protein C inhibitor

Summary

Gene Symbol: protein C inhibitor
Description: serpin family A member 5
Alias: PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI, plasma serine protease inhibitor, acrosomal serine protease inhibitor, plasminogen activator inhibitor III, plasminogen activator inhibitor-3, protein C inhibitor, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Species: human

Top Publications

  1. pmc Structural investigation of the alpha-1-antichymotrypsin: prostate-specific antigen complex by comparative model building
    B O Villoutreix
    Technical Research Centre of Finland, Espoo, Finland
    Protein Sci 5:836-51. 1996
  2. pmc Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1
    G D Billingsley
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 52:343-53. 1993
  3. ncbi Expression of plasminogen activator inhibitors type 1 and type 3 and urokinase plasminogen activator protein and mRNA in breast cancer
    Remedios Castello
    Hospital Universitario La Fe, Valencia, Spain
    Thromb Res 120:753-62. 2007
  4. pmc Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex
    Wei Li
    Department of Haematology, Division of Structural Medicine, Thrombosis Research Unit, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 105:4661-6. 2008
  5. ncbi Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility
    S He
    Department of Medicine, The Queen Elizabeth Hospital, Birmingham University School of Medicine, Edgbaston, Birmingham B15 2TH, UK
    Mol Hum Reprod 5:513-9. 1999
  6. ncbi A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis
    S Borgmann
    Department of Internal Medicine, Ludwig Maximilians University of Munich, Ziemssenstrasse 1, Munich, D 80336, Germany
    Clin Immunol 98:244-8. 2001
  7. pmc Protein C inhibitor--a novel antimicrobial agent
    Erik Malmström
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden
    PLoS Pathog 5:e1000698. 2009
  8. doi Loss of SerpinA5 protein expression is associated with advanced-stage serous ovarian tumors
    Ingrid T G W Bijsmans
    Department of Pathology, GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Mod Pathol 24:463-70. 2011
  9. pmc Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system
    M Laurell
    Department of Clinical Chemistry, University of Lund, Malmo General Hospital, Sweden
    J Clin Invest 89:1094-101. 1992
  10. ncbi Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen
    F Espana
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    Thromb Res 64:309-20. 1991

Research Grants

  1. Scott Kinlay; Fiscal Year: 2014
  2. Edward Hannan; Fiscal Year: 2015
  3. J Matthew Brennan; Fiscal Year: 2016
  4. ACCF-STS Database Collaboration on the Comparative Effectiveness of PCI and CABG
    William S Weintraub; Fiscal Year: 2010
  5. Autogeneic Mitochondria: Surgical Cardioprotection
    James D McCully; Fiscal Year: 2013
  6. BRUCE ALAN SULLENGER; Fiscal Year: 2016
  7. KAREN ELLEN JOYNT; Fiscal Year: 2014
  8. A Pilot Clinical Study in Acute STEMI
    Weizhong Cai; Fiscal Year: 2011
  9. Jay H Traverse; Fiscal Year: 2014
  10. COMPARE Study: electroCardiographic evaluatiOn of ischeMia comParing invAsive to
    Michele M Pelter; Fiscal Year: 2011

Detail Information

Publications266 found, 100 shown here

  1. pmc Structural investigation of the alpha-1-antichymotrypsin: prostate-specific antigen complex by comparative model building
    B O Villoutreix
    Technical Research Centre of Finland, Espoo, Finland
    Protein Sci 5:836-51. 1996
    ..PSA interacts with at least two serine protease inhibitors (serpins): alpha-1-antichymotrypsin (ACT) and protein C inhibitor (PCI)...
  2. pmc Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1
    G D Billingsley
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 52:343-53. 1993
    ..alpha 1-antichymotrypsin (alpha 1ACT; AACT locus), corticosteroid-binding globulin (CBG; CBG locus), and protein C inhibitor (PCI; PCI locus) are members of the serine protease inhibitor (serpin) superfamily...
  3. ncbi Expression of plasminogen activator inhibitors type 1 and type 3 and urokinase plasminogen activator protein and mRNA in breast cancer
    Remedios Castello
    Hospital Universitario La Fe, Valencia, Spain
    Thromb Res 120:753-62. 2007
    ..Increased levels of uPA and PAI-1 are known to be associated with a poor prognosis in breast cancer. To our knowledge this is the first study of the expression and role of PAI-3 in human breast cancer tissue...
  4. pmc Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex
    Wei Li
    Department of Haematology, Division of Structural Medicine, Thrombosis Research Unit, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 105:4661-6. 2008
    b>Protein C inhibitor (PCI) is a serpin with many roles in biology, including a dual role as pro- and anticoagulant in blood...
  5. ncbi Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility
    S He
    Department of Medicine, The Queen Elizabeth Hospital, Birmingham University School of Medicine, Edgbaston, Birmingham B15 2TH, UK
    Mol Hum Reprod 5:513-9. 1999
    b>Protein C inhibitor (PCI) has been found in seminal plasma and is considered to protect intact surrounding cells and seminal plasma proteins from possible proteolytic damage...
  6. ncbi A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis
    S Borgmann
    Department of Internal Medicine, Ludwig Maximilians University of Munich, Ziemssenstrasse 1, Munich, D 80336, Germany
    Clin Immunol 98:244-8. 2001
    ..gene is part of a cluster of serine protease inhibitor (serpin) genes (AACT; alpha1-antichymotrypsin, PCI; protein C inhibitor, CBG; corticosteroid binding globulin, PIL; PI-like pseudogene) at chromosome 14q32.1...
  7. pmc Protein C inhibitor--a novel antimicrobial agent
    Erik Malmström
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden
    PLoS Pathog 5:e1000698. 2009
    b>Protein C inhibitor (PCI) is a heparin-binding serine proteinase inhibitor belonging to the family of serpin proteins. Here we describe that PCI exerts broad antimicrobial activity against bacterial pathogens...
  8. doi Loss of SerpinA5 protein expression is associated with advanced-stage serous ovarian tumors
    Ingrid T G W Bijsmans
    Department of Pathology, GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Mod Pathol 24:463-70. 2011
    ....
  9. pmc Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system
    M Laurell
    Department of Clinical Chemistry, University of Lund, Malmo General Hospital, Sweden
    J Clin Invest 89:1094-101. 1992
    An assay was developed for the measurement of human protein C inhibitor antigen (PCI) in blood plasma and other biological fluids...
  10. ncbi Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen
    F Espana
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    Thromb Res 64:309-20. 1991
    b>Protein C inhibitor (PCI) is a heparin-dependent serpin present in a native form in plasma at concentrations of 5 micrograms/mL...
  11. ncbi Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen
    A Christensson
    Department of Clinical Chemistry, Lund University, Malmo General Hospital, Sweden
    Eur J Biochem 220:45-53. 1994
    b>Protein C inhibitor (PCI), a serine-proteinase inhibitor first purified from human blood plasma, occurs at high concentrations (3-4 microM) in seminal fluid in both a high-molecular-mass and low-molecular-mass form...
  12. pmc Protein C inhibitor is expressed in tubular cells of human kidney
    K P Radtke
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037
    J Clin Invest 94:2117-24. 1994
    b>Protein C inhibitor (PCI) is a serpin that inhibits a number of proteases. PCI is found in urine and binds to kidney epithelial cells. To determine if kidney is a source of PCI, cDNA was produced from human kidney total RNA...
  13. ncbi Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor
    A Moore
    Institute of Zoology, Zoological Society of London, England
    Mol Reprod Dev 34:280-91. 1993
    ..that cDNA 134 coded for a portion of a serine protease inhibitor (serpin) closely related to plasma Protein C inhibitor. Sequencing of an additional cDNA clone (261) and Northern blot analysis confirmed that a Protein C ..
  14. ncbi Complexes of tissue kallikrein with protein C inhibitor in human semen and urine
    F Espana
    Research Center, La Fe University Hospital, Valencia, Spain
    Eur J Biochem 234:641-9. 1995
    An ELISA was developed for quantifying the complex between tissue kallikrein (tKK) and protein C inhibitor (PCI) (tKK:PCI) in seminal plasma and urine...
  15. ncbi Synthesis and ultrastructural localization of protein C inhibitor in human platelets and megakaryocytes
    M J Prendes
    Department of Vascular Biology and Thrombosis Research, Department of Histology and Embryology, University of Vienna, Vienna, Austria
    Blood 94:1300-12. 1999
    The occurrence of protein C inhibitor (PCI) in human platelets and megakaryocytes was analyzed. As judged from enzyme-linked immunosorbent assays (ELISAs), PCI was present in platelets at a concentration of 160 ng/2 x 10(9) cells...
  16. pmc Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility
    P Uhrin
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
    J Clin Invest 106:1531-9. 2000
    b>Protein C inhibitor (PCI) is a nonspecific, heparin-binding serpin (serine protease inhibitor) that inactivates many plasmatic and extravascular serine proteases by forming stable 1:1 complexes...
  17. ncbi The trimannosyl cores of N-glycans are important for the procoagulant protease-inhibitory activity of urinary protein C inhibitor
    W Izutani
    Development and Research Laboratories, JCR Pharmaceuticals Co, Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    Thromb Res 104:65-74. 2001
    ..relationship between the procoagulant protease-inhibitory activity and the N-glycan structures in urinary protein C inhibitor (uPCI) by sequential exoglycosidase digestions based on the N-glycan structures elucidated in this report...
  18. ncbi Role of each Asn-linked glycan in the anticoagulant activity of human protein C inhibitor
    Mitsugu Fujita
    Development and Research Laboratories, JCR Pharmaceuticals Co, Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    Thromb Res 105:95-102. 2002
    The N-glycosylation site mutants of human protein C inhibitor (PCI; N230S, N243Q, N319Q, N230S/N243Q, and N230S/N319Q) were prepared by amino acid replacement of the asparagine residue with a serine or glutamine residue using site-..
  19. doi Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure
    Mona Bungum
    Reproductive Medicine Centre, Malmo University Hospital, Malmo, Sweden
    Fertil Steril 93:277-9. 2010
    ..fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened ..
  20. doi Further insight into the roles of the glycans attached to human blood protein C inhibitor
    Wei Sun
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, Uppsala SE 751 23, Sweden
    Biochem Biophys Res Commun 403:198-202. 2010
    b>Protein C inhibitor (PCI) is a 57-kDa glycoprotein that exists in many tissues and secretions in human. As a member of the serpin superfamily of proteins it displays unusually broad protease specificity...
  21. ncbi Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1
    S D Mikolajczyk
    Hybritech Incorporated, a subsidiary of Beckman Coulter Inc, San Diego, CA 92196 9006, USA
    Int J Cancer 81:438-42. 1999
    ..PAI-1 inhibited hK2 comparably with protein C inhibitor (PCI) and at least 20 times more rapidly than alpha1-anti-chymotrypsin (ACT)...
  22. ncbi Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1
    Stephanie J Namciu
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A2 O25, Seattle, Washington 98109 1024, USA
    Mamm Genome 15:162-78. 2004
    ..Several differences between the MAR-Wiz predictions and the results of biochemical tests were observed. The genomic organization of the serpin gene cluster is discussed...
  23. ncbi Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma
    M G Elisen
    Department of Haematology, University Hospital and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    Blood 91:1542-7. 1998
    b>Protein C inhibitor (PCI), which was originally identified as an inhibitor of activated protein C, also efficiently inhibits coagulation factors such as factor Xa and thrombin...
  24. ncbi [Review and future perspectives on low-molecular-weight heparin]
    J P Collet
    Service de cardiologie, , 47, , 75013 Paris
    Arch Mal Coeur Vaiss 94:1233-42. 2001
    ..Direct i.v. injection of LMWH in the setting of elective PCI have also been shown to be safe and effective...
  25. ncbi Ionizing radiation and TNF-alpha and stimulated expression of alpha1-antichymotrypsin gene in human squamous carcinoma cells
    S Patel
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    Acta Oncol 37:475-8. 1998
    ..We report here that exposure of primary head and neck squamous cell carcinoma (HNSCC)-derived cells (PCI-04A) to ionizing radiation (IR) or tumor necrosis factor-alpha (TNF-alpha) resulted in an increased level of ACT ..
  26. ncbi Lung cancer
    J E Frodin
    Radiumhemmet, Stockholm, Sweden
    Acta Oncol 35:46-53. 1996
    ..Several studies are currently on-going. Prophylactic cranial irradiation (PCI) greatly reduces the risk for brain metastases from SCLC. However, it has little influence on survival...
  27. ncbi [Andermann syndrome: presentation of a case]
    I G Gurtubay
    , Hospital Virgen del Camino, Pamplona, Navarra,
    Rev Neurol 25:1087-90. 1997
    ..CLINICAL CASE: We present a 13 year old girl diagnosed as having the spastic tetraparesic type of PCI, who was sent to us so that we could reconsider the diagnosis in view of the atypical course of the illness...
  28. ncbi Treatment of small cell lung cancer. Two-drug versus four-drug chemotherapy and loco-regional irradiation with or without prophylactic cranial irradiation
    A Niiranen
    Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland
    Acta Oncol 28:501-5. 1989
    ..The patients were further randomized to receive or not to receive prophylactic cranial irradiation (PCI) 40 Gy/20 fractions/4 weeks...
  29. doi Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration
    Yolanda M Fortenberry
    Department of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1800:580-90. 2010
    Protein C inhibitor (PCI) is a plasma serine protease inhibitor (serpin) that regulates several serine proteases in coagulation including thrombin and activated protein C. However, the physiological role of PCI remains under investigation...
  30. ncbi Protein C inhibitor regulates hepatocyte growth factor activator-mediated liver regeneration in mice
    T Hamada
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
    Gut 57:365-73. 2008
    We recently reported that human protein C inhibitor (PCI), a major inhibitor of activated protein C (APC), inhibits hepatocyte growth factor activator (HGFA) by forming HGFA-PCI complexes in vitro...
  31. ncbi Combination of low molecular weight heparins with antiplatelet agents in non-ST elevation acute coronary syndromes: an update
    Marc Cohen
    Division of Cardiology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102 1192, USA
    Drugs 62:1755-70. 2002
    ..One area of new research is patients with UA/NSTEMI who later undergo percutaneous coronary interventions (PCI), and early data suggest enoxaparin can be safely used as an anticoagulant instead of UFH in these patients...
  32. ncbi Expert consensus (SBC/SBHCI) on the use of drug-eluting stents: recommendations of the Brazilian society of interventional cardiology/ Brazilian society of cardiology for the Brazilian public single healthcare system
    Valter C Lima
    Sociedade Brasileira de Hemodinâmica e Cardiologia Intervencionista, Sao Paulo, SP, Brazil
    Arq Bras Cardiol 87:e162-7. 2006
    The authors review percutaneous coronary intervention (PCI) evolution and its growing application in myocardial revascularization for patients with coronary heart disease in Brazil and worldwide...
  33. ncbi Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions
    T Hayashi
    Department of Molecular Pathobiology, Mie University School of Medicine, Tsu City, Mie, Japan
    J Thromb Haemost 2:949-61. 2004
    In humans, protein C inhibitor (PCI) is expressed in various tissues and present in many body fluids including plasma and seminal fluid. In rodents, PCI is expressed in reproductive organs only and is absent in plasma...
  34. ncbi Male fertility and protein C inhibitor/plasminogen activator inhibitor-3 (PCI): localization of PCI in mouse testis and failure of single plasminogen activator knockout to restore spermatogenesis in PCI-deficient mice
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Fertil Steril 88:1049-57. 2007
    To investigate the mechanisms responsible for the testicular abnormalities and infertility of previously generated male protein C inhibitor (PCI)-deficient mice.
  35. ncbi Protein C and its inhibitor in malignancy
    Koji Suzuki
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    Semin Thromb Hemost 33:667-72. 2007
    Activated protein C (APC) and protein C inhibitor (PCI) are the major components of the anticoagulant protein C pathway...
  36. ncbi Primary versus rescue percutaneous coronary intervention in patients with acute myocardial infarction
    G Gimelli
    Cardiology Division, Massachusetts General Hospital, Boston 02114, USA
    Acta Cardiol 55:187-92. 2000
    ..of patients with acute myocardial infarction (AMI) who underwent primary percutaneous coronary intervention (PCI) versus rescue PCI following failed thrombolysis...
  37. ncbi Trimetazidine administration minimizes myocardial damage and improves left ventricular function after percutaneous coronary intervention
    Alexandra Labrou
    2nd Cardiology Department, G Papanikolaou General Hospital, Exohi, Thessaloniki 57010, Greece
    Am J Cardiovasc Drugs 7:143-50. 2007
    ..of trimetazidine, a piperazine derivative, to patients before and after percutaneous coronary intervention (PCI) minimizes the PCI-induced myocardial damage and improves left ventricular function 1 and 3 months after the ..
  38. doi Effects of polyunsaturated omega-3 fatty acids on responsiveness to dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: the OMEGA-PCI (OMEGA-3 fatty acids after pci to modify responsiveness to dual antiplatelet therapy) st
    Grzegorz Gajos
    Department of Coronary Disease, John Paul II Hospital, Cracow, Poland
    J Am Coll Cardiol 55:1671-8. 2010
    ..to investigate whether omega-3 polyunsaturated fatty acids (PUFAs) are able to modify platelet responsiveness to dual antiplatelet therapy in stable coronary artery disease patients undergoing percutaneous coronary intervention (PCI).
  39. ncbi [The European Society of Cardiology (ESC) guidelines for percutaneous coronary interventions (PCI). Three case reports]
    Sigmund Silber
    Kardiologische Praxis und Praxisklinik in der Klinik Dr Müller, Munchen, Deutschland
    Herz 31:836-46, 848. 2006
    ..European Society of Cardiology (ESC) for the first time issued guidelines for percutaneous coronary interventions (PCI) in spring 2005...
  40. ncbi Effect of intracoronary administration of anisodamine on slow reflow phenomenon following primary percutaneous coronary intervention in patients with acute myocardial infarction
    Xiang hua Fu
    Department of Cardiology, Second Hospital of Hebei Medical University, Insistitute of Hebei Province of Cardio Cerebrovascular Disease, Shijiazhuang 050000, China
    Chin Med J (Engl) 120:1226-31. 2007
    ..may be beneficial to the improvement of slow-reflow phenomenon (SRP) following percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI)...
  41. ncbi Continuous infusion fluorouracil in the management of advanced breast cancer: a phase II study
    D Crivellari
    Division of Medical Oncology C, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    Tumori 86:42-5. 2000
    ..In particular, protracted continuous infusion (PCI) of 5-fluorouracil (5-FU) has yielded interesting results in gastrointestinal malignancies and in breast cancer...
  42. ncbi Determination of buprenorphine in human plasma by gas chromatography-positive ion chemical ionization mass spectrometry and liquid chromatography-tandem mass spectrometry
    D E Moody
    Center for Human Toxicology, University of Utah, Salt Lake City 84112, USA
    J Anal Toxicol 21:406-14. 1997
    ..Until recently, gas chromatography-positive ion chemical ionization mass spectrometry (GC-PCI-MS) offered the most sensitive method to selectively quantitate buprenorphine...
  43. ncbi Facilitated percutaneous coronary intervention (PCI) in patients with acute ST-elevation myocardial infarction: comparison of prehospital tirofiban versus fibrinolysis before direct PCI
    Martin Mockel
    Department of Cardiology, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Int J Cardiol 103:193-200. 2005
    ..as part of that strategy has led to a great deal of interest in pharmacologic reperfusion combined with mechanical reperfusion or facilitated PCI. It is not clear whether GPIIb/IIIa-blockade or fibrinolysis better facilitates PCI.
  44. ncbi Drug therapy during percutaneous coronary interventions in stable and unstable coronary artery disease: the Italian Drug Evaluation in Angioplasty (IDEA) study
    Stefano Savonitto
    A De Gasperis Cardiothoracic Department, Niguarda Ca Granda Hospital, Milan, Italy
    Ital Heart J 6:106-18. 2005
    Although periprocedural drug therapy has been shown to improve the outcome of percutaneous coronary intervention (PCI), information regarding its use in daily clinical practice is limited.
  45. ncbi Factorial phase III randomised trial of rofecoxib and prolonged constant infusion of gemcitabine in advanced non-small-cell lung cancer: the GEmcitabine-COxib in NSCLC (GECO) study
    Cesare Gridelli
    Medical Oncology, S Giuseppe Moscati Hospital, Avellino, Italy
    Lancet Oncol 8:500-12. 2007
    The addition of cyclo-oxygenase-2 (COX-2) inhibitors and prolonged constant infusion (PCI) of gemcitabine to treatment for advanced non-small-cell lung cancer (NSCLC) might improve treatment efficacy...
  46. doi [Evidence-based management of ST-segment elevation myocardial infarction (STEMI). Latest guidelines of the European Society of Cardiology (ESC) 2010]
    S Silber
    Kardiologische Praxis und Praxisklinik, Akademische Lehrpraxis der Ludwig Maximilans Universität München, Am Isarkanal 36, 81379, Munchen
    Herz 35:558-64. 2010
    ..this interval depends solely on the EMS organization and the distance to the next catheter laboratory with 24 h PCI (percutaneous coronary intervention) availability...
  47. ncbi Identification of pesticides by liquid chromatography--particle beam mass spectrometry using electron ionization and chemical ionization
    C Aguilar
    Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain
    J Chromatogr A 805:127-35. 1998
    ..under the different ionization modes, electron ionization (EI) and positive and negative chemical ionization (PCI and NCI) are compared...
  48. ncbi Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial
    A Michael Lincoff
    Department of Cardiovascular Medicine, Desk F25, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    JAMA 289:853-63. 2003
    ..thrombin inhibitor bivalirudin has been associated with better efficacy and less bleeding than heparin during coronary balloon angioplasty but has not been widely tested during contemporary percutaneous coronary intervention (PCI).
  49. ncbi Usefulness of real-time myocardial perfusion imaging to evaluate alterations of myocardial blood flow in patients with stable angina pectoris undergoing elective percutaneous coronary interventions
    Grigorios Korosoglou
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Am J Cardiol 96:885-91. 2005
    ..enzymes has been reported in patients with stable angina who undergo elective percutaneous coronary intervention (PCI) and has been associated with adverse clinical outcomes...
  50. ncbi Prospective multicenter randomized trial comparing physician versus patient transfer for primary percutaneous coronary intervention in acute ST-segment elevation myocardial infarction
    Qi Zhang
    Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Chin Med J (Engl) 121:485-91. 2008
    Primary percutaneous coronary intervention (PCI) has been identified as the first therapeutic option for patients with acute ST-segment elevation myocardial infarction (STEMI)...
  51. pmc Time from first medical contact to reperfusion in ST elevation myocardial infarction: a Which Early ST Elevation Myocardial Infarction Therapy (WEST) substudy
    Iqbal Bata
    Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Cardiol 25:463-8. 2009
    ..gap exists relating to data systematically addressing the impact of arrival at the hospital by ambulance and the delays inherent in transfer from a community hospital to tertiary centres for percutaneous coronary intervention (PCI).
  52. ncbi Prediction of contrast-induced nephropathy in diabetic patients undergoing elective cardiac catheterization or PCI: role of volume-to-creatinine clearance ratio and iodine dose-to-creatinine clearance ratio
    Surapong Worasuwannarak
    Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 93:S29-34. 2010
    ..ratio (V/CrCl) and iodine dose-to-creatinine clearance ratio (I-dose/CrCl) in predicting contrast- induced nephropathy (CIN) in diabetic patients undergoing elective cardiac catheterization or percutaneous coronary intervention (PCI).
  53. ncbi C-reactive protein plasma levels but not factor VII activity predict clinical outcome in patients undergoing elective coronary intervention
    Wilhelm Grander
    Department of Internal Medicine, Division of Cardiology, University Hospital, Leopold Franzens University, Innsbruck, Austria
    Clin Cardiol 27:211-6. 2004
    ..by C-reactive protein (CRP) and extrinsic coagulation as measured by factor VII activity (F VII) may predict clinical restenosis rate in patients with stable angina pectoris undergoing elective percutaneous coronary intervention (PCI).
  54. ncbi Is informed consent in cardiac surgery and percutaneous coronary intervention achievable?
    Marco E Larobina
    Department of Cardiothoracic Surgery, The Alfred Hospital, Melbourne, Victoria, Australia
    ANZ J Surg 77:530-4. 2007
    ..were to evaluate patients undergoing coronary artery bypass surgery (CABG) and percutaneous coronary intervention (PCI) to assess their understanding of the risks of interventions and baseline level of understanding of medical ..
  55. ncbi [Changes of serum hepatocyte growth factor before and after percutaneous coronary intervention in patients with unstable angina pectoris and significance there]
    Ning Fu Wang
    Department of Cardiology, First People s Hospital of Hangzhou, Hangzhou 310006, China
    Zhonghua Yi Xue Za Zhi 87:1411-3. 2007
    To investigate the effect of unfitrate heparin (UFH) and low molecular weight heparin (LMWH) on the expression of serum hepatocyte growth factor (HGF) during percutaneous coronary intervention (PCI).
  56. ncbi Emergency percutaneous coronary intervention (PCI) for the care of patients with ST-elevation myocardial infarction (STEMI)
    D A Morrison
    Yakima Heart Center, Yakima Regional Hospital, Yakima, WA 98902, USA
    Minerva Cardioangiol 55:593-623. 2007
    There is general consensus that emergency percutaneous coronary intervention (PCI) is the preferred treatment for patients with ST-elevation myocardial infarction (STEMI), so long as it can be delivered in a timely fashion, by an ..
  57. doi Clinical benefits of adjunctive tirofiban therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
    Jie Shen
    Department of Cardiology, Ruijin Hospital, Jiao Tong University School of Medicine, Shanghai, China
    Coron Artery Dis 19:271-7. 2008
    ..This study was conducted to investigate the clinical benefits of adjunctive tirofiban therapy combined with primary percutaneous coronary intervention (PCI) in patients with STEMI.
  58. ncbi Cardiac troponin T and I and creatine kinase-MB as markers of myocardial injury and predictors of outcome following percutaneous coronary intervention
    Thuraia Nageh
    King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Int J Cardiol 92:285-93. 2003
    ..marker for the detection of cardiac myocyte damage potentially sustained during percutaneous coronary intervention (PCI) and to assess whether such a marker can be used to identify patients at increased risk of poor subsequent clinical ..
  59. ncbi Co-delivery of plasmid-encoded cytokines modulates the immune response to a DNA vaccine delivered by in vivo electroporation
    Hung Hsun Yen
    Centre for Animal Biotechnology, Faculty of Veterinary Science, University of Melbourne, VIC 3010, Australia
    Vaccine 25:2575-82. 2007
    ..Plasmids (pCI) carrying the genes of different cytokines including ovine IL-4(pCI-IL4), IL-10(pCI-IL10), GM-CSF(pCI-GMCSF), and ..
  60. doi Incidence of and outcomes associated with ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention
    Rajendra H Mehta
    Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA
    JAMA 301:1779-89. 2009
    ..timing of sustained ventricular tachycardia or fibrillation (VT/VF) and its impact on outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) are poorly understood.
  61. pmc Factors associated with false-positive emergency medical services triage for percutaneous coronary intervention
    Pamela Yamamoto Swan
    University of California, Irvine School of Medicine, Department of Emergency Medicine, Orange, CA
    West J Emerg Med 10:208-12. 2009
    ..Services (EMS) initiated a field 12-lead program to minimize time to emergency percutaneous coronary intervention (PCI) for field-identified acute myocardial infarction (MI)...
  62. ncbi Impact of obesity on disease-specific health status after percutaneous coronary intervention in coronary disease patients
    W S Carlos Poston
    Mid America Heart Institute and University of Missouri Kansas City, MO 64110, USA
    Int J Obes Relat Metab Disord 28:1011-7. 2004
    ..surgery, but few have examined it as a risk factor among patients undergoing percutaneous coronary interventions (PCI)...
  63. ncbi Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, DUMC Box 3085, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 58:641-54. 2004
    ..radiotherapy (L+/-RT) and brain metastases after chemotherapy with or without prophylactic cranial irradiation (C+/-PCI) for small-cell lung cancer, estimates of cell killing and subclinical repopulation were tested against the results ..
  64. ncbi X-sizer for thrombectomy in acute myocardial infarction improves ST-segment resolution: results of the X-sizer in AMI for negligible embolization and optimal ST resolution (X AMINE ST) trial
    Thierry Lefevre
    Institut Cardiovasculaire Paris Sud, Massy, France
    J Am Coll Cardiol 46:246-52. 2005
    ..adjunctive thrombectomy using X-Sizer (eV3, White Bear Lake, Minnesota) before percutaneous coronary intervention (PCI) versus conventional PCI in patients with acute myocardial infarction (AMI) for <12 h and Thrombolysis In ..
  65. doi Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): a r
    Cécile Le Péchoux
    Radiotherapy Department, Institut Gustave Roussy, Villejuif, France
    Lancet Oncol 10:467-74. 2009
    The optimum dose of prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC) is unknown. A meta-analysis suggested that the incidence of brain metastases might be reduced with higher PCI doses...
  66. ncbi Predictors of in-hospital mortality in 1333 patients with acute myocardial infarction complicated by cardiogenic shock treated with primary percutaneous coronary intervention (PCI); Results of the primary PCI registry of the Arbeitsgemeinschaft Leitende K
    Uwe Zeymer
    Medizinische Klinik B, Herzzentrum Ludwigshafen, Ludwigshafen, Germany
    Eur Heart J 25:322-8. 2004
    ..cohort of consecutive patients with cardiogenic shock treated with primary percutaneous coronary intervention (PCI)...
  67. ncbi Long-term efficacy of bivalirudin and provisional glycoprotein IIb/IIIa blockade vs heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary revascularization: REPLACE-2 randomized trial
    A Michael Lincoff
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 292:696-703. 2004
    In the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)-2 trial, bivalirudin with provisional glycoprotein IIb/IIIa (Gp IIb/IIIa) inhibition was found to be noninferior to heparin plus planned Gp IIb/..
  68. ncbi Mortality after emergent percutaneous coronary intervention in cardiogenic shock secondary to acute myocardial infarction and usefulness of a mortality prediction model
    Lloyd W Klein
    Rush Medical College, Chicago, Illinois, USA
    Am J Cardiol 96:35-41. 2005
    Although percutaneous coronary intervention (PCI) in the setting of cardiogenic shock has a high in-hospital mortality rate, it has been shown to decrease the mortality rate in certain subgroups...
  69. ncbi Comparison of enoxaparin versus unfractionated heparin in patients with unstable angina pectoris/non-ST-segment elevation acute myocardial infarction having subsequent percutaneous coronary intervention
    Keith A A Fox
    Edinburgh Royal Infirmary, Edinburgh, United Kingdom
    Am J Cardiol 90:477-82. 2002
    ..in Non-Q-Wave Coronary Events (ESSENCE) trial 1,326 patients underwent percutaneous coronary intervention (PCI)...
  70. ncbi Enhancement of the immunogenicity of DNA vaccine against infectious bursal disease virus by co-delivery with plasmid encoding chicken interleukin 2
    Jianrong Li
    Institute of Preventive Veterinary Medicine, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310029, PR China
    Virology 329:89-100. 2004
    ..Coadministration of a plasmid encoding the VP2 gene of IBDV (pCI-VP2) and a plasmid encoding chicken IL-2 gene (pCI-chIL-2) enhances bursal protection against both the homologous ..
  71. ncbi Percutaneous coronary intervention in patients receiving enoxaparin or unfractionated heparin after fibrinolytic therapy for ST-segment elevation myocardial infarction in the ExTRACT-TIMI 25 trial
    C Michael Gibson
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Am Coll Cardiol 49:2238-46. 2007
    ..infarction (STEMI) who receive fibrinolytic therapy and subsequently undergo percutaneous coronary intervention (PCI) by analyzing data from the ExTRACT-TIMI 25 (Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial ..
  72. ncbi Multi-vessel stenting during primary percutaneous coronary intervention for acute myocardial infarction. A single-center experience
    A A Khattab
    Herz Kreislauf Zentrum, Segeberger Kliniken, GmbH, Am Kurpark 1, 23795, Bad Segeberg, Germany
    Clin Res Cardiol 97:32-8. 2008
    ..are, therefore, usually subjected to staged procedures, with the primary percutaneous coronary intervention (PCI) confined to recanalization of the infarct-related artery (IRA)...
  73. pmc Meta-analysis of clinical efficacy and bleeding risk with intravenous glycoprotein IIb/IIIa antagonists for percutaneous coronary intervention
    Marino Labinaz
    University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 23:963-70. 2007
    Percutaneous coronary intervention (PCI) has become the most common mode of coronary revascularization...
  74. doi Myocardial infarction after percutaneous coronary intervention: a meta-analysis of troponin elevation applying the new universal definition
    L Testa
    Institute of Cardiology, John Radcliffe Hospital, Oxford, UK
    QJM 102:369-78. 2009
    Elevation of Troponin after scheduled percutaneous coronary intervention (PCI) is a recognized consequence...
  75. doi The effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention: a BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) trial substudy
    Jacqueline Saw
    Division of Cardiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    JACC Cardiovasc Interv 1:654-9. 2008
    The purpose of this study was to evaluate the effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention (PCI) with glycoprotein (GP) IIb/IIIa blockade.
  76. doi Choice of reperfusion strategy at hospitals with primary percutaneous coronary intervention: a National Registry of Myocardial Infarction analysis
    Reza Fazel
    MSc, Emory University, Division of Cardiology, Bldg A, Suite 1 North, 1256 Briarcliff Rd NE, Atlanta, GA 30306, USA
    Circulation 120:2455-61. 2009
    Many hospitals with percutaneous coronary intervention (PCI) capability also use fibrinolytic therapy in patients with ST-segment elevation myocardial infarction, but factors influencing the choice of reperfusion strategy at these ..
  77. doi Comparison of hospital mortality with intra-aortic balloon counterpulsation insertion before versus after primary percutaneous coronary intervention for cardiogenic shock complicating acute myocardial infarction
    Mohamed Abdel-Wahab
    Heart and Vascular Center, Segeberger Kliniken GmbH, Academic Teaching Hospital of the University of Kiel, Bad Segeberg, Germany
    Am J Cardiol 105:967-71. 2010
    Primary percutaneous coronary intervention (PCI) and intra-aortic balloon pump counterpulsation (IABP) are established treatment modalities in acute myocardial infarction complicated by cardiogenic shock...
  78. ncbi Periodic current injection (PCI)--a new method to image steady-state membrane potential of single neurons in situ using extracellular voltage-sensitive dyes
    A Borst
    Friedrich Miescher Laboratorium, Max Planck Gesellschaft, , Bundesrepublik Deutschland
    Z Naturforsch C 50:435-8. 1995
    ..of the voltage-sensitive dye while the neuron's membrane potential is shifted by a periodic current injection (PCI)...
  79. ncbi Large and small vessel vasoconstriction following coronary artery stenting. Effect of intra coronary nitroglycerine and relation to LDL cholesterol
    Alf Inge Larsen
    University of Bergen, Cardiology Division, Stavanger University Hospital, N 4001 Stavanger, Norway
    Int J Cardiol 113:61-5. 2006
    Percutaneous coronary intervention (PCI) with stent placement induces epicardial coronary vasoconstriction, which is resolved by intracoronary (IC) nitroglycerine (NTG)...
  80. doi Frequency of stress testing to document ischemia prior to elective percutaneous coronary intervention
    Grace A Lin
    Division of General Internal Medicine, University of California, San Francisco, USA
    JAMA 300:1765-73. 2008
    Guidelines call for documenting ischemia in patients with stable coronary artery disease prior to elective percutaneous coronary intervention (PCI).
  81. pmc Systematic review of fibrinolytic-facilitated percutaneous coronary intervention: potential benefits and future challenges
    J Afilalo
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Can J Cardiol 25:141-8. 2009
    Facilitated percutaneous coronary intervention (PCI) is defined as the administration of fibrinolytic therapy and/or glycoprotein (GP) IIb/IIIa inhibitors to minimize myocardial ischemia time while waiting for PCI...
  82. doi Effect of two-day atorvastatin pretreatment on the incidence of periprocedural myocardial infarction following elective percutaneous coronary intervention: a single-center, prospective, and randomized study
    Josef Veselka
    Department of Cardiology, Cardiovascular Center, University Hospital, Charles University Motol Medical School I, Prague, Czech Republic
    Am J Cardiol 104:630-3. 2009
    ..myocardial infarction (PMI) in patients with stable angina during elective percutaneous coronary intervention (PCI). The purpose of this randomized study (Clinical Trial Registration No...
  83. doi Randomized comparison of percutaneous coronary intervention with coronary artery bypass grafting in diabetic patients. 1-year results of the CARDia (Coronary Artery Revascularization in Diabetes) trial
    Akhil Kapur
    London Chest Hospital, Barts and The London NHS Trust, Imperial College, London, England
    J Am Coll Cardiol 55:432-40. 2010
    The purpose of this study was to compare the safety and efficacy of percutaneous coronary intervention (PCI) with stenting against coronary artery bypass grafting (CABG) in patients with diabetes and symptomatic multivessel coronary ..
  84. doi Impact of hospital proportion and volume on primary percutaneous coronary intervention performance in England and Wales
    Robert M West
    Centre for Epidemiology and Biostatistics, University of Leeds, Level 8, Worsley Building, Clarendon Way, West Yorkshire, Leeds LS2 9JT, UK
    Eur Heart J 32:706-11. 2011
    To quantify the determinants of primary percutaneous coronary intervention (PCI) performance in England and Wales between 2004 and 2007.
  85. doi The Bypass Angioplasty Revascularization in Type 1 and Type 2 Diabetes Study: 5-year follow-up of revascularization with percutaneous coronary intervention versus coronary artery bypass grafting in diabetic patients with multivessel disease
    Akhil Kapur
    Barts and The London NHS Trust, London, UK
    J Cardiovasc Med (Hagerstown) 11:26-33. 2010
    ..Angioplasty Revascularization in Type 1 and Type 2 Diabetes study was to assess percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) as treatments for multivessel coronary artery disease in diabetic ..
  86. ncbi Determination of traces of five antifouling agents in water by gas chromatography with positive/negative chemical ionisation and tandem mass spectrometric detection
    M D Hernando
    Pesticide Residue Research Group, University of Almeria, Spain
    J Chromatogr A 938:103-11. 2001
    ..spectrometer provided with an external ion source that allows the combined use, in the same analysis, of positive (PCI) and negative (NCI) chemical ionisation and tandem mass spectrometric fragmentation (MS-MS)...
  87. ncbi Combination Enoxaparin and Abciximab During Percutaneous Coronary Intervention: A New Standard of Care?
    - Kereiakes
    Lindner Center for Research and Education, 2123 Auburn Avenue, Suite 424, Cincinnati, OH 45219, USA
    Curr Interv Cardiol Rep 2:157-164. 2000
    ..of platelet glycoprotein (GP) IIb/IIIa blockade both to patients undergoing percutaneous coronary intervention (PCI) and those presenting with non-ST elevation acute coronary syndromes (ACSs)...
  88. ncbi Safety of coronary stenting with eptifibatide and ultra-low-dose heparin
    Michel Le May
    The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Am J Cardiol 95:630-2. 2005
    With the advent of multiple potent antiplatelet and anticoagulation agents in percutaneous coronary intervention (PCI), the risk of bleeding complications has increased...
  89. pmc Multivariate prediction of major adverse cardiac events after 9914 percutaneous coronary interventions in the north west of England
    A D Grayson
    The Cardiothoracic Centre, Liverpool L14 3PE, UK
    Heart 92:658-63. 2006
    To develop a multivariate prediction model for major adverse cardiac events (MACE) after percutaneous coronary interventions (PCIs) by using the North West Quality Improvement Programme in Cardiac Interventions (NWQIP) PCI Registry.
  90. ncbi Evaluation of repeated measurements of radon-222 concentrations in well water sampled from bedrock aquifers of the Piedmont near Richmond, Virginia, USA: effects of lithology and well characteristics
    Shelley A Harris
    Department of Epidemiology and Community Health, Virginia Commonwealth University, P O Box 843050, Richmond, VA 23284 3050, USA
    Environ Res 101:323-33. 2006
    ..Statistically significant differences in GWRC were found in the Trssu (1482 +/- 1711 pCi/L) and Mpg (7750 +/- 5188 pCi/L) lithologies, however, no significant differences were found among GWRC at each ..
  91. doi Predictors of slow flow during primary percutaneous coronary intervention: an intravascular ultrasound-virtual histology study
    J H Bae
    Division of Cardiology, College of Medicine, Konyang University Hospital, Seo Gu, Daejeon, South Korea
    Heart 94:1559-64. 2008
    Slow flow phenomenon is a serious complication of percutaneous coronary intervention (PCI) and is associated with a poor prognosis...
  92. pmc CYP2E1 overexpression inhibits microsomal Ca2+-ATPase activity in HepG2 cells
    Andres A Caro
    Hendrix College, Chemistry Department, 1600 Washington Avenue, Conway, AR 72032, USA
    Toxicology 255:171-6. 2009
    ..were isolated by differential centrifugation from two liver cell line: E47 cells (HepG2 cells transfected with the pCI neo expression vector containing the human CYP2E1 cDNA, which overexpress active microsomal CYP2E1), and control ..
  93. ncbi [The safety and outcome of patients with acute myocardial infarction transferred for primary angioplasty]
    Li kun Ma
    Department of Cardiology, Anhui Provincial Hospital, Hefei 230001, China
    Zhonghua Xin Xue Guan Bing Za Zhi 36:485-8. 2008
    To evaluate the safety and outcome of patients with acute myocardial infarction (AMI) transferred for primary percutaneous coronary intervention (PCI).
  94. ncbi Comparison of primary angioplasty in rural and metropolitan areas within an integrated network
    Gabriele Giuliani
    Invasive Cardiology 2, Careggi Hospital, Florence, Italy
    EuroIntervention 4:365-72. 2008
    To compare reperfusion times and in-hospital outcome of patients with STEMI treated with primary percutaneous coronary intervention (PCI) in a teaching hospital (TH) with or without inter-hospital transfer and in community hospitals.
  95. doi Feasibility of complex coronary intervention in combination with percutaneous aortic valve implantation in patients with aortic stenosis using percutaneous left ventricular assist device (TandemHeart)
    Nicolo Piazza
    Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Catheter Cardiovasc Interv 73:161-6. 2009
    ..light of the evolution of percutaneous aortic valve implantation (PAVI) and ongoing improvements in techniques of PCI, a combined approach using PCI and PAVI can be proposed for patients with complex coronary artery and aortic valve ..
  96. doi Routine early angioplasty after fibrinolysis for acute myocardial infarction
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, ON, Canada
    N Engl J Med 360:2705-18. 2009
    ..who present to hospitals that do not have the capability of performing percutaneous coronary intervention (PCI) often cannot undergo timely primary PCI and therefore receive fibrinolysis...
  97. doi All-cause readmission and repeat revascularization after percutaneous coronary intervention in a cohort of medicare patients
    Jeptha P Curtis
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Coll Cardiol 54:903-7. 2009
    The purpose of this study was to report on the all-cause readmission and repeat revascularization rates after percutaneous coronary intervention (PCI).
  98. doi Red cell distribution width (RDW) as a predictor of long-term mortality in patients undergoing percutaneous coronary intervention
    Shyam Poludasu
    Division of Cardiology, Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Thromb Haemost 102:581-7. 2009
    ..current study evaluated the prognostic utility of RDW in patients undergoing percutaneous coronary intervention (PCI). We evaluated 859 patients who underwent PCI during January 2003 to August 2005...
  99. ncbi Embolized stent in the coronary circulation "without riding the wire" and its novel management strategy
    Afzalur Rahman
    Department of Cardiology, National Institute of Cardiovascular Diseases, Sherebangla Nagar, Dhaka 1207, Bangladesh
    J Invasive Cardiol 21:E201-3. 2009
    We report a unique technique for retrieval of a coronary stent, embolized during percutaneous coronary intervention (PCI), using conventional angioplasty wires and angioplasty balloon catheters...
  100. pmc Twenty-year evolution of percutaneous coronary intervention and its impact on clinical outcomes: a report from the National Heart, Lung, and Blood Institute-sponsored, multicenter 1985-1986 PTCA and 1997-2006 Dynamic Registries
    Lakshmi Venkitachalam
    Cardiovascular Institute, Department of Medicine, School of Medicine, University of Pittsburgh, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Circ Cardiovasc Interv 2:6-13. 2009
    Percutaneous coronary intervention (PCI) has undergone rapid progress, both in technology and adjunct therapy. However, documentation of long-term temporal trends in relation to contemporary practice is lacking.

Research Grants69

  1. Scott Kinlay; Fiscal Year: 2014
    ..therapy (>12 months) versus <12 months among Veterans following percutaneous coronary interventions (PCI) with coronary stenting...
  2. Edward Hannan; Fiscal Year: 2015
    ..portion of our country's health expenditures, with an estimated $68 billion for hospital charges for PCI procedures...
  3. J Matthew Brennan; Fiscal Year: 2016
    ..that builds on the successful piloting of the National Cardiovascular Research Infrastructure (NCRI) by the SAFE-PCI for Women Trial...
  4. ACCF-STS Database Collaboration on the Comparative Effectiveness of PCI and CABG
    William S Weintraub; Fiscal Year: 2010
    ..effectiveness of the two forms of coronary revascularization therapy, percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery...
  5. Autogeneic Mitochondria: Surgical Cardioprotection
    James D McCully; Fiscal Year: 2013
    ..percutaneous coronary intervention for coronary revascularization for ST segment elevation myocardial infarction (PCI-STEMI)...
  6. BRUCE ALAN SULLENGER; Fiscal Year: 2016
    ..therapy is required to perform a number of clinical procedures including percutaneous coronary interventions (PCI, "angioplasties"), coronary artery bypass graft (CABG) surgery and other surgeries, as well as dialysis...
  7. KAREN ELLEN JOYNT; Fiscal Year: 2014
    ..procedures for which outcomes are publicly reported at the hospital level is percutaneous coronary intervention (PCI);both New York State (NY) and Massachusetts (MA) have instituted statewide reporting of mortality rates for this ..
  8. A Pilot Clinical Study in Acute STEMI
    Weizhong Cai; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Percutaneous coronary intervention (PCI) has become the mainstay for treatment of ST-segment elevation myocardial infarction (STEMI)...
  9. Jay H Traverse; Fiscal Year: 2014
    ..Summary/Abstract Rapid restoration of blood flow of an occluded coronary artery by angioplasty and stenting (PCI) is the most effective therapy for reducing infarct size in ST-segment elevation myocardial infarction (STEMI)...
  10. COMPARE Study: electroCardiographic evaluatiOn of ischeMia comParing invAsive to
    Michele M Pelter; Fiscal Year: 2011
    ..studies, in patients with NSTEMI/UA, suggest that an early invasive strategy (percutaneous coronary interventions [PCI/stent]) might not be better than management with medications alone...
  11. Tissue Repair During Acute Phase of Myocardial Infarction
    MANLEY TF HUANG; Fiscal Year: 2010
    ..Thrombolysis and percutaneous intervention (PCI) are used to reperfuse the ischemic tissue and stabilize damage caused by infarction...
  12. Antiplatelet Therapy: Platelet Inhibition, Polymorphisms, and Protein Biomarkers
    Marc S Sabatine; Fiscal Year: 2012
    ..of prolonged dual antiplatelet therapy (aspirin and a thienopyridine) after percutaneous coronary intervention (PCI) and correlate these measures with clinical outcomes, including death, myocardial infarction, stroke, stent ..
  13. Triage and Allocation Model for Primary PCI After STEMI
    Thomas W Concannon; Fiscal Year: 2012
    ..will identify optimal strategies for increasing population access to primary percutaneous coronary intervention (PCI)...
  14. JOSHUA PATRICK LEWIS; Fiscal Year: 2016
    ..outcomes in patients with acute coronary syndrome and/or undergoing percutaneous coronary intervention (PCI)...
  15. Center for Cardiovascular Outcomes Research at Yale University
    HARLAN MARC KRUMHOLZ; Fiscal Year: 2013
    ..reported measures for acute myocardial infarction (AMI), heart failure (HF), percutaneous coronary intervention (PCI), and internal cardioverter defibrillators (ICD);to investigate hospital and regional performance using novel ..
  16. Occluded Artery Trial: Long Term Follow-Up
    Judith S Hochman; Fiscal Year: 2010
    ..designed to provide the medical community with definitive data on the risks and benefits of a strategy of routine PCI of persistently occluded infarct-related arteries in stable patients last post-Mi...
  17. Improving Adherence to Post PCI Antiplatelet Theraphy in Minority Populations
    Ana Maria Palacio; Fiscal Year: 2010
    ..the prevention of CVD secondary outcomes among disparity populations who have undergone coronary artery stenting (PCI)...
  18. Occluded Artery Trial: Long-Term Follow up-Data Coordinating Center
    Sandra Forman; Fiscal Year: 2010
    ..designed to provide the medical community with definitive data on the risks and benefits of a strategy of routine PCI of persistently occluded infarct-related arteries in stable patients late post-MI...
  19. Rachel Ruckdeschel Smith; Fiscal Year: 2015
    ..e. PCI [percutaneous coronary intervention]), rapidly after restoration of blood flow (or reperfusion), as a ..
  20. Rahul K Khare; Fiscal Year: 2014
    ..Khare will focus on one key quality indicator score in the ED: "time-to- percutaneous intervention (PCI)" quality indicator score for acute ST-elevation myocardial infarction (STEMI) patients...
  21. Understanding the implementation of new practices in health care organizations
    Ingrid Nembhard; Fiscal Year: 2013
    ..e., time between hospital arrival and balloon inflation during primary percutaneous coronary intervention (PCI)) for patients with ST-segment elevation myocardial infarction (STEMI), a common type of heart attack...
  22. High efficiency Hyper/Hypothermia
    William J Ohley; Fiscal Year: 2010
    ..instituted rapidly in the Emergency Department, during the typical period of delay associated with preparations for PCI (Percutaneous Coronary Intervention)...
  23. PARP inhibitor therapy for acute myocardial infarction
    Andrew Salzman; Fiscal Year: 2003
    ..dysfunction and inflammatory response in patients with STEMI undergoing primary percutaneous coronary intervention (PCI)...
  24. RESCUE: Randomized Evaluation of Patients with Stable Angina Comparing Utilizatio
    Arthur E Stillman; Fiscal Year: 2010
    ..difference in outcomes in comparison to individuals treated with both OMT and percutaneous coronary intervention (PCI)...
  25. Hormones and Sexual Function Predict Outcomes in Revascularized Men with Diabetes
    MARY A MCLAUGHLIN; Fiscal Year: 2013
    ..cardiovascular and cerebrovascular events in men with diabetes following [percutaneous coronary intervention (PCI)]...
  26. Long-Term Survival Following Coronary Revascularizations
    Edward Hannan; Fiscal Year: 2010
    ..e., coronary artery bypass graft (CABG) surgery and percutaneous coronary interventions (PCI)) are among the most frequently performed procedures in the United States, with an estimated 1.3 million PCIs and 0...
  27. Hybrid revascularization vs percutaneous coronary intervention: A Planning Grant
    JOHN DANIEL contact PUSKAS; Fiscal Year: 2010
    ..disease (CAD), ongoing innovation in coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI) and medical therapy, as well as the costs of revascularization have stimulated rising interest in optimal ..
  28. ALOKE VIRMANI FINN; Fiscal Year: 2014
    ..Major advances in PCI and medical therapies have created a serious disconnect between the eagerness to use new medical devices such as ..
  29. Using Clinically-Enhanced Claims Data to Guide Selection of Coronary Procedures
    HAROLD KILBURN; Fiscal Year: 2010
    ..effectiveness of coronary artery bypass graft (CABG) procedures and percutaneous coronary artery interventions (PCI)...
  30. Alyssa Panitch; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The number of percutaneous coronary intervention (PCI) procedures, commonly known as balloon angioplasty, has increased by 30% over the past 10 years totaling more than 1.3 million patients in the U...
  31. Improved Estimates of the Comparative Treatment Effects of CABG and PCI
    Mark A Hlatky; Fiscal Year: 2010
    ..Better methods to use electronic data collected in routine practice will help compare the benefits and risks of treatments in routine medical care settings. ..
  32. MicroRNA Detargeting Novel Therapy for Coronary Artery Disease
    Hana Totary-Jain; Fiscal Year: 2012
    ..The introduction of the Drug-Eluting Stent (DES) in 2002 revolutionized the field of PCI, by significantly reducing rates of restenosis when compared to bare-metal stents (BMS)...
  33. Pinar Karaca-Mandic; Fiscal Year: 2014
    ..I will estimate the consequences of physicians'use of new stents on patients' outcomes following stent insertion, such as rates of re-admissions, repeat percutaneous coronary interventions (PCI), and mortality.
  34. Coronary Post-Dilatation Catheter
    MARK CHRISTIAN SVENDSEN; Fiscal Year: 2013
    ..Patients with stable and acute coronary conditions are often treated with percutaneous coronary intervention (PCI), including stenting...
  35. Moral Hazard in Less Invasive Surgical Technology for Coronary Artery Disease
    Michael Grossman; Fiscal Year: 2011
    ..Percutaneous coronary intervention (PCI)--the newer and less invasive procedure-- and coronary artery bypass graft (CABG) surgery are the surgical ..
  36. Differences in Quality, Cost, and Access between VA and Fee Basis CABG and PCI
    THOMAS MCMILLIN MADDOX; Fiscal Year: 2013
    ..19% of the elective Coronary Artery Bypass Graft (CABG) and 22% of the elective Percutaneous Coronary Intervention (PCI) that it sponsors for veterans under age 65. Half of this care is provided to rural veterans...
  37. Development of an antidote-controlled FIXa inhibitor
    Christopher Rusconi; Fiscal Year: 2004
    ..coronary artery bypass graft (CABG) surgery and other "open-heart" surgeries, percutaneous coronary interventions (PCI, "angioplasties"), and dialysis; and is also used as a treatment for a number of thrombotic diseases including ..
  38. TNF-INHIBITOR GENE THERAPY FOR NEOINTIMAL HYPERPLASIA
    Karsten Peppel; Fiscal Year: 2004
    Percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) are each performed on approximately 500,000 patients annually in the US...
  39. Tree-Structured Prediction Model for Outcomes after PCI
    Abdissa Negassa; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Tree-structured Prediction Model for Outcomes after PCI With increasing operator experience, refinement in technology, and the availability of improved stent designs, precutaneous ..
  40. Transforming PCI Informed Consent into an Evidence-based Decision-making Tool
    John A Spertus; Fiscal Year: 2010
    ..of a new mechanism for eliciting informed consent from patients undergoing percutaneous coronary intervention (PCI) on patients'comprehension of procedural risks/benefits and upon clinicians'use of effective strategies ..
  41. Zsolt Bagi; Fiscal Year: 2014
    ..of no-reflow phenomenon - a poorly understood and unpredictable complication of percutaneous coronary intervention (PCI) in which diminished blood flow to distal microvascular beds persists despite the successful treatment of the ..
  42. PAI-1 and Vitronectin in Failure of Coronary Revascularization
    William P Fay; Fiscal Year: 2013
    ..cell (VSMC) migration and intimal hyperplasia, which cause restenosis after percutaneous coronary intervention (PCI) and are central processes in the development of atherosclerosis and other human vascular diseases...
  43. Jonathan N Myers; Fiscal Year: 2014
    ..Over the last decade, the use of percutaneous coronary intervention (PCI) has increased exponentially. Between 1996 and 2007, the number of PCIs performed in the U.S...
  44. Pediatric Percutaneous Cochlear Implantation Clinical Validation &Implementation
    Robert F Labadie; Fiscal Year: 2012
    ..adult project (R01 DC008408), we have demonstrated the feasibility of percutaneous cochlear implantation (PCI). PCI reduces CI surgery to a single pass of a drill from the lateral skull base to the cochlea...
  45. AMY JO JOHNSON; Fiscal Year: 2016
    ..this, we were first to pursue and demonstrate that the orally bioavailable, irreversible Btk inhibitor ibrutinib (PCI-32765) promotes direct apoptosis, inhibits cell proliferation, and blocks microenvironment stromal signals ..
  46. Robert F Labadie; Fiscal Year: 2016
    ..NIH-funded project (R01 DC008408), we have demonstrated the feasibility of percutaneous cochlear implantation (PCI). PCI reduces CI surgery to a single pass of a drill from the lateral skull surface to the cochlea...
  47. TOSCA-2 An Angiographic Substudy of the Occluded Arter*
    Vladimir Dzavik; Fiscal Year: 2004
    ..recanalization on LV function,, and 3) to study the effect of duration of occlusion on changes in LV function after PCI in this setting. Operations. The substudv will be conducted in 21 OAT participating centers...
  48. Athan Kuliopulos; Fiscal Year: 2016
    ..of coronary artery thrombotic events during acute coronary syndrome (ACS) and percutaneous coronary interventions (PCI) are critically dependent on reactive platelets...
  49. Robert Yeh; Fiscal Year: 2016
    ..and personalized application of antiplatelet therapy for patients undergoing percutaneous coronary intervention (PCI, or coronary angioplasty and stenting)...
  50. Pathogenesis of ADPKD-role of the transcriptional modulator TAZ
    M Amin Arnaout; Fiscal Year: 2010
    ..Dominant Polycystic Kidney Disease (ADPKD) is caused by mutations in PKD1or PKD2, the genes encoding polycystin-1 (PCI) and polycystin-2 (PC2), respectively...
  51. Paul S Fishman; Fiscal Year: 2014
    ..A promising method is photochemical internalization (PCI) where a photosensitizing molecule and appropriate wavelength of light results in release of CPP-linked proteins ..
  52. Biomarkers of Prognosis and Response to Therapy in Acute Coronary Syndromes
    Marc S Sabatine; Fiscal Year: 2010
    ..the time of presentation, (b) after clinical stabilization, and (c) following percutaneous coronary intervention (PCI). In Aim 2 we will investigate the prognostic significance of novel circulating protein and metabolic biomarkers...
  53. MOLECULAR MECHANISM OF THROMBIN INHIBITION
    Scott Cooper; Fiscal Year: 2003
    ..this research is to better understand the different mechanisms by which the serpins antithrombin (AT) and protein C inhibitor (PCI) inhibit free thrombin and thrombin bound to thrombomodulin (TM)...
  54. Autophagy, Adenosine and Pyruvate Protection During Heart Surgery
    Robert M Mentzer; Fiscal Year: 2012
    ..are major short and long term causes of morbidity and mortality after percutaneous coronary interventions (PCI), reparative heart surgery, and heart transplantation...
  55. ALEKSEY GREGORY KAZANTSEV; Fiscal Year: 2014
    ..Hit optimization in neuronal PCI 2 cells yielded two sulfobenzoic acid derivatives, 02-8 and AK-1, as potential therapeutic leads...
  56. PAUL SHEUNG YAN CHAN; Fiscal Year: 2014
    ..for coronary revascularization to support the rational and judicious use of percutaneous coronary intervention (PCI)...
  57. STUART ALEXANDER SCOTT; Fiscal Year: 2016
    ..for patients with acute coronary syndromes (ACS) and/or for those undergoing percutaneous coronary intervention (PCI)~ however, substantial interindividual variability in platelet inhibition and clinical response is commonly ..
  58. Steven M Devine; Fiscal Year: 2016
    ..Another novel compound, PCI-32765 is a first-in-class selective inhibitor of Bruton's Tyrosine Kinase (BTK) which in a phase 1 study led ..
  59. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
    ..patients that is testing the hypothesis that mechanical reperfusion of an occluded IRA with PTCA and stenting (PCI) 3-28 days after AMI in high risk patients will reduce a composite endpoint of mortality, recurrent MI, and ..
  60. Patient Safety and Acute Kidney Injury
    Jeremiah R Brown; Fiscal Year: 2013
    ..RESEARCH: Patient safety in percutaneous coronary interventions (PCI) is a problem that affects over 1.2 million patients each year in the United States...
  61. The role of the von-Hippel Lindau protein in developmental cell death in neurons
    KATHLEEN M MCAVOY; Fiscal Year: 2011
    ..confers a survival advantage to nerve growth factor (NGF)-deprived sympathetic- neuron-like pheochromocytoma cells (PCI 2 cells)...
  62. Surgeon Human Capital Depreciation Impacts on Resource Use and Patient Outcomes
    Jason Hockenberry; Fiscal Year: 2011
    ..We are going to examine the two most common surgical procedures used to treat coronary artery disease, CABG and PCI, as well as AAA repair surgery, carotid endarterectomy and aortic valve repair. There are two secondary aims...
  63. Daniel H Lowenstein; Fiscal Year: 2015
    ..A critical aspect of this enterprise, and the main goal of the Epi4K Phenotyping and Clinical Informatics (PCI) Core described here, is to assemble, organize and validate the phenotypic information on all patients proposed for ..
  64. Subhash Banerjee; Fiscal Year: 2014
    ..In this multi-center trial 114 ACS patients undergoing percutaneous coronary intervention (PCI) will be randomized to either initial LDL-apheresis and an oral daily dose of 20mg of Atorvastatin (ILLT group) or ..
  65. ROBERTO IRENARDO VAZQUEZ PADRON; Fiscal Year: 2015
    PROJECT SUMMARY Percutaneous coronary intervention (PCI) is the mainstay treatment to unblock atherosclerotic arteries...
  66. Jens Meiler; Fiscal Year: 2015
    ..through a new scoring func- tion that uses Knowledge-Based Potentials that capture Partial Covalent Interactions (PCI-KBP) at protein- ligand interfaces...
  67. PREVENTING CONTRAST-INDUCED NEPHROPATHY
    Ali Hassan; Fiscal Year: 2009
    Life saving imaging-based percutaneous coronary intervention (PCI) catheterization procedures such as stent implantation, angioplasty, and diagnostic angiography require frequent and large injections of radiopaque contrast agents in ..
  68. Blood Pressure and Risks of Cardiac Catheterization
    Cheryl Dumont; Fiscal Year: 2005
    ..access site complications post percutaneous diagnostic cardiac catheterization (CC) and coronary intervention (PCI)...
  69. TRANSCAPILLARY MACROMOLECULE MOVEMENT IN SKELETAL MUSCLE
    Matthew Wolf; Fiscal Year: 1992
    ..IO) method determines sigma d from the ratio of the change in the isogravimetric capillary pressure (Pci) to the imposed change in the macromolecule osmotic pressure in an individual experiment...