Gene Symbol: PRRG4
Description: proline rich and Gla domain 4
Alias: PRGP4, TMG4, transmembrane gamma-carboxyglutamic acid protein 4, proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane), proline rich Gla 4 (transmembrane) isoform 1, proline rich Gla 4 (transmembrane) isoform 2, proline rich Gla 4 (transmembrane) isoform 3, proline-rich Gla protein 4, proline-rich gamma-carboxyglutamic acid protein 4
Latourelle J, Pankratz N, Dumitriu A, Wilk J, Goldwurm S, Pezzoli G, et al
. Genomewide association study for onset age in Parkinson disease. BMC Med Genet. 2009;10:98 pubmed publisher
..On chromosome 11, the SNP with the lowest p-value (rs10767971; p = 5.4 x 10(-7)) lies between the genes QSER1 and PRRG4. Near the PARK3 linkage region on chromosome 2p13, association was observed with a SNP (rs7577851; p = 8...
Kulman J, Harris J, Xie L, Davie E. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. Proc Natl Acad Sci U S A. 2001;98:1370-5 pubmed
..the cloning of the cDNAs for two additional human transmembrane Gla proteins (TMG) of 20-24 kDa named TMG3 and TMG4. These two proteins possess extracellular Gla domains with 13 or 9 potential Gla residues, respectively, followed ..
Justice E, Barnum S, Kidd T. The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene. PLoS Genet. 2017;13:e1006865 pubmed publisher
..WAGR is caused by a chromosomal deletion that includes the PAX6, WT1 and PRRG4 genes...
Yazicioglu M, Monaldini L, Chu K, Khazi F, Murphy S, Huang H, et al
. Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2. J Biol Chem. 2013;288:25908-14 pubmed publisher
..We screened WW domain arrays for cytosolic binding partners for PRRG4 and identified novel protein-protein interactions for the protein...
Yamamoto T, Togawa M, Shimada S, Sangu N, Shimojima K, Okamoto N. Narrowing of the responsible region for severe developmental delay and autistic behaviors in WAGR syndrome down to 1.6?Mb including PAX6, WT1, and PRRG4. Am J Med Genet A. 2014;164A:634-8 pubmed publisher
..Thus, the unique genotype identified in this study suggested that haploinsufficiencies of PAX6 or PRRG4 included in this region are candidate genes for severe developmental delay and autistic features characteristic of ..
Justice E, Barnum S, Kidd T. Correction: The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene. PLoS Genet. 2017;13:e1007061 pubmed publisher
..This corrects the article DOI: 10.1371/journal.pgen.1006865.]...