PRMT5

Summary

Gene Symbol: PRMT5
Description: protein arginine methyltransferase 5
Alias: HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs, protein arginine N-methyltransferase 5, 72 kDa ICln-binding protein, HMT1 hnRNP methyltransferase-like 5, SKB1 homolog, histone-arginine N-methyltransferase PRMT5, jak-binding protein 1, shk1 kinase-binding protein 1 homolog
Species: human
Products:     PRMT5

Top Publications

  1. Le Guezennec X, Vermeulen M, Brinkman A, Hoeijmakers W, Cohen A, Lasonder E, et al. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol Cell Biol. 2006;26:843-51 pubmed
    ..We identified DOC-1, a putative tumor suppressor, as a novel core subunit of MBD2/NuRD as well as MBD3/NuRD. PRMT5 and its cofactor MEP50 were identified as specific MBD2/NuRD interactors...
  2. Aggarwal P, Vaites L, Kim J, Mellert H, Gurung B, Nakagawa H, et al. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 2010;18:329-40 pubmed publisher
    ..work reveals a molecular relationship between cyclin D1/CDK4 kinase and protein arginine methyltransferase 5 (PRMT5), an enzyme associated with histone methylation and transcriptional repression...
  3. Andreu Pérez P, Esteve Puig R, de Torre Minguela C, López Fauqued M, Bech Serra J, Tenbaum S, et al. Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. Sci Signal. 2011;4:ra58 pubmed publisher
    ..in ERK1/2 phosphorylation depended on methylation of RAF proteins by protein arginine methyltransferase 5 (PRMT5)...
  4. Pal S, Vishwanath S, Erdjument Bromage H, Tempst P, SIF S. Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol. 2004;24:9630-45 pubmed
    ..We have recently shown that PRMT5 can interact with flag-tagged BRG1- and hBRM-based hSWI/SNF chromatin remodelers and that both complexes can ..
  5. Wei H, Wang B, Miyagi M, She Y, Gopalan B, Huang D, et al. PRMT5 dimethylates R30 of the p65 subunit to activate NF-?B. Proc Natl Acad Sci U S A. 2013;110:13516-21 pubmed publisher
    ..to IL-1?, the p65 subunit of NF-?B is dimethylated on arginine 30 (R30) by protein-arginine methyltransferase 5 (PRMT5)...
  6. Fabbrizio E, El Messaoudi S, Polanowska J, Paul C, Cook J, Lee J, et al. Negative regulation of transcription by the type II arginine methyltransferase PRMT5. EMBO Rep. 2002;3:641-5 pubmed
    ..Purification of native CERC reveals the presence of the type II arginine methyltransferase PRMT5, which can mono- or symetrically dimethylate arginine residues in proteins...
  7. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham D. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J Biol Chem. 1998;273:10811-4 pubmed
    ..The protein is homologous to the yeast Skb1 protein. Skb1 interacts with Shk1, a homolog of the p21(Cdc42/Rac)-activated protein kinases (PAKs)...
  8. Friesen W, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, et al. A novel WD repeat protein component of the methylosome binds Sm proteins. J Biol Chem. 2002;277:8243-7 pubmed
    ..S) protein arginine methyltransferase complex, termed the methylosome, that contains the methyltransferase JBP1 (PRMT5) and the pICln protein...
  9. Kwak Y, Guo J, Prajapati S, Park K, Surabhi R, Miller B, et al. Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties. Mol Cell. 2003;11:1055-66 pubmed
    ..to demonstrate that SPT5 was specifically associated with the protein arginine methyltransferases PRMT1 and PRMT5 and that SPT5 methylation regulated its interaction with RNA polymerase II...

More Information

Publications72

  1. Gu Z, Li Y, Lee P, Liu T, Wan C, Wang Z. Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells. PLoS ONE. 2012;7:e44033 pubmed publisher
    Protein arginine methyltransferase 5 (PRMT5) plays multiple roles in a large number of cellular processes, and its subcellular localization is dynamically regulated during mouse development and cellular differentiation...
  2. Pal S, Yun R, Datta A, Lacomis L, Erdjument Bromage H, Kumar J, et al. mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol Cell Biol. 2003;23:7475-87 pubmed
    ..Here we show that the type II arginine-specific methyltransferase PRMT5, which is involved in cyclin E repression, can be found in association with Brg1 and hBrm-based hSWI/SNF complexes...
  3. Wei T, Juan C, Hisa J, Su L, Lee Y, Chou H, et al. Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci. 2012;103:1640-50 pubmed publisher
    Increasing evidence suggests that PRMT5, a protein arginine methyltransferase, is involved in tumorigenesis. However, no systematic research has demonstrated the cell-transforming activity of PRMT5...
  4. Karkhanis V, Hu Y, Baiocchi R, Imbalzano A, SIF S. Versatility of PRMT5-induced methylation in growth control and development. Trends Biochem Sci. 2011;36:633-41 pubmed publisher
    ..Unlike other PRMTs, PRMT5 works in concert with a variety of cellular proteins including ATP-dependent chromatin remodelers and co-..
  5. Wang L, Pal S, SIF S. Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. Mol Cell Biol. 2008;28:6262-77 pubmed publisher
    ..The human SWI/SNF-associated PRMT5 is involved in the transcriptional repression of target genes by directly methylating H3R8 and H4R3...
  6. Pesiridis G, Diamond E, Van Duyne G. Role of pICLn in methylation of Sm proteins by PRMT5. J Biol Chem. 2009;284:21347-59 pubmed publisher
    ..pICln also interacts with PRMT5, the enzyme responsible for generating symmetric dimethylarginine modifications on the carboxyl-terminal regions ..
  7. Maloney A, Clarke P, Naaby Hansen S, Stein R, Koopman J, Akpan A, et al. Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Cancer Res. 2007;67:3239-53 pubmed
    ..1 was increased, and expression of the histone acetyltransferase 1 and the histone arginine methyltransferase PRMT5 was decreased by 17AAG. PRMT5 was shown to be a novel HSP90-binding partner and potential client protein...
  8. Chari A, Golas M, Klingenhäger M, Neuenkirchen N, Sander B, Englbrecht C, et al. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell. 2008;135:497-509 pubmed publisher
    ..A hallmark of these particles is a ring-shaped core domain generated by the binding of Sm proteins onto snRNA. PRMT5 and SMN complexes mediate the formation of the core domain in vivo...
  9. Antonysamy S, Bonday Z, Campbell R, Doyle B, Druzina Z, Gheyi T, et al. Crystal structure of the human PRMT5:MEP50 complex. Proc Natl Acad Sci U S A. 2012;109:17960-5 pubmed publisher
    ..b>PRMT5 symmetrically di-methylates the two-terminal ?-guanidino nitrogens of arginine residues on substrate proteins...
  10. Gu Z, Gao S, Zhang F, Wang Z, Ma W, Davis R, et al. Protein arginine methyltransferase 5 is essential for growth of lung cancer cells. Biochem J. 2012;446:235-41 pubmed publisher
    b>PRMT5 (protein arginine methyltransferase 5) is an enzyme that catalyses transfer of methyl groups from S-adenosyl methionine to the arginine residues of histones or non-histone proteins and is involved in a variety of cellular processes...
  11. Cesaro E, De Cegli R, Medugno L, Florio F, Grosso M, Lupo A, et al. The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene. J Biol Chem. 2009;284:32321-30 pubmed publisher
    ..In this work, by co-immunoprecipitation experiments, we demonstrate that PRMT5, a type II protein arginine methyltransferase that monomethylates and symmetrically dimethylates arginine residues,..
  12. Eckert D, Biermann K, Nettersheim D, Gillis A, Steger K, Jack H, et al. Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. BMC Dev Biol. 2008;8:106 pubmed publisher
    ..In murine PGCs, expression and interaction of Blimp1 and Prmt5 results in arginine 3 dimethylation of histone H2A and H4...
  13. Gonsalvez G, Tian L, Ospina J, Boisvert F, Lamond A, Matera A. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. J Cell Biol. 2007;178:733-40 pubmed
    ..Several lines of evidence suggest that the methyltransferase protein arginine methyltransferase 5 (PRMT5) is responsible for sDMA modification of Sm proteins...
  14. Cho E, Zheng S, Munro S, Liu G, Carr S, Moehlenbrink J, et al. Arginine methylation controls growth regulation by E2F-1. EMBO J. 2012;31:1785-97 pubmed publisher
    ..We show here that E2F-1 is directly methylated by PRMT5 (protein arginine methyltransferase 5), and that arginine methylation is responsible for regulating its ..
  15. Pal S, Baiocchi R, Byrd J, Grever M, Jacob S, SIF S. Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. EMBO J. 2007;26:3558-69 pubmed
    Protein arginine methyltransferase PRMT5 interacts with human SWI/SNF complexes and methylates histones H3R8 and H4R3...
  16. Zhou Z, Sun X, Zou Z, Sun L, Zhang T, Guo S, et al. PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130. Cell Res. 2010;20:1023-33 pubmed publisher
    ..Here, we show that the protein arginine methyltransferase 5 (PRMT5) localizes to the GA and forms complexes with several components involved in GA ribbon formation and vesicle ..
  17. Pollack B, Kotenko S, He W, Izotova L, Barnoski B, Pestka S. The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem. 1999;274:31531-42 pubmed
    ..We demonstrate that this protein is a protein methyltransferase. This protein, designated JBP1 (Jak-binding protein 1), and its homologues contain motifs conserved among protein methyltransferases...
  18. Guderian G, Peter C, Wiesner J, Sickmann A, Schulze Osthoff K, Fischer U, et al. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. J Biol Chem. 2011;286:1976-86 pubmed publisher
    ..The human PRMT5 complex consists of PRMT5, WD45/MEP50 (WD repeat domain 45/methylosome protein 50), and pICln and catalyzes the ..
  19. Liang J, Wang Z, Chiriboga L, Greco M, Shapiro E, Huang H, et al. The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. J Urol. 2007;177:1918-22 pubmed
    ..Further studies are needed to confirm the functional relevance of these findings. ..
  20. Liu F, Zhao X, Perna F, Wang L, Koppikar P, Abdel Wahab O, et al. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell. 2011;19:283-94 pubmed publisher
    ..While examining the interaction between JAK2 and PRMT5, an arginine methyltransferase originally identified as JAK-binding protein 1, we found that JAK2V617F (and ..
  21. Amente S, Napolitano G, Licciardo P, Monti M, Pucci P, Lania L, et al. Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. FEBS Lett. 2005;579:683-9 pubmed
    ..We identified four proteins: RPB2 subunit of the RNAPII, the nuclear kinase, NDR1, the methyltransferase PRMT5 and the enhancer of rudimentary homologue (ERH) proteins...
  22. Rho J, Choi S, Seong Y, Cho W, Kim S, Im D. Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. J Biol Chem. 2001;276:11393-401 pubmed publisher
    We found that JBP1, known as a human homolog (Skb1Hs) of Skb1 of fission yeast, interacts with NS3 of the hepatitis C virus in a yeast two-hybrid screen...
  23. Kanade S, Eckert R. Protein arginine methyltransferase 5 (PRMT5) signaling suppresses protein kinase C?- and p38?-dependent signaling and keratinocyte differentiation. J Biol Chem. 2012;287:7313-23 pubmed publisher
    ..In this study we use affinity purification and mass spectrometry to identify protein arginine methyltransferase 5 (PRMT5) as part of the p38? signaling complex...
  24. Hosohata K, Li P, Hosohata Y, Qin J, Roeder R, Wang Z. Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. Mol Cell Biol. 2003;23:7019-29 pubmed
    ..p44 expression is dramatically enhanced in prostate cancer tissue compared with adjacent benign prostate tissue. ..
  25. Ren J, Wang Y, Liang Y, Zhang Y, Bao S, Xu Z. Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. J Biol Chem. 2010;285:12695-705 pubmed publisher
    ..that ribosomal protein s10 (RPS10) is a novel substrate of an oncoprotein, protein-arginine methyltransferase 5 (PRMT5). We show that PRMT5 interacts with RPS10 and catalyzes its methylation at the Arg(158) and Arg(160) residues...
  26. Brahms H, Meheus L, de Brabandere V, Fischer U, Luhrmann R. Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein. RNA. 2001;7:1531-42 pubmed
    ..Our demonstration of sDMAs in LSm4 suggests additional functions of sDMAs in tri-UsnRNP biogenesis and mRNA decay. Our findings also have interesting implications for the understanding of the aetiology of spinal muscular atrophy (SMA). ..
  27. Ancelin K, Lange U, Hajkova P, Schneider R, Bannister A, Kouzarides T, et al. Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol. 2006;8:623-30 pubmed
    ..Here, we show that Blimp1 has a novel interaction with Prmt5, an arginine-specific histone methyltransferase, which mediates symmetrical dimethylation of arginine 3 on histone ..
  28. Jansson M, Durant S, Cho E, Sheahan S, Edelmann M, Kessler B, et al. Arginine methylation regulates the p53 response. Nat Cell Biol. 2008;10:1431-9 pubmed publisher
    ..Furthermore, PRMT5 depletion triggers p53-dependent apoptosis...
  29. Teng Y, Girvan A, Casson L, Pierce W, Qian M, Thomas S, et al. AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin. Cancer Res. 2007;67:10491-500 pubmed
    ..Here, we report that protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes the formation of symmetrical dimethylarginine (sDMA), is a nucleolin-associated protein ..
  30. Richard S, Morel M, Cleroux P. Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5). Biochem J. 2005;388:379-86 pubmed
    ..with small interfering RNAs against the major PRMT (protein arginine methyltransferases) that generates sDMA (PRMT5)...
  31. Rank G, Cerruti L, Simpson R, Moritz R, Jane S, Zhao Q. Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood. 2010;116:1585-92 pubmed publisher
    ..that symmetric methylation of histone H4 Arginine 3 (H4R3me2s) by the protein arginine methyltransferase PRMT5 is required for recruitment of the DNA methyltransferase DNMT3A to the gamma-promoter, and subsequent DNA ..
  32. Powers M, Fay M, Factor R, Welm A, Ullman K. Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4. Cancer Res. 2011;71:5579-87 pubmed publisher
    ..Here, we explore the significance of PDCD4 in breast cancer and identify protein arginine methyltransferase 5 (PRMT5) as a cofactor that radically alters PDCD4 function...
  33. Meister G, Eggert C, Buhler D, Brahms H, Kambach C, Fischer U. Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln. Curr Biol. 2001;11:1990-4 pubmed
    ..we provide evidence that the previously described pICln-complex, consisting of Sm proteins, the methyltransferase PRMT5, pICln, and two novel factors, catalyzes the sDMA modification of Sm proteins...
  34. Zhao Q, Rank G, Tan Y, Li H, Moritz R, Simpson R, et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 2009;16:304-311 pubmed publisher
    ..that symmetric methylation of histone H4 arginine 3 (H4R3me2s) by the protein arginine methyltransferase PRMT5 is required for subsequent DNA methylation...
  35. Hou Z, Peng H, Ayyanathan K, Yan K, Langer E, Longmore G, et al. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol. 2008;28:3198-207 pubmed publisher
    ..Here, we describe the identification of the protein arginine methyltransferase 5 (PRMT5) as an effector recruited to SNAIL through an interaction with AJUBA that functions to repress the SNAIL target ..
  36. Lacroix M, El Messaoudi S, Rodier G, Le Cam A, Sardet C, Fabbrizio E. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. EMBO Rep. 2008;9:452-8 pubmed publisher
    Protein arginine methyltransferase 5 (PRMT5) targets nuclear and cytoplasmic proteins. Here, we identified a nuclear protein, called cooperator of PRMT5 (COPR5), involved in the nuclear functions of PRMT5...
  37. Bao X, Zhao S, Liu T, Liu Y, Liu Y, Yang X. Overexpression of PRMT5 promotes tumor cell growth and is associated with poor disease prognosis in epithelial ovarian cancer. J Histochem Cytochem. 2013;61:206-17 pubmed publisher
    b>PRMT5 has been reported to be involved in the processes of tumor progression at various steps. The aim of this study was to examine the role of PRMT5 in epithelial ovarian cancer (EOC)...
  38. Bruns A, Grothe C, Claus P. Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5. Biol Chem. 2009;390:59-65 pubmed publisher
    ..For this assembly, Sm-proteins methylated by protein arginine methyltransferase 5 (PRMT5) are required...
  39. Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers L, et al. Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing. J Biol Chem. 2013;288:35534-47 pubmed publisher
    ..an essential role in tumorigenesis, and enhanced expression of the type II protein arginine methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been associated with increased cell proliferation and survival...
  40. Friesen W, Paushkin S, Wyce A, Massenet S, Pesiridis G, Van Duyne G, et al. The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. Mol Cell Biol. 2001;21:8289-300 pubmed
    ..SmD3 associate with a 20S methyltransferase complex, termed the methylosome, that contains the methyltransferase JBP1 and a JBP1-interacting protein, pICln...
  41. Jiang W, Roemer M, Newsham I. The tumor suppressor DAL-1/4.1B modulates protein arginine N-methyltransferase 5 activity in a substrate-specific manner. Biochem Biophys Res Commun. 2005;329:522-30 pubmed
    ..In this study, we assessed the impact of DAL-1/4.1B binding on the activity of another family member, PRMT5, both in vitro and in cells. In contrast to PRMT3, DAL-1/4...
  42. Tee W, Pardo M, Theunissen T, Yu L, Choudhary J, Hajkova P, et al. Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency. Genes Dev. 2010;24:2772-7 pubmed publisher
    b>Prmt5, an arginine methyltransferase, has multiple roles in germ cells, and possibly in pluripotency. Here we show that loss of Prmt5 function is early embryonic-lethal due to the abrogation of pluripotent cells in blastocysts...
  43. Miranda T, Khusial P, Cook J, Lee J, Gunderson S, Pestka S, et al. Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus. Biochem Biophys Res Commun. 2004;323:382-7 pubmed
    ..In reactions in which Sm D1 or Sm D3 was methylated in vitro with a hemagglutinin-tagged PRMT5 purified from HeLa cells, we detected both symmetric omega-NG,NG'-dimethylarginine and asymmetric omega-NG,NG-..
  44. Nicholas C, Yang J, Peters S, Bill M, Baiocchi R, Yan F, et al. PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.). PLoS ONE. 2013;8:e74710 pubmed publisher
    Protein arginine methyltransferase-5 (PRMT5) is a Type II arginine methyltransferase that regulates various cellular functions. We hypothesized that PRMT5 plays a role in regulating the growth of human melanoma cells...
  45. Chen M, Qu X, Zhang Z, Wu H, Qin X, Li F, et al. Cross-talk between Arg methylation and Ser phosphorylation modulates apoptosis signal-regulating kinase 1 activation in endothelial cells. Mol Biol Cell. 2016;27:1358-66 pubmed publisher
    We describe a novel functional interaction between ASK1 and PRMT5. We show that PRMT5 interacts with and methylates ASK1 at arginine residue 89 and thereby negatively regulates its activity by promoting the interaction between ASK1 and ..
  46. Ghufran M, Ghosh K, Kanade S. Aflatoxin B1 induced upregulation of protein arginine methyltransferase 5 in human cell lines. Toxicon. 2016;119:117-21 pubmed publisher
    ..This is the first report showing the induction of epigenetic regulatory protein, protein arginine methyltransferase 5 upon aflatoxin B1 treatment. Further study is required to establish the detailed pathway of PRMT5 induction.
  47. Fu X. Exploiting the Hidden Treasure of Detained Introns. Cancer Cell. 2017;32:393-395 pubmed publisher
    ..In this issue of Cancer Cell, Braun et al. report that the arginine methyltransferase PRMT5 is critical for tumor cell proliferation by regulating numerous detained introns.
  48. Li G, Gao Y, Cui L, Wu L, Yang X, Chen J. Anguilla japonica lectin 1 delivery through adenovirus vector induces apoptotic cancer cell death through interaction with PRMT5. J Gene Med. 2016;18:65-74 pubmed publisher
    ..expressed lectins elicited cytotoxicity to cancer cells, utilizing protein arginine methyltransferase 5 (PRMT5) as a common binding target...
  49. Gruss O, Meduri R, Schilling M, Fischer U. UsnRNP biogenesis: mechanisms and regulation. Chromosoma. 2017;126:577-593 pubmed publisher
    ..UsnRNPs are assembled by factors united in protein arginine methyltransferase 5 (PRMT5)- and survival motor neuron (SMN)-complexes, which act sequentially in the UsnRNP production line...
  50. Krapivinsky G, Krapivinsky L, Renthal N, Santa Cruz A, Manasian Y, Clapham D. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A. 2017;114:E7092-E7100 pubmed publisher
    ..TRPM6-cleaved kinases (M6CKs) bind subunits of the protein arginine methyltransferase 5 (PRMT5) molecular complex that make important epigenetic modifications by methylating histone arginine residues...
  51. Zakrzewicz D, Didiasova M, Kruger M, Giaimo B, Borggrefe T, Mieth M, et al. Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1816-1827 pubmed publisher
    ..Protein arginine methyltransferase 5 (PRMT5) was identified to be responsible for Eno-1 methylation...
  52. Gkountela S, Li Z, Chin C, Lee S, Clark A. PRMT5 is required for human embryonic stem cell proliferation but not pluripotency. Stem Cell Rev. 2014;10:230-9 pubmed publisher
    ..In the current study we evaluated the role of Protein arginine methyltransferase 5 (PRMT5) in human ESC (hESC) self-renewal and pluripotency given its critical role in safeguarding mouse ESC pluripotency...
  53. Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K. Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. Biochem Biophys Res Commun. 2006;345:1051-8 pubmed
    ..H2A selectively among core histones, and mediates transcriptional repression of protein arginine methyltransferase PRMT5, which is known to methylate H2A and H4...
  54. Quan X, Yue W, Luo Y, Cao J, Wang H, Wang Y, et al. The protein arginine methyltransferase PRMT5 regulates Aβ-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimer's disease. J Neurochem. 2015;134:969-77 pubmed publisher
    The protein arginine methyltransferase 5 (PRMT5) controls cell growth and apoptosis by catalyzing mono and symmetric dimethylation of arginine residues. In human brain tissue, PRMT5 is predominantly expressed in neuronal cells...
  55. Fronz K, Otto S, Kölbel K, Kuhn U, Friedrich H, Schierhorn A, et al. Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J Biol Chem. 2008;283:20408-20 pubmed publisher
    ..Thus, arginine methylation might be relevant for oculopharyngeal muscular dystrophy. However, in two different types of assays we have been unable to detect any effect of arginine methylation on the aggregation of bovine PABPN1. ..
  56. Xu Z, He Y, Ju J, Rank G, Cerruti L, Ma C, et al. The role of WDR5 in silencing human fetal globin gene expression. Haematologica. 2012;97:1632-40 pubmed publisher
    ..We found that WDR5 interacted with protein arginine methyltransferase 5 (PRMT5), a known repressor of ?-globin gene expression, and was essential for generating tri-methylated H3K4 (H3K4me3) at ..
  57. Campbell M, Chang P, Huerta S, Izumiya C, Davis R, Tepper C, et al. Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. J Biol Chem. 2012;287:5806-18 pubmed publisher
    ..These results suggest that residue 20 is important for modulation of a subset of LANA functions and properties of this residue, including the hydrophobic character induced by arginine methylation, may contribute to the observed effects. ..
  58. Paul C, Sardet C, Fabbrizio E. The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. Cell Death Differ. 2012;19:900-8 pubmed publisher
    ..Recently, it has been reported that the Protein aRginine Methyl Transferase PRMT5 modulates the early phase of induction of MYOG expression...
  59. Rengasamy M, Zhang F, Vashisht A, Song W, Aguilo F, Sun Y, et al. The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer. Nucleic Acids Res. 2017;45:11106-11120 pubmed publisher
    We observed overexpression and increased intra-nuclear accumulation of the PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells...
  60. Webb L, Amici S, Jablonski K, Savardekar H, Panfil A, Li L, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol. 2017;198:1439-1451 pubmed publisher
    ..b>PRMT5 is the main PRMT responsible for symmetric dimethylation of arginine residues of histones and other proteins...
  61. Wu Y, Wang Z, Zhang J, Ling R. Elevated expression of protein arginine methyltransferase 5 predicts the poor prognosis of breast cancer. Tumour Biol. 2017;39:1010428317695917 pubmed publisher
    ..In conclusion, we proposed that protein arginine methyltransferase 5 is an independent prognostic biomarker for breast cancer, and targeting protein arginine methyltransferase 5 might be a promising strategy for breast cancer treatment. ..
  62. Yang H, Zhao X, Zhao L, Liu L, Li J, Jia W, et al. PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma. Oncotarget. 2016;7:72131-72147 pubmed publisher
    ..Here, we report that upon glucose induction, protein arginine methyltransferase 5 (PRMT5) exerts a profound effect on the G1-S cell cycle progression via directly interacting with cyclin dependent kinase ..
  63. Dacwag C, Bedford M, SIF S, Imbalzano A. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol. 2009;29:1909-21 pubmed publisher
    ..We previously demonstrated that the class II arginine methyltransferase Prmt5 was required for skeletal muscle differentiation at the early stages of myogenesis (C. S. Dacwag, Y. Ohkawa, S...