prostacyclin receptor

Summary

Gene Symbol: prostacyclin receptor
Description: prostaglandin I2 (prostacyclin) receptor (IP)
Alias: PRIPR, prostacyclin receptor, PGI receptor, PGI2 receptor, prostaglandin I2 receptor, prostanoid IP receptor
Species: human

Top Publications

  1. ncbi Internalization and sequestration of the human prostacyclin receptor
    E M Smyth
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:32037-45. 2000
  2. ncbi Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction
    Z Zhang
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 60:480-7. 2001
  3. ncbi Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway
    Oliver P Milling Smith
    Medical Research Council Human Reproductive Science Unit, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, Scotland, UK
    Endocrinology 147:1697-705. 2006
  4. doi Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells
    Elizebeth C Turner
    UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Mol Biol 386:579-97. 2009
  5. ncbi Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c
    E M Smyth
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:23258-66. 1998
  6. ncbi Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling
    O A Lawler
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 276:33596-607. 2001
  7. ncbi Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 277:15439-44. 2002
  8. ncbi Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences
    Sinead M Miggin
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 277:27053-64. 2002
  9. ncbi The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 278:4250-7. 2003
  10. ncbi Activation-dependent internalization of the human prostacyclin receptor
    Emer M Smyth
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 507:295-301. 2002

Research Grants

  1. Pharmacogenetics of the human prostacyclin receptor.
    John Hwa; Fiscal Year: 2013
  2. Sofiyan Saleem; Fiscal Year: 2015
  3. Pathobiology of Severe Pulmonary Hypertension
    Norbert Voelkel; Fiscal Year: 2005
  4. Oxidative Modifications in Atherogenesis
    Garret FitzGerald; Fiscal Year: 2006
  5. The Role of Central Melanocortins in Cachexia
    Daniel Marks; Fiscal Year: 2006
  6. Ethanol sensitivity--native /recombinant NMDA receptors
    John Woodward; Fiscal Year: 2006
  7. ETHANOL SENSITIVITY OF NATIVE AND CLONED NMDA RECEPTORS
    John Woodward; Fiscal Year: 2009

Patents

  1. T cell activating gene

Detail Information

Publications168 found, 100 shown here

  1. ncbi Internalization and sequestration of the human prostacyclin receptor
    E M Smyth
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:32037-45. 2000
    ....
  2. ncbi Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction
    Z Zhang
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 60:480-7. 2001
    ..Our findings demonstrate greater glycosylation at N(78) compared with N(7). The extent of N-linked glycosylation of hIP may be important for membrane localization, ligand binding, and signal transduction...
  3. ncbi Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway
    Oliver P Milling Smith
    Medical Research Council Human Reproductive Science Unit, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, Scotland, UK
    Endocrinology 147:1697-705. 2006
    ..These data suggest that PGI-IP interaction within glandular epithelial cells can promote the expression of proangiogenic genes in human endometrium via cross talk with the EGFR...
  4. doi Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells
    Elizebeth C Turner
    UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Mol Biol 386:579-97. 2009
    ..However, the factors regulating expression of the prostacyclin receptor (IP) gene in humans and in other species have not been identified...
  5. ncbi Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c
    E M Smyth
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:23258-66. 1998
    Agonist-induced phosphorylation of an epitope-tagged prostacyclin receptor (HAhIP) is mediated primarily by PKC (Smyth, E. M., Nestor, P. V., and FitzGerald G. A. (1996) J. Biol. Chem. 271, 33698-33704)...
  6. ncbi Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling
    O A Lawler
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 276:33596-607. 2001
    The prostacyclin receptor (IP) is primarily coupled to G alpha(s)-dependent activation of adenylyl cyclase; however, a number of studies indicate that the IP may couple to other secondary effector systems perhaps in a species-specific ..
  7. ncbi Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 277:15439-44. 2002
    The human prostacyclin receptor (hIP) is a seven transmembrane-spanning G-protein-coupled receptor that plays an important role in vascular homeostasis...
  8. ncbi Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences
    Sinead M Miggin
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 277:27053-64. 2002
    We recently identified a novel mechanism explaining how the mouse (m) prostacyclin receptor (IP) couples to Galpha(s), Galpha(i), and Galpha(q) (Lawler, O. A., Miggin, S. M., and Kinsella, B. T. (2001) J. Biol. Chem...
  9. ncbi The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 278:4250-7. 2003
    The human prostacyclin receptor is a seven-transmembrane alpha-helical G-protein coupled receptor, which plays important roles in both vascular smooth muscle relaxation as well as prevention of blood coagulation...
  10. ncbi Activation-dependent internalization of the human prostacyclin receptor
    Emer M Smyth
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 507:295-301. 2002
  11. ncbi Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor
    Vincent Giguere
    Division of Rheumatology, Faculty of Medecine and Clinical Research Center, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Eur J Pharmacol 494:11-22. 2004
    ..The prostanoid IP receptor is a G-protein-coupled receptor...
  12. ncbi Clusters of transmembrane residues are critical for human prostacyclin receptor activation
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 43:8974-86. 2004
    ..These critical residues localized to four distinct clusters (analysis via a rhodopsin-based human prostacyclin receptor homology model). Residues Y75(2.65) (TMII), F95(3.28) (TMIII), and R279(7...
  13. ncbi Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6
    Stephen J Wilson
    Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:11780-6. 2006
    ..Recycling of IP, but not IPSSLC, upon agonist removal was facilitated by overexpression of PDE6delta. Thus PDE6delta interacts specifically with IP to modulate receptor trafficking...
  14. ncbi Versatility and differential roles of cysteine residues in human prostacyclin receptor structure and function
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 281:37227-36. 2006
    ..Here we report distinctive roles for extracellular- and transmembrane-located cysteine residues in human prostacyclin receptor structure-function...
  15. pmc Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR)
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    Gene 396:180-7. 2007
    The human prostacyclin receptor (hIP) has recently been recognized as an important seven transmembrane G-protein coupled receptor that plays critical roles in atheroprevention and cardioprotection...
  16. pmc New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues
    J Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    Br J Pharmacol 152:513-22. 2007
    The human prostacyclin receptor (hIP), a G-protein coupled receptor (GPCR) expressed mainly on platelets and vascular smooth muscle cells, plays important protective roles in the cardiovascular system...
  17. pmc Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition
    Eric Arehart
    Department of Pharmacology and Toxicology, Dartmouth Hitchcock Medical Center, Hanover, NH 03755, USA
    Circ Res 102:986-93. 2008
    ..Using a naturally occurring mutation in the prostacyclin receptor, we report for the first time that a deficiency in prostacyclin signaling through its G protein-coupled ..
  18. pmc Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPase
    Martina B O'Keeffe
    School of Biomolecular and Biomedical Sciences, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochim Biophys Acta 1783:1914-28. 2008
    The human prostacyclin receptor (hIP) undergoes rapid agonist-induced internalization by largely unknown mechanism(s)...
  19. doi Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study
    Paola Patrignani
    Department of Medicine and Aging, G D Annunzio University, Chieti, Italy
    Pharmacogenet Genomics 18:611-20. 2008
    ..sex, indexes of systemic inflammation and metabolic status, n=20), we studied (i) differences on systemic markers of vascular disease and platelet activation and (ii) the influence of prostacyclin receptor gene (PTGIR) polymorphisms.
  20. doi Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase
    Katarina Wikström
    UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Cell Signal 20:2332-46. 2008
    The human prostacyclin receptor (hIP) undergoes agonist-induced internalization but the mechanisms regulating its intracellular trafficking and/or recycling to the plasma membrane are poorly understood...
  21. doi Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERalpha-dependent mechanism
    Elizebeth C Turner
    UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Mol Biol 396:473-86. 2010
    Prostacyclin and the prostacyclin receptor (IP) are implicated in mediating many of the atheroprotective effects of estrogen in both humans and in animal models but through unknown mechanisms...
  22. pmc Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation
    Helen M Reid
    School of Biomolecular and Biomedical Sciences, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 285:18709-26. 2010
    The human prostacyclin receptor (hIP) undergoes agonist-induced internalization and subsequent recyclization in slowly recycling endosomes involving its direct physical interaction with Rab11a...
  23. pmc Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 286:7060-9. 2011
    ..Using human population-based studies (n = 1,761) to search for dysfunctional human prostacyclin receptor (hIP) variants, we recently discovered 18 non-synonymous mutations, all with frequencies less than 2% in ..
  24. ncbi The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling
    J S Hayes
    Department of Biochemistry, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 274:23707-18. 1999
    The prostacyclin receptor (IP), a G protein-coupled receptor, mediates the actions of the prostanoid prostacyclin and its mimetics...
  25. ncbi Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor
    Sinead M Miggin
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    Eur J Biochem 269:1714-25. 2002
    In the current study, we have established that the human (h) prostacyclin receptor (IP) is isoprenylated in whole cells...
  26. ncbi Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation
    Sinead M Miggin
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 278:6947-58. 2003
    We have previously established that isoprenylation of the prostacyclin receptor (IP) is required for its efficient G protein coupling and effector signaling (Hayes, J. S., Lawler, O. A., Walsh, M. T., and Kinsella, B. T. (1999) J. Biol...
  27. pmc The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor
    Sarah J O'Meara
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem J 386:177-89. 2005
    Like Ras, farnesylation of the IP (prostacyclin receptor) is required for its efficient intracellular signalling, and hence the IP represents a potential target for inhibition by FTIs [FTase (farnesyl protein transferase) inhibitors]...
  28. pmc Endothelium modulates vasoconstrictor response to prostaglandin I2 in rat mesenteric resistance arteries: interaction between EP1 and TP receptors
    F E Xavier
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Recife, Brazil
    Br J Pharmacol 158:1787-95. 2009
    ..We studied the vasomotor responses to PGI(2) in resistance arteries and the role of thromboxane (TP) and prostaglandin E(2) (EP) receptors in this effect...
  29. pmc Effects of acute and chronic ethanol on cyclic AMP accumulation in NG108-15 cells: differential dependence of changes on extracellular adenosine
    E Kelly
    Department of Pharmacology, School of Medical Sciences, University of Bristol
    Br J Pharmacol 114:1433-41. 1995
    ..ethanol (1-200 mM) displayed concentration-dependent increases in basal and iloprost-stimulated (300 nM; a prostanoid IP receptor agonist) cyclic AMP accumulation but a concentration-dependent decrease in forskolin-stimulated (10 microM)..
  30. pmc Cytoprotection by iloprost against paracetamol-induced toxicity in hamster isolated hepatocytes
    P Nasseri Sina
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Br J Pharmacol 105:417-23. 1992
    ..The mechanism of action of iloprost probably does not involve induction of prostaglandin synthesis or activation of the previously-characterized prostacyclin receptor.
  31. ncbi Appearance of a novel prostacyclin receptor antibody and duration of spinal cord injury
    Nighat N Kahn
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Spinal Cord Med 28:97-102. 2005
    ..Previously, we have identified a novel circulating antibody (IgG) in persons with SCI that specifically blocks the high-affinity prostacyclin (PGI2) receptors on the platelet surface without affecting the low-affinity PGI2 receptors...
  32. doi The roles of prostanoids in infection and sickness behaviors
    Toshiyuki Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    J Infect Chemother 14:270-8. 2008
    ..are eight types of prostanoid receptors: the PGD receptor, four subtypes of PGE receptor, the PGF receptor, the PGI receptor, and the TXA receptor...
  33. ncbi Prostaglandin receptor signaling in disease
    Toshiyuki Matsuoka
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan matsuoka mfour med kyoto u ac jp
    ScientificWorldJournal 7:1329-47. 2007
    ..are the PGD receptor (DP), four subtypes of the PGE receptor (EP1, EP2, EP3, and EP4), the PGF receptor (FP), PGI receptor (IP), and TXA receptor (TP)...
  34. pmc Molecular biology of histidine decarboxylase and prostaglandin receptors
    Atsushi Ichikawa
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 86:848-66. 2010
    ..mouse L-histidine decarboxylase (HDC) and 6 mouse prostanoid receptors (4 PGE(2) receptors, PGF receptor, and PGI receptor). We then characterized the expression patterns and functions of these genes...
  35. doi Regulation of cytokine expression in human plasmacytoid dendritic cells by prostaglandin I2 analogues
    C H Hung
    Dept of Paediatrics, Kaohsiung Medical University Hospital, No 100, Tz You 1st Road, Kaohsiung 807, Taiwan
    Eur Respir J 33:405-10. 2009
    ....
  36. ncbi Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha
    P Kunapuli
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:27147-54. 1997
    ..12-iso-PGF2alpha caused a dose-dependent activation of the FP, it failed to activate the recombinant human prostacyclin receptor and caused only minimal activation of the thromboxane receptor isoforms stably expressed in HEK 293 cells...
  37. pmc Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
    Ralph T Schermuly
    University of Giessen Lung Center, Medical Clinic II V, Justus Liebig University Giessen, 35392 Giessen, Germany
    Respir Res 8:4. 2007
    ..The rapid desensitization of the human prostacyclin (IP) in response to agonist binding has been shown in cell culture. Phosphorylation of the IP receptor by protein kinase C (PKC) has been suggested to be involved in this process...
  38. doi Prostanoids and inflammation: a new concept arising from receptor knockout mice
    Shuh Narumiya
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Mol Med (Berl) 87:1015-22. 2009
    ..a family of G-protein-coupled receptors designated PGD receptor, PGE receptor subtypes EP1-EP4, PGF receptor, PGI receptor, and TX receptor to elicit their actions...
  39. ncbi A selective binding site for 3H-NECA that is not an adenosine A2 receptor
    M Keen
    Department of Pharmacology, Medical School, University of Birmingham, U K
    Biochem Pharmacol 38:3827-33. 1989
    ..of subsequent responses to all the adenosine analogues, with no effect on subsequent responses to a prostacyclin receptor agonist or NaF. This suggests that all the adenosine analogues examined activate an adenosine A2 receptor...
  40. doi Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice
    Laura Popp
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, Haus 74, Rm 437, 60590 Frankfurt am Main, Germany
    Eur J Pain 13:691-703. 2009
    ..Thromboxane and prostacyclin receptor knockout mice showed normal pain behavior in all tests...
  41. pmc Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts
    Xiaoqiu Liu
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Ave, Crowe 115, Memphis, TN 38163, USA
    Naunyn Schmiedebergs Arch Pharmacol 377:359-69. 2008
    ..AC6 is completely compartmentized in lipid raft domains where it is activated solely by coresident G protein-coupled receptors to regulate cardiac fibroblast function...
  42. pmc A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor
    Cheng Huai Ruan
    Vascular Biology Research Center, Division of Hematology, Department of Internal Medicine, The University of Texas Health Science Center, Houston, Texas 77030, USA
    BMC Biochem 6:23. 2005
    b>Prostacyclin receptor (IP) and thromboxane A2 receptor (TP) belong to rhodopsin-type G protein-coupling receptors and respectively bind to prostacyclin and thromboxane A2 derived from arachidonic acid...
  43. ncbi The role of the prostacyclin receptor antagonist RO3244019 in treating neurogenic detrusor overactivity after spinal cord injury in rats
    Mohit Khera
    Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA
    BJU Int 99:442-6. 2007
    To determine the effects of the prostacyclin receptor (IP) antagonist RO3244019 on neurogenic detrusor overactivity (NDO) in spinal cord-injured (SCI) neurogenic bladder of the rat.
  44. doi Prostacyclin-induced peroxisome proliferator-activated receptor-alpha translocation attenuates NF-kappaB and TNF-alpha activation after renal ischemia-reperfusion injury
    Hsi Hsien Chen
    Graduate Institute of Clinical Medicine, College of Medicine, Taipai Medical University, Taiwan
    Am J Physiol Renal Physiol 297:F1109-18. 2009
    ..Using a cAMP inhibitor (CAY10441) and a prostacyclin receptor antibody, we also found that there was another prostacyclin/IP receptor/cAMP pathway that could inhibit ..
  45. ncbi Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats
    Y Numaguchi
    Internal Medicine II, Nagoya University School of Medicine, Japan
    Cardiovasc Res 41:682-8. 1999
    ..The aim of this study was to evaluate the possible role of prostacyclin (PGI2) in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR)...
  46. ncbi Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin
    Krzysztof Bryniarski
    Department of Immunology Jagiellonian University Medical College, Krakow, Poland
    Eur J Pharmacol 578:332-8. 2008
    ..Interestingly, in the presence of prostanoid IP receptor antagonist R-3-(4-fluoro-phenyl)-2-[5-(4-fluoro-phenyl)-benzofuran-2-ylmethoxycarbonylamino]-propionic ..
  47. doi Prostaglandin I(2) analogues enhance growth-related oncogene-alpha expression in human monocyte-derived dendritic cells
    Chang Hung Kuo
    Department of Pediatrics, Kaohsiung Municipal Ta Tung Hospital, Kaohsiung, Taiwan, Republic of China
    Inflammation 33:334-43. 2010
    ..These effects should be considered for PGI(2) analogues as candidates for the treatment of asthma...
  48. ncbi Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins
    M Sussmann
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Germany
    Circ Res 94:592-600. 2004
    ..HAS2 mRNA levels were also stimulated by a selective prostacyclin receptor (IP) agonist, cicaprost (10 nmol/L), prostaglandin E(2) (10 nmol/L), and the EP(2) receptor agonist, ..
  49. ncbi Functional role of prostacyclin receptor in rat dorsal root ganglion neurons
    Koichi Nakae
    TRA Urology, Research Center Kyoto, Bayer Yakuhin, Ltd, 6 5 1 3 Kunimidai, Kizu cho, Soraku gun, Kyoto 619 0216, Japan
    Neurosci Lett 388:132-7. 2005
    ..In the present study, PCR experiments revealed that one of prostanoid receptor, prostacyclin receptor (IP receptor) was expressed in L6 and S1 rat DRG neurons and that the expression of IP receptor was not ..
  50. doi Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity
    Saeko Nakajima
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Immunol 184:5595-603. 2010
    ..These results suggest that PGI(2)-IP signaling promotes Th1 differentiation through a cAMP-protein kinase A pathway and thereby initiates acquired cutaneous immune responses...
  51. ncbi Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1
    Hui Fang Cheng
    George M O Brien Kidney Disease Center, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Regul Integr Comp Physiol 283:R638-46. 2002
    ..The persistent response in EP(2) nulls suggests involvement of prostaglandin E(2) receptor subtype 4 and/or prostacyclin receptor (IP).
  52. ncbi Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor
    E M Smyth
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 271:33698-704. 1996
    An epitope-tagged human prostacyclin receptor (HAhIP) was constructed and stably transfected into human embryonic kidney 293 cells. The receptor exhibited high (Kd = 0.4 +/- 0.08 nM, Bmax = 0.7 +/- 0...
  53. ncbi Prostaglandin receptors in the kidney: a new route for intervention?
    M D Breyer
    Department of Veterans Affairs Medical Center and Vanderbilt University, Department of Medicine, Nashville, Tenn 37232, USA
    Exp Nephrol 6:180-8. 1998
    ..Other intrarenal prostanoid receptors include the thromboxane A2 receptor and the prostacyclin receptor. These receptors also exhibit a discrete intrarenal distribution...
  54. ncbi Effects of the selective prostacyclin receptor antagonist RO3244019 on the micturition reflex in rats
    Joseph S Cefalu
    Roche Palo Alto, Palo Alto, California 94304, USA
    J Urol 178:2683-8. 2007
    We investigated the role of prostacyclin on afferent modulation of the micturition reflex using the novel selective prostacyclin receptor antagonist RO3244019 in rat models of bladder function.
  55. pmc Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes
    Shaquria P Adderley
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Am J Physiol Heart Circ Physiol 298:H587-93. 2010
    Activation of the beta-adrenergic receptor (beta-AR) or the prostacyclin receptor (IPR) results in increases in cAMP and ATP release from erythrocytes...
  56. doi Activation of prostanoid EP receptors by prostacyclin analogues in rabbit iliac artery: implications for anti-restenotic potential
    Christopher McCormick
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnot Building, 27 Taylor Street, Glasgow, United Kingdom
    Eur J Pharmacol 641:160-7. 2010
    ..have the potential to be effective agents in a new generation of drug-eluting stents by virtue of prostanoid IP receptor mediated anti-proliferative effects on smooth muscle cells...
  57. pmc Endothelin-1 (ET-1) increases the expression of remodeling genes in vascular smooth muscle through linked calcium and cAMP pathways: role of a phospholipase A(2)(cPLA(2))/cyclooxygenase-2 (COX-2)/prostacyclin receptor-dependent autocrine loop
    Karl Deacon
    Division of Respiratory Medicine, Centre for Respiratory Research, University of Nottingham, City Hospital Site, Hucknall Road, Nottingham, UK
    J Biol Chem 285:25913-27. 2010
    ..These studies revealed activation pathways involving a cyclooxygenase-2 (COX-2)/prostacyclin receptor (IP receptor) autocrine loop and an interlinked calcium-dependent pathway...
  58. ncbi Mechanism of permissive prostacyclin action in cerebrovascular smooth muscle
    C W Leffler
    Department of Physiology, The University of Tennessee Health Science Center, Memphis 38163, USA
    Prostaglandins Other Lipid Mediat 66:145-53. 2001
    Prostacyclin permissively allows increased cAMP and cerebral vasodilation to hypercapnia in piglets. The prostacyclin receptor (IP) is coupled to phospholipase C (PLC) in piglet cerebral microvascular smooth muscle cells (SMC)...
  59. ncbi Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia
    Wenhua Wang
    Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Department of Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Cancer 115:582-90. 2005
    ....
  60. doi Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension
    Ying Ju Lai
    University of Giessen Lung Centre, Giessen, Germany
    Am J Respir Crit Care Med 178:188-96. 2008
    ..It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor)...
  61. ncbi Prostacyclin-induced rundown of N-methyl-D-aspartate receptor currents in HEK293 cells is protein kinase A-dependent and NR2 subunit-selective
    John J Woodward
    Department of Physiology and Neuroscience, MUSC, Charleston, USA
    J Neurochem 80:598-604. 2002
    ..In this study, HEK293 cells expressing different NMDA receptor subunits were used to study the effects of prostacyclin receptor-mediated PKA activation on the magnitude of glutamate-activated currents...
  62. ncbi Human fallopian tubes express prostacyclin (PGI) synthase and cyclooxygenases and synthesize abundant PGI
    Jaou Chen Huang
    Department of Obstetrics and Gynecology, University of Texas Medical School at Houston, Institute of Molecular Medicine and Division of Hematology, Texas 77030, USA
    J Clin Endocrinol Metab 87:4361-8. 2002
    ..Western blot analysis revealed the expression of PGI synthase (PGIS) and PGI receptor by fallopian tubes...
  63. ncbi The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin
    Helen M Reid
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 278:51190-202. 2003
    ..to NO/PKG-desensitization, similar to wild type TP alpha its signaling was fully desensitized by the prostacyclin receptor agonist cicaprost occurring through a PKA-dependent mechanism...
  64. ncbi Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives
    Michihiro Ohno
    Pharmaceutical Research Laboratories, Toray Industries Inc, 1, 111 Tebiro, Kamakura, Kanagawa 248 8555, Japan
    J Med Chem 48:5279-94. 2005
    ..was discovered as potent dual-acting agents to block the thromboxane A(2) receptor and to activate the prostacyclin receptor. Synthesis, structure-activity relationship, and in vitro and ex vivo pharmacology of this series of ..
  65. ncbi Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells: role of receptor heterodimerization
    Stephen J Wilson
    Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 27:290-6. 2007
    ..We examined the consequence of IP/TP interaction for the regulatory pathways of both receptors...
  66. doi Aging and prostacyclin responses in aorta and platelets from WKY and SHR rats
    Elodie Gomez
    Départment d Angiologie, Institut de Recherches Servier, 11 rue des Moulineaux 92150 Suresnes, France
    Am J Physiol Heart Circ Physiol 295:H2198-211. 2008
    ..In aorta from 3- and 6-mo-old WKY, prostacyclin and beraprost [prostacyclin receptor (IP) agonists] produced relaxations that were enhanced by Triplion (thromboxane-prostanoid receptor ..
  67. ncbi [Determination of ligand binding domains of the prostanoid receptors]
    T Kobayashi
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Nihon Yakurigaku Zasshi 114:127P-129P. 1999
    ..The region from the sixth transmembrane domain to the carboxyl terminus of the PGI receptor was first replaced by the corresponding region of the PGD receptor...
  68. ncbi Cyclo-oxygenase products and atherothrombosis
    G A Fitzgerald
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Ann Med 32:21-6. 2000
    ..Although deletion of the prostacyclin receptor (the IP) accelerates atherogenesis in the mouse, retention of one copy of the IP is atheroprotective...
  69. ncbi Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists
    Marc Raleigh Brescia
    Pharmacopeia Drug Discovery Inc, PO Box 5350, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 17:1211-5. 2007
    ..05-0.50 microM, demonstrated functional antagonism by inhibiting cAMP production in HEL cells with IC50 values of 0.016-0.070 microM, and exhibited significant selectivity versus other prostanoid receptors...
  70. doi A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active fo
    Keiichi Kuwano
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    J Pharmacol Exp Ther 326:691-9. 2008
    ..NS-304) is an orally available, long-acting nonprostanoid prostacyclin receptor (IP receptor) agonist prodrug...
  71. pmc Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn
    Satyan Lakshminrusimha
    Department of Pediatrics, University of Buffalo, Buffalo, NY, USA
    Pediatr Crit Care Med 10:106-12. 2009
    ..vasodilator and is produced by prostacyclin synthase and stimulates adenylate cyclase (AC) via the prostacyclin receptor (IP) to produce cAMP. Forskolin is a direct stimulant of AC...
  72. pmc Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively
    Peter D Donnellan
    School of Biomolecular and Biomedical Sciences, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Mol Signal 4:7. 2009
    The human prostacyclin receptor (hIP) undergoes agonist-induced phosphorylation, desensitisation and internalisation and may be recycled to the plasma membrane or targeted for degradation by, as yet, unknown mechanism(s).
  73. doi Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: Evidence for Gi/o modulation via EP3 receptors
    Nelson N Orie
    BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, WC1E 6JF, UK
    Eur J Pharmacol 654:258-65. 2011
    ..1μM. In conclusion, prostanoid EP(3) receptors via G(i/o) negatively modulate prostanoid IP receptor-mediated relaxation to cicaprost, iloprost and treprostinil...
  74. doi Beraprost enhances the APC function of B cells by upregulating CD86 expression levels
    Jini Kim
    Department of Microbiology and Immunology, School of Medicine, Kangwon National University, Chuncheon, Gangwon do 200 701, Korea
    J Immunol 186:3866-73. 2011
    ..Results carried out with receptor antagonists revealed that beraprost enhanced CD86 levels by binding to prostacyclin receptor IP and by increasing intracellular cAMP concentrations...
  75. doi Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings
    Mette Stæhr
    Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark
    Am J Physiol Regul Integr Comp Physiol 301:R412-20. 2011
    ..The LPS-induced changes in MAP and HR were not different from control in COX-2(-/-) and eNOS(-/-) mice. A prostacyclin receptor antagonist (BR5064) blocked the hypotensive effect of a prostacyclin agonist (beraprost), but did not ..
  76. doi Effects of estrogen on endothelial prostanoid production and cyclooxygenase-2 and heme oxygenase-1 expression
    Emanuela Marcantoni
    Department of Medicine and Aging, G D Annunzio University, School of Medicine, 66100 Chieti, Italy
    Prostaglandins Other Lipid Mediat 98:122-8. 2012
    ..PGI₂ receptor antagonist RO3244794 did not affect HO-1 induction by E₂. In conclusion, E₂ may restrain oxidant stress in the endothelium through HO-1 induction by a mechanism independent on PGI₂ signaling...
  77. doi Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist
    Brendan J Whittle
    William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Biochem Pharmacol 84:68-75. 2012
    ..Treprostinil may therefore differ from iloprost in its overall beneficial pulmonary vasorelaxant profile and other pharmacological actions, especially in diseases where the IP receptor is down-regulated...
  78. pmc Regulation of the human prostacyclin receptor gene by the cholesterol-responsive SREBP1
    Elizebeth C Turner
    UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Lipid Res 53:2390-404. 2012
    Prostacyclin and its prostacyclin receptor, the I Prostanoid (IP), play essential roles in regulating hemostasis and vascular tone and have been implicated in a range cardio-protective effects but through largely unknown mechanisms...
  79. pmc Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes
    Hakima Mechiche
    Laboratory of Cardiovascular Pharmacology, Université Champagne Ardennes, Reims, France
    PLoS ONE 7:e45273. 2012
    ..Two prostanoid IP receptor agonists (iloprost and beraprost) induced first a marked drop in the beating rate and then definitive ..
  80. pmc New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling
    Raja Chakraborty
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Mol Cell Biol 33:184-93. 2013
    ....
  81. doi Effect of single nucleotide polymorphisms of the prostacyclin receptor gene on platelet activation in Japanese healthy subjects and patients with cerebral infarction
    Mie Shimizu
    Department of Neurology, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    J Clin Neurosci 20:851-6. 2013
    ..In order to clarify whether single nucleotide polymorphisms (SNPs) of the prostacyclin receptor (IP) gene affects platelet activation in ischemic stroke, we investigated the relationship between ..
  82. doi Synergistic effects of prostacyclin analogs and phosphodiesterase inhibitors on cyclic adenosine 3',5' monophosphate accumulation and adenosine 3'5' triphosphate release from human erythrocytes
    Stephanie M Knebel
    Department of Pharmacological and Physiological Science, Saint Louis University, St Louis, MO 63104, USA
    Exp Biol Med (Maywood) 238:1069-74. 2013
    ..relaxation of vascular smooth muscle directly, other cells in circulation, including erythrocytes, express prostacyclin receptor (IPR) and contain PDE5...
  83. pmc Beraprost sodium protects against chronic brain injury in aluminum-overload rats
    Yongquan Pan
    Department of Pharmacology, Chongqing Medical University, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing, 400016, China
    Behav Brain Funct 11:6. 2015
    ..Previous studies suggest that prostacyclin synthase (PGIS) expression and prostacyclin receptor (IP) activation are beneficial for treatment of acute traumatic and ischemic brain injury...
  84. doi Inhibition of cyclooxygenase-2 causes a decrease in coronary flow in diabetic mice. The possible role of PGE2 and dysfunctional vasodilation mediated by prostacyclin receptor
    Tomasz Przygodzki
    Department of Haemostasis and Haemostatic Disorders, Chair of Biomedical Sciences, Medical University of Lodz, Lodz, 92 215, Poland
    J Physiol Biochem 71:351-8. 2015
    ..The use of ONO-1301, a specific agonist for the prostacyclin receptor revealed that vasodilating responses mediated by the receptor were impaired in db/db mice...
  85. doi Prostacyclin receptor (PTGIR) in the porcine endometrium: Regulation of expression and role in luminal epithelial and stromal cells
    Agnieszka Blitek
    Department of Hormonal Action Mechanisms, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland Electronic address
    Theriogenology 84:969-82. 2015
    ..The present study was designed to examine (1) the expression of PGI2 receptor (PTGIR) messenger RNA (mRNA) and protein in the endometrium of cyclic and early-pregnant gilts; (2) possible ..
  86. doi Recent advances in targeting the prostacyclin pathway in pulmonary arterial hypertension
    Irene M Lang
    Division of Cardiology, Medical University of Vienna, Vienna, Austria
    Eur Respir Rev 24:630-41. 2015
    ..pulmonary concentrations of prostacyclin, a prostanoid that targets several receptors including the IP prostacyclin receptor, are reduced...
  87. doi Serelaxin (recombinant human relaxin-2) prevents high glucose-induced endothelial dysfunction by ameliorating prostacyclin production in the mouse aorta
    Hooi Hooi Ng
    School of Biosciences, The University of Melbourne, Parkville, Victoria 3010, Australia Electronic address
    Pharmacol Res 107:220-8. 2016
    ..Our data show that serelaxin treatment for 3 days restores high glucose-induced endothelial dysfunction by ameliorating vasodilator prostacyclin production and possibly through the reduction of superoxide in the mouse aorta. ..
  88. pmc Pharmacokinetics of the novel oral prostacyclin receptor agonist selexipag in subjects with hepatic or renal impairment
    Priska Kaufmann
    Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland
    Br J Clin Pharmacol 82:369-79. 2016
    The aim of the present study was to explore the effect of hepatic or renal dysfunction on the pharmacokinetics (PK), tolerability and safety of selexipag, an orally active prostacyclin receptor agonist.
  89. doi Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects
    Shirin Bruderer
    Actelion Pharmaceuticals Ltd, Allschwil, Switzerland Electronic address
    Clin Ther 38:1228-1236.e1. 2016
    Selexipag is a new orally available nonprostanoid prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Warfarin is commonly used in patients with pulmonary arterial hypertension...
  90. pmc Inhibition of rat colon contractility by prostacyclin (IP-) receptor agonists: involvement of NANC neurotransmission
    Y M Qian
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT
    Br J Pharmacol 115:163-71. 1995
    ..The second transmitter mechanism is apamin-sensitive; the experimental results do not support ATP, adenosine or VIP as transmitter candidates. However, further studies using more potent and selective receptor antagonists are required...
  91. ncbi Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
    T Murata
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Sakyo, Japan
    Nature 388:678-82. 1997
    ..Here we disrupt the gene for the prostacyclin receptor in mice by using homologous recombination...
  92. doi Prostacyclin signaling regulates circulating ghrelin during acute inflammation
    Lisa D Madison
    Department of Pediatrics Neuroscience Graduate Program, Oregon Health and Science University, Portland, Oregon, USA
    J Endocrinol 196:263-73. 2008
    ..The prostacyclin receptor was also expressed in the gastric mucosa, and the majority of ghrelin-producing cells were found to co-..
  93. doi Synthesis of prostacyclin and its effect on the contractile activity of the inflamed porcine uterus
    B Jana
    Division of Reproductive Biology, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland
    Theriogenology 79:470-85. 2013
    ..Our study reveals that inflammation of the porcine uterus upregulates PGI(2) synthesis and that PGI(2) increases contractility, which suggests that PGI(2) might be essential for the course of uterine inflammation...
  94. ncbi Protein kinase A-dependent coupling of mouse prostacyclin receptors to Gi is cell-type dependent
    Kevin B S Chow
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Eur J Pharmacol 474:7-13. 2003
    ..cells and human embryonic kidney 293 (HEK 293) cells expressing the cloned human (hIP) or mouse (mIP) prostacyclin receptor, and compared with data from NG108-15 and SK-N-SH cells that endogenously express rat/mouse and human IP ..
  95. ncbi [Molecular mechanisms for cAMP-independent activation of MaxiK channel: G protein direct channel regulation and contribution to the tuning of vascular smooth muscle tone]
    Fumiko Yamaki
    Departments of Chemical Pharmacology and Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    Nihon Yakurigaku Zasshi 122:37P-39P. 2003
    ..The present study was carried out to elucidate the contribution of MaxiK channel to prostacyclin receptor (IP receptor)-mediated vascular relaxation with a special reference to the role of cAMP...
  96. ncbi Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Pharmacol 512:223-30. 2005
    ..In conclusion, the mechanism responsible for the effect of prostaglandin E1 on lipopolysaccharide-induced responses is distinct from that of prostaglandin E2...
  97. ncbi The effects of non-selective, preferential-selective and selective COX-inhibitors on the growth of experimental and human tumors in mice related to prostanoid receptors
    Christian Cahlin
    Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Department of Surgery, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Int J Oncol 27:913-23. 2005
    ..inhibitor (indomethacin), was related to tumor content of COX-1/COX-2 protein as well as to EP1-EP4 and prostacyclin receptor expression...
  98. pmc RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists
    Keith R Bley
    Roche Palo Alto, Palo Alto, CA 94304, USA
    Br J Pharmacol 147:335-45. 2006
    ..These data suggest that RO1138452 and RO3244794 are potent and selective antagonists for both human and rat IP receptors and that they possess analgesic and anti-inflammatory potential...
  99. doi Regulation of the human prostacyclin receptor gene in megakaryocytes: major roles for C/EBPδ and PU.1
    Garret L Keating
    UCD Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland
    Biochim Biophys Acta 1819:428-45. 2012
    ..Recent studies investigating the regulation of the human prostacyclin receptor (hIP) gene identified an upstream repressor region (URR) within its regulatory promoter, herein termed the ..
  100. pmc Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1
    Gabriel Birrane
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53819. 2013
    ..The actions of prostacyclin are mainly mediated through its activation of the prostacyclin receptor or, in short, the IP...
  101. doi Therapies for pulmonary arterial hypertension: where are we today, where do we go tomorrow?
    Andrei Seferian
    Faculte de Medecine, Universite Paris Sud, Le Kremlin Bicetre, France
    Eur Respir Rev 22:217-26. 2013
    ..Recently oral prostacyclin receptor agonists have shown encouraging results...

Research Grants7

  1. Pharmacogenetics of the human prostacyclin receptor.
    John Hwa; Fiscal Year: 2013
    ..Based upon these observations, we hypothesize that naturally occurring genetic mutations in the human prostacyclin receptor may predispose individuals to disease...
  2. Sofiyan Saleem; Fiscal Year: 2015
    ..will address the hypotheses that increased inflammatory response due to global cerebral ischemia in older prostacyclin receptor ( PGI2) (IP) KO will worsen the learning and memory performance, decrease regional cerebral blood flow (..
  3. Pathobiology of Severe Pulmonary Hypertension
    Norbert Voelkel; Fiscal Year: 2005
    ..Lastly, a severe loss of prostacyclin receptor (PGII-R) expression in the resistance vessels of PPH lungs provides rationale and focus for the ..
  4. Oxidative Modifications in Atherogenesis
    Garret FitzGerald; Fiscal Year: 2006
    ..abstract_text> ..
  5. The Role of Central Melanocortins in Cachexia
    Daniel Marks; Fiscal Year: 2006
    ..Ultimately, this work may lead to investigation of drug therapy for this widespread medical problem. ..
  6. Ethanol sensitivity--native /recombinant NMDA receptors
    John Woodward; Fiscal Year: 2006
    ..The successful completion of this training plan will substantially enhance the PI's research expertise and his ability to fulfill the goals of his research. ..
  7. ETHANOL SENSITIVITY OF NATIVE AND CLONED NMDA RECEPTORS
    John Woodward; Fiscal Year: 2009
    ..Aim 3 will express ethanol-insensitive receptors identified in Aims 1 and 2 in neurons in vitro and in vivo to address which effects of ethanol are mediated by inhibition of NMDA receptors. ..

Patents1

  1. T cell activating gene
    Patent Number: WO2004058805-A2; Date:2004-07-15