Prox1

Summary

Gene Symbol: Prox1
Description: prospero homeobox 1
Alias: prospero homeobox protein 1, homeobox prospero-like protein PROX1, prospero-related homeobox 1
Species: human
Products:     Prox1

Top Publications

  1. Lecompte S, Pasquetti G, Hermant X, Grenier Boley B, Gonzalez Gross M, De Henauw S, et al. Genetic and molecular insights into the role of PROX1 in glucose metabolism. Diabetes. 2013;62:1738-45 pubmed publisher
    Genome-wide association studies have shown that the rs340874 single nucleotide polymorphism (SNP) in PROX1 is a genetic susceptibility factor for type 2 diabetes...
  2. Miettinen M, Wang Z. Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors. Am J Surg Pathol. 2012;36:351-9 pubmed publisher
    b>Prox1, a transcription factor important in the regulation and maintenance of the lymphatic endothelial phenotype, is consistently expressed in lymphangiomas and Kaposi sarcoma and has also been reported in Kaposiform hemangioendothelioma...
  3. Flister M, Wilber A, Hall K, Iwata C, Miyazono K, Nisato R, et al. Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. Blood. 2010;115:418-29 pubmed publisher
    ..The 2 primary mediators of lymphangiogenesis are vascular endothelial growth factor receptor-3 (VEGFR-3) and Prox1. The key factors that regulate inflammation-induced transcription are members of the nuclear factor-kappaB (NF-..
  4. Elsir T, Eriksson A, Orrego A, Lindström M, Nister M. Expression of PROX1 Is a common feature of high-grade malignant astrocytic gliomas. J Neuropathol Exp Neurol. 2010;69:129-38 pubmed publisher
    b>PROX1 is a prospero-related transcription factor that plays a critical role in the development of various organs including the mammalian lymphatic and central nervous systems; it controls cell proliferation and differentiation through ..
  5. Yoshimoto T, Takahashi M, Nagayama S, Watanabe G, Shimada Y, Sakasi Y, et al. RNA mutations of prox1 detected in human esophageal cancer cells by the shifted termination assay. Biochem Biophys Res Commun. 2007;359:258-62 pubmed
    We have recently reported a novel finding that a candidate tumor suppressor gene prox1 suffered adenosine-to-inosine (A-to-I) RNA mutation without genomic mutation in a subset of human cancer cells and lost its function...
  6. Qin J, Zhai J, Hong R, Shan S, Kong Y, Wen Y, et al. Prospero-related homeobox protein (Prox1) inhibits hepatitis B virus replication through repressing multiple cis regulatory elements. J Gen Virol. 2009;90:1246-55 pubmed publisher
    ..In this study, we report that nuclear factor Prospero-related homeobox protein (Prox1) represses HBV antigen expression and genome replication in cultured hepatocytes...
  7. Takahashi M, Yoshimoto T, Shimoda M, Kono T, Koizumi M, Yazumi S, et al. Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells. Neoplasia. 2006;8:1003-10 pubmed
    ..Here we report that the mRNA of a homeobox gene prox1, a candidate tumor suppressor, suffers adenosine-to-inosine nucleotide conversion and loses tumor-suppressive ..
  8. Pan M, Chang T, Chang H, Su J, Wang H, Hung W. Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells. J Cell Sci. 2009;122:3358-64 pubmed publisher
    b>Prox1 is a master regulator for the development of lymphatic vasculature and the induction of lymphangiogenesis. In this study, we identified Prox1 as a new target for small ubiquitin-like modifier 1 (SUMO-1)...
  9. Schneider M, Buchler P, Giese N, Giese T, Wilting J, Buchler M, et al. Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread. Int J Oncol. 2006;28:883-90 pubmed
    ..cell lines for mRNA expression of the lymphangiogenic growth factor, VEGF-C; its receptor, VEGFR-3/flt4; and Prox1, a transcription factor essential for embryonic development of both lymphatic vessels and the pancreatic bud...

More Information

Publications83

  1. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson A, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105-16 pubmed publisher
    ..nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1)...
  2. Zinovieva R, Duncan M, Johnson T, Torres R, Polymeropoulos M, Tomarev S. Structure and chromosomal localization of the human homeobox gene Prox 1. Genomics. 1996;35:517-22 pubmed
    ..The Prox 1 gene was mapped to human chromosome 1q32.2-q32.3. ..
  3. Nagai H, Li Y, Hatano S, Toshihito O, Yuge M, Ito E, et al. Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. Genes Chromosomes Cancer. 2003;38:13-21 pubmed
    The homeobox gene PROX1 is related to the Drosophila prospero gene, which is expressed in the developing central nervous system and lens-secreting cone cells...
  4. Risebro C, Petchey L, Smart N, Gomes J, Clark J, Vieira J, et al. Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Circ Res. 2012;111:e19-31 pubmed publisher
    ..5-dependent adult congenital heart disease. A study of cardiac function in prospero-related homeobox protein 1 (Prox1) heterozygous mice, using pressure-volume loop and micromannometry, revealed rescue of hemodynamic parameters in ..
  5. Elsir T, Smits A, Lindström M, Nister M. Transcription factor PROX1: its role in development and cancer. Cancer Metastasis Rev. 2012;31:793-805 pubmed publisher
    The homeobox gene PROX1 is critical for organ development during embryogenesis. The Drosophila homologue, known as prospero has been shown to act as a tumor suppressor by controlling asymmetric cell division of neuroblasts...
  6. Wigle J, Chowdhury K, Gruss P, Oliver G. Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999;21:318-22 pubmed
    ..The expression pattern of the Prox1 homeobox gene suggests it has a role in a variety of embryonic tissues, including lens...
  7. Shan S, Wang L, Zhai J, Qin Y, Ouyang H, Kong Y, et al. Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification. FEBS Lett. 2008;582:3723-8 pubmed publisher
    Prospero-related homeobox protein (Prox1) plays essential roles in the development of many tissues and organs. In the present study, we show that Prox1 is modified by the small ubiquitin-like protein SUMO-1 in cultured cells...
  8. Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, et al. Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. J Cell Sci. 2009;122:3923-30 pubmed publisher
    During lymphatic development, Prox1 plays central roles in the differentiation of blood vascular endothelial cells (BECs) into lymphatic endothelial cells (LECs), and subsequently in the maturation and maintenance of lymphatic vessels...
  9. Shimoda M, Takahashi M, Yoshimoto T, Kono T, Ikai I, Kubo H. A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. Clin Cancer Res. 2006;12:6005-11 pubmed
    It has been shown that a lymphatic differentiation master gene, prox1, also plays an essential role in fetal hepatocyte migration. Its expression is detected in embryonic hepatoblasts and in adult hepatocytes...
  10. Petrova T, Nykänen A, Norrmen C, Ivanov K, Andersson L, Haglund C, et al. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell. 2008;13:407-19 pubmed publisher
    ..factor Prospero functions as a tumor suppressor, and it has been suggested that the human counterpart of Prospero, PROX1, acts similarly in human cancers...
  11. Kang J, Yoo J, Lee S, Tang W, Aguilar B, Ramu S, et al. An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood. 2010;116:140-50 pubmed publisher
    ..Arteriovenous-lymphatic endothelial cell fates are specified by the master regulators, namely, Notch, COUP-TFII, and Prox1. Whereas Notch is expressed in the arteries and COUP-TFII in the veins, the lymphatics express all 3 cell fate ..
  12. Rodriguez Niedenführ M, Papoutsi M, Christ B, Nicolaides K, von Kaisenberg C, Tomarev S, et al. Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts. Anat Embryol (Berl). 2001;204:399-406 pubmed
    ..Recently it has been shown that mice deficient for the homeobox transcription factor Prox1 are practically devoid of lymphatics...
  13. Song K, Li T, Chiang J. A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. J Biol Chem. 2006;281:10081-8 pubmed
    b>Prox1, an early specific marker for developing liver and pancreas in foregut endoderm has recently been shown to interact with alpha-fetoprotein transcription factor and repress cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription...
  14. Dudas J, Papoutsi M, Hecht M, Elmaouhoub A, Saile B, Christ B, et al. The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium. Anat Embryol (Berl). 2004;208:359-66 pubmed
    b>Prox1 is a transcription factor with two highly conserved domains, a homeobox and a prospero domain. It has been shown that Prox1 knock-out mice die during early embryonic stages and display a rudimentary liver...
  15. Dyer M, Livesey F, Cepko C, Oliver G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet. 2003;34:53-8 pubmed
    ..We found that the homeodomain protein Prox1 regulates the exit of progenitor cells from the cell cycle in the embryonic mouse retina...
  16. Dadras S, Skrzypek A, Nguyen L, Shin J, Schulz M, Arbiser J, et al. Prox-1 promotes invasion of kaposiform hemangioendotheliomas. J Invest Dermatol. 2008;128:2798-806 pubmed publisher
    ..and vascular endothelial growth factor receptor-3, which is mediated by upregulation of the transcription factor Prox1. However, the potential effects of Prox1 expression on the biology of KS and, in particular, on the aggressive and ..
  17. Lee S, Kang J, Yoo J, Ganesan S, Cook S, Aguilar B, et al. Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood. 2009;113:1856-9 pubmed publisher
    ..Homeodomain transcription factor Prox1 functions to reprogram venous ECs to lymphatic endothelial cells (LECs)...
  18. Petrova T, Makinen T, Makela T, Saarela J, Virtanen I, Ferrell R, et al. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J. 2002;21:4593-9 pubmed
    ..Furthermore, the data provide insights into the phenotypic diversity of endothelial cells and into the possibility of transcriptional reprogramming of differentiated endothelial cells...
  19. Hong Y, Harvey N, Noh Y, Schacht V, Hirakawa S, Detmar M, et al. Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn. 2002;225:351-7 pubmed
    ..one of the first indications that lymphangiogenesis has begun is the polarized expression of the homeobox gene Prox1 in a subpopulation of venous endothelial cells...
  20. Skog M, Bono P, Lundin M, Lundin J, Louhimo J, Linder N, et al. Expression and prognostic value of transcription factor PROX1 in colorectal cancer. Br J Cancer. 2011;105:1346-51 pubmed publisher
    b>PROX1 is a specific target of the ?-catenin/TCF pathway in the intestinal epithelium. It acts as a regulator of progression from a benign to a highly dysplastic phenotype in colorectal tumours...
  21. Steffensen K, Holter E, Båvner A, Nilsson M, Pelto Huikko M, Tomarev S, et al. Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue. EMBO Rep. 2004;5:613-9 pubmed
    ..In this study, we have identified and characterized the homeodomain protein Prox1 as a co-repressor for liver receptor homologue 1 (LRH1/NR5A2), a master regulator of cholesterol homeostasis in ..
  22. Boesgaard T, Grarup N, Jørgensen T, Borch Johnsen K, Hansen T, Pedersen O. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. Diabetologia. 2010;53:1647-55 pubmed publisher
    ..Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the population-based Inter99 cohort...
  23. Ingelsson E, Langenberg C, Hivert M, Prokopenko I, Lyssenko V, Dupuis J, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes. 2010;59:1266-75 pubmed publisher
    ..in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity)...
  24. Qin J, Gao D, Jiang Q, Zhou Q, Kong Y, Wang Y, et al. Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. Mol Endocrinol. 2004;18:2424-39 pubmed
    ..In this report, we demonstrate Prox1, a prospero-related homeobox transcription factor, identified through a yeast two-hybrid screening, can directly ..
  25. Laerm A, Helmbold P, Goldberg M, Dammann R, Holzhausen H, Ballhausen W. Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system. J Hepatol. 2007;46:89-97 pubmed
    Functional deletion of the transcription factor Prospero-related homeobox 1 (PROX1) causes abnormal cellular proliferation via down-regulated expression of the cell cycle inhibitors p27(kip1) and p57(kip2)...
  26. Versmold B, Felsberg J, Mikeska T, Ehrentraut D, Köhler J, Hampl J, et al. Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer. Int J Cancer. 2007;121:547-54 pubmed
    ..we identified a hypermethylated CpG island within the first intron of the prospero related homeobox gene 1 (PROX1)...
  27. Miyoshi G, Young A, PETROS T, Karayannis T, McKenzie Chang M, Lavado A, et al. Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons. J Neurosci. 2015;35:12869-89 pubmed publisher
    ..Here, we report that in mice expression of the transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors and that loss of Prox1 ..
  28. Lu M, Huang C, Pan M, Chen H, Hung W. Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9. Clin Cancer Res. 2012;18:6416-25 pubmed publisher
    Prospero homeobox 1 (PROX1) has been shown to function as a tumor suppressor in various types of cancer. However, it promotes colon cancer progression...
  29. Zhang S, Yu N, Wang L, Liu Y, Kong Y, Liu J, et al. Prox1 represses IL-2 gene expression by interacting with NFAT2. Oncotarget. 2017;8:69422-69434 pubmed publisher
    ..Prospero-related homeobox 1 (Prox1) is a multifunctional transcription factor, which can work as either a transcriptional activator or repressor ..
  30. Bermudez Hernandez K, Lu Y, Moretto J, Jain S, Lafrancois J, Duffy A, et al. Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX. Brain Struct Funct. 2017;222:3147-3161 pubmed publisher
    ..Therefore, we used the transcription factor prospero homeobox 1 (Prox1) to quantify GCs at postnatal day (PND) 16, 30, and 60 in a common mouse strain, C57BL/6J mice...
  31. Yang Y, Shen W, Ni Y, Su Y, Yang Z, Zhao C. Impaired Interneuron Development after Foxg1 Disruption. Cereb Cortex. 2017;27:793-808 pubmed publisher
    ..Notably, Prox1, which is a transcription factor that functions as a key regulator in the development of excitatory neurons, was ..
  32. Zhao G, Bailey C, Feng Y, Rasko J, Lovicu F. Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred. Exp Eye Res. 2018;170:148-159 pubmed publisher
    ..suppress FGF-induced ERK1/2 phosphorylation in lens cells, as well as the ERK1/2-dependent fiber-specific marker Prox1, but not the accumulation of β-crystallins...
  33. Becker J, Wang B, Pavlakovic H, Buttler K, Wilting J. Homeobox transcription factor Prox1 in sympathetic ganglia of vertebrate embryos: correlation with human stage 4s neuroblastoma. Pediatr Res. 2010;68:112-7 pubmed publisher
    Previously, we observed expression of the homeobox transcription factor Prox1 in neuroectodermal embryonic tissues...
  34. Ghosheh N, Olsson B, Edsbagge J, Küppers Munther B, van Giezen M, Asplund A, et al. Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines. Stem Cells Int. 2016;2016:8648356 pubmed publisher
    ..RT-qPCR to assess the expression of lineage-specific genes (OCT4, NANOG, T, SOX17, CXCR4, CER1, HHEX, TBX3, PROX1, HNF6, AFP, HNF4a, KRT18, ALB, AAT, and CYP3A4) which serve as markers for different stages during liver ..
  35. Iida H, Ishii Y, Kondoh H. Intrinsic lens potential of neural retina inhibited by Notch signaling as the cause of lens transdifferentiation. Dev Biol. 2017;421:118-125 pubmed publisher
    ..After Notch signal inhibition, transcription factor genes that regulate the early stage of eye development, Prox1 and Pitx3, were sequentially activated...
  36. Jourdeuil K, Franz Odendaal T. Gene expression analysis during the induction and patterning of the conjunctival papillae in the chick embryonic eye. Gene Expr Patterns. 2016;22:30-36 pubmed publisher
    ..Furthermore, we identified two genes, ?-catenin and Prox1, that may be involved in the induction of the underlying scleral bones...
  37. Chen X, Tolkovsky A, Herbert J. Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat. PLoS ONE. 2011;6:e17072 pubmed publisher
    ..Only primary DG cells robustly generated DG neurons (80% NeuN and Prox1-positive cells at 6 weeks), substantially repaired the damaged DG, and formed glutamatergic projections to the ..
  38. Yu E, Kim S, Kim H, Heo K, Ou C, Stallcup M, et al. Positive regulation of β-catenin-PROX1 signaling axis by DBC1 in colon cancer progression. Oncogene. 2016;35:3410-8 pubmed publisher
    ..targets of DBC1 and found that loss of DBC1 inhibits the expression of β-catenin target genes including PROX1, a transcription factor linked to CRC progression...
  39. Schuster C, Mildner M, Botta A, Nemec L, Rogojanu R, Beer L, et al. Development of Blood and Lymphatic Endothelial Cells in Embryonic and Fetal Human Skin. Am J Pathol. 2015;185:2563-74 pubmed publisher
    ..Lymphatic progenitor cells at 8 weeks of estimated gestational age express CD31, CD144, Prox1, and temporary PAL-E...
  40. Hadj Hamou N, Lae M, Almeida A, de la Grange P, Kirova Y, Sastre Garau X, et al. A transcriptome signature of endothelial lymphatic cells coexists with the chronic oxidative stress signature in radiation-induced post-radiotherapy breast angiosarcomas. Carcinogenesis. 2012;33:1399-405 pubmed publisher
    ..In contrast, MYC amplification, which is observed in all radiation-induced tumors but also at a low rate in primary tumors, was not a marker of the radiation tumorigenesis. ..
  41. Gao T, Ma C, Li Y, Ju J, Kang X, Cai Y, et al. High Expression of Prospero-Related Homeobox-1 (PROX1) Is Associated With Poor Prognosis in Patients With Salivary Adenoid Cystic Carcinoma. J Oral Maxillofac Surg. 2018;76:1440-1446 pubmed publisher
    Prospero-related homeobox-1 (PROX1) plays an important role in the invasion and metastasis of many human cancers. However, the expression pattern of PROX1 in salivary adenoid cystic carcinoma (SACC) remains unclear...
  42. Panova I, Markitantova Y, Smirnova Y, Zinovieva R. [Molecular-genetic mechanisms of cornea morphogenesis]. Izv Akad Nauk Ser Biol. 2015;:117-26 pubmed
    ..data on the expression of regulatory genes encoding transcription factors Pax6/PAX6, Pitx2/PITX2, Fox1/FOXC1, Prox1/PROX1, Oct4/OCT4, Nanog/NANOG, and TGFβ2 signaling protein during morphogenesis of the cornea in vertebrates...
  43. Sun J, Rockowitz S, Xie Q, Ashery Padan R, Zheng D, Cvekl A. Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development. Nucleic Acids Res. 2015;43:6827-46 pubmed publisher
    ..In lens, Pax6 directly regulates cell cycle exit via components of FGF (Fgfr2, Prox1 and Ccnd1) and Wnt (Dkk3, Wnt7a, Lrp6, Bcl9l, and Ccnd1) signaling pathways...
  44. Park M, Kim J, Park I, Lee H, Kim C, Jo C, et al. Characterization of ticlopidine-induced developmental and teratogenic defects in Xenopus embryos and human endothelial cells. Chem Biol Interact. 2015;240:172-8 pubmed publisher
    ..severe hemorrhages and inhibited both blood and lymph vessel formation by modulating the expression of xMsr and Prox1 in Xenopus embryos. Additionally, Nkx2...
  45. Chang T, Hung W. Transcriptional repression of TWIST1 gene by Prospero-related homeobox 1 inhibits invasiveness of hepatocellular carcinoma cells. FEBS Lett. 2012;586:3746-52 pubmed publisher
    Prospero-related homeobox 1 (PROX1) is important for liver development and down-regulation of this transcription factor in hepatocellular carcinoma (HCC) is associated with poor prognosis...
  46. Aranguren X, Beerens M, Coppiello G, Wiese C, Vandersmissen I, Lo Nigro A, et al. COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1. J Cell Sci. 2013;126:1164-75 pubmed publisher
    ..whereby NR2F2 homodimers induce a venous EC fate, while heterodimers with the LEC-specific transcription factor PROX1 instruct LEC lineage specification...
  47. Geng X, Cha B, Mahamud M, Lim K, Silasi Mansat R, Uddin M, et al. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. 2016;409:218-233 pubmed publisher
    ..First, LVV-forming endothelial cells (LVV-ECs) differentiate from PROX1(+) progenitors and delaminate from the luminal side of the veins...
  48. Zhong W, Gao X, Wang S, Han K, Ema M, Adams S, et al. Prox1-GFP/Flt1-DsRed transgenic mice: an animal model for simultaneous live imaging of angiogenesis and lymphangiogenesis. Angiogenesis. 2017;20:581-598 pubmed publisher
    ..We bred transgenic mice in which lymphatic endothelial cells express GFP (Prox1-GFP) with mice in which vascular endothelial cells express DsRed (Flt1-DsRed) to generate Prox1-GFP/Flt1-DsRed (..
  49. Touzot A, Ruiz Reig N, Vitalis T, Studer M. Molecular control of two novel migratory paths for CGE-derived interneurons in the developing mouse brain. Development. 2016;143:1753-65 pubmed publisher
    ..appear in a precise temporal sequence and express a distinct combination of transcription factors, such as SP8, PROX1, COUP-TFI and COUP-TFII...
  50. Anand D, Lachke S. Systems biology of lens development: A paradigm for disease gene discovery in the eye. Exp Eye Res. 2017;156:22-33 pubmed publisher
    ..as Pax6, Six3, Sox2, Oct1 (Pou2f1), Meis1, Pnox1, Zeb2 (Sip1), Mab21l1, Foxe3, Tfap2a (Ap2-alpha), Pitx3, Sox11, Prox1, Sox1, c-Maf, Mafg, Mafk, Hsf4, Fgfrs, Bmp7, and Tdrd7 in this tissue...
  51. Nakamori D, Takayama K, Nagamoto Y, Mitani S, Sakurai F, Tachibana M, et al. Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction. Biochem Biophys Res Commun. 2016;469:424-9 pubmed publisher
    ..activating transcription factor 5 (ATF5), CCAAT/enhancer-binding protein alpha (c/EBPα), and prospero homeobox protein 1 (PROX1)) in adult liver were significantly higher than those in human iPS-HLCs and fetal liver, we ..
  52. Choi D, Ramu S, Park E, Jung E, Yang S, Jung W, et al. Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells. Cancer Res. 2016;76:582-93 pubmed publisher
    ..Here, we report that the regulator of cell fate specification, PROX1, becomes inactivated in PTC through mRNA downregulation and cytoplasmic mislocalization...
  53. Le Huu A, Jokinen C, Rubin B, Ruben B, Mihm M, Weiss S, et al. Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma. Am J Surg Pathol. 2010;34:1563-73 pubmed publisher
    ..Our recent results showed that ectopic overexpression of human Prox1 gene, a lymphatic endothelial nuclear transcription factor, promoted an aggressive behavior in 2 murine models of ..
  54. Liu Y, Ye X, Zhang J, Ouyang H, Shen Z, Wu Y, et al. PROX1 promotes hepatocellular carcinoma proliferation and sorafenib resistance by enhancing β-catenin expression and nuclear translocation. Oncogene. 2015;34:5524-35 pubmed publisher
    ..The mechanism for the latter remains poorly understood. Prospero-related homeobox 1 (PROX1) is a downstream target of the Wnt/β-catenin pathway in human colorectal cancer and elevated PROX1 expression ..
  55. McGovern M, Brancheck J, Grant A, Graves K, Cox B. Quantitative Analysis of Supporting Cell Subtype Labeling Among CreER Lines in the Neonatal Mouse Cochlea. J Assoc Res Otolaryngol. 2017;18:227-245 pubmed publisher
    ..Changes to the tamoxifen dose or reporter line with Prox1 CreERT2 caused minimal changes...
  56. Deng J, Dai T, Sun Y, Zhang Q, Jiang Z, Li S, et al. Overexpression of Prox1 Induces the Differentiation of Human Adipose-Derived Stem Cells into Lymphatic Endothelial-Like Cells In Vitro. Cell Reprogram. 2017;19:54-63 pubmed publisher
    Constant levels of homeobox transcription factor Prox1 expression are required throughout the life of lymphatic endothelial cells (LECs) to maintain their differentiated identity...
  57. Pan Y, Wang W, Yago T. Transcriptional regulation of podoplanin expression by Prox1 in lymphatic endothelial cells. Microvasc Res. 2014;94:96-102 pubmed publisher
    ..develop abnormal and blood-filled lymphatic vessels that highly resemble those in inducible mice lacking Prox-1 (Prox1(-/-)). Prox1 has also been reported to induce PDPN expression in cultured ECs...
  58. Hodonsky C, Jain D, Schick U, Morrison J, Brown L, McHugh C, et al. Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. PLoS Genet. 2017;13:e1006760 pubmed publisher
    ..significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 rs941718), and hematocrit (PROX1 rs3754140)...
  59. Liu Y, Zhang Y, Wang S, Dong Q, Shen Z, Wang W, et al. Prospero-related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating interleukin-8 expression. Hepatology. 2017;66:1894-1909 pubmed publisher
    ..In this study, Prospero-related homeobox 1 (PROX1) was identified as a novel proangiogenic factor in HCC cell lines and tissues...
  60. Marouli E, Kanoni S, Mamakou V, Hackinger S, Southam L, Prins B, et al. Evaluating the glucose raising effect of established loci via a genetic risk score. PLoS ONE. 2017;12:e0186669 pubmed publisher
    ..019 ± 0.003, P = 1.41e-09. Also, variants at the SLC30A8, PROX1, MTNR1B, ADRA2A, G6PC2, LPIN3 loci indicated nominal evidence for association with glucose levels (p < 0.05)...
  61. Fujita H, Hara K, Shojima N, Horikoshi M, Iwata M, Hirota Y, et al. Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits. J Hum Genet. 2012;57:776-9 pubmed publisher
    ..We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (..
  62. Hagiwara K, Ito H, Murate T, Miyata Y, Ohashi H, Nagai H. PROX1 overexpression inhibits protein kinase C beta II transcription through promoter DNA methylation. Genes Chromosomes Cancer. 2012;51:1024-36 pubmed publisher
    Prospero-related homeobox 1 (PROX1) is important for embryonic organ formation and differentiation, and changes in PROX1 activity were recently associated with cancer...
  63. Hunt N, Hallam D, Karimi A, Mellough C, Chen J, Steel D, et al. 3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development. Acta Biomater. 2017;49:329-343 pubmed publisher
    ..5% RGD-alginate hydrogel encapsulation did not adversely affect the expression of other neural retina markers (PROX1, CRX, RCVRN, AP2α or VSX2) as determined by qRT-PCR, or the percentage of VSX2 positive cells as determined by ..
  64. Zhou B, Si W, Su Z, Deng W, Tu X, Wang Q. Transcriptional activation of the Prox1 gene by HIF-1? and HIF-2? in response to hypoxia. FEBS Lett. 2013;587:724-31 pubmed publisher
    b>Prox1 encodes a homeobox transcription factor critical to organ development, but its regulation is poorly understood...
  65. Cimpean A, Poenaru Sava M, Raica M, Ribatti D. Preliminary evidence of the presence of lymphatic vessels immunoreactive for D2-40 and Prox-1 in human pterygium. Oncol Rep. 2011;26:1111-3 pubmed publisher
    ..Overall, these data clearly indicate the presence of active proliferating lymphatic vessels in human pterygium, suggesting that active lymphangiogenesis occurs in this pathological condition...
  66. Zhu S, Shan C, Wu Z, Xu S. Proliferation of small cell lung cancer cell line reduced by knocking-down PROX1 via shRNA in lentivirus. Anticancer Res. 2013;33:3169-75 pubmed
    The present study aimed to find whether PROX1 is expressed in small cell lung cancer (SCLC) cell lines, and whether PROX1 knockdown with shRNA via lentivirus resulted in decreased cell proliferation...
  67. Sasahira T, Ueda N, Yamamoto K, Kurihara M, Matsushima S, Bhawal U, et al. Prox1 and FOXC2 act as regulators of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma. PLoS ONE. 2014;9:e92534 pubmed publisher
    Prospero homeobox 1 (Prox1) and forkhead box (FOX) C2 regulate angiogenesis and/or lymphangiogenesis. However, the detailed role and function of Prox1 and FOXC2 in cancer remains controversial...
  68. Hu C, Zhang R, Wang C, Wang J, Ma X, Hou X, et al. Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese. PLoS ONE. 2010;5:e15542 pubmed publisher
    ..SNPs) from fifteen loci including GIPR, ADCY5, TCF7L2, VPS13C, DGKB, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B, SLC30A8 and IGF1 in 6,822 Shanghai Chinese Hans comprising 3,410 type 2 diabetic patients and 3,412 ..
  69. Wang B, Huang J, Zhou J, Hui K, Xu S, Fan J, et al. DAB2IP regulates EMT and metastasis of prostate cancer through targeting PROX1 transcription and destabilizing HIF1? protein. Cell Signal. 2016;28:1623-30 pubmed publisher
    Prospero-related homeobox 1 (PROX1) is an essential regulator in lymphangiogenesis and has been implicated in both oncogenic and tumor-suppressive functions in many types of human cancers...
  70. He S, Limi S, McGreal R, Xie Q, Brennan L, Kantorow W, et al. Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development. 2016;143:1937-47 pubmed publisher
    ..forming the lens vesicle, implicating Snf2h as a key regulator of lens vesicle polarity through spatial control of Prox1, Jag1, p27(Kip1) (Cdkn1b) and p57(Kip2) (Cdkn1c) gene expression...
  71. Wang D, Wang E, Liu K, Xia C, Li S, Gong X. Roles of TGFβ and FGF signals during growth and differentiation of mouse lens epithelial cell in vitro. Sci Rep. 2017;7:7274 pubmed publisher
    ..promoted mouse LEC proliferation, maintained LECs' morphology and distinct markers including N-cadherin, c-Maf, Prox1, and αA-, αB-, and β-crystallins...
  72. Armour S, Remsberg J, Damle M, Sidoli S, Ho W, Li Z, et al. An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides. Nat Commun. 2017;8:549 pubmed publisher
    ..interactome in vivo that includes the canonical NCoR-HDAC3 complex as well as Prospero-related homeobox 1 protein (PROX1)...
  73. Kim J, Park D, Bae H, Park D, Kim D, Lee C, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877-3896 pubmed publisher
    ..that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling, AHO, and Prox1 activity. These functions diminish in the SC during aging, leading to impaired integrity and transcytosis...
  74. Rodrigues M, de Oliveira Rodini C, de Aquino Xavier F, Paiva K, Severino P, Moyses R, et al. PROX1 gene is differentially expressed in oral cancer and reduces cellular proliferation. Medicine (Baltimore). 2014;93:e192 pubmed publisher
    ..Homeobox genes are a family of transcription factors that play a pivotal role in embryogenesis. Prospero homeobox 1 (PROX1) has been shown to function as a tumor suppressor gene or oncogene in various types of cancer, including oral ..