prostaglandin E synthase

Summary

Gene Symbol: prostaglandin E synthase
Description: prostaglandin E synthase
Alias: MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1, prostaglandin E synthase, MGST1-like 1, glutathione S-transferase 1-like 1, microsomal glutathione S-transferase 1-like 1, microsomal prostaglandin E synthase-1, p53-induced apoptosis protein 12, p53-induced gene 12 protein, tumor protein p53 inducible protein 12
Species: human
Products:     prostaglandin E synthase

Top Publications

  1. Forsberg L, Leeb L, Thorén S, Morgenstern R, Jakobsson P. Human glutathione dependent prostaglandin E synthase: gene structure and regulation. FEBS Lett. 2000;471:78-82 pubmed
    A P1 clone containing the gene for human glutathione dependent PGE synthase (PGES) was isolated and characterized. The gene is divided into three exons, spans 14.8 kb and was localized to chromosome 9q34. 3...
  2. Hanaka H, Pawelzik S, Johnsen J, Rakonjac M, Terawaki K, Rasmuson A, et al. Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells. Proc Natl Acad Sci U S A. 2009;106:18757-62 pubmed publisher
    ..COX-1/COX-2) convert arachidonic acid to PGH(2), which can be isomerized to PGE(2) by microsomal PGE-synthase-1 (MPGES-1). The human prostate cancer cell line DU145 expressed high amounts of MPGES-1 in a constitutive manner...
  3. Kamei D, Murakami M, Nakatani Y, Ishikawa Y, Ishii T, Kudo I. Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J Biol Chem. 2003;278:19396-405 pubmed
    Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase (COX)-2 in the PGE2-biosynthetic pathway...
  4. Trebino C, Stock J, Gibbons C, Naiman B, Wachtmann T, Umland J, et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A. 2003;100:9044-9 pubmed
    ..These findings suggest that mPGES1 provides a target for the treatment of inflammatory diseases and pain associated with inflammatory states. ..
  5. Westman M, Korotkova M, af Klint E, Stark A, Audoly L, Klareskog L, et al. Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium. Arthritis Rheum. 2004;50:1774-80 pubmed
    b>Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the formation of PGE(2) from cyclooxygenase-derived PGH(2)...
  6. Takii Y, Abiru S, Fujioka H, Nakamura M, Komori A, Ito M, et al. Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma. Liver Int. 2007;27:989-96 pubmed
    The objective of this study was to evaluate the expression of microsomal prostaglandin E synthase-1 (mPGES-1) in hepatocellular carcinoma (HCC) tissues...
  7. Jegerschöld C, Pawelzik S, Purhonen P, Bhakat P, Gheorghe K, Gyobu N, et al. Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proc Natl Acad Sci U S A. 2008;105:11110-5 pubmed publisher
    ..b>Microsomal prostaglandin E synthase 1 (MPGES1) constitutes an inducible glutathione-dependent integral membrane protein that catalyzes ..
  8. Chabane N, Li X, Fahmi H. HDAC4 contributes to IL-1-induced mPGES-1 expression in human synovial fibroblasts through up-regulation of Egr-1 transcriptional activity. J Cell Biochem. 2009;106:453-63 pubmed publisher
    Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE(2), which contributes to many physiopathological processes...
  9. Casós K, Siguero L, Fernandez Figueras M, Leon X, Sardà M, Vila L, et al. Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation. Microvasc Res. 2011;81:261-8 pubmed publisher
    ..cells do not produce PGE(2) enzymatically because they do not express the inducible microsomal PGE-synthase-1 (mPGES-1)...

More Information

Publications118 found, 100 shown here

  1. Lu D, Han C, Wu T. Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/?-catenin signaling axis. Oncogene. 2012;31:842-57 pubmed publisher
    Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that couples with cyclooxygenase-2 (COX-2) for the production of PGE(2)...
  2. Jakobsson P, Thorén S, Morgenstern R, Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A. 1999;96:7220-5 pubmed
    ..Previous designations of the protein are PIG12 and MGST1-L1...
  3. Thorén S, Weinander R, Saha S, Jegerschöld C, Pettersson P, Samuelsson B, et al. Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem. 2003;278:22199-209 pubmed
    Human, microsomal, and glutathione-dependent prostaglandin (PG) E synthase-1 (mPGES-1) was expressed with a histidine tag in Escherichia coli...
  4. Subbaramaiah K, Yoshimatsu K, Scherl E, Das K, Glazier K, Golijanin D, et al. Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. J Biol Chem. 2004;279:12647-58 pubmed
    Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the conversion of cyclooxygenase-derived prostaglandin (PG) H(2) to PGE(2)...
  5. Camacho M, Dilmé J, Solà Villà D, Rodriguez C, Bellmunt S, Siguero L, et al. Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm. J Lipid Res. 2013;54:3506-15 pubmed publisher
    ..Like endothelial cell markers, cyclooxygenase (COX)-2 and the microsomal isoform of prostaglandin E synthase (mPGES-1) transcripts were increased in AAA (4.4- and 1.4-fold, respectively)...
  6. Gargouri B, Yousif N, Bouchard M, Fetoui H, Fiebich B. Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures. J Neuroinflammation. 2018;15:159 pubmed publisher
    ..interleukin-6 (IL-6), nuclear erythroid-2 like factor-2 (Nrf-2), and microsomal prostaglandin synthase-1 (mPGES-1) was also studied by qPCR and Western blot...
  7. Cong R, Tao K, Fu P, Lou L, Zhu Y, Chen S, et al. MicroRNA?218 promotes prostaglandin E2 to inhibit osteogenic differentiation in synovial mesenchymal stem cells by targeting 15?hydroxyprostaglandin dehydrogenase [NAD(+)]. Mol Med Rep. 2017;16:9347-9354 pubmed publisher
    ..a significant association between miR?128, 15?HPGD gene expression, 15?HPGD protein expression and microsomal prostaglandin E synthase 1. Further experiments demonstrated that miR?218 decreased PGE2 concentration by binding to the 3'?..
  8. Holen E, Araujo P, Sissener N, Rosenlund G, Waagbø R. A comparative study: Difference in omega-6/omega-3 balance and saturated fat in diets for Atlantic salmon (Salmo salar) affect immune-, fat metabolism-, oxidative and apoptotic-gene expression, and eicosanoid secretion in head kidney leukocytes. Fish Shellfish Immunol. 2018;72:57-68 pubmed publisher
    ..In addition, equal amounts of LPS induced PGE2 and PGE3 (mean 0, 5 ng/mL) were produced, indicating that the n-6/n-3 ratio of this saturated fatty acid may have a specific impact on eicosanoid production in the head kidney of salmon. ..
  9. Li S, Sun X, He Y, Guo Y, Zhao H, Hou Z, et al. Assessment of arsenic trioxide in the heart of Gallus gallus: alterations of oxidative damage parameters, inflammatory cytokines, and cardiac enzymes. Environ Sci Pollut Res Int. 2017;24:5781-5790 pubmed publisher
    ..nuclear factor-kappa B (NF-?B), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and prostaglandin E synthase (PTGEs)) significantly increased (P < 0...
  10. Korzekwa A, Bodek G, Bukowska J, Blitek A, Skarzynski D. Characterization of bovine immortalized luteal endothelial cells: action of cytokines on production and content of arachidonic acid metabolites. Reprod Biol Endocrinol. 2011;9:27 pubmed publisher
    ..Cytokines had no effect on PGES and LTA4H protein expression, and PGE2 and LTB4 release. TNFalpha and IFNgamma modulate EnCL-1 cell function...
  11. Sun X, Li J, Zhao H, Wang Y, Liu J, Shao Y, et al. Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus. J Inorg Biochem. 2018;178:54-62 pubmed publisher
    ..such as nuclear factor kappa B (NF-?B), tumor necrosis factor-? (TNF-?), cyclooxygenase-2 (COX-2) and prostaglandin E synthase (PTGEs) were significantly increased (P<0.05)...
  12. Zhang Z, Bi M, Yao H, Fu J, Li S, Xu S. Effect of cold stress on expression of AMPKalpha-PPARalpha pathway and inflammation genes. Avian Dis. 2014;58:415-26 pubmed
    ..carnitine palmitoyltransferaseI [CPTI], acetyl-CoA carboxylase [ACC]) and inflammatory cytokines (prostaglandin E synthase [PGEs], inducible nitric oxide synthase [iNOS], heme oxygenase-1 [HO-1], nuclear factor kappa-light-chain-..
  13. Gargouri B, Bhatia H, Bouchard M, Fiebich B, Fetoui H. Inflammatory and oxidative mechanisms potentiate bifenthrin-induced neurological alterations and anxiety-like behavior in adult rats. Toxicol Lett. 2018;294:73-86 pubmed publisher
    ..and mRNA expression of the inflammatory mediators cyclooxygenase-2 (COX-2), microsomal prostaglandin synthase-1 (mPGES-1) and nuclear factor-kappaBp65 (NF-kBp65), as well as the production of tumor necrosis factor-? (TNF-?) and ROS...
  14. Carceller M, Guillén M, Ferrándiz M, Alcaraz M. Paracrine in vivo inhibitory effects of adipose tissue-derived mesenchymal stromal cells in the early stages of the acute inflammatory response. Cytotherapy. 2015;17:1230-9 pubmed publisher
    ..In addition, the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 (mPGES-1) was studied by use of Western blotting and the phosphorylation of p65 nuclear factor-κB (..
  15. Lima F, Greco L, Bisinotto R, Ribeiro E, Martínez N, Thatcher W, et al. Effects of intrauterine infusion of Trueperella pyogenes on endometrial mRNA expression of proinflammatory cytokines and luteolytic cascade genes and their association with luteal life span in dairy cows. Theriogenology. 2015;84:1263-72 pubmed publisher
    ..evaluate the endometrial messenger RNA expression of TNFα (TNF), interleukin-1β (IL1B), IL6, IL8, prostaglandin E synthase (PGES), prostaglandin F synthase (PGFS), and oxytocin receptor (OXR), and histologic evidence of ..
  16. Li S, Guo Y, He Y, Sun X, Zhao H, Wang Y, et al. Assessment of arsenic trioxide toxicity on cock muscular tissue: alterations of oxidative damage parameters, inflammatory cytokines and heat shock proteins. Ecotoxicology. 2017;26:1078-1088 pubmed publisher
    ..factor-? (TNF-?), nuclear factor-kappa B (NF-?B), cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS), prostaglandin E synthase (PTGEs)) and heat shock proteins (HSPs) in muscular tissue were significantly upregulated in the As2<..
  17. Bhatia H, Baron J, Hagl S, Eckert G, Fiebich B. Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway. J Neuroinflammation. 2016;13:148 pubmed publisher
    ..Protein levels and genes related to PGE2 synthesis (Cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1)) and various pro- and anti-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-10), were ..
  18. Guo B, Tian X, Li D, Yang Z, Cao H, Zhang Q, et al. Expression, regulation and function of Egr1 during implantation and decidualization in mice. Cell Cycle. 2014;13:2626-40 pubmed publisher
    ..found that Egr1 played a role through influencing the expression of cyclooxygenase-2 (Cox-2), microsomal prostaglandin E synthase 1 (mPGES-1), vascular endothelial growth factor (Vegf), transformation related protein 53 (Trp53) ..
  19. Hosono K, Isonaka R, Kawakami T, Narumiya S, Majima M. Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice. PLoS ONE. 2016;11:e0162532 pubmed publisher
    ..in mouse ears, and this increase was accompanied by increased expression levels of COX-2 and microsomal prostaglandin E synthase-1...
  20. Choi Y, Wilson K, Hannon P, Rosewell K, Brannstrom M, Akin J, et al. Coordinated Regulation Among Progesterone, Prostaglandins, and EGF-Like Factors in Human Ovulatory Follicles. J Clin Endocrinol Metab. 2017;102:1971-1982 pubmed publisher
    ..In vitro studies indicated that collaborative actions of P4/PGR and EGF signaling are required for hCG-induced increases in PTG production and potentiation of EGF signaling in human periovulatory granulosa cells. ..
  21. Ren J, Liu C, Zhao D, Fu J. The role of heat shock protein 70 in oxidant stress and inflammatory injury in quail spleen induced by cold stress. Environ Sci Pollut Res Int. 2018;25:21011-21023 pubmed publisher
    ..Additionally, the inflammatory factors (cyclooxygenase-2 (COX-2), prostaglandin E synthase (PTGES), iNOS, nuclear factor-kappa B (NF-κB), and tumor necrosis factor-a (TNF-α)) and Hsp70 mRNA ..
  22. Gargouri B, Yousif N, Attaai A, Bouchard M, Chtourou Y, Fiebich B, et al. Pyrethroid bifenthrin induces oxidative stress, neuroinflammation, and neuronal damage, associated with cognitive and memory impairment in murine hippocampus. Neurochem Int. 2018;120:121-133 pubmed publisher
    ..further resulted in a significant increase in protein levels of Nrf2, COX-2, microsomal prostaglandin synthase-1 (mPGES-1) and NF-kappaB...
  23. Liu J, Tang J, Zuo Y, Yu Y, Luo P, Yao X, et al. Stauntoside B inhibits macrophage activation by inhibiting NF-κB and ERK MAPK signalling. Pharmacol Res. 2016;111:303-315 pubmed publisher
    ..including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), microsomal prostaglandin synthetase-1 (mPGES-1), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and monocyte ..
  24. Fan R, Yao H, Cao C, Zhao X, Khalid A, Zhao J, et al. Gene Silencing of Selenoprotein K Induces Inflammatory Response and Activates Heat Shock Proteins Expression in Chicken Myoblasts. Biol Trace Elem Res. 2017;180:135-145 pubmed publisher
    ..synthase [iNOS], nuclear factor-kappa B [NF-?B], heme-oxygenase-1 [HO-1], cyclooxygenase-2 [COX-2], and prostaglandin E synthase [PTGEs]), inflammation-related cytokines (including interleukin [IL]-1?, IL-6, IL-7, IL-8, IL-17, and ..
  25. Dirandeh E, Towhidi A, Pirsaraei Z, Saberifar T, Akhlaghi A, Roodbari A. The endometrial expression of prostaglandin cascade components in lactating dairy cows fed different polyunsaturated fatty acids. Theriogenology. 2015;83:206-12 pubmed publisher
    ..to evaluate the expression of genes related to prostaglandin cascade (prostaglandin F synthase [PGFS], prostaglandin E synthase [PGES], prostaglandin endoperoxide synthase-2 [PGHS-2]), phospholipase A2 (PLA2), peroxisome proliferator-..
  26. Rebordão M, Galvão A, Pinto Bravo P, Pinheiro J, Gamboa S, Silva E, et al. Endometrial prostaglandin synthases, ovarian steroids, and oxytocin receptors in mares with oxytocin-induced luteal maintenance. Theriogenology. 2017;87:193-204 pubmed publisher
    ..This study offers new knowledge on the endometrial expression of ovarian steroids and OXT receptors in OXT pharmacologically induced luteal maintenance in the mare. ..
  27. Yoshimoto A, Kasahara K, Kawashima A, Fujimura M, Nakao S. Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. Oncol Rep. 2005;13:1049-57 pubmed
    ..of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were examined for autopsied cases with small cell lung cancer (..
  28. Lim S, Cho H, Lee T, Choi C, Min Y, Kim S, et al. Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer. Yonsei Med J. 2010;51:692-9 pubmed publisher
    ..E2 synthesis, other enzymes such as cytosolic phospholipase A2 (cPLA2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH) have been suggested to be related to carcinogenesis of colorectal ..
  29. Saroj Devi N, Shanmugam R, Ghorai J, Ramanan M, Anbarasan P, Doble M. Ligand-based Modeling for the Prediction of Pharmacophore Features for Multi-targeted Inhibition of the Arachidonic Acid Cascade. Mol Inform. 2017;: pubmed publisher
    ..common to the inhibitors of 5-lipoxygenase-activating protein (FLAP), microsomal prostaglandin E-synthase 1 (mPGES-1) and leukotriene A4 hydrolase (LTA4H)...
  30. Altan B, Kaira K, Watanabe A, Kubo N, Bao P, Dolgormaa G, et al. Relationship between LAT1 expression and resistance to chemotherapy in pancreatic ductal adenocarcinoma. Cancer Chemother Pharmacol. 2018;81:141-153 pubmed publisher
    ..LAT1 as an independent prognostic marker is a potential molecular targeting gene to reduce chemoresistance and tumor growth in patients with PDAC, supported by our in vitro study. ..
  31. Revathikumar P, Estelius J, Karmakar U, Le Maitre E, Korotkova M, Jakobsson P, et al. Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen. PLoS ONE. 2018;13:e0193210 pubmed publisher
    ..immunosuppression in response to LPS associated inflammation is impaired in mice lacking microsomal prostaglandin E synthase-1 (mPGES-1) expression, a key enzyme responsible for prostaglandin E2 synthesis...
  32. Ishii Y, Sasaki T, Serikawa M, Minami T, Okazaki A, Yukutake M, et al. Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: ?mplications for cholangiocarcinogenesis. Int J Oncol. 2013;43:1073-9 pubmed publisher
    ..Cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) induced by inflammation are believed to mediate prostaglandin E2 (PGE2) production thereby ..
  33. Guo Y, Lei W, Wang J, Hu X, Wei Y, Ji C, et al. Misoprostol Reverse Hippocampal Neuron Cyclooxygenase-2 Downstream Signaling Imbalance in Aluminum-Overload Rats. Curr Alzheimer Res. 2016;13:1006-16 pubmed
    ..Meanwhile, the administration of misoprostol resulted in a decrease in the PGE2 level and down-regulation of the mPGES-1, EP2 and EP4 expression levels, while there was a dosedependent up-regulation of EP3 expression...
  34. Wang X, Shaw D, Hammond H, Sutterwala F, Rayamajhi M, Shirey K, et al. The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog. 2016;12:e1005803 pubmed publisher
    ..to the eicosanoid prostaglandin E2 (PGE2) via cyclooxygenase 2 (COX2) and the membrane associated prostaglandin E synthase-1 (mPGES-1)...
  35. Eren D, Betul Y. Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3? and ?-catenin pathway in A549 cell line. Chem Biol Interact. 2016;258:257-65 pubmed publisher
    ..We aimed to reveal their effects on microsomal prostaglandine E2 synthase 1 (mPGES-1) which is related with cancer progression and inflammation as well as ?-catenin and glycogen synthase kinase 3? (..
  36. Uzunboy S, Cekiç S, Eksin E, Erdem A, Apak R. CUPRAC colorimetric and electroanalytical methods determining antioxidant activity based on prevention of oxidative DNA damage. Anal Biochem. 2017;518:69-77 pubmed publisher
    ..Additionally, the DNA damage was electrochemically investigated using pencil graphite electrodes (PGEs) as DNA sensor platform in combination with differential pulse voltammetry (DPV)...
  37. Khan H, Rengasamy K, Pervaiz A, Nabavi S, Atanasov A, Kamal M. Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation. Eur J Med Chem. 2018;153:2-28 pubmed publisher
    ..The aim of this review is to summarize the described microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors or transcriptional suppressors from medicinal plants, which could be an ideal ..
  38. Ríos F, Fernández Arteaga A, Lechuga M, Fernández Serrano M. Ecotoxicological characterization of polyoxyethylene glycerol ester non-ionic surfactants and their mixtures with anionic and non-ionic surfactants. Environ Sci Pollut Res Int. 2017;24:10121-10130 pubmed publisher
    ..Toxicity of pure PGEs was determined using representative organisms from different trophic levels: luminescent bacteria (Vibrio fischeri),..
  39. He G, Luo Z, Shen T, Li P, Yang J, Luo X, et al. Inhibition of STAT3- and MAPK-dependent PGE2 synthesis ameliorates phagocytosis of fibrillar β-amyloid peptide (1-42) via EP2 receptor in EMF-stimulated N9 microglial cells. J Neuroinflammation. 2016;13:296 pubmed
    ..microglia were investigated based on the expressions of JAK2, STAT3, p38/ERK/JNK MAPKs, COX-2, microsomal prostaglandin E synthase-1 (mPGES-1), and EP2 using real-time PCR and/or western blotting...
  40. Saridi M, Kapogeorgou E, Rekleiti M, Geitona M, Souliotis K. Knowledge and attitudes of women regarding gynaecological cancer prevention in an urban area of Greece in financial crisis. Scand J Caring Sci. 2017;31:710-717 pubmed publisher
    Preventive gynaecological examinations (PGEs) are the main means of monitoring gynaecological cancers across the developed world...
  41. Gokuldas P, Singh S, Tamuli M, Naskar S, Vashi Y, Thomas R, et al. Dietary supplementation of n-3 polyunsaturated fatty acid alters endometrial expression of genes involved in prostaglandin biosynthetic pathway in breeding sows (Sus scrofa). Theriogenology. 2018;110:201-208 pubmed publisher
    ..Prostaglandin F Synthase (PGFS), microsomal Prostaglandin E Synthase-1 (mPGES-1) and Carbonyl Reductase-1 (CBR-1) using quantitative Real-Time PCR...
  42. Le Mee S, Hennebert O, Ferrec C, Wulfert E, Morfin R. 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. Steroids. 2008;73:1148-59 pubmed publisher
  43. Hammarberg T, Hamberg M, Wetterholm A, Hansson H, Samuelsson B, Haeggstrom J. Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha. J Biol Chem. 2009;284:301-5 pubmed publisher
    Microsomal prostaglandin E synthase type 1 (mPGES-1) converts prostaglandin endoperoxides, generated from arachidonic acid by cyclooxygenases, into prostaglandin E2...
  44. Xu J, Jin B, Yan J, Wang J, Hu J, Wang Z, et al. Postictal generalized EEG suppression after generalized convulsive seizures: A double-edged sword. Clin Neurophysiol. 2016;127:2078-84 pubmed publisher
    The aim of this study is to investigate the key facilitating factors for postictal generalized EEG suppression (PGES) in a large cohort of patients with generalized convulsive seizures (GCSs)...
  45. De Marco P, Lappano R, De Francesco E, Cirillo F, Pupo M, Avino S, et al. GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1?/IL1R1 response. Sci Rep. 2016;6:24354 pubmed publisher
    ..A better understanding of the mechanisms involved in the regulation of pro-inflammatory cytokines by GPER-integrated estrogen signals may be useful to target these stroma-cancer interactions. ..
  46. Tuure L, Hamalainen M, Moilanen E. PDE4 inhibitor rolipram inhibits the expression of microsomal prostaglandin E synthase-1 by a mechanism dependent on MAP kinase phosphatase-1. Pharmacol Res Perspect. 2017;5: pubmed publisher
    ..Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme synthesizing PGE2 , the most abundant prostanoid related to ..
  47. Finetti F, Terzuoli E, Giachetti A, Santi R, Villari D, Hanaka H, et al. mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity. Endocr Relat Cancer. 2015;22:665-78 pubmed publisher
    ..Here we investigated whether expression of intrinsic microsomal PGE synthase-1 (mPGES-1) enhanced aggressiveness of PCa cells and might be critical for epidermal growth factor receptor (EGFR)-mediated ..
  48. Wu C, Xu Z, Huang K. Effects of Dietary Selenium on Inflammation and Hydrogen Sulfide in the Gastrointestinal Tract in Chickens. Biol Trace Elem Res. 2016;174:428-435 pubmed
    ..The downregulation exacerbates the inflammation and impacts H2S-mediated intestinal functions. ..
  49. Ramanan M, Doble M. Transcriptional Regulation of mPGES1 in Cancer: An Alternative Approach to Drug Discovery?. Curr Drug Targets. 2017;18:119-131 pubmed
    ..These novel compounds that are inhibitors of the major transcription factors are promising candidates for further development as inhibitors of mPGES1. ..
  50. Koeberle A, Werz O. Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis. Biotechnol Adv. 2018;36:1709-1723 pubmed publisher
    ..This concept led to dual inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase that are crucial enzymes in the biosynthesis of pro-inflammatory prostaglandin E2 ..
  51. Partridge K, Antonysamy S, Bhattachar S, Chandrasekhar S, Fisher M, Fretland A, et al. Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1. Bioorg Med Chem Lett. 2017;27:1478-1483 pubmed publisher
    We describe a novel class of acidic mPGES-1 inhibitors with nanomolar enzymatic and human whole blood (HWB) potency...
  52. Qasem H, Al Ayadhi L, Bjørklund G, Chirumbolo S, El Ansary A. Impaired lipid metabolism markers to assess the risk of neuroinflammation in autism spectrum disorder. Metab Brain Dis. 2018;33:1141-1153 pubmed publisher
    ..to test the possible association between prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1), prostaglandin PGE2 EP2 receptors and nuclear kappa B (NF-κB) and the severity of cognitive ..
  53. Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, et al. Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury. Arterioscler Thromb Vasc Biol. 2018;38:1115-1124 pubmed publisher
    Deletion of mPGES-1 (microsomal prostaglandin E synthase-1)-an anti-inflammatory target alternative to COX (cyclooxygenase)-2-attenuates injury-induced neointima formation in mice...
  54. Dilmé J, Solà Villà D, Bellmunt S, Romero J, Escudero J, Camacho M, et al. Active smoking increases microsomal PGE2-synthase-1/PGE-receptor-4 axis in human abdominal aortic aneurysms. Mediators Inflamm. 2014;2014:316150 pubmed publisher
    The cyclooxygenase- (COX-) 2/microsomal PGE-synthase- (mPGES-) 1/PGE-receptor- (EP-) 4 axis could play a key role in the physiopathology of abdominal aortic aneurysm (AAA) in humans...
  55. Marentette J, Hurst R, McHowat J. Impaired Expression of Prostaglandin E2 (PGE2) Synthesis and Degradation Enzymes during Differentiation of Immortalized Urothelial Cells from Patients with Interstitial Cystitis/Painful Bladder Syndrome. PLoS ONE. 2015;10:e0129466 pubmed publisher
    ..We measured immunoprotein expression of cyclooxygenase-2 (COX-2), prostaglandin E2 synthase (PGES) and 15-hydroxyprostaglandin dehydrogenase (PGDH) in human urothelial cells and in immortalized urothelial cells ..
  56. Sun Y, Zhang Y, Zhu Y, Zhang A, Huang S, Yin X, et al. Inhibition of mitochondrial complex-1 restores the downregulation of aquaporins in obstructive nephropathy. Am J Physiol Renal Physiol. 2016;311:F777-F786 pubmed publisher
    ..mechanisms in mediating the rotenone effects on AQPs, we examined the regulation of the COX-2/microsomal prostaglandin E synthase (mPGES)-1/PGE2/EP pathway and found that COX-2, mPGES-1, and renal PGE2 content ..
  57. Uchida K, Takano S, Matsumoto T, Nagura N, Inoue G, Itakura M, et al. Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-α stimulation of synovial cells: an in vitro study. BMC Musculoskelet Disord. 2017;18:283 pubmed publisher
    ..type 1 motif, 4 (ADAMTS-4); and of the pain-related molecules cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1), and nerve growth factor (NGF)...
  58. Saengarun C, Petsom A, Tungasmita D. Etherification of Glycerol with Propylene or 1-Butene for Fuel Additives. ScientificWorldJournal. 2017;2017:4089036 pubmed publisher
    ..over acidic heterogeneous catalysts, Amberlyst-15, S100, and S200 resins, produced mono-propyl glycerol ethers (MPGEs), 1,3-di- and 1,2-di-propyl glycerol ethers (DPGEs), and tri-propyl glycerol ether (TPGE)...
  59. Hamza A, Tong M, Abdulhameed M, Liu J, Goren A, Tai H, et al. Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis. J Phys Chem B. 2010;114:5605-16 pubmed publisher
    Microsomal prostaglandin E synthase-1 (mPGES-1) is an essential enzyme involved in a variety of diseases and is the most promising target for the design of next-generation anti-inflammatory drugs...
  60. Funk C, Furci L, Fitzgerald G, Grygorczyk R, Rochette C, Bayne M, et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem. 1993;268:26767-72 pubmed
    ..In summary, therefore, we have cloned the human EP1 receptor subtype which is functionally coupled to an increase in intracellular Ca2+. ..
  61. Huang Z, Ge Y, Jing J, Wu L, Zhou Z, Zhu Q, et al. [Effect of secretin on the expression of cPLA2 and mPGEs-1 in mouse endometrial stromal cell during early pregnancy]. Sheng Li Xue Bao. 2016;68:725-732 pubmed
    ..of secretin, secretin receptor, cytosolic phospholipase A2 (cPLA2) and membrane prostaglandin E synthase 1 (mPGEs-1) were detected in the mice uterus from day 4 to 8 of pregnancy by real-time PCR, ELISA and in ..
  62. Zhuang Y, Jia Z, Hu C, Ding G, Zhang X, Zhang Y, et al. Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb. Oncotarget. 2017;8:75808-75821 pubmed publisher
    ..Meanwhile, NLRP3 and mPGES-1 were stimulated in NKCC2 positive tubules (thick ascending limb, TAL) paralleled with increased urinary PGE2 ..
  63. Ikeda Matsuo Y. The Role of mPGES-1 in Inflammatory Brain Diseases. Biol Pharm Bull. 2017;40:557-563 pubmed publisher
    ..Therefore, to elucidate the role of PGE2, studies of microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal enzyme for PGE2 synthesis, have recently been an active ..
  64. Stark K, Bylund J, Torma H, Sahlén G, Oliw E. On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens. Prostaglandins Other Lipid Mediat. 2005;75:47-64 pubmed
    ..Recombinant CYP4F8 was also found to catalyze n-2 hydroxylation of PGI2 and carbaprostacyclin (Km to approximately 40 microM), and n-2 and n-3 hydroxylation of carbocyclic TXA2. ..
  65. Golijanin D, Tan J, Kazior A, Cohen E, Russo P, Dalbagni G, et al. Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. Clin Cancer Res. 2004;10:1024-31 pubmed
    ..Cyclooxygenase (COX) catalyzes the synthesis of PGH2, which is converted, in turn, by microsomal prostaglandin E synthase (mPGES-1) to PGE2...
  66. Gómez Hernández A, Martin Ventura J, Sánchez Galán E, Vidal C, Ortego M, Blanco Colio L, et al. Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB. Atherosclerosis. 2006;187:139-49 pubmed
    Prostaglandin E2 (PGE(2), a product of the cyclooxygenase 2 (COX-2) and membrane-associated Prostaglandin E Synthase (mPGES-1) pathway, has been implicated in the instability of atherosclerotic plaques...
  67. Poole E, Hsu L, Xiao L, Kulmacz R, Carlson C, Rabinovitch P, et al. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2010;19:547-57 pubmed publisher
    ..We investigated candidate and tagSNPs in PGE2 synthase (PGES), PGE2 receptors (EP2 and EP4), and prostaglandin dehydrogenase (PGDH) in a case-control study of adenomas (n = 483)..
  68. Zang S, Ni M, Lian Y, Zhang Y, Liu J, Huang A. Expression of microsomal prostaglandin E2 synthase-1 and its role in human hepatocellular carcinoma. Hum Pathol. 2013;44:1681-7 pubmed publisher
    ..Taken together, mPGES1 expression was associated with multiple malignant characteristics and enhanced tumorigenesis in HCC and may serve as an important clinical and pharmacologic biomarker. ..
  69. Kim S, Hashimoto Y, Cho S, Roszik J, Milton D, Dal F, et al. Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. Pigment Cell Melanoma Res. 2016;29:297-308 pubmed publisher
    ..Our findings support the value of a prognostic and predictive role for mPGES1, and suggest targeting this molecule in the PGE2 pathway as another avenue toward improving melanoma therapy. ..
  70. Di Micco S, Terracciano S, Cantone V, Fischer K, Koeberle A, Foglia A, et al. Discovery of new potent molecular entities able to inhibit mPGES-1. Eur J Med Chem. 2018;143:1419-1427 pubmed publisher
    b>mPGES-1, a glutathione-dependent membrane protein is involved in the last step of PGE2 production and has been well recognized as a strategic target for the development of anti-inflammatory and anti-cancer agents...
  71. Wang H, Hsueh C, Lin C, Chou T, Hsu W, Wang L, et al. Clinical implications of microsomal prostaglandin e synthase-1 overexpression in human non-small-cell lung cancer. Ann Surg Oncol. 2006;13:1224-34 pubmed
    Microsomal prostaglandin E synthase-1 (mPGES-1) has recently been found to overexpress in human cancers, including non-small-cell lung cancer (NSCLC). However, the clinical value is largely unknown...
  72. Liu H, Li X, Yang Q, Miao W, Qi S, Song X, et al. [COX-2 and mPGES-1 expression in carotid atherosclerotic plaques]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007;24:453-6 pubmed
    ..changes in the expressions of inducible cyclooxygenase type 2 (COX-2) and membrane associated prostaglandin E-1(mPGES-1) in human carotid atherosclerotic plaques and to explore possible mechanisms of inflammatory process involved in ..
  73. Lu D, Han C, Wu T. Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression. Gastroenterology. 2011;140:2084-94 pubmed publisher
    Microsomal prostaglandin E synthase-1 (mPGES-1) is a rate-limiting enzyme that is coupled with cyclooxygenase (COX)-2 in the synthesis of prostaglandin E2...
  74. Hiraiwa H, Sakai T, Mitsuyama H, Hamada T, Yamamoto R, Omachi T, et al. Inflammatory effect of advanced glycation end products on human meniscal cells from osteoarthritic knees. Inflamm Res. 2011;60:1039-48 pubmed publisher
    ..Expression of cyclooxygenase (COX)-1, COX-2, membrane associated prostaglandin E synthase (mPGES)-1 and cytosolic PGES (cPGES) was analyzed by real-time reverse transcription polymerase chain ..
  75. Alcolea S, Anton R, Camacho M, Soler M, Alfranca A, Avilés Jurado F, et al. Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2. J Lipid Res. 2012;53:630-42 pubmed publisher
    ..cell lines and fibroblasts, which was consistent with an upregulation of COX-2 and microsomal PGE-synthase-1 (mPGES-1) in fibroblasts...
  76. Liu C, Chen S, Wang X, Chen Y, Tang N. 15d-PGJ? decreases PGE? synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter. Biochem Pharmacol. 2014;91:337-47 pubmed publisher
    b>Microsomal prostaglandin E synthase 1 (mPGES-1) is the terminal regulator of PGE? synthesis. The expression of mPGES-1 is increased by stimulating inflammatory factors in various human cancers...
  77. Muthukaman N, Tambe M, Shaikh M, Pisal D, Deshmukh S, Tondlekar S, et al. Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model. Bioorg Med Chem Lett. 2017;27:2594-2601 pubmed publisher
    ..substituted tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives have been synthesized and their mPGES-1 biological activity has been disclosed in detail...
  78. Sinderewicz E, Grycmacher K, Boruszewska D, Kowalczyk Zieba I, Staszkiewicz J, Ślężak T, et al. Bovine ovarian follicular growth and development correlate with lysophosphatidic acid expression. Theriogenology. 2018;106:1-14 pubmed publisher
    ..factor, a number of novel factors are suggested as important regulators of follicular growth and development: PGES, TFG, CD36, RABGAP1, DBI and BTC...
  79. Jakobsson P, Morgenstern R, Mancini J, Ford Hutchinson A, Persson B. Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism. Protein Sci. 1999;8:689-92 pubmed
    ..In addition, homologues are identified in plants, fungi, and bacteria, demonstrating this superfamily to be generally occurring. ..
  80. Premyslova M, Li W, Alfaidy N, Bocking A, Campbell K, Gibb W, et al. Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells. J Clin Endocrinol Metab. 2003;88:6040-7 pubmed
    ..the effect of chorioamnionitis on the protein expression of microsomal and cytosolic prostaglandin E(2) synthases (mPGES and cPGES) in preterm human placentae (PL) and fetal membranes (FM), by Western blot and immunohistochemistry, as ..
  81. Ackerman W, Summerfield T, Vandre D, Robinson J, Kniss D. Nuclear factor-kappa B regulates inducible prostaglandin E synthase expression in human amnion mesenchymal cells. Biol Reprod. 2008;78:68-76 pubmed
    ..b>Prostaglandin E synthase (PTGES, also known as microsomal PGE synthase-1) acts downstream of PTGS2 and is inducibly expressed in ..
  82. Lee J, Natsuizaka M, Ohashi S, Wong G, Takaoka M, Michaylira C, et al. Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis. 2010;31:427-34 pubmed publisher
    ..carbonic anhydrase 9, insulin-like growth factor binding protein-3 (IGFBP3) and cyclooxygenase (COX)-2, prostaglandin E synthase (PTGES) was identified as a novel target gene among the commonly upregulated genes in ESCC as well as the ..
  83. El Mansouri F, Nebbaki S, Kapoor M, Afif H, Martel Pelletier J, Pelletier J, et al. Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1?-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes. Arthritis Res Ther. 2014;16:R113 pubmed publisher
    b>Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE2, a critical mediator in the pathophysiology of osteoarthritis (OA)...
  84. Xia Z, Yan A. Computational models for the classification of mPGES-1 inhibitors with fingerprint descriptors. Mol Divers. 2017;21:661-675 pubmed publisher
    Human microsomal prostaglandin [Formula: see text] synthase (mPGES)-1 is a promising drug target for inflammation and other diseases with inflammatory symptoms...
  85. Kang X, Qiu J, Li Q, Bell K, Du Y, Jung D, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017;7:9459 pubmed publisher
    ..Inhibiting COX-2 or microsomal prostaglandin E synthase-1 suppressed the 6-OHDA-triggered PGE2 production in these cells...
  86. Li S, Sun Z, Ding G, Gong W, Yu J, Xia W, et al. mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation. Cell Physiol Biochem. 2017;43:271-281 pubmed publisher
    ..Thus, the present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived Prostaglandin E2 (PGE2) in IS-induced MC proliferation...
  87. Cardelli R, Vanni G, Marchini F, Saviozzi A. Characterization and origin of organic and inorganic pollution in urban soils in Pisa (Tuscany, Italy). Environ Monit Assess. 2017;189:554 pubmed publisher
    ..by analyzing total petroleum hydrocarbons (TPHs), Cd, Cr, Cu, Hg, Mn, Ni, Pb, Zn, and the platinum group elements (PGEs). The risk was evaluated by the geological accumulation index (I geo) and the enrichment factor (EF)...
  88. Giacomini E, Giordani L, Di Modugno F, Chersi A, Luzzati A. Increased PGE2 production mediates the in vitro inhibitory effect of the human immunodeficiency virus P24 immunosuppressive heptapeptide Ch7. Scand J Immunol. 1998;48:248-53 pubmed
  89. Chaudhry U, Zhuang H, Crain B, DORE S. Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease. Alzheimers Dement. 2008;4:6-13 pubmed publisher
    ..disease (AD), but the cerebral distribution and expression patterns of microsomal prostaglandin-E synthase (mPGES)-1 have not been compared with those of normal human brains...
  90. Sandee D, Sivanuntakorn S, Vichai V, Kramyu J, Kirtikara K. Up-regulation of microsomal prostaglandin E synthase-1 in COX-1 and COX-2 knock-out mouse fibroblast cell lines. Prostaglandins Other Lipid Mediat. 2009;88:111-6 pubmed publisher
    ..knock-out (K/O) cells whereas the expression of cytosolic PGES was not changed indicating that the induction of mPGES-1 may, at least in part, contribute to the substantial increase of PGE(2) production in COX K/O cell lines...
  91. Lian Y, Liu J, Wang X, Zang S, Huang A. [Role of mPGES-1 in the occurrence, progression, metastasis and invasion of hepatocellular carcinoma]. Zhonghua Gan Zang Bing Za Zhi. 2011;19:356-61 pubmed publisher
    To study the expression of mPGES-1 in hepatocellular carcinoma (HCC), observe the effect of MK886 on down-regulation of mPGES-1 gene expression on the biology of human hepatocarcinoma cell line HepG2 and to investigate its significance ..
  92. He S, Wu Y, Yu D, Lai L. Microsomal prostaglandin E synthase-1 exhibits one-third-of-the-sites reactivity. Biochem J. 2011;440:13-21 pubmed publisher
    mPGES-1 (microsomal prostaglandin E synthase-1) is a newly recognized target for the treatment of inflammatory diseases...