Genomes and Genes
Gene Symbol: PRODH
Description: proline dehydrogenase (oxidase) 1
Alias: HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6, p53-induced gene 6 protein, proline dehydrogenase 1, mitochondrial, proline oxidase 2, proline oxidase, mitochondrial, tumor protein p53 inducible protein 6
Publications169 found, 100 shown here
- Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1A E Pulver
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore 21231
Am J Med Genet 54:36-43. 1994..1). Reanalyses, varying parameters in the dominant model, maximized the LRH at 660.7 (maximum lod score 2.82). This finding is of sufficient interest to warrant further investigation through collaborative studies...
- [Serologic studies of domestic cats for potential human pathogenic virus infections from wild rodents]N Nowotny
Institut fur Virologie, Veterinärmedizinischen Universität Wien
Zentralbl Hyg Umweltmed 198:452-61. 1996..in different ways, may lead to serious human illness: Ortho- and parapoxvirus infections may cause localized pox lesions following direct skin contact...
- Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1)C E Furlong
Department of Genetics, University of Washington, Seattle 98195 7360, USA
Neurotoxicology 21:91-100. 2000..The Arg192 isoform (PON1R192) of this HDL-associated protein hydrolyzes paraoxon (POX) at a high rate, while the Gln192 isoform (PON1Q192) hydrolyzes paraoxon at a low rate...
- Characterization of poxviruses from forest birds in HawaiiD N Tripathy
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA
J Wildl Dis 36:225-30. 2000Two strains of avian pox viruses were isolated from cutaneous lesions in Hawaiian crows (Corvus hawaiiensis) examined in 1994 and a third from a biopsy obtained in 1992 from an infected bird of the Apapane species (Himatione sanguinea) ..
- Oxidative stress induction by Prunus necrotic ringspot virus infection in apricot seedsKhalid Amari
Department of Stress Biology and Plant Pathology, CEBAS CSIC, PO Box 164, 30100 Espinardo, Murcia, Spain
Physiol Plant 131:302-10. 2007..A significant decrease in the ascorbate-GSH cycle enzymes as well as in peroxidase (POX) activity took place in infected seeds, suggesting a low capability to eliminate H2O2...
- Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen speciesS P Donald
Division of Basic Science, National Cancer Institute, Frederick, Maryland 21702, USA
Cancer Res 61:1810-5. 2001The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to ..
- Proline oxidase functions as a mitochondrial tumor suppressor in human cancersYongmin Liu
Basic Science Program and Pathology Histotechnology Laboratory, Science Applications International Corporation Frederick, Inc, and Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
Cancer Res 69:6414-22. 2009..Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as ..
- Regulation and function of proline oxidase under nutrient stressJui Pandhare
Metabolism and Cancer Susceptibility Section, Laboratory of Comparative, Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
J Cell Biochem 107:759-68. 2009..extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP...
- A model for p53-induced apoptosisK Polyak
The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 389:300-5. 1997....
- Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomasSteve A Maxwell
Texas A and M University System Health Science Center, Department of Pathology and Laboratory Medicine, College Station, Texas 77843 1114, USA
J Biol Chem 278:9784-9. 2003..The presence of proline oxidase in mitochondria, a primary organelle that regulates apoptosis, places this molecule in a subcellular localization that can directly influence the apoptotic pathway and thus tumorigenesis...
- Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11M Karayiorgou
Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
Proc Natl Acad Sci U S A 92:7612-6. 1995..Our findings should facilitate identification and cloning of the schizophrenia susceptibility gene(s) in this region and identification of more homogeneous subgroups of patients...
- Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophreniaHui Liu
Human Neurogenetics Laboratory, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 99:3717-22. 2002..In three independent samples, we provide evidence for a contribution of the PRODH2/DGCR6 locus in 22q11-associated schizophrenia...
- PRODH mutations and hyperprolinemia in a subset of schizophrenic patientsHélène Jacquet
INSERM EMI 9906, IRFMP, Faculty of Medicine, 76183 Rouen, France
Hum Mol Genet 11:2243-9. 2002..led us to identify, in a family including two schizophrenic subjects, a heterozygous deletion of the entire PRODH gene encoding proline dehydrogenase...
- Functional consequences of PRODH missense mutationsHans Ulrich Bender
Howard Hughes Medical Institute, and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Hum Genet 76:409-20. 2005b>PRODH maps to 22q11 in the region deleted in the velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane enzyme that catalyzes the first step in the proline degradation ..
- No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
Psychiatr Genet 15:195-8. 2005..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder...
- Early neurological phenotype in 4 children with biallelic PRODH mutationsAlexandra Afenjar
AP HP, Service de Neuropediatrie, Hopital Armand Trousseau, Paris, France
Brain Dev 29:547-52. 2007..Diverse phenotypes were described in patients with HPI, prior to the identification of the POX gene (PRODH): whereas various patients were asymptomatic, others had neurological and extraneurological defects...
- Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysisDawei Li
Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
Eur J Hum Genet 14:1130-5. 2006..and functional studies have implicated the regulator of G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes as promising and novel candidates for explaining schizophrenia...
- Hyperprolinemia is a risk factor for schizoaffective disorderH Jacquet
INSERM U614, IFRMP, Faculte de Medecine, Rouen 76183, France
Mol Psychiatry 10:479-85. 2005..we identified several heterozygous alterations, including a complete deletion, of the proline dehydrogenase (PRODH) gene, which were associated with moderate hyperprolinemia in a subset of DSM III schizophrenic patients...
- Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese populationTao Li
Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 129:13-5. 2004..disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al...
- The severe form of type I hyperprolinaemia results from homozygous inactivation of the PRODH geneH Jacquet
INSERM EMI 9906 IFRMP, Faculty of Medicine, Rouen, France
J Med Genet 40:e7. 2003
- Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanismsJui Pandhare
Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, MD 21702, USA
J Biol Chem 281:2044-52. 2006Proline oxidase (POX) is a redox enzyme localized in the mitochondrial inner membrane. We and others have shown that POX is a p53-induced gene that can mediate apoptosis through generation of reactive oxygen species (ROS)...
- Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosisChien an A Hu
Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM, USA
Mol Cell Biochem 295:85-92. 2007Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C)...
- Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibilityBeate Glaser
Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
Schizophr Res 87:21-7. 2006..hypothesis, our study aimed to explore main, cis- and trans-interacting effects of three candidate genes on 22q11, ProDH, COMT and ZDHHC8...
- Detailed analysis of PRODH and PsPRODH reveals no association with schizophreniaH J Williams
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003..Recently, the gene proline dehydrogenase (PRODH) which maps to 22q11 and is also an excellent functional candidate gene for psychosis, has been reported to show ..
- Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signalingY Liu
Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
Oncogene 25:5640-7. 2006Proline oxidase (POX), often considered a 'housekeeping enzyme' might play an important role in apoptosis...
- Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndromeGregory Raux
Department of Genetics and Inserm U614, IFRMP, Faculty of Medicine, Rouen, France
Hum Mol Genet 16:83-91. 2007..mouse model that an interaction between two genes localized in the hemideleted region, proline dehydrogenase (PRODH) and catechol-o-methyl-transferase (COMT), could be involved in this phenotype...
- [Biohazard in clinical laboratories in Japan]T Masuda
Department of Internal Medicine, Nagoya National Hospital
Kansenshogaku Zasshi 65:209-15. 1991..one case of campylobacter enteritis, one case of paratyphus, one case of salmonellosis and one case of chicken pox. There were no fatal cases...
- Inborn errors of proline metabolismHiroshi Mitsubuchi
Department of Pediatrics, Kumamoto University Graduate School of Medical Science, Kumamoto University, Kumamoto 860 8556, Japan
J Nutr 138:2016S-2020S. 2008..Hyperprolinemia type I (HPI) is a result of a deficiency in POX. The POX gene (PRODH) is located on chromosome 22 (22q11...
- The metabolism of proline as microenvironmental stress substrateJames M Phang
Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Nutr 138:2008S-2015S. 2008..Studies show that the proline-utilizing enzyme, proline oxidase (POX)/proline dehydrogenase (PRODH), responds to genotoxic, inflammatory, and nutrient stress...
- A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen speciesSandra K Cooper
Basic Research Program, SAIC Frederick, Inc, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
J Biol Chem 283:10485-92. 2008..The first steps in the degradation of proline and hydroxyproline are catalyzed by proline oxidase (POX) and hydroxyproline oxidase (OH-POX), respectively...
- Standard guidelines of care: CO2 laser for removal of benign skin lesions and resurfacingD S Krupashankar
Department of Dermatology, Manipal Hospital, Bangalore, India
Indian J Dermatol Venereol Leprol 74:S61-7. 2008Resurfacing is a treatment to remove acne and chicken pox scars, and changes in the skin due to ageing. MACHINES: Both ablative and nonablative lasers are available for use. CO 2 laser is the gold standard in ablative lasers...
- miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancerW Liu
Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
Oncogene 29:4914-24. 2010Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF) signaling...
- Type I hyperprolinemia: genotype/phenotype correlationsAudrey Guilmatre
INSERM U614, IHU, 76000 Rouen, France
Hum Mutat 31:961-5. 2010..associated with cognitive and psychiatric troubles, caused by alterations of the Proline Dehydrogenase gene (PRODH) at 22q11. HPI results from PRODH deletion and/or missense mutations reducing proline oxidase (POX) activity...
- Identification of a p53-response element in the promoter of the proline oxidase geneSteve A Maxwell
Department of Molecular and Cellular Medicine, Room 252, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
Biochem Biophys Res Commun 369:308-13. 2008Proline oxidase (POX) is a p53-induced proapoptotic gene. We investigated whether p53 could bind directly to the POX gene promoter. Chromatin immunoprecipitation (ChIP) assays detected p53 bound to POX upstream gene sequences...
- The metabolism of proline, a stress substrate, modulates carcinogenic pathwaysJames M Phang
Laboratory of Comparative Carcinogenesis, Center for Cancer Research, Building 538, Room 115, NCI Frederick, Frederick, MD 21702, USA
Amino Acids 35:681-90. 2008..Proline oxidase, a.k.a. proline dehydrogenase (POX/PRODH), catalyzes the first step in proline degradation and uses proline to generate ATP for survival or reactive oxygen ..
- Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formationKi Young Kim
Center for Metabolic Syndrome Therapeutics, Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Korea
Mol Pharmacol 72:674-85. 2007..Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists...
- Tiapride pre-treatment in acute exposure to paraoxon: comparison of effects of administration at different points-in-time in ratsG A Petroianu
Department of Pharmacology, FMHS UAE University, Al Ain, UAE
Mol Cell Biochem 285:79-86. 2006..We also have shown recently that in rats coadministration of TIA with the organophosphate paraoxon significantly decreases mortality without having an impact on red blood cell cholinesterase (RBC-AChE) activity...
- [Clinico-pathological aspect of HIV-sero positive inpatients]H Fujita
First Department of Internal Medicine, Yokohama City University School of Medicine
Kansenshogaku Zasshi 69:398-403. 1995..encephalopathy and systemic various infection, including Pneumocystis carinii, cytomegalovirus, papilloma virus and pox virus...
- Peculiarities of dermatomyositis (DM) in early ageT V Ryabova
First Moscow Medical Institute, USSR
Acta Univ Carol Med (Praha) 37:3-5. 1991..The most frequent intercurrent diseases were respiratory infections, angina; the chicken-pox was frequent too. 12 children had food allergy and 20 children-drug allergy...
- Differential detection of turkey coronavirus, infectious bronchitis virus, and bovine coronavirus by a multiplex polymerase chain reactionC C Loa
Department of Veterinary Pathobiology and Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN 47907 2065, USA
J Virol Methods 131:86-91. 2006..There were no PCR products with the same primers for Newcastle disease virus, Marek's disease virus, turkey pox virus, pigeon pox virus, fowl pox virus, reovirus, infectious bursal disease virus, enterovirus, astrovirus, ..
- Protective vaccination of ferrets against canine distemper with recombinant pox virus vaccines expressing the H or F genes of rinderpest virusL Jones
Department of Veterinary Pathology, University of California, Davis 95616, USA
Am J Vet Res 58:590-3. 1997To investigate the ability of rinderpest virus (RPV) antigens, expressed in pox virus vectors, to protect against canine distemper virus (CDV) infection in ferrets.
- Field trial in commercial broilers with a multivalent in ovo vaccine comprising a mixture of live viral vaccines against Marek's disease, infectious bursal disease, Newcastle disease, and fowl poxJ M Sharma
Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
Avian Dis 46:613-22. 2002..19%; FPV, 86% vs. 0%. The successful use of MIV under field conditions expands the usefulness of the in ovo technology for poultry...
- In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxonG A Petroianu
UAE University, Al Ain UAE
J Appl Toxicol 27:168-75. 2007..available (pralidoxime and methoxime) and experimental (K-27, K-33 and K-48) oximes, using methyl-paraoxon (methyl-POX) as an esterase inhibitor and to compare the results with those previously obtained using paraoxon (POX) as an ..
- Immunization, abrasion, and sunburn as localizing factors in chicken poxW B Shelley
Department of Medicine, Medical College of Ohio, Toledo 43699
Pediatr Dermatol 4:102-4. 1987..This suggests that an injection given during an occult viremia could trigger an unexpected reaction at the site...
- Smallpox vaccination and bioterrorism with pox virusesAnton Mayr
Institute of Microbiology, Infectious and Epidemic Diseases of the Veterinary, Faculty of the Ludwig Maximilian, University of Munich, Weiheimer Strasse 1, 823 19, Starnberg, Germany
Comp Immunol Microbiol Infect Dis 26:423-30. 2003..occupy a special place amongst the innumerable potential types of terrorist attack, with the intentional release of pox viruses being especially feared in this connection...
- Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxonG A Petroianu
UAE University, Al Ain UAE
J Appl Toxicol 26:64-71. 2006..Paraoxon (POX), the active metabolite of parathion (O,O-diethyl-O-p-nitro-phenyl phosphorothioate) is a non-neuropathic ..
- Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxonGeorg A Petroianu
Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
Arch Toxicol 80:777-84. 2006..to quantify in vivo the effect of PSTG pre-treatment on survival in rats exposed to the organophosphate paraoxon (POX) with and without subsequent reactivator (pralidoxime) treatment...
- Dispersal of Culex quinquefasciatus (Diptera: Culicidae) in a Hawaiian rain forestD A LaPointe
U S Geological Survey, Pacific Island Ecosystems Research Center, P O Box 44, Hawaii National Park, HI 96718, USA
J Med Entomol 45:600-9. 2008Introduced mosquito-borne pathogens avian malaria (Plasmodium relictum Grassi and Feletti) and avian pox virus (Avipoxvirus) have been implicated in the past extinctions and declines of Hawaiian avifauna and remain significant obstacles ..
- Expression of self-complementary hairpin RNA under the control of the rolC promoter confers systemic disease resistance to plum pox virus without preventing local infectionTiziana Pandolfini
Dipartimento Scientifico Tecnologico, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy
BMC Biotechnol 3:7. 2003..Plum pox virus (PPV) is the etiological agent of sharka disease in Drupaceae, although it can also be transmitted to ..
- Analysis of the complete genome of peach chlorotic mottle virus: identification of non-AUG start codons, in vitro coat protein expression, and elucidation of serological cross-reactionsD James
Centre for Plant Health, Research Section, Sidney Laboratory, Canadian Food Inspection Agency, Sidney, British Columbia, Canada
Arch Virol 152:2207-15. 2007..Agua virus (4N6), was sequenced and analysed. PCMV cross-reacts with antisera to diverse viruses, such as plum pox virus (PPV), genus Potyvirus, family Potyviridae; and apple stem pitting virus (ASPV), genus Foveavirus, family ..
- Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in ratsG A Petroianu
Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
J Appl Toxicol 25:68-73. 2005..This study evaluates RAN-conferred protection in acute high-dose organophosphate (paraoxon, POX) exposure in rats in direct comparison with the therapeutic gold-standard pralidoxime (PRX)...
- Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxonG A Petroianu
UAE University, Al Ain UAE
J Appl Toxicol 26:262-8. 2006..The purpose of the study was to quantify in vivo the extent of oxime-conferred protection, using paraoxon (POX) as a cholinesterase inhibitor and to test whether in vitro efficacy translates to protection from mortality...
- New K-Oximes (K-27 and K-48) in Comparison with Obidoxime (LuH-6), HI-6, Trimedoxime (TMB-4), and Pralidoxime (2-PAM): Survival in Rats Exposed IP to the Organophosphate ParaoxonG A Petroianu
United Arab Emirates University, Al Ain United Arab Emirates
Toxicol Mech Methods 17:401-8. 2007..K-27 and K-48) in male rats with that of obidoxime (LuH-6), trimedoxime (TMB-4), and HI-6, using paraoxon (POX) as a cholinesterase inhibitor. Pralidoxime (2-PAM) was also retested. Seven groups of six rats each were used...
- Intravenous pyruvic acid application in minipigs partially protects acetylcholine-esteratic but not butyrylcholine-esteratic activity in plasma from inhibition by paraoxonGeorg A Petroianu
United Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pharmacology, Al Ain, United Arab Emirates
J Appl Toxicol 23:37-42. 2003Intoxications with organophosphorus compounds such as paraoxon (POX) are frequent. Oximes are the only enzyme reactivators clinically available...
- Utilization of mucus from the coral Acropora palmata by the pathogen Serratia marcescens and by environmental and coral commensal bacteriaCory J Krediet
University of Florida, Gainesville, 32611, USA
Appl Environ Microbiol 75:3851-8. 2009..S. marcescens PDL100 (a pathogen associated with white pox disease of Acroporid corals) grew to higher population densities on components of mucus from the host coral...
- [Influence of different gelatin concentration and lymphocyte isolation liquid on primary culture of umbilical cord blood derived adhesive cells]Cheng Zhang
Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:1437-41. 2008..Cytochemistry stain for nonspecific esterase stain (NSE), peroxidase (POX), periodic acid Schiff reaction (PAS) and alkali phosphatase (ALP) and immunocytochemistry labeling for CD31, CD45, ..
- Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protectionG Petroianu
University of Heidelberg at Mannheim, Department of Pharmacology and Toxicology, Maybach Street 14 16, 68169 Mannheim, Germany
J Appl Toxicol 21:7-13. 2001Intoxication with the organophosphorus compound paraoxon (POX), an inhibitor of serine hydrolases, is frequent...
- Landscape factors influencing the spatial distribution and abundance of mosquito vector Culex quinquefasciatus (Diptera: Culicidae) in a mixed residential-agricultural community in Hawai'iMatthew E Reiter
Research Corporation of the University of Hawai i, 2530 Dole Street, Sakamaki Hall D 100, Honolulu, HI 96822, USA
J Med Entomol 44:861-8. 2007Mosquito-borne avian diseases, principally avian malaria (Plasmodium relictum Grassi and Feletti) and avian pox (Avipoxvirus sp...
- Detection of reticuloendotheliosis virus as a contaminant of fowl pox vaccinesA M Awad
Department of Avian and Aquatic Animal Medicine, Faculty of Veterinary Medicine, Alexandria University, Behera, Egypt 22758
Poult Sci 89:2389-95. 2010This study was designed to detect reticuloendotheliosis virus (REV) as a contaminant in fowl pox vaccines. A total of 30 fowl pox vaccine samples were examined for the presence of REV using both in vitro and in vivo methods...
- Quantification of lumpy skin disease virus following experimental infection in cattleS Babiuk
National Centre for Foreign Animal Disease, Winnipeg MB, Canada
Transbound Emerg Dis 55:299-307. 2008Lumpy skin disease along with sheep pox and goatpox are the most serious poxvirus diseases of livestock, and are caused by viruses that belong to the genus Capripoxvirus within the subfamily Chordopoxvirinae, family Poxviridae...
- Chromatographic analysis of toxic phosphylated oximes (POX): a brief overviewChristian Becker
Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany
Drug Test Anal 2:460-8. 2010..moiety by a nucleophilic attack of the oximate molecule substituting the enzyme and forming a phosphylated oxime (POX)...
- N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivoLiba Sebastian
Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India
Virol J 5:64. 2008..century, several reports described the therapeutic effects of N-methylisatin-beta-Thiosemicarbazone (MIBT) against pox viruses, Maloney leukemia viruses and recently against HIV...
- Modification of low-density lipoprotein during radiolabeling with 99mTc using three labeling methodsG Sobal
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
Q J Nucl Med Mol Imaging 50:334-43. 2006..The influence of the LDL sampling methods, isolation, preparation and radiolabeling of lipoproteins on structure modification and the subsequent imaging behavior has as yet not been addressed in detail...
- Altered gene expression changes in Arabidopsis leaf tissues and protoplasts in response to Plum pox virus infectionMohan Babu
Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, 1391 Sandford St, London, Ontario, N5V 4T3, Canada
BMC Genomics 9:325. 2008..ATH1 array was used to assess global gene expression changes in Arabidopsis thaliana plants infected with Plum pox virus (PPV)...
- [A transcultural view of neurological and mental pathology in a Tzeltal Maya community of the Altos Chiapas]F J Carod
, San Cristobal de las Casas Chiapas,
Rev Neurol 24:848-54. 1996..Migraine, "yaxti-wanjol chawaj' is treated with the raw, crushed roots of the herbs "chopak pox' and "bakte pox' together with the practice of cutting the patient with a piece of glass in the temporal region, ..
- The use of transgenic fruit trees as a resistance strategy for virus epidemics: the plum pox (sharka) modelM Ravelonandro
Station de Pathologie Vegetale, INRA, Centre de Recherche de Bordeaux, BP 81, 33883 Cedex, Villenave D Ornon, France
Virus Res 71:63-9. 2000Sharka or plum pox, caused by Plum pox virus (PPV: genus Potyvirus; Family Potyviridae), is the most serious disease of Prunus...
- Differentiation of sheep pox and goat poxviruses by sequence analysis and PCR-RFLP of P32 geneMadhusudan Hosamani
Pox virus Laboratory, Division of Virology, Indian Veterinary Research Institute, Mukteswar 263 138, Nainital, Uttaranchal State
Virus Genes 29:73-80. 2004Sheep pox and Goat pox are highly contagious viral diseases of small ruminants. These diseases were earlier thought to be caused by a single species of virus, as they are serologically indistinguishable...
- Altered capillary filtration coefficient in parathion- and paraoxon-induced edema in isolated and perfused rabbit lungsA Delaunois
Department of Pharmacology Pharmacotherapy Toxicology, Faculty of Veterinary Medicine, University of Liege, Belgium
Toxicol Appl Pharmacol 116:161-9. 1992..in pulmonary endothelium permeability and in microvascular hemodynamics induced by parathion (Pth) and paraoxon (Pox), its active metabolite, were investigated in isolated, perfused rabbit lungs...
- Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteinsJennifer D Yoder
Oregon State University, Department of Microbiology, 220 Nash Hall, Corvallis, OR 97331 3804, USA
Virol J 3:10. 2006....
- Humoral immune response impairment following excess vitamin E nutrition in the chick and turkeyA Friedman
Department of Animal Sciences, Faculty of Agriculture, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Poult Sci 77:956-62. 1998..Antibodies produced in response to naturally occurring Escherichia coli and to Newcastle disease virus and turkey pox vaccines were determined. In chicks, antibody production in response to E...
- GC content-based pan-pox universal PCR assays for poxvirus detectionYu Li
Centers for Disease Control and Prevention, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Division of Viral and Rickettsial Diseases, Poxvirus and Rabies Branch, Atlanta, Georgia 30329, USA
J Clin Microbiol 48:268-76. 2010..These pan-pox assays amplify DNA from more than 150 different isolates and strains, including from primary clinical materials, ..
- L-lactate reduces in vitro the inhibition of butyrylcholinesterase (BChE) by paraoxon (E 600)G Petroianu
University of Heidelberg at Mannheim, Department of Pharmacology and Toxicology, Mannheim, Germany
J Appl Toxicol 19:329-36. 1999Intoxication with the organophosphorus compound paraoxon (POX), an inhibitor of serine hydrolases, is frequent. Oximes are the only enzyme reactivators clinically available...
- Inhibitory efficacy of cyclosal-nucleoside monophosphates of aciclovir and brivudin on DNA synthesis of orthopoxvi rusesAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, University of Jena, Jena, Germany
Antivir Chem Chemother 17:25-31. 2006..vaccinia and cowpox viruses of several cycloSal-pro-nucleotides of ACV and BVDU, which have proven activity against pox viruses...
- In vitro protection of plasma cholinesterases by metoclopramide from inhibition by paraoxonG Petroianu
United Arab Emirates University, Faculty of Medicine and Health Sciences Department of Pharmacology, Al Ain, United Arab Emirates
J Appl Toxicol 23:75-9. 2003..was to quantify "in vitro" by means of the IC(50)-shift the extent of MCP conferred protection, using paraoxon (POX) as an inhibitor...
- Paraoxon has only a minimal effect on pralidoxime brain concentration in ratsG A Petroianu
Department of Pharmacology and Therapeutics, FMHS, United Arab Emirates University, Al Ain, United Arab Emirates
J Appl Toxicol 27:350-7. 2007..The effect of the organophosphate paraoxon (POX) on pralidoxime (2-PAM) brain entry was therefore determined...
- Sequence analysis of attachment gene of lumpy skin disease and sheep poxvirusesA A El-Kenawy
Departement of Virology, Faculty of Veterinary Medicine Mansoura University, Mansoura 35516, Egypt
Virol Sin 25:409-16. 2010..In the present study 15 skin nodules from LSD suspected cows and 5 scab samples from sheep pox (SP) suspected sheep were collected...
- A vero cell derived combined vaccine against sheep pox and Peste des Petits ruminants for sheepS S Chaudhary
Division of Biological Products, Indian Veterinary Research Institute IVRI, P O Izatnagar 243122, UP, India
Vaccine 27:2548-53. 2009The combined sheep pox and Peste des Petits ruminants (PPR) vaccine was prepared in lyophilized form containing recommended doses of both vaccine viruses. Safety and immunogenicity of this combined vaccine was evaluated in sheep...
- Capripoxvirus G-protein-coupled chemokine receptor: a host-range gene suitable for virus animal origin discriminationChristian Le Goff
CIRAD, UMR Contrôle des Maladies, F 34398 Montpellier, France
J Gen Virol 90:1967-77. 2009The genus Capripoxvirus within the family Poxviridae comprises three closely related viruses, namely goat pox, sheep pox and lumpy skin disease viruses...
- Emerging Capripoxvirus disease outbreaks in Himachal Pradesh, a northern state of IndiaS Verma
Department of Veterinary Microbiology, DGCN COVAS, CSKHPKV, Palampur, Himachal Pradesh, India
Transbound Emerg Dis 58:79-85. 2011Both sheep and goat pox are contagious viral diseases and affect small ruminants and are caused by sheep pox virus and goat pox virus respectively that belong to genus Capripoxvirus of Poxviridae family...
- Pox in the docks: varicella outbreak in an Australian prison systemMichael H Levy
Corrections Health Service, Long Bay Prison Hospital, Matraville, NSW 2036, Australia
Public Health 117:446-51. 2003..2. Highlight the risks of disease transmission within the prison environment. 3. Promote infection control guidelines for high-risk sub-groups within the prison system, including the application of quarantine...
- Characterization of canarypox-like viruses infecting endemic birds in the Galápagos IslandsTeresa Thiel
Department of Biology, University of Missouri St Louis, Missouri 63121, USA
J Wildl Dis 41:342-53. 2005The presence of avian pox in endemic birds in the Galápagos Islands has led to concern that the health of these birds may be threatened by avipoxvirus introduction by domestic birds...
- Mycological examinations on the fungal flora of the chicken combS Grunder
Department of Dermatology and Andrology, Justus Leibig University Giessen, Giessen, Germany
Mycoses 48:114-9. 2005..4%) were found to have clinical signs: only non-specific lesions neither typical of mycosis nor of avian pox such as desquamation with crust formation, yellow to brown or black dyschromic changes, alopecia in the surrounding ..
- Necropsy findings and arbovirus surveillance in mourning doves from the southeastern United StatesRichard W Gerhold
Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
J Wildl Dis 43:129-35. 2007..Trichomonosis constituted 40% (n = 54) of all diagnoses and was the most frequent diagnosis. Toxicoses and avian pox constituted 18.5% (n = 25) and 14.8% (n = 20) of all diagnoses, respectively...
- Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypesOmer Zarchi
The Behavioral Neurogenetics Center, The Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel The Institute for Clinical Neurophysiology and Audiology, Rabin Medical Center, Petah Tikva 49202, Israel The Interdisciplinary Ph D Program in Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel Electronic address
J Psychiatr Res 47:1623-9. 2013..2DS subject and evaluated their association with catechol O-methyltransferase (COMT) and proline dehydrogenase (PRODH) genetic variants...
- Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC)Baldev Vasir
Dana Farber Cancer Institute, Center for Molecular Orthopaedics, Brigham and Women s Hospital, Boston, MA, USA
J Immunother 35:555-69. 2012The fowl pox vector expressing the tumor-associated antigens, mucin-1 and carcinoembryonic antigen in the context of costimulatory molecules (rF-PANVAC) has shown promise as a tumor vaccine...
- Poxvirus antigen staining of immune cells as a biomarker to predict disease outcome in monkeypox and cowpox virus infection in non-human primatesHaifeng Song
Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America
PLoS ONE 8:e60533. 2013..cytometric staining, especially in monocytes and granulocytes succumbed to virus infection and that early positive pox staining is a strong predictor for lethality. Samples from four independent studies were analyzed...
- Transfection of Arabidopsis protoplasts with a Plum pox virus (PPV) infectious clone for studying early molecular events associated with PPV infectionMohan B Raghupathy
Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, 1391 Sandford St, London, Ontario, Canada N5V 4T3
J Virol Methods 136:147-53. 2006..for Arabidopsis protoplast isolation and transfection to study the infection and replication of a potyvirus, Plum pox virus (PPV)...
- Identification of secret agent as the O-GlcNAc transferase that participates in Plum pox virus infectionD Chen
Department of Plant Molecular Genetics, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma de Madrid, Spain
J Virol 79:9381-7. 2005..The N terminus of the capsid protein (CP) of Plum pox virus (PPV) isolated from Nicotiana clevelandii is O-GlcNAc modified...
- Unusual response in mediated biosensors with an oxidase/peroxidase bienzyme systemRyuhei Matsumoto
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan
Anal Chem 74:3297-303. 2002Mediated biosensors consisting of an oxidase and peroxidase (POx) have attracted increasing attention because of their wide applicability...
- Accumulation of the long class of siRNA is associated with resistance to Plum pox virus in a transgenic woody perennial plum treeJean Michel Hily
USDA ARS Appalachian Fruit Research Station, 2217 Wiltshire Rd, Kearneysville, WV 25430, USA
Mol Plant Microbe Interact 18:794-9. 2005..that are resistant to Plum pox virus (PPV)...
- Conjugates of superoxide dismutase 1 with amphiphilic poly(2-oxazoline) block copolymers for enhanced brain delivery: synthesis, characterization and evaluation in vitro and in vivoJing Tong
Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States
Mol Pharm 10:360-77. 2013..of SOD1 across the blood-brain barrier (BBB) and in neurons the enzyme was conjugated with poly(2-oxazoline) (POx) block copolymers, P(MeOx-b-BuOx) or P(EtOx-b-BuOx), composed of (1) hydrophilic 2-methyl-2-oxazoline (MeOx) or 2-..
- Effects of salicylic acid and cold treatments on protein levels and on the activities of antioxidant enzymes in the apoplast of winter wheat leavesEsen Taşgin
Department of Chemistry, Faculty of Science and Arts, Ataturk University, 25240 Erzurum, Turkey
Phytochemistry 67:710-5. 2006..salicylic acid (SA) and cold on apoplastic protein levels and activities of apoplastic catalase (CAT), peroxidase (POX) and polyphenol oxidase (PPO) were investigated in winter wheat (Triticum aestivum cv. Dogu-88) leaves...
- Pathogenicity determinants in the complex virus population of a Plum pox virus isolateP Saenz
Centro Nacional de Biotecnologia CSIC, Campus de la Universidad Autonoma de Madrid, Spain
Mol Plant Microbe Interact 14:278-87. 2001Several subisolates were separated from a single Plum pox virus (PPV) isolate, PPV-PS. In spite of an extremely high sequence conservation (more than 99...
- Crystal structures and kinetics of monofunctional proline dehydrogenase provide insight into substrate recognition and conformational changes associated with flavin reduction and product releaseMin Luo
Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
Biochemistry 51:10099-108. 2012Proline dehydrogenase (PRODH) catalyzes the FAD-dependent oxidation of proline to Δ(1)-pyrroline-5-carboxylate, which is the first step of proline catabolism...
- Heterologous expression and biochemical characterization of novel pyranose 2-oxidases from the ascomycetes Aspergillus nidulans and Aspergillus oryzaeInes Pisanelli
Food Biotechnology Lab, Department of Food Sciences and Technology, BOKU University of Natural Resources and Life Sciences, Vienna, Austria
Appl Microbiol Biotechnol 93:1157-66. 2012A gene encoding a pyranose 2-oxidase (POx; pyranose/oxygen 2-oxidoreductase; glucose 2-oxidase; EC 126.96.36.199) was identified in the genome of the ascomycete Aspergillus nidulans. Attempts to isolate POx directly from A...
- Liver cell transplantation in severe infantile oxalosis--a potential bridging procedure to orthotopic liver transplantation?Bodo B Beck
Institute of Human Genetics, Department of General, Visceral and Cancer Surgery, University of Cologne, and Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, University Hospital Cologne, Cologne, Germany
Nephrol Dial Transplant 27:2984-9. 2012..Liver cell transplantation (LCT) may expand the narrow spectrum of auxiliary measures to buy time until LKTx for infants can be performed more safely...
- Heterologous RNA-silencing suppressors from both plant- and animal-infecting viruses support plum pox virus infectionVarvara I Maliogka
Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
J Gen Virol 93:1601-11. 2012..Recent studies have shown that plum pox potyvirus (PPV) HCPro can be replaced successfully by cucumber vein yellowing ipomovirus P1b, a sequence-unrelated ..
- Nitrate reductase from Triticum aestivum leaves: regulation of activity and possible role in production of nitric oxideE I Galeeva
Kazan Institute of Biochemistry and Biophysics, Kazan Science Center, Russian Academy of Sciences, ul Lobachevskogo 2 31, 420111 Kazan, Russia
Biochemistry (Mosc) 77:404-10. 2012Nitrate reductase (NR) and peroxidase (POX) are important enzymes involved in the metabolism of reactive oxygen (ROS) and nitrogen species in leaves of wheat (Triticum aestivum L.) seedlings...
- Poly(2-oxazoline)s as polymer therapeuticsRobert Luxenhofer
Professur für Makromolekulare Chemie, Department Chemie, Technische Universitat Dresden, Dresden, Germany
Macromol Rapid Commun 33:1613-31. 2012Poly(2-oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics...
- [Small pox--infection, therapy and anaesthesiological management (part 1)]T W Langefeld
Abteilung für Anaesthesiologie, Intensivmedizin und Schmerztherapie Universitätsklinikum Giessen
Anasthesiol Intensivmed Notfallmed Schmerzther 38:445-55. 2003..An outbreak of this smallpox isn't only controlled by new vaccination. In our times we need adapted prevention-standards, pox-alarm plans and quarantine standards.
- XVII International Poxvirus, Asfivirus and Indorviurs SymposiumBertram L Jacobs; Fiscal Year: 2010..This is the premier meeting for the growing community of researchers working on pox and pox-related viruses and for scientists seeking to learn more about the impact of these viruses on basic and ..
- Dev. of Optimized/Adjuvanted Smallpox DNA Vaccine (Gene Gun)T C Wu; Fiscal Year: 2009..Among the poxvirus-encoded proteins, four membrane proteins (A33R, B5R, L1R and A27L) (called 4-pox vaccine) have been shown to generate protective neutralizing antibody responses and host range protein 2 (HRP2, ..
- N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus InfectiAquilur Rahman; Fiscal Year: 2010..the leading antiviral drugs acyclovir, ganciclovir and cidofovir 5) It is nontoxic at dose producing potent anti-pox virus activity in infected mice, in contrast to the high renal toxicity associated with cidofovir 6) It is active ..
- PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDSP A Ferchmin; Fiscal Year: 2010..antidotes development the neuroprotective efficacy of 4R will be tested against two less toxic analogues, paraoxon (POX) and diisopropylfluorophosphate (DFP)...
- SEVENTEENTH INTERNATIONAL HERPESVIRUS WORKSHOPS Hayward; Fiscal Year: 1992..by herpes simplex (HSV) -1 and -2 respectively, eye ulcerations by HSV, infectious mononucleosis by EBV and chicken pox and shingles by varicella- zoster virus (VZV)...
- 26th Intl Herpesvirus Workshop, Regensburg, GermanyJay Nelson; Fiscal Year: 2001..genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV) chicken pox and shingles (VZV)...
- International Herpesvirus Workshop, Cairns, AustraliaJay Nelson; Fiscal Year: 2002..genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
- 25TH INTERNATIONAL HERPESVIRUS WORKSHOPJay Nelson; Fiscal Year: 2000..genital lesions (HSV-2), meningitis and encephalitis (HSV-I and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
- EIGHTEENTH INTERNATIONAL HERPES VIRUS MEETINGJoseph Glorioso; Fiscal Year: 1993..Varicella-zoster virus (VZV) causes chicken pox and shingles, while Epstein-Barr virus (EBV) is responsible for infectious mononucleosis...
- 24TH INTERNATIONAL HERPESVIRUS WORKSHOPFrederick Wang; Fiscal Year: 1999..genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingle (VZV)...
- 15TH INTERNATIONAL HERPESVIRUS WORKSHOPLEONARD ROSENTHAL; Fiscal Year: 1990..such as skin and eye ulcerations (HSV-l), genital lesions (HSV-2), infectious mononucleosis (EBV), and chicken pox and shingles (VZV). In neonates congenital CMV infections are a major cause of mental retardation and birth defects...
- INTERNATIONAL HERPESVIRUS WORKSHOPJay A Nelson; Fiscal Year: 2010..genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
- Molecular mechanisms of gammaherpesvirus latency and reactivationDouglas White; Fiscal Year: 2009..viruses, including the one that causes cold sores, that infect all humans and cause diseases ranging from chicken pox to cancer...
- Structure/Function of Varicella Zoster Virus DNA.William Ruyechan; Fiscal Year: 2009Varicella zoster virus (VZV) is the causative agent of chicken pox and shingles...
- Vidarabine Prodrugs as Anti-Pox Virus AgentsJohn Hilfinger; Fiscal Year: 2007..targeted research and development of therapeutics, vaccines, adjuvants/immunostimulants, and diagnostics for small pox and other viral diseases. At TSRL, Inc...
- GENE REGULATION BY VARICELLA ZOSTER VIRUS 140K. PROTEINJOAN BETZ; Fiscal Year: 1992Varicella-zoster virus (VZV), the causative agent of chicken pox (varicella) and shingles (zoster), shares with other herpesviruses the ability to cause both productive infections as well as to enter a latent state...
- The Role of Infection in Childhood StrokeHeather J Fullerton; Fiscal Year: 2010..whether infections (recent febrile infection, severe acute infections such as meningitis and remote chicken pox) are risk factors for first childhood stroke;2) to determine whether a history of infection prior to a first stroke ..
- MECHANISMS OF DNA REPLICATION AND RECOMBINATION IN HSV-1Paul E Boehmer; Fiscal Year: 2010..is one of eight human herpesviruses that are know to cause diverse diseases ranging from cold sores and chicken pox to mononucleosis and even cancer...
- SPECTROSCOPIC STUDIES OF ENZYME/SUBSTRATE COMPLEXESGeorge Reed; Fiscal Year: 2007..of the microbial pyruvate metabolizing enzymes, pyruvate:ferredoxin oxidoreductase (PFOR) and pyruvate oxidase (POX)...
- Choosing Drug Doses for Biodefense PathogensGeorge Drusano; Fiscal Year: 2009..of drugs to treat patients infected with the Bioterror pathogens Bacillus anthracis, Yersinia pestis and the Pox viruses Vaccinia Virus and Cowpox Virus...
- Improving Absorption and Targeting of Antiviral DrugsJohn Hilfinger; Fiscal Year: 2009..long-term goal of this project for biodefense is to improve the oral absorption of potent, but poorly absorbed anti-pox agents by designing prodrugs targeted to transporters expressed in human intestine and able to be activated by ..
- PML antiviral for AIDSMilton H Werner; Fiscal Year: 2010..In the present case, the Company has screened its compound portfolio against TB, flu (H5N1), pox, mouse polyoma and herpes viruses and seen in vitro antiviral activity...
- Smallpox subunit vaccine in the C-PERL expression systemGEORGE BUCHMAN; Fiscal Year: 2005..process for the production of the subunit vaccine; (2) Completion of a mouse vaccinia challenge model and a monkey pox monkey model using protein produced in the C-PERL larval system; (3) Approval of an IND for testing of the subunit ..
- Improving Absorption and Targeting of Antiviral DrugsJohn Hilfinger; Fiscal Year: 2004..targeted research and development of therapeutics, vaccines, adjuvants/immunostimulants, and diagnostics for small pox and other viral diseases. At TSRL, Inc...
- Functional analysis of Phospholipase D4David Nemazee; Fiscal Year: 2010..Particularly close homologues to PLD4 are found in pox viruses...
- Host responses to smallpox and monkeypoxDavid Relman; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): Despite the almost unparalleled impact of small pox on human history, our knowledge and understanding of the molecular and cellular biology and the pathophysiology of Variola infection ..
- VIRUS CHROMOSOME STRUCTURE: ROLE IN DEVELOPMENTMichael Feiss; Fiscal Year: 2005..Lambda is an excellent model system for studying virion assembly for the large DNA viruses, including the herpes, pox and adenoviruses. These viruses assemble empty protein shells into which the viral chromosome is packaged...