PRKG1

Summary

Gene Symbol: PRKG1
Description: protein kinase cGMP-dependent 1
Alias: AAT8, PKG, PKG1, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, cGMP-dependent protein kinase 1, protein kinase, cGMP-dependent, regulatory, type I, beta, protein kinase, cGMP-dependent, type I
Species: human
Products:     PRKG1

Top Publications

  1. Richie Jannetta R, Busch J, Higgins K, Corbin J, Francis S. Isolated regulatory domains of cGMP-dependent protein kinase Ialpha and Ibeta retain dimerization and native cGMP-binding properties and undergo isoform-specific conformational changes. J Biol Chem. 2006;281:6977-84 pubmed
    Molecular mechanisms that provide for cGMP activation of cGMP-dependent protein kinase (PKG) are unknown. PKGs are dimeric; each monomer contains a regulatory (R) and catalytic (C) domain...
  2. Yuasa K, Omori K, Yanaka N. Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. J Biol Chem. 2000;275:4897-905 pubmed
    cGMP-dependent protein kinase (cGK) is a major cellular receptor of cGMP and plays important roles in cGMP-dependent signal transduction pathways...
  3. Casteel D, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, et al. cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I. J Biol Chem. 2002;277:32003-14 pubmed
    ..Binding of G-kinase to TFII-I may position the kinase to phosphorylate and regulate TFII-I and/or factors that interact with TFII-I at the serum-response element. ..
  4. Richie Jannetta R, Francis S, Corbin J. Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function. J Biol Chem. 2003;278:50070-9 pubmed
    ..In PKG Ibeta this includes eight Leu/Ile heptad repeats, and in the present study, deletion and site-directed mutagenesis ..
  5. Casteel D, Boss G, Pilz R. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. J Biol Chem. 2005;280:38211-8 pubmed
    ..Two splice variants of type I cGMP-dependent protein kinase (PKG Ialpha and Ibeta) differ only in their N-terminal approximately 100 amino acids, which mediate binding to different ..
  6. Alhawaj R, Patel D, Kelly M, Sun D, Wolin M. Heme biosynthesis modulation via δ-aminolevulinic acid administration attenuates chronic hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015;308:L719-28 pubmed publisher
    ..Because ALA increases BPA protoporphyrin IX (a stimulator of guanylate cyclase) and cGMP-mediated protein kinase G (PKG) activity, the effects of the PKG activator 8-bromo-cGMP were examined and found to also attenuate the ET-1-induced ..
  7. Malykhina A, Lei Q, Chang S, Pan X, Villamor A, Smith A, et al. Bladder outlet obstruction triggers neural plasticity in sensory pathways and contributes to impaired sensitivity in erectile dysfunction. Am J Physiol Regul Integr Comp Physiol. 2013;304:R837-45 pubmed publisher
    ..A significant decrease in neuronal NOS expression, but not in endothelial NOS or protein kinase G (PKG-1), was detected in the CCSM of the obstructed animals...
  8. Zhang C, Zhang B, Deng W, Duan M, Chen W, Wu Z. Role of estrogen receptor ? selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis. World J Gastroenterol. 2016;22:4484-500 pubmed publisher
    ..endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS, and promoted the activities of protein kinase G (PKG), which is an NO effector in the liver...
  9. Chen S, Osaki N, Shimotoyodome A. Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes. Biochem Biophys Res Commun. 2015;461:1-7 pubmed publisher
    ..The cells were treated with inhibitors of protein kinase A (PKA), protein kinase C (PKC), protein kinase G (PKG), or mitogen-activated protein kinase (MAPK) to determine the responsible pathway...

More Information

Publications145 found, 100 shown here

  1. Diaz Lucena D, Gutierrez Mecinas M, Moreno B, Martínez Sánchez J, Pifarre P, Garcia A. Mechanisms Involved in the Remyelinating Effect of Sildenafil. J Neuroimmune Pharmacol. 2018;13:6-23 pubmed publisher
    ..sildenafil stimulates remyelination by direct effects on CNS cells in a nitric oxide (NO)-cGMP-protein kinase G (PKG)-dependent manner...
  2. Chettimada S, Joshi S, Dhagia V, Aiezza A, Lincoln T, Gupte R, et al. Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency. Am J Physiol Heart Circ Physiol. 2016;311:H904-H912 pubmed publisher
    ..Therefore, our results suggest that the expression of VSMC contractile proteins induced by G6PD inhibition occurs via PKG1α-dependent and -independent pathways.
  3. Deng Q, Sheng W, Zhang G, Weng S, Yang X, Zhong Y. Signalling mechanism for somatostatin receptor 5-mediated suppression of AMPA responses in rat retinal ganglion cells. Neuropharmacology. 2016;107:215-226 pubmed publisher
    ..SRIF persisted to suppress the AMPA currents when cGMP-protein kinase G (PKG) and phosphatidylinositol (PI)-/phosphatidylcholine (PC)-phospholipase C (PLC) signalling pathways were blocked...
  4. Ellis D. Guanylate cyclase activators, cell volume changes and IOP reduction. Cell Physiol Biochem. 2011;28:1145-54 pubmed publisher
    ..BAY-58-2667); activation of either results in formation of cyclic GMP (cGMP) and activation of protein kinase G (PKG) and subsequent phosphorylation of target proteins, including the high conductance calcium activated potassium ..
  5. Nagasu H, Satoh M, Kidokoro K, Nishi Y, Channon K, Sasaki T, et al. Endothelial dysfunction promotes the transition from compensatory renal hypertrophy to kidney injury after unilateral nephrectomy in mice. Am J Physiol Renal Physiol. 2012;302:F1402-8 pubmed publisher
    ..hypothesized that the endothelial nitric oxide synthase (eNOS) [soluble guanylate cyclase (sGC)] protein kinase G (PKG) pathway plays an important role in compensatory renal hypertrophy after unilateral nephrectomy...
  6. Lee M, Sulistyowati E, Hsu J, Huang B, Dai Z, Wu B, et al. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways. Molecules. 2019;24: pubmed publisher
    ..has focused on the activation of nitric oxide (NO)-guanosine 3', 5'cyclic monophosphate (cGMP)-protein kinase G (PKG) signaling pathway triggered by mitogen-activated protein kinase (MAPK) family, including extracellular-signal ..
  7. Zheng Y, Yin X, Huo F, Xiong H, Mei Z. Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury. J Ethnopharmacol. 2015;173:204-11 pubmed publisher
    ..200, 400, 800mg/kg) also inhibited the protein expression of NMDAR, PKCγ and the mRNA expression of iNOS and PKGΙ in the spinal cord...
  8. Staurengo Ferrari L, Mizokami S, Fattori V, Silva J, Zanichelli P, Georgetti S, et al. The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Naunyn Schmiedebergs Arch Pharmacol. 2014;387:1053-68 pubmed publisher
  9. Liu F, Weng S, Yang X, Zhong Y. Orexin-A potentiates L-type calcium/barium currents in rat retinal ganglion cells. Neuroscience. 2015;305:225-37 pubmed publisher
    ..monophosphate (cAMP)-protein kinase A (PKA) nor guanosine 3',5'-cyclic monophosphate (cGMP)-protein kinase G (PKG) signaling pathway was likely involved, as orexin-A persisted to potentiate the IBa,L of GCs no matter these two ..
  10. Lozano Cuenca J, Gonzalez Hernandez A, López Canales O, Villagrana Zesati J, Rodríguez Choreão J, Morín Zaragoza R, et al. Possible mechanisms involved in the vasorelaxant effect produced by clobenzorex in aortic segments of rats. Braz J Med Biol Res. 2017;50:e5765 pubmed publisher
    ..These results suggest that the direct vasorelaxant effect by clobenzorex on phenylephrine-precontracted rat aortic rings involved stimulation of the NO/cGMP/PKG/Ca2+-activated K+ channel pathway.
  11. Carvalho T, Mizokami S, Ferraz C, Manchope M, Borghi S, Fattori V, et al. The granulopoietic cytokine granulocyte colony-stimulating factor (G-CSF) induces pain: analgesia by rutin. Inflammopharmacology. 2019;: pubmed publisher
    ..The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG)-ATP-sensitive potassium channel (KATP) signaling pathway activation is one of the analgesic mechanisms ..
  12. Sopko N, Matsui H, Hannan J, Berkowitz D, Champion H, Hsu L, et al. Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation. J Sex Med. 2015;12:1878-85 pubmed publisher
    ..ICP and frequency of erections were assessed. Penile tissues were analyzed for NOS, protein kinase G (PKG), PDE5, and ROS activities. BM-SS mice demonstrated a priapism phenotype...
  13. Longhi Balbinot D, Rossaneis A, Pinho Ribeiro F, Bertozzi M, Cunha F, Alves Filho J, et al. The nitroxyl donor, Angeli's salt, reduces chronic constriction injury-induced neuropathic pain. Chem Biol Interact. 2016;256:1-8 pubmed publisher
    ..ODQ, a soluble guanylate cyclase inhibitor), KT5823 (an inhibitor of protein kinase G [PKG]) or glibenclamide (GLB, an ATP-sensitive potassium channel blocker)...
  14. Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss G, Cory E, et al. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017;32:46-59 pubmed publisher
    ..The positive NO effects in osteoblasts were mediated by cGMP/protein kinase G (PKG), but some of the osteoclast-inhibitory effects appeared to be cGMP-independent...
  15. VerPlank J, Goldberg A. Regulating protein breakdown through proteasome phosphorylation. Biochem J. 2017;474:3355-3371 pubmed publisher
    ..Inhibitors of phosphodiesterases by activating PKA or PKG (protein kinase G) can stimulate proteasomal degradation of misfolded proteins that cause neurodegenerative or ..
  16. Das A, Durrant D, Salloum F, Xi L, Kukreja R. PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer. Pharmacol Ther. 2015;147:12-21 pubmed publisher
    ..heart against I/R injury through increased expression of nitric oxide synthases, activation of protein kinase G (PKG), PKG-dependent hydrogen sulfide generation, and phosphorylation of glycogen synthase kinase-3β - a master ..
  17. Liu C, Yeh J, Liou S, Wu B, Chen I. Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization. Kaohsiung J Med Sci. 2016;32:55-67 pubmed publisher
    ..In H9c2 cells, Y-27632 (50μM) and PKG antagonist KT5823 [2,3,9,10,11,12-hexahydro-10R- methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo(1,2,3-fg:3',2',..
  18. Zhang A, Zhao L, Li N, Duan H, Liu H, Pu F, et al. Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the Cyclic GMP/Protein Kinase G and NF-κB Signaling Pathway. J Virol. 2017;91: pubmed publisher
    ..Furthermore, CO was found to suppress PRRSV replication via the activation of the cyclic GMP/protein kinase G (cGMP/PKG) signaling pathway...
  19. Lee M, Tsai K, Hsu J, Shin S, Wu J, Yeh J. Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways. Sci Rep. 2016;6:31788 pubmed publisher
    ..monophosphate (cGMP) levels, protein expressions of eNOS, soluble guanylyl cyclase (sGC?), protein kinase G (PKG) and Rho kinase (ROCK) II pathway were measured in both in vivo and in vitro...
  20. Thoonen R, Giovanni S, Govindan S, Lee D, Wang G, Calamaras T, et al. Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate. Circ Heart Fail. 2015;8:1115-22 pubmed publisher
    ..However, PKG-activating drugs have been limited by hypotension arising from PKG-induced vasodilation...
  21. Holland N, Francisco J, Johnson S, Morgan J, Dennis T, Gadireddy N, et al. Cyclic Nucleotide-Directed Protein Kinases in Cardiovascular Inflammation and Growth. J Cardiovasc Dev Dis. 2018;5: pubmed publisher
    ..CVD with particular emphasis on cyclic AMP-dependent protein kinase (PKA) and cyclic GMP-dependent protein kinase (PKG)...
  22. Wu Y, Zhang M, Liu R, Zhao C. Oxidative Stress-Activated NHE1 Is Involved in High Glucose-Induced Apoptosis in Renal Tubular Epithelial Cells. Yonsei Med J. 2016;57:1252-9 pubmed publisher
    ..We also found that activated cyclic GMP-Dependent Protein Kinase Type I (PKG) signaling promoted the production of ROS, which contributed to the regulation of NHE1 functions...
  23. Seo M, Li H, An J, Jang J, Jung H, Kim T, et al. The vasodilatory effect of the antidiabetic drug linagliptin via inhibition of Rho-associated protein kinase in aortic smooth muscle. Life Sci. 2019;219:1-10 pubmed publisher
    ..inhibitor SQ22536, protein kinase A (PKA) inhibitor KT5720, guanylyl cyclase inhibitor ODQ, or protein kinase G (PKG) inhibitor KT5823 did not alter the vasodilatory effect of linagliptin...
  24. Gim H, Nam J, Lee S, Shim J, Kim H, Ha K, et al. Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine. Cell Physiol Biochem. 2015;35:2422-36 pubmed publisher
    ..ODQ), an inhibitor of guanylate cyclase, and of RP-8-CPT-cGMPS, an inhibitor of protein kinase G (PKG). These inhibitors blocked the inhibitory effects of quercetin on pacemaker activities...
  25. Coura C, Chaves H, do Val D, Vieira L, Silveira F, Dos Santos Lopes F, et al. Mechanisms involved in antinociception induced by a polysulfated fraction from seaweed Gracilaria cornea in the temporomandibular joint of rats. Int J Biol Macromol. 2017;97:76-84 pubmed publisher
    ..effect depends on the nitric oxide/cyclic GMP/protein kinase G/ATP-sensitive potassium channel (NO/cGMP/PKG/K+ATP) pathway because it was prevented by pretreatment with inhibitors of nitric oxide ..
  26. Lee J, Linge H, Ochani K, Lin K, Miller E. Regulation of angiopoietin-2 secretion from human pulmonary microvascular endothelial cells. Exp Lung Res. 2016;42:335-345 pubmed
    ..kinase A (PKA)-Ca2+ and nitric oxide (NO)-3'5'-cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG)-Ca2+ pathways and partially regulated by N-ethyl-maleimide-sensitive factor-Ca2+ pathways...
  27. García Pardo M, Roger Sánchez C, Rodriguez Arias M, Minarro J, Aguilar M. Pharmacological modulation of protein kinases as a new approach to treat addiction to cocaine and opiates. Eur J Pharmacol. 2016;781:10-24 pubmed publisher
    ..kinase C (PKC) family (including PKM?), cAMP-dependent protein kinase A (PKA), cGMP-dependent protein kinase G (PKG), the phosphatidylinositol 3-kinase (PI3K) pathway and its downstream target mammalian target of Rapamycin (mTOR), ..
  28. Rogacka D, Audzeyenka I, Rachubik P, Rychłowski M, Kasztan M, Jankowski M, et al. Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGIα signaling pathways. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1312-1325 pubmed publisher
    ..of the actin cytoskeleton and attenuated oxidative activation of PKGIα and changes in the phosphorylation of PKG target proteins MYPT1 and MLC...
  29. Uckert S, Oelke M, Albrecht K, Breitmeier D, Kuczyk M, Hedlund P. Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5). Int J Impot Res. 2011;23:206-12 pubmed publisher
    ..of the cyclic GMP pathway, such as the endothelial NOS, PDE2, PDE11 and cyclic GMP-dependent protein kinase type I (cGKI) in relation to the PDE5...
  30. Li L, Li L, Chen C, Yang J, Li J, Hu N, et al. Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα. PLoS ONE. 2015;10:e0139570 pubmed publisher
    ..The involvement of PKG-Iα was further studied using cultured endothelial cells subjected to hypoxia reoxygenation (HR) injury in vitro...
  31. Manivasagam S, Vellaichamy E. Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in vitro. Biochem Biophys Res Commun. 2017;491:250-256 pubmed publisher
    ..The mRNA and protein expression profile of NPR-A, NPR-B, PKG-I and cGMP were analyzed by qPCR, Western blotting, ELISA, and immunofluorescence methods, respectively...
  32. Xia C, Bao Z, Yue C, Sanborn B, Liu M. Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases. J Biol Chem. 2001;276:19770-7 pubmed
    ..study, we shown that G-protein-activated PLC enzymes are the potential targets of cGMP-dependent protein kinases (PKG)...
  33. Lee E, Hayes D, Langsetmo K, Sundberg E, Tao T. Interactions between the leucine-zipper motif of cGMP-dependent protein kinase and the C-terminal region of the targeting subunit of myosin light chain phosphatase. J Mol Biol. 2007;373:1198-212 pubmed
    ..Nitric oxide induces vasodilation by elevating the production of cGMP, an activator of cGMP-dependent protein kinase (PKG). PKG subsequently causes smooth muscle relaxation in part via activation of myosin light chain phosphatase (MLCP)...
  34. Tinsley H, Gary B, Keeton A, Zhang W, Abadi A, Reynolds R, et al. Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Mol Cancer Ther. 2009;8:3331-40 pubmed publisher
    ..These data suggest that PDE5 inhibition is responsible for the breast tumor cell growth-inhibitory and apoptosis-inducing activity of SS and may contribute to the chemopreventive properties of sulindac. ..
  35. Kato S, Zhang R, Roberts J. Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport. Am J Physiol Lung Cell Mol Physiol. 2013;305:L130-40 pubmed publisher
    ..These data indicate for the first time that PCs have a role in regulating PKGI proteolysis and the nuclear localization of its active cleavage product, which are important for cGMP-mediated SMC phenotype. ..
  36. Johlfs M, Gorjala P, Urasaki Y, Le T, Fiscus R. Capillary Isoelectric Focusing Immunoassay for Fat Cell Differentiation Proteomics. PLoS ONE. 2015;10:e0132105 pubmed publisher
    ..simultaneously profile three protein kinases during fat cell differentiation: cGMP-dependent protein kinase type I (PKG-I) of the nitric oxide (NO) signaling pathway, protein kinase B (Akt) of the insulin signaling pathway, and ..
  37. Li L, Lai E, Wellstein A, Welch W, Wilcox C. Differential effects of superoxide and hydrogen peroxide on myogenic signaling, membrane potential, and contractions of mouse renal afferent arterioles. Am J Physiol Renal Physiol. 2016;310:F1197-205 pubmed publisher
    ..19 ± 2%, P < 0.005) and signaled via PKG. O2 (·-) activated Ca(2+)-activated Cl(-) channels that reduced Em, whereas H2O2 activated Ca(2+)-activated and ..
  38. Chen W, Oberwinkler H, Werner F, Gaßner B, Nakagawa H, Feil R, et al. Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels. Arterioscler Thromb Vasc Biol. 2013;33:2121-9 pubmed publisher
    ..the molecular mechanisms underlying this interaction, especially the role of cGMP-dependent protein kinase I (cGKI)...
  39. Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F, Schlossmann J. Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration. FEBS J. 2015;282:3786-98 pubmed publisher
    ..cGMP-dependent protein kinase I (cGKI; PKGI) is a cGMP target protein that phosphorylates different substrates after activation through cGMP...
  40. Nagy Z, Wynne K, von Kriegsheim A, Gambaryan S, Smolenski A. Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets. J Biol Chem. 2015;290:29974-83 pubmed publisher
    ..PGI2 and NO effects are mediated by cyclic nucleotides, cAMP- and cGMP-dependent protein kinases (PKA, PKG), and largely unknown PKA and PKG substrate proteins...
  41. Coppens S, Koralkova P, Aeby A, Mojzikova R, Deconinck N, Kadhim H, et al. Recurrent episodes of myoglobinuria, mental retardation and seizures but no hemolysis in two brothers with phosphoglycerate kinase deficiency. Neuromuscul Disord. 2016;26:207-10 pubmed publisher
    ..756 + 3A > G mutation is discussed, as well as the genotype-to-phenotype correlation with regard to previously described mutations (PGK Fukuroi and PGK Antwerp), which also result in C-terminal truncated proteins. ..
  42. Jackson N, Ceresa B. Protein Kinase G facilitates EGFR-mediated cell death in MDA-MB-468 cells. Exp Cell Res. 2016;346:224-32 pubmed publisher
    ..After identifying Cyclic GMP-dependent Protein Kinase G (PKG) as a plausible intermediate, we wanted to determine the temporal relationship of these two proteins in the ..
  43. Kono J, Konno K, Talukder A, Fuse T, Abe M, Uchida K, et al. Distribution of corticotropin-releasing factor neurons in the mouse brain: a study using corticotropin-releasing factor-modified yellow fluorescent protein knock-in mouse. Brain Struct Funct. 2017;222:1705-1732 pubmed publisher
    ..A population of CRF neurons was demonstrated to be cholinergic in the midbrain tegmentum. The CRF-Venus∆Neo mouse may be useful for studying the structural and functional properties of CRF neurons in the mouse brain. ..
  44. Gao J, Xu Y, Lei M, Shi J, Gong Q. Icariside II, a PDE5 inhibitor from Epimedium brevicornum, promotes neuron-like pheochromocytoma PC12 cell proliferation via activating NO/cGMP/PKG pathway. Neurochem Int. 2018;112:18-26 pubmed publisher
    ..were treated with ICS II alone or together with L-NMMA, H89, KT-5823, and/or LY294002 (the inhibitor of NOS, PKA, PKG, PI3K, respectively)...
  45. Leung E, Wong J, Johlfs M, Tsang B, Fiscus R. Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation. Mol Cancer Res. 2010;8:578-91 pubmed publisher
    Previously, we showed that basal activity of nitric oxide (NO)/cyclic GMP (cGMP)/protein kinase G (PKG) signaling pathway protects against spontaneous apoptosis and confers resistance to cisplatin-induced apoptosis in human ovarian ..
  46. Li R, Bourcy K, Wang T, Sun M, Kang Y. The involvement of vimentin in copper-induced regression of cardiomyocyte hypertrophy. Metallomics. 2015;7:1331-7 pubmed publisher
    ..growth factor receptor-1 (VEGFR-1) and cyclic guanosine monophosphate (cGMP)-dependent protein kinase-1 (PKG-1) is required for the regression...
  47. Tamura R, Yoshihara K, Yamawaki K, Suda K, Ishiguro T, Adachi S, et al. Novel kinase fusion transcripts found in endometrial cancer. Sci Rep. 2015;5:18657 pubmed publisher
    ..focused on three in-frame kinase fusion transcripts that retain a kinase domain (CPQ-PRKDC, CAPZA2-MET, and VGLL4-PRKG1). We detected only CPQ-PRKDC fusion transcript in three of 122 primary endometrial cancer tissues...
  48. Jiang Q, Lu W, Yang K, Hadadi C, Fu X, Chen Y, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-? signaling axis. Am J Physiol Cell Physiol. 2016;311:C136-49 pubmed publisher
    ..We have previously shown that, under hypoxic conditions, inhibition of protein kinase G (PKG) and peroxisome proliferator-activated receptor-? (PPAR-?) signaling axis results in the upregulation of TRPC (Wang ..
  49. Hill M, Braun A. Oxidant signaling underlies PKGIα modulation of Ca2+ sparks and BKCa in myogenically active arterioles. Sci Signal. 2016;9:fs15 pubmed
    ..In this issue of Science Signaling, Khavandi et al suggest a role for cyclic guanosine monophosphate (cGMP)-dependent protein kinase G Iα (PKGIα) activated by oxidants in a cGMP-independent manner. ..
  50. Guerrero Orriach J, Galán Ortega M, Ramirez Fernandez A, Ramirez Aliaga M, Moreno Cortes M, Ariza Villanueva D, et al. Cardioprotective efficacy of sevoflurane vs. propofol during induction and/or maintenance in patients undergoing coronary artery revascularization surgery without pump: A randomized trial. Int J Cardiol. 2017;243:73-80 pubmed publisher
    ..48 postoperative hours; blood and urine samples were collected at baseline and at 24h to determine Akt, ERK1/2, PKG, iNO, bradykinin receptor, caspase 3, NT proBNP and urinary NGAL...
  51. Liu L, Xu Y, Chou K. iPGK-PseAAC: Identify Lysine Phosphoglycerylation Sites in Proteins by Incorporating Four Different Tiers of Amino Acid Pairwise Coupling Information into the General PseAAC. Med Chem. 2017;13:552-559 pubmed publisher
    ..aporc.org/iPGK-PseAAC/, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved. ..
  52. Yamada T, Nishiyama M, Oba S, Jimbo H, Ikeda K, Ishii S, et al. Computational Methods for Estimating Molecular System from Membrane Potential Recordings in Nerve Growth Cone. Sci Rep. 2018;8:4559 pubmed publisher
    ..Lastly, our model predicts that chloride channel inhibition by cGMP-dependent protein kinase (PKG) is essential in the core system for regulation of the MP shifts.
  53. Butt E, Gambaryan S, Göttfert N, Galler A, Marcus K, Meyer H. Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146. J Biol Chem. 2003;278:15601-7 pubmed
    Various drugs that elevate cGMP levels and activate cGMP-dependent protein kinase (cGK) inhibit agonist-induced platelet activation...
  54. Sekine S, Ito K, Horie T. Oxidative stress and Mrp2 internalization. Free Radic Biol Med. 2006;40:2166-74 pubmed
    ..A (PKA)-selective inhibitor, a Ca(2+)-dependent conventional PKC (cPKC) inhibitor Gö6976, or a protein kinase G (PKG) inhibitor (1 microM)...
  55. Vanschouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg F, Kim C, et al. Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG). J Biol Chem. 2015;290:28631-41 pubmed publisher
    Protein kinase G (PKG) is a major receptor of cGMP and controls signaling pathways often distinct from those regulated by cAMP. Hence, the selective activation of PKG by cGMP versus cAMP is critical...
  56. Chen W, Spitzl A, Mathes D, Nikolaev V, Werner F, Weirather J, et al. Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction. Circ Res. 2016;119:237-48 pubmed publisher
    ..It was shown that NPs, via their cGMP-forming guanylyl cyclase-A (GC-A) receptor and cGMP-dependent kinase I (cGKI), strengthen systemic endothelial barrier properties in acute inflammation...
  57. Krill J, Dawson Scully K. cGMP-Dependent Protein Kinase Inhibition Extends the Upper Temperature Limit of Stimulus-Evoked Calcium Responses in Motoneuronal Boutons of Drosophila melanogaster Larvae. PLoS ONE. 2016;11:e0164114 pubmed publisher
    ..The foraging (for) gene encodes the cGMP-dependent protein kinase (PKG), has been shown to regulate thermotolerance in many stress-adapted species, including Drosophila, and could be a ..
  58. McCarty M, Dinicolantonio J. Neuroprotective potential of high-dose biotin. Med Hypotheses. 2017;109:145-149 pubmed publisher
    ..which in turn promotes an activating phosphorylation of CREB via a pathway involving cGMP and protein kinase G (PKG)...
  59. Bautista Niño P, van der Stel M, Batenburg W, de Vries R, Roks A, Danser A. Endothelium-derived hyperpolarizing factor and protein kinase G Iα activation: H2O2 versus S-nitrosothiols. Eur J Pharmacol. 2018;827:112-116 pubmed publisher
    Protein kinase G (PKG) Iα mediates the cyclic guanosine monophosphate-mediated vasodilatory effects induced by NO...
  60. Huber A, Neuhuber W, Klugbauer N, Ruth P, Allescher H. Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle. J Biol Chem. 2000;275:5504-11 pubmed
    Nitric oxide/cGMP/cGMP kinase I (cGKI) signaling causes relaxation of intestinal smooth muscle. In the gastrointestinal tract substrates of cGKI have not been identified yet...
  61. Caohuy H, Pollard H. Activation of annexin 7 by protein kinase C in vitro and in vivo. J Biol Chem. 2001;276:12813-21 pubmed
    ..These results thus lead us to hypothesize that annexin 7 may be a positive mediator for protein kinase C action in the exocytotic membrane fusion reaction in chromaffin cells. ..
  62. Ma H, Butler M, Thapa A, Belcher J, Yang F, Baehr W, et al. cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice. J Biol Chem. 2015;290:20880-92 pubmed publisher
    ..a remarkable elevation of cGMP and an increased activity of the cGMP-dependent protein kinase (protein kinase G, PKG) in CNG channel deficiency...
  63. Teich A, Sakurai M, Patel M, Holman C, Saeed F, Fiorito J, et al. PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease. J Alzheimers Dis. 2016;52:295-302 pubmed publisher
    Phosphodiesterase 5 (PDE5) is a critical component of the cGMP-PKG axis of cellular signaling in neurons, and inhibition of PDE5 has been shown to be therapeutic in a wide range of neurologic conditions in animal models...
  64. Zhang Z, Zhu J, Dong Y, Xu H, Jiang T, Li W, et al. Global transcriptome?wide analysis of the function of GDDR in acute gastric lesions. Mol Med Rep. 2017;16:8673-8684 pubmed publisher
    ..showed that the upregulated DEGs were enriched in ECM?receptor interaction and the signaling pathway of cGMP?PKG, and the downregulated DEGs were enriched in the renin?angiotensin system and glycerolipid metabolism...
  65. Orstavik S, Natarajan V, Tasken K, Jahnsen T, Sandberg M. Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1). Genomics. 1997;42:311-8 pubmed
    ..This report describes the cloning of the gene PRKG1 encoding both human type I cGK isoforms...
  66. Liu Y, Dillon A, Tillson M, Makarewich C, Nguyen V, DELL ITALIA L, et al. Volume overload induces differential spatiotemporal regulation of myocardial soluble guanylyl cyclase in eccentric hypertrophy and heart failure. J Mol Cell Cardiol. 2013;60:72-83 pubmed publisher
    ..revealed that these modifications of sGC were also reflected in caveolae-localized cGMP-dependent protein kinase (PKG) and MAPK signaling...
  67. Wang Y, Li Z, Zhang P, Poon E, Kong C, Boheler K, et al. Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes. Stem Cells. 2015;33:2973-84 pubmed publisher
    ..Previous studies demonstrated that the nitric oxide (NO), cyclic GMP (cGMP), and protein kinase G (PKG) signaling pathway can inhibit cardiac hypertrophy and thus improve cardiac function...
  68. Murphy T, Kanagarajah A, Toemoe S, Bertrand P, Grayson T, Britton F, et al. TRPV3 expression and vasodilator function in isolated uterine radial arteries from non-pregnant and pregnant rats. Vascul Pharmacol. 2016;83:66-77 pubmed publisher
    ..In radial arteries from non-pregnant rats only, inhibition of NOS and sGC, or PKG, enhanced carvacrol-mediated vasodilation...
  69. Kim H, Kim H, Jung M, Kwon Y, Kim B. Berberine induces pacemaker potential inhibition via cGMP-dependent ATP-sensitive K+ channels by stimulating mu/delta opioid receptors in cultured interstitial cells of Cajal from mouse small intestine. Mol Med Rep. 2016;14:3985-91 pubmed publisher
    ..1H?[1,2,4] oxadiazolo [4,3?a] quinoxalin?1?one (a guanylate cyclase inhibitor) or KT?5823 [a protein kinase G (PKG) inhibitor] did. In addition, berberine stimulated cyclic guanosine monophosphate (cGMP) production in ICCs...
  70. Leroux A, Schulze J, Biondi R. AGC kinases, mechanisms of regulation ‎and innovative drug development. Semin Cancer Biol. 2018;48:1-17 pubmed publisher
    ..related serine/threonine protein kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG, DMPK, MRCK, ROCK, NDR, LATS, CRIK, MAST, GRK, Sgk494, and YANK, while two other families, Aurora and PLK, are the ..
  71. Fokina K, Dainyak M, Nagradova N, Muronetz V. A study on the complexes between human erythrocyte enzymes participating in the conversions of 1,3-diphosphoglycerate. Arch Biochem Biophys. 1997;345:185-92 pubmed
  72. Muller D, Chiesa A, Mandelli L, De Luca V, De Ronchi D, Jain U, et al. Correlation of a set of gene variants, life events and personality features on adult ADHD severity. J Psychiatr Res. 2010;44:598-604 pubmed publisher
    ..Common polymorphisms within a set of nine important candidate genes (SLC6A3, DBH, DRD4, DRD5, HTR2A, CHRNA7, BDNF, PRKG1 and TAAR9) were genotyped for each subject...
  73. Yang C, Hu S, Zhu S, Wang D, Gao X, Hong J. Characterizing yeast promoters used in Kluyveromyces marxianus. World J Microbiol Biotechnol. 2015;31:1641-6 pubmed publisher
    ..Oxygen conditions had non-significant effect. The results of this study provide important information for fine-tuned pathway construction for the metabolic engineering of K. marxianus. ..
  74. Riquelme J, Westermeier F, Hall A, Vicencio J, Pedrozo Z, Ibacache M, et al. Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism. Pharmacol Res. 2016;103:318-27 pubmed publisher
    ..function recovery, but this effect was reversed when Dex was co-administered with inhibitors of the eNOS/NO/PKG pathway...
  75. Ma Y, Wang J, Yu Y, Schwartz R. PKG-1α mediates GATA4 transcriptional activity. Cell Signal. 2016;28:585-94 pubmed publisher
    ..Here we show that GATA4 transcriptional activity is mediated by cell signaling via cGMP dependent PKG-1α activity. Protein kinase G (PKG), a serine/tyrosine specific kinase is the major effector of cGMP signaling...
  76. Pan F, You J, Liu Y, Qiu X, Yu W, Ma J, et al. Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction. Mol Genet Genomics. 2016;291:2215-2224 pubmed
    ..of T2DMED via regulating 28 different genes and several pathways, including apoptosis, fibrosis, eNOS/cGMP/PKG, and vascular smooth muscle contraction processes, which mainly focused on influencing the functions of the ..
  77. O Halloran D, Altshuler Keylin S, Zhang X, He C, Morales Phan C, Yu Y, et al. Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. Sci Rep. 2017;7:169 pubmed publisher
    ..Previously, the protein kinase G (PKG), EGL-4/PKG-1, was shown necessary for both stages of adaptation and phosphorylation of its target, the beta-type ..
  78. Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J. Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta. J Biol Chem. 2001;276:24153-9 pubmed
    Cyclic GMP-dependent protein kinase I (cGKI) affects the inositol 1,4,5-trisphosphate (InsP(3))-dependent release of intracellular calcium by phosphorylation of IRAG (inositol 1,4,5-trisphophate receptor-associated cGMP kinase substrate)...
  79. Eschricht S, Jarr K, Kuhn C, Lehmann L, Kreusser M, Katus H, et al. Heat-shock-protein 90 protects from downregulation of HIF-1α in calcineurin-induced myocardial hypertrophy. J Mol Cell Cardiol. 2015;85:117-26 pubmed publisher
    ..This effect was mediated by HSP-90 induced stabilization of HIF-1 alpha. Further work is needed to understand this unexpected cardioprotective effect of calcineurin A. ..
  80. Hicks K, Byers P, Quiroga E, Pepin M, Shalhub S. Testing patterns for genetically triggered aortic and arterial aneurysms and dissections at an academic center. J Vasc Surg. 2018;68:701-711 pubmed publisher
    ..COL3A1, and familial thoracic aortic aneurysm panel [ACTA2, COL3A1, TGFBR1, TGFBR2, SMAD3, TGFB2, MYLK, MYH11, and PRKG1 genes]) and by review of the collagen vascular laboratory database for genetic testing results...
  81. Koitabashi N, Aiba T, Hesketh G, Rowell J, Zhang M, Takimoto E, et al. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition. J Mol Cell Cardiol. 2010;48:713-24 pubmed publisher
    ..g. PDE5 inhibition by sildenafil, SIL) activates protein kinase G (PKG) and blunts cardiac pathological hypertrophy...
  82. Siamwala J, Majumder S, Tamilarasan K, Muley A, Reddy S, Kolluru G, et al. Simulated microgravity promotes nitric oxide-supported angiogenesis via the iNOS-cGMP-PKG pathway in macrovascular endothelial cells. FEBS Lett. 2010;584:3415-23 pubmed publisher
    ..Further dissection of nitric oxide downstream signaling confirms that simulated microgravity induces angiogenesis via the cyclic guanosine monophosphate (cGMP)-PKG dependent pathway.
  83. Schwappacher R, Rangaswami H, Su Yuo J, Hassad A, Spitler R, Casteel D. cGMP-dependent protein kinase I? regulates breast cancer cell migration and invasion via interaction with the actin/myosin-associated protein caldesmon. J Cell Sci. 2013;126:1626-36 pubmed publisher
    ..Inhibition of the NO/cGMP/PKG pathway reduced migration and invasion of human breast cancer cells, whereas PKG activation enhanced their motility ..
  84. Ding Y, Yao P, Hong T, Han Z, Zhao B, Chen W. The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain. J Headache Pain. 2017;18:51 pubmed publisher
    ..Western blot and real-time RT-PCR were used to observe the expressions of PKG1 mRNA and protein in the spinal dorsal horn...
  85. Chen C, Jiang X, Gu S, Zhang Z. MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells. Toxicol Lett. 2017;278:38-47 pubmed publisher
    ..of Nrf2-meidtaed oxidative damage in the arsenite-induced malignant transformation, we compared the levels of cGMP, PKG and oxidative damage-related indicators between arsenic-transformed cells and control cells...
  86. Song Q, Ni J, Jiang H, Shi Z. Sildenafil improves blood perfusion in steroid-induced avascular necrosis of femoral head in rabbits via a protein kinase G-dependent mechanism. Acta Orthop Traumatol Turc. 2017;51:398-403 pubmed publisher
    ..against avascular necrosis of femoral head (ANFH) in a rabbit model, and to study the role of protein kinase G (PKG) pathway and vascular endothelial growth factor (VEGF) in ANFH...
  87. Pakhomov N, Pustovit K, Potekhina V, Filatova T, Kuzmin V, Abramochkin D. Negative inotropic effects of diadenosine tetraphosphate are mediated by protein kinase C and phosphodiesterases stimulation in the rat heart. Eur J Pharmacol. 2018;820:97-105 pubmed publisher
    ..suggesting that Ap4A-induced inhibitory effects in the rat heart are mediated by PKC, but not by NO/sGC/PKG-related signaling pathway...
  88. Gao Y, Dhanakoti S, Tolsa J, Raj J. Role of protein kinase G in nitric oxide- and cGMP-induced relaxation of newborn ovine pulmonary veins. J Appl Physiol (1985). 1999;87:993-8 pubmed
    In a variety of systemic blood vessels, protein kinase G (PKG) plays a critical role in mediating relaxation induced by agents that elevate cGMP, such as nitric oxide...
  89. Sellak H, Yang X, Cao X, Cornwell T, Soff G, Lincoln T. Sp1 transcription factor as a molecular target for nitric oxide-- and cyclic nucleotide--mediated suppression of cGMP-dependent protein kinase-Ialpha expression in vascular smooth muscle cells. Circ Res. 2002;90:405-12 pubmed
    cGMP-dependent protein kinase (PKG) expression is highly variable and decreases in cultured vascular smooth muscle cells (VSMCs), exposure of cells to nitric oxide (NO), or in response to balloon catheter injury in vivo...
  90. Hou Y, Lascola J, Dulin N, Ye R, Browning D. Activation of cGMP-dependent protein kinase by protein kinase C. J Biol Chem. 2003;278:16706-12 pubmed
    The cGMP-dependent protein kinases (PKG) are emerging as important components of mainstream signal transduction pathways...
  91. Khavandi K, Baylie R, Sugden S, Ahmed M, Csató V, Eaton P, et al. Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels. Sci Signal. 2016;9:ra100 pubmed publisher
    ..report that physiological intraluminal pressure within resistance arteries activated cGMP-dependent protein kinase (PKG) in VSMCs through oxidant-induced formation of an intermolecular disulfide bond between cysteine residues...
  92. Li S, Pan Y, Ke R, Xie X, Zhai C, Shi W, et al. Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells. Sci Rep. 2017;7:6088 pubmed publisher
    ..and consequent TRPC6 up-regulation in PASMCs, while these inhibitory effects of sildenafil were abolished by PKG inhibitor Rp-8Br-cGMPs...