PRKCH

Summary

Gene Symbol: PRKCH
Description: protein kinase C eta
Alias: PKC-L, PKCL, PRKCL, nPKC-eta, protein kinase C eta type
Species: human

Top Publications

  1. ncbi The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes
    Miyoko Matsumura
    Institute of Molecular Oncology, Showa University, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 303:350-6. 2003
  2. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
  3. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
  4. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
  5. ncbi Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium
    M B Huang
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Acquir Immune Defic Syndr 25:375-89. 2000
  6. pmc Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart
    N Bacher
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 11:126-33. 1991
  7. ncbi The eta isoform of protein kinase C mediates transcriptional activation of the human transglutaminase 1 gene
    E Ueda
    Department of Dermatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Biol Chem 271:9790-4. 1996
  8. ncbi Phorbol 12-myristate 13-acetate induces protein kinase ceta-specific proliferative response in astrocytic tumor cells
    I M Hussaini
    Departments of Pathology Neuropathology, Biomedical Engineering, and Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:22348-54. 2000
  9. ncbi PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes
    M Kashiwagi
    Institute of Molecular Oncology, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Oncogene 19:6334-41. 2000
  10. ncbi PKCeta is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation: C1b domain and the pseudosubstrate containing fragment target PKCeta to the Golgi and the nuclear envelope
    Adva Maissel
    Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University, Beer Sheva 84105, Israel
    Cell Signal 18:1127-39. 2006

Research Grants

  1. Role of Ipc1 in fungal pathogenesis
    Maurizio Del Poeta; Fiscal Year: 2003
  2. FSHD Syndrome: DNA Repeats, Methylation, & Chromatin
    Melanie Ehrlich; Fiscal Year: 2003
  3. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
  4. FSHD: Chromatin Structure, Looping, & Expression
    Melanie Ehrlich; Fiscal Year: 2009

Patents

  1. NF-kB activating gene
  2. T cell activating gene

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes
    Miyoko Matsumura
    Institute of Molecular Oncology, Showa University, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 303:350-6. 2003
    ..These findings suggest that PKC eta negatively regulates UV-induced apoptosis through its localization, resistance to cleavage, and the p38 MAPK pathway...
  2. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
    ....
  3. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
    ....
  4. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
  5. ncbi Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium
    M B Huang
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Acquir Immune Defic Syndr 25:375-89. 2000
    ....
  6. pmc Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart
    N Bacher
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 11:126-33. 1991
    ..The ability of phorbol esters to bind to and stimulate the kinase activity of PKC-L was revealed by introducing the cDNA into COS cells...
  7. ncbi The eta isoform of protein kinase C mediates transcriptional activation of the human transglutaminase 1 gene
    E Ueda
    Department of Dermatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Biol Chem 271:9790-4. 1996
    ..In comparison with other PKC isoforms, nPKCeta most effectively induced the luciferase activity. We suggest that nPKCeta, an epithelium-specific isoform of PKC, mediates the activation of the TGase 1 transcription...
  8. ncbi Phorbol 12-myristate 13-acetate induces protein kinase ceta-specific proliferative response in astrocytic tumor cells
    I M Hussaini
    Departments of Pathology Neuropathology, Biomedical Engineering, and Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:22348-54. 2000
    ....
  9. ncbi PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes
    M Kashiwagi
    Institute of Molecular Oncology, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Oncogene 19:6334-41. 2000
    ..Among the known regulatory mechanisms of cdk2 activity, dephosphorylation of Thr160 was demonstrated. Oncogene (2000) 19, 6334 - 6341...
  10. ncbi PKCeta is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation: C1b domain and the pseudosubstrate containing fragment target PKCeta to the Golgi and the nuclear envelope
    Adva Maissel
    Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University, Beer Sheva 84105, Israel
    Cell Signal 18:1127-39. 2006
    ....
  11. ncbi Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population
    Yoichiro Takata
    The University of Tokushima, Tokushima, Japan
    Arthritis Rheum 56:30-42. 2007
    ..Analyses of families with rheumatoid arthritis (RA) have suggested the presence of a putative susceptibility locus on chromosome 14q21-23. This large population-based genetic association study was undertaken to examine this region...
  12. ncbi A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction
    Michiaki Kubo
    Department of Environmental Medicine, Kyushu University, Fukuoka 812 8582, Japan
    Nat Genet 39:212-7. 2007
    ..Here we report that a nonsynonymous SNP in a member of protein kinase C (PKC) family, PRKCH, was significantly associated with lacunar infarction in two independent Japanese samples (P = 5...
  13. ncbi PKCeta expression contributes to the resistance of Hodgkin's lymphoma cell lines to apoptosis
    Sara Abu-Ghanem
    Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
    Cancer Biol Ther 6:1375-80. 2007
    ..Thus, PKCeta could provide a new target aimed to reduce resistance to anti-cancer treatments of HL and other cancer patients...
  14. doi Association between PRKCH gene polymorphisms and subcortical silent brain infarction
    M Serizawa
    Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Atherosclerosis 199:340-5. 2008
    ..study has shown significant association of single nucleotide polymorphisms (SNPs) in the protein kinase C eta (PRKCH) gene with cerebral infarction, particularly, with lacunar infarction...
  15. doi The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population
    Lijun Wu
    First Affiliated Hospital, Medical College of Shantou University, Shantou, China
    Stroke 40:2973-6. 2009
    b>PRKCH (the gene encoding protein kinase C eta) has a role in the pathogenesis of ischemic stroke. The 1425G/A SNP in PRKCH (rs2230500) is significantly associated with ischemic stroke in Japanese...
  16. doi PKCeta confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells
    Noa Rotem-Dai
    The Schraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University, Beer Sheva, Israel
    Exp Cell Res 315:2616-23. 2009
    ..Thus, PKCeta could represent a target for intervention aimed to reduce resistance to anti-cancer treatments...
  17. doi PRKCH gene polymorphism is associated with the risk of severe gastric atrophy
    Yasuyuki Goto
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, 466 8550, Japan
    Gastric Cancer 13:90-4. 2010
    ..A G/A single nucleotide polymorphism (rs3783799) of the PRKCH gene, which encodes the eta isozyme of protein kinase C (PKCeta), has been reported to be a tag single nucleotide ..
  18. doi Protein kinase Cη activates NF-κB in response to camptothecin-induced DNA damage
    Hadas Raveh-Amit
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev, Israel
    Biochem Biophys Res Commun 412:313-7. 2011
    ..We and others have previously shown that PKCη confers protection against DNA damage-induced apoptosis. Our present study suggests that PKCη is involved in NF-κB signaling leading to drug resistance...
  19. ncbi Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase
    Danielle Libersan
    Montreal Heart Institute and the University of Montreal, Quebec, Canada
    Thromb Haemost 89:1016-23. 2003
    ..The novel epsilon and eta and atypical zeta, but not the conventional alpha and beta and the novel delta PKCs, may be involved in this process...
  20. ncbi Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms
    Toshio Shimada
    Department of Physiology, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    J Endocrinol 184:381-91. 2005
    ..Our findings suggest that PAF plays a role in the regulation of steroidogenesis via a mechanism mediated by the PAF receptor and PKC...
  21. pmc Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction
    Gary J Litherland
    Cell Signalling, Injury and Repair Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 285:22414-25. 2010
    ..Small interfering RNA-mediated silencing of PKC gene expression showed that both novel (nPKC delta, nPKC eta) and atypical (aPKC zeta, aPKC iota) isoforms were involved in collagenase induction by IL-1...
  22. ncbi The involvement of novel protein kinase C isozymes in influencing sensitivity of breast cancer MCF-7 cells to tumor necrosis factor-alpha
    A Basu
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Mol Pharmacol 53:105-11. 1998
    ..0 microM bryostatin 1 caused a 1.8-, 3.5- and 1.2-fold induction, respectively, of nPKC eta in MCF-7 cells. Similar exposure to BIM but not Gö 6976 led to a significant down-regulation of nPKC eta...
  23. ncbi Regulation of HIV-1 gag protein subcellular targeting by protein kinase C
    G Yu
    Laboratory of Biological Chemistry, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255
    J Biol Chem 270:4792-6. 1995
    ..This signal may provide a mechanism for the cellular regulation of virus development through modulation of gag protein-related developmental steps such as capsid targeting, assembly, encapsidation, budding, and maturation...
  24. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
  25. pmc Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway
    Xianjun Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 22:2099-110. 2002
    ..LPA and potentially other natural ligands primarily utilize a PKC-dependent pathway to modulate GSK-3...
  26. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
  27. ncbi The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3
    M De Donato
    Departamento de Biomedicina, IIBCA, Universidad de Oriente, Cumana, Venezuela
    Cytogenet Cell Genet 95:79-81. 2001
    ..3, 95.5% homology), and mouse Prkcl (MMU3, 13.8 cM, 87.6% homology) and rat Prkcl (88.8% homology)...
  28. ncbi The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway
    R M Uht
    Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 26:2885-93. 2007
    ..Elk-1 target genes involved in GBM proliferative responses have yet to be identified...
  29. pmc ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation
    Melanie Ehrlich
    Hayward Human Genetics Program, Tulane Medical School, New Orleans, LA 70112, USA
    Autoimmunity 41:253-71. 2008
    ..BCL2L10, CASP1, and PTPN13); nitrous oxide, carbon monoxide, NF-kappaB, and TNFalpha signalling pathway genes (PRKCH, GUCY1A3, GUCY1B3, MAPK13; HMOX1, and MAP4K4); and transcription control genes (NR2F2 and SMARCA2)...
  30. doi PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway
    Akihisa Oda
    Division of Molecular Biology, Tokyo University of Science, Noda, Chiba 278 0022, Japan
    Int Immunol 20:1417-26. 2008
    ..These results indicate that PKC eta directs the induction of IRF-4 expression downstream of BLNK in the pre-BCR signaling pathway promoting kappa gene rearrangement...
  31. doi Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway
    Ramesh P Thylur
    Department of Life Science, Cell Dynamics Research Center, BioImaging Research Center, and Research Center for Biomolecular Nanotechnology, GIST, Gwangju 500 712, South Korea
    J Cell Biochem 108:705-15. 2009
    ..Collectively, these results suggest that swiprosin-1 is a PKC-beta I/eta-inducible gene and it modulates mast cell activation through NF-kappaB-dependent pathway...
  32. pmc Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance
    Suryakant K Niture
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cell Sci 122:4452-64. 2009
    ....
  33. doi Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
    Jürgen van Baal
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Int J Biochem Cell Biol 44:1791-9. 2012
    ..Our data indicate that DGKθ translocation and activity is regulated by the concerted activity of EGFR and PKC and that DGKθ attenuates PKC-mediated Thr654 phosphorylation that is linked to desensitisation of EGFR signaling...
  34. doi Impact of the 1425G/A polymorphism of PRKCH on the recurrence of ischemic stroke: Fukuoka Stroke Registry
    Ryu Matsuo
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka Electronic address
    J Stroke Cerebrovasc Dis 23:1356-61. 2014
    ..single-nucleotide polymorphism (rs2230500 single-nucleotide polymorphism) in exon 9 of the protein kinase C eta (PRKCH) gene is an independent risk factor for ischemic stroke: stroke incidence is significantly higher in the subjects ..
  35. doi Silencing of PKCη induces cycle arrest of EBV(+) B lymphoma cells by upregulating expression of p38-MAPK/TAp73/GADD45α and increases susceptibility to chemotherapeutic agents
    Ga Bin Park
    Department of Anatomy and Research Center for Tumor Immunology, Inje University College of Medicine, Busan 614 735, Republic of Korea
    Cancer Lett 350:5-14. 2014
    ..These results suggest that siRNA-mediated silencing of PKCη can be a potent tool to complement existing chemotherapy regimens for treating EBV(+) B lymphoma. ..
  36. pmc NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells
    Nurdan Ozkucur
    Department of Anatomy, Medical Theoretical Center, Technische Universitat Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    Cell Mol Life Sci 71:4653-63. 2014
    ..Taken together, these data suggest that PKCη-dependent phosphorylation of NHE3 and the formation of pNHE3/PKCη/ɣ-tubulin complexes at the leading edge of the cell are required for directional cell migration in an EF...
  37. pmc Discovery of a dicer-independent, cell-type dependent alternate targeting sequence generator: implications in gene silencing & pooled RNAi screens
    Bhavneet Bhinder
    HTS Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 9:e100676. 2014
    ..We synthesized and tested all of them. Surprisingly, six duplexes targeting ASH1L, DROSHA, GNG7, PRKCH, THEM4, and WDR92 scored as active...
  38. doi A quantitative assessment of the association between 1425G/A polymorphism in PRKCH and risk of stroke
    Lingli Sun
    Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China
    Neuromolecular Med 16:814-20. 2014
    Previous studies suggested an association between 1425G/A polymorphism in PRKCH and stroke risk, but the results were inconsistent...
  39. doi Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population
    Yi Chun Chen
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    Biomed J 38:433-8. 2015
    Prior studies suggested that protein kinase Cη (PRKCH) 1425G/A polymorphism was associated with lacunar infarction. This study examined whether the association was independent of traditional risk factors in each of the stroke subtypes.
  40. doi G-protein genomic association with normal variation in gray matter density
    Jiayu Chen
    The MIND Research Network, Albuquerque, New Mexico
    Hum Brain Mapp 36:4272-86. 2015
    ..synaptic plasticity, axon guidance, molecular signal transduction via PKA and CREB, highlighting the GRM1, PRKCH, GNA12, and CAMK2B genes...
  41. ncbi Characterization of a protein kinase C gene in Sporothrix schenckii and its expression during the yeast-to-mycelium transition
    E Aquino-Piñero
    Department of Microbiology and Medical Zoology, University of Puerto Rico, San Juan 00936 5067, USA
    Med Mycol 40:185-99. 2002
    ..In this study, we identified the presence of two pkcl-like genes in S. schenckii...
  42. ncbi Association of CPI-17 with protein kinase C and casein kinase I
    Eva Zemlickova
    University of Edinburgh, Division of Biomedical and Clinical Laboratory Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Biochem Biophys Res Commun 316:39-47. 2004
    ..We previously found that CPI-17 co-purified with casein kinase I in brain suggesting they are part of a complex and we now show that CPI-17 associates with the kinase domain of CKI isoforms...
  43. pmc miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway
    Ming xue Zhang
    Department of Ophthalmology, The Second Hospital of Tianjin Medical University, Tianjin, China
    PLoS ONE 11:e0158433. 2016
    ..miR-24-3p down-regulated protein kinase C eta (PRKCH) by binding to its untranslated region (3'UTR)...
  44. pmc Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C
    A Jakobovits
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 9:1165-70. 1990
    ..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth...
  45. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
  46. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996
    ..Several Tat peptides, containing serine at position 46, are the only ones which are phosphorylated at significant rates. Several other Tat peptides containing potential protein kinase C phosphorylation sites are not phosphorylated...
  47. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
    ..Recombinant p21-activated kinase hPAK65, a recently proposed relative of the Nef-associated kinase, achieved a comparable result. Taken together, these data suggest that MA is a target of the Nef-associated serine kinase...
  48. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
    ..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
  49. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  50. ncbi Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon)
    Ilona Brändlin
    Fraunhofer Institute for Interfacial Engineering, Nobelstrabetae 12, 70569 Stuttgart, Germany
    J Biol Chem 277:45451-7. 2002
    ..In this study, we show that differentially activated kinase cascades involving PDK1 and novel PKC isotypes are responsible for the regulation of PKC(mu) activity and consequently inhibit the JNK pathway...
  51. ncbi Neurotrophic effect of Semaphorin 4D in PC12 cells
    Shiho Fujioka
    Group of Neurobiology, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Yamadaoka 1 7, Suita Shi, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 301:304-10. 2003
    ..These findings suggest a new function of Sema4D as a neurotrophic signal in PC12 cells...
  52. ncbi Enhancement of apparent substrate selectivity of proteinase K encapsulated in liposomes through a cholate-induced alteration of the bilayer permeability
    Makoto Yoshimoto
    Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Yamaguchi University, 2 16 1 Tokiwadai, Ube, 755 8611 Japan
    Biotechnol Bioeng 85:222-33. 2004
    ..Proteinase K-containing mixed liposomes (PKCL) were prepared by adding cholate to preformed proteinase K-containing POPC liposomes (PKL) at a defined effective ..
  53. ncbi Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting
    Dietlinde Wolf
    University of Miami, Miller School of Medicine, Department of Microbiology and Immunology, BCRI 739, Miami, FL 33136, USA
    Virology 370:45-54. 2008
    ..We conclude that the activation of nPKCs by Nef is required to increase viral replication/infectivity and direct the subcellular localization of Nef...
  54. doi c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Rm 4NN16, 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Mol Cell Biochem 330:23-9. 2009
    ..Collectively, these findings further corroborate the concept that gp120 plays an important role, via involvement of molecules such as c-FLIPL, in apoptotic cell death due to HIV-1 infection...
  55. doi Type V collagen and protein kinase C η down-regulation in 8701-BC breast cancer cells
    Claudio Luparello
    Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, STEMBIO, Universita di Palermo, Palermo, Italy
    Mol Carcinog 52:348-58. 2013
    ....
  56. doi PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation
    Galit Shahaf
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Science and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Exp Cell Res 318:789-99. 2012
    ....
  57. doi Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
    Yukinori Okada
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:511-6. 2012
    ..This provided evidence of shared genetic risks of rheumatoid arthritis between the populations...
  58. doi Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia
    Le Huang
    Department of Biomedical Science, Medicine, Nursing and Health Sciences Faculty, Monash University Clayton Campus, Melbourne, Australia
    Hematology 17:71-5. 2012
    ..Deficiency of these gene expression levels might represent the feature related to T-cell immunodeficiency. The study might contribute to better understand the cellular immune features in CLL patients...
  59. doi Protein kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the Taiwan population
    Yi Chun Chen
    Department of Neurology, Chang Gung Memorial Hospital, LinKou Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Neurosci Lett 528:170-3. 2012
    Protein kinase Cη (PRKCH) 1425G/A polymorphism has been suggested to be a susceptible genetic locus of stroke by genome-wide polymorphism analysis with several replication reports in the Asian populations...
  60. pmc Upregulation of PKCη by PKCε and PDK1 involves two distinct mechanisms and promotes breast cancer cell survival
    Deepanwita Pal
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochim Biophys Acta 1830:4040-5. 2013
    ..We recently showed that these activators induced selective upregulation of PKCη in breast cancer cells. The objective of this study is to understand unique regulation of PKCη and its importance in breast cancer...
  61. pmc Competing molecular interactions of aPKC isoforms regulate neuronal polarity
    Sara S Parker
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 110:14450-5. 2013
    ..Prkcz encodes aPKC-ζ and PKM-ζ, a truncated, neuron-specific alternative transcript, and Prkcl encodes aPKC-λ...
  62. pmc Protein kinase C group B members PKC-delta, -epsilon, -zeta and PKC-L(eta). Comparison of properties of recombinant proteins in vitro and in vivo
    M Liyanage
    Max Delbrück Laboratorium, Max Planck Gesellschaft, Koln, Germany
    Biochem J 283:781-7. 1992
    ..Consistent with their ability to bind phorbol ester, recombinant PKC-delta and PKC-epsilon are down-regulated in COS cells by prolonged treatment with phorbol ester, whereas PKC-zeta protein levels remain unaltered...
  63. ncbi The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway
    I H Chowdhury
    Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan
    Virology 176:126-32. 1990
    ....
  64. ncbi A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin
    S Osada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    J Biol Chem 265:22434-40. 1990
    Protein kinase C (PKC)-related cDNA clones isolated from mouse epidermis cDNA library encoded a 78-kDa protein, nPKC eta. nPKC eta contains a characteristic cysteine-rich repeat sequence (C1 region) and a protein kinase domain sequence (..
  65. ncbi Human immunodeficiency virus induces phosphorylation of its cell surface receptor
    A P Fields
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231
    Nature 333:278-80. 1988
    ..These results indicate a possible role for HIV-induced CD4 phosphorylation in viral entry and identify a potential target for antiviral therapy...
  66. ncbi HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells
    N Chirmule
    Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030, USA
    J Biol Chem 270:19364-9. 1995
    ..g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion...
  67. ncbi Identification of multiple, novel, protein kinase C-related gene products
    R H Palmer
    Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, London, UK
    FEBS Lett 356:5-8. 1994
    ..The origin and relationships of these predicted proteins is discussed...
  68. ncbi Expression in lung tumors and genetic mapping of the novel murine protein kinase C eta
    F Canzian
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Mol Carcinog 9:111-3. 1994
    Protein kinase C eta (nPKC eta) is a member of the protein kinase C family with a unique tissue distribution in skin and lung...
  69. ncbi Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta
    M F Denning
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    J Biol Chem 271:5325-31. 1996
    ....
  70. ncbi Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells
    P Borgatti
    Division of Signal Transduction, Harvard Institute of Medicine, Beth Israel Hospital, Boston, Massachusettes 02115, USA
    Biochem Biophys Res Commun 242:332-7. 1998
    ..Taken together, these findings demonstrate that extracellular Tat shows a cytokine-like activity in PC12 cells, being able to trigger an intracellular signalling cascade which involves PKC-alpha, -epsilon, and -zeta...
  71. ncbi Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways
    R Zidovetzki
    Department of Biology and Neuroscience, University of California, Riverside 92521, USA
    AIDS Res Hum Retroviruses 14:825-33. 1998
    ..Both the Tat-induced increase in intracellular cAMP and IL-6 mRNA levels in CNS-ECs may play a role in altering the blood-brain barrier and thereby inducing pathology often observed in AIDS dementia...
  72. ncbi Effects of PKC and PKA phosphorylation on desensitization of nicotinic acetylcholine receptors
    T Nishizaki
    Department of Physiology, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Brain Res 812:242-5. 1998
    ..The selective PKC inhibitor, PKCl, prolonged the rate of desensitization of normal ACh receptors, and the similar effect was obtained with mutant ACh ..
  73. ncbi Cloning and characterization of the human protein kinase C-eta promoter
    T Quan
    Department of Dermatology, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:28566-74. 1999
    ..Mutations of the Ets/heat shock factor binding sites caused loss of functional enhancer activity. These data elucidate transcriptional regulation and tissue-specific expression of the PKC-eta gene...
  74. pmc HIV envelope gp120 activates human arterial smooth muscle cells
    A D Schecter
    Zena and Michael A Wiener Cardiovascular Institute and Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 98:10142-7. 2001
    ..The activation of smooth muscle cells by gp120 may play an important role in the vascular, thrombotic, and inflammatory responses to HIV infection...
  75. ncbi Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes
    Susanna Fagerholm
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 277:1728-38. 2002
    ..Thus, PKC-mediated phosphorylation of CD18 after cell stimulation could lead to the recruitment of 14-3-3 proteins to the activated integrin, which may play a role in regulating its adhesive state or ability to signal...
  76. ncbi Altered expression and localization of PKC eta in human breast tumors
    P A Masso-Welch
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 68:211-23. 2001
    ..The invasive tumors which possessed high PKC eta staining were associated with positive lymph node status. These results demonstrate that quantitative and qualitative alterations in PKC eta occur in human breast cancers...
  77. pmc Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation
    Isa M Hussaini
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    Neuro Oncol 4:9-21. 2002
    ..The data demonstrate that resistance to UV and gamma irradiation in glioblastoma cell lines is modified significantly by PKC-eta expression and that PKC-eta appears to block the apoptotic cascade at caspase-9 activation...
  78. ncbi [HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]
    Y Bennasser
    Laboratoire d Immuno Virologie, Université Paul Sabatier 118, route de Narbonne, 31062 Toulouse
    J Soc Biol 195:319-26. 2001
    ..Using microspectrofluorimetry and confocal microscopy, we also show that Tat induces a calcium influx...
  79. pmc Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice
    Sylvie Lachmann
    Applied Tumour Virology Program, Department F010 and Institut National de la Santé et de la Recherche Médicale U375, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Virol 77:8048-60. 2003
    ..Altogether, our results underline the tight interconnection between PKC-mediated signaling and the parvoviral life cycle...
  80. ncbi Protein kinase C eta is associated with progression of renal cell carcinoma (RCC)
    Walburgis Brenner
    Department of Urology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Anticancer Res 23:4001-6. 2003
    ..The expression of all eleven PKC-isoforms in clear cell RCCs (ccRCC) and in the corresponding normal renal tissue was quantified. A possible association of PKC-isoforms with histopathological parameters was examined...
  81. ncbi AKAP-Lbc nucleates a protein kinase D activation scaffold
    Graeme K Carnegie
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Mol Cell 15:889-99. 2004
    ..This configuration illustrates the utility of kinase anchoring as a mechanism to constrain the action of broad-spectrum enzymes...
  82. ncbi PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways
    Sean E Aeder
    Department of Pathology and Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 23:9062-9. 2004
    ..However, activation of Akt, but not mTOR was inhibited by the PI-3 kinase inhibitor LY294002. This study identifies Akt and mTOR as downstream targets of PKC-eta that are involved in GBM cell proliferation...
  83. ncbi Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C
    Jürgen van Baal
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands
    J Biol Chem 280:9870-8. 2005
    ..Our data are consistent with the concept that hormone-induced PKC activation regulates the intracellular localization of DGK, which may be important in the negative regulation of PKCepsilon and/or PKCeta activity...
  84. ncbi The Par6alpha/aPKC complex regulates Akt1 activity by phosphorylating Thr34 in the PH-domain
    P Weyrich
    Department of Internal Medicine IV, University of Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Mol Cell Endocrinol 268:30-6. 2007
    ..In summary, Par6alpha-mediated inhibition of insulin-dependent glycogen synthesis in C2C12 cells depends on the direct interaction of Par6alpha with aPKC and on aPKC-mediated T34 phosphorylation of Akt1...
  85. ncbi Association and expression study of PRKCH gene in a French Caucasian population with rheumatoid arthritis
    Vitor Hugo Teixeira
    GenHotel EA3886, Evry Paris VII Universities, Evry Genopole, France
    J Clin Immunol 28:115-21. 2008
    ..Furthermore, the lower expression of this gene in rheumatoid arthritis patients comparing to healthy controls suggests that protein kinase C, eta could be associated with the patho-physiologic mechanism of rheumatoid arthritis...
  86. pmc Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response
    M L Wong
    Department of Psychiatry and Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Psychiatry 13:800-12. 2008
    ..We found associations of several SNPs and antidepressant response; those genes support the role of T cell (CD3E, PRKCH, PSMD9 and STAT3) and hypothalamic-pituitary-adrenal axis (UCN3) functions in treatment response...
  87. pmc PKC eta regulates occludin phosphorylation and epithelial tight junction integrity
    Takuya Suzuki
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Proc Natl Acad Sci U S A 106:61-6. 2009
    ..These results reveal an important mechanism of epithelial TJ regulation by PKC eta...
  88. ncbi [Molecular epidemiology of cerebrovascular diseases; the Hisayama study and the Fukuoka Stroke Registry (FSR)]
    Takanari Kitazono
    Department of Nephrology, Hypertension, and Strokology, Kyushu University Hospital
    Rinsho Shinkeigaku 48:892-5. 2008
    ..We performed a genome-wide case-control study and found that a nonsynonymous SNP in PRKCH encoding a member of protein kinase C (PKCC eta) was significantly associated with brain infarction...
  89. pmc Activation of protein kinase C{eta} by type I interferons
    Amanda J Redig
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 284:10301-14. 2009
    ..Altogether, our studies establish PKCeta as a unique element in IFN signaling that plays a key and essential role in the generation of the regulatory effects of type I IFNs on normal and leukemic hematopoiesis...
  90. ncbi Metallothioneins and cancer
    Tomas Eckschlager
    Department of Chemistry and Biochemistry, Mendel University of Agriculture and Forestry, Zemedelska 1, Brno CZ 613 00, Czech Republic
    Curr Protein Pept Sci 10:360-75. 2009
    ..MTs are also involved with several important proteins e.g. p53, NF-kappaB, PKCl, and GTPase Rab3A...
  91. doi Analysing the expression of protein kinase C eta in human hepatocellular carcinoma
    Hsiu Chin Lu
    Departments of Laboratory Medicine and Clinical Research, Kaohsiung Medical University Hospital, Institute of Clinical Research, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Pathology 41:626-9. 2009
    ..In this report, we investigated the expression of PKCeta in human hepatocellular carcinoma (HCC) tissues and explored its role in the development of HCC...
  92. doi Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes
    Nagisa Kamioka
    Institute of Molecular Oncology, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 394:106-11. 2010
    ..These findings suggest that inverse effects of PKCdelta and PKCeta on loricrin expression attributes to the expression of c-Jun and JunD...
  93. doi Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells
    Therese Solstad
    The Biotechnology Centre of Oslo University of Oslo, Oslo, Norway
    Proteomics 10:2758-68. 2010
    ..Our results demonstrate that in-depth proteomic analysis of DRMs provides a tool to study differential localization and regulation of signaling molecules important in health and disease...
  94. doi MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits
    J E Lee
    Center for Genome Science, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, South Korea
    Cell Prolif 44:59-66. 2011
    ..The aim of this study was to identify miRNAs associated with terminal immortalization of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell line (LCL) and associated clinical traits...
  95. pmc Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation
    Yasuhito Shirai
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Mol Biol Cell 22:1340-52. 2011
    ..These results provide a new insight into the molecular mechanism of cytoskeletal regulation leading to drastic change of cell shape...
  96. ncbi [Genome-wide association study for ischemic stroke based on the Hisayama study]
    Jun Hata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nihon Eiseigaku Zasshi 66:47-52. 2011
    ..among the residents of the town of Hisayama, Japan, we identified three novel candidate genes for ischemic stroke: PRKCH (protein kinase C eta (PKCη)), AGTRL1 (apelin receptor), and ARHGEF10 (Rho guanine nucleotide exchange factor 10)...
  97. ncbi Association of the genetic variants of APOA5 and PRKCH with hypertension in community-dwelling Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Mol Med Rep 1:407-14. 2008
    ..3'-UTR) polymorphism of CRP, the -1131T↷C polymorphism of APOA5 and the 1425G↷A (Val374Ile) polymorphism of PRKCH using melting curve analysis...
  98. pmc Identification of homogeneous genetic architecture of multiple genetically correlated traits by block clustering of genome-wide associations
    Mayetri Gupta
    Department of Biostatistics, Boston University, Boston, MA, USA
    J Bone Miner Res 26:1261-71. 2011
    ..In addition to several known candidate genes, we also identified PRKCH and SCNN1B as potential candidate genes for multiple bone traits...
  99. doi The role of PRKCH gene variants in coronary artery disease in a Chinese population
    Jun Zhu
    Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu Province, China
    Mol Biol Rep 39:1777-82. 2012
    The aim of the present study was to assess the influences of PRKCH gene variants (1425G/A and _15) on the risk of coronary artery disease (CAD) in a Chinese population...
  100. doi Contribution of 1425G/A polymorphism in protein kinase C-Eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu City, Aichi Prefecture, Japan
    J Neurogenet 25:82-7. 2011
    Protein kinase C-eta (PRKCH) gene has been recently identified as a susceptible risk locus for cerebral infarction and hemorrhage in the Asian populations...
  101. doi Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: a meta-analysis including 3686 cases and 4589 controls
    Jiaoxing Li
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    Neurosci Lett 506:55-8. 2012
    Meta-analysis was performed to investigate the association between 1425G/A SNP in PRKCH (the gene encoding for protein kinase C η) and ischemic stroke among Chinese and Japanese populations.

Research Grants5

  1. Role of Ipc1 in fungal pathogenesis
    Maurizio Del Poeta; Fiscal Year: 2003
    ..Ipc 1 regulates melanin production through the modulation of DAG and the consequent activation of protein kinase C (Pkcl). Based on these observations, we hypothesize that Ipc 1 is a key regulator of pathogenicity of C...
  2. FSHD Syndrome: DNA Repeats, Methylation, & Chromatin
    Melanie Ehrlich; Fiscal Year: 2003
    ..The proposed research should help elucidate the molecular etiology of the enigmatic FSHD syndrome. ..
  3. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
    ..Understanding the role of LRP in the migration and invasion astrocytic tumors will provide information on possible specific targets for therapeutic intervention. [unreadable] [unreadable]..
  4. FSHD: Chromatin Structure, Looping, & Expression
    Melanie Ehrlich; Fiscal Year: 2009
    ..The proposed research should elucidate new aspects of long-distance control of gene expression as well as lending clinically useful insights into this currently intractable disease. ..

Patents2

  1. NF-kB activating gene
    Patent Number: WO03048202-A2; Date:2003-06-12
  2. T cell activating gene
    Patent Number: WO2004058805-A2; Date:2004-07-15