prostate specific antigen

Summary

Gene Symbol: prostate specific antigen
Description: kallikrein related peptidase 3
Alias: APS, KLK2A1, PSA, hK3, prostate-specific antigen, P-30 antigen, gamma-seminoprotein, kallikrein-3, semenogelase, seminin
Species: human
Products:     prostate specific antigen

Top Publications

  1. Samzadeh M, Hasanzad M, Jamaldini S, Haghdoost A, Afshari M, Ziaee S. Association of G/A polymorphism, rs266882, in AREI region of the prostate-specific antigen gene with prostate cancer risk and clinicopathological features. Urol J. 2012;9:691-9 pubmed
    To determine the association of prostate-specific antigen (PSA) 158A/G polymorphism with clinicopathologic characteristics of the disease and prostate cancer (PCa) risk...
  2. Ben Jemaa A, Bouraoui Y, Sallami S, Banasr A, Ben Rais N, Ouertani L, et al. Co-expression and impact of prostate specific membrane antigen and prostate specific antigen in prostatic pathologies. J Exp Clin Cancer Res. 2010;29:171 pubmed publisher
    The present study was undertaken to relate the co-expression of prostate-associated antigens, PSMA and PSA, with the degree of vascularization in normal and pathologic (hyperplasia and cancer) prostate tissues to elucidate their possible ..
  3. Malm J, Hellman J, Hogg P, Lilja H. Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor. Prostate. 2000;45:132-9 pubmed
    In semen, prostate-specific antigen (PSA or hK3) digests the gel proteins semenogelin I and II, resulting in liquefaction and the release of motile spermatozoa...
  4. Gan L, Lee I, Smith R, Argonza Barrett R, Lei H, McCuaig J, et al. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene. 2000;257:119-30 pubmed
    ..The proteases, excluding the kallikrein genes, share approximately 40% of their sequences suggesting that the serine protease gene cluster on chromosome 19q13 arose from ancient gene duplications. ..
  5. dos Santos R, de Jesus C, Trindade Filho J, Trindade J, de Camargo J, Rainho C, et al. PSA and androgen-related gene (AR, CYP17, and CYP19) polymorphisms and the risk of adenocarcinoma at prostate biopsy. DNA Cell Biol. 2008;27:497-503 pubmed publisher
    The aim of the present study was to examine the impact of polymorphisms in prostate-specific antigen (PSA) and androgen-related genes (AR, CYP17, and CYP19) on prostate cancer (PCa) risk in selected high-risk patients who underwent ..
  6. Wang L, Sato K, Tsuchiya N, Yu J, Ohyama C, Satoh S, et al. Polymorphisms in prostate-specific antigen (PSA) gene, risk of prostate cancer, and serum PSA levels in Japanese population. Cancer Lett. 2003;202:53-9 pubmed
    Recent studies have indicated that the prostate-specific antigen (PSA) gene polymorphisms may be associated with the risk of prostate cancer in Caucasian populations...
  7. Jesser C, Mucci L, Farmer D, Moon C, Li H, Gaziano J, et al. Effects of G/A polymorphism, rs266882, in the androgen response element 1 of the PSA gene on prostate cancer risk, survival and circulating PSA levels. Br J Cancer. 2008;99:1743-7 pubmed publisher
    Prostate-specific antigen (PSA) is a protease produced in the prostate that cleaves insulin-like growth factor binding protein-3 and other proteins...
  8. Cohen P, Graves H, Peehl D, Kamarei M, Giudice L, Rosenfeld R. Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992;75:1046-53 pubmed
    ..Prostate-specific antigen (PSA) is a serine protease found in semen...
  9. Cicek M, Liu X, Casey G, Witte J. Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness. Cancer Epidemiol Biomarkers Prev. 2005;14:2173-7 pubmed
    ..androgen metabolism: CYP1B1 (two single nucleotide polymorphisms: 355G/T and 4326C/G), prostate-specific antigen (PSA/KLK3 (three single nucleotide polymorphisms: -158A/G, -4643G/A, and -5412C/T), and CYP11alpha [(tttta)(n) repeat], ..

More Information

Publications83

  1. Veveris Lowe T, Lawrence M, Collard R, Bui L, Herington A, Nicol D, et al. Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells. Endocr Relat Cancer. 2005;12:631-43 pubmed
    Prostate-specific antigen (PSA) and the related kallikrein family of serine proteases are current or emerging biomarkers for prostate cancer detection and progression...
  2. Lai J, Kedda M, Hinze K, Smith R, Yaxley J, Spurdle A, et al. PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility. Carcinogenesis. 2007;28:1032-9 pubmed
    The proximal promoter of the kallikrein-related peptidase 3 gene (KLK3/PSA) contains a single-nucleotide polymorphism (G-158A) located within the second canonical half-site for the prostate-specific antigen (PSA) androgen response ..
  3. Laidler P, Dulinska J, Lekka M, Lekki J. Expression of prostate specific membrane antigen in androgen-independent prostate cancer cell line PC-3. Arch Biochem Biophys. 2005;435:1-14 pubmed
    ..The values of interaction force between the same anti-PSMA antibodies and all studied cells were almost identical (45-64pN), indicating antigenic similarity of the membrane form of PSMA expressed in LNCaP, PC-3, and Du 145 cells. ..
  4. Pampalakis G, Scorilas A, Sotiropoulou G. Novel splice variants of prostate-specific antigen and applications in diagnosis of prostate cancer. Clin Biochem. 2008;41:591-7 pubmed publisher
    We aimed to identify novel splice variants of prostate-specific antigen/or human kallikrein 3 (PSA/KLK3), the most widely used serum biomarker for case-finding, screening and monitoring of prostate cancer...
  5. Cramer S, Chang B, Rao A, Hawkins G, Zheng S, Wade W, et al. Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels. J Natl Cancer Inst. 2003;95:1044-53 pubmed
    Recent evidence suggests that genetic variation in the promoter of the prostate-specific antigen (PSA) gene may contribute to individual variation in serum PSA levels...
  6. Paliouras M, Diamandis E. An AKT activity threshold regulates androgen-dependent and androgen-independent PSA expression in prostate cancer cell lines. Biol Chem. 2008;389:773-80 pubmed publisher
    ..itself in several forms, including a percentage of cancers that show reduced levels of prostate-specific antigen (PSA) and can progress without the need for the ligand or active receptor...
  7. Whitbread A, Veveris Lowe T, Dong Y, Tan O, Gardiner R, Samaratunga H, et al. Expression of PSA-RP2, an alternatively spliced variant from the PSA gene, is increased in prostate cancer tissues but the protein is not secreted from prostate cancer cells. Biol Chem. 2010;391:461-6 pubmed publisher
    b>PSA-RP2 is a variant transcript expressed from the PSA gene that is conserved in gorillas, chimpanzees and humans suggesting a particular relevance for this transcript in these primates...
  8. Heidtmann H, Nettelbeck D, Mingels A, Jager R, Welker H, Kontermann R. Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen. Br J Cancer. 1999;81:1269-73 pubmed
    ..It is generated from plasminogen by limited proteolysis. We show that prostate-specific antigen (PSA), a serine proteinase secreted by human prostate and human prostate cancer cells, is able to convert Lys-..
  9. Coombs G, Bergstrom R, Pellequer J, Baker S, Navre M, Smith M, et al. Substrate specificity of prostate-specific antigen (PSA). Chem Biol. 1998;5:475-88 pubmed
    The serine protease prostate-specific antigen (PSA) is a useful clinical marker for prostatic malignancy...
  10. Watt K, Lee P, M Timkulu T, Chan W, Loor R. Human prostate-specific antigen: structural and functional similarity with serine proteases. Proc Natl Acad Sci U S A. 1986;83:3166-70 pubmed
  11. Vickers A, Wolters T, Savage C, Cronin A, O Brien M, Pettersson K, et al. Prostate-specific antigen velocity for early detection of prostate cancer: result from a large, representative, population-based cohort. Eur Urol. 2009;56:753-60 pubmed publisher
    It has been suggested that changes in prostate-specific antigen (PSA) over time (ie, PSA velocity [PSAV]) aid prostate cancer detection. Some guidelines do incorporate PSAV cut points as an indication for biopsy...
  12. Eeles R, Kote Jarai Z, Giles G, Olama A, Guy M, Jugurnauth S, et al. Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet. 2008;40:316-21 pubmed publisher
    ..or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform...
  13. Pal P, Xi H, Sun G, Kaushal R, Meeks J, Thaxton C, et al. Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. Hum Genet. 2007;122:251-9 pubmed
    ..Four of the studied SNPs show positive associations with serum PSA levels...
  14. Klein R, Hallden C, Cronin A, Ploner A, Wiklund F, Bjartell A, et al. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. Cancer Prev Res (Phila). 2010;3:611-9 pubmed publisher
    ..of the prostate: KLK2 (encoding kallikrein-related peptidase 2; hK2), KLK3 (encoding prostate-specific antigen; PSA), and MSMB (encoding beta-microseminoprotein)...
  15. Christensson A, Laurell C, Lilja H. Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. Eur J Biochem. 1990;194:755-63 pubmed
    Prostate-specific antigen (PSA) is one of the three most abundant prostatic-secreted proteins in human semen...
  16. Severi G, Hayes V, Neufing P, Padilla E, Tilley W, Eggleton S, et al. Variants in the prostate-specific antigen (PSA) gene and prostate cancer risk, survival, and circulating PSA. Cancer Epidemiol Biomarkers Prev. 2006;15:1142-7 pubmed
    An A to G substitution, rs925013, in the promoter of the prostate-specific antigen gene (PSA) was recently found to be associated with promoter activity and circulating PSA levels...
  17. Beebe Dimmer J, Lange L, Cain J, Lewis R, Ray A, Sarma A, et al. Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men. Prostate Cancer Prostatic Dis. 2006;9:50-5 pubmed
    A major problem with the use of serum prostate-specific antigen (PSA) in predicting prostate cancer risk is the considerable variability of such measurements. Cramer et al...
  18. Sieh W, Edwards K, Fitzpatrick A, Srinouanprachanh S, Farin F, Monks S, et al. Genetic Susceptibility to Prostate Cancer: Prostate-specific Antigen and its Interaction with the Androgen Receptor (United States). Cancer Causes Control. 2006;17:187-97 pubmed
    To determine whether directly observed prostate-specific antigen (PSA) promoter diploid haplotype, either alone or in conjunction with androgen receptor (AR) genotype, is associated with prostate cancer risk...
  19. Binnie M, Alexander F, Heald C, Habib F. Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer. Prostate. 2005;63:309-15 pubmed
    Recent data has suggested that polymorphisms in the prostate specific antigen (PSA) may increase prostate cancer (PC) risk. The PSA gene contains a G/A substitution in the androgen response element (ARE) 1 region...
  20. Villoutreix B, Getzoff E, Griffin J. A structural model for the prostate disease marker, human prostate-specific antigen. Protein Sci. 1994;3:2033-44 pubmed
    Prostate-specific antigen (PSA) provides an excellent serum marker for prostate cancer, the most frequent form of cancer in American males. PSA is a 237-residue protease based on sequence homology to kallikrein-like enzymes...
  21. Denmeade S, Sokoll L, Chan D, Khan S, Isaacs J. Concentration of enzymatically active prostate-specific antigen (PSA) in the extracellular fluid of primary human prostate cancers and human prostate cancer xenograft models. Prostate. 2001;48:1-6 pubmed
    Prostate-specific antigen (PSA) targeted prodrugs are under development in our laboratory...
  22. Kader A, Sun J, Isaacs S, Wiley K, Yan G, Kim S, et al. Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients. Prostate. 2009;69:1195-205 pubmed publisher
    ..Since these SNPs are known to be associated with PSA levels in men without PCa diagnoses, these latter associations may reflect the enrichment of low grade, low stage ..
  23. Sutkowski D, Goode R, Baniel J, Teater C, Cohen P, McNulty A, et al. Growth regulation of prostatic stromal cells by prostate-specific antigen. J Natl Cancer Inst. 1999;91:1663-9 pubmed
    Prostate-specific antigen (PSA) is a serine protease that can cleave insulin-like growth factor-binding protein-3 (IGFBP3), thereby decreasing its affinity for insulin-like growth factor-I (IGF-I)...
  24. Parikh H, Deng Z, Yeager M, Boland J, Matthews C, Jia J, et al. A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33. Hum Genet. 2010;127:91-9 pubmed publisher
    ..33 are associated with serum prostate-specific antigen (PSA) levels...
  25. Medeiros R, Morais A, Vasconcelos A, Costa S, Pinto D, Oliveira J, et al. Linkage between polymorphisms in the prostate specific antigen ARE1 gene region, prostate cancer risk, and circulating tumor cells. Prostate. 2002;53:88-94 pubmed
    The prostate specific antigen (PSA) gene has a polymorphic androgen response element (ARE) sequence with two alleles, A and G. PSA A-allele carriers have higher serum PSA levels in healthy men (HM)...
  26. Xu J, Isaacs S, Sun J, Li G, Wiley K, Zhu Y, et al. Association of prostate cancer risk variants with clinicopathologic characteristics of the disease. Clin Cancer Res. 2008;14:5819-24 pubmed publisher
    ..aggressiveness, pathologic Gleason scores, pathologic stage, age at diagnosis, or serum prostate-specific antigen (PSA) levels were tested...
  27. Cramer S, Sun J, Zheng S, Xu J, Peehl D. Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:2451-7 pubmed publisher
    The serum test for the secreted protease prostate-specific antigen (PSA) is the most widely used screening tool for prostate cancer...
  28. Gsur A, Preyer M, Haidinger G, Zidek T, Madersbacher S, Schatzl G, et al. Polymorphic CAG repeats in the androgen receptor gene, prostate-specific antigen polymorphism and prostate cancer risk. Carcinogenesis. 2002;23:1647-51 pubmed
    ..by binding to androgen-response elements (AREs) in target genes, such as the prostate-specific antigen (PSA). In the ARE-I sequence of the PSA gene an adenine to guanine polymorphism is described...
  29. Chiang C, Chen K, Chang L, Hong C. The impact of polymorphism on prostate specific antigen gene on the risk, tumor volume and pathological stage of prostate cancer. J Urol. 2004;171:1529-32 pubmed
    ..guanine (G) substitution is identified at position -158 in the androgen response elements region of the prostate specific antigen (PSA) gene...
  30. Ishii K, Otsuka T, Iguchi K, Usui S, Yamamoto H, Sugimura Y, et al. Evidence that the prostate-specific antigen (PSA)/Zn2+ axis may play a role in human prostate cancer cell invasion. Cancer Lett. 2004;207:79-87 pubmed
    Prostate-specific antigen (PSA), which is used as a marker for the diagnosis and monitoring of prostate cancer, is a kallikrein protease which could potentially play a role in human prostate cancer cell invasion...
  31. Schatzl G, Marberger M, Remzi M, Grösser P, Unterlechner J, Haidinger G, et al. Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer. Urology. 2005;65:1141-5 pubmed
    To examine the impact of polymorphism in the androgen-responsive element I region of the prostate-specific antigen (PSA) gene on the serum testosterone level and Gleason score in patients with newly diagnosed, untreated prostate cancer (..
  32. Dallas S, Zhao S, Cramer S, Chen Z, Peehl D, Bonewald L. Preferential production of latent transforming growth factor beta-2 by primary prostatic epithelial cells and its activation by prostate-specific antigen. J Cell Physiol. 2005;202:361-70 pubmed
    ..We investigated whether prostate specific antigen (PSA), a serine protease used as a clinical marker for prostate cancer, could play a role in the ..
  33. Yeap B, Grossmann M, McLachlan R, Handelsman D, Wittert G, Conway A, et al. Endocrine Society of Australia position statement on male hypogonadism (part 2): treatment and therapeutic considerations. Med J Aust. 2016;205:228-31 pubmed
    ..Therapy should be monitored for efficacy and safety. ..
  34. Del Rosso A, Saldutto P, Di Pierro E, Masciovecchio S, Galatioto G, Vicentini C. [Impacts of antibiotic and anti-inflammatory therapy on serum prostate specific antigen in asymptomatic men: our experience]. Urologia. 2012;79 Suppl 19:37-40 pubmed publisher
    The management of "grey zone" elevated Prostate Specific Antigen (PSA) is uncertain. After prostate cancer, benign prostatic hyperplasia and prostatitis may induce PSA increase...
  35. Roobol M, Verbeek J, van der Kwast T, Kümmerlin I, Kweldam C, van Leenders G. Improving the Rotterdam European Randomized Study of Screening for Prostate Cancer Risk Calculator for Initial Prostate Biopsy by Incorporating the 2014 International Society of Urological Pathology Gleason Grading and Cribriform growth. Eur Urol. 2017;72:45-51 pubmed publisher
    ..We updated the RC3 using multinomial logistic regression analysis, including data on age, PSA, digital rectal examination, and prostate volume, for predicting LR and HR PCa...
  36. Li P, Merrill S, Jorgensen E, Shen K. Two Clathrin Adaptor Protein Complexes Instruct Axon-Dendrite Polarity. Neuron. 2016;90:564-80 pubmed publisher
    ..either the axon or the dendrite through direct interactions with the clathrin-associated adaptor protein complexes (APs) in C. elegans. Axonal targeting requires AP-3, while dendritic targeting is mediated by AP-1...
  37. Hruby G, Eade T, Kneebone A, Emmett L, Guo L, Ho B, et al. Delineating biochemical failure with 68Ga-PSMA-PET following definitive external beam radiation treatment for prostate cancer. Radiother Oncol. 2017;122:99-102 pubmed publisher
    ..the role of 68Ga-PSMA-PET (PSMA) to determine the location of disease recurrence in those with a rising PSA following definitive external beam radiation treatment (EBRT)...
  38. Maharaj A, Chandran V. Treatment of psoriatic arthritis with traditional DMARD's and novel therapies: approaches and recommendations. Expert Rev Clin Immunol. 2017;13:319-331 pubmed publisher
    Recent advances in the therapeutics of psoriatic arthritis (PsA) have provided more options to clinicians managing PsA...
  39. Fabre B, Grosman H, Gonzalez D, Machulsky N, Repetto E, Mesch V, et al. Prostate Cancer, High Cortisol Levels and Complex Hormonal Interaction. Asian Pac J Cancer Prev. 2016;17:3167-71 pubmed
    ..In this cross sectional study, cortisol, PSA, totaltestosterone, freetestosterone, bioavailable testosterone, LH and estradiol were measured in serum...
  40. Cui M, Tu C, Chen E, Wang X, Tan S, Chen C. A Cost-Effectiveness Analysis of Clopidogrel for Patients with Non-ST-Segment Elevation Acute Coronary Syndrome in China. Adv Ther. 2016;33:1600-11 pubmed publisher
    ..results, one-way sensitivity analyses were undertaken for key parameters, and probabilistic sensitivity analysis (PSA) was conducted using the Monte Carlo simulation...
  41. Bierkarre H, Harder J, Cuthbert R, Emery P, Leuschner I, Mrowietz U, et al. Differential expression of antimicrobial peptides in psoriasis and psoriatic arthritis as a novel contributory mechanism for skin and joint disease heterogeneity. Scand J Rheumatol. 2016;45:188-96 pubmed publisher
    ..antimicrobial peptide (AMP) profile was evident between the skin and joints in psoriasis and psoriatic arthritis (PsA) and that PsA synovitis may have a distinct AMP pattern compared to other arthropathies...
  42. Zhang J, Zhou J, Dai X, Liu G, Zhang S. Electrochemical preparation of two nanostructured poly(sulfosalicylic acid) films with different morphologies and properties for selective sensing of dopamine: Comparative study. Mater Sci Eng C Mater Biol Appl. 2017;77:151-158 pubmed publisher
    Two nanostructured poly(sulfosalicylic acid) (PSA) films were synthesized from room temperature ionic liquid (RTIL) or aqueous solution on a glassy carbon electrode (GCE) via potentiodynamic electropolymerization...
  43. Scholz G, Moller B. [Tapering and termination of immunosuppressive treatment in spondyloarthritides (including psoriatic arthritis)]. Z Rheumatol. 2017;76:21-26 pubmed publisher
    ..treatment has also become the standard treatment for spondyloarthritides (SpA), including psoriatic arthritis (PsA); however, uncertainty exists about dose reduction or termination of treatment after remission or low disease ..
  44. Lazzeri M, Lughezzani G, Haese A, McNicholas T, De La Taille A, Buffi N, et al. Clinical performance of prostate health index in men with tPSA>10ng/ml: Results from a multicentric European study. Urol Oncol. 2016;34:415.e13-9 pubmed publisher
    ..and diagnostic accuracy of PHI in determining the presence of PCa at biopsy in comparison to tPSA, free PSA, and % of free to total PSA...
  45. Touw H, Verheul M, Tuinman P, Smit J, Thöne D, Schober P, et al. Photoplethysmography respiratory rate monitoring in patients receiving procedural sedation and analgesia for upper gastrointestinal endoscopy. J Clin Monit Comput. 2017;31:747-754 pubmed publisher
    The value of capnography during procedural sedation and analgesia (PSA) for the detection of hypoxaemia during upper gastrointestinal (UGI) endoscopic procedures is limited...
  46. Lepore S, Wolf R, Basch C, Godfrey M, McGinty E, Shmukler C, et al. Informed decision making about prostate cancer testing in predominantly immigrant black men: a randomized controlled trial. Ann Behav Med. 2012;44:320-30 pubmed publisher
    ..There were no significant intervention effects on prostate specific antigen testing, congruence between testing intention and behavior, or anxiety...
  47. Bouraoui Y, Ben Jemaa A, Rodriguez G, Ben Rais N, Fraile B, Paniagua R, et al. Profile of NF-?Bp(65/NF?Bp50) among prostate specific antigen sera levels in prostatic pathologies. Pathol Biol (Paris). 2012;60:301-5 pubmed publisher
    ..of NF-?B (p50/p65) in human prostatic pathologies and to study its profiles of activation among sera prostate specific antigen antigen (PSA) according the three groups: 0-4ng/mL, 4-20ng/mL and >20ng/mL...
  48. Drummond F, O Leary E, Gavin A, Kinnear H, Sharp L. Mode of prostate cancer detection is associated with the psychological wellbeing of survivors: results from the PiCTure study. Support Care Cancer. 2016;24:2297-2307 pubmed publisher
    Many men with prostate cancer are asymptomatic, diagnosed following prostate specific antigen (PSA) testing. We investigate whether mode of detection, i.e...
  49. Lee J, Hong S, Yoon S, Kwon B, Ryu J, Giesy J, et al. Long-term changes in distributions of dioxin-like and estrogenic compounds in sediments of Lake Sihwa, Korea: Revisited mass balance. Chemosphere. 2017;181:767-777 pubmed publisher
    ..Target chemicals include polycyclic aromatic hydrocarbons (PAHs), alkylphenols (APs), and recently reported emerging chemicals, styrene oligomers (SOs)...
  50. Marchesoni A, De Marco G, Merashli M, McKenna F, Tinazzi I, Marzo Ortega H, et al. The problem in differentiation between psoriatic-related polyenthesitis and fibromyalgia. Rheumatology (Oxford). 2018;57:32-40 pubmed publisher
    ..and the prevalence of clinically occult enthesopathy in psoriatic subjects and of persistent joint pain in PsA subjects who have ostensibly good reduction of joint swelling under biological therapy has highlighted the ..
  51. Merrick G, Galbreath R, Bennett A, Butler W, Amamovich E. Incidence, grade and distribution of prostate cancer following transperineal template-guided mapping biopsy in patients with atypical small acinar proliferation. World J Urol. 2017;35:1009-1013 pubmed publisher
    ..The mean patient age was 63.8 years with a mean PSA of 6.8 ng/mL. Of the 132 patients, 86 (65.2%) were diagnosed with prostate cancer...
  52. El Hawari K, Mokh S, Doumyati S, Al Iskandarani M, Verdon E. Development and validation of a multiclass method for the determination of antibiotic residues in honey using liquid chromatography-tandem mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017;34:582-597 pubmed publisher
    ..10 min of ultrasonic treatment with acidified methanol (HCl 2 M) followed by dispersive SPE clean-up with 50 mg PSA gave an effective sample preparation method for several classes of antibiotics in honey...
  53. Reig Ã, Marín Aguilera M, Carrera G, Jiménez N, Paré L, García Recio S, et al. TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer. Eur Urol. 2016;70:709-713 pubmed publisher
    ..In docetaxel-treated patients TMPRSS2-ERG detection correlated with lower prostatic-specific antigen (PSA) response rate (12.5% vs 68.3%, p=0.005), PSA-progression-free survival (PFS; 3.1 mo vs 7.5 mo, p<0...
  54. Kong X, Qian X, Duan L, Liu H, Zhu Y, Qi J. microRNA-372 Suppresses Migration and Invasion by Targeting p65 in Human Prostate Cancer Cells. DNA Cell Biol. 2016;35:828-835 pubmed
    ..Taken together, our results show evidence that miR-372 may function as a tumor suppressor gene by regulating p65 in PCa and may provide a strategy for blocking PCa metastasis. ..
  55. Sävblom C, Hallden C, Cronin A, Sall T, Savage C, Vertosick E, et al. Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men. Clin Chem. 2014;60:490-9 pubmed publisher
    ..concentrations of their encoded proteins, human kallikrein-related peptidase 2 (hK2) and prostate-specific antigen (PSA), and with prostate cancer in older men...
  56. Campion M. Paul W. Thayer (1927-2017). Am Psychol. 2017;72:713 pubmed publisher
    ..He was a fellow of the American Psychological Association (APA), American Psychological Society (APS), and Society for Industrial and Organizational Psychology (SIOP)...
  57. Ubrig B, Merklinghaus A, Heiland M, Roosen A. Outcome of Robotic Radical Prostatectomy in Men over 74. J Endourol. 2017;: pubmed publisher
    ..Material and Methods 647 patients over 74 patients?75 were analyzed for preoperative factors (BMI,ASA,PSA,IPSS,IIEF), operative and perioperative characteristics (technique,erythrocyte conc...
  58. Salami S, Schmidt F, Laxman B, Regan M, Rickman D, Scherr D, et al. Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer. Urol Oncol. 2013;31:566-71 pubmed publisher
    We sought to develop a clinical algorithm combining serum PSA with detection of TMPRSS2:ERG fusion and PCA3 in urine collected after digital rectal exam (post-DRE urine) to predict prostate cancer on subsequent biopsy...
  59. Marchesoni A, Olivieri I, Salvarani C, Pipitone N, D Angelo S, Mathieu A, et al. Recommendations for the use of biologics and other novel drugs in the treatment of psoriatic arthritis: 2017 update from the Italian Society of Rheumatology. Clin Exp Rheumatol. 2017;35:991-1010 pubmed
    ..SIR) recommendations for the use of biologics and other novel agents in the treatment of psoriatic arthritis (PsA). To create this new set of recommendations, the SIR "Spondyloartritis and Psoriatic Arthritis study group - A...
  60. Patel P, Rosen C, Chandran V, Ye Y, Gladman D. Addressing comorbidities in psoriatic disease. Rheumatol Int. 2018;38:219-227 pubmed publisher
    Psoriasis and PsA are associated with comorbidities including cardiovascular disease, obesity, metabolic syndrome and depression...
  61. Acosta A, Al Rasheed M, Rauscher G, Vormittag E, Mon K, Sharif A, et al. Tumor necrosis in radical prostatectomies with high-grade prostate cancer is associated with multiple poor prognostic features and a high prevalence of residual disease. Hum Pathol. 2018;75:1-9 pubmed publisher
    ..0001). Our results show that GP5 with tumor necrosis is associated with poor prognostic histopathologic features and high rates of residual disease after prostatectomy. ..
  62. Chronaiou I, Thomsen R, Huuse E, Euceda L, Pedersen S, Hoff M, et al. Quantifying bone marrow inflammatory edema in the spine and sacroiliac joints with thresholding. BMC Musculoskelet Disord. 2017;18:497 pubmed publisher
    Psoriatic Arthritis (PsA) is a chronic inflammatory arthritis that develops in patients with psoriasis. Inflammatory edema in the spine may reflect subclinical disease activity and be a predictor of radiographic progression...
  63. Jing Y, Nguyen M, Wang D, Pascal L, Guo W, Xu Y, et al. DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor. Oncogene. 2017;: pubmed publisher
    ..Collectively, our data argue that DHX15 enhances AR transcriptional activity and contributes to PCa progression through Siah2.Oncogene advance online publication, 9 October 2017; doi:10.1038/onc.2017.371...
  64. Willis R, Papalardo E, Nigel Harris E. Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies. Methods Mol Biol. 2017;1646:185-199 pubmed publisher
    ..assay for identifying patients with a disorder that came to be later known as the antiphospholipid syndrome (APS)...
  65. Safdieh J, Schwartz D, Rineer J, Weiner J, Wong A, Schreiber D. Does the Presence of a Major Psychiatric Disorder Affect Tolerance and Outcomes in Men With Prostate Cancer Receiving Radiation Therapy?. Am J Mens Health. 2015;: pubmed
    ..The presence of +Psy was not associated with higher toxicity or worse clinical outcomes, suggesting that effective removal of screening and treatment barriers may reduce the survival disparities of these patients. ..
  66. Heidegger I, Klocker H, Pichler R, Horninger W, Bektic J. PSA Isoforms' Velocities for Early Diagnosis of Prostate Cancer. Anticancer Res. 2015;35:3567-70 pubmed
    Free prostate-specific antigen (fPSA) and its molecular isoforms are suggested for enhancement of PSA testing in prostate cancer (PCa)...
  67. Chuu C, Chen R, Kokontis J, Hiipakka R, Liao S. Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells. Cancer Lett. 2009;275:86-92 pubmed publisher
    ..EGCG suppressed cell proliferation, prostate specific antigen (PSA) expression, and AR transcriptional activity in the different LNCaP sublines...
  68. Koprivova A, Kopriva S. Sulfation pathways in plants. Chem Biol Interact. 2016;259:23-30 pubmed publisher
    Plants take up sulfur in the form of sulfate. Sulfate is activated to adenosine 5'-phosphosulfate (APS) and reduced to sulfite and then to sulfide when it is assimilated into amino acid cysteine...
  69. Wei C, Callahan B, Turner M, Willis R, Lord E, Barth R, et al. Regulation of human prostate-specific antigen gene expression in transgenic mice: evidence for an enhancer between the PSA and human glandular kallikrein-1 genes. Int J Mol Med. 1998;2:487-96 pubmed
    The human prostate-specific antigen (PSA) and glandular kallikrein-1 (hGK-1, also known as hK2) genes are tandemly located on chromosome 19, separated by a 12-kb intergenic region...
  70. Scott A, Garimella V, Calabrese C, Mirkin C. Universal Biotin-PEG-Linked Gold Nanoparticle Probes for the Simultaneous Detection of Nucleic Acids and Proteins. Bioconjug Chem. 2017;28:203-211 pubmed publisher
    ..have been synthesized and used as universal constructs for the detection of protein (prostate-specific antigen, PSA) and nucleic acid targets (microRNAs) from a single sample...
  71. Miarons M, Cabib C, Barón F, Rofes L. Evidence and decision algorithm for the withdrawal of antipsychotic treatment in the elderly with dementia and neuropsychiatric symptoms. Eur J Clin Pharmacol. 2017;73:1389-1398 pubmed publisher
    Antipsychotics (APs) are commonly used to manage neuropsychiatric symptoms (NPS) in elderly patients with dementia, even though several large studies have demonstrated an association between AP treatment and increased morbidity and ..
  72. Kupinski M, Bankhead J, Stohn A, Chipman R. Binary classification of Mueller matrix images from an optimization of Poincaré coordinates. J Opt Soc Am A Opt Image Sci Vis. 2017;34:983-990 pubmed publisher
    ..classification method for Mueller matrix images is presented which optimizes the polarization state analyzer (PSA) and the polarization state generator (PSG) using a statistical divergence between pixel values in two regions of ..
  73. Nader R, El Amm J, Aragon Ching J. Role of chemotherapy in prostate cancer. Asian J Androl. 2017;: pubmed publisher
    ..The improvement in overall survival as well as secondary endpoints of prostate-specific antigen (PSA) and time to recurrence when using docetaxel in the metastatic hormone-sensitive state has changed the standard of ..
  74. Magklara A, Brown T, Diamandis E. Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3. Int J Cancer. 2002;100:507-14 pubmed
    ..We examined previously the steroid hormone regulation of 2 known androgen-regulated kallikreins, KLK3 (encoding PSA) and KLK2 (encoding human kallikrein 2 or hK2) in BT-474, T-47D, ZR75-1, MCF-7, MFM-223 and BT-20 human breast ..