protein tyrosine phosphatase epsilon


Gene Symbol: protein tyrosine phosphatase epsilon
Description: protein tyrosine phosphatase, receptor type E
Alias: HPTPE, PTPE, R-PTP-EPSILON, receptor-type tyrosine-protein phosphatase epsilon, protein tyrosine phosphatase, receptor type, epsilon polypeptide
Species: human

Top Publications

  1. Tiran Z, Peretz A, Attali B, Elson A. Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. J Biol Chem. 2003;278:17509-14 pubmed
    ..Together, these results indicate that Tyr(124) is a significant site at which the mutually antagonistic activities of Src and cyt-PTPepsilon affect Kv2.1 phosphorylation and activity. ..
  2. Toledano Katchalski H, Tiran Z, Sines T, Shani G, Granot Attas S, den Hertog J, et al. Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Mol Cell Biol. 2003;23:5460-71 pubmed
    ..Furthermore, dimerization can be mediated by the D2 domain and does not strictly require the presence of PTP extracellular domains. ..
  3. Wabakken T, Hauge H, Finne E, Wiedlocha A, Aasheim H. Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase. Scand J Immunol. 2002;56:195-203 pubmed
    The expression of protein tyrosine phosphatase epsilon (PTPepsilon) was studied in human tissues and blood cells...
  4. Shalev M, Elson A. The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts. Biochim Biophys Acta. 2018;: pubmed publisher
    ..PTPs of the classical and dual-specificity sub-families that are known to support these processes (SHP2, cyt-PTPe, PTPRO, PTP-PEST, CD45) or to inhibit them (SHP1, PTEN, MKP1)...
  5. Kubo N, Harimoto N, Shibuya K, Ishii N, Tsukagoshi M, Igarashi T, et al. Successful treatment of isolated bile leakage after hepatectomy combination therapy with percutaneous transhepatic portal embolization and bile duct ablation with ethanol: a case report. Surg Case Rep. 2018;4:61 pubmed publisher
    ..duct leakage managed successfully by combination therapy of percutaneous transhepatic portal vein embolization (PTPE) and bile duct ablation with ethanol...
  6. Granot Attas S, Luxenburg C, Finkelshtein E, Elson A. Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src. Mol Biol Cell. 2009;20:4324-34 pubmed publisher
    The nonreceptor isoform of tyrosine phosphatase epsilon (cyt-PTPe) supports osteoclast adhesion and activity in vivo, leading to increased bone mass in female mice lacking PTPe (EKO mice)...
  7. Levy Apter E, Finkelshtein E, Vemulapalli V, Li S, Bedford M, Elson A. Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts. J Biol Chem. 2014;289:36048-58 pubmed publisher
    The non-receptor isoform of protein-tyrosine phosphatase ϵ (cyt-PTPe) supports adhesion of bone-resorbing osteoclasts by activating Src downstream of integrins...
  8. Kober P, Boresowicz J, Rusetska N, Maksymowicz M, Goryca K, Kunicki J, et al. DNA methylation profiling in nonfunctioning pituitary adenomas. Mol Cell Endocrinol. 2018;473:194-204 pubmed publisher
    ..Nevertheless, invasiveness-related aberrant epigenetic deregulation of the particular genes was found including upregulation of ITPKB and downregulation CNKSR1 in invasive tumors. ..
  9. Bhattarai N, McLinden J, Xiang J, Kaufman T, Stapleton J. Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation. PLoS Pathog. 2015;11:e1005183 pubmed publisher
    ..These effects of HCV particles likely aid in establishing infection and contribute to viral persistence. ..

More Information


  1. Chen W, Wang C, Hung Y, Weng T, Yen M, Lai M. Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer. PLoS ONE. 2016;11:e0155660 pubmed publisher
    ..Altogether, different members of ACSLs are implicated in diverse types of cancer development. ACSL-coexpressed molecules may be used to further investigate the role of ACSL family in individual type of cancers. ..
  2. Okumura Y, Kohashi K, Wang H, Kato M, Maehara Y, Ogawa Y, et al. Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report. Pathol Res Pract. 2017;213:1322-1326 pubmed publisher
    ..with transcatheter arterial chemoembolization (TACE) and percutaneous transhepatic portal vein embolization (PTPE) therapy five weeks before the operation...
  3. Sohda T, Iwata K, Anan A, Kunimoto H, Yotsumoto K, Yokoyama K, et al. Upregulation of des-gamma-carboxy-prothrombin after portal vein embolization in a cirrhotic patient with hepatocellular carcinoma. Clin J Gastroenterol. 2015;8:330-4 pubmed publisher
    ..A 73-year-old female with hepatocellular carcinoma (HCC) received percutaneous transhepatic portal vein embolization (PTPE) before extensive right lobe hepatectomy...
  4. Inoue S, Ikeda O, Nakasone Y, Beppu T, Masuda T, Yokoyama K, et al. Percutaneous transhepatic portal embolization using foam ethanolamine oleate and carbon dioxide (COâ‚‚): a pilot study. Acta Radiol. 2015;56:1361-7 pubmed publisher
    Percutaneous transhepatic portal embolization (PTPE) can induce atrophy of the embolized- and hypertrophy of the residual area. These effects are advantageous in patients scheduled for extended hepatectomy...
  5. Elson A, Kozak C, Morton C, Weremowicz S, Leder P. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics. 1996;31:373-5 pubmed
    We have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses...
  6. Vaughan L, Wiener H, Aslibekyan S, Allison D, Havel P, Stanhope K, et al. Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population. Metabolism. 2015;64:689-97 pubmed publisher
    ..0004). This study presents evidence of novel genomic regions and gene-diet interactions that may contribute to the pathophysiology of obesity-related traits among Yup'ik people. ..
  7. Muja N, Lovas G, Romm E, Machleder D, Ranjan M, Gallo V, et al. Expression of a catalytically inactive transmembrane protein tyrosine phosphatase epsilon (tm-PTP epsilon) delays optic nerve myelination. Glia. 2004;48:278-97 pubmed
    ..To interfere with the subset of the phosphorylation cycle overseen by protein tyrosine phosphatase epsilon (PTP epsilon) in oligodendrocytes, we applied a substrate-trapping approach in the development of ..
  8. Murk W, Walsh K, Hsu L, Zhao L, Bracken M, Dewan A. Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma. Hum Hered. 2011;71:97-105 pubmed publisher
    ..Lack of evidence of highly reported polymorphisms in the present study highlights the genetic heterogeneity of asthma and emphasizes the need for robust replication of candidate genes. ..
  9. Elson A, Leder P. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. Proc Natl Acad Sci U S A. 1995;92:12235-9 pubmed
    ..PTP epsilon-cytoplasmic is therefore the initial example to our knowledge of a nontransmembranal protein-tyrosine phosphatase that contains two tandem of catalytic domains. ..
  10. Tremblay K, Lemire M, Potvin C, Tremblay A, Hunninghake G, Raby B, et al. Genes to diseases (G2D) computational method to identify asthma candidate genes. PLoS ONE. 2008;3:e2907 pubmed publisher
    ..These results demonstrate that the G2D tool can be useful in the selection of candidate genes located in chromosomal regions linked to a complex trait. ..
  11. Nakagawa Y, Yamada N, Shimizu H, Shiota M, Tamura M, Kim Mitsuyama S, et al. Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src. Biochem Biophys Res Commun. 2004;325:314-9 pubmed
    ..Considering the behaviors of vascular ECs in the pathogenesis of atherosclerosis, these data suggest that PTPepsilonM negatively regulates the development of this disease by activating c-Src. ..
  12. Iwao Y, Ojima H, Kobayashi T, Kishi Y, Nara S, Esaki M, et al. Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis. World J Hepatol. 2017;9:1227-1238 pubmed publisher
    To clarify the histological changes associated with liver atrophy after percutaneous transhepatic portal embolization (PTPE) in pigs and humans.
  13. McLinden J, Bhattarai N, Stapleton J, Chang Q, Kaufman T, CASSEL S, et al. Yellow fever virus, but not Zika or Dengue virus inhibits T cell receptor-mediated T cell function by an RNA-based mechanism. J Infect Dis. 2017;: pubmed publisher
    ..Together, these data suggest that viruses within the flavivirus genus inhibit TCR signaling in a species-dependent manner...
  14. Benjamin E, Dupuis J, Larson M, Lunetta K, Booth S, Govindaraju D, et al. Genome-wide association with select biomarker traits in the Framingham Heart Study. BMC Med Genet. 2007;8 Suppl 1:S11 pubmed
    ..cgi?id=phs000007 webcite. The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability. The newly described associations will need to be replicated in other studies. ..
  15. Wu D, Li Y, Yang J, Shen J, Zhou J, Hu Q, et al. Supramolecular Nanomedicine Constructed from Curcurbit[8]uril-Based Amphiphilic Brush Copolymer for Cancer Therapy. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    An amphiphilic supramolecular brush copolymer CB[8]?(PEG-Np·PTPE) was constructed on the basis of a novel host-guest molecular recognition model formed by cucurbit[8]uril (CB[8]), 4,4'-bipyridinium derivative (PQ) and PEGylated naphthol (..
  16. Wabakken T, Hauge H, Funderud S, Aasheim H. Characterization, expression and functional aspects of a novel protein tyrosine phosphatase epsilon isoform. Scand J Immunol. 2002;56:276-85 pubmed
    ..This report describes the identification and characterization of a novel cytoplasmic isoform of human protein tyrosine phosphatase epsilon (PTPepsilon)...
  17. Murakawa K, Matsubara K, Fukushima A, Yoshii J, Okubo K. Chromosomal assignments of 3'-directed partial cDNA sequences representing novel genes expressed in granulocytoid cells. Genomics. 1994;23:379-89 pubmed
    ..A highly sensitive laser fluorescent analyzer and ethidium staining were used for simple and large-scale PCR mapping. ..
  18. Toledano Katchalski H, Elson A. The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2. Oncogene. 1999;18:5024-31 pubmed
    The protein tyrosine phosphatase Epsilon (PTPepsilon) gene gives rise to two physiologically-distinct protein products - a transmembranal, receptor-like form and a cytoplasmic, non-receptor form...
  19. Tanuma N, Nakamura K, Shima H, Kikuchi K. Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells. J Biol Chem. 2000;275:28216-21 pubmed
    ..These results suggest an important role for PTPepsilonC in negative regulation of IL-6- and LIF-induced Jak-STAT signaling. ..
  20. Kraut Cohen J, Muller W, Elson A. Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling. J Biol Chem. 2008;283:4612-21 pubmed
    ..In so doing, Neu contributes to the coherence of the promitogenic role of PTPepsilon in this system. ..
  21. Kabir N, Ronnstrand L, Kazi J. Deregulation of protein phosphatase expression in acute myeloid leukemia. Med Oncol. 2013;30:517 pubmed publisher
    ..Our results provide an overview of protein phosphatase deregulation in AML. ..
  22. Okubo K, Itoh K, Fukushima A, Yoshii J, Matsubara K. Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles. Genomics. 1995;30:178-86 pubmed
  23. van den Maagdenberg A, van den Hurk H, Weghuis D, Wieringa B, Geurts van Kessel A, Hendriks W. Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization. Genomics. 1995;30:128-9 pubmed
  24. Roskoski R. Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun. 2005;331:1-14 pubmed
  25. Bhattarai N, McLinden J, Xiang J, Mathahs M, Schmidt W, Kaufman T, et al. Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo. PLoS Pathog. 2017;13:e1006232 pubmed publisher
    ..Together, these data demonstrate that HCV infection reduces PTPRE expression in the liver and PBMCs of infected humans, and suggest that the HCV E2 vsRNA is a novel viral factor that may contribute towards viral persistence. ..
  26. Gil Henn H, Volohonsky G, Toledano Katchalski H, Gandre S, Elson A. Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. Oncogene. 2000;19:4375-84 pubmed
  27. Nakagawa Y, Aoki N, Aoyama K, Shimizu H, Shimano H, Yamada N, et al. Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver. Zoolog Sci. 2005;22:169-75 pubmed
    ..These results suggest that PTPepsilonM is a negative regulator of IR signaling and involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. ..
  28. Toledano Katchalski H, Kraut J, Sines T, Granot Attas S, Shohat G, Gil Henn H, et al. Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases. Mol Cancer Res. 2003;1:541-50 pubmed
    ..We show that protein tyrosine phosphatase epsilon (PTP epsilon) inhibits ERK1 and ERK2 kinase activity and reduces their phosphorylation; in ..
  29. Blanchetot C, Tertoolen L, Overvoorde J, den Hertog J. Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. J Biol Chem. 2002;277:47263-9 pubmed
    ..The RPTP-D2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs. ..
  30. Peretz A, Gil Henn H, Sobko A, Shinder V, Attali B, Elson A. Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J. 2000;19:4036-45 pubmed
    b>Protein tyrosine phosphatase epsilon (PTP epsilon) is strongly expressed in the nervous system; however, little is known about its physiological role...
  31. Codreanu S, Hoeksema M, Slebos R, Zimmerman L, Rahman S, Li M, et al. Identification of Proteomic Features To Distinguish Benign Pulmonary Nodules from Lung Adenocarcinoma. J Proteome Res. 2017;16:3266-3276 pubmed publisher
    ..These studies illustrate the value of global and targeted proteomics in a systematic process to identify and qualify candidate biomarkers for noninvasive molecular diagnosis of lung cancer. ..
  32. Rato S, Maia S, Brito P, Resende L, Pereira C, Moita C, et al. Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells. PLoS ONE. 2010;5:e9276 pubmed publisher
    ..This study brings new insights for the complex interplay of HIV-1/host cell and opens new possibilities for antiviral strategies. ..
  33. Gastier J, Brody T, Pulido J, Businga T, Sunden S, Hu X, et al. Development of a screening set for new (CAG/CTG)n dynamic mutations. Genomics. 1996;32:75-85 pubmed
    ..The 141 STSs that were developed based on (CAG/CTG)n repeats of at least seven units were genotyped on four reference CEPH individuals to estimate their polymorphic quality. ..
  34. Granot Attas S, Elson A. Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells. Exp Cell Res. 2004;294:236-43 pubmed
    The receptor-type form of protein tyrosine phosphatase epsilon (RPTP) is among the few tyrosine phosphatases that can support the transformed phenotype of tumor cells...
  35. Nunes Xavier C, Elson A, Pulido R. Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells. J Biol Chem. 2012;287:3433-44 pubmed publisher
  36. Krueger N, Streuli M, Saito H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 1990;9:3241-52 pubmed
    ..The PTPase-like domains of HPTP alpha, beta and delta expressed in Escherichia coli had tyrosine phosphatase activities. ..