PRSS2

Summary

Gene Symbol: PRSS2
Description: serine protease 2
Alias: TRY2, TRY8, TRYP2, trypsin-2, anionic trypsinogen, protease serine 2 preproprotein, protease, serine 2, protease, serine, 2 (trypsin 2), trypsin II, trypsinogen 2
Species: human
Products:     PRSS2

Top Publications

  1. Paju A, Sorsa T, Tervahartiala T, Koivunen E, Haglund C, Leminen A, et al. The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation. Br J Cancer. 2001;84:1363-71 pubmed
    ..These results suggest that trypsin may play a role in the regulation of the MMP-dependent proteolysis associated with invasion and metastasis of ovarian cancer. ..
  2. Masson E, Le Maréchal C, Delcenserie R, Chen J, Ferec C. Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation. Hum Genet. 2008;123:521-9 pubmed publisher
    ..Here we demonstrate a heterozygous hybrid PRSS2 (encoding anionic trypsinogen)/PRSS1 gene in a French white family with hereditary pancreatitis, by means of quantitative fluorescent ..
  3. Andersen A, Novovic S, Ersbøll A, Jorgensen L, Hansen M. Urinary trypsinogen-2 dipstick in acute pancreatitis. Pancreas. 2010;39:26-30 pubmed publisher
    ..However, the test demonstrated an adequate sensitivity to be used for rapid early screening of AP in daily clinics. ..
  4. Díaz Peromingo J, Alban A, Pesqueira P, Molinos S, Gayol M. [Usefulness of determining urinary trypsinogen-2 in diagnosis and prognosis of patients with acute pancreatitis]. An Sist Sanit Navar. 2009;32:343-50 pubmed
    ..032; r=0.814). Testing urinary trypsinogen-2 in patients with AP is rapid and useful. Patients over the age of 65 with hypoxia, metabolic acidosis and hypocalcemia tend to present a prolonged average hospital stay and higher mortality. ..
  5. Williams S, Gotley D, Antalis T. Human trypsinogen in colorectal cancer. Int J Cancer. 2001;93:67-73 pubmed
    ..by human colorectal tumor tissues compared with adjacent normal colonic mucosa identified an isoform of TRY (TRY2) up-regulated in colorectal cancers...
  6. Moilanen M, Sorsa T, Stenman M, Nyberg P, Lindy O, Vesterinen J, et al. Tumor-associated trypsinogen-2 (trypsinogen-2) activates procollagenases (MMP-1, -8, -13) and stromelysin-1 (MMP-3) and degrades type I collagen. Biochemistry. 2003;42:5414-20 pubmed
  7. Stenman M, Ainola M, Valmu L, Bjartell A, Ma G, Stenman U, et al. Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. Am J Pathol. 2005;167:1119-24 pubmed
    ..Thus, trypsin-2 and its regulators should be further studied for use as markers of prognosis and disease activity in rheumatoid arthritis. ..
  8. Sorsa T, Salo T, Koivunen E, Tyynela J, Konttinen Y, Bergmann U, et al. Activation of type IV procollagenases by human tumor-associated trypsin-2. J Biol Chem. 1997;272:21067-74 pubmed
    ..The ability of human tumor cell-derived trypsin-2 to activate latent MMPs suggests a role for trypsin-2 in initiating the proteinase cascade that mediates tumor invasion and metastasis formation. ..
  9. Witt H, Sahin Toth M, Landt O, Chen J, Kahne T, Drenth J, et al. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet. 2006;38:668-73 pubmed
    ..activity owing to mutated PRSS1 enhances the risk for chronic pancreatitis, mutations in the gene encoding anionic trypsinogen (PRSS2) may also predispose to disease...

More Information

Publications104 found, 100 shown here

  1. Masson E, Le Maréchal C, Chandak G, Lamoril J, Bezieau S, Mahurkar S, et al. Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis. Clin Gastroenterol Hepatol. 2008;6:82-8 pubmed
    ..approximately 605 kilobase segment containing the PRSS1 (encoding cationic trypsinogen) and PRSS2 (encoding anionic trypsinogen) genes causes hereditary pancreatitis...
  2. Shan L, Ji T, Su X, Shao Q, Du T, Zhang S. TMPRSS2-ERG Fusion Promotes Recruitment of Regulatory T cells and Tumor Growth in Prostate Cancer. Am J Med Sci. 2018;356:72-78 pubmed publisher
    ..TMPRSS2-ERG fusion can regulate the recruitment and infiltration of regulatory T cells to promote tumor growth in prostate cancer. ..
  3. Marques R, Aghai A, de Ridder C, Stuurman D, Hoeben S, Boer A, et al. High Efficacy of Combination Therapy Using PI3K/AKT Inhibitors with Androgen Deprivation in Prostate Cancer Preclinical Models. Eur Urol. 2015;67:1177-1185 pubmed publisher
    ..This preclinical study illustrates the potent anticancer activity of novel PTEN-targeted drugs on PCa models, particularly in combination with hormonal therapy. ..
  4. He J, Sun X, Shi T, Schepmoes A, Fillmore T, Petyuk V, et al. Antibody-independent targeted quantification of TMPRSS2-ERG fusion protein products in prostate cancer. Mol Oncol. 2014;8:1169-80 pubmed publisher
    ..The PRISM-SRM assays provide valuable tools for studying TMPRSS2-ERG gene fusion protein products in prostate cancer. ..
  5. Momeni L, Shareghi B, Farhadian S, Vaziri S, Saboury A, Raisi F. A molecular simulation and spectroscopic approach to the binding affinity between trypsin and 2-propanol and protein conformation. Int J Biol Macromol. 2018;119:477-485 pubmed publisher
    ..Upon 2-propanol conjugation, the residual activity of the enzyme was increased. 2-propanol, therefore, acted as a stabilizer and activator for trypsin. ..
  6. Lin J, Zhao D, Wang J, Wang Y, Li H, Yin X, et al. Transcriptome changes upon in vitro challenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows. Vet Immunol Immunopathol. 2015;163:146-56 pubmed publisher
    ..For macrophages, kallikrein-related peptidase 12 (KLK12) and protease, serine, 2 (trypsin 2) (PRSS2), as well as a secreted protein, acidic, cysteine-rich (osteonectin) (SPARC)-centered matricellular gene ..
  7. Burdelski C, Barreau Y, Simon R, Hube Magg C, Minner S, Koop C, et al. Saccharomyces cerevisiae-like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion-positive and fusion-negative cancers. Hum Pathol. 2015;46:514-23 pubmed publisher
    ..In conclusion, our data suggest a markedly different role of SEC14L1 in TMPSSR2:ERG-negative and TMPSSR2:ERG-positive prostate cancers. ..
  8. Yilmaz O, Berber U, Okcelik S, Soydan H, Ates F, Karademir K. TMPRSS2-ERG gene fusion in Turkish patients with localized prostate cancer: results of radical prostatectomy specimens. Turk J Urol. 2016;42:60-3 pubmed publisher
    ..049). The incidence of TMPRSS-ERG fusion in patients with localised prostate cancer in our study with Turkish population was found as 46.5%. Only tumor stage correlated with TMPRSS2-ERG fusion. ..
  9. Purayil H, Zhang Y, Dey A, Gersey Z, España Serrano L, Daaka Y. Arrestin2 modulates androgen receptor activation. Oncogene. 2015;34:3144-51 pubmed publisher
    ..These results illustrate a new role for Arr2 in the expression and activation of AR and its potential relevance as a target for therapeutic intervention and monitoring of disease progression. ..
  10. Esumi M, Ishibashi M, Yamaguchi H, Nakajima S, Tai Y, Kikuta S, et al. Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection. Hepatology. 2015;61:437-46 pubmed publisher
    ..Host transmembrane serine proteases may be involved in the sensitivity, persistence, and pathogenesis of HCV infection and be possible targets for antiviral therapy. ..
  11. Sofia V, Surace C, Terlizzi V, Da Sacco L, Alghisi F, Angiolillo A, et al. Trans-heterozygosity for mutations enhances the risk of recurrent/chronic pancreatitis in patients with Cystic Fibrosis. Mol Med. 2018;24:38 pubmed publisher
    ..We tested a panel of 8 genes involved in the IPAT, i.e. PRSS1, PRSS2, SPINK1, CTRC, CASR, CFTR, CTSB and KRT8 and 23 additional genes implicated in the PSP...
  12. Nahm C, Brown K, Townend P, Colvin E, Howell V, Gill A, et al. Acinar cell density at the pancreatic resection margin is associated with post-pancreatectomy pancreatitis and the development of postoperative pancreatic fistula. HPB (Oxford). 2018;20:432-440 pubmed publisher
    ..81, 95%CI 2.17-145.9, p = 0.001). The development of POPF may involve a complex interaction between acinar cell density, immediate leakage of pancreatic fluid, and postoperative pancreatitis. ..
  13. Singh N, Gupta D, Sharma S, Sahu D, Mishra A, Yadav D, et al. Single-nucleotide and copy-number variance related to severity of hypospadias. Pediatr Surg Int. 2018;34:991-1008 pubmed publisher
    ..On aggregate analysis with p?<?0.001, we identified homozygous-loss of Ch7:q34 (PRSS3P2, PRSS2)...
  14. Knuuttila M, Mehmood A, Mäki Jouppila J, Ryberg H, Taimen P, Knaapila J, et al. Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer. Endocr Relat Cancer. 2018;25:807-819 pubmed publisher
    ..Thus, patients with TMPRSS2-ERG-positive prostate cancer may benefit from novel inhibitors targeting the alternative DHT biosynthesis. ..
  15. Han S, Lee C, Trevino J, Hughes S, Sarosi G. Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma. PLoS ONE. 2013;8:e76667 pubmed publisher
    ..PAR-2 activation increases cancer cell proliferation, and promotes cancer cell survival. Targeting the trypsin activated PAR-2 pathway in conjunction with current chemotherapeutic agents may be a viable therapeutic strategy in EA. ..
  16. Hachero Cruzado I, Rodríguez Rua A, Román Padilla J, Ponce M, Fernández Díaz C, Manchado M. Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels. Comp Biochem Physiol Part D Genomics Proteomics. 2014;12:61-73 pubmed publisher
    ..In contrast, larvae fed LTAG showed higher mRNA levels of several pancreatic enzymes (try1a, try2, cela1, cela3, cela4, chym1, chym2, amy2a and pnlip) and appetite modulators (agrp1) and some intra- and ..
  17. Pettersson A, Graff R, Bauer S, Pitt M, Lis R, Stack E, et al. The TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2012;21:1497-509 pubmed publisher
    ..This is the largest prospective cohort study to examine associations of ERG overexpression and lethal prostate cancer among men treated with radical prostatectomy. ..
  18. Weiss F, Hesselbarth N, Párniczky A, Mosztbacher D, Lämmerhirt F, Ruffert C, et al. Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis. Pancreatology. 2018;: pubmed publisher
    ..Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP...
  19. Abou Ouf H, Zhao L, Bismar T. ERG expression in prostate cancer: biological relevance and clinical implication. J Cancer Res Clin Oncol. 2016;142:1781-93 pubmed publisher
    ..Elucidation of the mechanisms of ERG gene rearrangements and expression promises novel therapeutic and diagnostic avenues for prostate cancer. ..
  20. Sanguedolce F, Cormio A, Brunelli M, D Amuri A, Carrieri G, Bufo P, et al. Urine TMPRSS2: ERG Fusion Transcript as a Biomarker for Prostate Cancer: Literature Review. Clin Genitourin Cancer. 2016;14:117-21 pubmed publisher
    ..Should these findings be confirmed in larger studies, urinary TMPRSS2:ERG might become a valuable test not only for diagnosing PCa but also for distinguishing the aggressive tumors from the indolent ones. ..
  21. Jancsó Z, Sahin Toth M. Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis. J Biol Chem. 2016;291:12897-905 pubmed publisher
    The human pancreas expresses two major trypsinogen isoforms, cationic trypsinogen (PRSS1) and anionic trypsinogen (PRSS2)...
  22. Todorova K, Metodiev M, Metodieva G, Mincheff M, Fernandez N, Hayrabedyan S. Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer. Horm Cancer. 2017;8:28-48 pubmed publisher
    ..In summary, miR-204 is a mild regulator of the AR function during the phase of preserved AR sensitivity as the latter one is required for ERG-fusion translocation. ..
  23. Merdan S, Tomlins S, Barnett C, Morgan T, Montie J, Wei J, et al. Assessment of long-term outcomes associated with urinary prostate cancer antigen 3 and TMPRSS2:ERG gene fusion at repeat biopsy. Cancer. 2015;121:4071-9 pubmed publisher
    ..The use of PCA3 or T2:ERG testing for repeat biopsy decisions can substantially reduce the number of biopsies without significantly affecting 10-year survival. ..
  24. Yamamoto M, Matsuyama S, Li X, Takeda M, Kawaguchi Y, Inoue J, et al. Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay. Antimicrob Agents Chemother. 2016;60:6532-6539 pubmed publisher
    ..Nafamostat also blocked MERS-CoV infection in vitro Our assay has the potential to facilitate the discovery of new inhibitors of membrane fusion of MERS-CoV as well as other viruses that rely on the activity of TMPRSS2. ..
  25. O Malley P, Nguyen D, Al Hussein Al Awamlh B, Wu G, Thompson I, Sanda M, et al. Racial Variation in the Utility of Urinary Biomarkers PCA3 and T2ERG in a Large Multicenter Study. J Urol. 2017;198:42-49 pubmed publisher
    ..The post hoc subgroup analysis nature of the study limited findings to being hypothesis generating. As novel biomarkers are discovered, clinical utility should be established across demographically diverse cohorts. ..
  26. Garten W, Braden C, Arendt A, Peitsch C, Baron J, Lu Y, et al. Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics. Eur J Cell Biol. 2015;94:375-83 pubmed publisher
    ..Their ubiquitous presence in the organism allows a systemic virus infection. Peptidomimetic inhibitors derived from the HA cleavage site inhibit the HA-activating proteases and thus virus propagation. ..
  27. Bkhairia I, Ben Khaled H, Ktari N, Miled N, Nasri M, Ghorbel S. Biochemical and molecular characterisation of a new alkaline trypsin from Liza aurata: Structural features explaining thermal stability. Food Chem. 2016;196:1346-54 pubmed publisher
    ..It encodes a protein of 222 amino acids, having only 86% of identity with its most homologous trypsin II of the Salmo salar. A phylogenic analysis showed that L. aurata trypsin (LAT) is close to fish enzymes...
  28. Dondoo T, Fukumori T, Daizumoto K, Fukawa T, Kohzuki M, Kowada M, et al. Galectin-3 Is Implicated in Tumor Progression and Resistance to Anti-androgen Drug Through Regulation of Androgen Receptor Signaling in Prostate Cancer. Anticancer Res. 2017;37:125-134 pubmed
    ..These results suggest that galectin-3 is a potential target molecule for future treatment of anti-androgen drug-resistant prostate cancer. ..
  29. Fallahabadi Z, Noori Daloii M, Mahdian R, Behjati F, Shokrgozar M, Abolhasani M, et al. Frequency of PTEN alterations, TMPRSS2-ERG fusion and their association in prostate cancer. Gene. 2016;575:755-60 pubmed publisher
    ..While the majority of PCA samples harbor TMPRSS2-ERG fusion as well as PTEN gene deletion, normal tissues do not show these molecular aberrations. ..
  30. Laporte M, Naesens L. Airway proteases: an emerging drug target for influenza and other respiratory virus infections. Curr Opin Virol. 2017;24:16-24 pubmed publisher
    ..Though still in its infancy, airway protease inhibition represents an attractive host-cell targeting approach to combat respiratory viruses such as influenza. ..
  31. Eryilmaz I, Kordan Y, Vuruşkan B, Kaygisiz O, Tunca B, Cecener G. T2E (TMPRSS2-ERG) fusion transcripts are associated with higher levels of AMACR mRNA and a subsequent prostate cancer diagnosis in patients with atypical small acinar proliferation. Gene. 2018;645:69-75 pubmed publisher
  32. Ghilardi C, Silini A, Figini S, Anastasia A, Lupi M, Fruscio R, et al. Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2. Oncotarget. 2015;6:28389-400 pubmed publisher
    ..human endothelial cells (EC) express the trypsinogen 4 isoform of the serine protease 3 (PRSS3), and lack both PRSS2 and PRSS1...
  33. Sousa L, Mendes G, Campos D, Baruselli P, Papa P. Equine Chorionic Gonadotropin Modulates the Expression of Genes Related to the Structure and Function of the Bovine Corpus Luteum. PLoS ONE. 2016;11:e0164089 pubmed publisher
    ..effect of stimulatory and superovulatory treatments on gene and protein expression of ANG, ANGPT1, NOS2, ADM, PRSS2, MMP9 and PLAU. Serum insulin did not differ among groups (P = 0.96)...
  34. Shirato K, Kanou K, Kawase M, Matsuyama S. Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. J Virol. 2017;91: pubmed
    ..Therefore, therapeutic agents for coronavirus-mediated diseases, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), should target cell surface TMPRSS2 rather than endosomal cathepsin. ..
  35. Mannan R, Bhasin T, Manjari M, Singh G, Bhatia P, Sharma S. Immunohistochemical expression of Ets-related gene-transcriptional factor in adenocarcinoma prostate and its correlation with Gleason score. Indian J Pathol Microbiol. 2016;59:489-495 pubmed publisher
    ..ERG expression was found in 58% patients. An increase in the ERG expression was observed with an increase in Gleason score. The intensity of ERG expression, however, decreased with an increasing Gleason score. ..
  36. Hayashi K, Hosoe M, Kizaki K, Fujii S, Kanahara H, Takahashi T, et al. Differential gene expression profiling of endometrium during the mid-luteal phase of the estrous cycle between a repeat breeder (RB) and non-RB cows. Reprod Biol Endocrinol. 2017;15:20 pubmed publisher
    ..combining the data above four endometrial compartments), RB cows showed up-regulation of 37 genes including PRSS2, GSTA3 and PIPOX and down-regulation of 39 genes including CHGA, KRT35 and THBS4 when compared with non-RB cows...
  37. Lu L, Zhang H, Pang J, Hou G, Lu M, Gao X. ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer. Oncol Lett. 2016;11:2532-2538 pubmed
    ..923%; specificity, 71.429%; 95% CI for AUC, 0.724-0.958). In addition, a high Gleason score (?7) and a cT2c classification upon biopsy were independent factors for EPE. ..
  38. Lázaro Ibáñez E, Lunavat T, Jang S, Escobedo Lucea C, Oliver De La Cruz J, Siljander P, et al. Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines. BMC Cancer. 2017;17:92 pubmed publisher
  39. Kukor Z, Toth M, Sahin Toth M. Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem. 2003;270:2047-58 pubmed
    Human pancreatic secretions contain two major trypsinogen isoforms, cationic and anionic trypsinogen, normally at a ratio of 2 : 1...
  40. Setlur S, Mertz K, Hoshida Y, Demichelis F, Lupien M, Perner S, et al. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst. 2008;100:815-25 pubmed publisher
    ..63- vs 1.0-fold, difference = 4.63-fold, 95% CI = 4.34- to 4.92-fold). TMPRSS2-ERG fusion prostate cancer is a distinct molecular subclass. TMPRSS2-ERG expression is regulated by a novel ER-dependent mechanism. ..
  41. Graff R, Pettersson A, Lis R, Ahearn T, Markt S, Wilson K, et al. Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression. Am J Clin Nutr. 2016;103:851-60 pubmed publisher
    ..In particular, tomato sauce consumption may play a role in reducing TMPRSS2:ERG-positive disease. ..
  42. Berg K. The prognostic and predictive value of TMPRSS2-ERG gene fusion and ERG protein expression in prostate cancer biopsies. Dan Med J. 2016;63: pubmed
  43. Bjartell A, Paju A, Zhang W, Gadaleanu V, Hansson J, Landberg G, et al. Expression of tumor-associated trypsinogens (TAT-1 and TAT-2) in prostate cancer. Prostate. 2005;64:29-39 pubmed
    ..Further studies on the role of TAT in invasive PCa and on the mechanisms involved in the regulation of TAT expression are warranted. ..
  44. Vercaigne Marko D, Carrere J, Guy Crotte O, Figarella C, Hayem A. Human cationic and anionic trypsins: differences of interaction with alpha 1-proteinase inhibitor. Biol Chem Hoppe Seyler. 1989;370:1163-71 pubmed
    Human cationic (trypsin 1) and anionic (trypsin 2) trypsins were obtained by controlled activation of purified trypsinogens 1 and 2, respectively...
  45. Pasternak A, White A, Jeffery C, Medina N, Cahoon M, Ringe D, et al. The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity. Protein Sci. 2001;10:1331-42 pubmed
    ..Together, these data illustrate that induced fit does not generally contribute to enzyme specificity. ..
  46. Cevik Y, Kavalci C, Ozer M, Daş M, Kiyak G, Ozdogan M. The role of urine trypsinogen-2 test in the differential diagnosis of acute pancreatitis in the Emergency Department. Ulus Travma Acil Cerrahi Derg. 2010;16:125-9 pubmed
  47. Uemura K, Murakami Y, Sudo T, Hashimoto Y, Nakashima A, Yamaoka E, et al. Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. Pancreas. 2012;41:876-81 pubmed publisher
    Previous reports suggested that the urine trypsinogen 2 (U-TRP2) test might be a valuable method for the diagnosis of postoperative pancreatitis after pancreatic surgery...
  48. Whitcomb D, Larusch J, Krasinskas A, Klei L, Smith J, Brand R, et al. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012;44:1349-54 pubmed publisher
    ..We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 (P < 1 × 10(-12)) and X-linked CLDN2 (P < 1 × 10(-21)) through a two-stage genome-wide study (stage 1: 676 ..
  49. Figarella C, Negri G, Guy O. The two human trypsinogens. Inhibition spectra of the two human trypsins derived from their purified zymogens. Eur J Biochem. 1975;53:457-63 pubmed
    ..b>Trypsin 2 was completely inhibited in a one-to-one molar ratio while trypsin 1 was poorly inhibited...
  50. Teich N, Le Maréchal C, Kukor Z, Caca K, Witzigmann H, Chen J, et al. Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2). Hum Mutat. 2004;23:22-31 pubmed
    The human pancreas secretes two major trypsinogen isoforms, cationic and anionic trypsinogen. To date, 19 genetic variants have been identified in the cationic trypsinogen gene (PRSS1) of patients with hereditary, familial, or sporadic ..
  51. Sundaresan S, Chacko A, Dutta A, Bhatia E, Witt H, Te Morsche R, et al. Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. Pancreatology. 2009;9:145-9 pubmed publisher
    ..The trypsin inhibitor (SPINK1) N34S variant partially explains the genetic susceptibility to TCP. As anionic trypsinogen (PRSS2) G191R protects against chronic pancreatitis in Europeans, we investigated whether this variant ..
  52. Kume K, Masamune A, Takagi Y, Kikuta K, Watanabe T, Satoh K, et al. A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders. Gut. 2009;58:820-4 pubmed publisher
    ..It has been recently shown that a loss-of-function variant, c.571G>A (p.G191R), in the anionic trypsinogen (PRSS2) gene protects against chronic pancreatitis in European populations...
  53. Gao J, Zhu F, Lv S, Li Z, Ling Z, Gong Y, et al. Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. Oncol Rep. 2010;23:1683-92 pubmed
    ..Two proteins were up-regulated, serine proteinase-2 (PRSS2) preproprotein and pancreatic lipase-related protein-1 (PLRP1), and two proteins were down-regulated, ..
  54. Tseng C, Chen C, Lin S, Chang F, Lin H, Lee S. Rapid urinary trypsinogen-2 test strip in the diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography. Pancreas. 2011;40:1211-4 pubmed publisher
    ..A negative urinary dipstick test at 3 hours after the procedure rules out post-ERCP pancreatitis with a high probability and allows of early discharge plan. ..
  55. Adamo P, Porazinski S, Rajatileka S, Jumbe S, Hagen R, Cheung M, et al. The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells. Oncol Lett. 2017;14:5605-5610 pubmed publisher
    ..ERG overexpression reduced endogenous PTEN expression, whereas ERG knockdown increased PTEN expression. The ability of ERG to repress PTEN may contribute to a more cancer-permissive environment...
  56. Pujante I, Moyano F, Martos Sitcha J, Mancera J, Martinez Rodriguez G. Effect of different salinities on gene expression and activity of digestive enzymes in the thick-lipped grey mullet (Chelon labrosus). Fish Physiol Biochem. 2018;44:349-373 pubmed publisher
    The effects of different environmental salinities (0, 12, 40, and 55 ppt) on pepsinogen 2 (pga2), trypsinogen 2 (try2), chymotrypsinogen (ctr), and pancreatic alpha-amylase (amy2a) gene expression, and on the total activities of their ..
  57. Pollard S, Meier W, Chow P, Rosa J, Wiley D. CD4-binding regions of human immunodeficiency virus envelope glycoprotein gp120 defined by proteolytic digestion. Proc Natl Acad Sci U S A. 1991;88:11320-4 pubmed
  58. Perona J, Tsu C, McGrath M, Craik C, Fletterick R. Relocating a negative charge in the binding pocket of trypsin. J Mol Biol. 1993;230:934-49 pubmed
    ..This structural flexibility may be of critical importance to the retention of catalytic activity by the variant enzyme. ..
  59. Baptista A, Jonson P, Hough E, Petersen S. The origin of trypsin: evidence for multiple gene duplications in trypsins. J Mol Evol. 1998;47:353-62 pubmed
    ..This ancestral trypsin gene was subsequently duplicated, leading to the earliest version of a full-sized trypsin, from which the contemporary trypsins have developed. ..
  60. Teich N, Nemoda Z, Kohler H, Heinritz W, Mossner J, Keim V, et al. Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl. Hum Mutat. 2005;25:343-7 pubmed
    ..The recombination replaced at least 289 nucleotides with the paralogous sequence from the anionic trypsinogen gene (serine protease 2; PRSS2), and resulted in the PRSS1 mutations c.86A > T and c...
  61. Lempinen M, Isoniemi H, Makisalo H, Nordin A, Halme L, Arola J, et al. Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures. J Hepatol. 2007;47:677-83 pubmed
    ..759. Our results suggest that serum trypsinogen-2 is a most useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA. ..
  62. Vilen S, Nyberg P, Hukkanen M, Sutinen M, Ylipalosaari M, Bjartell A, et al. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. Exp Cell Res. 2008;314:914-26 pubmed
  63. Santhosh S, Witt H, Te Morsche R, Nemoda Z, Molnar T, Pap A, et al. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. Pancreas. 2008;36:317-20 pubmed publisher
  64. Kobayashi K, Sasaki T, Serikawa M, Inoue M, Itsuki H, Chayama K. Assessment of trypsinogen-2 levels as an early diagnostic for post-endoscopic retrograde cholangiopancreatography pancreatitis. Pancreas. 2011;40:1206-10 pubmed publisher
    ..These results suggest that TRY-2 is a more sensitive marker than amylase, and it can be useful in early diagnosis of post-ERCP pancreatitis. ..
  65. Avanthi S, Ravi Kanth V, Agarwal J, Lakhtakia S, Gangineni K, Rao G, et al. Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India. J Gastroenterol Hepatol. 2015;30:1796-801 pubmed publisher
    ..In this study, we evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic RAP and CP...
  66. Zhou C, Young D, Yeboah E, Coburn S, Tettey Y, Biritwum R, et al. TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and a Meta-Analysis of Racial Differences. Am J Epidemiol. 2017;186:1352-1361 pubmed publisher
    ..The lower prevalence of TMPRSS2:ERG fusions in men of African descent implies that alternative genomic mechanisms might explain the disproportionately high prostate cancer burden in such populations. ..
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    ..in the Chymotrypsin C gene (CTRC) it became clear that also protective genetic variants exist in the anionic trypsinogen gene (PRSS2) that decrease susceptibility for pancreatitis...
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    ..2% and 7.63, respectively. This simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis. ..
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    ..A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1-PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2-MORC4 loci (rs7057398 in RIPPLY1 and ..
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    The kinetic investigation of the inhibition of human pancreatic trypsin 1, trypsin 2 and chymotrypsin A by mucus proteinase inhibitor, eglin c and aprotinin reveals that (i) the first protein is a potent inhibitor of chymotrypsin A (kass...
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    ..457G>C) in the PRSS2 (serine protease 2, human anionic trypsinogen) gene, which changed Asp(153) to a histidine residue (p.D153H). The p...
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    ..Experimental studies have suggested that trypsinogen may enhance tumor progression and that the ratio between anionic trypsinogen and cationic trypsinogen (HAT/HCT) and between the sum of trypsinogens and pancreatic secretory trypsin ..
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    ..Urinary trypsinogen-2 (UT-2) has been increasingly used but its clinical value for the diagnosis of acute pancreatitis and post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis has not yet been systematically assessed...
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    ..Mutations in EGFR and its downstream pathway, as well as mutations that affect tumor cell function, are related to primary resistance. Somatic single-nucleotide mutation patterns might be associated with primary resistance to EGFR TKIs. ..
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    ..These results suggest that circulating HCoVs in the field generally use cell-surface TMPRSS2 for cell entry, not endosomal cathepsins, in human airway epithelial cells. ..
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