prominin 2


Gene Symbol: prominin 2
Description: prominin 2
Alias: PROML2, prominin-2, prominin-like protein 2, prominin-related protein
Species: human
Products:     prominin 2

Top Publications

  1. Fujimoto M, Hayashida N, Katoh T, Oshima K, Shinkawa T, Prakasam R, et al. A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock. Mol Biol Cell. 2010;21:106-16 pubmed publisher
    ..We propose that mHSF3 represents a unique HSF that has the potential to activate only nonclassical heat-shock genes to protect cells from detrimental stresses. ..
  2. Reuter C, Opitz R, Soicke A, Dohmen S, Barone M, Chiha S, et al. Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation. Chemistry. 2015;21:8464-70 pubmed publisher
    ..As a proof of concept, it was shown that certain peptides containing ProM-2 exhibited improved (canonical) binding towards the Ena/VASP homology 1 (EVH1) domain as a relevant protein interaction target. ..
  3. Kaneko T, Kono N, Sunakawa T, Okuno Y, Ikegami H, Musha Y. Reliable patient-reported outcome measure and survivorship of UKA for primary spontaneous osteonecrosis. Eur J Orthop Surg Traumatol. 2019;29:119-124 pubmed publisher
    ..7% at 10 years (95% confidence interval 0.76-0.99). The present study demonstrated that primary spontaneous osteonecrosis of the knee (SPONK) can be successfully be treated with UKA at a mean follow-up of 6.6 years. II. ..
  4. Bao L, Zhang Y, Wang J, Wang H, Dong N, Su X, et al. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer. Cell Biol Toxicol. 2016;32:419-35 pubmed publisher
    ..Our results suggested that a number of altered chromosome 2 genes have the subtype or stage specificities of lung cancer and may be considered as diagnostic and prognostic biomarkers. ..
  5. Mendioroz M, Celarain N, Altuna M, Sánchez Ruiz de Gordoa J, Zelaya M, Roldán M, et al. CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer's disease. Alzheimers Res Ther. 2016;8:15 pubmed publisher
    ..Further studies are guaranteed to elucidate the precise role that CRTC1 methylation plays in AD pathophysiology. ..
  6. Fargeas C, Florek M, Huttner W, Corbeil D. Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. J Biol Chem. 2003;278:8586-96 pubmed
    ..Finally, we present evidence for the existence of a family of pentaspan membrane proteins, the prominins, which are conserved in evolution. ..
  7. Rohan S, Tu J, Kao J, Mukherjee P, Campagne F, Zhou X, et al. Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clin Cancer Res. 2006;12:6937-45 pubmed
    ..To compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes...
  8. Singh R, Schroeder A, Scheffer L, Holicky E, Wheatley C, Marks D, et al. Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis. Biochem Biophys Res Commun. 2013;434:466-72 pubmed publisher
    ..This study provides a new insight for the role for prominins in the regulation of PM lipid organization. ..
  9. Kudo I, Esumi M, Kusumi Y, Furusaka T, Oshima T. Particular gene upregulation and p53 heterogeneous expression in TP53-mutated maxillary carcinoma. Oncol Lett. 2017;14:4633-4640 pubmed publisher

More Information


  1. Jászai J, Fargeas C, Haase M, Farkas L, Huttner W, Corbeil D. Robust expression of Prominin-2 all along the adult male reproductive system and urinary bladder. Histochem Cell Biol. 2008;130:749-59 pubmed publisher
    ..Taken together our data indicate that, except for the gonad, Prominin-2 is widely and abundantly expressed along the epithelia of various segments of the adult male genitourinary tract. ..
  2. Jászai J, Farkas L, Fargeas C, Janich P, Haase M, Huttner W, et al. Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney. Histochem Cell Biol. 2010;133:527-39 pubmed publisher
    ..Urinary detection of this protein might offer novel diagnostic approaches for studying renal diseases affecting distal segments of the nephron. ..
  3. Yao J, Zhang T, Ren J, Yu M, Wu G. Effect of CD133/prominin-1 antisense oligodeoxynucleotide on in vitro growth characteristics of Huh-7 human hepatocarcinoma cells and U251 human glioma cells. Oncol Rep. 2009;22:781-7 pubmed
    ..Moreover, this study also showed that prominin-2, another protein in the same family as CD133/prominin-1, may not have a similar function. ..