Genomes and Genes
Gene Symbol: PRKCQ
Description: protein kinase C, theta
Alias: PRKCT, nPKC-theta, protein kinase C theta type
- Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathwaysR Zidovetzki
Department of Biology and Neuroscience, University of California, Riverside 92521, USA
AIDS Res Hum Retroviruses 14:825-33. 1998..Both the Tat-induced increase in intracellular cAMP and IL-6 mRNA levels in CNS-ECs may play a role in altering the blood-brain barrier and thereby inducing pathology often observed in AIDS dementia...
- Shared and distinct genetic variants in type 1 diabetes and celiac diseaseDeborah J Smyth
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
N Engl J Med 359:2767-77. 2008..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
- Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytesK Conant
Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
J Virol 70:1384-9. 1996..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
- Common variants at CD40 and other loci confer risk of rheumatoid arthritisSoumya Raychaudhuri
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nat Genet 40:1216-23. 2008..0035 replication, P = 1.1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0...
- Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cellsS P Hehner
Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
J Immunol 164:3829-36. 2000..Vav/PKC theta-induced transcription from the IL-4 promoter was almost completely abrogated by mutation of either the P1 or the PRE-I element within the entire IL-4 promoter...
- Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk lociJason D Cooper
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Nat Genet 40:1399-401. 2008..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).
- Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB inductionYin Liu
Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Biochem J 361:255-65. 2002..These findings expand our understanding of the roles of phosphorylation in novel PKCs, and indicate that PKC-theta is a constitutively competent kinase as a consequence of constitutive phosphorylation of its activation loop...
- HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytesI W Park
Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
Blood 97:352-8. 2001..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
- Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase CFlavia C Nery
Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, C P 6192, 13084 971 Campinas, SP, Brasil
J Biol Chem 279:11444-55. 2004..These events associate Ki-1/57 with the RACK1/PKC pathway and may be important for the regulation of its cellular functions...
- NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-thetaN Coudronniere
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 97:3394-9. 2000..These findings identify a unique PKCtheta-mediated pathway for the costimulatory action of CD28, which involves activation of the IkappaB-kinase beta/IkappaB/NF-kappaB-signaling cascade...
- Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domainS Witte
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Biol Chem 275:1902-9. 2000..These findings suggest that PICOT and its evolutionary conserved homologues may interact with PKC-related kinases in multiple organisms and, second, that it plays a role in regulating the function of the thioredoxin system...
- HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular systemH Idriss
Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
Int J Biochem Cell Biol 31:1443-52. 1999..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
- Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cellsRina Barouch-Bentov
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
J Immunol 175:5126-34. 2005....
- Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytesNikolaus Thuille
Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
EMBO J 24:3869-80. 2005..We conclude that autophosphorylation of PKCtheta at Thr-219 plays an important role in the correct targeting and cellular function of PKCtheta upon antigen receptor ligation...
- Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathwayA Badou
Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
J Virol 74:10551-62. 2000..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
- Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endotheliumM B Huang
Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
J Acquir Immune Defic Syndr 25:375-89. 2000....
- PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytesZ Sun
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
Nature 404:402-7. 2000..These results indicate that PKC-theta functions in a unique pathway that links the TCR signalling complex to the activation of NF-kappaB in mature T lymphocytes...
- Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase CA Jakobovits
Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
EMBO J 9:1165-70. 1990..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth...
- A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influxC L Ruegg
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Cell Immunol 137:1-13. 1991....
- Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cellsG Baier
La Jolla Institute for Allergy and Immunology, California 92037
J Biol Chem 268:4997-5004. 1993..Thus, PKC theta represents an additional member of the PKC family, and its predominant expression in hematopoietic cells suggests that it may play a role in signal transduction and growth regulatory pathways unique to these cells...
- Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary reportS Gupta
Division of Basic and Clinical Immunology, University of California, Irvine 92717
Int J Immunopharmacol 16:197-204. 1994..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
- Selective modulation of protein kinase C-theta during T-cell activationC R Monks
Division of Basic Sciences, National Jewish Center for Immunology, Denver, Colorado 80206, USA
Nature 385:83-6. 1997..Several modes of partial T-cell activation that failed to cause PKC-theta translocation also failed to cause T-cell proliferation, further suggesting the involvement of PKC-theta in T-cell activation...
- Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41C L Ruegg
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
J Immunol 144:3928-35. 1990....
- HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -deltaYamina Bennasser
Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
FASEB J 16:546-54. 2002..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
- In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46A M Holmes
Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Arch Biochem Biophys 335:8-12. 1996..Several Tat peptides, containing serine at position 46, are the only ones which are phosphorylated at significant rates. Several other Tat peptides containing potential protein kinase C phosphorylation sites are not phosphorylated...
- PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCthetaKelly Ann Sheppard
Inflammation Department, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
FEBS Lett 574:37-41. 2004....
- Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cellsB Bauer
Department of Medical Biology and Human Genetics, University of Innsbruck, A 6020 Innsbruck, Austria
J Biol Chem 276:31627-34. 2001..Taken together, these findings suggest a direct cross-talk between PKC theta and Akt1 in Jurkat T cells...
- CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1Donghai Wang
Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
Mol Cell Biol 24:164-71. 2004..Together, these results indicate that CARMA1 mediates CD3/CD28 costimulation-induced NF-kappaB activation by recruiting downstream signaling components into the immunological synapse...
- HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replicationAlison L Greenway
Macfarlane Burnet Institute for Medical Research and Public Health, Cnr Commercial and Punt Roads, Melbourne, Victoria 3004, Australia
J Biosci 28:323-35. 2003....
- Developmental regulation of a protein kinase C isoform localized in the neuromuscular junctionL Hilgenberg
Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn 11203, USA
J Cell Sci 108:51-61. 1995..The message encoding the nPKC theta isoform, a member of the novel calcium-independent class of PKCs, has recently been shown to be abundant in ..
- Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker ratsYanbin Zheng
Section of Endocrinology, The University of Chicago, 900 E 57th Street, KCBD Room 8122, Chicago, Illinois 60637, USA
J Endocrinol 203:337-47. 2009..glycogen synthase kinase 3beta (GSK3B), AMPK (PRKAA1 as listed in the MGI Database), and protein kinase C (PRKCQ) in liver tissue extracts was measured by an in vitro kinase assay using various glutathione-S-transferase (GST)-..
- Overexpression of nPKC theta is inhibitory for agrin-induced nicotinic acetylcholine receptor clustering in C2C12 myotubesKathryn Miles
Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
J Neurosci Res 71:188-95. 2003..To address the question whether nPKC theta, a specific PKC isoform restricted in expression to skeletal muscle and localized to neuromuscular junctions, ..
- Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 regionM Sarfarazi
Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
Am J Hum Genet 62:641-52. 1998..A partial list of genes that positionally are considered as candidates includes NET1, PRKCT, ITIH2, IL2RA, IL15RA, IT1H2, hGATA3, the mRNA for open reading frame KIAA0019, and the gene for D123 protein.
- Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritisKlaus Stark
Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
Ann N Y Acad Sci 1193:10-4. 2010..susceptibility genes like HLA-DRB1, PTPN22, STAT4, TRAF1/C5, OLIG3/TNFAIP3, CD40, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, IL2RB, and KIF5A-PIP4K2C. These association signals explain more than 50% of the genetic influence on RA...
- Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasisYonghong Li
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Semin Immunol 21:318-27. 2009..for at least ten non-HLA related risk genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for ..
- A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscleS Osada
Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
Mol Cell Biol 12:3930-8. 1992..This cDNA encodes a protein, nPKC theta, which consists of 707 amino acid residues and showed the highest sequence similarity to nPKC delta (67...
- Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumoursPetra Gromova
Laboratory of Neurophysiology, Faculty of Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
J Cell Mol Med 13:1536-48. 2009..Gja1/Cx43, Gpc6, Gpr133, Pacrg, Pde3a, Prkar2b, Prkcq/Pkce, Rasd2, Spry4 and Tpbg/5T4 were found to be up-regulated...
- Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activationA Asada
Integrative Projects, Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194, Japan
J Biol Chem 273:28392-8. 1998..These results indicate that activation of nPKC, especially nPKC-theta, induces apoptosis in thymocytes and that calcineurin activation regulates the apoptosis...
- Common and different genetic background for rheumatoid arthritis and coeliac diseaseMarieke J H Coenen
Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Hum Mol Genet 18:4195-203. 2009..Dutch and UK data sets, shared association with six loci (TNFAIP3, IL2/IL21, SH2B3, LPP, MMEL1/TNFRSF14 and PFKFB3/PRKCQ) was observed in both RA and CD cohorts...
- REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritisPeter K Gregersen
The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
Nat Genet 41:820-3. 2009..properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.
- Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native populationH S El-Gabalawy
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Genes Immun 12:568-74. 2011..been associated with RA, including PTPN22, TRAF1-C5, CTLA4, PADI4, STAT4, FCRL3, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, KIF5A-PIP4K2C, IL2RB, TNFAIP3, IL10-1082G/A and REL...
- PKCtheta is required for the activation of human T lymphocytes induced by CD43 engagementRoxana del Rio
Instituto de Biotecnología Universidad Nacional Autónoma de México, AP 510 3 Cuernavaca, MOR 62250, Mexico
Biochem Biophys Res Commun 325:133-43. 2004..Together, these data suggest that PKCtheta; plays a critical role in the co-stimulatory functions of CD43 in human T cells...
- Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activationLiansheng Sun
Division of Hematology and Thromboembolic Diseases, Temple University School of Medicine, 3400 N Broad St, OMS 300, Philadelphia, PA 19140, USA
Blood 103:948-54. 2004....
- Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C thetaJames G Burchfield
Cell Signalling Group, Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
J Biol Chem 279:18623-32. 2004..Our data identify Ndrg2 as a novel insulin-dependent phosphoprotein and suggest that PKC may inhibit insulin action in part by reducing its phosphorylation by Akt...
- Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytesElissa L Sutcliffe
Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Mol Cell 41:704-19. 2011..Our results provide a molecular explanation for the role of PKC-θ not only in normal T cell function, but also in circumstances of its ectopic expression in cancer...
- Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistanceSuryakant K Niture
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Cell Sci 122:4452-64. 2009....
- Cutaneous anaplastic large cell lymphoma and peripheral T-cell lymphoma NOS show distinct chromosomal alterations and differential expression of chemokine receptors and apoptosis regulatorsMarloes S van Kester
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
J Invest Dermatol 130:563-75. 2010..Furthermore, C-ALCL and PTL-NOS showed aberrant expression of distinct genes implicated in apoptosis and proliferation, such as IRF4/MUM1 and PRKCQ, which may account for differences in clinical aggressiveness.
- T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C thetaSu Yi Tseng
Program in Molecular Pathogenesis, Helen L and Martin S Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Immunol 181:4852-63. 2008..Thus, the T cell-DC interface contains dynamic costimulatory foci that share characteristics of microclusters and cSMACs...
- Lipid raft assembly and Lck recruitment in TRAIL costimulation mediates NF-κB activation and T cell proliferationShih Chia Huang
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
J Immunol 186:931-9. 2011..Our results suggest that in TRAIL costimulation, lipid raft recruitment of Lck integrates mitogenic NF-κB-dependent signals from the TCR and TRAIL in T lymphocytes...
- A238L inhibits NF-ATc2, NF-kappa B, and c-Jun activation through a novel mechanism involving protein kinase C-theta-mediated up-regulation of the amino-terminal transactivation domain of p300Aitor G Granja
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
J Immunol 180:2429-42. 2008..These findings provide new strategies to develop therapies potentially useful in the control of disorders related to p300 deregulation...
- NKG2D costimulates human V gamma 9V delta 2 T cell antitumor cytotoxicity through protein kinase C theta-dependent modulation of early TCR-induced calcium and transduction signalsSteven Nedellec
Institut National de la Sante et de la Recherche Medicale, U892, Centre de Recherche en Cancérologie Nantes Angers, Nantes, France
J Immunol 185:55-63. 2010..Therefore, this study identifies a new mechanism regulating Vgamma9Vdelta2 T cell functional plasticity through fine-tuning of early signal transduction events...
- Expression of protein kinase C family in human hepatocellular carcinomaHsiu Chin Lu
Department of Laboratory Medicine, Medical University Hospital, Institute of Clinical Research, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Pathol Oncol Res 16:385-91. 2010..009), and the down-regulated expression of PKCbetaII is associated with HBV infection (p = 0.035). Our findings suggest particular roles of the two PKC isoenzymes in the hepatocarcinogenesis of human HCC...
- Protein kinase C-theta in platelet activationSagit Cohen
The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
FEBS Lett 585:3208-15. 2011..The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation...
- Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell functionKole T Roybal
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Sci Signal 3:pe24. 2010..with that of other PKC family members? What are the functionally critical distinctions in the similar signaling systems of effector and regulatory T cells? Does the divergent localization of PKC-theta in regulatory T cells drive function?..
- The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKCtheta and ERK pathwaysGilles Despouy
Institut Curie, Centre de Recherche, Paris, France
Blood 110:4406-16. 2007..Altogether, our data demonstrated that TCL1 inhibits AICD in T cells by blocking PKCtheta and ERK activation, upon cellular activation...
- Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3Christine Teixeira
Department of Biochemistry, University of Alberta, Edmonton, Canada
Blood 102:1414-20. 2003..A convergent DAG signaling system could be important in fine-tuning Ras signaling during B-cell development or during the humoral immune response...
- Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cellsShangwu Chen
Immunology Group, Institute of Cell and Molecular Sciences, St Barts and The Royal London School of Medicine, Queen Mary University of London, London EC1A 7BE, UK
Int Immunol 15:403-9. 2003..These results suggest that CIS regulates PKC activation, and that this may be important for the activation of both the AP-1 and NF-kappaB pathways in TCR signaling...
- Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cellsS Tang
Vascular Biology Unit and Cardiovascular Division, Department of Medicine, Beth Israel Hospital and the Harvard Thorndike Laboratories, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 272:28704-11. 1997..Thus, PKCtheta is required for multiple processes essential for angiogenesis and wound repair, including endothelial mitosis, maintenance of a normal actin cytoskeleton, and formation of an enclosed tube...
- Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BADM Villalba
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
J Immunol 166:5955-63. 2001..We provide evidence that the distant Bcl-2 family member, BAD, is a PKCtheta substrate, is phosphorylated by TCR stimulation, and can mediate at least in part the anti-apoptotic effect of PKCtheta...
- Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cellsP Borgatti
Division of Signal Transduction, Harvard Institute of Medicine, Beth Israel Hospital, Boston, Massachusettes 02115, USA
Biochem Biophys Res Commun 242:332-7. 1998..Taken together, these findings demonstrate that extracellular Tat shows a cytokine-like activity in PC12 cells, being able to trigger an intracellular signalling cascade which involves PKC-alpha, -epsilon, and -zeta...
- Effect of serine and tyrosine phosphorylation on retroviral proteinase substratesJ Tozser
Department of Biochemistry and Molecular Biology, University Medical School of Debrecen, Hungary
Eur J Biochem 265:423-9. 1999....
- Protein kinase C-theta phosphorylation of moesin in the actin-binding sequenceS F Pietromonaco
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
J Biol Chem 273:7594-603. 1998..It appears likely that this activity corresponds to a specific intracellular pathway controlling the function of moesin as well as other ERM proteins...
- SPAK, a STE20/SPS1-related kinase that activates the p38 pathwayA M Johnston
Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Parkville 3050, Australia
Oncogene 19:4290-7. 2000..Oncogene (2000) 19, 4290 - 4297..
- Differential expression of protein kinase C isoform transcripts in human hematopoietic progenitors undergoing differentiationS Oshevski
Hopital Paul Brousse, INSERM U 268, Villejuif Cedex, 94807, France
Biochem Biophys Res Commun 263:603-9. 1999....
- Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structuresN Oshiro
Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
J Biol Chem 273:34663-6. 1998..These results indicate that Rho-kinase regulates moesin phosphorylation downstream of Rho in vivo and that the phosphorylation of moesin by Rho-kinase plays a crucial role in the formation of microvilli-like structures...
- 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cellsM V Autieri
Department of Cardiology and Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
DNA Cell Biol 18:555-64. 1999..Thus, 14-3-3gamma may represent a signal transduction protein that is regulated transcriptionally and post-transcriptionally by growth factors...
- Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fynD Ron
Telik, Inc, South San Francisco, California 94080, USA
J Biol Chem 274:19003-10. 1999....
- Comparative mapping of a region on chromosome 10 containing QTL for reproduction in swineD J Nonneman
USDA, ARS, US Meat Animal Research Center, Spur 18D, Clay Center, NB, USA
Anim Genet 34:42-6. 2003..Six genes from human chromosome 10p (AKR1C2, PRKCQ, ITIH2, ATP5C1, PIP5K2A and GAD2) were mapped in the MARC swine mapping population...
- Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and functionN Meller
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Mol Cell Biol 16:5782-91. 1996..The interaction between 14-3-3 and PKC theta may represent an important general mechanism for regulating PKC-dependent signals and, more specifically, PKC theta-mediated functions during T-cell activation...
- Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigensBarbara Cipriani
Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Immunol 169:5761-70. 2002..We conclude that the gammadelta T cell response to phosphoantigens is regulated by both novel and conventional PKC isoforms, with PKCtheta being more responsive to ligand stimulation and PKCalpha/beta to growth-factor availability...
- Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinasesDavid Crosby
Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
J Biol Chem 277:9958-65. 2002..We propose a reciprocal feedback interaction between Btk and PKCtheta; in platelets, in which PKCtheta; positively modulates activity of Btk, which in turn feeds back negatively upon PKCtheta;...
- [HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]Y Bennasser
Laboratoire d Immuno Virologie, Université Paul Sabatier 118, route de Narbonne, 31062 Toulouse
J Soc Biol 195:319-26. 2001..Using microspectrofluorimetry and confocal microscopy, we also show that Tat induces a calcium influx...
- Regulation of retinoid X receptor responsive element-dependent transcription in T lymphocytes by Ser/Thr phosphatases: functional divergence of protein kinase C (PKC)theta; and PKC alpha in mediating calcineurin-induced transactivationMohammad Ishaq
Laboratory of Molecular Cell Biology, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
J Immunol 169:732-8. 2002..Thus, PKC theta; and PKC alpha may function as positive and negative modulators, respectively, of CN-regulated RXRE-dependent transcription during T cell activation...
- Human immunodeficiency virus induces phosphorylation of its cell surface receptorA P Fields
Johns Hopkins Oncology Center, Baltimore, Maryland 21231
Nature 333:278-80. 1988..These results indicate a possible role for HIV-induced CD4 phosphorylation in viral entry and identify a potential target for antiviral therapy...
- The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis RegisterDarren Plant
ARC Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Rheumatology (Oxford) 50:78-84. 2011..We therefore sought to investigate the role of recently identified RA susceptibility SNP markers in predicting erosive outcome in patients with recent-onset inflammatory polyarthritis (IP)...
- The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathwayI H Chowdhury
Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan
Virology 176:126-32. 1990....
- Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritisAnne Hinks
Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
Ann Rheum Dis 69:1049-53. 2010..Rheumatoid arthritis (RA) is an autoimmune disease that shares similar clinical and pathological features with JIA and, therefore, recently identified confirmed RA susceptibility loci are also excellent JIA candidate loci...
- HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cellsN Chirmule
Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030, USA
J Biol Chem 270:19364-9. 1995..g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion...
- PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesisKarine Belguise
Department of Biochemistry and Women s Health Interdisciplinary Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Clin Invest 117:4009-21. 2007....
- Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analoguesT Jones
MRC Toxicology Unit, University of Leicester, UK
Biochem Pharmacol 53:1413-8. 1997..CGP 41251 had no effect on PKC-theta in either experimental design. The results show that some, but not all, staurosporine analogues share the partial phorbol ester-agonistic PKC-translocatory activity of the parent molecule...
- Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residuesJ S Hayflick
ICOS Corporation, Bothell, Washington 98021, USA
J Biol Chem 272:22207-14. 1997..This study delineates separable regions and amino acid residues within the cytoplasmic portion of ICAM-3 that are important for T cell function...
- Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTLAllison M Beal
Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Immunol 181:4815-24. 2008..Thus, formation of a stable pSMAC, which is partially controlled by protein kinase Ctheta, functions to confine the released lytic molecules at the synaptic interface and to enhance the effectiveness of target cell lysis...
- Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membraneFrancesca Giannoni
Department of Medicine, University of California, San Diego, CA 92093, USA
J Immunol 174:3204-11. 2005..Engineered aAPC may have immediate application for basic and clinical immunology studies pertaining to modulation of T cells ex vivo...
- PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activationKi Young Lee
Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
Science 308:114-8. 2005..Hence, PDK1 plays a critical role by nucleating the TCR-induced NF-kappaB activation pathway in T cells...
- Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillationsChul Hoon Kim
NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:25409-15. 2005..The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839...
- HIV envelope gp120 activates human arterial smooth muscle cellsA D Schecter
Zena and Michael A Wiener Cardiovascular Institute and Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 98:10142-7. 2001..The activation of smooth muscle cells by gp120 may play an important role in the vascular, thrombotic, and inflammatory responses to HIV infection...
- Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cellsSanthakumar Manicassamy
Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
J Mol Biol 355:347-59. 2006..Thus, PKC-theta can both positively and negatively regulate the Ca2+ influx that is critical for NFAT activity...
- The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28A Khoshnan
Division of Clinical Immunology and Allergy, Department of Medicine, Center for Health Sciences, University of California, Los Angeles, CA 90095, USA
J Immunol 165:6933-40. 2000..Taken together, these data show that the activation of PKCtheta by the TCR and CD28 plays an important role in the assembly and activation of IKK complexes in the T cell membrane...
- Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targetingDietlinde Wolf
University of Miami, Miller School of Medicine, Department of Microbiology and Immunology, BCRI 739, Miami, FL 33136, USA
Virology 370:45-54. 2008..We conclude that the activation of nPKCs by Nef is required to increase viral replication/infectivity and direct the subcellular localization of Nef...
- Membrane raft association of CD47 is necessary for actin polymerization and protein kinase C theta translocation in its synergistic activation of T cellsR A Rebres
Center for Host Pathogen Interactions, University of California, San Francisco 94143, USA
J Biol Chem 276:7672-80. 2001..Full synergy with TCR requires CD47 localization to membrane rafts where ligation leads to TCR-independent signals causing actin polymerization and PKCtheta translocation...
- Theta-isoform of PKC is required for alterations in cytoskeletal dynamics and barrier permeability in intestinal epithelium: a novel function for PKC-thetaA Banan
Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
Am J Physiol Cell Physiol 287:C218-34. 2004..The ability to alter the cytoskeletal and barrier dynamics is a unique function not previously attributed to PKC-theta...
- Impaired activation of platelets lacking protein kinase C-theta isoformBela Nagy
Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Blood 113:2557-67. 2009..In conclusion, PKC-theta isoform plays a significant role in platelet functional responses downstream of PAR and GPVI receptors...
- CD28 plays a critical role in the segregation of PKC theta within the immunologic synapseJianyong Huang
Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 99:9369-73. 2002....
- PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemiaMaria Pia Felli
Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Roma, Italy
Oncogene 24:992-1000. 2005..This paper therefore suggests that PKC theta mediates the activation of NF-kappa B by pre-TCR in immature thymocytes and contributes to the development of Notch3-dependent T-cell lymphoma...
- Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and plateletsJ D Chang
Harvard Thorndike Laboratory, Department of Medicine Cardiovascular Division, Beth Israel Hospital, Boston, Massachusetts 02215
J Biol Chem 268:14208-14. 1993..These findings extend the PKC family and suggest a novel approach to the study of diversity within this pathway of intracellular signal transduction...
- Stimulus-induced phosphorylation of PKC theta at the C-terminal hydrophobic-motif in human T lymphocytesMichael Freeley
Department of Biochemistry, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
Biochem Biophys Res Commun 334:619-30. 2005..However, hydrophobic-motif phosphorylation does not appear to control membrane translocation, suggesting that this site may control other aspects of PKC theta signalling...
- Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytesG Werlen
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093 0636, USA
EMBO J 17:3101-11. 1998..These results indicate that PKC isozymes have distinct biological functions and suggest that synergistic JNK activation is an important function for PKC-theta in T-cell activation...
- New perspectives on PKCtheta, a member of the novel subfamily of protein kinase CN Meller
Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
Stem Cells 16:178-92. 1998..Here, we review recent progress in the study of PKCtheta and discuss its potential role in various cellular responses...
- Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell deathMarcin Kaminski
Tumor Immunology Program, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Mol Cell Biol 27:3625-39. 2007..Similar results were obtained when metformin, an antidiabetic drug and mild complex I inhibitor, was used. Thus, we demonstrate for the first time that PKCtheta-dependent ROS generation by mitochondrial complex I is essential for AICD...
- IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase CN A Parada
Department of Medicine, Pulmonary Center, Boston University School of Medicine, MA 02118, USA
Cell Immunol 168:100-6. 1996..Taken together, these data suggest a role for PKC in CD4-mediated migratory responses...
- MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAEAnthony Bretscher; Fiscal Year: 1992..If so, it should set the stage for the thorough analysis of these important cytoskeletal elements...
- Genetic Predictors of Early Atherosclerosis in SLEElizabeth Karlson; Fiscal Year: 2007..abstract_text> ..
- Clinical Risk Prediction Modeling in Rheumatoid ArthritisElizabeth W Karlson; Fiscal Year: 2010..This information will be used to develop personally tailored physical activity counseling to promote health and reduce cardiovascular risk of patients with RA. ..
- Protective Mechanism of an Anti-Inflammatory Herbal MixAli Banan; Fiscal Year: 2006..abstract_text> ..
- MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAEAnthony Bretscher; Fiscal Year: 2005..Since homologues of molecules critical for these processes in yeast have been associated with defects in mice and in human diseases, this work should be of general relevance. ..
- EGF, Oxidants & Intestinal Barrier IntegrityAli Banan; Fiscal Year: 2006..abstract_text> ..
- MICROFILAMENT ORGANIZATION AND REGULATIONAnthony Bretscher; Fiscal Year: 2006..This work should provide an integrated approach to the structure and function of the apical aspect of polarized cells. ..
- Microfilaments in Budding Yeast and the NematodeAnthony Bretscher; Fiscal Year: 2009..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
- Clinical Risk Prediction Modeling in Rheumatoid ArthritisElizabeth Karlson; Fiscal Year: 2009..This information will be used to develop personally tailored physical activity counseling to promote health and reduce cardiovascular risk of patients with RA. ..
- Microfilaments in Budding Yeast and the NematodeAnthony Bretscher; Fiscal Year: 2009..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
- Hormone, cytokine, and genetic risks for RA in womenElizabeth Karlson; Fiscal Year: 2007..Ultimately, this study could lead to the identification of potential targets for therapeutic interventions to treat RA or to reduce the risk of this serious autoimmune disease. ..
- MICROFILAMENT ORGANIZATION AND REGULATIONAnthony Bretscher; Fiscal Year: 2007..Moreover, ezrin is elevated in many tumors, and an elevated level of ezrin has been shown to be necessary for metastasis in some tumor cell lines. ..
- Microfilaments in Budding Yeast and the NematodeAnthony Bretscher; Fiscal Year: 2007..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
- ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RAElizabeth Karlson; Fiscal Year: 2002..RA will be confirmed by a screening questionnaire regarding rheumatic symptoms and review of medical records. The study will identify potentially modifiable risk factors for primary prevention of RA. ..
- MICROFILAMENT ORGANIZATION AND REGULATIONAnthony Bretscher; Fiscal Year: 2002..g. EBP50) as well as different conformational states of ezrin. These studies will provide a comprehensive analysis of ezrin and EBP50 and the role they play in the structure and function of the apical membrane. ..
- MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAEAnthony Bretscher; Fiscal Year: 2001....
- MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAEAnthony Bretscher; Fiscal Year: 1993..These studies should greatly advance our goal of uncovering the function of actin and its associated proteins in yeast...
- MICROFILAMENT ORGANIZATION AND REGULATIONAnthony Bretscher; Fiscal Year: 1993..The work set out in this study focusses on three proteins that play key roles in microfilament organizations. The results should provide some important basic information about the regulation and molecular organization of microfilaments...