protein C inhibitor

Summary

Gene Symbol: protein C inhibitor
Description: serpin family A member 5
Alias: PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI, plasma serine protease inhibitor, acrosomal serine protease inhibitor, plasminogen activator inhibitor III, plasminogen activator inhibitor-3, protein C inhibitor, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Species: human
Products:     protein C inhibitor

Top Publications

  1. Espana F, Gilabert J, Estelles A, Romeu A, Aznar J, Cabo A. Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. Thromb Res. 1991;64:309-20 pubmed
    b>Protein C inhibitor (PCI) is a heparin-dependent serpin present in a native form in plasma at concentrations of 5 micrograms/mL...
  2. Christensson A, Lilja H. Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen. Eur J Biochem. 1994;220:45-53 pubmed
    b>Protein C inhibitor (PCI), a serine-proteinase inhibitor first purified from human blood plasma, occurs at high concentrations (3-4 microM) in seminal fluid in both a high-molecular-mass and low-molecular-mass form...
  3. Radtke K, Fernandez J, Greengard J, Tang W, Wilson C, Loskutoff D, et al. Protein C inhibitor is expressed in tubular cells of human kidney. J Clin Invest. 1994;94:2117-24 pubmed
    b>Protein C inhibitor (PCI) is a serpin that inhibits a number of proteases. PCI is found in urine and binds to kidney epithelial cells. To determine if kidney is a source of PCI, cDNA was produced from human kidney total RNA...
  4. Elisen M, von dem Borne P, Bouma B, Meijers J. Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma. Blood. 1998;91:1542-7 pubmed
    b>Protein C inhibitor (PCI), which was originally identified as an inhibitor of activated protein C, also efficiently inhibits coagulation factors such as factor Xa and thrombin...
  5. He S, Lin Y, Liu Y. Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility. Mol Hum Reprod. 1999;5:513-9 pubmed
    b>Protein C inhibitor (PCI) has been found in seminal plasma and is considered to protect intact surrounding cells and seminal plasma proteins from possible proteolytic damage...
  6. Borgmann S, Endisch G, Urban S, Sitter T, Fricke H. A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis. Clin Immunol. 2001;98:244-8 pubmed
    ..gene is part of a cluster of serine protease inhibitor (serpin) genes (AACT; alpha1-antichymotrypsin, PCI; protein C inhibitor, CBG; corticosteroid binding globulin, PIL; PI-like pseudogene) at chromosome 14q32.1...
  7. Izutani W, Fujita M, Nishizawa K, Koga J. The trimannosyl cores of N-glycans are important for the procoagulant protease-inhibitory activity of urinary protein C inhibitor. Thromb Res. 2001;104:65-74 pubmed
    ..relationship between the procoagulant protease-inhibitory activity and the N-glycan structures in urinary protein C inhibitor (uPCI) by sequential exoglycosidase digestions based on the N-glycan structures elucidated in this report...
  8. Sun W, Parry S, Ubhayasekera W, Engström Å, Dell A, Schedin Weiss S. Further insight into the roles of the glycans attached to human blood protein C inhibitor. Biochem Biophys Res Commun. 2010;403:198-202 pubmed publisher
    b>Protein C inhibitor (PCI) is a 57-kDa glycoprotein that exists in many tissues and secretions in human. As a member of the serpin superfamily of proteins it displays unusually broad protease specificity...
  9. Laurell M, Christensson A, Abrahamsson P, Stenflo J, Lilja H. Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system. J Clin Invest. 1992;89:1094-101 pubmed
    An assay was developed for the measurement of human protein C inhibitor antigen (PCI) in blood plasma and other biological fluids...

More Information

Publications118 found, 100 shown here

  1. Suzuki K, Nishioka J, Kusumoto H, Hashimoto S. Mechanism of inhibition of activated protein C by protein C inhibitor. J Biochem. 1984;95:187-95 pubmed
    b>Protein C inhibitor isolated from human plasma inhibited thrombin, factor Xa, trypsin and chymotrypsin as well as activated protein C, but had very little effect on urokinase and plasmin...
  2. Moore A, Penfold L, Johnson J, Latchman D, Moore H. Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor. Mol Reprod Dev. 1993;34:280-91 pubmed
    ..that cDNA 134 coded for a portion of a serine protease inhibitor (serpin) closely related to plasma Protein C inhibitor. Sequencing of an additional cDNA clone (261) and Northern blot analysis confirmed that a Protein C ..
  3. Espana F, Fink E, Sánchez Cuenca J, Gilabert J, Estelles A, Witzgall K. Complexes of tissue kallikrein with protein C inhibitor in human semen and urine. Eur J Biochem. 1995;234:641-9 pubmed
    An ELISA was developed for quantifying the complex between tissue kallikrein (tKK) and protein C inhibitor (PCI) (tKK:PCI) in seminal plasma and urine...
  4. Prendes M, Bielek E, Zechmeister Machhart M, Vanyek Zavadil E, Carroll V, Breuss J, et al. Synthesis and ultrastructural localization of protein C inhibitor in human platelets and megakaryocytes. Blood. 1999;94:1300-12 pubmed
    The occurrence of protein C inhibitor (PCI) in human platelets and megakaryocytes was analyzed. As judged from enzyme-linked immunosorbent assays (ELISAs), PCI was present in platelets at a concentration of 160 ng/2 x 10(9) cells...
  5. Uhrin P, Dewerchin M, Hilpert M, Chrenek P, Schöfer C, Zechmeister Machhart M, et al. Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest. 2000;106:1531-9 pubmed
    b>Protein C inhibitor (PCI) is a nonspecific, heparin-binding serpin (serine protease inhibitor) that inactivates many plasmatic and extravascular serine proteases by forming stable 1:1 complexes...
  6. Bungum M, Giwercman A, Bungum L, Humaidan P, Rastkhani H, Giwercman Y. Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure. Fertil Steril. 2010;93:277-9 pubmed publisher
    ..fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened ..
  7. Malmström E, Morgelin M, Malmsten M, Johansson L, Norrby Teglund A, Shannon O, et al. Protein C inhibitor--a novel antimicrobial agent. PLoS Pathog. 2009;5:e1000698 pubmed publisher
    b>Protein C inhibitor (PCI) is a heparin-binding serine proteinase inhibitor belonging to the family of serpin proteins. Here we describe that PCI exerts broad antimicrobial activity against bacterial pathogens...
  8. Bijsmans I, Smits K, de Graeff P, Wisman G, van der Zee A, Slangen B, et al. Loss of SerpinA5 protein expression is associated with advanced-stage serous ovarian tumors. Mod Pathol. 2011;24:463-70 pubmed publisher
  9. Fujita M, Izutani W, Takahashi K, Nishizawa K, Shirono H, Koga J. Role of each Asn-linked glycan in the anticoagulant activity of human protein C inhibitor. Thromb Res. 2002;105:95-102 pubmed
    The N-glycosylation site mutants of human protein C inhibitor (PCI; N230S, N243Q, N319Q, N230S/N243Q, and N230S/N319Q) were prepared by amino acid replacement of the asparagine residue with a serine or glutamine residue using site-..
  10. Yang H, Wahlmüller F, Sarg B, Furtmüller M, Geiger M. A+-helix of protein C inhibitor (PCI) is a cell-penetrating peptide that mediates cell membrane permeation of PCI. J Biol Chem. 2015;290:3081-91 pubmed publisher
    b>Protein C inhibitor (PCI) is a serpin with broad protease reactivity. It binds glycosaminoglycans and certain phospholipids that can modulate its inhibitory activity...
  11. Martin E, Buzza M, Driesbaugh K, Liu S, Fortenberry Y, Leppla S, et al. Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden. Oncotarget. 2015;6:33534-53 pubmed publisher
    ..PrAg's native activation sequence was mutated to a sequence derived from protein C inhibitor (PCI) that can be cleaved by membrane-anchored serine proteases, to generate the mutant protein PrAg-PCIS...
  12. Wahlmüller F, Yang H, Furtmüller M, Geiger M. Regulation of the Extracellular SERPINA5 (Protein C Inhibitor) Penetration Through Cellular Membranes. Adv Exp Med Biol. 2017;966:93-101 pubmed publisher
    ..SERPINA5 (protein C inhibitor) is a secreted protease inhibitor with broad protease reactivity and wide tissue distribution...
  13. Huntington J. Thrombin inhibition by the serpins. J Thromb Haemost. 2013;11 Suppl 1:254-64 pubmed publisher
    ..Although antithrombin (AT), protein C inhibitor (PCI), heparin cofactor II (HCII) and protease nexin-1 (PN1) all share a common fold and mechanism of ..
  14. Jendrny C, Beck Sickinger A. Inhibition of Kallikrein-Related Peptidases 7 and 5 by Grafting Serpin Reactive-Center Loop Sequences onto Sunflower Trypsin Inhibitor-1 (SFTI-1). Chembiochem. 2016;17:719-26 pubmed publisher
    ..Peptides based on kallistatin, α1 -antichymotrypsin, and protein C inhibitor (PCI) inhibited KLK7 with Ki =0.4, 0.5, and 0.7 μm, respectively...
  15. Lang I, Badr Eslam R, Greenlaw N, Young R, Steg P. Management and clinical outcome of stable coronary artery disease in Austria : Results from 5 years of the CLARIFY registry. Wien Klin Wochenschr. 2017;129:879-892 pubmed publisher
    ..registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization (CABG or PCI), coronary stenosis of more than 50% by coronary angiography or chest pain with myocardial ischemia...
  16. Tsai I, Wang C, Lu Y, Hung W, Wu C, Lu L, et al. The burden of major adverse cardiac events in patients with coronary artery disease. BMC Cardiovasc Disord. 2017;17:1 pubmed publisher
    ..disease (CAD) (654 with acute coronary syndrome (ACS) and 866 with elective percutaneous coronary intervention (PCI) patients) who received PCI and/or stenting...
  17. Awan M, Omar B, Qureshi G, Awan G. Successful Treatment of Iatrogenic External Iliac Artery Perforation With Covered Stent: Case Report and Review of the Literature. Cardiol Res. 2017;8:246-253 pubmed publisher
    ..artery bypass surgery; therefore, the decision was made to perform high-risk percutaneous coronary intervention (PCI) of the LAD with Impella left ventricular assist device support...
  18. Wang K, Chen L, Liu L, Cui Y, Zhang X, Jiang J. The effects of atorvastatin on IL-6, CRP, blood lipid and myocardial protection of interventional therapy in patients with acute myocardial infarction. Minerva Med. 2018;: pubmed publisher
    ..with intensive atorvastatin based on conventional therapy before and after percutaneous coronary intervention (PCI), while those in control group were treated with conventional therapy before and after PCI...
  19. Kakou Guikahue M, N guetta R, Anzouan Kacou J, Kramoh E, N Dori R, Ba S, et al. Optimizing the management of acute coronary syndromes in sub-Saharan Africa: A statement from the AFRICARDIO 2015 Consensus Team. Arch Cardiovasc Dis. 2016;109:376-83 pubmed publisher
    ..of patients eligible for myocardial reperfusion (thrombolytic therapy and/or percutaneous coronary intervention [PCI]). With only five catheterization laboratories in the 10 participating countries, PCI rates are very low...
  20. Suo X, Yang S, Ma Z, Sun T, Zhang W, Cong H, et al. [Effect of probucol on preventing contrast-induced nephropathy in patients undergoing percutaneous coronary intervention]. Zhonghua Yi Xue Za Zhi. 2017;97:3234-3238 pubmed publisher
    ..mechanism and safety of probucol on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD)...
  21. Helseth R, Weiss T, Opstad T, Siegbahn A, Solheim S, Freynhofer M, et al. Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction. Thromb Res. 2015;136:1240-4 pubmed publisher
    ..In 33 AMI patients undergoing percutaneous coronary intervention (PCI), blood samples were collected within 6-24h for markers related to plaque rupture (metalloproteinase 9, tissue ..
  22. Khademvatan K, Alinejad V, Eghtedar S, Rahbar N, Agakhani N. Survey of the relationship between metabolic syndrome and myocardial infarction in hospitals of Urmia University of medical sciences. Glob J Health Sci. 2014;6:58-65 pubmed publisher
    ..was not found between the marital status, education, residence, income, previous history of heart disease, PCI, LDL, history of drug use, type of infarction, the extent of ejection and location with syndrome patients...
  23. Chen H, Mruk D, Lee W, Cheng C. Regulation of spermatogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptide. FASEB J. 2017;31:3587-3607 pubmed publisher
    ..NC1 domain from the collagen ?3(IV) chain was cloned into a mammalian expression vector, pCI-neo, with and without a collagen signal peptide...
  24. James E, Leveille S, You T, Hausdorff J, Travison T, Manor B, et al. Gait coordination impairment is associated with mobility in older adults. Exp Gerontol. 2016;80:12-6 pubmed publisher
    ..of this study was to determine whether impaired gait coordination, as measured by the Phase Coordination Index (PCI), is significantly associated with mobility limitations in older adults, even after adjusting for other gait ..
  25. Bhat F, Changal K, Raina H, Tramboo N, Rather H. Transradial versus transfemoral approach for coronary angiography and angioplasty - A prospective, randomized comparison. BMC Cardiovasc Disord. 2017;17:23 pubmed publisher
    b>PCI has been done traditionally through transfemoral route. But now transradial and transbrachial routes are also coming up in practice...
  26. Kireev K, Fokin A, Krasnopeev A, Kireeva T. [Clinical and surgical gender differences in patients older than 75 years who underwent emergency percutaneous coronary intervention in acute myocardial infarction]. Adv Gerontol. 2016;29:618-623 pubmed
    ..status of patients, analysis of technical aspects of diagnostic and medical percutaneous coronary interventions (PCI), as well as the comparison of results...
  27. Heuser R. Make PCI great again: Come on USA, catch up with the rest of the world. Catheter Cardiovasc Interv. 2017;90:723 pubmed publisher
    Same day discharge after PCI lags in the USA The radial approach to PCI reduces complications compared to the femoral approach USA physicians need to seize the opportunity to not only perform PCI safely, but with economic responsibility.
  28. Graham M, Sessler D, Parlow J, Biccard B, Guyatt G, Leslie K, et al. Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery. Ann Intern Med. 2017;: pubmed publisher
    Uncertainty remains about the effects of aspirin in patients with prior percutaneous coronary intervention (PCI) having noncardiac surgery.
  29. Padala S, Sidhu M, Hartigan P, Maron D, Teo K, Spertus J, et al. Effect of baseline exercise capacity on outcomes in patients with stable coronary heart disease (a post hoc analysis of the clinical outcomes utilizing revascularization and aggressive drug evaluation trial). Am J Cardiol. 2015;116:1509-15 pubmed publisher
    ..to an initial strategy of optimal medical therapy (OMT) with or without percutaneous coronary intervention (PCI) in the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial has not been ..
  30. Andell P, Karlsson S, Mohammad M, Götberg M, James S, Jensen J, et al. Intravascular Ultrasound Guidance Is Associated With Better Outcome in Patients Undergoing Unprotected Left Main Coronary Artery Stenting Compared With Angiography Guidance Alone. Circ Cardiovasc Interv. 2017;10: pubmed publisher
    ..IVUS) guidance when performing unprotected left main coronary artery (LMCA) percutaneous coronary intervention (PCI), but the overall picture remains inconclusive and warrants further investigation...
  31. Choi H, Ahn J, Kang S, Lee P, Kang S, Lee S, et al. Prevalence, Management, and Long-Term (6-Year) Outcomes of Atrial Fibrillation Among Patients Receiving Drug-Eluting Coronary Stents. JACC Cardiovasc Interv. 2017;10:1075-1085 pubmed publisher
    ..management, and clinical relevance of atrial fibrillation (AF) during and after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and evaluate outcomes of different antithrombotic strategies...
  32. Nakagawa M, Owada Y, Izumi Y, Nonin S, Sugioka K, Nakatani D, et al. Four cases of investigational therapy with interleukin-11 against acute myocardial infarction. Heart Vessels. 2016;31:1574-8 pubmed publisher
    ..Following CAG, percutaneous coronary intervention (PCI) was performed as a standard therapy. No serious adverse drug reactions were observed...
  33. Sunagawa O, Nakamura M, Hokama R, Miyara T, Taba Y, Touma T. A case of percutaneous coronary intervention for treatment of iatrogenic chronic total occlusion of the left circumflex artery after mitral valve repair. Cardiovasc Interv Ther. 2017;32:146-150 pubmed publisher
    ..We performed percutaneous coronary intervention (PCI) and successfully placed an everolimus-eluting stent...
  34. De Luca L, Capranzano P, Patti G, Parodi G. Switching of platelet P2Y12 receptor inhibitors in patients with acute coronary syndromes undergoing percutaneous coronary intervention: Review of the literature and practical considerations. Am Heart J. 2016;176:44-52 pubmed publisher
    ..in patients with acute coronary syndromes (ACSs) and in those undergoing percutaneous coronary intervention (PCI)...
  35. Waldo S, McCabe J, Kennedy K, Zigler C, Pinto D, Yeh R. Quality of Care at Hospitals Identified as Outliers in Publicly Reported Mortality Statistics for Percutaneous Coronary Intervention. Circulation. 2017;135:1897-1907 pubmed publisher
    Public reporting of percutaneous coronary intervention (PCI) outcomes may create disincentives for physicians to provide care for critically ill patients, particularly at institutions with worse clinical outcomes...
  36. Ju L, Wen Y, Yin J, Deng S, Zheng J, Wang L, et al. Metabonomic study of the effects of different acupuncture directions on therapeutic efficacy. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1009-1010:87-95 pubmed publisher
    Posterior circulation ischemia (PCI) is a common clinical ischemic cerebrovascular disease that can endanger the lives of patients in severe cases...
  37. Wilson M, Grossestreuer A, Gaieski D, Abella B, Frohna W, Goyal M. Incidence of coronary intervention in cardiac arrest survivors with non-shockable initial rhythms and no evidence of ST-elevation MI (STEMI). Resuscitation. 2017;113:83-86 pubmed publisher
    ..The incidence of significant coronary artery disease (CAD) as defined by documented coronary intervention (i.e. PCI, angioplasty, stent or CABG) was assessed...
  38. Ye B, Liu B, Yang L, Huang G, Hao L, Xia P, et al. Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. Nat Commun. 2017;8:1518 pubmed publisher
    ..Here we show that PCI domain-containing protein 2 (Pcid2) is highly expressed in MPPs...
  39. Khalaf H, Al Meman A, Rasool S. Impact of Cytochrome P450 2C19*2 and *3 on Clopidogrel Loading Dose in Saudi Patients with Acute Coronary Syndrome. Drug Metab Lett. 2016;10:65-70 pubmed
    ..To establish a rough estimation for the safe PRU limits for short inhospital stay following PCI. A short-term experimental study was conducted with 90 patients who underwent coronary angioplasty with drug ..
  40. Zhu K, Fu Q, Zhang N, Huang Y, Zhang Q. Pre-PCI medication using clopidogrel and ticagrelor in the treatment of patients with acute myocardial infarction. Eur Rev Med Pharmacol Sci. 2015;19:4636-41 pubmed
    ..for patients with acute myocardial infarction (AMI) undergoing emergent percutaneous coronary intervention (PCI), and to investigate the efficacy and safety of these medications in the management of AMI...
  41. Jiménez Brítez G, Freixa X, Flores Umanzor E, San Antonio R, Caixal G, Garcia J, et al. Out-of-hospital cardiac arrest and stent thrombosis: Ticagrelor versus clopidogrel in patients with primary percutaneous coronary intervention under mild therapeutic hypothermia. Resuscitation. 2017;114:141-145 pubmed publisher
    ..to increased risk of Stent Thrombosis (ST) in comatose survivors who undergo percutaneous coronary intervention (PCI)...
  42. Agarwal S, Kasula S, Edupuganti M, Raina S, Shailesh F, Almomani A, et al. Clinical Decision-Making for the Hemodynamic "Gray Zone" (FFR 0.75-0.80) and Long-Term Outcomes. J Invasive Cardiol. 2017;29:371-376 pubmed
    ..had a higher prevalence of smoking and chronic kidney disease compared with the percutaneous coronary intervention (PCI) group (n = 190 [80%]; P<.05)...
  43. Pross C, Busse R, Geissler A. Hospital quality variation matters - A time-trend and cross-section analysis of outcomes in German hospitals from 2006 to 2014. Health Policy. 2017;121:842-852 pubmed publisher
    ..2006 and 2014 for cholecystectomy, pacemaker implantation, hip replacement, percutaneous coronary intervention (PCI), stroke, and acute myocardial infarction (AMI)...
  44. Huang C, Jen H, Huang W, Tsao T, Shing Young M, Yin W. The Impact of Fractional Flow Reserve-Guided Coronary Revascularization in Patients with Coronary Stenoses of Intermediate Severity. Acta Cardiol Sin. 2017;33:353-361 pubmed
    ..has not been widely accepted and limited outcome data exist about FFR-guided percutaneous coronary intervention (PCI) in Taiwan...
  45. Maccagni D, Benincasa S, Bellini B, Candilio L, Poletti E, Carlino M, et al. Noise reduction technology reduces radiation dose in chronic total occlusions percutaneous coronary intervention: a propensity score-matched analysis. Int J Cardiovasc Imaging. 2018;34:1185-1192 pubmed publisher
    Chronic total occlusions (CTO) percutaneous coronary intervention (PCI) is associated with high radiation dose...
  46. Biering K, Lund T, Andersen J, Hjollund N. Effect of Psychosocial Work Environment on Sickness Absence Among Patients Treated for Ischemic Heart Disease. J Occup Rehabil. 2015;25:776-82 pubmed publisher
    ..A cohort of patients under 67 years and treated with percutaneous coronary intervention (PCI) was established in 2006...
  47. Lai H, Chen Q, Yang Y, Ma Y, Li X, Xu R, et al. Association of mean platelet volume with impaired myocardial reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Blood Coagul Fibrinolysis. 2016;27:5-12 pubmed publisher
    ..in patients with STEMI with successful epicardial reperfusion after primary percutaneous coronary intervention (PCI)...
  48. Yaylak B, Ede H, Baysal E, Altıntas B, Akyuz S, Sevŭk U, et al. Neutrophil/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST-segment elevation myocardial infarction. Cardiol J. 2016;23:100-6 pubmed publisher
    ..and RV dysfunction (RVD) in patients with inferior STEMI who underwent primary percutaneous coronary intervention (PCI). A total of 213 subjects with inferior STEMI were divided into two groups according to the presence of RVD...
  49. Roy J, Rees D, Ramsay D, Weaver J. Late Double-Barrel Lumen Following Successful CTO-PCI Using the Crossboss Stingray System. J Invasive Cardiol. 2017;29:E28-E29 pubmed
    ..trials on long-term clinical outcomes after chronic total occlusion percutaneous coronary intervention (CTO-PCI)...
  50. Zeng R, Li S, Zhang M, Li X, Zhu C, Guo Y, et al. Remnant cholesterol predicts periprocedural myocardial injury following percutaneous coronary intervention in poorly-controlled type 2 diabetes. J Cardiol. 2017;70:113-120 pubmed publisher
    ..Whether RC is associated with periprocedural myocardial injury (PMI) following percutaneous coronary intervention (PCI) in type 2 diabetes (T2D) is currently unknown...
  51. Khan S, Khan M, Ghani A, Lone A, Arshad A, Kaluski E. Meta-Analysis of Antithrombotic Therapy in Atrial Fibrillation After Percutaneous Coronary Intervention. Am J Cardiol. 2018;121:1200-1206 pubmed publisher
    ..OAC) plus dual antiplatelet therapy (DAPT) in atrial fibrillation (AF) after percutaneous coronary intervention (PCI)...
  52. Tabata N, Hokimoto S, Akasaka T, Arima Y, Sakamoto K, Yamamoto E, et al. Differential impact of peripheral endothelial dysfunction on subsequent cardiovascular events following percutaneous coronary intervention between chronic kidney disease (CKD) and non-CKD patients. Heart Vessels. 2016;31:1038-44 pubmed publisher
    ..effect of peripheral endothelial dysfunction on cardiovascular events after percutaneous coronary intervention (PCI)...
  53. Carlino M, Azzalini L, Colombo A. A novel maneuver to facilitate retrograde wire externalization during retrograde chronic total occlusion percutaneous coronary intervention. Catheter Cardiovasc Interv. 2017;89:E7-E12 pubmed publisher
    ..the success rate and procedural efficiency of chronic total occlusion (CTO) percutaneous coronary intervention (PCI), it can still be challenging and time-consuming...
  54. De Vita A, Milo M, Sestito A, Lamendola P, Lanza G, Crea F. Association of coronary microvascular dysfunction with restenosis of left anterior descending coronary artery disease treated by percutaneous intervention. Int J Cardiol. 2016;219:322-5 pubmed publisher
    ..In this study, we assessed whether post-PCI CMVD may predict clinical outcome in patients undergoing successful elective PCI of an isolated stenosis of the ..
  55. Ahn J, Park D, Lee C, Chang M, Cavalcante R, Sotomi Y, et al. Comparison of Stenting Versus Bypass Surgery According to the Completeness of Revascularization in Severe Coronary Artery Disease: Patient-Level Pooled Analysis of the SYNTAX, PRECOMBAT, and BEST Trials. JACC Cardiovasc Interv. 2017;10:1415-1424 pubmed publisher
    ..disease undergoing coronary artery bypass grafting (CABG) and those undergoing percutaneous coronary intervention (PCI) achieving complete revascularization (CR) or incomplete revascularization...
  56. Yang L, Wang H, Zhang Y, Han T, Wang W. The Prognostic Value of Lipoprotein-Associated Phospholipase A2 in the Long-Term Care of Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. Clin Appl Thromb Hemost. 2017;:1076029617737837 pubmed publisher
    ..cardiovascular events in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), but this association has not been documented among the Chinese...
  57. Mutlu A, Alkan H, Fırat T, Karaduman A, Yilmaz O. How do physical capacity, fatigue and performance differ in children with duchenne muscular dystrophy compared with their healthy peers?. Neurosciences (Riyadh). 2018;23:39-45 pubmed publisher
    ..The Six Minute Walk Test (6MWT), Northstar Ambulatory Assessment Scale (NSAA), Physiological Cost Index (PCI), and Timed performance tests were used to assess the children...
  58. Aggarwal B, Shah G, Randhawa M, Ellis S, Lincoff A, Menon V. Utility of Glycated Hemoglobin for Assessment of Glucose Metabolism in Patients With ST-Segment Elevation Myocardial Infarction. Am J Cardiol. 2016;117:749-53 pubmed publisher
    ..Consecutive patients undergoing PCI for STEMI from January 2005 to December 2012 were included and routinely performed admission HbA1c was used to ..
  59. Strisciuglio T, Barbato E, De Biase C, Di Gioia G, Cotugno M, Stanzione R, et al. T2238C Atrial Natriuretic Peptide Gene Variant and the Response to Antiplatelet Therapy in Stable Ischemic Heart Disease Patients. J Cardiovasc Transl Res. 2018;11:36-41 pubmed publisher
    ..In patients undergoing elective percutaneous coronary intervention (PCI), loaded with antiplatelets, blood samples were withdrawn for genotyping, platelet reactivity assessment and for ..
  60. Tortoza M, Humphries T, Sheppard D, Paskevicius M, Rowles M, Sofianos M, et al. Thermodynamics and performance of the Mg-H-F system for thermochemical energy storage applications. Phys Chem Chem Phys. 2018;20:2274-2283 pubmed publisher
    ..analysis, temperature-programmed-desorption mass spectrometry and Pressure-Composition-Isothermal (PCI) analysis...
  61. Liu X, Wan Z, Zhao N, Zhang Y, Mi L, Wang X, et al. Adjustment of the GRACE score by HemoglobinA1c enables a more accurate prediction of long-term major adverse cardiac events in acute coronary syndrome without diabetes undergoing percutaneous coronary intervention. Cardiovasc Diabetol. 2015;14:110 pubmed publisher
    ..of HbA1c content in ACS patients without diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI). We enrolled 549 ACS patients without DM who underwent PCI...
  62. Imai Y, Yamashita T, Topaz O. Synergistic ELCA-aspiration-DES thrombus removal strategy-embolus impact in high-risk plaque: A case report. Medicine (Baltimore). 2017;96:e8328 pubmed publisher
    ..and red thrombus are suggested as a high-risk of embolic complications during percutaneous coronary intervention (PCI)...
  63. Rakowski T, Siudak Z, Dziewierz A, Plens K, Kleczyński P, Dudek D. Contemporary use of P2Y12 inhibitors in patients with ST-segment elevation myocardial infarction referred to primary percutaneous coronary interventions in Poland: Data from ORPKI national registry. J Thromb Thrombolysis. 2018;45:151-157 pubmed publisher
    ..Finally 19,437 patients from 122 centers (immediate PCI in 94%) were included into the analysis (lack of ticagrelor or prasugrel usage reported in 31 centers)...
  64. Li Y, Zhang Y, Qiu F, Qiu Z. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis. 2011;32:1976-83 pubmed publisher
    ..The LRG1 was found to be expressed at higher levels in urinary exosomes and lung tissue of NSCLC patients. These results suggested that LRG1 may be a candidate biomarker for non-invasive diagnosis of NSCLC in urine. ..
  65. Numasawa Y, Kohsaka S, Ueda I, Miyata H, Sawano M, Kawamura A, et al. Incidence and predictors of bleeding complications after percutaneous coronary intervention. J Cardiol. 2017;69:272-279 pubmed publisher
    Bleeding complications remain one of the most important challenges in percutaneous coronary intervention (PCI), particularly in Asians who are known to be vulnerable to the use of antiplatelets or anticoagulants...
  66. Raschi E, Bianchin M, Fantoni C, Ageno W, De Ponti F, De Ponti R. Evolving cardiovascular uses of direct-acting oral anticoagulants: a paradigm shift on the horizon?. Intern Emerg Med. 2017;12:923-934 pubmed publisher
    ..However, in the past few months, variegated multicenter trials have been published (RE-CIRCUIT, PIONEER-AF-PCI, GEMINI-ACS-1), with potential influence on clinical practice...
  67. Sun W, Grassi P, Engström Å, Sooriyaarachchi S, Ubhayasekera W, Hreinsson J, et al. N-glycans of human protein C inhibitor: tissue-specific expression and function. PLoS ONE. 2011;6:e29011 pubmed publisher
    b>Protein C inhibitor (PCI) is a serpin type of serine protease inhibitor that is found in many tissues and fluids in human, including blood plasma, seminal plasma and urine...
  68. Nakachi T, Kohsaka S, Yamane M, Muramatsu T, Okamura A, Kashima Y, et al. Impact of Hemodialysis on Procedural Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusion: Insights From the Japanese Multicenter Registry. J Am Heart Assoc. 2017;6: pubmed publisher
    Among patients treated with percutaneous coronary intervention for chronic total occlusion (CTO-PCI), patients on long-term hemodialysis are at significantly high risk for cardiovascular mortality and morbidity...
  69. Abe M, Morimoto T, Nakagawa Y, Furukawa Y, Ono K, Kato T, et al. Impact of Transient or Persistent Contrast-induced Nephropathy on Long-term Mortality After Elective Percutaneous Coronary Intervention. Am J Cardiol. 2017;120:2146-2153 pubmed publisher
    ..study population included 5,516 patients who underwent their first elective percutaneous coronary intervention (PCI) in the Coronary REvascularization Demonstrating Outcome Study in Kyoto registry cohort-2...
  70. Suzuki K, Nishioka J, Hashimoto S. Protein C inhibitor. Purification from human plasma and characterization. J Biol Chem. 1983;258:163-8 pubmed
    b>Protein C inhibitor was isolated from human plasma using conventional chromatographic technique consisting of barium citrate adsorption, polyethylene glycol fractionation, DEAE-Sepharose CL-6B treatment, ammonium sulfate fractionation, ..
  71. Gianotten J, Schimmel A, van der Veen F, Lombardi M, Meijers J. Absence of mutations in the PCI gene in subfertile men. Mol Hum Reprod. 2004;10:807-13 pubmed
    ..One of the genes that might play a role in male reproductive function is the protein C inhibitor (PCI) gene. In mice the presence of PCI is an absolute requirement for reproduction...
  72. Pate G, Gao M, Ding L, Carere R, Tyers F, Hayden R. Changing outcomes of coronary revascularization in British Columbia, 1995-2001. Can J Cardiol. 2006;22:1197-203 pubmed
    To examine outcomes following all first coronary revascularization procedures, isolated coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI) on British Columbia (BC) resident adults from 1995 to 2001.
  73. Richter V, Willner M, Henningsen J, Birnbacher L, Marschner M, Herzen J, et al. Ex vivo characterization of pathologic fluids with quantitative phase-contrast computed tomography. Eur J Radiol. 2017;86:99-104 pubmed publisher
    X-ray phase-contrast imaging (PCI) provides additional information beyond absorption characteristics by detecting the phase shift of the X-ray beam passing through material...
  74. Lee O, Ahn C, Kim J, Kim B, Ko Y, Choi D, et al. Successful Treatment of Unprotected Left Main Coronary Bifurcation Lesion Using Minimum Contrast Volume with Intravascular Ultrasound Guidance. Yonsei Med J. 2017;58:1066-1070 pubmed publisher
    ..nephropathy (CIN) is a serious complication in patients undergoing percutaneous coronary intervention (PCI), and is associated with higher morbidity and mortality...
  75. Vetrovec G. Hemodynamic Support Devices for Shock and High-Risk PCI: When and Which One. Curr Cardiol Rep. 2017;19:100 pubmed publisher
    This article addresses evolving devices and uses of hemodynamic support in the management of high-risk PCI and AMI with cardiogenic shock. Recent publications question the benefit of Intra-aortic Balloon Pump support for AMI Shock...
  76. Li L, Hong P, Jiang Z, Yang Y, Du X, Sun H, et al. Water accelerated transformation of d-limonene induced by ultraviolet irradiation and air exposure. Food Chem. 2018;239:434-441 pubmed publisher
    ..Isotopic labelling of water molecules plus GC-MS and GC-PCI-Q-TOF analyses were used to investigate the influence of water molecules on chemical transformation of d-limonene ..
  77. Wadhera R, Anderson J, Yeh R. High-Risk Percutaneous Coronary Intervention in Public Reporting States: the Evidence, Exclusion of Critically Ill Patients, and Implications. Curr Heart Fail Rep. 2017;14:514-518 pubmed publisher
    Public reporting of outcomes for percutaneous coronary intervention (PCI) is used in some states to drive improvements in care delivery and performance...
  78. Abu Assi E, Raposeiras Roubín S, Cobas Paz R, Caneiro Queija B, Martínez Reglero C, Rodríguez Rodríguez J, et al. Assessing the performance of the PRECISE-DAPT and PARIS risk scores for predicting 1-year out-of-hospital bleeding in acute coronary syndrome patients. EuroIntervention. 2017;: pubmed publisher
    ..PARIS risk scores (RSs) were recently developed to bleeding risk assessment in percutaneous coronary intervention (PCI) patients treated with dual antiplatelet therapy (DAPT)...
  79. Nosaka K, Miyoshi T, Iwamoto M, Kajiya M, Okawa K, Tsukuda S, et al. Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study. Int J Cardiol. 2017;228:173-179 pubmed publisher
    Early initiation of EPA treatment in combination with a statin within 24h after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) reduces inflammation and ventricular arrhythmia compared with ..
  80. Watanabe T, Ando K, Daidoji H, Otaki Y, Sugawara S, Matsui M, et al. A randomized controlled trial of eicosapentaenoic acid in patients with coronary heart disease on statins. J Cardiol. 2017;70:537-544 pubmed publisher
    ..We enrolled 193 CHD patients who underwent percutaneous coronary intervention (PCI) in six hospitals...
  81. Rusthoven C, Kavanagh B. Prophylactic Cranial Irradiation (PCI) versus Active MRI Surveillance for Small Cell Lung Cancer: The Case for Equipoise. J Thorac Oncol. 2017;12:1746-1754 pubmed publisher
    Prophylactic cranial irradiation (PCI) for SCLC offers a consistent reduction in the incidence of brain metastases at the cost of measurable toxicity to neurocognitive function and quality of life, in the setting of characteristic ..
  82. Fu H, Ma J, Hu M, Zhao Z, Wang Y, Miao L. [Outcome determinants in cardiac arrest patients secondary to acute myocardial infarction receiving extra-corporeal membrane oxygenation combined with percutaneous coronary intervention therapy]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017;45:867-873 pubmed publisher
    ..infarction treated with extracorporeal membrane oxygenation (ECMO) and percutaneous coronary intervention (PCI)...
  83. Kubo T, Shinke T, Okamura T, Hibi K, Nakazawa G, Morino Y, et al. Optical frequency domain imaging vs. intravascular ultrasound in percutaneous coronary intervention (OPINION trial): one-year angiographic and clinical results. Eur Heart J. 2017;38:3139-3147 pubmed publisher
    ..ultrasound (IVUS) is a widely used, conventional imaging technique for guiding percutaneous coronary intervention (PCI)...
  84. Kawase Y, Kawasaki M, Kikuchi J, Hirata T, Okamoto S, Tanigaki T, et al. Residual pressure gradient across the implanted stent: An important factor of post-PCI physiological results. J Cardiol. 2018;71:458-463 pubmed publisher
    ..to improve the accuracy of the prediction of the physiological result of percutaneous coronary intervention (PCI)...
  85. Xue C, Bian L, Xie Y, Yin Z, Xu Z, Chen Q, et al. Low fT3 is associated with diminished health-related quality of life in patients with acute coronary syndrome treated with drug-eluting stent: a longitudinal observational study. Oncotarget. 2017;8:94580-94590 pubmed publisher
    ..Every patient was prospectively interviewed at baseline and 1 year following percutaneous coronary intervention (PCI). HRQOL was assessed with the use of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36)...
  86. Akita N, Ma N, Okamoto T, Asanuma K, Yoshida K, Nishioka J, et al. Host protein C inhibitor inhibits tumor growth, but promotes tumor metastasis, which is closely correlated with hypercoagulability. Thromb Res. 2015;135:1203-8 pubmed publisher
    b>Protein C inhibitor (PCI), a member of the serine protease inhibitor family, is expressed in various human tissues, including liver and kidneys...
  87. Vaduganathan M, Harrington R, Stone G, Steg P, Gibson C, Hamm C, et al. Cangrelor Versus Clopidogrel on a Background of Unfractionated Heparin (from CHAMPION PHOENIX). Am J Cardiol. 2017;120:1043-1048 pubmed publisher
    Cangrelor is approved for use during percutaneous coronary intervention (PCI) and is administered with different parenteral anticoagulants...
  88. Prasad S, Harikrishnan S, Sanjay G, Abhilash S, Bijulal S, Kumar M, et al. Clinical Outcomes of patients with coronary artery disease who underwent FFR evaluation of intermediate coronary lesionS- COFFRS study. Indian Heart J. 2017;69:499-504 pubmed publisher
    ..Median age-57 years (range=28-78). Males=230, 90 patients were in Group 1, 175 in group 2 (PCI in 144 & CABG in 31) and 17 in group 3. Median follow-up of patients was 17.9 months (2 to 56 months)...
  89. Li Q, Wang D, Chen B. Electrocardiogram in patients with acute inferior myocardial infarction due to occlusion of circumflex artery. Medicine (Baltimore). 2017;96:e6095 pubmed publisher
    ..All of them had received percutaneous coronary intervention (PCI) within 12?hours after symptom onset...
  90. Kallel R, Hakim R, Range G. [Stent thrombosis: what's up in 2017?]. Ann Cardiol Angeiol (Paris). 2017;66:393-399 pubmed publisher
    Stent thrombosis (ST) is still a dreadful and threatening complication of percutaneous coronary intervention (PCI) with a high risk of morbi-mortality. Nevertheless, it becomes exceptional (0.6% at 1 year and 0...
  91. Harrison J, Ang L, Naghi J, Behnamfar O, Pourdjabbar A, Patel M, et al. Robotically-assisted percutaneous coronary intervention: Reasons for partial manual assistance or manual conversion. Cardiovasc Revasc Med. 2018;19:526-531 pubmed publisher
    Robotically-assisted percutaneous coronary intervention (R-PCI) is feasible for simple coronary lesions. To determine the frequency and reasons for partial manual assistance or manual conversion during R-PCI in clinical practice...
  92. Huntington J, Kjellberg M, Stenflo J. Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation. Structure. 2003;11:205-15 pubmed
    b>Protein C inhibitor (PCI) is a member of the serpin family that has many biological functions. In blood it acts as a procoagulant, and, in the seminal vesicles, it is required for spermatogenesis...