PROKR1

Summary

Gene Symbol: PROKR1
Description: prokineticin receptor 1
Alias: GPR73, GPR73a, PK-R1, PKR1, ZAQ, prokineticin receptor 1, G protein-coupled receptor 73, G protein-coupled receptor ZAQ
Species: human
Products:     PROKR1

Top Publications

  1. Soga T, Matsumoto S, Oda T, Saito T, Hiyama H, Takasaki J, et al. Molecular cloning and characterization of prokineticin receptors. Biochim Biophys Acta. 2002;1579:173-9 pubmed
    ..The tissue distribution of PK-Rs reported in this paper suggests that the prokineticins play multifunctional roles in vivo. ..
  2. Lin D, Bullock C, Ehlert F, Chen J, Tian H, Zhou Q. Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. J Biol Chem. 2002;277:19276-80 pubmed
    ..mRNA expression analysis reveals that prokineticin receptors are expressed in gastrointestinal organs, endocrine glands, and other tissues. ..
  3. Masuda Y, Takatsu Y, Terao Y, Kumano S, Ishibashi Y, Suenaga M, et al. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem Biophys Res Commun. 2002;293:396-402 pubmed
    ..related to EG-VEGF, prokineticin 2, are cognate ligands of two orphan G-protein-coupled receptors designated ZAQ (=EG-VEGF/PK-R1) and I5E (=EG-VEGF/PK-R2)...
  4. Evans J, Catalano R, Morgan K, Critchley H, Millar R, Jabbour H. Prokineticin 1 signaling and gene regulation in early human pregnancy. Endocrinology. 2008;149:2877-87 pubmed publisher
    ..The objective of this study was to investigate the role of PROK1 and prokineticin receptor 1 (PROKR1) in human endometrium during early pregnancy...
  5. Battersby S, Critchley H, Morgan K, Millar R, Jabbour H. Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle. J Clin Endocrinol Metab. 2004;89:2463-9 pubmed
    ..vascular endothelial growth factors are also known as prokineticin (PK) 1 and PK2 and their receptors as PKR1 and PKR2...
  6. Guilini C, Urayama K, Turkeri G, Dedeoglu D, Kurose H, Messaddeq N, et al. Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration. Am J Physiol Heart Circ Physiol. 2010;298:H844-52 pubmed publisher
    Prokineticins are secreted peptides that activate two G protein-coupled receptors: PKR1 and PKR2. Prokineticins induce angiogenesis and fenestration, but the cognate receptors involved in these functions are unknown...
  7. D Aurora M, Romani F, Franchi S, Diomede F, Merciaro I, Impicciatore G, et al. MRAP2 regulates endometrial receptivity and function. Gene. 2019;703:7-12 pubmed publisher
    ..MRAP2 could be considered a mediator of endometrial receptivity likely acting on endometrial stability by binding to MCRs and PKR1.
  8. Zhao Y, Wu J, Wang X, Jia H, Chen D, Li J. Prokineticins and their G protein-coupled receptors in health and disease. Prog Mol Biol Transl Sci. 2019;161:149-179 pubmed publisher
    ..PROK1 and PROK2 bind to two highly related G protein-coupled receptors (GPCRs), prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2). Prokineticins and their receptors are widely expressed...
  9. Lannagan T, Wilson M, Denison F, Norman J, Catalano R, Jabbour H. Prokineticin 1 induces a pro-inflammatory response in murine fetal membranes but does not induce preterm delivery. Reproduction. 2013;146:581-91 pubmed publisher
    ..LPS) induced PTD, but this was not associated with changes in expression of Prok1 or its receptor (Prokr1) in fetal membranes...

More Information

Publications50

  1. Huang X, Jia L, Qian Z, Jia Y, Chen X, Xu X, et al. Diversity in human placental microvascular endothelial cells and macrovascular endothelial cells. Cytokine. 2018;111:287-294 pubmed publisher
    ..HPMECs and HUVECs had different expressions of eNOS, PROKR1 and PROKR2, and these characteristics substantiate the endothelial nature of cultured cells...
  2. Patten G, Kerr C, Dunne R, Shaw J, Bird A, Regina A, et al. Resistant starch alters colonic contractility and expression of related genes in rats fed a Western diet. Dig Dis Sci. 2015;60:1624-32 pubmed publisher
    ..Chrm2, Chrm3), serotonin receptors (Htr5a, Htr7), a protease-activated receptor (F2r), a prokineticin receptor (Prokr1), prokineticin (Prok1), and nitric oxide synthase 2 (Nos2), was altered by dietary HAMS relative to LAMS (P < 0...
  3. Carter T, Kay D, Browne M, Liu A, Romitti P, Kuehn D, et al. Hirschsprung's disease and variants in genes that regulate enteric neural crest cell proliferation, migration and differentiation. J Hum Genet. 2012;57:485-93 pubmed publisher
    ..genes (ASCL1, homeobox B5 (HOXB5), L1 cell adhesion molecule (L1CAM), paired-like homeobox 2b (PHOX2B), PROK1 and PROKR1) chosen because they are involved in ENCC proliferation, migration and differentiation in animal models...
  4. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kawami T, Yamasaki M, et al. Changes in the responsiveness of hypothalamic PK2 and PKR1 gene expression to fasting in developing male rats. Int J Dev Neurosci. 2014;38:87-90 pubmed publisher
    ..It has been reported that PK2 inhibits food intake via PKR1 and that the hypothalamic PK2 mRNA levels of adult rodents were reduced by food deprivation...
  5. Lattanzi R, Maftei D, Negri L, Fusco I, Miele R. PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor. Neuropeptides. 2018;71:32-42 pubmed publisher
    ..PK2 and PK2L (a Long form) which is cleaved in an active peptide, named PK2β that preferentially binds to PKR1 receptor. The aim of this study was to characterize the PK2β...
  6. Lattanzi R, Maftei D, Marconi V, Florenzano F, Franchi S, Borsani E, et al. Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model. Biomed Res Int. 2015;2015:301292 pubmed publisher
    The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2) have a role in inflammatory pain and immunomodulation...
  7. Guida F, Lattanzi R, Boccella S, Maftei D, Romano R, Marconi V, et al. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. Pharmacol Res. 2015;91:36-46 pubmed publisher
    ..They are expressed in the peripheral and central nervous system. PKs bind two G protein coupled receptors, PKR1 and PKR2, and participate in the regulation of several biological processes, including pain sensation...
  8. Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, et al. Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung. Mol Cancer Ther. 2018;17:1515-1525 pubmed publisher
    ..infiltrating neutrophils and 4T1 cells abundantly expressed prokineticin-2 (Prok2) and its receptor, Prokr1, respectively...
  9. Dunand C, Hoffmann P, Sapin V, Blanchon L, Salomon A, Sergent F, et al. Endocrine gland-derived endothelial growth factor (EG-VEGF) is a potential novel regulator of human parturition. Biol Reprod. 2014;91:73 pubmed publisher
    ..Within the FM, the chorion was the main source of EG-VEGF. EG-VEGF receptors, PROKR1 and PROKR2, were differentially expressed within the FM with increased expression toward term and an abrupt ..
  10. Alfaidy N. Prokineticin1 and pregnancy. Ann Endocrinol (Paris). 2016;77:101-4 pubmed publisher
    ..PROK1 acts via two G-protein coupled receptors: PROKR1 PROKR2. PROK1 is highly expressed in the placenta...
  11. Zinni M, Zuena A, Marconi V, Petrella C, Fusco I, Giuli C, et al. Maternal exposure to low levels of corticosterone during lactation protects adult rat progeny against TNBS-induced colitis: A study on GR-mediated anti-inflammatory effect and prokineticin system. PLoS ONE. 2017;12:e0173484 pubmed publisher
    ..iv) the pro-inflammatory cytokines IL-1β and TNF-α, (v) the prokineticins PK2 and PK2L and (vi) their receptors PKR1 and PKR2...
  12. Chen B, Yu L, Wang J, Li C, Zhao K, Zhang H. Involvement of Prokineticin 2 and Prokineticin Receptor 1 in Lipopolysaccharide-Induced Testitis in Rats. Inflammation. 2016;39:534-42 pubmed publisher
    ..Given one of the cognate receptors of prokineticin 2, prokineticin receptor 1 (PKR1) was also significantly upregulated in orchitis as discussed in the current study, it is very ..
  13. Ito H, Noda K, Yoshida K, Otani K, Yoshiga M, Oto Y, et al. Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen-induced arthritis. BMC Musculoskelet Disord. 2016;17:387 pubmed publisher
    ..Localization of PKR1 and PKR2 proteins was examined immunohistochemically...
  14. Meng S, Gu Q, Yang X, Lv J, Owusu I, Matrone G, et al. TBX20 Regulates Angiogenesis Through the PROK2-PROKR1 Pathway. Circulation. 2018;: pubmed publisher
    ..Our study identifies TBX20 as a novel transcription factor regulating angiogenesis through the PROK2-PROKR1 pathway in both development and disease, and reveals a novel mode of angiogenic regulation whereby the TBX20-PROK2-..
  15. Landucci E, Lattanzi R, Gerace E, Scartabelli T, Balboni G, Negri L, et al. Prokineticins are neuroprotective in models of cerebral ischemia and ischemic tolerance in vitro. Neuropharmacology. 2016;108:39-48 pubmed publisher
    ..The development of OGD tolerance was associated with an increase in the expression of PK2, PKR1 and PKR2 mRNA and proteins and was prevented by addition of the antagonist PC7 into the medium during ..
  16. Wang C, Tsai H, Syu J, Chen T, Su M. Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion. J Cell Physiol. 2017;232:1467-1477 pubmed publisher
    ..The receptor of EG-VEGF, PROKR1, was detected in primary cilia...
  17. Chaly A, Srisai D, Gardner E, Sebag J. The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1. elife. 2016;5: pubmed publisher
    ..In this study we identified PKR1 as the first non-melanocortin GPCR to be regulated by MRAP2...
  18. Severini C, Lattanzi R, Maftei D, Marconi V, Ciotti M, Petrocchi Passeri P, et al. Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity. Sci Rep. 2015;5:15301 pubmed publisher
    ..cortical cultures (CNs) and cortex and hippocampus from Aβ treated rats, we found that PROK2 and its receptors PKR1 and PKR2 mRNA are up-regulated by Aβ, suggesting their potential involvement in AD...
  19. Garnier V, Traboulsi W, Salomon A, Brouillet S, Fournier T, Winkler C, et al. PPARγ controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development. Am J Physiol Endocrinol Metab. 2015;309:E357-69 pubmed publisher
    ..EG-VEGF exerts its functions via prokineticin receptor 1 (PROKR1) and 2 (PROKR2)...
  20. Arora H, Boulberdaa M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, et al. Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development. Sci Rep. 2016;6:25541 pubmed publisher
    ..Here we investigated the role of angiogenic hormone, prokineticin-2 and its receptor PKR1 in the epicardium of developing and adult heart...
  21. Arora H, Boulberdaa M, Qureshi R, Bitirim V, Messadeq N, Dolle P, et al. Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development. FASEB J. 2016;30:2733-40 pubmed publisher
    ..Arora, H., Boulberdaa, M., Qureshi, R., Bitirim, V., Messadeq, N., Dolle, P., Nebigil, C. G. Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development.
  22. Pasquali D, Rossi V, Staibano S, De Rosa G, Chieffi P, Prezioso D, et al. The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. Endocrinology. 2006;147:4245-51 pubmed
    ..Thus, the level of EG-VEGF/PK1 could be useful for prostate cancer outcome evaluation and as a target for prostate cancer treatment in the future. ..
  23. Cao Y, Zhang Z, Wang J, Miao M, Xu J, Shen Y, et al. Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss. J Zhejiang Univ Sci B. 2016;17:218-24 pubmed publisher
    ..During the last decade, studies indicated that the expression patterns of the prokineticin receptor (PKR1 and PKR2) are closely related to early pregnancy...
  24. Shaw J, Oliver E, Lee K, Entrican G, Jabbour H, Critchley H, et al. Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. Am J Pathol. 2010;177:2509-15 pubmed publisher
    ..Smoking is a major risk factor for EP. FTs from women with EP exhibit altered prokineticin receptor-1 (PROKR1) expression, the receptor for prokineticins (PROK)...
  25. Cook I, Evans J, Maldonado Pérez D, Critchley H, Sales K, Jabbour H. Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway. Mol Hum Reprod. 2010;16:158-69 pubmed publisher
    ..Previous data from our laboratory using a human genome survey microarray showed that PROK1-prokineticin receptor 1 (PROKR1) signalling regulates numerous genes important for establishment of early pregnancy, including ..
  26. Su M, Lin S, Chen Y, Kuo P. Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms. Fertil Steril. 2014;102:1071-1077.e3 pubmed publisher
    ..None. All blood samples were nucleotide sequenced in the coding regions of EG-VEGF, PROKR1, and PROKR2...
  27. Ruiz Ferrer M, Torroglosa A, Núñez Torres R, De Agustin J, Antinolo G, Borrego S. Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR. PLoS ONE. 2011;6:e23475 pubmed publisher
    ..Recently, PROKR1 expression has been demonstrated in mouse enteric neural crest derived cells and Prok-1 was shown to work ..
  28. Rouault A, Lee A, Sebag J. Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling. Biochim Biophys Acta Mol Cell Res. 2017;1864:2322-2329 pubmed publisher
    ..receptors we have recently shown that it interacts with and inhibits the trafficking and signaling of the prokineticin receptor 1 (PKR1)...
  29. Su M, Lin S, Chen Y, Wu L, Kuo P. Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy. Reproduction. 2013;146:63-73 pubmed publisher
    Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor genes (PROKR1 (PKR1) and PROKR2 (PKR2)) play an important role in human early pregnancy...
  30. Levit A, Yarnitzky T, Wiener A, Meidan R, Niv M. Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs. PLoS ONE. 2011;6:e27990 pubmed publisher
    ..In addition, analysis of the intracellular regions highlights variable regions that may provide subtype specificity. ..
  31. Traboulsi W, Sergent F, Boufettal H, Brouillet S, Slim R, Hoffmann P, et al. Antagonism of EG-VEGF Receptors as Targeted Therapy for Choriocarcinoma Progression In Vitro and In Vivo. Clin Cancer Res. 2017;23:7130-7140 pubmed publisher
    ..EG-VEGF acts via two receptors, PROKR1 and PROKR2. Here, we demonstrate that EG-VEGF receptors can be targeted for CC therapy...
  32. Szuber M, Markwitz W, Ropacka M, Breborowicz G. The possible role of the PK1 and its receptor in the etiology of the preeclampsia. Neuro Endocrinol Lett. 2011;32:563-72 pubmed
    ..In our study we investigated the expression, localization, and signaling pathways of PK1 and PKR1 in third-trimester human placenta and myometrium and assessed the correlation between the PK1 and PKR1 expression ..
  33. Benlahfid M, Traboulsi W, Sergent F, Benharouga M, Elhattabi K, Erguibi D, et al. Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor PROKR2 are associated to human colorectal cancer progression and peritoneal carcinomatosis. Cancer Biomark. 2017;: pubmed publisher
    ..factor which biological activity is mediated via two G protein-coupled receptors, prokineticin receptor1 (PROKR1) and PROKR2...
  34. Brouillet S, Hoffmann P, Chauvet S, Salomon A, Chamboredon S, Sergent F, et al. Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors. Cell Mol Life Sci. 2012;69:1537-50 pubmed publisher
    ..Its biological activity is mediated via two G protein-coupled receptors, prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2)...
  35. Eddie S, Childs A, Kinnell H, Brown P, Jabbour H, Anderson R. Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2. J Clin Endocrinol Metab. 2015;100:E1197-205 pubmed publisher
    ..Functional studies were performed using a human germ cell tumor line (TCam-2) stably transfected with Prokineticin receptor 1 (PROKR1)...
  36. Li Q, Zhu H, Yang Y, Liu J, Xiao F, Zhang Q, et al. Prokineticin-1/endocrine gland-derived vascular endothelial growth factor is a survival factor for human multiple myeloma cells. Leuk Lymphoma. 2010;51:1902-12 pubmed publisher
    ..Taken together, PK1 activates multiple signaling pathways and, upregulates Mcl-1 expression, leading to proliferation and survival of MM cells. ..
  37. Traboulsi W, Brouillet S, Sergent F, Boufettal H, Samouh N, Aboussaouira T, et al. Prokineticins in central and peripheral control of human reproduction. Horm Mol Biol Clin Investig. 2015;24:73-81 pubmed publisher
    ..PROKs activate two G-protein linked receptors (prokineticin receptor 1 and 2, PROKR1 and PROKR2)...
  38. Qureshi R, Kindo M, Arora H, Boulberdaa M, Steenman M, Nebigil C. Prokineticin receptor-1-dependent paracrine and autocrine pathways control cardiac tcf21+ fibroblast progenitor cell transformation into adipocytes and vascular cells. Sci Rep. 2017;7:12804 pubmed publisher
    ..In this study utilizing transgenic mice overexpressing prokineticin receptor (PKR1) in cardiomyocytes, and tcf21ERT-creTM-derived cardiac fibroblast progenitor (CFP)-specific PKR1 ..
  39. Parker R, Liu M, Eyre H, Copeland N, Gilbert D, Crawford J, et al. Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. Biochim Biophys Acta. 2000;1491:369-75 pubmed
    Two novel G-protein-coupled receptors, one from human, GPR72, and one from mouse, GPR73 have been isolated, sequenced and their genomic organisation determined...
  40. Su M, Lin S, Lee I, Chen Y, Hsu C, Pan H, et al. Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss. Hum Reprod. 2010;25:2923-30 pubmed publisher
    Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor genes [prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2)] have been identified in the last decade and their expression is restricted to ..
  41. Heck D, Wortmann S, Kraus L, Ronchi C, Sinnott R, Fassnacht M, et al. Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors. Horm Cancer. 2015;6:225-36 pubmed
    ..antiapoptotic, mitogenic, and chemoattractive properties mediated via the two G protein-coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2)...