prostacyclin receptor

Summary

Gene Symbol: prostacyclin receptor
Description: prostaglandin I2 receptor
Alias: PRIPR, prostacyclin receptor, PGI receptor, PGI2 receptor, prostaglandin I2 (prostacyclin) receptor (IP), prostanoid IP receptor
Species: human
Products:     prostacyclin receptor

Top Publications

  1. Smyth E, Austin S, Reilly M, Fitzgerald G. Internalization and sequestration of the human prostacyclin receptor. J Biol Chem. 2000;275:32037-45 pubmed
    ....
  2. Zhang Z, Austin S, Smyth E. Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction. Mol Pharmacol. 2001;60:480-7 pubmed
    ..Our findings demonstrate greater glycosylation at N(78) compared with N(7). The extent of N-linked glycosylation of hIP may be important for membrane localization, ligand binding, and signal transduction. ..
  3. Arehart E, Stitham J, Asselbergs F, Douville K, MacKenzie T, Fetalvero K, et al. Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res. 2008;102:986-93 pubmed publisher
    ..Using a naturally occurring mutation in the prostacyclin receptor, we report for the first time that a deficiency in prostacyclin signaling through its G protein-coupled ..
  4. Stitham J, Arehart E, Elderon L, Gleim S, Douville K, Kasza Z, et al. Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction. J Biol Chem. 2011;286:7060-9 pubmed publisher
    ..Using human population-based studies (n = 1,761) to search for dysfunctional human prostacyclin receptor (hIP) variants, we recently discovered 18 non-synonymous mutations, all with frequencies less than 2% in ..
  5. Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi M, Horvath R, et al. Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study. Pharmacogenet Genomics. 2008;18:611-20 pubmed publisher
    ..i) differences on systemic markers of vascular disease and platelet activation and (ii) the influence of prostacyclin receptor gene (PTGIR) polymorphisms...
  6. Stitham J, Gleim S, Douville K, Arehart E, Hwa J. Versatility and differential roles of cysteine residues in human prostacyclin receptor structure and function. J Biol Chem. 2006;281:37227-36 pubmed
    ..Here we report distinctive roles for extracellular- and transmembrane-located cysteine residues in human prostacyclin receptor structure-function...
  7. Miggin S, Lawler O, Kinsella B. Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. J Biol Chem. 2003;278:6947-58 pubmed
    We have previously established that isoprenylation of the prostacyclin receptor (IP) is required for its efficient G protein coupling and effector signaling (Hayes, J. S., Lawler, O. A., Walsh, M. T., and Kinsella, B. T. (1999) J. Biol...
  8. Miggin S, Kinsella B. Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences. J Biol Chem. 2002;277:27053-64 pubmed
    We recently identified a novel mechanism explaining how the mouse (m) prostacyclin receptor (IP) couples to Galpha(s), Galpha(i), and Galpha(q) (Lawler, O. A., Miggin, S. M., and Kinsella, B. T. (2001) J. Biol. Chem...
  9. Miggin S, Lawler O, Kinsella B. Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. Eur J Biochem. 2002;269:1714-25 pubmed
    In the current study, we have established that the human (h) prostacyclin receptor (IP) is isoprenylated in whole cells...
  10. Stitham J, Stojanovic A, Hwa J. Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism. J Biol Chem. 2002;277:15439-44 pubmed
    The human prostacyclin receptor (hIP) is a seven transmembrane-spanning G-protein-coupled receptor that plays an important role in vascular homeostasis...

Detail Information

Publications62

  1. Smyth E, Austin S, Reilly M, Fitzgerald G. Internalization and sequestration of the human prostacyclin receptor. J Biol Chem. 2000;275:32037-45 pubmed
    ....
  2. Zhang Z, Austin S, Smyth E. Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction. Mol Pharmacol. 2001;60:480-7 pubmed
    ..Our findings demonstrate greater glycosylation at N(78) compared with N(7). The extent of N-linked glycosylation of hIP may be important for membrane localization, ligand binding, and signal transduction. ..
  3. Arehart E, Stitham J, Asselbergs F, Douville K, MacKenzie T, Fetalvero K, et al. Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res. 2008;102:986-93 pubmed publisher
    ..Using a naturally occurring mutation in the prostacyclin receptor, we report for the first time that a deficiency in prostacyclin signaling through its G protein-coupled ..
  4. Stitham J, Arehart E, Elderon L, Gleim S, Douville K, Kasza Z, et al. Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction. J Biol Chem. 2011;286:7060-9 pubmed publisher
    ..Using human population-based studies (n = 1,761) to search for dysfunctional human prostacyclin receptor (hIP) variants, we recently discovered 18 non-synonymous mutations, all with frequencies less than 2% in ..
  5. Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi M, Horvath R, et al. Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study. Pharmacogenet Genomics. 2008;18:611-20 pubmed publisher
    ..i) differences on systemic markers of vascular disease and platelet activation and (ii) the influence of prostacyclin receptor gene (PTGIR) polymorphisms...
  6. Stitham J, Gleim S, Douville K, Arehart E, Hwa J. Versatility and differential roles of cysteine residues in human prostacyclin receptor structure and function. J Biol Chem. 2006;281:37227-36 pubmed
    ..Here we report distinctive roles for extracellular- and transmembrane-located cysteine residues in human prostacyclin receptor structure-function...
  7. Miggin S, Lawler O, Kinsella B. Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. J Biol Chem. 2003;278:6947-58 pubmed
    We have previously established that isoprenylation of the prostacyclin receptor (IP) is required for its efficient G protein coupling and effector signaling (Hayes, J. S., Lawler, O. A., Walsh, M. T., and Kinsella, B. T. (1999) J. Biol...
  8. Miggin S, Kinsella B. Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences. J Biol Chem. 2002;277:27053-64 pubmed
    We recently identified a novel mechanism explaining how the mouse (m) prostacyclin receptor (IP) couples to Galpha(s), Galpha(i), and Galpha(q) (Lawler, O. A., Miggin, S. M., and Kinsella, B. T. (2001) J. Biol. Chem...
  9. Miggin S, Lawler O, Kinsella B. Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. Eur J Biochem. 2002;269:1714-25 pubmed
    In the current study, we have established that the human (h) prostacyclin receptor (IP) is isoprenylated in whole cells...
  10. Stitham J, Stojanovic A, Hwa J. Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism. J Biol Chem. 2002;277:15439-44 pubmed
    The human prostacyclin receptor (hIP) is a seven transmembrane-spanning G-protein-coupled receptor that plays an important role in vascular homeostasis...
  11. Lawler O, Miggin S, Kinsella B. Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling. J Biol Chem. 2001;276:33596-607 pubmed
    The prostacyclin receptor (IP) is primarily coupled to G alpha(s)-dependent activation of adenylyl cyclase; however, a number of studies indicate that the IP may couple to other secondary effector systems perhaps in a species-specific ..
  12. Stitham J, Stojanovic A, Ross L, Blount A, Hwa J. Clusters of transmembrane residues are critical for human prostacyclin receptor activation. Biochemistry. 2004;43:8974-86 pubmed
    ..These critical residues localized to four distinct clusters (analysis via a rhodopsin-based human prostacyclin receptor homology model). Residues Y75(2.65) (TMII), F95(3.28) (TMIII), and R279(7...
  13. Turner E, Kinsella B. Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERalpha-dependent mechanism. J Mol Biol. 2010;396:473-86 pubmed publisher
    Prostacyclin and the prostacyclin receptor (IP) are implicated in mediating many of the atheroprotective effects of estrogen in both humans and in animal models but through unknown mechanisms...
  14. O Meara S, Kinsella B. The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor. Biochem J. 2005;386:177-89 pubmed
    Like Ras, farnesylation of the IP (prostacyclin receptor) is required for its efficient intracellular signalling, and hence the IP represents a potential target for inhibition by FTIs [FTase (farnesyl protein transferase) inhibitors]...
  15. Wikström K, Reid H, Hill M, English K, O Keeffe M, Kimbembe C, et al. Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase. Cell Signal. 2008;20:2332-46 pubmed publisher
    The human prostacyclin receptor (hIP) undergoes agonist-induced internalization but the mechanisms regulating its intracellular trafficking and/or recycling to the plasma membrane are poorly understood...
  16. Stitham J, Arehart E, Gleim S, Li N, Douville K, Hwa J. New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues. Br J Pharmacol. 2007;152:513-22 pubmed
    The human prostacyclin receptor (hIP), a G-protein coupled receptor (GPCR) expressed mainly on platelets and vascular smooth muscle cells, plays important protective roles in the cardiovascular system...
  17. Smyth E, Austin S, Fitzgerald G. Activation-dependent internalization of the human prostacyclin receptor. Adv Exp Med Biol. 2002;507:295-301 pubmed
  18. O Keeffe M, Reid H, Kinsella B. Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPase. Biochim Biophys Acta. 2008;1783:1914-28 pubmed publisher
    The human prostacyclin receptor (hIP) undergoes rapid agonist-induced internalization by largely unknown mechanism(s)...
  19. Wilson S, Smyth E. Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6. J Biol Chem. 2006;281:11780-6 pubmed
    ..Recycling of IP, but not IPSSLC, upon agonist removal was facilitated by overexpression of PDE6delta. Thus PDE6delta interacts specifically with IP to modulate receptor trafficking. ..
  20. Stitham J, Stojanovic A, Merenick B, O Hara K, Hwa J. The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling. J Biol Chem. 2003;278:4250-7 pubmed
    The human prostacyclin receptor is a seven-transmembrane alpha-helical G-protein coupled receptor, which plays important roles in both vascular smooth muscle relaxation as well as prevention of blood coagulation...
  21. Hayes J, Lawler O, Walsh M, Kinsella B. The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling. J Biol Chem. 1999;274:23707-18 pubmed
    The prostacyclin receptor (IP), a G protein-coupled receptor, mediates the actions of the prostanoid prostacyclin and its mimetics...
  22. Smyth E, Li W, Fitzgerald G. Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c. J Biol Chem. 1998;273:23258-66 pubmed
    Agonist-induced phosphorylation of an epitope-tagged prostacyclin receptor (HAhIP) is mediated primarily by PKC (Smyth, E. M., Nestor, P. V., and FitzGerald G. A. (1996) J. Biol. Chem. 271, 33698-33704)...
  23. Reid H, Mulvaney E, Turner E, Kinsella B. Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation. J Biol Chem. 2010;285:18709-26 pubmed publisher
    The human prostacyclin receptor (hIP) undergoes agonist-induced internalization and subsequent recyclization in slowly recycling endosomes involving its direct physical interaction with Rab11a...
  24. Stitham J, Arehart E, Gleim S, Douville K, MacKenzie T, Hwa J. Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR). Gene. 2007;396:180-7 pubmed
    The human prostacyclin receptor (hIP) has recently been recognized as an important seven transmembrane G-protein coupled receptor that plays critical roles in atheroprevention and cardioprotection...
  25. Giguere V, Gallant M, de Brum Fernandes A, Parent J. Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor. Eur J Pharmacol. 2004;494:11-22 pubmed
    ..The prostanoid IP receptor is a G-protein-coupled receptor...
  26. He T, Santhanam A, Lu T, d Uscio L, Katusic Z. Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels. J Cereb Blood Flow Metab. 2017;37:106-122 pubmed
    ..Our findings identified previously unrecognized role of IP-PPARδ signal transduction pathway in the production of sAPPα in cerebral microvasculature. ..
  27. Kim S, Kim Y, Park H, Jee Y, Kim S, Bahn J, et al. Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Pharmacogenet Genomics. 2007;17:295-304 pubmed
    ..015). These findings suggest that genetic polymorphisms in PTGER2, PTGER3, PTGER4, PTGIR, and TBXA2R play important roles in the pathogenesis of aspirin-intolerant asthma. ..
  28. Smyth E, Fitzgerald G. Human prostacyclin receptor. Vitam Horm. 2002;65:149-65 pubmed
    ..This article examines the current state of knowledge of the IP, its signaling and regulation, and its biological role in vivo and examines the possible existence of multiple PGI2 receptor sites.
  29. Zhang L, Huang G, Wu J, Ruan K. A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis. Biochemistry. 2005;44:11389-401 pubmed
    The first intracellular loop (iLP1, residues 39-51) of human prostacyclin receptor (IP) was proposed to be involved in signaling via its interaction with the Galphas protein...
  30. Hoeper M, McLaughlin V, Dalaan A, Satoh T, Galie N. Treatment of pulmonary hypertension. Lancet Respir Med. 2016;4:323-36 pubmed publisher
    ..phosphodiesterase-5 inhibitors, soluble guanylate cyclase stimulators, prostacyclin analogues, and prostacyclin receptor agonists...
  31. Eivers S, Kinsella B. Regulated expression of the prostacyclin receptor (IP) gene by androgens within the vasculature: Combined role for androgens and serum cholesterol. Biochim Biophys Acta. 2016;1859:1333-51 pubmed publisher
    ..This may explain, in part, some of the protective actions of androgens within the vasculature. ..
  32. Fortier I, Patry C, Lora M, Samadfan R, de Brum Fernandes A. Immunohistochemical localization of the prostacyclin receptor (IP) human bone. Prostaglandins Leukot Essent Fatty Acids. 2001;65:79-83 pubmed
    ....
  33. Grilo A, Sáez Rosas M, Santos Morano J, Sanchez E, Moreno Rey C, Real L, et al. Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. Pharmacogenet Genomics. 2011;21:10-7 pubmed publisher
    ..384 for protective combinations and 2.732≤OR≤7.216 for risk combinations). These results are consistent with the hypothesis that the mechanism of cough is related to the accumulation of bradykinin, substance P, and prostaglandins. ..
  34. Lo R, Wise H, Wong Y. Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK. Cell Signal. 2006;18:307-17 pubmed
    The ability of the human prostacyclin receptor (hIP) to regulate the activities of signal transducers and activators of transcription (STATs) has not yet been documented...
  35. Lau A, Lai H, Yeung B, Leung S, Tsang S, Wong Y, et al. Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3-dependent. Prostaglandins Leukot Essent Fatty Acids. 2012;86:119-26 pubmed publisher
    ....
  36. Fetalvero K, Shyu M, Nomikos A, Chiu Y, Wagner R, Powell R, et al. The prostacyclin receptor induces human vascular smooth muscle cell differentiation via the protein kinase A pathway. Am J Physiol Heart Circ Physiol. 2006;290:H1337-46 pubmed
    ..This provides important mechanistic insights into the induction of cardiovascular events with the use of selective COX-2 inhibitors. ..
  37. Jasińska Stroschein M, Orszulak Michalak D. Novel strategies for treatment of pulmonary arterial hypertension. Postepy Hig Med Dosw (Online). 2017;71:577-588 pubmed
    ..We focused on novel molecular mechanisms in PAH of recently approved: Guanylate cyclase stimulator and non-prostanoid IP receptor agonist...
  38. Kheirollahi M, Pourreza M, Khorvash F, Kazemi M, Amini G. A Report of a Novel Mutation in Human Prostacyclin Receptor Gene in Patients Affected with Migraine. Iran J Psychiatry. 2017;12:219-222 pubmed
    b>Objective: The human prostacyclin receptor gene encodes the human prostacyclin receptor, which is a part of the vasodilator system, during migraine attacks and almost certainly plays an important role in the mechanism of this ..
  39. Frey A, Ibrahim S, Gleim S, Hwa J, Smyth E. Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif. J Lipid Res. 2013;54:1678-90 pubmed publisher
    ..Heterodimerization of TPα with the functionally opposing prostacyclin receptor (IP) shifts TPα to signal via the IP-Gs cascade contributing to prostacyclin's restraint of TXA2 function...
  40. Ni F, So S, Cervantes V, Ruan K. A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor. FEBS J. 2008;275:128-37 pubmed
    ..To further test this hypothesis, another prostanoid receptor, the prostacyclin receptor (IP), which has opposite biological characteristics to that of TP, was used as a model for these studies...
  41. Wieland T, Michel M. Can a GDP-liganded G-protein be active?. Mol Pharmacol. 2005;68:559-62 pubmed
    ..We summarize here the evidence that GTP is necessary for effector activation by G-proteins and discuss potential implications and limitations of data to the contrary. ..
  42. Li R, Grosser T, Diamond S. Microfluidic whole blood testing of platelet response to pharmacological agents. Platelets. 2017;28:457-462 pubmed publisher
    ..platelet deposition under flow, as do NO donors and iloprost that target the guanylate cyclase and the prostacyclin receptor, respectively...
  43. Ibrahim S, McCartney A, Markosyan N, Smyth E. Heterodimerization with the prostacyclin receptor triggers thromboxane receptor relocation to lipid rafts. Arterioscler Thromb Vasc Biol. 2013;33:60-6 pubmed publisher
    ..We speculate that changes in IP and IPTP signaling after perturbation of membrane cholesterol may contribute to cardiovascular disease associated with hypercholesterolemia. ..
  44. Falcetti E, Hall S, Phillips P, Patel J, Morrell N, Haworth S, et al. Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2010;182:1161-70 pubmed publisher
    ..PPARγ may represent a previously unrecognized pathway by which these agents inhibit smooth muscle proliferation. ..
  45. Rauvala H, Peng H. HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts. Prog Neurobiol. 1997;52:127-44 pubmed
    ..In addition, a role in adult plasticity is suggested by studies on injury-induced and activity-dependent plasticity in rat hippocampus. ..
  46. Batchu S, Majumder S, Bowskill B, White K, Advani S, Brijmohan A, et al. Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms. Diabetes. 2016;65:1398-409 pubmed publisher
    ..Collectively, these observations describe a pharmacological strategy that posttranslationally modifies nephrin and the effects of this strategy in the pancreas and in the kidney. ..
  47. Khan F, Syeda P, Nartey M, Rahman M, Islam M, Nishimura K, et al. Stimulation of fat storage by prostacyclin and selective agonists of prostanoid IP receptor during the maturation phase of cultured adipocytes. Cytotechnology. 2016;68:2417-2429 pubmed
    ..during the maturation phase by the positive regulation of gene expression of PGI synthase and the prostanoid IP receptor. To clarify how prostacyclin regulates adipogenesis, we investigated the effects of prostacyclin and the ..
  48. Zhang L, Bastepe M, Juppner H, Ruan K. Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells. Arch Biochem Biophys. 2006;454:80-8 pubmed
    ..C-terminal domain of the Gs protein alpha subunit (Galphas Ct) and the first intracellular loop (iLP1) of prostacyclin receptor (IP) have been predicted to be involved in the receptor signaling mediated through the IP/Gs protein ..
  49. Mulvaney E, O Meara F, Khan A, O Connell D, Kinsella B. Identification of α-helix 4 (α4) of Rab11a as a novel Rab11-binding domain (RBD): Interaction of Rab11a with the Prostacyclin Receptor. Biochim Biophys Acta. 2017;1864:1819-1832 pubmed publisher
    ..In the case of the human prostacyclin receptor (hIP), it undergoes agonist-induced internalization and subsequent Rab11a-dependent recyclization ..
  50. Colombe L, Michelet J, Bernard B. Prostanoid receptors in anagen human hair follicles. Exp Dermatol. 2008;17:63-72 pubmed
    ..Although extracting a clear functional significance from this intricate network remains open challenge, FP labelling, i.e. could explain the biological effect of PGF(2alpha) on hair regrowth, by directly modulating DP function. ..
  51. Ogawa Y, Tanaka I, Inoue M, Yoshitake Y, Isse N, Nakagawa O, et al. Structural organization and chromosomal assignment of the human prostacyclin receptor gene. Genomics. 1995;27:142-8 pubmed
    b>Prostacyclin receptor is a member of the prostanoid receptor family in the G protein-coupled receptor superfamily with seven transmembrane domains...
  52. Zhang L, Wu J, Ruan K. Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein. Biochemistry. 2006;45:1734-44 pubmed
    ..residues 39-51) responsible for the interaction between the first intracellular loop (iLP1) of the human prostacyclin receptor (IP) and G alpha s protein have been identified [Zhang, L., Huang, G., Wu, J., and Ruan, K. H...
  53. Kahn N, Bauman W, Sinha A. Circulating heavy chain IgG, a pathological mediator for coronary artery disease, recognizes platelet surface receptors of both prostacyclin and insulin. Platelets. 2003;14:203-10 pubmed
    ..of the hormone binding, Kd1 = 2 x 10(-9) M) for the synthesis of nitric oxide but also blocked the prostacyclin receptor interaction in normal platelets...
  54. Plum J, Huang C, Grabensee B, Schror K, Meyer Kirchrath J. Prostacyclin enhances the expression of LPS/INF-gamma-induced nitric oxide synthase in human monocytes. Nephron. 2002;91:391-8 pubmed
    ..This study was designed to investigate the influence of prostacyclin receptor (IP receptor) activation on iNOS expression and NO formation in human peripheral blood monocytes...
  55. Sasaki Y, Takahashi T, Tanaka I, Nakamura K, Okuno Y, Nakagawa O, et al. Expression of prostacyclin receptor in human megakaryocytes. Blood. 1997;90:1039-46 pubmed
    ..Also, it was indicated that megakaryocytic maturation accompanies enhancement of PGI2-R expression. ..
  56. Coleman R, Smith W, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994;46:205-29 pubmed
  57. Duncan A, Anderson L, Funk C, Abramovitz M, Adam M. Chromosomal localization of the human prostanoid receptor gene family. Genomics. 1995;25:740-2 pubmed
    ..that encode the PGE2 receptor subtypes (PTGER1, PTGER2, and PTGER3), the PGF2 alpha receptor (PTGFR), the PGI2 receptor (PTGIR), and the TXA2 receptor (TBXA2R) using in situ hybridization...
  58. Donnellan P, Kimbembe C, Reid H, Kinsella B. Identification of a novel endoplasmic reticulum export motif within the eighth α-helical domain (α-H8) of the human prostacyclin receptor. Biochim Biophys Acta. 2011;1808:1202-18 pubmed publisher
    The human prostacyclin receptor (hIP) undergoes agonist-dependent trafficking involving a direct interaction with Rab11a GTPase...
  59. Muto A, Nishibe T, Miyauchi Y, Kondo Y, Yamamoto Y, Dardik A, et al. Prostaglandin receptors EP2 and IP are detectable in atherosclerotic arteries and plaques. Int Angiol. 2010;29:43-8 pubmed
    ..These results suggest that receptor-selective PG agonists specifically target atherosclerotic arteries and therefore, may find potential application in the pharmacological management of patients with ASO. ..
  60. Liu W, Li H, Zhang X, Wen D, Yu F, Yang S, et al. Prostaglandin I2-IP signalling regulates human Th17 and Treg cell differentiation. Prostaglandins Leukot Essent Fatty Acids. 2013;89:335-44 pubmed publisher
    ..Together with previous results, these data suggest that prostanoids play an important role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis. ..
  61. Nobles M, Benians A, Tinker A. Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proc Natl Acad Sci U S A. 2005;102:18706-11 pubmed
    ..In contrast, the predominantly Gs-coupled prostacyclin receptor interacted with Gs, but there was little interaction between the prostacyclin receptor and Go...
  62. Kömhoff M, Lesener B, Nakao K, Seyberth H, Nüsing R. Localization of the prostacyclin receptor in human kidney. Kidney Int. 1998;54:1899-908 pubmed
    ..into the network of prostacyclin signal transduction, we analyzed the intrarenal distribution of the prostacyclin receptor (IP receptor) in adult human kidney...