PRMT6

Summary

Gene Symbol: PRMT6
Description: protein arginine methyltransferase 6
Alias: HRMT1L6, protein arginine N-methyltransferase 6, HMT1 hnRNP methyltransferase-like 6, heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, histone-arginine N-methyltransferase PRMT6
Species: human
Products:     PRMT6

Top Publications

  1. Thomas D, Lakowski T, Pak M, Kim J, Frankel A. Förster resonance energy transfer measurements of cofactor-dependent effects on protein arginine N-methyltransferase homodimerization. Protein Sci. 2010;19:2141-51 pubmed publisher
    ..resonance energy transfer (FRET) to determine dissociation constant (K(D)) values for dimerization of PRMT1 and PRMT6. By attaching monomeric Cerulean and Citrine fluorescent proteins to their N-termini, fluorescent PRMTs are formed ..
  2. Hu Z, Xia Y, Guo X, Dai J, Li H, Hu H, et al. A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nat Genet. 2011;44:183-6 pubmed publisher
    ..0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5...
  3. Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field H, et al. Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer. 2011;128:562-73 pubmed publisher
    ..expression levels of genes belonging to the PRMT family and found significantly higher expression of PRMT1 and PRMT6, both of which are Type I PRMTs, in cancer cells of various tissues than in non-neoplastic cells...
  4. Obianyo O, Thompson P. Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J Biol Chem. 2012;287:6062-71 pubmed publisher
    ..Herein, we report studies on the kinetic mechanism of PRMT6. Initial velocity, product inhibition, and dead-end analog inhibition studies with the AcH4-21 and R1 peptides, as ..
  5. Le Clerc S, Limou S, Coulonges C, Carpentier W, Dina C, Taing L, et al. Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). J Infect Dis. 2009;200:1194-201 pubmed publisher
    ..Novel associations with rapid progression (FDR, < or = 25%) were identified for PRMT6 (P = 6.1 x 10(-7); odds ratio [OR], 0.24), SOX5 (P = 1.8 x 10(-6); OR, 0.45), RXRG (P = 3.9 x 10(-6); OR, 3...
  6. Frankel A, Yadav N, Lee J, Branscombe T, Clarke S, Bedford M. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem. 2002;277:3537-43 pubmed
    ..PRMT) family members, a novel gene has been found on chromosome 1 that encodes for an apparent methyltransferase, PRMT6. The polypeptide chain of PRMT6 is 41.9 kDa consisting of a catalytic core sequence common to other PRMT enzymes...
  7. Boulanger M, Liang C, Russell R, Lin R, Bedford M, Wainberg M, et al. Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. J Virol. 2005;79:124-31 pubmed
    ..Here we identify Tat as a substrate for the arginine methyltransferase, PRMT6. Tat is specifically associated with and methylated by PRMT6 within cells...
  8. Sivakumaran H, van der Horst A, Fulcher A, Apolloni A, Lin M, Jans D, et al. Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat. J Virol. 2009;83:11694-703 pubmed publisher
    ..Here we show that the arginine methyltransferase PRMT6 increases Tat protein half-life by 4.7-fold...
  9. Xie B, Invernizzi C, Richard S, Wainberg M. Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region. J Virol. 2007;81:4226-34 pubmed
    ..that the Tat protein of human immunodeficiency virus type 1 (HIV-1) is a substrate for one such enzyme, termed PRMT6. However, the mechanism by which arginine methylation impairs the transactivation potential of Tat and the sites ..

More Information

Publications69

  1. El Andaloussi N, Valovka T, Toueille M, Steinacher R, Focke F, Gehrig P, et al. Arginine methylation regulates DNA polymerase beta. Mol Cell. 2006;22:51-62 pubmed
    ..Pol beta was found to form a complex with the protein arginine methyltransferase 6 (PRMT6) and was specifically methylated in vitro and in vivo...
  2. Iberg A, Espejo A, Cheng D, Kim D, Michaud Levesque J, Richard S, et al. Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem. 2008;283:3006-10 pubmed
    ..Here we show that H3 tail binding effector proteins are indeed sensitive to H3R2 methylation and that PRMT6, not CARM1/PRMT4, is the primary methyltransferase acting on this site...
  3. Michaud Levesque J, Richard S. Thrombospondin-1 is a transcriptional repression target of PRMT6. J Biol Chem. 2009;284:21338-46 pubmed publisher
    Protein arginine methyltransferase 6 (PRMT6) is known to catalyze the generation of asymmetric dimethylarginine in polypeptides...
  4. Willemsen N, Hitchen E, Bodetti T, Apolloni A, Warrilow D, Piller S, et al. Protein methylation is required to maintain optimal HIV-1 infectivity. Retrovirology. 2006;3:92 pubmed
    ..Furthermore, our results also indicate that protein methylation regulates HIV-1 infectivity in a complex manner most likely involving the methylation of multiple viral or cellular proteins and/or multiple steps of replication. ..
  5. Miranda T, Webb K, Edberg D, Reeves R, Clarke S. Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. Biochem Biophys Res Commun. 2005;336:831-5 pubmed
    ..We demonstrate here that a GST fusion of protein arginine methyltransferase 6 (PRMT6) specifically methylates full-length recombinant HMGA1a protein in vitro...
  6. Invernizzi C, Xie B, Frankel F, Feldhammer M, Roy B, Richard S, et al. Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function. AIDS. 2007;21:795-805 pubmed
    ..As Tat is known to be asymmetrically arginine dimethylated by protein arginine methyltransferase 6 (PRMT6) in its ARM, we investigated whether NC could also act as a substrate for this enzyme...
  7. Guccione E, Bassi C, Casadio F, Martinato F, Cesaroni M, Schuchlautz H, et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature. 2007;449:933-7 pubmed
    ..Here we show that the arginine methyltransferase PRMT6 catalyses H3R2 di-methylation in vitro and controls global levels of H3R2me2a in vivo...
  8. Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, et al. PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev. 2007;21:3369-80 pubmed
    The arginine methyltransferase PRMT6 (protein arginine methyltransferase 6) has been shown recently to regulate DNA repair and gene expression...
  9. Kleinschmidt M, de Graaf P, van Teeffelen H, Timmers H. Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. PLoS ONE. 2012;7:e41446 pubmed publisher
    b>PRMT6 belongs to the family of Protein Arginine Methyltransferase (PRMT) enzymes that catalyze the methylation of guanidino nitrogens of arginine residues...
  10. Invernizzi C, Xie B, Richard S, Wainberg M. PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA. Retrovirology. 2006;3:93 pubmed
    ..Since Tat is known to be asymmetrically arginine dimethylated by protein arginine methyltransferase 6 (PRMT6) in its arginine rich motif, we investigated whether the Rev protein could act as a substrate for this enzyme...
  11. Sgarra R, Lee J, Tessari M, Altamura S, Spolaore B, Giancotti V, et al. The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem. 2006;281:3764-72 pubmed
    ..Here we show that the protein arginine methyltransferase PRMT6 specifically methylates HMGA1a protein both in vitro and in vivo...
  12. Johri M, Mishra R, Chhatbar C, Unni S, Singh S. Tits and bits of HIV Tat protein. Expert Opin Biol Ther. 2011;11:269-83 pubmed publisher
    ..This explains the massive death of immune cells due to bystander effect of HIV Tat protein among HIV-infected patients. ..
  13. Yan W, Liang Y, Zhang Q, Wang D, Lei M, Qu J, et al. Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis. EMBO Rep. 2018;19: pubmed publisher
    ..Protein arginine methyltransferase 6 (PRMT6) directly interacts with and methylates SIRT7 at R388 in vitro and in vivo R388 methylation ..
  14. Chan L, Zhou L, Ng K, Wong T, Lee T, Sharma R, et al. PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation. Cell Rep. 2018;25:690-701.e8 pubmed publisher
    ..We found protein methyltransferase 6 (PRMT6) to be frequently downregulated in hepatocellular carcinoma (HCC) and its expression to negatively correlate with ..
  15. Zhang H, Han C, Li T, Li N, Cao X. The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling. Cell Mol Immunol. 2018;: pubmed publisher
    ..We performed a functional screen of the nine mammalian PRMTs for regulators of IFN-β expression and found that PRMT6 inhibits the antiviral innate immune response. Viral infection also upregulated PRMT6 protein levels...
  16. Tu W, Liu Y, Shen Y, Yan Y, Wang X, Yang D, et al. Genome-wide Loci linked to non-obstructive azoospermia susceptibility may be independent of reduced sperm production in males with normozoospermia. Biol Reprod. 2015;92:41 pubmed publisher
    ..better understand the role of the variants in conferring NOA risk, we selected four GWAS loci (HLA-DRA rs3129878, PRMT6 rs12097821, SOX5 rs10842262, and PEX10 rs2477686) that were reported before 2014 to investigate their association ..
  17. Scaramuzzino C, Casci I, Parodi S, Lievens P, Polanco M, Milioto C, et al. Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Neuron. 2015;85:88-100 pubmed publisher
    ..We show here that protein arginine methyltransferase 6 (PRMT6) is a specific co-activator of normal and mutant AR and that the interaction of PRMT6 with AR is significantly ..
  18. Bouchard C, Sahu P, Meixner M, Nötzold R, Rust M, Kremmer E, et al. Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes. Cell Rep. 2018;24:3339-3352 pubmed publisher
    Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a). This mark has been reported to associate with silent genes...
  19. Wang C, Zhu Y, Chen J, Li X, Peng J, Chen J, et al. Crystal structure of arginine methyltransferase 6 from Trypanosoma brucei. PLoS ONE. 2014;9:e87267 pubmed publisher
    ..The T. brucei arginine methyltransferase 6 (TbPRMT6) is a type I arginine methyltransferase homologous to human PRMT6. In this study, we report the crystal structures of apo-TbPRMT6 and its complex with the reaction product S-..
  20. Bonnefond L, Stojko J, Mailliot J, Troffer Charlier N, Cura V, Wurtz J, et al. Functional insights from high resolution structures of mouse protein arginine methyltransferase 6. J Struct Biol. 2015;191:175-83 pubmed publisher
    b>PRMT6 is a protein arginine methyltransferase involved in transcriptional regulation, human immunodeficiency virus pathogenesis, DNA base excision repair, and cell cycle progression...
  21. Kramer J, Désor V, Brunst S, Wittmann S, Lausen J, Heering J, et al. A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity. Anal Biochem. 2018;547:7-13 pubmed publisher
    The protein arginine N-methyltransferase 6 (PRMT6) is overexpressed in a variety of different cancer types and plays a role in human immunodeficiency virus (HIV) infections...
  22. Xu H, Xu S, Mo K. [Transcription of protein arginine N-methyltransferase genes in mouse dorsal root ganglia following peripheral nerve injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1620-1625 pubmed
    ..enzyme family genes that were tissue?specifically expressed in the DRG, Prmt2 and Prmt3 showed the highest and Prmt6 showed the lowest basal expression...
  23. Zhao X, Zhang Y, Ni P, Wu Z, Yan Y, Li Y. Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene. J Biol Chem. 2016;291:402-12 pubmed publisher
    ..H3R2me2a, generated by protein arginine methyltransferase 6 (Prmt6), is a repressive mark...
  24. Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl B, et al. The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. Cell Rep. 2017;21:3390-3397 pubmed publisher
    ..Here, we show that PRMT6, a protein arginine methyltransferase responsible for asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a)..
  25. Thomas M, Sonntag E, Müller R, Schmidt S, Zielke B, Fossen T, et al. pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication. J Virol. 2015;89:9601-15 pubmed publisher
    ..mobility shift upon overexpression of the catalytically active protein arginine methyltransferase 6 (PRMT6)...
  26. Sivakumaran H, Lin M, Apolloni A, Cutillas V, Jin H, Li D, et al. Overexpression of PRMT6 does not suppress HIV-1 Tat transactivation in cells naturally lacking PRMT6. Virol J. 2013;10:207 pubmed publisher
    Protein arginine methyltransferase 6 (PRMT6) can methylate the HIV-1 Tat, Rev and nucleocapsid proteins in a manner that diminishes each of their functions in in vitro assays, and increases the stability of Tat in human cells...
  27. Luo M, Li Y, Guo H, Lin S, Chen J, Ma Q, et al. Protein Arginine Methyltransferase 6 Involved in Germ Cell Viability during Spermatogenesis and Down-Regulated by the Androgen Receptor. Int J Mol Sci. 2015;16:29467-81 pubmed publisher
    ..In this study, we found that the expression levels of Prmt6 mRNA and protein were significantly up-regulated in the testes of ARKO mice compared to wild type (WT) mice...
  28. Nakakido M, Deng Z, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R. PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents. Oncotarget. 2015;6:30957-67 pubmed publisher
    ..Here we demonstrate that protein arginine methyltransferase 6 (PRMT6) methylates p21 at arginine 156 and promotes phosphorylation of threonine 145 on p21, resulting in the increase of ..
  29. Fulcher A, Sivakumaran H, Jin H, Rawle D, Harrich D, Jans D. The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention. Biochim Biophys Acta. 2016;1863:254-62 pubmed publisher
    ..can be modulated by specific methylation, whereby overexpression of active but not catalytically inactive PRMT6 methyltransferase specifically leads to exclusion of Tat from the nucleolus...
  30. Tsai K, Lee W, Chen W, Chen B, Chen K, Hsiao T, et al. Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF-?B in glomerular mesangial cells. J Cell Biochem. 2017;: pubmed publisher
    ..expressions of enzymes central to cellular methylation reactions, especially protein arginine methyltransferase 6 (PRMT6) in MES-13 cells...
  31. He X, Li T, Kang N, Zeng H, Ren S, Zong D, et al. The protective effect of PRMT6 overexpression on cigarette smoke extract-induced murine emphysema model. Int J Chron Obstruct Pulmon Dis. 2017;12:3245-3254 pubmed publisher
    ..Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that specially catalyzes dimethylation of R2 in histone H3 (H3R2me2a)...
  32. He J, Kelly T, Zhao Q, Li H, Huang J, Wang L, et al. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. Circ Cardiovasc Genet. 2013;6:598-607 pubmed publisher
    ..The meta-analyses identified 8 novel loci for BP phenotypes, which physically mapped in or near PRMT6 (P=7.29 × 10(-9)), CDCA7 (P=3.57 × 10(-8)), PIBF1 (P=1.78 × 10(-9)), ARL4C (P=1.86 × 10(-8)), IRAK1BP1 (P=1...
  33. Limm K, Ott C, Wallner S, Mueller D, Oefner P, Hellerbrand C, et al. Deregulation of protein methylation in melanoma. Eur J Cancer. 2013;49:1305-13 pubmed publisher
    ..Our findings demonstrate that expression of PRMT4/CARM1 and PRMT6 is deregulated in melanoma, whereas expression of the remaining PRMTs stays unchanged...
  34. Lee Y, Ma H, Tan T, Ng S, Soong R, Mori S, et al. Protein arginine methyltransferase 6 regulates embryonic stem cell identity. Stem Cells Dev. 2012;21:2613-22 pubmed publisher
    ..Recently, it has been reported that PRMT6-mediated di-methylation of histone H3 at arginine 2 (H3R2me2) can antagonize tri-methylation of histone H3 at ..
  35. Herglotz J, Kuvardina O, Kolodziej S, Kumar A, Hussong H, Grez M, et al. Histone arginine methylation keeps RUNX1 target genes in an intermediate state. Oncogene. 2013;32:2565-75 pubmed publisher
    ..Here, we identify protein arginine methyltransferase 6 (PRMT6) as a central functional component of a RUNX1 corepressor complex containing Sin3a and HDAC1 in human ..
  36. Dowhan D, Harrison M, Eriksson N, Bailey P, Pearen M, Fuller P, et al. Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes. Endocr Relat Cancer. 2012;19:509-26 pubmed publisher
    Protein arginine methyltransferase-6 (PRMT6) regulates steroid-dependent transcription and alternative splicing and is implicated in endocrine system development and function, cell death, cell cycle, gene expression and cancer...
  37. Wu H, Zheng W, Eram M, Vhuiyan M, Dong A, Zeng H, et al. Structural basis of arginine asymmetrical dimethylation by PRMT6. Biochem J. 2016;473:3049-63 pubmed publisher
    b>PRMT6 is a type I protein arginine methyltransferase, generating the asymmetric dimethylarginine mark on proteins such as histone H3R2...
  38. Wang X, Huang Y, Zhao J, Zhang Y, Lu J, Huang B. Suppression of PRMT6-mediated arginine methylation of p16 protein potentiates its ability to arrest A549 cell proliferation. Int J Biochem Cell Biol. 2012;44:2333-41 pubmed publisher
    ..Additionally, we determined that the protein arginine methyltransferase 6 (PRMT6) was responsible for the p16 arginine methylation...
  39. Victoriano A, Okamoto T. Transcriptional control of HIV replication by multiple modulators and their implication for a novel antiviral therapy. AIDS Res Hum Retroviruses. 2012;28:125-38 pubmed publisher
    ..We include recent findings on chromatin remodeling toward HIV transcription and its therapeutic implication is also discussed. The current status of small-molecular-weight compounds that affect HIV transcription is also described. ..
  40. Casadio F, Lu X, Pollock S, LeRoy G, Garcia B, Muir T, et al. H3R42me2a is a histone modification with positive transcriptional effects. Proc Natl Acad Sci U S A. 2013;110:14894-9 pubmed publisher
    ..the methyltransferases coactivator arginine methyltransferase 1 (CARM1) and protein arginine methyltransferase 6 (PRMT6) in vitro and in vivo, and we demonstrate that methylation of H3R42 stimulates transcription in vitro from ..
  41. Stavride P, Arampatzi P, Papamatheakis J. Differential regulation of MHCII genes by PRMT6, via an AT-hook motif of RFX5. Mol Immunol. 2013;56:390-8 pubmed publisher
    ..Furthermore, PRMT6, an arginine methyltransferase known to methylate AT-hook motifs, downregulates the expression of HLA-DQ, but not ..
  42. Lo Sardo A, Altamura S, Pegoraro S, Maurizio E, Sgarra R, Manfioletti G. Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6). PLoS ONE. 2013;8:e53750 pubmed publisher
    b>PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis...
  43. Wheeler E, Huang N, Bochukova E, Keogh J, Lindsay S, Garg S, et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat Genet. 2013;45:513-7 pubmed publisher
    ..0001). Integrative gene network pathway analysis of rare deletions indicated enrichment of genes affecting G protein-coupled receptors (GPCRs) involved in the neuronal regulation of energy homeostasis. ..
  44. Kang N, Chen P, Chen Y, Zeng H, He X, Zhu Y. PRMT6 mediates CSE induced inflammation and apoptosis. Int Immunopharmacol. 2015;24:95-101 pubmed publisher
    ..Arginine methyltransferase (PRMT6) catalyzes the asymmetric di-methylation of histone H3 arginine 2 (H3R2me2a) to control global level transcription...
  45. Coviello A, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, et al. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet. 2012;8:e1002805 pubmed publisher
    ..Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p = 1.8 × 10(-106)), PRMT6 (rs17496332, 1p13.3, p = 1.4 × 10(-11)), GCKR (rs780093, 2p23.3, p = 2...
  46. Zhao X, Zhou D, Liu Y, Li C, Zhao X, Li Y, et al. Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway. Mol Med Rep. 2018;17:147-157 pubmed publisher
    ..LNCaP cells were transfected with either a protein arginine methyltransferase 6 (PRMT6) overexpression plasmid or PRMT6 small interfering (si)RNA...
  47. Winter D, Hart Smith G, Wilkins M. Characterization of Protein Methyltransferases Rkm1, Rkm4, Efm4, Efm7, Set5 and Hmt1 Reveals Extensive Post-Translational Modification. J Mol Biol. 2018;430:102-118 pubmed publisher
    ..Finally, we compared PTMs on Hmt1 with those on its human homologs PRMT1, PRMT3, CARM1, PRMT6 and PRMT8...
  48. Damez Werno D, Sun H, Scobie K, Shao N, Rabkin J, Dias C, et al. Histone arginine methylation in cocaine action in the nucleus accumbens. Proc Natl Acad Sci U S A. 2016;113:9623-8 pubmed publisher
    ..Here we show that protein-R-methyltransferase-6 (PRMT6) and its associated histone mark, asymmetric dimethylation of R2 on histone H3 (H3R2me2a), are decreased in the ..
  49. Stein C, Nötzold R, Riedl S, Bouchard C, Bauer U. The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression. PLoS ONE. 2016;11:e0148892 pubmed publisher
    Protein arginine methyltransferase 6 (PRMT6) catalyses asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a), which has been shown to impede the deposition of histone H3 lysine 4 trimethylation (H3K4me3) by blocking the binding ..
  50. Sun Y, Chung H, Woo A, Lin V. Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor ? via distinct mechanisms. Biochim Biophys Acta. 2014;1843:2067-78 pubmed publisher
    Recent studies reported that protein arginine methyltransferase 6 (PRMT6) enhances estrogen-induced activity of estrogen receptor ? (ER?) and dysfunction of PRMT6 is associated with overall better survival for ER?-positive breast cancer ..
  51. Herkt S, Kuvardina O, Herglotz J, Schneider L, Meyer A, Pommerenke C, et al. Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34+ progenitor cells. Haematologica. 2018;103:18-29 pubmed publisher
    ..An example is the association of the transcription factor RUNX1 with protein arginine methyltransferase 6 (PRMT6) at the megakaryocytic/erythroid bifurcation...
  52. Kim N, Kim S, Seo D, Han J, Kim Y. PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion. Biochem Biophys Res Commun. 2013;432:60-5 pubmed publisher
    In this study, we investigate the molecular mechanism by which protein arginine methyltransferase 6 (PRMT6) exerts anti-invasiveness effect against breast cancer cells and prostate cancer cells...
  53. Almeida Rios D, Graça I, Vieira F, Ramalho Carvalho J, Pereira Silva E, Martins A, et al. Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer. Oncotarget. 2016;7:53018-53028 pubmed publisher
    ..Herein we aimed to uncover the potential oncogenic role of PRMT6 in prostate carcinogenesis. PRMT6 overexpression was confirmed in PCa, at transcript and protein level...
  54. Loo S, Shtir C, Doyle A, Mick E, McGough J, McCracken J, et al. Genome-wide association study of intelligence: additive effects of novel brain expressed genes. J Am Acad Child Adolesc Psychiatry. 2012;51:432-440.e2 pubmed publisher
    ..The precise mechanisms of these loci in relation to determining individual differences in general cognitive ability require further investigation. ..
  55. McLaren M, Marsh K, Cochrane A. Modulating HIV-1 RNA processing and utilization. Front Biosci. 2008;13:5693-707 pubmed
    ..The observations made underline the multiple fate decisions that must be made at each stage of the viral RNA metabolic pathway and highlight potential new avenues for controlling HIV-1 replication. ..
  56. Singhroy D, Mespl de T, Sabbah A, Quashie P, Falgueyret J, Wainberg M. Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity. Retrovirology. 2013;10:73 pubmed publisher
    Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that methylates arginine residues on histones and transcription factors...
  57. Huang J, Cardamone M, JOHNSON H, Neault M, Chan M, Floyd Z, et al. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015;290:19044-54 pubmed publisher
    ..factor TBL1 is required to protect GPS2 from degradation, with methylation of GPS2 by arginine methyltransferase PRMT6 regulating the interaction with TBL1 and inhibiting proteasome-dependent degradation...
  58. Wainberg M, Jeang K. 25 years of HIV-1 research - progress and perspectives. BMC Med. 2008;6:31 pubmed publisher
    ..Here, we summarize, in brief, advances that have been achieved and provide some perspectives on future challenges. ..
  59. Lakowski T, Frankel A. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Biochem J. 2009;421:253-61 pubmed publisher
    ..Although PRMT2 activity is substantially lower than PRMT1 in vitro, the fact that both enzymes selectively methylate histone H4 suggest that PRMT2, like PRMT1, may act as a transcription co-activator through this modification. ..
  60. Campbell M, Chang P, Huerta S, Izumiya C, Davis R, Tepper C, et al. Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. J Biol Chem. 2012;287:5806-18 pubmed publisher
    ..These results suggest that residue 20 is important for modulation of a subset of LANA functions and properties of this residue, including the hydrophobic character induced by arginine methylation, may contribute to the observed effects. ..