Gene Symbol: PRMT1
Description: protein arginine methyltransferase 1
Alias: ANM1, HCP1, HRMT1L2, IR1B4, protein arginine N-methyltransferase 1, HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2, heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2, histone-arginine N-methyltransferase PRMT1, interferon receptor 1-bound protein 4
Species: human
Products:     PRMT1

Top Publications

  1. Araya N, Hiraga H, Kako K, Arao Y, Kato S, Fukamizu A. Transcriptional down-regulation through nuclear exclusion of EWS methylated by PRMT1. Biochem Biophys Res Commun. 2005;329:653-60 pubmed
    ..In this study, we found that a protein arginine methyltransferase, PRMT1, physically interacts with EWS, whose cellular localization depends upon its RGG motifs targeted for methylation...
  2. Lim S, Jeong Y, Kim D, Park M, Choi J, Kim S, et al. Activation of PRMT1 and PRMT5 mediates hypoxia- and ischemia-induced apoptosis in human lung epithelial cells and the lung of miniature pigs: the role of p38 and JNK mitogen-activated protein kinases. Biochem Biophys Res Commun. 2013;440:707-13 pubmed publisher
    ..In A459 cells, hypoxia increased the expression of PRMT1 and PRMT5, and overexpression of PRMT1 and PRMT5 induced apoptosis...
  3. Fronz K, Otto S, Kölbel K, Kuhn U, Friedrich H, Schierhorn A, et al. Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J Biol Chem. 2008;283:20408-20 pubmed publisher
    ..Recombinant PRMT1, -3, and -6 also methylated PABPN1...
  4. An W, Kim J, Roeder R. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell. 2004;117:735-48 pubmed
    ..templates and (co)activators to demonstrate (1) the additional involvement of protein arginine methyltransferases PRMT1 and CARM1 in p53 function; (2) both independent and ordered cooperative functions of p300, PRMT1, and CARM1; and (..
  5. Robin Lespinasse Y, Sentis S, Kolytcheff C, Rostan M, Corbo L, Le Romancer M. hCAF1, a new regulator of PRMT1-dependent arginine methylation. J Cell Sci. 2007;120:638-47 pubmed
    ..Although protein arginine methyltransferase 1 (PRMT1) is the major arginine methyltransferase in mammals, little is known about the regulation of its activity, except ..
  6. Goulet I, Gauvin G, Boisvenue S, Cote J. Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization. J Biol Chem. 2007;282:33009-21 pubmed
    b>PRMT1 is the predominant member of a family of protein arginine methyltransferases (PRMTs) that have been implicated in various cellular processes, including transcription, RNA processing, and signal transduction...
  7. Boisvert F, Rhie A, Richard S, Doherty A. The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. Cell Cycle. 2005;4:1834-41 pubmed
    ..Herein, we show that the GAR motif of 53BP1 is arginine methylated by protein arginine methyltransferase 1 (PRMT1), the same methyltransferase that methylates MRE11...
  8. Nicholson T, Chen T, Richard S. The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation. Pharmacol Res. 2009;60:466-74 pubmed publisher
    ..Herein, we discuss these recent advances, focusing on the role of PRMT1, the major asymmetric arginine methyltransferase, in cellular processes and its link to human diseases.
  9. Mathioudaki K, Papadokostopoulou A, Scorilas A, Xynopoulos D, Agnanti N, Talieri M. The PRMT1 gene expression pattern in colon cancer. Br J Cancer. 2008;99:2094-9 pubmed publisher
    ..This is a first attempt to acquire an insight on the possible relation of the expression pattern of protein arginine methyltransferase 1 and colon cancer progression. ..

More Information


  1. Du K, Arai S, Kawamura T, Matsushita A, Kurokawa R. TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation. Biochem Biophys Res Commun. 2011;404:991-6 pubmed publisher
    ..In the process of investigating TLS-binding proteins, we found that PRMT1 (protein arginine methyltransferase 1) was in complex with TLS...
  2. Butler J, Zurita Lopez C, Clarke S, Bedford M, Dent S. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem. 2011;286:12234-44 pubmed publisher
    ..These findings are the first to demonstrate that post-translational modifications occur on the Ash2L protein and provide a novel example of cross-talk between chromatin-modifying enzyme complexes. ..
  3. Chang Y, Hua W, Yao C, Hwang S, Hung Y, Kuan C, et al. Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. J Biol Chem. 2010;285:20595-606 pubmed publisher
    Protein-arginine methyltransferase 1 (PRMT1) plays pivotal roles in various cellular processes. However, its role in megakaryocytic differentiation has yet to be investigated...
  4. Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford M, et al. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007;27:120-34 pubmed
    ..Collectively, our data highlight coactivator methylation as an important regulatory mechanism in hormonal signaling. ..
  5. Wada K, Inoue K, Hagiwara M. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Biochim Biophys Acta. 2002;1591:1-10 pubmed
    ..Here we report that several proteins extracted from HeLa cells were methylated by PRMT1 (protein arginine N-methyltransferease 1) even on a nitrocellulose membrane, while proteins from Escherichia coli ..
  6. Tradewell M, Yu Z, Tibshirani M, Boulanger M, Durham H, Richard S. Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations. Hum Mol Genet. 2012;21:136-49 pubmed publisher
    ..Depletion of protein arginine methyltransferase 1 (PRMT1; the enzyme that methylates FUS) in mouse embryonic fibroblasts by gene knockout, or in human HEK293 cells by ..
  7. Lin W, Gary J, Yang M, Clarke S, Herschman H. The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem. 1996;271:15034-44 pubmed
    ..We term the protein- arginine N-methyltransferase (EC gene "PRMT1, " for protein-arginine methyltransferase 1...
  8. Wang H, Huang Z, Xia L, Feng Q, Erdjument Bromage H, Strahl B, et al. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science. 2001;293:853-7 pubmed
    ..purification, molecular identification, and functional characterization of a histone H4-specific methyltransferase PRMT1, a protein arginine methyltransferase. PRMT1 specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo...
  9. Mowen K, Tang J, Zhu W, Schurter B, Shuai K, Herschman H, et al. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell. 2001;104:731-41 pubmed
    ..Here we demonstrate arginine methylation of STAT1 by the protein arginine methyl-transferase PRMT1 as a novel requirement for IFNalpha/beta-induced transcription...
  10. Cote J, Boisvert F, Boulanger M, Bedford M, Richard S. Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell. 2003;14:274-87 pubmed
    ..RNA binding protein, associates with and is methylated in vivo by the protein arginine N-methyltransferase 1 (PRMT1)...
  11. Rezai Zadeh N, Zhang X, Namour F, Fejer G, Wen Y, Yao Y, et al. Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. Genes Dev. 2003;17:1019-29 pubmed
    ..transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter...
  12. Zhang X, Zhou L, Cheng X. Crystal structure of the conserved core of protein arginine methyltransferase PRMT3. EMBO J. 2000;19:3509-19 pubmed
    ..In addition, crystal packing and solution behavior suggest dimer formation of the PRMT3 core. ..
  13. Lakowski T, Frankel A. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Biochem J. 2009;421:253-61 pubmed publisher
    ..Here we report methylation activity from PRMT2 and compare it with PRMT1 activity using UPLC-MS/MS (ultra-performance liquid chromatography-tandem MS), gel electrophoresis, and thin-layer ..
  14. Yamaguchi A, Kitajo K. The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLS. PLoS ONE. 2012;7:e49267 pubmed publisher
    ..for FUS/TLS, we performed a yeast two-hybrid screening and found that protein arginine methyltransferase 1 (PRMT1) is one of binding partners primarily in the nucleus...
  15. Jobert L, Argentini M, Tora L. PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. Exp Cell Res. 2009;315:1273-86 pubmed publisher
    ..Furthermore, we identify protein arginine N-methyltransferase 1 (PRMT1) as a TAF15 interactor and the major PRMT responsible for its methylation...
  16. Herrmann F, Fackelmayer F. Nucleo-cytoplasmic shuttling of protein arginine methyltransferase 1 (PRMT1) requires enzymatic activity. Genes Cells. 2009;14:309-17 pubmed publisher
    ..modification of proteins catalyzed by a family of protein arginine methyltransferases (PRMT), of which PRMT1 is the predominant member in human cells...
  17. Boisvert F, Déry U, Masson J, Richard S. Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev. 2005;19:671-6 pubmed
    ..Herein we show that the MRE11 checkpoint protein is arginine methylated by PRMT1. Mutation of the arginines within MRE11 severely impaired the exonuclease activity of MRE11 but did not influence ..
  18. Sakamaki J, Daitoku H, Ueno K, Hagiwara A, Yamagata K, Fukamizu A. Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. Proc Natl Acad Sci U S A. 2011;108:6085-90 pubmed publisher
    ..We have previously reported that PRMT1 methylates Forkhead box O transcription factors at two arginine residues within an Akt consensus phosphorylation ..
  19. Shia W, Okumura A, Yan M, Sarkeshik A, Lo M, Matsuura S, et al. PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential. Blood. 2012;119:4953-62 pubmed publisher
    ..Here, we report the discovery of a novel AE9a binding partner PRMT1 (protein arginine methyltransferase 1)...
  20. Baldwin G, Carnegie P. Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin. Science. 1971;171:579-81 pubmed
    ..Methylation may aid in the transfer of this region of the protein into the nonpolar environment within myelin and in maintaining the integrity of myelin. ..
  21. Barrero M, Malik S. Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Mol Cell. 2006;24:233-43 pubmed
    ..Here, we have identified the arginine methyltransferase PRMT1 as a coactivator for HNF4, an orphan nuclear receptor that regulates the expression of genes involved in diverse ..
  22. Le Romancer M, Treilleux I, Leconte N, Robin Lespinasse Y, Sentis S, Bouchekioua Bouzaghou K, et al. Regulation of estrogen rapid signaling through arginine methylation by PRMT1. Mol Cell. 2008;31:212-21 pubmed publisher
    ..Here we report a paradigm of ERalpha regulation through arginine methylation by PRMT1, which transiently methylates arginine 260 within the ERalpha DNA-binding domain...
  23. Mostaqul Huq M, Gupta P, Tsai N, White R, Parker M, Wei L. Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation. EMBO J. 2006;25:5094-104 pubmed
    ..The biological activity of RIP140 was suppressed by protein arginine methyltransferase 1 (PRMT1) due to RIP140 methylation, which reduced the recruitment of histone deacetylases to RIP140 and facilitated its ..
  24. Zhang X, Cheng X. Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure. 2003;11:509-20 pubmed
    b>PRMT1 is the predominant type I protein arginine methyltransferase in mammals and highly conserved among all eukaryotes. It is essential for early postimplantation development in mouse...
  25. Cheung N, Chan L, Thompson A, Cleary M, So C. Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol. 2007;9:1208-15 pubmed
    ..Although the methylation of arginine 3 of histone 4 (H4R3) by protein arginine methyltransferase 1 (PRMT1) is a critical modification for active chromatin and prevention of heterochromatin spread, there has been no ..
  26. Berthet C, Guéhenneux F, Revol V, Samarut C, Lukaszewicz A, Dehay C, et al. Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects. Genes Cells. 2002;7:29-39 pubmed
    ..BTG1 and 2 have been shown to interact with PRMT1 (predominant cellular arginine N-methyltransferase of type I)...
  27. Lee J, Bedford M. PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep. 2002;3:268-73 pubmed
    The arginine methyltransferases CARM1 and PRMT1 associate with the p160 family of nuclear hormone receptor coactivators. This association enhances transcriptional activation by nuclear receptors...
  28. Scott H, Antonarakis S, Lalioti M, Rossier C, Silver P, Henry M. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). Genomics. 1998;48:330-40 pubmed
    ..the identification and characterization of two putative human arginine methyltransferases termed HRMT1L1 and HRMT1L2. In addition to methyltransferase similarities, the N-terminal region of the HRMT1L1 protein contains an Src ..
  29. POPE A, Karuppiah K, Cardounel A. Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production. Pharmacol Res. 2009;60:461-5 pubmed publisher
  30. Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field H, et al. Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer. 2011;128:562-73 pubmed publisher
    ..examined expression levels of genes belonging to the PRMT family and found significantly higher expression of PRMT1 and PRMT6, both of which are Type I PRMTs, in cancer cells of various tissues than in non-neoplastic cells...
  31. Chang Y, Hsu S, Chau G, Huang C, Sung J, Hua W, et al. Identification of the methylation preference region in heterogeneous nuclear ribonucleoprotein K by protein arginine methyltransferase 1 and its implication in regulating nuclear/cytoplasmic distribution. Biochem Biophys Res Commun. 2011;404:865-9 pubmed publisher
    ..of hnRNP K as substrates, here we show by direct methylation assay that protein arginine methyltransferase 1 (PRMT1) methylated preferentially in a.a. 280-307 of the RGG motif. Kinetic analysis revealed that deletion of a.a...
  32. Rajpurohit R, Lee S, Park J, Paik W, Kim S. Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase. J Biol Chem. 1994;269:1075-82 pubmed
  33. Zhao X, Jankovic V, Gural A, Huang G, Pardanani A, Menendez S, et al. Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev. 2008;22:640-53 pubmed publisher
    ..We show that RUNX1 is arginine-methylated in vivo by the arginine methyltransferase PRMT1, and that PRMT1 serves as a transcriptional coactivator for RUNX1 function...
  34. Tang J, Kao P, Herschman H. Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. J Biol Chem. 2000;275:19866-76 pubmed
    ..Protein-arginine methyltransferase I (PRMT1) contributes >90% of type I protein-arginine methyltransferase activity in cells and tissues...
  35. Nichols R, Wang X, Tang J, Hamilton B, High F, Herschman H, et al. The RGG domain in hnRNP A2 affects subcellular localization. Exp Cell Res. 2000;256:522-32 pubmed
    ..with [(3)H]AdoMet of GST-tagged hnRNP A2 RGG mutants, using recombinant protein arginine methyltransferase (PRMT1), shows (i) that hnRNP A2 is a substrate for PRMT1 and (ii) that methylated residues are found only in the RGG ..
  36. Abramovich C, Yakobson B, Chebath J, Revel M. A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 1997;16:260-6 pubmed
    ..Several positive clones representing a protein sequence designated IR1B4 were recovered from a human cDNA library...
  37. Strahl B, Briggs S, Brame C, Caldwell J, Koh S, Ma H, et al. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr Biol. 2001;11:996-1000 pubmed
    ..Recent discoveries of protein arginine methyltransferases, CARM1 and PRMT1, as transcriptional coactivators for nuclear receptors suggest that histones may be physiological targets of these ..
  38. Kwak Y, Guo J, Prajapati S, Park K, Surabhi R, Miller B, et al. Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties. Mol Cell. 2003;11:1055-66 pubmed
    ..approach to demonstrate that SPT5 was specifically associated with the protein arginine methyltransferases PRMT1 and PRMT5 and that SPT5 methylation regulated its interaction with RNA polymerase II...
  39. Herrmann F, Lee J, Bedford M, Fackelmayer F. Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo. J Biol Chem. 2005;280:38005-10 pubmed
    ..catalyzed by a family of protein arginine methyltransferases (PRMT), the predominant member of which is PRMT1. Despite its major role in arginine methylation of nuclear proteins, surprisingly little is known about the ..
  40. Wagner S, Weber S, Kleinschmidt M, Nagata K, Bauer U. SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. J Biol Chem. 2006;281:27242-50 pubmed
    ..Occurrence of histone H4 arginine (Arg) 3 methylation by protein arginine methyltransferase 1 (PRMT1) represents an early promoter event in ER (estrogen receptor)-regulated gene activation...
  41. Lee J, Sayegh J, Daniel J, Clarke S, Bedford M. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem. 2005;280:32890-6 pubmed
    ..This novel enzyme is most closely related to PRMT1, although it has a distinctive N-terminal region...
  42. Blackwell E, Zhang X, Ceman S. Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA. Hum Mol Genet. 2010;19:1314-23 pubmed publisher
    ..In addition, we found that PRMT1 co-immunoprecipitated with FMRP isolated from cells and that siRNAs directed against PRMT1 led to reduced FMRP ..
  43. Herrmann F, Bossert M, Schwander A, Akgün E, Fackelmayer F. Arginine methylation of scaffold attachment factor A by heterogeneous nuclear ribonucleoprotein particle-associated PRMT1. J Biol Chem. 2004;279:48774-9 pubmed
    ..We show here that the predominant arginine methyltransferase in human cells, protein arginine methyltransferase 1 (PRMT1), is associated with hnRNP complexes, dependent on the methylation status of the cell, and that it methylates its ..
  44. Wang Y, Wysocka J, Sayegh J, Lee Y, Perlin J, Leonelli L, et al. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004;306:279-83 pubmed
    ..multiple sites in histones H3 and H4, including those sites methylated by coactivators CARM1 (H3 Arg17) and PRMT1 (H4 Arg3)...
  45. Wooderchak W, Zang T, Zhou Z, Acuña M, Tahara S, Hevel J. Substrate profiling of PRMT1 reveals amino acid sequences that extend beyond the "RGG" paradigm. Biochemistry. 2008;47:9456-66 pubmed publisher
    Protein arginine methyltransferase 1 (PRMT1) catalyzes the mono- and dimethylation of certain protein arginine residues...
  46. Cha B, Kim W, Kim Y, Hwang B, Park S, Yoon J, et al. Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Oncogene. 2011;30:2379-89 pubmed publisher
    ..Here, we provide evidence that protein arginine methyltransferase 1 (PRMT1) directly interacts with and methylates the 378th arginine residue of Axin both in vitro and in vivo...
  47. Ostareck Lederer A, Ostareck D, Rucknagel K, Schierhorn A, Moritz B, Huttelmaier S, et al. Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src. J Biol Chem. 2006;281:11115-25 pubmed
    ..This led to an inhibition of c-Src activation and hnRNP K phosphorylation. These findings support the role of arginine methylation in the regulation of protein-protein interactions. ..
  48. Scorilas A, Black M, Talieri M, Diamandis E. Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene. Biochem Biophys Res Commun. 2000;278:349-59 pubmed
    ..The cDNA for human PRMT1 (HRMT1L2) was recently identified...
  49. Hassa P, Covic M, Bedford M, Hottiger M. Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol. 2008;377:668-78 pubmed publisher
    ..Here, we show that protein arginine methyltransferase 1 (PRMT1) synergistically coactivates NF-kappaB-dependent gene expression at the macrophage inflammatory protein 2 and ..
  50. Cho J, Lee M, Yoon K, Lee J, Cho S, Choi E. Arginine methylation-dependent regulation of ASK1 signaling by PRMT1. Cell Death Differ. 2012;19:859-70 pubmed publisher
    ..We now show that PRMT1 methylates apoptosis signal-regulating kinase 1 (ASK1) at arginine residues 78 and 80 and thereby negatively ..
  51. Bedford M, Frankel A, Yaffe M, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. J Biol Chem. 2000;275:16030-6 pubmed
    ..These results suggest that protein arginine methylation can selectively modulate certain protein-protein interactions and that mechanisms exist for the irreversible regulation of SH3 domain-mediated interactions. ..
  52. Ferrigno A, Di Pasqua L, Berardo C, Siciliano V, Rizzo V, Adorini L, et al. The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury. PLoS ONE. 2018;13:e0191430 pubmed publisher
    ..Conversely, the mechanism involved in further increasing biliary ADMA levels in sham and I/R groups treated with OCA appears to be MATE-1-dependent. ..
  53. Pak M, Lakowski T, Thomas D, Vhuiyan M, Hüsecken K, Frankel A. A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity. Biochemistry. 2011;50:8226-40 pubmed publisher
    ..b>PRMT1 is responsible for most cellular arginine methylation activity and can work independently or in collaboration with ..
  54. Lu R, Wang G. Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia. Front Oncol. 2017;7:241 pubmed publisher
    ..of "epigenetic writers" (such as histone methyltransferases MLL/KMT2A, G9A/KMT1C, EZH2/KMT6A, DOT1L/KMT4, and PRMT1), "epigenetic readers" (such as BRD4 and plant homeodomain finger proteins), and "epigenetic erasers" (such as ..
  55. Kzhyshkowska J, Schutt H, Liss M, Kremmer E, Stauber R, Wolf H, et al. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. Biochem J. 2001;358:305-14 pubmed
    ..The predominant mammalian arginine methyltransferase HRMT1L2 (hPRMT1) did not detectably methylate endogenous E1B-AP5 despite efficiently methylating a recombinant RGG-box ..