-containing protein 2, exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C, exchange factor for ARF6 C, pleckstrin homology and SEC7 domain-containing protein 2
Species: human
Products:     PSD2

Top Publications

  1. Amaral V, Fernandes C, Felício M, Valle A, Quintana P, Almeida C, et al. Psd2 pea defensin shows a preference for mimetic membrane rafts enriched with glucosylceramide and ergosterol. Biochim Biophys Acta Biomembr. 2019;1861:713-728 pubmed publisher
    b>Psd2 is a pea defensin with 47 amino acid residues that inhibits the growth of fungal species by an uncharacterized mechanism...
  2. Vigié P, Cougouilles E, Bhatia Kiššová I, Salin B, Blancard C, Camougrand N. The mitochondrial phosphatidylserine decarboxylase Psd1 is involved in nitrogen starvation-induced mitophagy in yeast. J Cell Sci. 2019;132: pubmed publisher
    ..phosphatidylserine decarboxylase, is involved in mitophagy induction only after nitrogen starvation, whereas Psd2, which is located in vacuole, Golgi and endosome membranes, is required preferentially for mitophagy induction in ..
  3. Khandelwal N, Sarkar P, Gaur N, Chattopadhyay A, Prasad R. Phosphatidylserine decarboxylase governs plasma membrane fluidity and impacts drug susceptibilities of Candida albicans cells. Biochim Biophys Acta Biomembr. 2018;1860:2308-2319 pubmed publisher
    ..PSD1 and PSD2 genes encode phosphatidylserine decarboxylase which converts phosphatidylserine (PS) into PE in C. albicans cells...
  4. Davis S, Tams R, Solis N, Wagner A, Chen T, Jackson J, et al. Candida albicans cannot acquire sufficient ethanolamine from the host to support virulence in the absence of de novo phosphatidylethanolamine synthesis. Infect Immun. 2018;: pubmed publisher
    ..mutants for phosphatidylserine (PS) synthase (cho1ΔΔ) and PS decarboxylase (psd1ΔΔ psd2ΔΔ) are compromised for virulence in mouse models of systemic infection and oropharyngeal Candidiasis (OPC)...
  5. Wolf J, Espadas J, Luque Garcia J, REYNOLDS T, Casadevall A. Lipid Biosynthetic Genes Affect Candida albicans Extracellular Vesicle Morphology, Cargo, and Immunostimulatory Properties. Eukaryot Cell. 2015;14:745-54 pubmed publisher
    ..The genes encoding phosphatidylserine synthase (CHO1) and phosphatidylserine decarboxylase (PSD1 and PSD2) are Candida albicans genes involved in phospholipid biosynthesis, and mutations in these genes affect ..
  6. James A, Gowsalya R, Nachiappan V. Dolichyl pyrophosphate phosphatase-mediated N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae. Biochim Biophys Acta. 2016;1861:1705-1718 pubmed publisher
    ..was concomitantly down regulated, which led to the derepression of the phospholipid genes CHO2, OPI3, PSD1, and PSD2 and resulted in increased phospholipid levels...
  7. Di Bartolomeo F, Wagner A, Daum G. Cell biology, physiology and enzymology of phosphatidylserine decarboxylase. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:25-38 pubmed publisher
    ..We also discuss briefly the cellular physiology and the enzymology of Psd2. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
  8. Wu Y, Takar M, Cuentas Condori A, Graham T. Neo1 and phosphatidylethanolamine contribute to vacuole membrane fusion in Saccharomyces cerevisiae. Cell Logist. 2016;6:e1228791 pubmed
    ..Strains deficient in PE synthesis (psd1? psd2?) displayed fragmented vacuoles and the neo1-2 fragmented vacuole phenotype was also suppressed by ..
  9. Miyata N, Miyoshi T, Yamaguchi T, Nakazono T, Tani M, Kuge O. VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae. Biochem J. 2015;472:319-28 pubmed publisher
    ..PSD1 null (psd1Δ) and PSD2 null (psd2Δ) mutants are viable in a synthetic minimal medium, but a psd1Δ psd2Δ double mutant exhibits ..

More Information


  1. Gulshan K, Shahi P, Moye Rowley W. Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance. Mol Biol Cell. 2010;21:443-55 pubmed publisher
    ..Saccharomyces cerevisiae has two different phosphatidylserine decarboxylase enzymes (Psd1 and Psd2) that catalyze formation of phosphatidylethanolamine...
  2. Kawałek A, Jagadeesan C, van der Klei I. Impaired biosynthesis of the non-bilayer lipids phosphatidylethanolamine or cardiolipin does not affect peroxisome biogenesis and proliferation in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2016;480:228-233 pubmed publisher
    ..Analysis of strains deficient in one of the three PE biosynthesis pathways (psd1, psd2 or the triple deletion strain eki1 cki1 dpl1) revealed that in all three strains peroxisome numbers were reduced ..
  3. Kunkle B, Vardarajan B, Naj A, Whitehead P, Rolati S, Slifer S, et al. Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport. JAMA Neurol. 2017;74:1113-1122 pubmed publisher
    ..6) years; and of the 7001 NHW controls, 4215 (60.2%) were women and mean (SD) age was 77.4 (8.6) years. The gene PSD2, for which multiple unrelated NHW cases had rare missense variants, was significantly associated with EOAD (P = ..
  4. Yu L, Dawe R, Boyle P, Gaiteri C, Yang J, Buchman A, et al. Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017;74:1473-1480 pubmed publisher
    ..4 (6.0) years. Four co-expressed genes (PADI2 [Ensembl ENSG00000117115], ZNF385A [Ensembl ENSG00000161642], PSD2 [Ensembl ENSG00000146005], and A2ML1 [Ensembl ENSG00000166535]) were identified, of which higher expressions were ..