PRTN3

Summary

Gene Symbol: PRTN3
Description: proteinase 3
Alias: ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, myeloblastin, C-ANCA antigen, Wegener granulomatosis autoantigen, azurophil granule protein 7, leukocyte proteinase 3, neutrophil proteinase 4, serine proteinase, neutrophil, wegener autoantigen
Species: human
Products:     PRTN3

Top Publications

  1. Bories D, Raynal M, Solomon D, Darzynkiewicz Z, Cayre Y. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. Cell. 1989;59:959-68 pubmed
    ..We have named this protease myeloblastin. Down-regulation of myeloblastin mRNA occurs with both monocytic and granulocytic inducers...
  2. Coeshott C, Ohnemus C, Pilyavskaya A, Ross S, Wieczorek M, Kroona H, et al. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc Natl Acad Sci U S A. 1999;96:6261-6 pubmed
    ..procytokines to the proteolytic enzymes produced by activated neutrophils, neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (Cat G)...
  3. Loew D, Perrault C, Morales M, Moog S, Ravanat C, Schuhler S, et al. Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry. Biochemistry. 2000;39:10812-22 pubmed
    ..This strategy provides results which can be extended to the native receptor to predict its activation or inactivation, and it could likewise be used to study other PARs or protease-dependent processes. ..
  4. Sørensen O, Follin P, Johnsen A, Calafat J, Tjabringa G, Hiemstra P, et al. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood. 2001;97:3951-9 pubmed
    ..Blood. 2001;97:3951-3959) ..
  5. Preston G, Zarella C, Pendergraft W, Rudolph E, Yang J, Sekura S, et al. Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. J Am Soc Nephrol. 2002;13:2840-9 pubmed
    ..This study reports that the release of neutrophilic and monocytic proteases, such as proteinase 3 (PR3) and human neutrophil elastase (HNE), can result in their entry into endothelial cells coincident with the ..
  6. Cheadle C, Berger A, Andrade F, James R, Johnson K, Watkins T, et al. Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis. Arthritis Rheum. 2010;62:1744-54 pubmed publisher
    ..Longitudinal changes in proteinase 3 (PR3) gene expression were evaluated using reverse transcription-polymerase chain reaction, and clinical outcomes, ..
  7. Abdgawad M, Gunnarsson L, Bengtsson A, Geborek P, Nilsson L, Segelmark M, et al. Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression. Clin Exp Immunol. 2010;161:89-97 pubmed publisher
    Proteinase 3 (PR3) is a major autoantigen in anti-neutrophil cytoplasmic antibodies (ANCA)-associated systemic vasculitis (AASV), and the proportion of neutrophils expressing PR3 on their membrane (mPR3+) is increased in AASV...
  8. Sturrock A, Franklin K, Rao G, Marshall B, Rebentisch M, Lemons R, et al. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. J Biol Chem. 1992;267:21193-9 pubmed
    ..It is identical to the target autoantigen (c-ANCA) associated with Wegener's granulomatosis and to myeloblastin, a serine proteinase first identified in HL-60 leukemia cells...
  9. Rao N, Wehner N, Marshall B, Gray W, Gray B, Hoidal J. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. J Biol Chem. 1991;266:9540-8 pubmed
    ..In contrast to elastase and cathepsin G, PR-3 is not inhibited by secretory leukoprotease inhibitor and is weakly inhibited by eglin c. Thus, PR-3 is distinct from the other PMNL proteinases. ..

More Information

Publications129 found, 100 shown here

  1. Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, et al. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. J Exp Med. 1990;172:1709-15 pubmed
    ..Thus, proteinase 3 may share the role previously attributed to neutrophil elastase in tissue damage, and has the potential to function as an antimicrobial agent. ..
  2. Gabay J, Scott R, Campanelli D, Griffith J, Wilde C, Marra M, et al. Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1989;86:5610-4 pubmed
    ..The other, named azurocidin, was abundant and comparable to bactericidal permeability-increasing factor in its contribution to the killing of Escherichia coli. ..
  3. Jiang B, Grage Griebenow E, Csernok E, Butherus K, Ehlers S, Gross W, et al. The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DC. Clin Exp Rheumatol. 2010;28:56-61 pubmed
    ..cells of Wegener's granulomatosis (WG) patients and healthy controls (HC) and to investigate whether Proteinase 3 (PR3, a serine protease which can activate PAR2) induces maturation of human DC-like monocytes and murine Flt-3 ligand- ..
  4. Cui Z, Zhao M, Segelmark M, Hellmark T. Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are present in normal individuals. Kidney Int. 2010;78:590-7 pubmed publisher
    ..In this study, we determined whether natural autoantibodies against myeloperoxidase (MPO), proteinase 3 (PR3), and GBM were present in each of 10 healthy Chinese and Swedish individuals, negative for all three antigens by ..
  5. van Weelden M, Viola G, Kozu K, Aikawa N, Ivo C, Silva C. [Disseminated histoplamosis in adolescent mimicking granulomatosis with polyangiitis]. Rev Bras Reumatol. 2015;: pubmed publisher
    ..We reported a progressive disseminated histoplasmosis case mimicking GPA. Histoplasmosis infection should be considered in immunocompetent subjects with uncommon clinical manifestations, such as arthritis, nephritis and epididymitis. ..
  6. Filho J, Ogawa M, de Souza Andrade T, de Andrade Cordeiro Gadelha S, Fernandes P, Queiroz A, et al. Spectrum of acute kidney injury associated with cocaine use: report of three cases. BMC Nephrol. 2019;20:99 pubmed publisher
    ..Emphasis should be given to rhabdomyolysis due to its higher prevalence. Considering the increasing rates of cocaine use, especially with the use of adulterating substances, these pathologies will likely be increasingly prevalent. ..
  7. Snipaitiene A, Sileikiene R, Klimaite J, Jasinskiene E, Uktveris R, Jankauskaite L. Unusual case of chronic recurrent multifocal osteomyelitis. Pediatr Rheumatol Online J. 2018;16:49 pubmed publisher
    ..Furthermore, there is a lack of specific biomarkers for CRMO and more studies are necessary to identify CRMO's characteristic patterns and how to best monitor disease progression. ..
  8. Skopelja Gardner S, Jones J, Rigby W. "NETtling" the host: Breaking of tolerance in chronic inflammation and chronic infection. J Autoimmun. 2018;88:1-10 pubmed publisher
    ..e. citrullinated and carbamylated proteins targeted by anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein antibodies (ACarPA), respectively, localize to the NETs...
  9. Blachère N, Parveen S, Fak J, Frank M, Orange D. Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen. Arthritis Res Ther. 2015;17:369 pubmed publisher
    Neutrophil activation induces citrullination of intracellular targets of anticitrullinated peptide antibodies (ACPA), which are specific for rheumatoid arthritis (RA)...
  10. Astorri E, Nerviani A, Bombardieri M, Pitzalis C. Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: role of synovial pathobiology. Curr Pharm Des. 2015;21:2216-24 pubmed
    ..have been associated with RA such as rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA)...
  11. Frombach J, Sonnenburg A, Krapohl B, Zuberbier T, Peiser M, Stahlmann R, et al. Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly. Arch Toxicol. 2018;92:1495-1505 pubmed publisher
    ..25-15 µmol/l, p-phenylenediamine (PPD) 15.6-125 µmol/l, 2-mercaptobenzothiazole (MBT) 50-1000 µmol/l, coumarin, and resorcinol (both: 250-1500 µmol/l)] and four non-sensitizers (monochlorobenzene, ..
  12. Kawaguchi H, Matsumoto I, Osada A, Kurata I, Ebe H, Tanaka Y, et al. Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis. Arthritis Res Ther. 2018;20:66 pubmed publisher
    Anticitrullinated protein antibodies (ACPA) and citrullinated proteins play key roles in the pathogenesis of rheumatoid arthritis (RA)...
  13. Wang W, Anderson L, Nicklay J, Chen H, Gamble M, Shabanowitz J, et al. Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development. Epigenetics Chromatin. 2014;7:22 pubmed publisher
    ..that occur upon the onset of zygotic control of the cell cycle and transcription at the mid-blastula transition (MBT)...
  14. Sakkas L, Bogdanos D, Katsiari C, Platsoucas C. Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment. Autoimmun Rev. 2014;13:1114-20 pubmed publisher
    ..Recent studies suggest that citrullinated antigens are most likely arthritogenic autoantigens in RA. ACPA production is associated with the HLA-DRB1 shared epitope (HLA-DRB1 SE) and accounts for the well-known RA-HLA-DRB1 ..
  15. Birlutiu V, Rezi E, BîrluŢiu R, Zaharie I. A rare association of chronic lymphocytic leukemia with c-ANCA-positive Wegener's granulomatosis: a case report. World J Surg Oncol. 2016;14:145 pubmed publisher
  16. Surmiak M, Kaczor M, Sanak M. Proinflammatory genes expression in granulocytes activated by native proteinase-binding fragments of anti-proteinase 3 IgG. J Physiol Pharmacol. 2015;66:609-15 pubmed
    ..An integrin Mac-1 receptor was postulated to cooperate in neutrophil stimulation by anti-proteinase 3 (anti-PR3). A characteristic profile of transcriptional activation of neutrophils by c-ANCA was described by us previously...
  17. Alam J, Jantan I, Bukhari S. Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy. Biomed Pharmacother. 2017;92:615-633 pubmed publisher
    ..of cytokines, chemokines, autoantibodies like rheumatoid factor (RF) and anticitrullinated protein antibody (ACPA), osteoclastogensis, angiogenesis and systemic consequences like cardiovascular, pulmonary, psychological, and ..
  18. Moxey J, Huq M, Proudman S, Sahhar J, Ngian G, Walker J, et al. Significance of anti-neutrophil cytoplasmic antibodies in systemic sclerosis. Arthritis Res Ther. 2019;21:57 pubmed publisher
    ..ANCA (c-ANCA), perinuclear ANCA (p-ANCA), atypical ANCA, anti-myeloperoxidase (anti-MPO) or anti-proteinase-3 (anti-PR3). Associations of demographic and clinical features with ANCA were investigated by logistic or linear regression...
  19. Valesini G, Gerardi M, Iannuccelli C, Pacucci V, Pendolino M, Shoenfeld Y. Citrullination and autoimmunity. Autoimmun Rev. 2015;14:490-7 pubmed publisher
    ..has been paid to citrullination, because of its role in inducing anti-citrullinated proteins/peptide antibodies (ACPA), a class of autoantibodies with diagnostic, predictive and prognostic value for Rheumatoid Arthritis (RA)...
  20. Stadler K, Mutzenbach J, Kalss G, Sellner J, Al Schameri A, Trinka E, et al. Therapeutic challenges after successful thrombectomy in a patient with an antiphospholipid syndrome associated M1-occlusion: A case report. Interv Neuroradiol. 2015;21:598-602 pubmed publisher
    ..Due to the elevated risk of in-stent thrombosis a prolonged therapy with glycoprotein (GP)IIb/IIIa receptor antagonists in the initial postoperative period and further anticoagulation with coumarin derivate might be needed. ..
  21. Amos Kroohs R, Bloor C, Qureshi M, Vorhees C, Williams M. Effects of developmental exposure to manganese and/or low iron diet: Changes to metal transporters, sucrose preference, elevated zero-maze, open-field, and locomotion in response to fenfluramine, amphetamine, and MK-801. Toxicol Rep. 2015;2:1046-1056 pubmed
    ..Identically treated animals were tested behaviorally at P29 or P60...
  22. Jerrentrup A, Müller T, Mariss J, Dylla S. [Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)]. Internist (Berl). 2018;59:497-504 pubmed publisher
    ..In therapeutic regimens glucocorticoids and/or another immunosuppressant (e. g. cyclophosphamide, methotrexate or azathioprine) are used. The so-called five-factor score is a useful tool for assessment of prognosis. ..
  23. Weiner M, Segelmark M. The clinical presentation and therapy of diseases related to anti-neutrophil cytoplasmic antibodies (ANCA). Autoimmun Rev. 2016;15:978-82 pubmed publisher
    ..These entities are treated quite differently, with therapies ranging from immunosuppressive agents over antibiotics to simply removing the causative drug. A positive ANCA test thus requires a careful diagnostic work-up. ..
  24. Ye Y, Yao S, Wang R, Fang Z, Zhong K, Nie L, et al. PI3K/Akt/NF-κB signaling pathway regulates behaviors in adolescent female rats following with neonatal maternal deprivation and chronic mild stress. Behav Brain Res. 2019;362:199-207 pubmed publisher
    ..open field test (OFT), novel objective recognition test (NORT), Elevated-plus maze (EPM), marble burying test (MBT) and forced swimming test (FST) were performed from PND 42 to PND 50...
  25. Silva L, Black R, Michaelides M, Hurd Y, Dow Edwards D. Sex and age specific effects of delta-9-tetrahydrocannabinol during the periadolescent period in the rat: The unique susceptibility of the prepubescent animal. Neurotoxicol Teratol. 2016;58:88-100 pubmed publisher
    ..Due to differences in timing of puberty in males and females during the P29-38 period of THC treatment, we also dosed female rats between P21-30 (pre-puberty) and male rats between P39-48 (..
  26. Conigliaro P, Chimenti M, Triggianese P, Sunzini F, Novelli L, Perricone C, et al. Autoantibodies in inflammatory arthritis. Autoimmun Rev. 2016;15:673-83 pubmed publisher
    ..major role in determining the development of specific autoantibodies differentiating anti-citrullinated antibodies (ACPA)-positive and negative RA patients...
  27. Grimsby S, Jaensson H, Dubrovska A, Lomnytska M, Hellman U, Souchelnytskyi S. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. FEBS Lett. 2004;577:93-100 pubmed
    ..Interactions of AGP7, sex-determining region Y protein, actin beta and sterol regulatory element binding protein-2 (SREBP-2) proteins ..
  28. Wiedl T, Collaud S, Hillinger S, Arni S, Burgess C, Kroll W, et al. KRAS mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma. Cancer Genomics Proteomics. 2012;9:51-4 pubmed
    ..The results revealed that the activity of myeloblastin was significantly altered in the lung adenocarcinoma biopsies harboring a KRAS gene mutation...
  29. Scheibenbogen C, Letsch A, Thiel E, Schmittel A, Mailaender V, Baerwolf S, et al. CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. Blood. 2002;100:2132-7 pubmed
    ..These data therefore support the immunogenicity of WT1 and proteinase 3 in acute leukemia patients and the potential usefulness of these antigens for leukemia vaccines. ..
  30. Tull S, Bevins A, Kuravi S, Satchell S, Al Ani B, Young S, et al. PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. PLoS ONE. 2012;7:e43916 pubmed publisher
    Neutrophil proteases, proteinase-3 (PR3) and elastase play key roles in glomerular endothelial cell (GEC) injury during glomerulonephritis...
  31. Hughes Austin J, Gan R, Deane K, Weisman M, Demoruelle M, Sokolove J, et al. Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis. Am J Nephrol. 2017;46:481-487 pubmed publisher
    ..associations between RA-related autoantibodies, specifically antibodies to citrullinated protein antigens (ACPA) and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in first-degree relatives of RA patients, who ..
  32. van Heemst J, Trouw L, Nogueira L, van Steenbergen H, van der Helm van Mil A, Allaart C, et al. An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting. Arthritis Res Ther. 2015;17:276 pubmed publisher
    ..arrays have become available that allow the simultaneous analysis of several anti-citrullinated protein antibody (ACPA) reactivities using distinct citrullinated peptides. Such assays are designed for exploratory studies...
  33. Ceccarelli F, Massaro L, Perricone C, Pendolino M, Cipriano E, Truglia S, et al. Jaccoud's arthropathy in systemic lupus erythematosus: clinical, laboratory and ultrasonographic features. Clin Exp Rheumatol. 2017;35:674-677 pubmed
    ..Detection of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) was performed...
  34. Spanuchart I, Zungsontiporn N, O charoen P, Changcharoen B, Bolger D. Granulomatosis with Polyangiitis: A Case of Nasal Mass, Necrotic Lung, and Normal Kidneys. Hawaii J Med Public Health. 2015;74:27-9 pubmed
    ..We emphasize that an initial screening ANCA serology test is recommended in patients with suggestive clinical findings of GPA. Biopsy of an affected organ is paramount for the definitive diagnosis. ..
  35. Ruiz Larrañaga O, Uribarri M, Alcaro M, Escorza Treviño S, del Amo J, Iriondo M, et al. Genetic variants associated with rheumatoid arthritis patients and serotypes in European populations. Clin Exp Rheumatol. 2016;34:236-41 pubmed
    ..loci in an independent European sample and to assess their specificity with anti-citrullinated protein antibodies (ACPA) status...
  36. Ginsberg S, Rosner I, Slobodin G, Boulman N, Rozenbaum M, Kaly L, et al. Etanercept treatment-related c-ANCA-associated large vessel vasculitis. Clin Rheumatol. 2016;35:271-3 pubmed publisher
    ..Awareness of this rare, but serious, adverse event of these commonly used agents in rheumatic diseases is of importance. ..
  37. Wang H, Li Z, Gao F, Zhao J, Zhu M, He X, et al. Immunoprotection of recombinant Eg.P29 against Echinococcus granulosus in sheep. Vet Res Commun. 2016;40:73-9 pubmed publisher
    This study aims to investigate the immunoprotection of recombinant Eg.P29 (rEg.P29) vaccine and analyze the underlying mechanism in sheep. Three groups of male sheep were immunized subcutaneously with rEg...
  38. Díaz Garduño B, Pintado Herrera M, Biel Maeso M, Rueda Márquez J, Lara Martín P, Perales J, et al. Environmental risk assessment of effluents as a whole emerging contaminant: Efficiency of alternative tertiary treatments for wastewater depuration. Water Res. 2017;119:136-149 pubmed publisher
    ..The efficiency of two tertiary treatments, Photobiotreatment (PhtBio) and Multi-Barrier Treatment (MBT), for removing contaminants was determined...
  39. Yokoseki A, Saji E, Arakawa M, Kosaka T, Hokari M, Toyoshima Y, et al. Hypertrophic pachymeningitis: significance of myeloperoxidase anti-neutrophil cytoplasmic antibody. Brain. 2014;137:520-36 pubmed publisher
  40. Bernatsky S, Smargiassi A, Joseph L, Awadalla P, Colmegna I, Hudson M, et al. Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies. Environ Res. 2017;157:60-63 pubmed publisher
    To determine the association of anti-citrullinated antibodies (ACPA) with the ambient air pollutants fine particulate matter (PM2.5) and sulfur dioxide (SO2)...
  41. Hedström A, Stawiarz L, Klareskog L, Alfredsson L. Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case-control study. Eur J Epidemiol. 2018;33:415-423 pubmed publisher
    ..intensity, and cumulative dose of smoking influence the risk of developing anti-citrullinated peptide antibodies (ACPA) positive and ACPA negative RA...
  42. Tony H, Roll P, Mei H, Blümner E, Straka A, Gnuegge L, et al. Combination of B cell biomarkers as independent predictors of response in patients with rheumatoid arthritis treated with rituximab. Clin Exp Rheumatol. 2015;33:887-94 pubmed
    ..Rheumatoid factor (RF), RF-isotypes and anti-citrullinated protein antibodies (ACPA) were also measured...
  43. Fang L, Xu C, Li J, Borggaard O, Wang D. The importance of environmental factors and matrices in the adsorption, desorption, and toxicity of butyltins: a review. Environ Sci Pollut Res Int. 2017;24:9159-9173 pubmed publisher
    ..Due to their widespread use, large amounts of BTs including tributyltin (TBT), dibutyltin (DBT), and monobutyltin (MBT) have entered into the environment, and subsequently causing detrimental effects on humans and aquatic organisms...
  44. Collart C, Smith J, Zegerman P. Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition. Dev Cell. 2017;42:82-96.e3 pubmed publisher
    ..At the mid-blastula transition (MBT), the cell cycle elongates and several processes become established including the onset of bulk transcription and ..
  45. Coux R, Teixeira F, Lehmann R. L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary. Development. 2018;145: pubmed publisher
    ..The tumor suppressor L(3)mbt has been shown to secure cellular identity in Drosophila larval brains by repressing germline-specific genes...
  46. Hafkenscheid L, Bondt A, Scherer H, Huizinga T, Wuhrer M, Toes R, et al. Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans. Mol Cell Proteomics. 2017;16:278-287 pubmed publisher
    ..the unexpectedly high abundance of N-linked glycans on the Fab-domain of Anti-Citrullinated Protein Antibodies (ACPA)...
  47. Nezos A, Cinoku I, Mavragani C, Moutsopoulos H. Antibodies against citrullinated alpha enolase peptides in primary Sjogren's syndrome. Clin Immunol. 2017;183:300-303 pubmed publisher
    ..alpha enolase (CEP-1) has been designated as a major antigenic target of antibodies against citrullinated proteins (ACPA) in patients with rheumatoid arthritis (RA)...
  48. Montejo C, Costa C, Márquez M. Influence of input material and operational performance on the physical and chemical properties of MSW compost. J Environ Manage. 2015;162:240-9 pubmed publisher
    ..In this case, the final composition of MSW compost is related to the performance of the separation process in MBT (Mechanical and Biological Treatment) plants as well as the composition of raw materials and the particular ..
  49. Gomez Vaquero C, Martin I, Loza E, Carmona L, Ivorra J, Narváez J, et al. Effect of Osteoprotegerin and Dickkopf-Related Protein 1 on Radiological Progression in Tightly Controlled Rheumatoid Arthritis. PLoS ONE. 2016;11:e0166691 pubmed publisher
    ..6 ± 1.5 years. Most patients were seropositive for either RF or ACPA, and the large majority (76%) were in remission or had low disease activity. After a median follow-up time of 3...
  50. Kempers A, Nejadnik M, Rombouts Y, Ioan Facsinay A, van Oosterhout M, Jiskoot W, et al. Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for Fc?RI in the pathogenesis of synovial inflammation. Clin Exp Rheumatol. 2018;36:284-293 pubmed
    Anti-citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA)...
  51. Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg M. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J Biol Chem. 2013;288:32979-90 pubmed publisher
    ..We further demonstrate the function of this biased signaling in regulating endothelial cell barrier integrity. ..
  52. Fisher B, Cartwright A, Quirke A, de Pablo P, Romaguera D, Panico S, et al. Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study. BMC Musculoskelet Disord. 2015;16:331 pubmed publisher
    Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response...
  53. Ramos Casado R, Arenales Rivera J, Borjabad García E, Escalada Cuadrado R, Fernández Llorente M, Bados Sevillano R, et al. Classification and characterisation of SRF produced from different flows of processed MSW in the Navarra region and its co-combustion performance with olive tree pruning residues. Waste Manag. 2016;47:206-16 pubmed publisher
    ..The municipal solid waste (MSW) is subjected to a mechanical biological treatment (MBT) in order to stabilize the organic matter and recover the recyclable materials as it is done for packaging wastes...
  54. Terao C, Okada Y, Ikari K, Kochi Y, Suzuki A, Ohmura K, et al. Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population. J Med Genet. 2017;54:853-858 pubmed publisher
    ..We evaluated the non-additive and interactive effects of HLA-DRB1 alleles on RA susceptibility and anticitrullinated protein/peptide antibody (ACPA) levels in Japanese patients.
  55. Thompson S, Yohuno D, Bradley W, Crocombe A. Finite element analysis: a comparison of an all-polyethylene tibial implant and its metal-backed equivalent. Knee Surg Sports Traumatol Arthrosc. 2016;24:2560-6 pubmed publisher
    ..study is that all-polyethylene (APE) tibial implants offer a biomechanical profile similar to metal-backed tray (MBT)...
  56. Cavagna L, Nuño L, Scirè C, Govoni M, Longo F, Franceschini F, et al. Serum Jo-1 Autoantibody and Isolated Arthritis in the Antisynthetase Syndrome: Review of the Literature and Report of the Experience of AENEAS Collaborative Group. Clin Rev Allergy Immunol. 2017;52:71-80 pubmed publisher
    ..of poliarticular involvement, positive rheumatoid factor (RF), or anti-cyclic citrullinated peptide antibodies (ACPA) or evidence of joint erosions at plain radiographs...
  57. Sundareswaran S, Vijayan R. Profile changes following orthodontic treatment of class I bimaxillary protrusion in adult patients of Dravidian ethnicity: A prospective study. Indian J Dent Res. 2017;28:530-537 pubmed publisher
    To prospectively evaluate soft and hard tissue responses to orthodontic treatment of bimaxillary protrusion (BMP) in Dravidian population using McLaughlin, Bennett, and Trevisi (MBT) mechanics of the preadjusted edgewise appliance.
  58. Alonso Rasgado T, Zhang Q, Jimenez Cruz D, Bailey C, Pinder E, Mandaleson A, et al. Evaluation of the performance of three tenodesis techniques for the treatment of scapholunate instability: flexion-extension and radial-ulnar deviation. Med Biol Eng Comput. 2018;56:1091-1105 pubmed publisher
    ..data, we investigated the performance of the Corella, scapholunate axis (SLAM) and modified Brunelli tenodesis (MBT) techniques...
  59. Narváez J, Magallares B, Díaz Torné C, Hernández M, Reina D, Corominas H, et al. Predictive factors for induction of remission in patients with active rheumatoid arthritis treated with tocilizumab in clinical practice. Semin Arthritis Rheum. 2016;45:386-90 pubmed publisher
    ..55, 95% CI: 0.347-0.877). No relationship was found with the neutrophil count or with the RF or ACPA positivity...
  60. Silva J, Carvalho S, Bruzi A, Guimarães R, Oliveira L, Simões L. Genetic diversity among coffee tree progenies Big Coffee VL based on growth traits and production. Genet Mol Res. 2016;15: pubmed publisher
    ..04 to 18.70. The most similar progenies were P23 and P29 and the most dissimilar progenies were G8 and P14...
  61. Lima I, Oliveira R, Cabral M, Atta A, Marchi S, Reis E, et al. Anti-PR3 and anti-MPO antibodies are not present in sera of patients with pulmonary tuberculosis. Rheumatol Int. 2014;34:1231-4 pubmed publisher
    ..Anti-MPO and anti-PR3 antibodies were studied using well-standardized ELISA kits (INOVA Diagnostics, Inc.)...
  62. Castrejón I, Dougados M, Combe B, Fautrel B, Guillemin F, Pincus T. Prediction of Remission in a French Early Arthritis Cohort by RAPID3 and other Core Data Set Measures, but Not by the Absence of Rheumatoid Factor, Anticitrullinated Protein Antibodies, or Radiographic Erosions. J Rheumatol. 2016;43:1285-91 pubmed publisher
    ..by the absence of "poor prognosis RA" indicators, rheumatoid factor (RF), anticitrullinated protein antibodies (ACPA), or radiographic erosions...
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    ..18 million was associated with patients with a high level of anti-citrullinated protein antibodies (ACPA)...
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    Proteinase 3 (PR3), the autoantigen in granulomatosis with polyangiitis, is expressed at the plasma membrane of resting neutrophils, and this membrane expression increases during both activation and apoptosis...
  67. Bahi A. Sustained lentiviral-mediated overexpression of microRNA124a in the dentate gyrus exacerbates anxiety- and autism-like behaviors associated with neonatal isolation in rats. Behav Brain Res. 2016;311:298-308 pubmed publisher
    ..Rats isolated from the dams on PND 1 to PND 11 were assessed for their social interaction, marble burying test (MBT) and repetitive self-grooming behaviors as adults following miR124a overexpression...
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    ..In the case of rituximab, the data indicated a greater probability of clinical benefit in ACPA(+) patients versus ACPA(-) patients, as has been previously described for rheumatoid factor...
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    ..N., Seeger, M., and Nathan, C. F. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 5610-5614) and designated azurophil granule protein 7 (AGP7) and azurocidin...
  70. Khodayar E, Oryan S, Nasehi M, Zarrindast M. Effect of nucleus accumbens shell 5-HT4 receptors on the impairment of ACPA-induced emotional memory consolidation in male Wistar rats. Behav Pharmacol. 2016;27:12-21 pubmed publisher
    ..Intra-NAc shell administration of ACPA (selective cannabinoid CB1 receptor agonist 0.006 µg/rat) and RS23597 (5-HT4 receptor antagonist 0...
  71. Butova T, Zaitseva S, Butov D, Stepanenko G. Morphological changes in experimental tuberculosis resulting from treatment with quercetin and polyvinylpyrrolidone. Int J Mycobacteriol. 2016;5 Suppl 1:S103-S104 pubmed publisher
    ..divided into five groups (Group 1-5), with six to seven mice in each group: Group 1, Mycobacterium tuberculosis (MBT)-uninfected mice; Group 2, MBT-infected mice; Group 3, MBT infected and treated with anti-TB preparation (ATP); ..
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    The biological functions of human neutrophil protease 3 (Pr3) differ from those of neutrophil elastase despite their close structural and functional resemblance...
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    ..Instead, caspase-3 activation was mediated by serine protease proteinase 3 (PR3), which is present in the cytosol of aging neutrophils...
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    ..miR-146a, and miR-let-7e in patients with bilateral knee osteoarthritis (OA) after a cycle of mud-bath therapy (MBT). Thirty-two patients with knee OA defined by the ACR criteria were included...
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    ..In this work, a lysimeter was used to simulate how refuse from mechanical-biological treatment (MBT) plants evolved in a landfill over a 45-day period...
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    ..arginine deiminase (PPAD), which citrullinates arginine residues of proteins, thus forming neoantigens that lead to ACPA production...
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    ..speed (5, 10, and 20 m); modified 5-0-5 agility test; countermovement jump (CMJ); overhead medicine ball throw (MBT); and serve velocity (SV)...
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    Anti-citrullinated protein antibodies (ACPA) have been shown to cause platelet activation in vitro, through the low-affinity immunoglobulin G (IgG) receptor (Fc?RIIa) on platelets...
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    The target antigen of anti-neutrophil cytoplasm antibodies (ACPA; also known as ANCA) was isolated by affinity chromatography from supernatants of human neutrophils, stimulated with phorbol ester to induce degranulation...
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    ..b>Wegener autoantigen interacts with a "gateway" receptor (PAR-2) on iDCs in vitro triggering their maturation and ..
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    ..membrane proteinase 3 (mPR3) expression during TNF-alpha-induced adhesion of neutrophils in the presence of anti-PR3 antibodies, a situation occurring during anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitis...
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    ..IIF) and confirm cytoplasmic (C-ANCA) and perinuclear (P-ANCA) staining with ELISAs for proteinase 3 (PR3) and myeloperoxidase (MPO) specificities...
  89. Ramos González P, Chabi Jesus C, Guerra Peraza O, Breton M, Arena G, Nunes M, et al. Phylogenetic and Molecular Variability Studies Reveal a New Genetic Clade of Citrus leprosis virus C. Viruses. 2016;8: pubmed publisher
    ..This study reveals the molecular variability of the virus by analyzing four genomic regions (p29, p15, MP and RNA2-intergenic region) distributed over its two RNAs...
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    ..Post-training microinjection of a cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA; 2.5-7.5ng/rat) into the VH (intra-VH) induced amnesia...
  91. Rossi F, Molnar C, Hashiyama K, Heinen J, Pampalona J, Llamazares S, et al. An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth. Open Biol. 2017;7: pubmed publisher
    ..Most of these target genes are not significantly overexpressed in mbt tumours hence showing that, rather counterintuitively, tumour-linked overexpression is not a good predictor of ..
  92. Cole R, Mills G, Hale M, Parker R, Bolam T, Teasdale P, et al. Development and evaluation of a new diffusive gradients in thin-films technique for measuring organotin compounds in coastal sediment pore water. Talanta. 2018;178:670-678 pubmed publisher
    ..for diffusive gradients in thin-films (DGT) adsorption gels to pre-concentrate five organotins (monobutlytin (MBT), dibutyltin (DBT), tributyltin (TBT), diphenyltin (DPhT), triphenyltin (TPhT)) found frequently in coastal ..