PRX

Summary

Gene Symbol: PRX
Description: periaxin
Alias: CMT4F
Species: human

Top Publications

  1. ncbi A comparison of dopamine agonists and catechol-O-methyltransferase inhibitors in Parkinson's disease
    R Inzelberg
    Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel
    Clin Neuropharmacol 23:262-6. 2000
  2. pmc The peroxiredoxin and glutathione peroxidase families in Chlamydomonas reinhardtii
    Régine Dayer
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, CH 8600, Duebendorf, Switzerland
    Genetics 179:41-57. 2008
  3. doi Monitoring of cerebrovascular autoregulation: facts, myths, and missing links
    Marek Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 10:373-86. 2009
  4. pmc Mapping of a new locus for autosomal recessive demyelinating Charcot-Marie-Tooth disease to 19q13.1-13.3 in a large consanguineous Lebanese family: exclusion of MAG as a candidate gene
    V Delague
    Unite de Genetique Medicale, Faculte de Medecine, Université Saint Joseph, Paris, France
    Am J Hum Genet 67:236-43. 2000
  5. ncbi In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 27:168-75. 2007
  6. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:64-71. 2006
  7. ncbi Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxon
    Georg A Petroianu
    Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Arch Toxicol 80:777-84. 2006
  8. ncbi Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in rats
    G A Petroianu
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 25:68-73. 2005
  9. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:262-8. 2006
  10. ncbi Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection
    G Petroianu
    University of Heidelberg at Mannheim, Department of Pharmacology and Toxicology, Maybach Street 14 16, 68169 Mannheim, Germany
    J Appl Toxicol 21:7-13. 2001

Detail Information

Publications147 found, 100 shown here

  1. ncbi A comparison of dopamine agonists and catechol-O-methyltransferase inhibitors in Parkinson's disease
    R Inzelberg
    Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel
    Clin Neuropharmacol 23:262-6. 2000
    To compare the efficacy and tolerability of three dopamine agonists--pergolide (PRG), pramipexole (PRX), and ropinirole (ROP)-and two catechol-O-methyltranferase (COMT) inhibitors-tolcapone (TOL) and entacapone (ENT)-as add-on therapies ..
  2. pmc The peroxiredoxin and glutathione peroxidase families in Chlamydomonas reinhardtii
    Régine Dayer
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, CH 8600, Duebendorf, Switzerland
    Genetics 179:41-57. 2008
    ..PRXs are present in diverse subcellular compartments and divided into four types: 2-cys PRX, 1-cys PRX, PRX-Q, and type II PRX (PRXII)...
  3. doi Monitoring of cerebrovascular autoregulation: facts, myths, and missing links
    Marek Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 10:373-86. 2009
    ..We review a methodology and clinical application of indices useful for monitoring cerebral autoregulation and pressure-reactivity in various scenarios of neuro-critical care...
  4. pmc Mapping of a new locus for autosomal recessive demyelinating Charcot-Marie-Tooth disease to 19q13.1-13.3 in a large consanguineous Lebanese family: exclusion of MAG as a candidate gene
    V Delague
    Unite de Genetique Medicale, Faculte de Medecine, Université Saint Joseph, Paris, France
    Am J Hum Genet 67:236-43. 2000
    ..affecting this family constitutes a previously unknown demyelinating autosomal recessive CMT subtype known as "CMT4F." The myelin-associated glycoprotein (MAG) gene, located on 19q13...
  5. ncbi In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 27:168-75. 2007
    ..Pralidoxime (PRX) is the oxime used in the United States...
  6. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:64-71. 2006
    Oximes are cholinesterase reactivators of use in poisoning with organophosphorus compounds. Pralidoxime (PRX) is used clinically as an adjunct to atropine in such exposure...
  7. ncbi Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxon
    Georg A Petroianu
    Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Arch Toxicol 80:777-84. 2006
    ..POX is a highly toxic non-neuropathic ethyl organophospate. Pralidoxime (PRX) is the enzyme reactivator used by some NATO armies...
  8. ncbi Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in rats
    G A Petroianu
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 25:68-73. 2005
    ..paraoxon, POX) exposure in rats in direct comparison with the therapeutic gold-standard pralidoxime (PRX)...
  9. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:262-8. 2006
    Oximes are cholinesterase reactivators used in organophosphorus poisoning. Clinical experience with pralidoxime (PRX) and other oximes is disappointing and their routine use has been questioned...
  10. ncbi Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection
    G Petroianu
    University of Heidelberg at Mannheim, Department of Pharmacology and Toxicology, Maybach Street 14 16, 68169 Mannheim, Germany
    J Appl Toxicol 21:7-13. 2001
    ..To assess the practical relevance, if any, of these findings, the protective effects of pralidoxime (PRX) and those of lactate had to be compared in the same in vitro model...
  11. ncbi Characterization of a mammalian peroxiredoxin that contains one conserved cysteine
    S W Kang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:6303-11. 1998
    ..TPx homologs, termed peroxiredoxin (Prx), have also been identified and include several proteins, designated 1-Cys Prx, that contain only one conserved ..
  12. pmc Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy
    Ula V Jurkunas
    Schepens Eye Research Institute, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 49:2956-63. 2008
    To compare the relative expression of peroxiredoxin (Prx) proteins in normal human corneal endothelium with endothelium in corneas affected by Fuchs' endothelial dystrophy (FED) and between normal human endothelium and epithelial/stromal ..
  13. ncbi Hyperoxidized peroxiredoxins and glyceraldehyde-3-phosphate dehydrogenase immunoreactivity and protein levels are changed in the gerbil hippocampal CA1 region after transient forebrain ischemia
    In Koo Hwang
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon 200 702, South Korea
    Neurochem Res 32:1530-8. 2007
    ..present study, we investigated transient ischemia-induced chronological changes in hyperoxidized peroxiredoxins (Prx-SO3) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH-SO3) immunoreactivity and protein levels in the gerbil ..
  14. ncbi The thiol-based redox networks of pathogens: unexploited targets in the search for new drugs
    Timo Jaeger
    MOLISA GmbH, Molecular Links Sachsen Anhalt, Universitatsplatz 2, D 39106 Magdeburg, Germany
    Biofactors 27:109-20. 2006
    ..linked via glutaredoxin and plasmoredoxin to terminal thioredoxin peroxidases belonging to both, the peroxiredoxin (Prx) and glutathione peroxidase (GPx) family...
  15. doi Supramolecular control of polyplex dissociation and cell transfection: efficacy of amino groups and threading cyclodextrins in biocleavable polyrotaxanes
    Atsushi Yamashita
    School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1292, Japan
    J Control Release 131:137-44. 2008
    ..onto a poly(ethylene glycol) (PEG) chain capped with benzyloxycarbonyl-L-tyrosine via disulfide linkages (DMAE-SS-PRX), involves the formation of a stable polyion complex (polyplex) against a counter polyanion and the intracellular ..
  16. pmc Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation
    Matty Knight
    Biomedical Research Institute, 12111 Parklawn Drive, Rockville, MD 20852, USA
    Mol Biochem Parasitol 167:20-31. 2009
    ..screened and a partial cDNA encoding an antioxidant enzyme thioredoxin peroxidase (Tpx), or peroxiredoxin (Prx), was identified...
  17. ncbi Characterization of clutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling
    B Vergauwen
    Laboratory of Protein Biochemistry and Protein Engineering, Gent University, 9000 Gent, Belgium
    J Biol Chem 276:20890-7. 2001
    ..We suggest GAR to be the newest member of the class I flavoprotein disulfide reductase family of oxidoreductases...
  18. pmc Divergent light-, ascorbate-, and oxidative stress-dependent regulation of expression of the peroxiredoxin gene family in Arabidopsis
    Frank Horling
    Department of Plant Physiology and Biochemistry W5, University of Bielefeld, 33501 Bielefeld, Germany
    Plant Physiol 131:317-25. 2003
    Peroxiredoxins (prxs) are peroxidases with broad substrate specificity. The seven prx genes expressed in Arabidopsis shoots were analyzed for their expressional response to changing photon fluence rates, oxidative stress, and ascorbate ..
  19. ncbi A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb
    T Nohno
    Department of Pharmacology, Kawasaki Medical School, Kurashiki City, Japan
    Dev Biol 158:254-64. 1993
    We identified a homeobox-containing gene, Prx-1, isolated from the chick limb bud cDNA library. The homeodomain sequence is related to Drosophila paired and goose-berry and mouse Pax-3, Pax-6, and Pax-7...
  20. ncbi Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis
    M F Lu
    Center for Cancer Biology and Nutrition, Texas A and M University, Houston, Texas, 77030 3303, USA
    Dev Biol 205:145-57. 1999
    The closely related homeobox genes prx-1 and prx-2 are expressed in lateral plate and limb bud mesoderm, but targeted inactivation of these genes failed to demonstrate a limb phenotype...
  21. ncbi Synergistic action of piroxicam on the eicosapentaenoic acid-induced apoptosis is associated with enhanced down-regulation of anti-apoptotic Bcl-2 expression but not promoted activation of pro-apoptotic Bid protein
    Lawrence C M Chiu
    Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, P R China
    Oncol Rep 11:225-30. 2004
    ..In this study, effect of piroxicam (PRX), a COX inhibitor, on the EPA-induced apoptosis in HL-60 cells was investigated...
  22. pmc Ol-Prx 3, a member of an additional class of homeobox genes, is unimodally expressed in several domains of the developing and adult central nervous system of the medaka (Oryzias latipes)
    J S Joly
    Laboratoire de Genetique des Poissons, Domaine de Vilvert, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Proc Natl Acad Sci U S A 94:12987-92. 1997
    ..In this context, we report the characterization of Ol-Prx 3 (Oryzias latipes-Prx 3)...
  23. ncbi Cerebrovascular reactivity during hypothermia and rewarming
    A Lavinio
    Department of Clinical Neurosciences, Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Anaesth 99:237-44. 2007
    ..The effects of hypothermia and subsequent rewarming on cerebral vasoreactivity in human TBI are unknown...
  24. doi Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Neurosurg Focus 25:E2. 2008
    ..A cerebrovascular pressure reactivity index (PRx) can be determined as the moving correlation coefficient between mean intracranial pressure (ICP) and mean arterial ..
  25. pmc The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Toxicology 257:95-104. 2009
    ..Trx1) and mitochondrial (Trx2) thioredoxins in the reduced state, and the thioredoxins keep the peroxiredoxins (Prx) reduced, thereby supporting their peroxidase function...
  26. doi PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats
    Stacy L Porvasnik
    Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, Florida 32610 0266, USA
    J Pharmacol Exp Ther 334:364-72. 2010
    ..5-((4-(6-Chlorothieno[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile monofumarate (PRX-08066) is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist that causes selective vasodilation of ..
  27. ncbi Fluorescence quenching of Acridine Orange in microemulsions induced by the non-steroidal anti-inflammatory drug Piroxicam
    Suzana M Andrade
    Centro de Quimica Estrutural, Complexo 1, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
    Photochem Photobiol Sci 2:605-10. 2003
    ..quenching of Acridine Orange (AO) by methyl viologen (MV2+) and the non-steroidal anti-inflammatory drug Piroxicam (Prx), incorporated in sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/isooctane/water and Triton X-100 (Trx-100)/..
  28. pmc Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum
    Derek Parsonage
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 107:6240-5. 2010
    ..Although this Tp peroxiredoxin (Prx) closely resembles AhpC-like Prxs, Tp lacks AhpF, the typical reductant for such enzymes...
  29. doi Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus
    Katia D'Ambrosio
    Istituto di Biostrutture e Bioimmagini CNR, Via Mezzocannone 16, 80134 Naples, Italy
    Proteins 76:995-1006. 2009
    Bcps constitute a group of antioxidant enzymes, belonging to the Prx family, that are widely distributed in bacteria, plants, and fungi. These proteins can contain two conserved cysteines within the CXXXXC motif...
  30. ncbi Crystal structure of an archaeal peroxiredoxin from the aerobic hyperthermophilic crenarchaeon Aeropyrum pernix K1
    Eiichi Mizohata
    RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi, Yokohama 230 0045, Japan
    J Mol Biol 354:317-29. 2005
    ..We present here the X-ray crystal structure of an archaeal Prx from the aerobic hyperthermophilic crenarchaeon, Aeropyrum pernix K1, determined at 2.3 A resolution (Rwork of 17...
  31. ncbi The function of peroxiredoxins in plant organelle redox metabolism
    Karl Josef Dietz
    Biochemistry and Physiology of Plants, W5 134, Bielefeld University, D 33501 Bielefeld, Germany
    J Exp Bot 57:1697-709. 2006
    In 1996, cDNA sequences referred to as plant peroxiredoxins (Prx), i.e. a 1-Cys Prx and a 2-Cys Prx, were reported from barley...
  32. ncbi Association between intracranial, arterial pulse pressure amplitudes and cerebral autoregulation in head injury patients
    P K Eide
    Department of Neurosurgery, The National Hospital Rikshospitalet, Oslo, Norway
    Neurol Res 29:578-82. 2007
    ....
  33. doi Towards clarification of the inhibitory mechanism of wheat bran leachate on Microcystis aeruginosa NIES-843 (Cyanobacteria): physiological responses
    Jihai Shao
    Institute of Hydrobiology, Chinese Academy of Sciences, 430072 Wuhan, People s Republic of China
    Ecotoxicology 19:1634-41. 2010
    ..D1 protein of photosynthetic processes (psbA), synthesis of microcystins (mcyB), antioxidant protein peroxiredoxin (prx), synthesis of fatty acid (fabZ) and the repair of biological macromolecules (recA, grpE) were studied...
  34. ncbi Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120
    Mee Kyung Cha
    Department of Biochemistry, Paichai University, 439 6 Doma 2 Dong Seo Gu, Taejon 302 735, Republic of Korea
    Free Radic Biol Med 42:1736-48. 2007
    ..genome contains seven open reading frames with homology to thiol peroxidase (TPx), also known as peroxiredoxin (Prx)...
  35. ncbi Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans
    Heather Thieringer
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08554, USA
    J Cell Sci 116:1797-804. 2003
    ..green fluorescent protein reporter targeted to the peroxisome, we establish that peroxisomal import is impaired in prx-5(RNAi) nematodes...
  36. ncbi Removal of hydrogen peroxide by a 1-cysteine peroxiredoxin enzyme of the filarial parasite Dirofilaria immitis
    R Chandrashekar
    Heska Corporation, Fort Collins, CO 80525, USA
    Parasitol Res 86:200-6. 2000
    ..of studies carried out on the biochemical activity and on immunolocalization of a recombinant peroxiredoxin (Prx) enzyme from the dog filarial parasite Dirofilaria immitis...
  37. ncbi Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate
    M S Seo
    Laboratory of Cell Signaling and Department of Extramural Affairs, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:20346-54. 2000
    Peroxidases of the peroxiredoxin (Prx) family contain a Cys residue that is preceded by a conserved sequence in the NH(2)-terminal region...
  38. pmc A vacuolar class III peroxidase and the metabolism of anticancer indole alkaloids in Catharanthus roseus: Can peroxidases, secondary metabolites and arabinogalactan proteins be partners in microcompartmentation of cellular reactions?
    Mariana Sottomayor
    IBMC Instituto de Biologia Molecular e Celular Universidade do Porto Porto Portugal
    Plant Signal Behav 3:899-901. 2008
    ..Recently, in a classical function-to-protein-to-gene approach, we have characterized the main class III peroxidase (Prx) expressed in C. roseus leaves, CrPrx1, implicated in a key biosynthetic step of the anticancer alkaloids...
  39. doi Peroxiredoxin IV regulates pro-inflammatory responses in large yellow croaker (Pseudosciaena crocea) and protects against bacterial challenge
    Suhong Yu
    Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, PR China
    J Proteome Res 9:1424-36. 2010
    ..Three Prx family members, namely, Prx I, Prx II, and Prx IV, were upregulated after treatment with the vaccine, indicating ..
  40. doi Evaluation of hepatic changes and local and systemic immune responses in goats immunized with recombinant Peroxiredoxin (Prx) and challenged with Fasciola hepatica
    Ricardo E Mendes
    Department of Anatomy and Comparative Pathology, School of Veterinary Medicine, University of Cordoba, Animal Health Building, Campus Rabanales, Cordoba, Spain
    Vaccine 28:2832-40. 2010
    Protection against Fasciola hepatica in goats immunized with Peroxiredoxin (Prx) was assessed...
  41. doi Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II
    Yuan Li
    Department of Experimental Pathology, Guangxi Cancer Institute, Nanning, China
    Proteomics 8:1490-501. 2008
    ..Peroxiredoxin (Prx) II, one of the candidates with distinct alteration, was further investigated and validated...
  42. pmc Novel protective mechanism against irreversible hyperoxidation of peroxiredoxin: Nalpha-terminal acetylation of human peroxiredoxin II
    Jae Ho Seo
    School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Korea
    J Biol Chem 284:13455-65. 2009
    ..Our comparative study of hyperoxidation and regeneration of Prx I and Prx II in HeLa cells revealed that Prx II is more susceptible than Prx I to hyperoxidation and that the ..
  43. doi PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety
    Susan A Brunelli
    Division of Developmental Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Pharmacol Biochem Behav 94:8-15. 2009
    ..infants (pups: Postnatal Day 11+/-1) were compared to those of randomly-bred controls in response to EPIX compound PRX-00023, a unique serotonin (5-HT) agonist, acting exclusively at the 5-HT1A receptor, or buspirone, a nonspecific ..
  44. pmc Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
    Tsutomu Nakamura
    National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Proc Natl Acad Sci U S A 105:6238-42. 2008
    ..through a hypervalent sulfur intermediate by presenting crystallographic evidence from an archaeal peroxiredoxin (Prx), the thioredoxin peroxidase from Aeropyrum pernix K1 (ApTPx)...
  45. ncbi Dual role of peroxiredoxin I in macrophage-derived foam cells
    James P Conway
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 281:27991-8001. 2006
    ..Specifically, our experiments have identified peroxiredoxin I (Prx I) as one of these up-regulated proteins...
  46. ncbi Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates
    K C Das
    Department of Molecular Biology, University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Respir Cell Mol Biol 25:226-32. 2001
    Peroxiredoxin (Prx) is an important antioxidant defense enzyme that reduces hydrogen peroxide to molecular oxygen by using reducing equivalents from thioredoxin...
  47. ncbi Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines
    Amit Chaudhary
    Department of Pharmacology and Environmental Toxicology Research Program, School of Pharmacy, The University of Mississippi, 315 Faser Hall, Box 1848, University, MS 38677, USA
    Toxicol Appl Pharmacol 220:197-210. 2007
    ..Western blots confirmed that BaP increased peroxiredoxin (Prx) Prx I and decreased Prx II in 22Rv1 cells. Similar results were found in PrEC normal prostate epithelial cells...
  48. ncbi Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe
    Ga Young Kang
    Division of Life Sciences, College of Natural Sciences, Kangwon National University, 192 1 Hyoja 2 Dong, Chuncheon, Korea
    Mol Biol Rep 35:387-95. 2008
    A gene encoding a putative peroxiredoxin (Prx) of the fission yeast Schizosaccharomyces pombe was characterized and its regulation was studied...
  49. pmc COMe: the ontology of bioinorganic proteins
    Kirill Degtyarenko
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, United Kingdom
    BMC Struct Biol 4:3. 2004
    ....
  50. doi Cloning and functional characterization of a typical 2-Cys peroxiredoxin from southern bluefin tuna (Thunnus maccoyii)
    Drew L Sutton
    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide SA5001, Australia
    Comp Biochem Physiol B Biochem Mol Biol 156:97-106. 2010
    ..Here we describe the cloning and functional characterization of a Prx 2 cDNA from southern bluefin tuna (SBT, Thunnus maccoyii), an important aquaculture species in South Australia...
  51. ncbi Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes
    Luis A Ralat
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    Biochemistry 45:360-72. 2006
    Glutathione S-transferase pi (GST pi) has been shown to reactivate oxidized 1-cysteine peroxiredoxin (1-Cys Prx, Prx VI, Prdx6, and AOP2)...
  52. doi Peroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but not nitric oxide
    Takashi Kumagai
    Section of Environmental Parasitology, Department of International Health Development, Division of Public Health, Tokyo Medical and Dental University Graduate School, Japan
    Mol Biochem Parasitol 164:26-31. 2009
    Three peroxiredoxins (Prxs) are expressed during most of the developmental stages in the schistosome. Prx-1 is localized on the surface of the schistosomula and adults of Schistosoma japonicum, while Prx-2 is localized in the sub-..
  53. pmc The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 47:1477-85. 2009
    ..The Trx's keep many intracellular proteins reduced, including the peroxiredoxins (Prx's)...
  54. ncbi Distribution of Prx-linked hydroperoxide reductase activity among microorganisms
    Kouji Takeda
    Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan
    Biosci Biotechnol Biochem 68:20-7. 2004
    Peroxiredoxin (Prx) constitutes a large family of enzymes found in microorganisms, animals, and plants, but the detection of the activities of Prx-linked hydroperoxide reductases (peroxiredoxin reductases) in cell extracts, and the ..
  55. ncbi Proteomics viewed on stress response of thermophilic bacterium Bacillus stearothermophilus TLS33
    Supachai Topanurak
    Institute of Biological Chemistry and Genomics, Academia Sinica, Taipei, Taiwan
    Proteomics 5:3722-30. 2005
    ..There are four isoforms of peroxiredoxin, denoted as Prx I, Prx II, Prx III and Prx IV, which are observed at the same molecular weight of 27 kDa but differ in pI values of ..
  56. pmc Effects of xenon and hypothermia on cerebrovascular pressure reactivity in newborn global hypoxic-ischemic pig model
    Elavazhagan Chakkarapani
    Neonatal Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK
    J Cereb Blood Flow Metab 33:1752-60. 2013
    ..We investigated whether cerebrovascular pressure reactivity (PRx), an element of cerebral autoregulation that is calculated as a moving correlation coefficient between averages of ..
  57. ncbi Vesicular transport route of horseradish C1a peroxidase is regulated by N- and C-terminal propeptides in tobacco cells
    T Matsui
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama cho, Ikoma shi, 630 0101 Nara, Japan
    Appl Microbiol Biotechnol 62:517-22. 2003
    Peroxidases (PRX, EC 1.11.1.7) are widely distributed across microorganisms, plants, and animals; and, in plants, they have been implicated in a variety of secondary metabolic reactions...
  58. ncbi Variable overoxidation of peroxiredoxins in human lung cells in severe oxidative stress
    Siri T Lehtonen
    Department of Internal Medicine, University of Oulu, Oulu University Hospital, Finland
    Am J Physiol Lung Cell Mol Physiol 288:L997-1001. 2005
    ..Prxs I-IV form dimers held together by disulfide bonds, Prx V forms intramolecular bond, but the mechanism of Prx VI, so-called 1-Cys Prx, is still unclear...
  59. ncbi Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism
    Aude Echalier
    LCM3B, Groupe Biocristallographie, Université Henri Poincaré Nancy1, UMR CNRS 7036, 54506 Vandoeuvre, France
    Biochemistry 44:1755-67. 2005
    ..We present here a combined X-ray and nuclear magnetic resonance (NMR) study of a plant Prx that belongs to the D-Prx (type II) subfamily...
  60. ncbi Characterization of cerebrovascular reactivity after craniectomy for acute brain injury
    E C Wang
    Department of Neurosurgery, National Neuroscience Institute, Singapore
    Br J Neurosurg 20:24-30. 2006
    ..It has been previously demonstrated that the pressure-reactivity index (PRx) can be used to reflect global cerebrovascular reactivity with changes in ABP...
  61. ncbi Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death
    Young Do Yo
    Korea University Cancer Institute, Korea University College of Medicine, Seoul 136 705, Korea
    Exp Mol Med 34:273-7. 2002
    Peroxiredoxin II (Prx II) is known not only to protect cells from oxidative damage caused by hydrogen peroxide (H202), but also to endow cancer cells with resistance to both H202 and cisplatin and to grant them radioresistance...
  62. pmc Expression of cytosolic peroxiredoxins in Plasmodium berghei ookinetes is regulated by environmental factors in the mosquito bloodmeal
    Benjamin A Turturice
    Department of Biology, Loyola University Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 9:e1003136. 2013
    ..cytosolic antioxidant proteins, thioredoxin-1 (Trx-1), peroxiredoxin-1 (TPx-1), and 1-Cys peroxiredoxin (1-Cys Prx), in developing ookinetes of the rodent parasite Plasmodium berghei under various growth conditions...
  63. pmc Impaired cerebrovascular reactivity after acute traumatic brain injury can be detected by wavelet phase coherence analysis of the intracranial and arterial blood pressure signals
    Per Kvandal
    Intensive Care Unit, Oslo University Hospital, 0407, Ulleval, Oslo, Norway
    J Clin Monit Comput 27:375-83. 2013
    ..Patients were separated into normal or impaired cerebrovascular reactivity, based on the pressure reactivity index (PRx)...
  64. doi Secretory expression and characterization of a novel peroxiredoxin for zearalenone detoxification in Saccharomyces cerevisiae
    Yuqian Tang
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China
    Microbiol Res 168:6-11. 2013
    ..ZEN is oxidized into smaller estrogenic metabolites by a novel peroxiredoxin (Prx) isolated from Acinetobacter sp. SM04...
  65. doi Self-construction of supramolecular polyrotaxane films by an electrotriggered morphogen-driven process
    Gaulthier Rydzek
    INSERM, UMR S 1121, Biomatériaux et Bioingénierie, 11 rue Humann, F 67085 Strasbourg Cedex, France
    Langmuir 29:10776-84. 2013
    ..Herein we describe the preparation of one-pot supramolecular polyrotaxane (PRX) films using the morphogen-driven self-construction process...
  66. pmc Chloroplast NADPH-dependent thioredoxin reductase from Chlorella vulgaris alleviates environmental stresses in yeast together with 2-Cys peroxiredoxin
    Takeshi Machida
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e45988. 2012
    Chloroplast NADPH-dependent thioredoxin reductase (NTRC) catalyzes the reduction of 2-Cys peroxiredoxin (2-Cys Prx) and, thus, probably functions as an antioxidant system...
  67. doi Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability
    Ying Hao Han
    KRIBB, Daejeon, Republic of Korea
    Biochem Biophys Res Commun 426:427-32. 2012
    ..Here, we investigated the potential role of peroxiredoxin II (Prx II) in preventing Hb aggregation induced by reactive oxygen species (ROS) using Prx II knockout mice and RBCs of ..
  68. pmc Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells
    Pamela Lopert
    Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 7:e50683. 2012
    ..H₂O₂) in a substrate- and respiration-dependent manner predominantly via the thioredoxin/peroxiredoxin (Trx/Prx) system. The goal of this study was to determine the role of Trx/Prx system in dopaminergic cell death...
  69. doi Late-onset Charcot-Marie-Tooth disease 4F caused by periaxin gene mutation
    Shoko Tokunaga
    Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima City, Kagoshima, Japan
    Neurogenetics 13:359-65. 2012
    ..PRX mutations usually lead to early-onset, autosomal-recessive demyelinating CMT neuropathy 4F (CMT4F) or Dejerine-Sottas disease; their clinical phenotypes are severe...
  70. doi NTRC and chloroplast-generated reactive oxygen species regulate Pseudomonas syringae pv. tomato disease development in tomato and arabidopsis
    Yasuhiro Ishiga
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, OK 73401, USA
    Mol Plant Microbe Interact 25:294-306. 2012
    ..Loss-of-function analysis of Prx and NADPH-dependent thioredoxin reductase C (NTRC), the central players of a chloroplast redox detoxification ..
  71. pmc Protein glutathionylation in the regulation of peroxiredoxins: a family of thiol-specific peroxidases that function as antioxidants, molecular chaperones, and signal modulators
    Ho Zoon Chae
    School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea
    Antioxid Redox Signal 16:506-23. 2012
    ..Typical 2-Cys Prx also functions as a molecular chaperone when it exists as a decamer and/or higher molecular weight complexes...
  72. doi Molecular and functional properties of three different peroxiredoxin isotypes in Chinese cabbage
    Sun Young Kim
    Division of Applied Life Sciences Brain Korea 21 Program, Gyeongsang National University, Jinju 660 701, Korea
    Mol Cells 33:27-33. 2012
    ..The three Prx isotypes of Chinese cabbage, namely C1C-Prx, C2C-Prx, and C-PrxII, have recently been identified and characterized...
  73. doi Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes
    Yuma Yamada
    Laboratory for Molecular Design of Pharmaceutics, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Biomaterials 33:3952-8. 2012
    ..exists between the efficiency of DNA release and transfection activity, when biocleavable polyrotaxanes (DMAE-SS-PRX), in which the cationic density can be easily controlled...
  74. doi Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Int Immunopharmacol 9:1281-8. 2009
    Peroxiredoxin (Prx) I, a ubiquitous antioxidant enzyme, is known to protect against inflammation; however, its role in the allergic inflammation remains unidentified...
  75. doi A colorimetric assay for sulfiredoxin activity using inorganic phosphate measurement
    Hojin Kim
    Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu Seoul 120 750, South Korea
    Anal Biochem 393:36-40. 2009
    2-Cys peroxiredoxin (Prx) is the major subgroup of a family of Prx enzymes that reduce peroxide molecules such as hydrogen peroxide (H(2)O(2))...
  76. doi Continuous monitoring of cerebrovascular pressure reactivity after traumatic brain injury in children
    Ken M Brady
    Division of Pediatric Anesthesiology and Critical Care Medicine, Johns Department of aAnesthesiology and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Pediatrics 124:e1205-12. 2009
    We hypothesized that pressure reactivity index (PRx) values indicating preserved cerebrovascular pressure autoregulation would be associated with survival in children with traumatic brain injury (TBI)...
  77. ncbi Isoform-specific downregulation of peroxiredoxin in human failing myocardium
    Klara Brixius
    Department of Molecular and Cellular Sport Medicine, Institute of Cardiology and Sport Medicine, German Sport University, Germany
    Life Sci 81:823-31. 2007
    Peroxiredoxins (Prx) are a family of antioxidant thioredoxin or glutathione dependent peroxidases...
  78. ncbi Characterization of the murine gene encoding 1-Cys peroxiredoxin and identification of highly homologous genes
    T H Lee
    Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Taejon 305 600, South Korea
    Gene 234:337-44. 1999
    A new type of peroxiredoxin, named 1-Cys peroxiredoxin (1-Cys Prx), reduces hydrogen peroxide with the use of electrons from unidentified electron donor(s)...
  79. doi A theoretical and spectroscopic study of conformational structures of piroxicam
    Kely Ferreira de Souza
    Instituto de Quimica, Universidade Estadual de Campinas, PO Box 6154, 13083 970 Campinas, Sao Paulo, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 75:901-7. 2010
    Piroxicam (PRX) has been widely studied in an attempt to elucidate the causes and mechanisms of its side effects, mainly the photo-toxicity...
  80. doi Molecular cloning and characterization of two genes encoding 2-Cys peroxiredoxins from Fasciola gigantica
    Kulathida Chaithirayanon
    Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Rd, Bangkok 10400, Thailand
    Exp Parasitol 125:106-13. 2010
    In Fasciola species, peroxiredoxin (Prx) serves as the major antioxidant enzyme to remove hydrogen peroxide that is generated from various metabolic reactions, because the parasites lack catalase, and only express glutathione peroxidases ..
  81. pmc Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin
    Ji Won Park
    Laboratory of Biochemistry, Biochemistry and Biophysics Center, Division of Intramural Research, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    J Biol Chem 284:23364-74. 2009
    ..We show that deglutathionylation of 2-Cys Prx, a family of peroxidases, is specifically catalyzed by Srx...
  82. pmc Protein engineering of the quaternary sulfiredoxin.peroxiredoxin enzyme.substrate complex reveals the molecular basis for cysteine sulfinic acid phosphorylation
    Thomas J Jönsson
    Center for Structural Biology and Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 284:33305-10. 2009
    Oxidative stress can damage the active site cysteine of the antioxidant enzyme peroxiredoxin (Prx) to the sulfinic acid form, Prx-SO(2)(-). This modification leads to inactivation...
  83. pmc Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy
    Ana P D Demasi
    Department of Oral Pathology, São Leopoldo Mandic Research Center, Campinas, Brazil
    Int J Exp Pathol 91:107-13. 2010
    ..immunohistochemistry the expression of glucose transporter 1 (Glut-1), mitochondrial antigen and peroxiredoxin I (Prx I) in samples of MEC from different histological grades...
  84. pmc Peroxiredoxin I regulates the component expression of γ-secretase complex causing the Alzheimer's disease
    Young Ju Lee
    Department of Biomaterials Science, College of Natural Resources and Life Science, Pusan National University, Miryang, Korea
    Lab Anim Res 27:293-9. 2011
    Peroxiredoxin I (Prx I) is a member of the peroxiredoxins (Prxs) family, which are antioxidant enzymes that regulate various cellular process via intracellular oxidative signal pathways...
  85. doi Peroxiredoxin-2 upregulated by NF-κB attenuates oxidative stress during the differentiation of muscle-derived C2C12 cells
    Hyeran Won
    Department of Biochemistry and Molecular Biology BK21 project, Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
    Antioxid Redox Signal 16:245-61. 2012
    ..Peroxiredoxin-2 (Prx-2) is an abundant mammalian enzyme that protects against oxidative stress...
  86. pmc Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis
    Sun Hee Yim
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 286:39002-12. 2011
    ..In the case of Prx I-III, the disulfide is reduced by thioredoxin, thus enabling these proteins to function as peroxidases...
  87. doi Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis
    A Morinaka
    Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, Osaka, Japan
    Oncogene 30:4208-18. 2011
    ..However, the mechanism underlying MST1 activation by H₂O₂ remains unknown. Here we show that peroxiredoxin-I (PRX-I) is an essential intermediate in H₂O₂-induced MST1 activation and cisplatin-induced cell death through p53...
  88. doi 5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment
    Fei Shen
    Department of Pharmacology, Theravance Inc, 901 Gateway Boulevard, South San Francisco, CA 94080, USA
    Neuropharmacology 61:69-79. 2011
    ..In this study, the preclinical properties of three structurally-distinct 5-HT(4) receptor selective agonists, PRX-03140, velusetrag and TD-8954, were studied to assess their potential for symptomatic and disease-modifying benefit ..
  89. doi Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver
    Soo Han Bae
    Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Hepatology 53:945-53. 2011
    ..The active site cysteine residue of members of the 2-Cys Prx subgroup (Prx I to IV) of Prxs is hyperoxidized to cysteine sulfinic acid (Cys-SO(2) ) during catalysis with ..
  90. pmc The intracellular redox stress caused by hexavalent chromium is selective for proteins that have key roles in cell survival and thiol redox control
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Toxicology 281:37-47. 2011
    ..irreversible inhibition of thioredoxin reductase (TrxR) and the oxidation of thioredoxins (Trx) and peroxiredoxins (Prx)...
  91. pmc The dual-targeted plant sulfiredoxin retroreduces the sulfinic form of atypical mitochondrial peroxiredoxin
    Iván Iglesias-Baena
    Department of Biochemistry and Cellular and Molecular Biology of Plants, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, E 18008, Granada, Spain
    Plant Physiol 155:944-55. 2011
    ..In plants, Srx as well as typical 2-cysteine Prx have been considered as enzymes with exclusive chloroplast localization...
  92. doi Peroxiredoxin III protects pancreatic ß cells from apoptosis
    Gabriele Wolf
    Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Klinikum, Sauerbruchstrasse, D 17487 Greifswald, Germany
    J Endocrinol 207:163-75. 2010
    ..For this reason, there is a considerable interest in the mitochondrial peroxiredoxin III (PRX III), a thioredoxin-dependent peroxide reductase, which was shown to be able to protect against both oxidative and ..
  93. doi Evaluation of the cerebrovascular pressure reactivity index using non-invasive finapres arterial blood pressure
    M Kasprowicz
    Addenbrooke s Hospital, Cambridge, UK
    Physiol Meas 31:1217-28. 2010
    A pressure reactivity index (PRx) can be assessed in patients with continuous monitoring of arterial blood pressure (ABP) and intracranial pressure (ICP) as a moving correlation coefficient between slow fluctuations of these two signals ..
  94. ncbi Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds
    E J Stelnicki
    Department of Surgery, University of California, San Francisco, USA
    J Invest Dermatol 111:57-63. 1998
    ..Two novel human homeobox genes, PRX-2 and HOXB13, were identified that were differentially expressed during fetal versus adult wound healing...
  95. doi Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades
    Hu Nan Sun
    Aging Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon 305 806, Republic of Korea
    J Neurochem 114:39-50. 2010
    ..We demonstrate that microglial peroxiredoxin (Prx) 5 expression is up-regulated by lipopolysaccharide (LPS) through activation of the ROS-sensitive signaling pathway ..
  96. ncbi Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member
    A Matsumoto
    Department of Biochemistry, Osaka University Medical School, Suita, Japan
    FEBS Lett 443:246-50. 1999
    Peroxiredoxin (PRx) exhibits thioredoxin-dependent peroxidase activity and constitutes a family of proteins...
  97. pmc The influence of a pre-exercise sports drink (PRX) on factors related to maximal aerobic performance
    Allyn Byars
    Department of Kinesiology, Angelo State University, San Angelo, TX 76909, USA
    J Int Soc Sports Nutr 7:12. 2010
    Pre-exercise sports drinks (PRX) are commonly used as ergogenic aids in athletic competitions requiring aerobic power. However, in most cases, claims regarding their effectiveness have not been substantiated...
  98. doi Upregulation of peroxiredeoxin III in the hippocampus of acute immobilization stress model rats and the Foxo3a-dependent expression in PC12 cells
    Hee Jeong Jeong
    Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, South Korea
    Cell Mol Neurobiol 31:1041-6. 2011
    ..This study investigated whether acute stress altered the expression pattern of peroxiredoxin (Prx) III, which is an antioxidant enzyme that controls cytokine-induced peroxide levels...
  99. pmc Characterization of plant sulfiredoxin and role of sulphinic form of 2-Cys peroxiredoxin
    Iván Iglesias-Baena
    Department of Biochemistry and Cellular and Molecular Biology of Plants, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, C Profesor Albareda 1, E 18008 Granada, Spain
    J Exp Bot 61:1509-21. 2010
    The antioxidant function of 2-Cys peroxiredoxin (Prx) involves the oxidation of its conserved peroxidatic cysteine to sulphenic acid that is recycled by a reductor agent...
  100. ncbi Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer
    Pei Jou Chua
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, and Department of Pathology, Singapore General Hospital, MD10, S 117 597, Singapore
    Int J Oncol 36:359-64. 2010
    Peroxiredoxin III (Prx III), an antioxidant protein found in mitochondria, plays an essential role in mitochondrial homeostasis. Aberrant expression of Prx III has been implicated in the tumorigenesis of various cancers...
  101. ncbi ICM+, a flexible platform for investigations of cerebrospinal dynamics in clinical practice
    P Smielewski
    Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrookes Hospital, Level 4, A Block, Cambridge CB0 2QQ, UK
    Acta Neurochir Suppl 102:145-51. 2008
    ..For technically minded researchers there is a plug-in mechanism facilitating registration of third party libraries of functions and analysis tools...

Research Grants64

  1. Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Systems
    Leslie Poole; Fiscal Year: 2009
    ..We have developed expertise in Prx enzymology over more than a decade of characterizing of Prxs from pathogenic bacteria (e.g...
  2. Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Systems
    Leslie Poole; Fiscal Year: 2007
    ..We have developed expertise in Prx enzymology over more than a decade of characterizing of Prxs from pathogenic bacteria (e.g...
  3. Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
    Leslie B Poole; Fiscal Year: 2010
    ..We have developed expertise in Prx enzymology over more than 15 years of characterizing of Prxs from pathogenic bacteria (e.g...
  4. MECHANISTIC STUDIES OF ALKYL HYDROPEROXIDE REDUCTASE
    Leslie Poole; Fiscal Year: 2005
    ..AhpC, the cysteine-based peroxidase component, is a member of the ubiquitous "peroxiredoxin" (Prx) family and reduces H2O2 and organic hydroperoxides through transient generation of a cysteine sulfenic acid on the ..
  5. NEW HOMEBOX GENES IN SCARLESS FETAL WOUND HEALING
    Corey Largman; Fiscal Year: 2001
    ..They have cloned two new homeobox genes (PRX-2 and HOXB13) from regenerating wounded human fetal skin which met criteria for influencing fetal skin regeneration...
  6. Peroxiredoxin 6 as an Anti-oxidant Enzyme
    Aron B Fisher; Fiscal Year: 2010
    ..factor Nrf2, and have developed a model based on lipid binding studies for the coordination of the peroxidase (Prx) and phospholipase (PLA2) activities of the protein. We are now seeking 5 years of support to extend these studies...
  7. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005
    ..Schistosoma mansoni peroxiredoxins (Prx) are important parasite antioxidant proteins that play a crucial role in redox balance mechanisms...
  8. Laminin receptors and signals in Schwann cells
    MARIA FELTRI; Fiscal Year: 2007
    ..A laminin receptor, dystroglycan, also interacts with periaxin, mutated in Charcot-Marie-Tooth 4F (CMT4F)...
  9. Laminin receptors and signals in Schwann cells
    MARIA L FELTRI; Fiscal Year: 2010
    ..A laminin receptor, dystroglycan, also interacts with periaxin, mutated in Charcot-Marie-Tooth 4F (CMT4F)...
  10. Prx homebox genes in pulmonary vascular homeostasis
    Peter Jones; Fiscal Year: 2006
    ..These findings support the general hypotheses that Prx genes are regulated by changes in cell adhesion to the ECM, and that Prx proteins play key roles in remodeling PM ..
  11. Glutathione S-Transferases: Novel Regulators of Cellular Stress and Apoptosis
    ROBERTA COLMAN; Fiscal Year: 2009
    ..the cellular response to oxidative stress, since GSTpi activates the anti-oxidant enzyme 1-Cys peroxiredoxin (1-Cys Prx); and GSTs influence cell signaling through interactions with Jun N-terminal Kinase (JNK) and Apoptosis Signal-..
  12. Glutathione S-Transferases: Novel Regulators of Cellular Stress and Apoptosis
    ROBERTA COLMAN; Fiscal Year: 2007
    ..the cellular response to oxidative stress, since GSTpi activates the anti-oxidant enzyme 1-Cys peroxiredoxin (1-Cys Prx); and GSTs influence cell signaling through interactions with Jun N-terminal Kinase (JNK) and Apoptosis Signal-..
  13. Cyclooxygenases in Skeletal Repair
    Xinping Zhang; Fiscal Year: 2010
    ..In Aim1, we will characterizes fracture healing in COX-2f/f;Prx-1Cre and EP4f/-;Prx1Cre mice, in which COX-2 or EP4 receptor are deleted in mesenchymal cells or chondrocytes ..
  14. Cyclooxygenases in Skeletal Repair
    REGIS O KEEFE; Fiscal Year: 2009
    ..In Aim1, we will characterizes fracture healing in COX-2f/f; Prx-1Cre and EP4f/-;Prx1Cre mice, in which COX-2 or EP4 receptor are deleted in mesenchymal cells or chondrocytes ..
  15. Phthalate-induced testicular mitochondrial dysfunction
    THOMAS ONORATO; Fiscal Year: 2005
    ..objective are to: (1) test the postulate that MEHP affects testicular expression of the antioxidant peroxiredoxins (Prx), (2) determine whether MEHP exposure leads to Prx3 inactivation in GC, but not in SC, (3) establish whether Prx3 ..
  16. Prx1 in malignant progression of prostate cancer
    Candace S Johnson; Fiscal Year: 2010
    ..However, the effects of Prx expression in human cancers, their influence on cancer therapy, and the regulatory basis of their expression in ..
  17. Peroxiredoxin 1 in radiotherapy of lung cancer
    Young Mee Park; Fiscal Year: 2007
    ..However, the effects of Prx expression in human cancers, their influence on cancer therapy, and the regulatory basis for their expression in ..
  18. Prx1 in malignant progression of prostate cancer
    Young Mee Park; Fiscal Year: 2007
    ..However, the effects of Prx expression in human cancers, their influence on cancer therapy, and the regulatory basis of their expression in ..
  19. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2007
    ..We plan to accomplish our goal by addressing five Specific Aims: i) to study if peroxiredoxin (Prx), the intracellular antioxidant protein with thioredoxin peroxidase activity, is responsible for the ..
  20. Structures & Redox Chemistry in Sulfinic Acid Reduction
    W Lowther; Fiscal Year: 2009
    ..This discovery shattered the dogma of the irreversibility of overoxidation for the Prx enzyme family...
  21. Redox control of CD8 T cell proliferation, differentiation and death
    JASON MITCHELL GRAYSON; Fiscal Year: 2010
    ..TCR transgenic mice that overexpress both catalase and Cu superoxide dismutase (CAT/SOD) or lack peroxiredoxin II (Prx II -/-) will be used...
  22. PROTON MRS STUDIES IN GENERALIZED ANXIETY DISORDER
    Sanjay Mathew; Fiscal Year: 2007
    ..A specific long-term goal is for the candidate to develop sufficient expertise in MRS to sustain valid and creative application to problems of GAD and related conditions. ..
  23. Targets in Mycobacterium Tuberculosis: Stress Resistance & Repair
    Carl Nathan; Fiscal Year: 2007
    ..The fundamental novelty of this work is to broaden the range of targets to include enzymes of intermediary metabolism and DNA repair. ..
  24. TGF-BETA AND IGF IN MESENCHYMAL STEM CELL CHONDROGENESIS
    Anna Spagnoli; Fiscal Year: 2007
    ..Understanding the role of TGF-beta and IGF-I in the chondrogenic potential of MSC will provide critical information for the development of an ex-vivo MSC-based TGF-beta and IGF-I delivery system capable of potentiating fracture healing. ..
  25. MACROPHAGES, DENDRITIC CELLS AND PATHOGENS
    Carl Nathan; Fiscal Year: 2007
    ..Cores provide for BSL3 wet lab and mouse work; microarray analysis of gene expression; computation and comparison of gene expression results; and high throughput screening of chemical libraries. ..
  26. Biology of lipoamide dehydrogenase and 2-hydroxy-3-oxoadipate synthase in Mtb
    Carl F Nathan; Fiscal Year: 2011
    ..Compounds developed here will inhibit two enzymes that are required by non-replicating Mtb (Lpd) or seem likely to be so (HOAS) and along with metabolomic studies will shed fundamental new light on Mtb's intermediary metabolism. ..