PROS1

Summary

Gene Symbol: PROS1
Description: protein S
Alias: PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6, vitamin K-dependent protein S, protein S (alpha), protein Sa, vitamin K-dependent plasma protein S
Species: human
Products:     PROS1

Top Publications

  1. Schmidel D, Tatro A, Phelps L, Tomczak J, Long G. Organization of the human protein S genes. Biochemistry. 1990;29:7845-52 pubmed
    ..Comparison of DNA sequences for the two genes reveals 97% identity for coding and 3' noncoding, and 95.4% for intronic regions, suggesting divergence of the two genes is a relatively recent event. ..
  2. Espinosa Parrilla Y, Morell M, Souto J, Tirado I, Fontcuberta J, Estivill X, et al. Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency. Hum Mutat. 1999;14:30-9 pubmed
    DNA sequence analysis of the protein S gene (PROS1) in 22 Spanish probands with type I or III PS deficiency, has allowed the identification of 10 different mutations and 2 new sequence variants in 15 probands...
  3. Tatewaki H, Tsuda H, Kanaji T, Yokoyama K, Hamasaki N. Characterization of the human protein S gene promoter: a possible role of transcription factors Sp1 and HNF3 in liver. Thromb Haemost. 2003;90:1029-39 pubmed
  4. Johansson A, Hillarp A, Sall T, Zöller B, Dahlback B, Hallden C. Large deletions of the PROS1 gene in a large fraction of mutation-negative patients with protein S deficiency. Thromb Haemost. 2005;94:951-7 pubmed
    Protein S deficiency is an autosomal dominant disorder that results from mutations in the PROS1 gene. Conventional mutation detection techniques fail to detect a pathogenic PROS1 mutation in approximately 50% of cases...
  5. De Wolf C, Cupers R, Bertina R, Vos H. The constitutive expression of anticoagulant protein S is regulated through multiple binding sites for Sp1 and Sp3 transcription factors in the protein S gene promoter. J Biol Chem. 2006;281:17635-43 pubmed
    ..Their relevance was investigated using site-directed mutagenesis. ..
  6. Garcia de Frutos P, Fuentes Prior P, Hurtado B, Sala N. Molecular basis of protein S deficiency. Thromb Haemost. 2007;98:543-56 pubmed
    ..Almost two-hundred mutations have been characterised in PROS1, and approximately 30% of them have been characterised in vitro, clarifying the mechanisms leading to PSD...
  7. Yin T, Takeshita S, Sato Y, Sakata T, Shin Y, Honda S, et al. A large deletion of the PROS1 gene in a deep vein thrombosis patient with protein S deficiency. Thromb Haemost. 2007;98:783-9 pubmed
    Inherited deficiency of protein S encoded by the PROS1 gene constitutes an important risk factor for deep vein thrombosis (DVT)...
  8. Ploos van Amstel H, Reitsma P, van der Logt C, Bertina R. Intron-exon organization of the active human protein S gene PS alpha and its pseudogene PS beta: duplication and silencing during primate evolution. Biochemistry. 1990;29:7853-61 pubmed
    ..5% homology. Southern analysis of primate DNA showed that the duplication of the ancestral protein S gene has occurred after the branching of the orangutan from the African apes.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  9. Dahlback B, Stenflo J. High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein. Proc Natl Acad Sci U S A. 1981;78:2512-6 pubmed
    ..Furthermore, there is an equilibrium between free and bound protein S in plasma. The role of protein S in the complex is unknown. ..

More Information

Publications146 found, 100 shown here

  1. Chang C, Tung Y, Lin Y, Liao C, Chiu C, Tung T, et al. Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome-A Preliminary Open Study. J Clin Med. 2019;8: pubmed publisher
    ..C1RL), complement component C6 (C6), complement component C8 gamma chain (C8G), and vitamin K-dependent protein S (PROS) were significantly different between the CRPS and CR groups...
  2. Nakayama T, Mizutani K, Hanamura I, Kato H, Takami A, Takeshita K, et al. Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. J Dermatol. 2017;44:198-201 pubmed publisher
    ..Analysis of protein S-alpha gene revealed 155 Lys>Glu mutation in exon VI, which was reported in 1994 and named as protein S Tokushima. Thus, we conclude that protein S deficiency could contribute to LV. ..
  3. Wypasek E, Karpiński M, Alhenc Gelas M, Undas A. Venous thromboembolism associated with protein S deficiency due to Arg451* mutation in PROS1 gene: a case report and a literature review. J Genet. 2017;96:1047-1051 pubmed
    ..Here, we report the first Polish case with PS deficiency caused by the p.Arg451* in the PROS1 gene detected in a 21-year-old man with trauma-induced venous thromboembolism...
  4. Michaelsen F, Saeed M, Schwarzkopf J, Efferth T. Activity of Artemisia annua and artemisinin derivatives, in prostate carcinoma. Phytomedicine. 2015;22:1223-31 pubmed publisher
    ..A patient with prostate carcinoma (pT3bN1M1, Gleason score 8 (4+4)) presented with a prostate specific antigen (PSA) level >800 µg/l...
  5. Chang W, Tsai Y, Wang J, Chen H, Yang W, Lee C. Sex hormones and oxidative stress mediated phthalate-induced effects in prostatic enlargement. Environ Int. 2019;126:184-192 pubmed publisher
    ..ratios, inducible nitric oxide synthetase (iNOS), 8-hydroxy-2'-deoxyguanosine (8-OHdG), prostate specific antigen (PSA), and prostate volume (PV) (p < 0.05)...
  6. Nickerson M, Das S, Im K, Turan S, Berndt S, Li H, et al. TET2 binds the androgen receptor and loss is associated with prostate cancer. Oncogene. 2017;36:2172-2183 pubmed publisher
    ..AR) and AR-coactivator proteins in LNCaP cell extracts, and TET2 KD increases prostate-specific antigen (KLK3/PSA) expression. Published data reveal TET2 binding sites and hydroxymethylcytosine proximal to KLK3...
  7. Traish A, Haider K, Doros G, Haider A. Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction. Horm Mol Biol Clin Investig. 2017;30: pubmed publisher
    ..significant improvements in LUTS, as assessed by reduction in prostate volume, IPSS and prostate specific antigen (PSA)...
  8. Kawamoto Y, Kondo H, Hasegawa M, Kurimoto C, Ishii Y, Kato C, et al. Inhibition of mast cell degranulation by melanin. Biochem Pharmacol. 2019;163:178-193 pubmed publisher
    ..In vivo experiments using passive systemic anaphylaxis (PSA) and passive cutaneous anaphylaxis (PCA) mouse models demonstrated that oral administration of melanin accelerated ..
  9. Du F, Fan J, Wang T, Wu Y, Grierson D, Gao Z, et al. Identification of differentially expressed genes in flower, leaf and bulb scale of Lilium oriental hybrid 'Sorbonne' and putative control network for scent genes. BMC Genomics. 2017;18:899 pubmed publisher
    ..starch branching enzyme (SBE), ADP-glucose pyrophosphorylase (AGP) and?-amylase (BAM) and photosynthesis genes (Psa, Psb, Pet and ATP) were also identified...
  10. Wimalawansa S. The role of ions, heavy metals, fluoride, and agrochemicals: critical evaluation of potential aetiological factors of chronic kidney disease of multifactorial origin (CKDmfo/CKDu) and recommendations for its eradication. Environ Geochem Health. 2016;38:639-78 pubmed publisher
    ..This article evaluates pros and cons of each hypothesis and highlights the importance of among others, providing clean water to all affected ..
  11. de Andrade A, Arruda R, Torres M, Pieri N, Leite T, Celeghini E, et al. Nitric oxide in frozen-thawed equine sperm: Effects on motility, membrane integrity and sperm capacitation. Anim Reprod Sci. 2018;: pubmed publisher
    ..and other analyses [plasma and acrosomal membranes used the propidium iodide (PI) and Pisum sativum agglutinin (PSA), detection of tyrosine residues phosphorylation in the membrane (F0426), nitric oxide (DAF-2/DA), lipid ..
  12. Ub Wijerathne C, Park H, Jeong H, Song J, Moon O, Seo Y, et al. Quisqualis indica Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis. Biol Pharm Bull. 2017;40:2125-2133 pubmed publisher
    ..were treated with QI plus testosterone propionate (TP), and androgen receptor (AR) and prostate specific antigen (PSA) expression levels were assessed by Western blotting...
  13. Chen K, Sung S, Lin Y, Hsieh C, Shen K, Peng C, et al. Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise-evidences revealed by the rat model. BMC Urol. 2015;15:113 pubmed publisher
    ..As contrast, EX upregulated insulin, IGF, Ts, NO, 5αRd, AR, and DHT, and substantially reduced PSA. In BPH + DM + EX, EX maintained BW at a subnormal level, slightly suppressed prostate stromal inflammation,..
  14. Gómez Martín A, Martinez Gonzalez L, Puche Sanz I, Cozar J, Lorente J, Hernandez A, et al. GSTM1 gene expression and copy number variation in prostate cancer patients-Effect of chemical exposures and physical activity. Urol Oncol. 2019;37:290.e9-290.e15 pubmed publisher
    ..Individuals were classified in each group based on histological analysis of tissue biopsy, along with data on PSA level, Gleason score and T stage in patients with biopsies positive for CaP...
  15. Lopez L, Steiner M, Grimes D, Hilgenberg D, Schulz K. Strategies for communicating contraceptive effectiveness. Cochrane Database Syst Rev. 2013;:CD006964 pubmed publisher
    Knowledge of contraceptive effectiveness is crucial to making an informed choice. The consumer has to comprehend the pros and cons of the contraceptive methods being considered...
  16. Takuwa H, Tsuji W, Shintaku M, Yotsumoto F. Hormone signaling via androgen receptor affects breast cancer and prostate cancer in a male patient: A case report. BMC Cancer. 2018;18:1282 pubmed publisher
    ..revealed that the patient had cT3N0M0, stage III primary prostate cancer with a prostate-specific antigen (PSA) level of 40.5 ng/mL. Germline mutations in the BRCA1 and BRCA2 genes were not tested...
  17. Smirnova S, Barilo A, Smolnikova M. [Hepatobiliary System Diseases as the Predictors of Psoriasis Progression]. Vestn Ross Akad Med Nauk. 2016;:102-8 pubmed
    ..matched by sex and age: Group 1--patients with psoriasis (PS, n = 77), group 2--patients with psoriatic arthritis (PsA, n = 98), group 3--control...
  18. Detering M, Steels E, Koyyalamudi S, Allifranchini E, Bocchietto E, Vitetta L. Ageratum conyzoides L. inhibits 5-alpha-reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study. Biofactors. 2017;: pubmed publisher
    ..globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview ..
  19. Demark Wahnefried W, Nix J, Hunter G, Rais Bahrami S, Desmond R, Chacko B, et al. Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy. BMC Cancer. 2016;16:61 pubmed publisher
    ..activated caspase-3, insulin and androgen receptors, VEGF, TNFβ, NFκB, and 4E-BP1), circulating biomarkers (PSA, insulin, glucose, VEGF, TNFβ, leptin, SHBG, and testosterone), lymphocytic gene expression of corresponding ..
  20. Seoane Mato D, Sánchez Piedra C, Silva Fernández L, Sivera F, Blanco F, Perez Ruiz F, et al. Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology. Reumatol Clin. 2019;15:90-96 pubmed publisher
    ..The aim of this study is to estimate the prevalence of rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), osteoarthritis (knee, ..
  21. Abdel Daim M, Abushouk A, Reggi R, Yarla N, Palmery M, Peluso I. Association of antioxidant nutraceuticals and acetaminophen (paracetamol): Friend or foe?. J Food Drug Anal. 2018;26:S78-S87 pubmed publisher
    ..The aim of this review is to discuss the pros and cons of the association of antioxidant nutraceuticals and APAP by reviewing the in vivo evidence, with ..
  22. Alonge S, Melandri M, Aiudi G, Lacalandra G. Advances in Prostatic Diagnostics in Dogs: The Role of Canine Prostatic Specific Esterase in the Early Diagnosis of Prostatic Disorders. Top Companion Anim Med. 2018;33:105-108 pubmed publisher
    ..biomarker to be included in a prostate health screening program, following the model of prostate-specific antigen (PSA) in human medicine...
  23. Henning S, Galet C, Gollapudi K, Byrd J, Liang P, Li Z, et al. Phase II prospective randomized trial of weight loss prior to radical prostatectomy. Prostate Cancer Prostatic Dis. 2018;21:212-220 pubmed publisher
    ..radical prostatectomy tissue, body weight, body mass index (BMI), waist to hip ratio, body composition, and serum PSA, insulin, triglyceride, cholesterol, testosterone, estradiol, leptin, adiponectin, interleukin 6, interleukin 8, ..
  24. Schöfer H. [Male circumcision from an infectiological point of view]. Hautarzt. 2015;66:30-7 pubmed publisher
    ..How male circumcision is assessed in terms of infectiology (pros and cons)? Electronic databases were searched for articles about the infection risks of foreskin surgery, and the ..
  25. Malemud C. Matrix Metalloproteinases and Synovial Joint Pathology. Prog Mol Biol Transl Sci. 2017;148:305-325 pubmed publisher
    ..in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), and the spondyloarthropathies...
  26. Fujio K, Watanabe M, Ueki H, Li S, Kinoshita R, Ochiai K, et al. A vaccine strategy with multiple prostatic acid phosphatase-fused cytokines for prostate cancer treatment. Oncol Rep. 2015;33:1585-92 pubmed publisher
    ..effects of multiple PAP-fused cytokines in a mouse prostate cancer model bearing prostate-specific antigen (PSA)- and PAP-expressing tumors...
  27. Gerber L, Estep M, Stepanova M, Escheik C, Weinstein A, Younossi Z. Effects of Viral Eradication With Ledipasvir and Sofosbuvir, With or Without Ribavirin, on Measures of Fatigue in Patients With Chronic Hepatitis C Virus Infection. Clin Gastroenterol Hepatol. 2016;14:156-64.e3 pubmed publisher
    ..Data were collected on fatigue-related patient-reported outcomes (PROs) and assessed by using the Functional Assessment of Cancer Therapy-Fatigue scoring system and the Vitality subscale ..
  28. Zhang W, Zhao R, Li X, Cui X, Zhao Z, Mao Y, et al. Effect of Yi-nao-jie-yu decoction on ?-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety. Neuropsychiatr Dis Treat. 2016;12:2827-2837 pubmed
    ..Chinese medicine and has been recently used as an important new therapeutic agent in poststroke anxiety (PSA)...
  29. Fonager R, Zacho H, Langkilde N, Petersen L. (18)F-fluoride positron emission tomography/computed tomography and bone scintigraphy for diagnosis of bone metastases in newly diagnosed, high-risk prostate cancer patients: study protocol for a multicentre, diagnostic test accuracy study. BMC Cancer. 2016;16:10 pubmed publisher
    ..Eligibility criteria comprise the following: 1) biopsy-proven prostate cancer, 2) PSA ≥ 50 ng/ml (equals a prevalence of bone metastasis of ≈ 50% in the study population on bone ..
  30. Żołnierczyk A, Mączka W, Grabarczyk M, Wińska K, Woźniak E, Anioł M. Isoxanthohumol--Biologically active hop flavonoid. Fitoterapia. 2015;103:71-82 pubmed publisher
    ..It also inhibits the production of prostate specific antigen (PSA)...
  31. Röhle R, Gehrmann K, Szarras Czapnik M, Claahsen van der Grinten H, Pienkowski C, Bouvattier C, et al. Participation of adults with disorders/differences of sex development (DSD) in the clinical study dsd-LIFE: design, methodology, recruitment, data quality and study population. BMC Endocr Disord. 2017;17:52 pubmed publisher
    ..Recruitment of individuals with XY DSD conditions proved to be more difficult. The data collection of PROs resulted in high data quality...
  32. Shoji S, Ukimura O, de Castro Abreu A, Marien A, Matsugasumi T, Bahn D, et al. Image-based monitoring of targeted biopsy-proven prostate cancer on active surveillance: 11-year experience. World J Urol. 2016;34:221-7 pubmed publisher
    ..Clinical variables (median) included age (61 years), clinical stage (T1c, 42;T2, 8), PSA (4.6 ng/ml), and Gleason score (3 + 3, n = 41;3 + 4, n = 9)...
  33. Yan F, Xu K, Yao X, Li Y. Fuzzy Bayesian Network-Bow-Tie Analysis of Gas Leakage during Biomass Gasification. PLoS ONE. 2016;11:e0160045 pubmed publisher
    ..Therefore, probabilistic safety assessment (PSA) is necessary for biomass gasification system...
  34. Fossati N, Karnes R, Colicchia M, Boorjian S, Bossi A, Seisen T, et al. Impact of Early Salvage Radiation Therapy in Patients with Persistently Elevated or Rising Prostate-specific Antigen After Radical Prostatectomy. Eur Urol. 2017;: pubmed publisher
    ..Patients received SRT for either prostate-specific antigen (PSA) rising, or PSA persistence after RP that was defined as PSA level ≥0.1 ng/ml at 1 mo after surgery...
  35. Lubrano E, Perrotta F. Beyond TNF Inhibitors: New Pathways and Emerging Treatments for Psoriatic Arthritis. Drugs. 2016;76:663-73 pubmed publisher
    Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by psoriasis, synovitis, enthesitis, spondylitis and association with other extra-articular manifestations...
  36. Fu A, Tsai H, Haque R, Ulcickas Yood M, Van Den Eeden S, Cassidy Bushrow A, et al. Use of androgen deprivation therapy as salvage treatment after primary therapy for clinically localized prostate cancer. World J Urol. 2016;34:1611-1619 pubmed
    ..relative to age 35-59 for primary prostatectomy or radiotherapy, respectively), were African-American, had a short PSA doubling time, had a higher pre-treatment risk of progression, had more comorbidities, and received adjuvant ADT ..
  37. Schwartz C, Powell V, Rapkin B. When global rating of change contradicts observed change: Examining appraisal processes underlying paradoxical responses over time. Qual Life Res. 2017;26:847-857 pubmed publisher
    ..GRC scores were more strongly associated with appraisal processes than with change in patient-reported outcomes (PROs) (R 2 = 11 and 2 %, respectively)...
  38. Mostaghel E, Cho E, Zhang A, Alyamani M, Kaipainen A, Green S, et al. Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer. Clin Cancer Res. 2017;23:4592-4601 pubmed publisher
    ..Serum PSA and tumor volumes were higher in men with undetectable versus detectable tissue abiraterone at prostatectomy (..
  39. Mayo N, Figueiredo S, Ahmed S, Bartlett S. Montreal Accord on Patient-Reported Outcomes (PROs) use series - Paper 2: terminology proposed to measure what matters in health. J Clin Epidemiol. 2017;89:119-124 pubmed publisher
    ..Now is the time to "talk the talk" as part of larger coordinated efforts within and across countries to identify and measure what matters most in health. ..
  40. Stokem K, Zuckerman J, Nicolau D, Wungwattana M, Sears E. Use of ceftolozane-tazobactam in a cystic fibrosis patient with multidrug-resistant pseudomonas infection and renal insufficiency. Respir Med Case Rep. 2018;23:8-9 pubmed publisher
    ..CF), malnutrition, chronic kidney disease, and multi-drug resistant Pseudomonas aeruginosa infection (MDR PSA)...
  41. Hainmann I, Korinthenberg R, Oldenburg J, Pavlova A, Mader I, Zieger B. Compound heterozygosity of the protein S-gene as a cause of severe cerebral sinovenous thrombosis in a 7-year-old child. Klin Padiatr. 2010;222:194-5 pubmed publisher
    ..In case of thrombosis analysis of protein S is recommended. Low levels of protein S should be further investigated by molecular diagnostics. ..
  42. Giorgianni A, Pellegrino C, Minotto R, Mercuri A, Baruzzi F, Cantoni A, et al. Flow-diverter stenting in post-traumatic pseudoaneurysm of cavernous internal carotid artery with epistaxis. Interv Neuroradiol. 2015;21:325-8 pubmed publisher
    ..The trauma occasioned pseudoaneurysm (PSA) from intracavernous C4 segment of left internal carotid artery (ICA) protruding in the sphenoidal sinus...
  43. Rezaee M, Ward C, Odom B, Pollock M. Prostate cancer screening practices and diagnoses in patients age 50 and older, Southeastern Michigan, pre/post 2012. Prev Med. 2016;82:73-6 pubmed publisher
    ..S. Preventive Services Task Force (USPSTF) recommendation against the use of prostate specific antigen (PSA) screening for prostate cancer have been limited...
  44. Egeter J, Hüfner K, Sztankay M, Holzner B, Sperner Unterweger B. Implementation of an electronic routine outcome monitoring at an inpatient unit for psychosomatic medicine. J Psychosom Res. 2018;105:64-71 pubmed publisher
    Patient-reported outcomes (PROs) can be part of an electronic routine outcome monitoring (eROM). eROM can improve patient involvement, treatment outcomes and simplify scientific data assessment...
  45. Hoskins J, Norman D, Beckmann R, Long G. Cloning and characterization of human liver cDNA encoding a protein S precursor. Proc Natl Acad Sci U S A. 1987;84:349-53 pubmed
  46. Fan D, Ren X, Wang H, Wu D, Zhao D, Chen Y, et al. Ultrasensitive sandwich-type photoelectrochemical immunosensor based on CdSe sensitized La-TiO2 matrix and signal amplification of polystyrene@Ab2 composites. Biosens Bioelectron. 2017;87:593-599 pubmed publisher
    ..was fabricated using signal amplification strategy for the quantitative detection of the prostate specific antigen (PSA)...
  47. Shen J, Wang L, Taylor J. Estimation of the optimal regime in treatment of prostate cancer recurrence from observational data using flexible weighting models. Biometrics. 2017;73:635-645 pubmed publisher
    ..A multi-center prostate cancer observational study has provided us data on longitudinal prostate specific antigen (PSA) measurements, time-varying salvage treatment, and cancer recurrence time...
  48. Gayet M, Mannaerts C, Nieboer D, Beerlage H, Wijkstra H, Mulders P, et al. Prediction of Prostate Cancer: External Validation of the ERSPC Risk Calculator in a Contemporary Dutch Clinical Cohort. Eur Urol Focus. 2018;4:228-234 pubmed publisher
    ..Patients were included if they met ERSPC RC requirements of age (50-80 yr), prostate-specific antigen (PSA) (0.4-50 ng/ml), and prostate volume (10-150ml)...
  49. Yu Q, Wu Y, Liu Z, Lei S, Li G, Ye B. Novel electrochemical biosensor based on cationic peptide modified hemin/G-quadruples enhanced peroxidase-like activity. Biosens Bioelectron. 2018;107:178-183 pubmed publisher
    ..activity of hemin/G-quadruplex, the peptide could also be induced and cleaved by prostate specific antigen (PSA). It was the first report on peptide-DNAzyme conjugates in application of the peptide biosensor...
  50. Andeweg C, Berg R, Staal J, Ten Broek R, van Goor H. Patient-reported Outcomes After Conservative or Surgical Management of Recurrent and Chronic Complaints of Diverticulitis: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2016;14:183-90 pubmed publisher
    ..We conducted a systematic review and meta-analysis of quality of life (QOL) and other patient-reported outcomes (PROs) after conservative vs surgical treatment of uncomplicated diverticulitis...
  51. Hegazy M, Mahmood R, Al Otaibi M, Khalil E. Hypofractionated Volumetric Modulated Arc Radiotherapy with simultaneous Elective Nodal Irradiation is feasible in prostate cancer patients: A single institution experience. J Egypt Natl Canc Inst. 2016;28:101-10 pubmed publisher
    ..09) with a median FU period of 34months (range: 14-53months). Gleason Score (p=0.02), and pretreatment PSA (p=0...
  52. Michaud L, Touijer K. [Focus on molecular imaging in prostate cancer]. Prog Urol. 2016;26:619-627 pubmed publisher
    ..The choline has changed the recurrence of prostate cancer but is not effective for recurrence with low PSA, furthermore its sensitivity is low for the detection of lymph nodes metastasis in initial disease...
  53. Song W, Kwon G, Kim J, Lim J, Jeon H, Il Seo S, et al. Immunohistochemical staining of ERG and SOX9 as potential biomarkers of docetaxel response in patients with metastatic castration-resistant prostate cancer. Oncotarget. 2016;7:83735-83743 pubmed publisher
    ..Treatment response was assessed by prostate specific antigen (PSA) response rate, PSA progression-free survival (PSA-PFS), clinical/radiologic PFS (C/R-PFS) and overall survival (OS)..
  54. Citterio G, Reni M, Gatta G, Ferreri A. Primary central nervous system lymphoma. Crit Rev Oncol Hematol. 2017;113:97-110 pubmed publisher
    ..High-dose chemotherapy supported by autologous stem-cell transplantation is increasingly used as an effective method aimed to control microscopic disease, and the pros and contras of this approach are outlined.
  55. Wassberg C, Lubberink M, Sorensen J, Johansson S. Repeatability of quantitative parameters of 18F-fluoride PET/CT and biochemical tumour and specific bone remodelling markers in prostate cancer bone metastases. EJNMMI Res. 2017;7:42 pubmed publisher
    ..Blood/serum biochemical bone turnover markers obtained at the time of each PET were PSA, ALP, S-osteocalcin, S-beta-CTx, 1CTP and BAP...
  56. Lo T, Beamis J, Villanueva A, Gray A, Wu T. Intraluminal brachytherapy for malignant endobronchial tumors: an update on low-dose rate versus high-dose rate radiation therapy. Clin Lung Cancer. 2001;3:65-8; discussion 69-70 pubmed
    ..patient convenience, and radiation protection, our experience with both modalities permits assessment of the pros and cons of each technique. In November 1991, our HDR remote afterloading brachytherapy unit became operational...
  57. Hicks C, Lum Y. Patient-reported outcome measures in vascular surgery. Semin Vasc Surg. 2015;28:122-33 pubmed publisher
    Patient-reported outcomes (PROs) after vascular surgery are becoming increasingly important in the current era of health care reform...
  58. Heijnsdijk E, Denham D, de Koning H. The Cost-Effectiveness of Prostate Cancer Detection with the Use of Prostate Health Index. Value Health. 2016;19:153-7 pubmed publisher
    Clinical trial results suggested that prostate-specific antigen (PSA) screening can reduce prostate cancer mortality. Nevertheless, because the specificity of the PSA test for cancer detection is low, it leads to many negative biopsies...
  59. Fuentes Pastor J, Pellejero P, Ortiz I, Ramirez Backhaus M, de Gracia A, Marrugo C, et al. Association between late-onset hypogonadism syndrome plus metabolic syndrome and prostate cancer and its aggressiveness. Actas Urol Esp. 2016;40:440-5 pubmed publisher
    ..and PC and its aggressiveness on the other, as well as the usefulness of the TT to prostate specific antigen (TT/PSA) ratio in the PC diagnosis. The patient's median age was 65 years. Metabolic syndrome is not associated with PC (39...
  60. Antonarakis E, Kibel A, Yu E, Karsh L, Elfiky A, Shore N, et al. Sequencing of Sipuleucel-T and Androgen Deprivation Therapy in Men with Hormone-Sensitive Biochemically Recurrent Prostate Cancer: A Phase II Randomized Trial. Clin Cancer Res. 2017;23:2451-2459 pubmed publisher
    ..b>Experimental Design: Men with BRPC following prostatectomy and/or radiotherapy, a PSA doubling time ≤12 months, and no metastasis were enrolled...
  61. Hester L, Poole C, Suarez E, Der J, Anderson O, Almon K, et al. Publication of comparative effectiveness research has not increased in high-impact medical journals, 2004-2013. J Clin Epidemiol. 2017;84:185-187 pubmed publisher
    ..this study sought to describe patterns of comparative effectiveness research (CER) and patient-reported outcomes (PROs) in pharmacologic intervention studies published in widely read medical journals from 2004-2013...
  62. Morgia G, Urzì D, Russo G. [5ARI and PSA: evidences]. Urologia. 2014;81 Suppl 24:4-11 pubmed publisher
    ..One of the most debated topics is the interpretation of the variation of the serum PSA during treatment with 5ARIs...
  63. Leeb B, Brezinschek H, Rintelen B. RADAI-5 and electronic monitoring tools. Clin Exp Rheumatol. 2016;34:S5-S10 pubmed
    ..These tools collect patient-recorded outcomes (PROs) data, through which physicians can monitor the course of the individual disease...
  64. Alcay S, Toker M, Onder N, Gökçe E. Royal jelly supplemented soybean lecithin-based extenders improve post-thaw quality and incubation resilience of goat spermatozoa. Cryobiology. 2017;74:81-85 pubmed publisher
    ..membrane integrity using hypoosmotic swelling test (HOST) damaged acrosome using FITC-Pisum sativum agglutinin (PSA-FITC) and DNA integrity using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)...
  65. Khan N, Jhung S. Adsorptive removal and separation of chemicals with metal-organic frameworks: Contribution of ?-complexation. J Hazard Mater. 2017;325:198-213 pubmed publisher
    ..Details of the ?-complexation, including mechanism, pros/cons, applications, and efficient ways to form the complex, are discussed systematically...
  66. Ahmad R, Nicora C, Shukla A, Smith R, Qian W, Liu A. An efficient method for native protein purification in the selected range from prostate cancer tissue digests. Chin Clin Oncol. 2016;5:78 pubmed publisher
    ..The presence of cancer-specific anterior gradient 2 (AGR2) and absence of prostate-specific antigen (PSA)/KLK3 were confirmed by Western blotting...
  67. Basch E, Spertus J, Dudley R, Wu A, Chuahan C, Cohen P, et al. Methods for Developing Patient-Reported Outcome-Based Performance Measures (PRO-PMs). Value Health. 2015;18:493-504 pubmed publisher
    ..Literature review focused on programs using PROs to assess performance and on PRO guidance documents...
  68. Gandaglia G, Cozzarini C, Mottrie A, Bossi A, Fossati N, Montorsi F, et al. The Role of Radiotherapy After Radical Prostatectomy in Patients with Prostate Cancer. Curr Oncol Rep. 2015;17:53 pubmed publisher
    ..studies demonstrated that this approach leads to excellent outcomes if administered at the earliest sign of PSA recurrence...
  69. Qi W, Morales C, Cooke L, JOHNSON B, Somer B, Mahadevan D. Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer. Oncotarget. 2015;6:41976-87 pubmed publisher
    ..Mechanistically, LNCaP 'MDV-R' cells had significantly reduced AR, loss of PSA and increase Akt activity in contrast with LNCaP 'PF-R' cells...
  70. Modi D, Hwang C, Mamdani H, Kim S, Gayar H, Vaishampayan U, et al. Radium-223 in Heavily Pretreated Metastatic Castrate-Resistant Prostate Cancer. Clin Genitourin Cancer. 2016;14:373-380.e2 pubmed publisher
    ..Trend of PSA, radiographic changes, and association of biochemical and clinical variables with PSA trend were measured...
  71. Valentine J, Chen L, Perregaux E, Weyant K, Rosenthal J, Heiss C, et al. Immunization with Outer Membrane Vesicles Displaying Designer Glycotopes Yields Class-Switched, Glycan-Specific Antibodies. Cell Chem Biol. 2016;23:655-65 pubmed publisher
    ..This approach involved heterologous expression of two clinically important glycans, namely polysialic acid (PSA) and Thomsen-Friedenreich antigen (T antigen) in hypervesiculating strains of non-pathogenic Escherichia coli...
  72. Dejima T, Imada K, Takeuchi A, Shiota M, Leong J, Tombe T, et al. Suppression of LIM and SH3 Domain Protein 1 (LASP1) Negatively Regulated by Androgen Receptor Delays Castration Resistant Prostate Cancer Progression. Prostate. 2017;77:309-320 pubmed publisher
    LIM and SH3 domain protein 1 (LASP1) has been implicated in several human malignancies and has been shown to predict PSA recurrence in prostate cancer...
  73. Xu X, Zhang A, Li N, Li P, Zhang F. Concentration-Dependent Diversifcation Effects of Free Cholesterol Loading on Macrophage Viability and Polarization. Cell Physiol Biochem. 2015;37:419-431 pubmed publisher
    ..diversification effects on macrophage viability, polarization, apoptosis and inflammatory cytokine secretions, thereby reconciling the pros and cons of free cholesterol buildup in macrophages to the pathophysiology of atherosclerosis.
  74. Harle C, Marlow N, Schmidt S, Shuster J, Listhaus A, Fillingim R, et al. The effect of EHR-integrated patient-reported outcomes on satisfaction with chronic pain care. Am J Manag Care. 2016;22:e403-e408 pubmed
    ..The objective of this study was to assess whether integrating patient-reported outcomes (PROs) data in an electronic health record (EHR) affects provider and patient satisfaction with chronic noncancer pain ..
  75. Tang M, Garcia S, Malvar Fernandez B, Gerlag D, Tak P, Reedquist K. Rheumatoid arthritis and psoriatic arthritis synovial fluids stimulate prolactin production by macrophages. J Leukoc Biol. 2017;102:897-904 pubmed publisher
    ..fluid (SF) and peripheral blood of patients with rheumatoid arthritis (RA, n = 19), psoriatic arthritis (PsA, n = 11), and gout (n = 11)...
  76. Weight C, Narayan V, Smith D, Kim S, Karnes R. The Effects of Population-based Prostate-specific Antigen Screening Beginning at Age 40. Urology. 2017;110:127-133 pubmed publisher
    ..men in their 40s, given the paucity of prospective data evaluating the consequences of prostate-specific antigen (PSA) testing in younger men for CaP...
  77. Zhao Z, Fan J, Liu Y, de la Rosette J, Zeng G. Percutaneous nephrolithotomy: position, position, position!. Urolithiasis. 2018;46:79-86 pubmed publisher
    ..position, the present review describes the position-related general basis, and provides a literature review of the pros and cons of various positions from a surgical and anaesthetic point of view...
  78. Takahashi Y, Uryuhara Y, Inoue M, Okamoto S, Kashihara H, Kito K, et al. [Awareness survey of Healthcare Number System pros and cons according to medical doctors in Japan]. Nihon Koshu Eisei Zasshi. 2015;62:325-37 pubmed publisher
    ..Prior to System introduction, we should facilitate consensus-building about protecting and utilizing personal information as well as consider the related ethical issues, and doctors' characteristics and concerns. ..
  79. Distler F, Radtke J, Kesch C, Roethke M, Schlemmer H, Roth W, et al. [Value of MRI/ultrasound fusion in primary biopsy for the diagnosis of prostate cancer]. Urologe A. 2016;55:146-55 pubmed publisher
    ..and 203 significant PCa (Gleason score (GS) ≥ 3 + 4, GS = 3 + 3 and PSA values ≥ 10 ng/ml) were detected...
  80. Li J, Ren S, Piao H, Wang F, Yin P, Xu C, et al. Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer. Sci Rep. 2016;6:20984 pubmed publisher
    ..90-0.96), superior to serum prostate-specific antigen (PSA) (AUC = 0.83)...
  81. Komorowska B, Hasiów Jaroszewska B, Minicka J. Application of nucleic acid aptamers for detection of Apple stem pitting virus isolates. Mol Cell Probes. 2017;36:62-65 pubmed publisher
    DNA aptamers (PSA-H and MT32) were applied for the detection of Apple stem pitting virus (ASPV) isolates using an Enzyme-Linked Oligonucleotide Assay (ELONA) and Western blot analysis...
  82. Yang T, Hou P, Zheng L, Zhan L, Gao P, Li Y, et al. Surface-engineered quantum dots/electrospun nanofibers as a networked fluorescence aptasensing platform toward biomarkers. Nanoscale. 2017;9:17020-17028 pubmed publisher
    ..by nanometal surface energy transfer (NSET) between them both, which are constructed for prostate specific antigen (PSA) assay...
  83. Belicky S, Damborsky P, Zapatero Rodríguez J, O Kennedy R, Tkac J. Full-length antibodies versus single-chain antibody fragments for a selective impedimetric lectin-based glycoprofiling of prostate specific antigen. Electrochim Acta. 2017;246:399-405 pubmed publisher
    ..of the research was to design a functional impedimetric biosensor able to glycoprofile prostate specific antigen (PSA), a biomarker for prostate cancer (PCa), with high specificity using lectins as glycan recognising proteins...
  84. Wang B, Liu X, Chen J, Peng D, He F. Composition and functional group characterization of extracellular polymeric substances (EPS) in activated sludge: the impacts of polymerization degree of proteinaceous substrates. Water Res. 2018;129:133-142 pubmed publisher
    ..Proteinaceous substrates (ProS) present in heterogeneous polymeric form are intrinsic and important parts of wastewater substrates for ..
  85. Raps M, Helmerhorst F, Fleischer K, Dahm A, Rosendaal F, Rosing J, et al. The effect of different hormonal contraceptives on plasma levels of free protein S and free TFPI. Thromb Haemost. 2013;109:606-13 pubmed publisher
    ..The effect of oral contraceptives on TFPI and PS is a possible explanation for the increased risk of venous thrombosis associated with oral contraceptives. ..
  86. Alhenc Gelas M, Plu Bureau G, Horellou M, Rauch A, Suchon P. PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency. Thromb Haemost. 2016;115:570-9 pubmed publisher
    ..data are conflicting concerning risk of VTE associated with decreased free PS level (FPS) and information on PROS1 genotype-phenotype relationship is sparse...
  87. Wroblewska Seniuk K, Dabrowski P, Szyfter W, Mazela J. Universal newborn hearing screening: methods and results, obstacles, and benefits. Pediatr Res. 2017;81:415-422 pubmed publisher
    ..this review is to present the objectives, benefits, and results of newborn hearing screening programs including the pros and cons of universal vs. selective screening...
  88. Matsukawa Y, Asano E, Tsuda T, Kuma H, Kitaori T, Katano K, et al. Genotyping analysis of protein S-Tokushima (K196E) and the involvement of protein S antigen and activity in patients with recurrent pregnancy loss. Eur J Obstet Gynecol Reprod Biol. 2017;211:90-97 pubmed publisher
    ..There was no association between PS-Tokushima and RPL and a PS deficiency or low PS activity was shown not to serve as a reliable clinical predictor of subsequent miscarriage. ..
  89. Saarimäki L, Hugosson J, Tammela T, Carlsson S, Talala K, Auvinen A. Impact of Prostatic-specific Antigen Threshold and Screening Interval in Prostate Cancer Screening Outcomes: Comparing the Swedish and Finnish European Randomised Study of Screening for Prostate Cancer Centres. Eur Urol Focus. 2019;5:186-191 pubmed publisher
    ..Prostate Cancer trial has shown a 21% reduction in prostate cancer (PC) mortality with prostate-specific antigen (PSA)-based screening...
  90. Wormald J, Rodrigues J. Outcome measurement in plastic surgery. J Plast Reconstr Aesthet Surg. 2018;71:283-289 pubmed publisher
    ..Greater emphasis is being placed on patient-reported outcomes (PROs), in which the patients' perspective is measured directly from them...
  91. Morote J, Trilla E, Esquena S, Serrallach F, Abascal J, Id H Mammed Y, et al. Value of percent free prostate-specific antigen for the prediction of pathological stage in men with clinically localized prostate cancer. Int J Biol Markers. 2002;17:239-43 pubmed
    To analyze if the percentage of free prostate-specific antigen (PSA) can provide additional information to the combination of local clinical stage, serum PSA and Gleason score in the prediction of final stage and pathological features of ..
  92. Wang Z, Zhao Z, Xu K, Sun G, Song L, Yin H, et al. Hereditary protein S deficiency leads to ischemic stroke. Mol Med Rep. 2015;12:3279-3284 pubmed publisher
    ..9%, which was significantly decreased compared with normal levels. Sequencing analysis revealed a PROS1 c.1486_1490delGATTA mutation on exon 12...