PRKCQ

Summary

Gene Symbol: PRKCQ
Description: protein kinase C, theta
Alias: PRKCT, nPKC-theta, protein kinase C theta type
Species: human

Top Publications

  1. ncbi Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways
    R Zidovetzki
    Department of Biology and Neuroscience, University of California, Riverside 92521, USA
    AIDS Res Hum Retroviruses 14:825-33. 1998
  2. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
  3. pmc CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
    Donghai Wang
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Mol Cell Biol 24:164-71. 2004
  4. ncbi Selective modulation of protein kinase C-theta during T-cell activation
    C R Monks
    Division of Basic Sciences, National Jewish Center for Immunology, Denver, Colorado 80206, USA
    Nature 385:83-6. 1997
  5. ncbi Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells
    B Bauer
    Department of Medical Biology and Human Genetics, University of Innsbruck, A 6020 Innsbruck, Austria
    J Biol Chem 276:31627-34. 2001
  6. ncbi PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
    Maria Pia Felli
    Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Roma, Italy
    Oncogene 24:992-1000. 2005
  7. pmc NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
    N Coudronniere
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 97:3394-9. 2000
  8. pmc Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction
    Yin Liu
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Biochem J 361:255-65. 2002
  9. ncbi Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells
    Rina Barouch-Bentov
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:5126-34. 2005
  10. ncbi Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL
    Santhakumar Manicassamy
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 176:6709-16. 2006

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways
    R Zidovetzki
    Department of Biology and Neuroscience, University of California, Riverside 92521, USA
    AIDS Res Hum Retroviruses 14:825-33. 1998
    ..Both the Tat-induced increase in intracellular cAMP and IL-6 mRNA levels in CNS-ECs may play a role in altering the blood-brain barrier and thereby inducing pathology often observed in AIDS dementia...
  2. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  3. pmc CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
    Donghai Wang
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Mol Cell Biol 24:164-71. 2004
    ..Together, these results indicate that CARMA1 mediates CD3/CD28 costimulation-induced NF-kappaB activation by recruiting downstream signaling components into the immunological synapse...
  4. ncbi Selective modulation of protein kinase C-theta during T-cell activation
    C R Monks
    Division of Basic Sciences, National Jewish Center for Immunology, Denver, Colorado 80206, USA
    Nature 385:83-6. 1997
    ..Several modes of partial T-cell activation that failed to cause PKC-theta translocation also failed to cause T-cell proliferation, further suggesting the involvement of PKC-theta in T-cell activation...
  5. ncbi Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells
    B Bauer
    Department of Medical Biology and Human Genetics, University of Innsbruck, A 6020 Innsbruck, Austria
    J Biol Chem 276:31627-34. 2001
    ..Taken together, these findings suggest a direct cross-talk between PKC theta and Akt1 in Jurkat T cells...
  6. ncbi PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
    Maria Pia Felli
    Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Roma, Italy
    Oncogene 24:992-1000. 2005
    ..This paper therefore suggests that PKC theta mediates the activation of NF-kappa B by pre-TCR in immature thymocytes and contributes to the development of Notch3-dependent T-cell lymphoma...
  7. pmc NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
    N Coudronniere
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 97:3394-9. 2000
    ..These findings identify a unique PKCtheta-mediated pathway for the costimulatory action of CD28, which involves activation of the IkappaB-kinase beta/IkappaB/NF-kappaB-signaling cascade...
  8. pmc Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction
    Yin Liu
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Biochem J 361:255-65. 2002
    ..These findings expand our understanding of the roles of phosphorylation in novel PKCs, and indicate that PKC-theta is a constitutively competent kinase as a consequence of constitutive phosphorylation of its activation loop...
  9. ncbi Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells
    Rina Barouch-Bentov
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:5126-34. 2005
    ....
  10. ncbi Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL
    Santhakumar Manicassamy
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 176:6709-16. 2006
    ..Thus, the PKC-theta-mediated signals may function not only in the initial activation of naive CD4+ T cells, but also in their survival during T cell activation by regulating Bcl-xL levels through NF-kappaB and AP-1 pathways...
  11. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
  12. pmc Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta
    Wing Yiu Lee
    Medical Research Council, Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 285:23889-98. 2010
    ....
  13. pmc Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome
    Miren David
    Instituto de Investigaciones Biomedicas, Madrid Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, c Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 287:21416-28. 2012
    ..5, K(v)β1.3, the receptor for activated C kinase (RACK1), PKCβI, PKCβII, and PKCθ in HEK293 cells. A very similar K(v)1.5 channelosome was found in rat ventricular tissue but not in atrial tissue...
  14. pmc Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes
    Nikolaus Thuille
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    EMBO J 24:3869-80. 2005
    ..We conclude that autophosphorylation of PKCtheta at Thr-219 plays an important role in the correct targeting and cellular function of PKCtheta upon antigen receptor ligation...
  15. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008
    ..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).
  16. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..0035 replication, P = 1.1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0...
  17. pmc Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways
    Prashant B Shambharkar
    Department of Molecular and Cellular Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 26:1794-805. 2007
    ..Thus, our study provides the biochemical and genetic evidence that phosphorylation of IKKalpha/beta and ubiquitination of NEMO are regulated by two distinct pathways upon TCR stimulation...
  18. ncbi 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells
    M V Autieri
    Department of Cardiology and Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    DNA Cell Biol 18:555-64. 1999
    ..Thus, 14-3-3gamma may represent a signal transduction protein that is regulated transcriptionally and post-transcriptionally by growth factors...
  19. pmc Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death
    Marcin Kaminski
    Tumor Immunology Program, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cell Biol 27:3625-39. 2007
    ..Similar results were obtained when metformin, an antidiabetic drug and mild complex I inhibitor, was used. Thus, we demonstrate for the first time that PKCtheta-dependent ROS generation by mitochondrial complex I is essential for AICD...
  20. pmc Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function
    N Meller
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Mol Cell Biol 16:5782-91. 1996
    ..The interaction between 14-3-3 and PKC theta may represent an important general mechanism for regulating PKC-dependent signals and, more specifically, PKC theta-mediated functions during T-cell activation...
  21. ncbi Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells
    S P Hehner
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Immunol 164:3829-36. 2000
    ..Vav/PKC theta-induced transcription from the IL-4 promoter was almost completely abrogated by mutation of either the P1 or the PRE-I element within the entire IL-4 promoter...
  22. ncbi Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium
    M B Huang
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Acquir Immune Defic Syndr 25:375-89. 2000
    ....
  23. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
  24. ncbi Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain
    S Witte
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:1902-9. 2000
    ..These findings suggest that PICOT and its evolutionary conserved homologues may interact with PKC-related kinases in multiple organisms and, second, that it plays a role in regulating the function of the thioredoxin system...
  25. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
  26. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
    ....
  27. ncbi Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
    G Baier
    La Jolla Institute for Allergy and Immunology, California 92037
    J Biol Chem 268:4997-5004. 1993
    ..Thus, PKC theta represents an additional member of the PKC family, and its predominant expression in hematopoietic cells suggests that it may play a role in signal transduction and growth regulatory pathways unique to these cells...
  28. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996
    ..Several Tat peptides, containing serine at position 46, are the only ones which are phosphorylated at significant rates. Several other Tat peptides containing potential protein kinase C phosphorylation sites are not phosphorylated...
  29. ncbi Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
    R Datta
    Division of Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:20317-20. 1997
    ..These findings indicate that proteolytic cleavage of PKCtheta by Caspase-3 induces events characteristic of apoptosis...
  30. ncbi HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication
    Alison L Greenway
    Macfarlane Burnet Institute for Medical Research and Public Health, Cnr Commercial and Punt Roads, Melbourne, Victoria 3004, Australia
    J Biosci 28:323-35. 2003
    ....
  31. ncbi PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    Kelly Ann Sheppard
    Inflammation Department, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    FEBS Lett 574:37-41. 2004
    ....
  32. ncbi Developmental regulation of a protein kinase C isoform localized in the neuromuscular junction
    L Hilgenberg
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn 11203, USA
    J Cell Sci 108:51-61. 1995
    ..The message encoding the nPKC theta isoform, a member of the novel calcium-independent class of PKCs, has recently been shown to be abundant in ..
  33. pmc Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats
    Yanbin Zheng
    Section of Endocrinology, The University of Chicago, 900 E 57th Street, KCBD Room 8122, Chicago, Illinois 60637, USA
    J Endocrinol 203:337-47. 2009
    ..glycogen synthase kinase 3beta (GSK3B), AMPK (PRKAA1 as listed in the MGI Database), and protein kinase C (PRKCQ) in liver tissue extracts was measured by an in vitro kinase assay using various glutathione-S-transferase (GST)-..
  34. ncbi Overexpression of nPKC theta is inhibitory for agrin-induced nicotinic acetylcholine receptor clustering in C2C12 myotubes
    Kathryn Miles
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
    J Neurosci Res 71:188-95. 2003
    ..To address the question whether nPKC theta, a specific PKC isoform restricted in expression to skeletal muscle and localized to neuromuscular junctions, ..
  35. pmc Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region
    M Sarfarazi
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
    Am J Hum Genet 62:641-52. 1998
    ..A partial list of genes that positionally are considered as candidates includes NET1, PRKCT, ITIH2, IL2RA, IL15RA, IT1H2, hGATA3, the mRNA for open reading frame KIAA0019, and the gene for D123 protein.
  36. doi Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis
    Klaus Stark
    Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
    Ann N Y Acad Sci 1193:10-4. 2010
    ..susceptibility genes like HLA-DRB1, PTPN22, STAT4, TRAF1/C5, OLIG3/TNFAIP3, CD40, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, IL2RB, and KIF5A-PIP4K2C. These association signals explain more than 50% of the genetic influence on RA...
  37. doi Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Semin Immunol 21:318-27. 2009
    ..for at least ten non-HLA related risk genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for ..
  38. pmc A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle
    S Osada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Mol Cell Biol 12:3930-8. 1992
    ..This cDNA encodes a protein, nPKC theta, which consists of 707 amino acid residues and showed the highest sequence similarity to nPKC delta (67...
  39. doi Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours
    Petra Gromova
    Laboratory of Neurophysiology, Faculty of Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Cell Mol Med 13:1536-48. 2009
    ..Gja1/Cx43, Gpc6, Gpr133, Pacrg, Pde3a, Prkar2b, Prkcq/Pkce, Rasd2, Spry4 and Tpbg/5T4 were found to be up-regulated...
  40. ncbi Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation
    A Asada
    Integrative Projects, Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194, Japan
    J Biol Chem 273:28392-8. 1998
    ..These results indicate that activation of nPKC, especially nPKC-theta, induces apoptosis in thymocytes and that calcineurin activation regulates the apoptosis...
  41. pmc REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
    Peter K Gregersen
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Nat Genet 41:820-3. 2009
    ..properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.
  42. doi Common and different genetic background for rheumatoid arthritis and coeliac disease
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 18:4195-203. 2009
    ..Dutch and UK data sets, shared association with six loci (TNFAIP3, IL2/IL21, SH2B3, LPP, MMEL1/TNFRSF14 and PFKFB3/PRKCQ) was observed in both RA and CD cohorts...
  43. pmc Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation
    Robert V Stahelin
    Department of Chemistry, University of Illinois, Chicago, IL 60607, USA
    J Biol Chem 287:30518-28. 2012
    ..Collectively, these studies establish the C2 domain of PKCθ as a Tyr(P)-binding domain and suggest that the domain may play a major role in PKCθ activation via its Tyr(P) binding...
  44. doi Mechanism of action of salvianolic acid B by module-based network analysis
    Zhenzhen Ren
    School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100102, China
    Biomed Mater Eng 24:1333-40. 2014
    ..effect of Sal B was due to the immune response of T lymphocytes by regulating IL-2 family, CD3E, CD79A, MAP3K7 and PRKCQ. Therefore, the module-based network analysis will be an effective method for better understanding CMM.
  45. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
    ..Recombinant p21-activated kinase hPAK65, a recently proposed relative of the Nef-associated kinase, achieved a comparable result. Taken together, these data suggest that MA is a target of the Nef-associated serine kinase...
  46. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
  47. doi c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Rm 4NN16, 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Mol Cell Biochem 330:23-9. 2009
    ..Collectively, these findings further corroborate the concept that gp120 plays an important role, via involvement of molecules such as c-FLIPL, in apoptotic cell death due to HIV-1 infection...
  48. doi PKC-θ exists in an oxidized inactive form in naive human T cells
    Marina Rode von Essen
    Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Immunol 43:1659-66. 2013
    ..Our observations underscore the existence of major differences in TCR signaling in naïve versus primed T cells. ..
  49. pmc The emerging role of protein kinase Cθ in cytoskeletal signaling
    Izabela Michalczyk
    Laboratory of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland
    J Leukoc Biol 93:319-27. 2013
    ..Comprehensive understanding of cytoskeletal regulation and the cellular "modus operandi" of PKCθ holds promise for improving current therapeutic applications aimed at autoimmune diseases...
  50. pmc NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species
    Vincenzo Giambra
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Nat Med 18:1693-8. 2012
    ....
  51. pmc Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C
    A Jakobovits
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 9:1165-70. 1990
    ..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth...
  52. pmc PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1
    Hirofumi Jono
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 7:e31049. 2012
    ..CARMA1 plays a crucial role in mediating this synergistic effect via TRAF6, thereby resulting in synergistic upregulation of MUC5AC mucin. Thus our study unveils a novel role for CARMA1 in mediating host mucosal innate immune response...
  53. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
    ....
  54. ncbi Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C
    Flavia C Nery
    Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, C P 6192, 13084 971 Campinas, SP, Brasil
    J Biol Chem 279:11444-55. 2004
    ..These events associate Ki-1/57 with the RACK1/PKC pathway and may be important for the regulation of its cellular functions...
  55. ncbi PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
    Z Sun
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Nature 404:402-7. 2000
    ..These results indicate that PKC-theta functions in a unique pathway that links the TCR signalling complex to the activation of NF-kappaB in mature T lymphocytes...
  56. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  57. ncbi Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins
    Y Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 162:7095-101. 1999
    ....
  58. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
    ..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
  59. doi Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes
    Elissa L Sutcliffe
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Mol Cell 41:704-19. 2011
    ..Our results provide a molecular explanation for the role of PKC-θ not only in normal T cell function, but also in circumstances of its ectopic expression in cancer...
  60. doi Cutaneous anaplastic large cell lymphoma and peripheral T-cell lymphoma NOS show distinct chromosomal alterations and differential expression of chemokine receptors and apoptosis regulators
    Marloes S van Kester
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 130:563-75. 2010
    ..Furthermore, C-ALCL and PTL-NOS showed aberrant expression of distinct genes implicated in apoptosis and proliferation, such as IRF4/MUM1 and PRKCQ, which may account for differences in clinical aggressiveness.
  61. ncbi Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD
    M Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 166:5955-63. 2001
    ..We provide evidence that the distant Bcl-2 family member, BAD, is a PKCtheta substrate, is phosphorylated by TCR stimulation, and can mediate at least in part the anti-apoptotic effect of PKCtheta...
  62. ncbi Human immunodeficiency virus induces phosphorylation of its cell surface receptor
    A P Fields
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231
    Nature 333:278-80. 1988
    ..These results indicate a possible role for HIV-induced CD4 phosphorylation in viral entry and identify a potential target for antiviral therapy...
  63. doi Protein kinase C-theta in platelet activation
    Sagit Cohen
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    FEBS Lett 585:3208-15. 2011
    ..The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation...
  64. ncbi Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases
    David Crosby
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:9958-65. 2002
    ..We propose a reciprocal feedback interaction between Btk and PKCtheta; in platelets, in which PKCtheta; positively modulates activity of Btk, which in turn feeds back negatively upon PKCtheta;...
  65. ncbi A238L inhibits NF-ATc2, NF-kappa B, and c-Jun activation through a novel mechanism involving protein kinase C-theta-mediated up-regulation of the amino-terminal transactivation domain of p300
    Aitor G Granja
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 180:2429-42. 2008
    ..These findings provide new strategies to develop therapies potentially useful in the control of disorders related to p300 deregulation...
  66. pmc Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance
    Suryakant K Niture
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cell Sci 122:4452-64. 2009
    ....
  67. doi Expression of protein kinase C family in human hepatocellular carcinoma
    Hsiu Chin Lu
    Department of Laboratory Medicine, Medical University Hospital, Institute of Clinical Research, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Pathol Oncol Res 16:385-91. 2010
    ..009), and the down-regulated expression of PKCbetaII is associated with HBV infection (p = 0.035). Our findings suggest particular roles of the two PKC isoenzymes in the hepatocarcinogenesis of human HCC...
  68. ncbi SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
    A M Johnston
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Parkville 3050, Australia
    Oncogene 19:4290-7. 2000
    ..Oncogene (2000) 19, 4290 - 4297..
  69. ncbi Differential expression of protein kinase C isoform transcripts in human hematopoietic progenitors undergoing differentiation
    S Oshevski
    Hopital Paul Brousse, INSERM U 268, Villejuif Cedex, 94807, France
    Biochem Biophys Res Commun 263:603-9. 1999
    ....
  70. ncbi Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates
    J Tozser
    Department of Biochemistry and Molecular Biology, University Medical School of Debrecen, Hungary
    Eur J Biochem 265:423-9. 1999
    ....
  71. doi Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population
    H S El-Gabalawy
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Genes Immun 12:568-74. 2011
    ..been associated with RA, including PTPN22, TRAF1-C5, CTLA4, PADI4, STAT4, FCRL3, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, KIF5A-PIP4K2C, IL2RB, TNFAIP3, IL10-1082G/A and REL...
  72. pmc T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta
    Su Yi Tseng
    Program in Molecular Pathogenesis, Helen L and Martin S Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 181:4852-63. 2008
    ..Thus, the T cell-DC interface contains dynamic costimulatory foci that share characteristics of microclusters and cSMACs...
  73. doi Lipid raft assembly and Lck recruitment in TRAIL costimulation mediates NF-κB activation and T cell proliferation
    Shih Chia Huang
    Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Immunol 186:931-9. 2011
    ..Our results suggest that in TRAIL costimulation, lipid raft recruitment of Lck integrates mitogenic NF-κB-dependent signals from the TCR and TRAIL in T lymphocytes...
  74. doi Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function
    Kole T Roybal
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Signal 3:pe24. 2010
    ..with that of other PKC family members? What are the functionally critical distinctions in the similar signaling systems of effector and regulatory T cells? Does the divergent localization of PKC-theta in regulatory T cells drive function?..
  75. doi NKG2D costimulates human V gamma 9V delta 2 T cell antitumor cytotoxicity through protein kinase C theta-dependent modulation of early TCR-induced calcium and transduction signals
    Steven Nedellec
    Institut National de la Sante et de la Recherche Medicale, U892, Centre de Recherche en Cancérologie Nantes Angers, Nantes, France
    J Immunol 185:55-63. 2010
    ..Therefore, this study identifies a new mechanism regulating Vgamma9Vdelta2 T cell functional plasticity through fine-tuning of early signal transduction events...
  76. ncbi Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells
    Shangwu Chen
    Immunology Group, Institute of Cell and Molecular Sciences, St Barts and The Royal London School of Medicine, Queen Mary University of London, London EC1A 7BE, UK
    Int Immunol 15:403-9. 2003
    ..These results suggest that CIS regulates PKC activation, and that this may be important for the activation of both the AP-1 and NF-kappaB pathways in TCR signaling...
  77. ncbi The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKCtheta and ERK pathways
    Gilles Despouy
    Institut Curie, Centre de Recherche, Paris, France
    Blood 110:4406-16. 2007
    ..Altogether, our data demonstrated that TCL1 inhibits AICD in T cells by blocking PKCtheta and ERK activation, upon cellular activation...
  78. ncbi [HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]
    Y Bennasser
    Laboratoire d Immuno Virologie, Université Paul Sabatier 118, route de Narbonne, 31062 Toulouse
    J Soc Biol 195:319-26. 2001
    ..Using microspectrofluorimetry and confocal microscopy, we also show that Tat induces a calcium influx...
  79. ncbi Regulation of retinoid X receptor responsive element-dependent transcription in T lymphocytes by Ser/Thr phosphatases: functional divergence of protein kinase C (PKC)theta; and PKC alpha in mediating calcineurin-induced transactivation
    Mohammad Ishaq
    Laboratory of Molecular Cell Biology, Science Applications International Corporation Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Immunol 169:732-8. 2002
    ..Thus, PKC theta; and PKC alpha may function as positive and negative modulators, respectively, of CN-regulated RXRE-dependent transcription during T cell activation...
  80. ncbi PKCtheta is required for the activation of human T lymphocytes induced by CD43 engagement
    Roxana del Rio
    Instituto de Biotecnología Universidad Nacional Autónoma de México, AP 510 3 Cuernavaca, MOR 62250, Mexico
    Biochem Biophys Res Commun 325:133-43. 2004
    ..Together, these data suggest that PKCtheta; plays a critical role in the co-stimulatory functions of CD43 in human T cells...
  81. ncbi Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence
    S F Pietromonaco
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Biol Chem 273:7594-603. 1998
    ..It appears likely that this activity corresponds to a specific intracellular pathway controlling the function of moesin as well as other ERM proteins...
  82. ncbi Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta
    James G Burchfield
    Cell Signalling Group, Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Biol Chem 279:18623-32. 2004
    ..Our data identify Ndrg2 as a novel insulin-dependent phosphoprotein and suggest that PKC may inhibit insulin action in part by reducing its phosphorylation by Akt...
  83. ncbi Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation
    Liansheng Sun
    Division of Hematology and Thromboembolic Diseases, Temple University School of Medicine, 3400 N Broad St, OMS 300, Philadelphia, PA 19140, USA
    Blood 103:948-54. 2004
    ....
  84. ncbi Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3
    Christine Teixeira
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Blood 102:1414-20. 2003
    ..A convergent DAG signaling system could be important in fine-tuning Ras signaling during B-cell development or during the humoral immune response...
  85. ncbi Comparative mapping of a region on chromosome 10 containing QTL for reproduction in swine
    D J Nonneman
    USDA, ARS, US Meat Animal Research Center, Spur 18D, Clay Center, NB, USA
    Anim Genet 34:42-6. 2003
    ..Six genes from human chromosome 10p (AKR1C2, PRKCQ, ITIH2, ATP5C1, PIP5K2A and GAD2) were mapped in the MARC swine mapping population...
  86. ncbi Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn
    D Ron
    Telik, Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19003-10. 1999
    ....
  87. ncbi Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens
    Barbara Cipriani
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Immunol 169:5761-70. 2002
    ..We conclude that the gammadelta T cell response to phosphoantigens is regulated by both novel and conventional PKC isoforms, with PKCtheta being more responsive to ligand stimulation and PKCalpha/beta to growth-factor availability...
  88. ncbi Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells
    P Borgatti
    Division of Signal Transduction, Harvard Institute of Medicine, Beth Israel Hospital, Boston, Massachusettes 02115, USA
    Biochem Biophys Res Commun 242:332-7. 1998
    ..Taken together, these findings demonstrate that extracellular Tat shows a cytokine-like activity in PC12 cells, being able to trigger an intracellular signalling cascade which involves PKC-alpha, -epsilon, and -zeta...
  89. ncbi Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures
    N Oshiro
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
    J Biol Chem 273:34663-6. 1998
    ..These results indicate that Rho-kinase regulates moesin phosphorylation downstream of Rho in vivo and that the phosphorylation of moesin by Rho-kinase plays a crucial role in the formation of microvilli-like structures...
  90. ncbi Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells
    S Tang
    Vascular Biology Unit and Cardiovascular Division, Department of Medicine, Beth Israel Hospital and the Harvard Thorndike Laboratories, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:28704-11. 1997
    ..Thus, PKCtheta is required for multiple processes essential for angiogenesis and wound repair, including endothelial mitosis, maintenance of a normal actin cytoskeleton, and formation of an enclosed tube...
  91. pmc Impaired activation of platelets lacking protein kinase C-theta isoform
    Bela Nagy
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 113:2557-67. 2009
    ..In conclusion, PKC-theta isoform plays a significant role in platelet functional responses downstream of PAR and GPVI receptors...
  92. pmc CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse
    Jianyong Huang
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:9369-73. 2002
    ....
  93. ncbi Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues
    J S Hayflick
    ICOS Corporation, Bothell, Washington 98021, USA
    J Biol Chem 272:22207-14. 1997
    ..This study delineates separable regions and amino acid residues within the cytoplasmic portion of ICAM-3 that are important for T cell function...
  94. ncbi Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells
    Santhakumar Manicassamy
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Mol Biol 355:347-59. 2006
    ..Thus, PKC-theta can both positively and negatively regulate the Ca2+ influx that is critical for NFAT activity...
  95. pmc Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL
    Allison M Beal
    Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Immunol 181:4815-24. 2008
    ..Thus, formation of a stable pSMAC, which is partially controlled by protein kinase Ctheta, functions to confine the released lytic molecules at the synaptic interface and to enhance the effectiveness of target cell lysis...
  96. ncbi The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28
    A Khoshnan
    Division of Clinical Immunology and Allergy, Department of Medicine, Center for Health Sciences, University of California, Los Angeles, CA 90095, USA
    J Immunol 165:6933-40. 2000
    ..Taken together, these data show that the activation of PKCtheta by the TCR and CD28 plays an important role in the assembly and activation of IKK complexes in the T cell membrane...
  97. ncbi Membrane raft association of CD47 is necessary for actin polymerization and protein kinase C theta translocation in its synergistic activation of T cells
    R A Rebres
    Center for Host Pathogen Interactions, University of California, San Francisco 94143, USA
    J Biol Chem 276:7672-80. 2001
    ..Full synergy with TCR requires CD47 localization to membrane rafts where ligation leads to TCR-independent signals causing actin polymerization and PKCtheta translocation...
  98. pmc PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis
    Karine Belguise
    Department of Biochemistry and Women s Health Interdisciplinary Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 117:4009-21. 2007
    ....
  99. ncbi Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting
    Dietlinde Wolf
    University of Miami, Miller School of Medicine, Department of Microbiology and Immunology, BCRI 739, Miami, FL 33136, USA
    Virology 370:45-54. 2008
    ..We conclude that the activation of nPKCs by Nef is required to increase viral replication/infectivity and direct the subcellular localization of Nef...
  100. ncbi The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway
    I H Chowdhury
    Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan
    Virology 176:126-32. 1990
    ....
  101. ncbi Theta-isoform of PKC is required for alterations in cytoskeletal dynamics and barrier permeability in intestinal epithelium: a novel function for PKC-theta
    A Banan
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 287:C218-34. 2004
    ..The ability to alter the cytoskeletal and barrier dynamics is a unique function not previously attributed to PKC-theta...

Research Grants67

  1. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 1992
    ..If so, it should set the stage for the thorough analysis of these important cytoskeletal elements...
  2. Genetic Predictors of Early Atherosclerosis in SLE
    Elizabeth Karlson; Fiscal Year: 2007
    ..abstract_text> ..
  3. Lipid-Protein Interactions in Viral Assembly and Virus Like Particle Formation
    ROBERT STAHELIN; Fiscal Year: 2009
    ....
  4. Lipid-Protein Interactions in Viral Assembly and Virus Like Particle Formation
    ROBERT VIRGIL STAHELIN; Fiscal Year: 2010
    ....
  5. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony P Bretscher; Fiscal Year: 2010
    ..Moreover, ezrin is elevated in many tumors, and an elevated level of ezrin has been shown to be necessary for metastasis in some tumor cell lines. ..
  6. Lipid-Protein Interactions in Viral Assembly and Virus Like Particle Formation
    ROBERT VIRGIL STAHELIN; Fiscal Year: 2010
    ....
  7. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  8. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2007
    ..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
  9. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  10. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 2005
    ..Since homologues of molecules critical for these processes in yeast have been associated with defects in mice and in human diseases, this work should be of general relevance. ..
  11. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2006
    ..This work should provide an integrated approach to the structure and function of the apical aspect of polarized cells. ..
  12. Clinical Risk Prediction Modeling in Rheumatoid Arthritis
    Elizabeth W Karlson; Fiscal Year: 2010
    ..This information will be used to develop personally tailored physical activity counseling to promote health and reduce cardiovascular risk of patients with RA. ..
  13. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2009
    ..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
  14. Clinical Risk Prediction Modeling in Rheumatoid Arthritis
    Elizabeth Karlson; Fiscal Year: 2009
    ..This information will be used to develop personally tailored physical activity counseling to promote health and reduce cardiovascular risk of patients with RA. ..
  15. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2009
    ..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
  16. Hormone, cytokine, and genetic risks for RA in women
    Elizabeth Karlson; Fiscal Year: 2007
    ..Ultimately, this study could lead to the identification of potential targets for therapeutic interventions to treat RA or to reduce the risk of this serious autoimmune disease. ..
  17. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2007
    ..Moreover, ezrin is elevated in many tumors, and an elevated level of ezrin has been shown to be necessary for metastasis in some tumor cell lines. ..
  18. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 1993
    ..The work set out in this study focusses on three proteins that play key roles in microfilament organizations. The results should provide some important basic information about the regulation and molecular organization of microfilaments...
  19. ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RA
    Elizabeth Karlson; Fiscal Year: 2002
    ..RA will be confirmed by a screening questionnaire regarding rheumatic symptoms and review of medical records. The study will identify potentially modifiable risk factors for primary prevention of RA. ..
  20. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2002
    ..g. EBP50) as well as different conformational states of ezrin. These studies will provide a comprehensive analysis of ezrin and EBP50 and the role they play in the structure and function of the apical membrane. ..
  21. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 2001
    ....
  22. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 1993
    ..These studies should greatly advance our goal of uncovering the function of actin and its associated proteins in yeast...